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https://www.readbyqxmd.com/read/28437506/treatment-of-unstable-trochanteric-femur-fractures-proximal-femur-nail-versus-proximal-femur-locking-compression-plate
#1
Ashutosh Kumar Singh, Nidi Narsaria, Arun G R, Vivek Srivastava
Unstable trochanteric femur fractures are common fractures that are difficult to manage. We conducted a prospective study to compare functional outcomes and complications of 2 different implant designs, proximal femur nail (PFN) and proximal femur locking compression plate (PFLCP), used in internal fixation of unstable trochanteric femur fractures. On hospital admission, 48 patients with unstable trochanteric fractures were randomly assigned (using a sealed envelope method) to treatment with either PFN (24 patients) or PFLCP (24 patients)...
March 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28437479/conformational-dynamics-of-bacterial-trigger-factor-in-apo-and-ribosome-bound-states
#2
Mehmet Tarik Can, Zeynep Kurkcuoglu, Gokce Ezeroglu, Arzu Uyar, Ozge Kurkcuoglu, Pemra Doruker
The chaperone trigger factor (TF) binds to the ribosome exit tunnel and helps cotranslational folding of nascent chains (NC) in bacterial cells and chloroplasts. In this study, we aim to investigate the functional dynamics of fully-atomistic apo TF and its complex with 50S. As TF accomodates a high percentage of charged residues on its surface, the effect of ionic strength on TF dynamics is assessed here by performing five independent molecular dynamics (MD) simulations (total of 1.3 micro-second duration) at 29 mM and 150 mM ionic strengths...
2017: PloS One
https://www.readbyqxmd.com/read/28437062/molecular-arrangement-and-charge-transfer-in-c60-graphene-heterostructures
#3
Claudia Ojeda-Aristizabal, Elton J G Santos, Seita Onishi, Aiming Yan, Haider Imad Rasool, Salman Kahn, Yinchuan Lv, Drew Latzke, Jairo Velasco, Michael F Crommie, Matthew Sorensen, Kenneth Gotlieb, Chiu-Yun Lin, Kenji Watanabe, Takashi Taniguchi, Alessandra Lanzara, Alex Zettl
Charge transfer at the interface between dissimilar materials is at the heart of electronics and photovoltaics. Here we study the molecular orientation, electronic structure, and local charge transfer at the interface region of C60 deposited on graphene, with and without supporting substrates such as hexagonal boron nitride. We employ ab initio density functional theory with van der Waals (vdW) interactions, and experimentally characterize interface devices using high-resolution transmission electron microscopy and electronic transport...
April 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28436597/glycan-analysis-by-ion-mobility-mass-spectrometry
#4
Johanna Hofmann, Kevin Pagel
Carbohydrates form one of the major classes of biological macromolecules in living organisms. To investigate their properties and function, an in-depth knowledge of their underlying structure is essential. However, the inherent structural complexity of glycans represents a major challenge. Carbohydrates are often branched and exhibit diverse regio- and stereochemistry. This in turn leads to a vast number of possible isomers, which are difficult to distinguish using established analytical tools. In the last decade, ion mobility-mass spectrometry, a technique that separates ions based on their mass, charge, size and shape, emerged as a powerful alternative for isomer distinction...
April 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28436500/black-phosphorus-nanostructures-recent-advances-in-hybridization-doping-and-functionalization
#5
Wanying Lei, Gang Liu, Jin Zhang, Minghua Liu
Owing to its high charge-carrier mobility, tunable direct-bandgap and unique in-plane anisotropic structure, black phosphorus (BP), a rising star of post-graphene two-dimensional (2D) nanomaterials, has been intensively investigated since early 2014. To explore its full potential and push the limits, research into BP-based novel functional nanostructures (i.e., nanomaterials and nanodevices) by means of hybridization, doping, and functionalization is rapidly expanding. Indeed, the cutting-edge developments and applications of BP nanostructures have had a significant impact on a wide range of research areas, including field effect transistors, diodes, photodetectors, biomedicine, sodium-ion batteries, photocatalysis, electrocatalysis, memory devices, and more...
April 24, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28436155/the-mobius-airo-mobile-ct-for-image-guided-proton-therapy-characterization-commissioning
#6
Jasmine A Oliver, Omar A Zeidan, Sanford L Meeks, Amish P Shah, Jason Pukala, Patrick Kelly, Naren R Ramakrishna, Twyla R Willoughby
PURPOSE: The purpose of this study was to characterize the Mobius AIRO Mobile CT System for localization and image-guided proton therapy. This is the first known application of the AIRO for proton therapy. METHODS: Five CT images of a Catphan(®) 504 phantom were acquired on the AIRO Mobile CT System, Varian EDGE radiosurgery system cone beam CT (CBCT), Philips Brilliance Big Bore 16 slice CT simulator, and Siemens SOMATOM Definition AS 20 slice CT simulator. DoseLAB software v...
April 24, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28435985/elucidating-the-a%C3%AE-42-anti-aggregation-mechanism-of-action-of-tramiprosate-in-alzheimer-s-disease-integrating-molecular-analytical-methods-pharmacokinetic-and-clinical-data
#7
Petr Kocis, Martin Tolar, Jeremy Yu, William Sinko, Soumya Ray, Kaj Blennow, Howard Fillit, John A Hey
BACKGROUND: Amyloid beta (Aβ) oligomers play a critical role in the pathogenesis of Alzheimer's disease (AD) and represent a promising target for drug development. Tramiprosate is a small-molecule Aβ anti-aggregation agent that was evaluated in phase III clinical trials for AD but did not meet the primary efficacy endpoints; however, a pre-specified subgroup analysis revealed robust, sustained, and clinically meaningful cognitive and functional effects in patients with AD homozygous for the ε4 allele of apolipoprotein E4 (APOE4/4 homozygotes), who carry an increased risk for the disease...
April 24, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28435968/unexpected-proton-mobility-in-the-bulk-phase-of-cholinium-based-ionic-liquids-new-insights-from-theoretical-calculations
#8
Marco Campetella, Maria Montagna, Lorenzo Gontrani, Eleonora Scarpellini, Enrico Bodo
We have explored by means of ab initio molecular dynamics two ionic liquids based on the combination of a choline cation with deprotonated cysteine and aspartic acid anions. While the combination of the strong base choline with various other amino-acids leads to the formation of a highly ionized medium where proton transfer is negligible, the presence of additional protic functions on the SH and COOH groups leads to an unexpected and interesting behavior and to a sizable migration of their acidic protons onto the NH2 basic terminals...
April 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28435916/feasibility-of-endoscopic-discectomy-by-inter-laminar-approach-at-a-high-volume-tertiary-public-hospital-in-a-developing-country
#9
Shardul Madhav Soman, Jayprakash Vrajlal Modi, Jimmy Chokshi
BACKGROUND: Surgical treatment for lumbar disc herniation consists of discectomy performed either open or minimally invasive techniques. Endoscopic discectomy using the tubular retractor is been increasingly used as it gives advantage of smaller incision, less tissue injury and faster recovery. The aim of this study was to check its feasibility and learning curve at a tertiary public sector hospital with a large volume load (more than 50 spine surgeries per month) with treatment provided free of cost...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28435562/avulsion-fracture-of-brachioradialis-muscle-origin-an-exceedingly-rare-entity-a-case-report
#10
G Behera, G Balaji, J Menon, D Sharma, V K Komuravalli
Avulsion fracture of the brachioradialis origin at its proximal attachment on the lateral supracondylar ridge of the distal humerus is exceedingly rare, and only two cases have been reported in the literature so far. In this article, we present a 38 years old patient who sustained a closed avulsion fracture of the lateral supracondylar ridge of left humerus at the proximal attachment of brachioradialis following a fall backwards on outstretched hand after being struck by a lorry from behind while riding on a two-wheeler (motorcycle)...
July 2016: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/28435321/a-behavioral-medicine-intervention-for-community-dwelling-older-adults-with-chronic-musculoskeletal-pain-protocol-for-a-randomized-controlled-trial
#11
Sara Cederbom, Eva Denison, Astrid Bergland
BACKGROUND: Chronic musculoskeletal pain is a major health problem among older adults, particularly those who live alone and/or those who are dependent on formal care. Chronic pain is associated with mobility problems, falls, fear of falling, catastrophizing thoughts, and a lower quality of life. Research shows that physical therapy interventions based on behavioral medicine approaches are beneficial for middle-aged adults with chronic pain. However, there appears to be no previous randomized controlled trials (RCTs) based on this theoretical framework that have examined the effect on older adults with chronic musculoskeletal pain who live alone at home and are dependent on formal care to manage their everyday lives...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28435282/managing-the-patient-with-osteogenesis-imperfecta-a-multidisciplinary-approach
#12
REVIEW
Caroline Marr, Alison Seasman, Nick Bishop
Osteogenesis imperfecta (OI) is a heterogeneous heritable connective tissue disorder characterized by low bone density. The type and severity of OI are variable. The primary manifestations are fractures, bone deformity, and bone pain, resulting in reduced mobility and function to complete everyday tasks. OI affects not only the physical but also the social and emotional well-being of children, young people, and their families. As such, medical, surgical, and allied health professionals' assessments all play a role in the management of these children...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28435270/relationship-between-hypnosis-and-personality-trait-in-participants-with-high-or-low-hypnotic-susceptibility
#13
Yingchun Zhang, Yunke Wang, Chanchan Shen, Yingying Ye, Si Shen, Bingren Zhang, Jiawei Wang, Wei Chen, Wei Wang
BACKGROUND: The relationship between normal personality and hypnotic susceptibility is important for understanding mental processing and mental disorders, but it is less consistent in normal people or in patients with a psychiatric disorder. We have hypothesized that the correlation exists but varies in individuals with different levels of hypnotizability. PARTICIPANTS AND METHODS: We invited 72 individuals with high (HIGH group) and 47 individuals with low (LOW group) hypnotic susceptibilities to undertake tests of NEO-PI-R and the Stanford Hypnotic Susceptibility Scale, Form C (SHSSC)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28435219/clinical-effectiveness-of-currently-available-low-vision-devices-in-glaucoma-patients-with-moderate-to-severe-vision-loss
#14
Yogesh Patodia, Elizabeth Golesic, Alex Mao, Cindy Ml Hutnik
PURPOSE: The aim of this trial is to study the effectiveness of currently available low-vision devices in glaucoma patients with moderate-to-severe vision loss. DESIGN: This is a randomized pilot clinical trial. PARTICIPANTS: Sixteen low-vision glaucoma patients participated in this study. METHODS: Patients with a best-corrected visual acuity between 20/70 and 20/400 in the better eye and a diagnosis of stable primary or secondary open-angle glaucoma were randomized to a low-vision treatment group or a nonintervention control group...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28435105/organ-specific-proteomics-of-soybean-seedlings-under-flooding-and-drought-stresses
#15
Xin Wang, Ehsaneh Khodadadi, Baratali Fakheri, Setsuko Komatsu
Organ-specific analyses enrich the understanding of plant growth and development under abiotic stresses. To elucidate the cellular responses in soybean seedlings exposed to flooding and drought stresses, organ-specific analysis was performed using a gel-free/label-free proteomic technique. Physiological analysis indicated that enzyme activities of alcohol dehydrogenase and delta-1-pyrroline-5-carboxylate synthase were markedly increased in leaf and root of plants treated with 6days of flooding and drought stresses, respectively...
April 18, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28435103/magnetization-transfer-contrast-and-chemical-exchange-saturation-transfer-mri-features-and-analysis-of-the-field-dependent-saturation-spectrum
#16
Peter C M van Zijl, Wilfred W Lam, Jiadi Xu, Linda Knutsson, Greg J Stanisz
Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation Transfer (CEST) experiments measure the transfer of magnetization from molecular protons to the solvent water protons, an effect that becomes apparent as an MRI signal loss ("saturation"). This allows molecular information to be accessed with the enhanced sensitivity of MRI. In analogy to Magnetic Resonance Spectroscopy (MRS), these saturation data are presented as a function of the chemical shift of participating proton groups, e.g. OH, NH, NH2, which is called a Z-spectrum...
April 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28433698/adipose-crosstalk-with-other-cell-types-in-health-and-disease
#17
REVIEW
Chan Hee J Choi, Paul Cohen
In addition to storing and mobilizing energy, adipocytes secrete circulating factors to signal to other tissues and coordinate energy metabolism. These functions can become disrupted in the setting of obesity, contributing to the development of diabetes, cardiovascular disease, and cancer. Since the discovery of leptin and adiponectin, an increasing number of adipokines have been identified and their functions elucidated. More recent studies have highlighted other modes by which adipose tissue can participate in crosstalk with other cell types and tissues...
April 19, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28433042/-alarmins-and-surgical-injury
#18
J Máca, M Peteja
Surgical intervention is an inseparable part of the management of serious surgical disease. However, surgery also presents a potential risk related to the so-called surgical injury causing immune response. When dysregulated the immune activation is able to cause local complications (i.e. wound dehiscence, impaired healing). Systemic decompartmentization of the immunologic disturbance can negatively influence long-term outcomes (i.e. hospital length of stay, mortality). Due to aseptic conditions in the operating room, such an immune activation is almost always of sterile nature...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28432787/presynaptic-morphology-and-vesicular-composition-determine-vesicle-dynamics-in-mouse-central-synapses
#19
Laurent Guillaud, Dimitar Dimitrov, Tomoyuki Takahashi
Transport of synaptic vesicles (SVs) in nerve terminals is thought to play essential roles in maintenance of neurotransmission. To identify factors modulating SV movements, we performed real-time imaging analysis of fluorescently labeled SVs in giant calyceal and conventional hippocampal terminals. Compared with small hippocampal terminals, SV movements in giant calyceal terminals were faster, longer and kinetically more heterogeneous. Morphological maturation of giant calyceal terminals was associated with an overall reduction in SV mobility and displacement heterogeneity...
April 22, 2017: ELife
https://www.readbyqxmd.com/read/28432663/the-vascular-wall-a-plastic-hub-of-activity-in-cardiovascular-homeostasis-and-disease
#20
REVIEW
Cassandra P Awgulewitsch, Linh T Trinh, Antonis K Hatzopoulos
PURPOSE OF REVIEW: This review aims to summarize recent findings regarding the plasticity and fate switching among somatic and progenitor cells residing in the vascular wall of blood vessels in health and disease. RECENT FINDINGS: Cell lineage tracing methods have identified multiple origins of stem cells, macrophages, and matrix-producing cells that become mobilized after acute or chronic injury of cardiovascular tissues. These studies also revealed that in the disease environment, resident somatic cells become plastic, thereby changing their stereotypical identities to adopt proinflammatory and profibrotic phenotypes...
June 2017: Current Cardiology Reports
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