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N G Fischer, A Tsujimoto, A G Baruth
OBJECTIVE: Limited information is available on how to polish and finish zirconia surfaces following computer-aided design/computer-aided manufacturing (CAD/CAM), specifically, how differing application forces and reuse of zirconia polishing systems affect zirconia topography. PURPOSE: To determine the effect of differing, clinically relevant, polishing application forces and multiple usages of polishing burs on the surface topography of CAD/CAM zirconia. METHODS: One hundred twenty 220-grit carbide finished zirconia disks were sintered according to manufacturer's directions and divided into two groups for the study of two coarse polishing bur types...
March 16, 2018: Operative Dentistry
Hugh M Gloster
The following is a response to the Letter to the Editor by Konda, Francis, and Patel regarding the article "Mohs and Close" Technique (MCT) for selected cases to increase the efficiency of Mohs micrographic surgery.1,2 The letter raises questions about our utilization of MCT that require clarification.
March 1, 2018: Journal of Drugs in Dermatology: JDD
Carlin Geor Malar, Muthulingam Seenuvasan, Kannaiyan Sathish Kumar
Herein, the magnetite nanoparticles (MNs) were prepared by facile solvothermal method and its porous nature was modified using 3-(2-aminoethyl)-3-aminopropyl trimethoxysilane (AEAPS). Magnetite formation, successful amino tagging, and urease conjugation on the surface were confirmed from the presence of certain functional groups in Fourier transform infrared (FT-IR) spectra. Also, nanosize (13.2 nm) and spherical morphology of MNs were evaluated from diffraction patterns and electron micrographs respectively...
March 14, 2018: Applied Biochemistry and Biotechnology
Diana Wrigley de Basanta, Arturo Estrada-Torres, Iván García-Cunchillos, Asunción Cano Echevarría, Carlos Lado
A new species of Didymium (Myxomycetes), D. azorellae, isolated from plant debris in a moist chamber, collected during studies of cold arid areas of Argentina and Peru, is described. It can be distinguished by its small size, the tightly packed layer of lime crystals on the peridium, the very scant, or absent, capillitium, and the unique spore ornamentation, especially by scanning electron microscopy. The species developed on dead leaves of cushion plants growing in the extremely harsh environments of the central Andean puna at almost 5000 m elevation and the Andino-Patagonian steppe...
January 25, 2018: Mycologia
Bruno Henriques, Douglas Fabris, Júlio C M Souza, Filipe S Silva, Óscar Carvalho, Márcio C Fredel, Joana Mesquita-Guimarães
OBJECTIVES: The aim of this study was to evaluate the effect of laser surface structuring on the bond strength of feldspar-based porcelain to zirconia, as compared to conventional sandblasting treatment. MATERIALS AND METHODS: Thirty cylindrical zirconia substrates, previously sintered, were divided in three groups according to the type of surface conditioning: 1) sandblasting with 50 µm Al2 O3 ; 2) laser structuring (Ø25 µm holes); and 3) laser structuring (Ø50 µm holes)...
February 27, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Richard Boyle, Reza Ehsanian, Alireza Mofrad, Yekaterina Popova, Joseph Varelas
The utricle provides the vestibular reflex pathways with the sensory codes of inertial acceleration of self motion and head orientation with respect to gravity to control balance and equilibrium. Here we present an anatomical description of this structure in the adult oyster toadfish, and establish a morphological basis for interpretation of subsequent functional studies. Light, scanning and transmission electron microscopy techniques were applied to visualize the sensory epithelium at varying levels of detail, its neural innervation and its synaptic organization...
March 10, 2018: Journal of Comparative Neurology
Junqian Zhang, Christopher J Miller, Victoria O'Malley, Jeremy R Etzkorn, Thuzar M Shin, Joseph F Sobanko
BACKGROUND: Changes in patient perceptions of quality of life (QOL) after Mohs micrographic surgery (MMS) may benefit from different counseling or treatment. OBJECTIVE: To measure QOL before and after MMS and to identify risk factors associated with impaired QOL. METHODS: Prospective observational study of 727 skin cancer patients who self-reported QOL via the Skin Cancer Index immediately before and at 1-2 weeks and 3 months after MMS. RESULTS: QOL fluctuated after MMS...
March 5, 2018: Journal of the American Academy of Dermatology
David E Timm, Valorie Bowman, Russell Madsen, Charles Rauch
Protein arginine methyl transferase 5 (PRMT5) is a signaling protein and histone modifying enzyme that is important in many cellular processes, including regulation of eukaryotic gene transcription. Reported here is a 3.7 Å structure of PRMT5, solved in complex with regulatory binding subunit MEP50 (methylosome associated protein 50, WDR77, p44), by single particle (SP) cryo-Electron Microscopy (cryo-EM) using micrographs of particles that are visibly crowded and aggregated. Despite suboptimal micrograph appearance, this cryo-EM structure is in good agreement with previously reported crystal structures of the complex, which revealed a 450 kDa hetero-octameric assembly having internal D2 symmetry...
2018: PloS One
Ali A Damavandy, Vitaly Terushkin, John A Zitelli, David G Brodland, Christopher J Miller, Jeremy R Etzkorn, Thuzar M Shin, Mark A Cappel, Mario Mitkov, Ali Hendi
BACKGROUND: Extramammary Paget's disease (EMPD) is a rare intraepithelial malignancy with high recurrence rates following standard surgical treatments, ranging from 22% to 60% in large retrospective reviews. OBJECTIVE: To evaluate the local recurrence rate of Mohs micrographic surgery (MMS) supplemented with intraoperative immunohistochemistry for cytokeratin-7 (MMS + CK-7) for primary and recurrent EMPD. MATERIALS AND METHODS: Retrospective, multi-center, cross-sectional study of patients treated using MMS + CK-7...
March 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Tiffany F Keenan-Bateman, William A McLellan, Alex M Costidis, Craig A Harms, D Mark Gay, David S Rotstein, Sentiel A Rommel, Charles W Potter, D Ann Pabst
The giant (>3 m) parasitic nematode Crassicauda magna infects kogiid whales, although only 3 studies to date have provided detailed descriptions of these worms, all based upon fragmented specimens. These fragments were found within the neck region of kogiids, an unusual anatomic site for this genus of parasites. C. magna is a species-specific parasite among kogiids, infecting only pygmy sperm whales Kogia breviceps, and with a primarily cervico-thoracic distribution. To date, however, the pattern of habitat use within the host and transmission path of this parasite remain unknown...
March 5, 2018: Diseases of Aquatic Organisms
Alexander J Knowles, Tea-Sung Jun, Ayan Bhowmik, Nicholas G Jones, T Ben Britton, Finn Giuliani, Howard J Stone, David Dye
The data presented in this article are related to the research article entitled "a new beta titanium alloy system reinforced with superlattice intermetallic precipitates" (Knowles et al., 2018) [1]. This includes data from the as-cast alloy obtained using scanning electron microscopy (SEM) and x-ray diffraction (XRD) as well as SEM data in the solution heat treated condition. Transmission electron microscopy (TEM) selected area diffraction patterns (SADPs) are included from the alloy in the solution heat treated condition, as well as the aged condition that contained < 100 nm B2 TiFe precipitates [1], the latter of which was found to exhibit double diffraction owing to the precipitate and matrix channels being of a similar width to the foil thickness (Williams and Carter, 2009) [2]...
April 2018: Data in Brief
Miriam Buttacavoli, Nadia Ninfa Albanese, Gianluca Di Cara, Rosa Alduina, Claudia Faleri, Michele Gallo, Giuseppe Pizzolanti, Giuseppe Gallo, Salvatore Feo, Franco Baldi, Patrizia Cancemi
Silver nanoparticles (AgNPs), embedded into a specific polysaccharide (EPS), were biogenerated by Klebsiella oxytoca DSM 29614 under aerobic (AgNPs-EPSaer ) and anaerobic conditions (AgNPs-EPSanaer ). Both AgNPs-EPS matrices were tested by MTT assay for cytotoxic activity against human breast (SKBR3 and 8701-BC) and colon (HT-29, HCT 116 and Caco-2) cancer cell lines, revealing AgNPs-EPSaer as the most active, in terms of IC50, with a more pronounced efficacy against breast cancer cell lines. Therefore, colony forming capability, morphological changes, generation of reactive oxygen species (ROS), induction of apoptosis and autophagy, inhibition of migratory and invasive capabilities and proteomic changes were investigated using SKBR3 breast cancer cells with the aim to elucidate AgNPs-EPSaer mode of action...
February 9, 2018: Oncotarget
Timothy Grant, Alexis Rohou, Nikolaus Grigorieff
We have developed new open-source software called cis TEM (computational imaging system for transmission electron microscopy) for the processing of data for high-resolution electron cryo-microscopy and single-particle averaging. cis TEM features a graphical user interface that is used to submit jobs, monitor their progress, and display results. It implements a full processing pipeline including movie processing, image defocus determination, automatic particle picking, 2D classification, ab-initio 3D map generation from random parameters, 3D classification, and high-resolution refinement and reconstruction...
March 7, 2018: ELife
Felipe Bochnia Cerci
Mohs micrographic surgery (MMS) is the treatment of choice for high-risk basal cell carcinoma.1,2 The technique combines tissue conservation with complete microscopic margin control, leading to superior cure rates while minimizing deformity.3 MMS involves several steps that should be meticulously followed to achieve this high cure rate.4 This article is protected by copyright. All rights reserved.
March 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Jihua Wu, Zhiwei Tao, Yaoliang Deng, Quan Liu, Yunlong Liu, Xiaofeng Guan, Xiang Wang
Calcifying nanoparticles (CNPs) play an important role in kidney stone formation, but the mechanism(s) are unclear. CNPs were isolated and cultured from midstream urine of patients with kidney stones. CNP morphology and characteristics were examined by electron microscopy and electrophoresis analysis. Chemical composition was analyzed using energy-dispersive X-ray microanalysis and Western blotting. Human renal proximal convoluted tubule cell (HK-2) cultures were exposed to CNPs for 0, 12 and 72 h, and production of reactive oxygen species (ROS), mitochondrial membrane potential and apoptosis levels were evaluated...
March 6, 2018: Urolithiasis
Jeremy R Etzkorn, Scott D Tuttle, Ilya Lim, Elea M Feit, Joseph F Sobanko, Thuzar M Shin, Donald E Neal, Christopher J Miller
BACKGROUND: Surgical treatment options for facial melanomas include conventional excision with postoperative margin assessment (CE-POMA), Mohs micrographic surgery with immunostains (MMS-I) or slow Mohs. Patient preferences for these surgical options have not been studied. OBJECTIVES: To evaluate patient preferences for surgical treatment of facial melanoma and to determine how patients value the relative importance of different surgical attributes. METHODS: Participants completed a two-part study consisting of a stated preference survey and a choice-based conjoint analysis (CBCA) experiment...
March 2, 2018: Journal of the American Academy of Dermatology
Ling-Ling Ying, De-Yin Wang, Hui-Ping Yang, Xi-Yan Deng, Chao Peng, Chao Zheng, Bei Xu, Lin-Yi Dong, Xu Wang, Liang Xu, Yan-Wen Zhang, Xian-Hua Wang
A combination between modification with porous layer and grafting of polyethyleneimine (PEI) on the inner face of capillary was for the first time developed for boronate affinity in-tube solid-phase microextraction (SPME) material to enhance the extraction capacity for cis-diol-containing polyphenols. The successful synthesis of boronate-decorated polyethyleneimine-grafted porous layer open tubular (BPPLOT) capillary was confirmed by scanning electron micrograph, Fourier transform-infrared spectra and absorption experiments...
February 21, 2018: Journal of Chromatography. A
Siavash Maraghechi, Johan P M Hoefnagels, Ron H J Peerlings, Marc G D Geers
High resolution scanning electron microscopy (HR-SEM) is nowadays very popular for different applications in different fields. However, SEM images may exhibit a considerable amount of imaging artifacts, which induce significant errors if the images are used to measure geometrical or kinematical fields. This error is most pronounced in case of full field deformation measurements, for instance by digital image correlation (DIC). One family of SEM artifacts result from positioning errors of the scanning electron beam, creating artifactual shifts in the images perpendicular to the scan lines (scan line shifts)...
February 3, 2018: Ultramicroscopy
Hossein Ali Rangkooy, Fatemeh Tanha, Neamat Jaafarzadeh, Abolfazl Mohammadbeigi
The present study examined the gas-phase photocatalytic degradation of toluene using ZnO-SnO2 nanocomposite supported on activated carbon in a photocatalytic reactor. Toluene was selected as a model pollutant from volatile organic compounds to determine the pathway of photocatalytic degradation and the factors influencing this degradation. The ZnO-SnO2 nanocomposite was synthesized through co-precipitation method in a ratio of 2:1 and then supported on activated carbon. The immobilization of ZnO-SnO2 nanocomposite on activated carbon was determined by the surface area and scanning electron micrograph technique proposed by Brunauer, Emmett, and Teller...
October 2017: Medical Gas Research
Minjun Yang, Ruina Zhi, Lu Lu, Mingxin Dong, Yuzhu Wang, Fang Tian, Minjie Xia, Jingying Hu, Qiuyun Dai, Shibo Jiang, Weihua Li
B07 is a small-molecule CCR5 antagonist-based HIV-1 entry inhibitor that is being developed as an anti-HIV microbicide for preventing sexual transmission of HIV. Here we evaluated its spermicidal and contraceptive potential, including sperm motility, plasma membrane integrity, and contraceptive efficacy tested in rabbits. We found that B07 inhibited sperm motility and movement patterns in a concentration- and time-dependent manner. Within 30 min, B07 induced sperm immobilization with the minimum 100% effective concentration and median effective concentration of 640...
February 26, 2018: European Journal of Pharmaceutical Sciences
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