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https://www.readbyqxmd.com/read/28934278/intercalated-disc-in-failing-hearts-from-patients-with-dilated-cardiomyopathy-its-role-in-the-depressed-left-ventricular-function
#1
Ana Ortega, Estefanía Tarazón, Carolina Gil-Cayuela, María García-Manzanares, Luis Martínez-Dolz, Francisca Lago, José Ramón González-Juanatey, Juan Cinca, Esther Jorge, Manuel Portolés, Esther Roselló-Lletí, Miguel Rivera
Alterations in myocardial structure and reduced cardiomyocyte adhesions have been previously described in dilated cardiomyopathy (DCM). We studied the transcriptome of cell adhesion molecules in these patients and their relationships with left ventricular (LV) function decay. We also visualized the intercalated disc (ID) structure and organization. The transcriptomic profile of 23 explanted LV samples was analyzed using RNA-sequencing (13 DCM, 10 control [CNT]), focusing on cell adhesion genes. Electron microscopy analysis to visualize ID structural differences and immunohistochemistry experiments of ID proteins was also performed...
2017: PloS One
https://www.readbyqxmd.com/read/28931488/carboxylate-cross-linked-cyclodextrin-a-nanoporous-scaffold-for-enhancement-of-rosuvastatin-oral-bioavailability
#2
Mai Mahmoud Gabr, Sana Mohamed Mortada, Marwa Ahmed Sallam
Cyclodextrins play an important role in supramolecular chemistry acting as building blocks than can be cross-linked by various linker molecules forming nano-porous structures called nanosponges (NS). NS have the ability to enhance the stability, solubility and bioavailability of various actives. This work aimed at elaborating rosuvastatin (ROS) loaded NS to improve its oral bioavailability. Carboxylate-linked NS were synthesized by reacting β-CD with pyromellitic dianhydride (PDA) at different molar ratios under specific conditions...
September 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28930787/use-of-google-trends-to-examine-interest-in-mohs-micrographic-surgery-2004-to-2016
#3
Daniel J Callaghan
BACKGROUND: Mohs micrographic surgery (MMS) is the gold standard for treatment of high-risk skin cancers. There has been an upward trend in the use of this procedure as demonstrated by data from Medicare and the National Ambulatory Medical Care Survey. OBJECTIVE: To assess interest in MMS among members of the general public as measured by number of online searches, and how that interest has changed over time. MATERIALS AND METHODS: Google Trends was used to plot interest in search terms including "Mohs surgery," "basal cell carcinoma," "squamous cell carcinoma," "melanoma," and "skin cancer" from January 1, 2004, to November 30, 2016...
September 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28928525/structural-changes-evaluation-with-raman-spectroscopy-in-meat-batters-prepared-by-different-processes
#4
Zhuang-Li Kang, Xiang Li, Hong-Ju He, Han-Jun Ma, Zhao-Jun Song
A comprehensive study was conducted to evaluate the structural changes of meat and protein of pork batters produced by chopping or beating process through the phase-contrast micrograph, laser light scattering analyzer, scanning electronic microscopy and Raman spectrometer. The results showed that the shattered myofibrilla fragments were shorter and particle-sizes were smaller in the raw batter produced by beating process than those in the chopping process. Compared with the raw and cooked batters produced by chopping process, modifications in amide I and amide III bands revealed a significant decrease of α-helix content and an increase of β-sheet, β-turn and random coils content in the beating process...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28928501/relationships-between-structural-fat-properties-with-sensory-physical-and-textural-attributes-of-yeast-leavened-laminated-salty-baked-product
#5
Ana E de la Horra, Gabriela N Barrera, Eugenia M Steffolani, Pablo D Ribotta, Alberto E León
The aim of this study was to establish relationships between structural fat properties and sensory, physical and textural attributes of yeast-leavened laminated salty products. Refined bovine fat (MG1) and shortening (MG2), with a solid fat content (SFC) higher than 20% at temperature range of 15-35 °C were more viscous and less sensitive to temperature changes. The micrographs of dough|fat|dough sections corresponding to samples with MG1 and MG2 revealed a lower penetration of the fat sheet in the dough section due to the more entangled fat structures that did not allow a great flow throughout the dough layer...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28924976/spontaneous-generation-of-a-novel-foetal-human-retinal-pigment-epithelium-rpe-cell-line-available-for-investigation-on-phagocytosis-and-morphogenesis
#6
Zhihua Shao, Haiyun Wang, Xuejian Zhou, Baosen Guo, Xuehu Gao, Zengrong Xiao, Meng Liu, Jihong Sha, Chunlian Jiang, Yuping Luo, Zhixue Liu, Siguang Li
OBJECTIVES: Primary retinal pigment epithelium (RPE) cells have a limited capacity to re-establish epithelial morphology and to maintain native RPE function in vitro, and all commercially available RPE cell lines have drawbacks of morphology or function; therefore, the establishment of new RPE cell lines with typical characteristics of RPE would be helpful in further understanding of their physiological and pathological mechanisms. Here, we firstly report a new spontaneously generated RPE line, fhRPE-13A, from a 13-week aborted foetus...
September 18, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28922052/applications-of-emerging-transmission-electron-microscopy-technology-in-pcd-research-and-diagnosis
#7
Amelia Shoemark
Primary Ciliary Dyskinesia (PCD) is a heterogeneous genetic condition characterized by dysfunction of motile cilia. Patients suffer from chronic infection and inflammation of the upper and lower respiratory tract. Diagnosis of PCD is confirmed by identification of a hallmark defect of ciliary ultrastructure or by identification of biallelic pathogenic mutations in a known PCD gene. Since the first description of PCD in 1976, assessment of ciliary ultrastructure by transmission electron microscopy (TEM) has been central to diagnosis and research...
September 18, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28921913/high-resolution-imaging-of-muscle-attachment-structures-in-c-elegans
#8
Hiroshi Qadota, Yohei Matsunaga, Ken C Q Nguyen, Alexa Mattheyses, David H Hall, Guy M Benian
We used structured illumination microscopy (SIM) to obtain super-resolution images of muscle attachment structures in C. elegans striated muscle. SIM imaging of M-line components revealed two patterns: PAT-3 (β-integrin) and proteins that interact in a complex with the cytoplasmic tail of β-integrin and localize to the basal muscle cell membrane (UNC-112 (kindlin), PAT-4 (ILK), UNC-97 (PINCH), PAT-6 (α-parvin) and UNC-95), are found in discrete, angled segments with gaps. In contrast, proteins localized throughout the depth of the M-line (UNC-89 (obscurin) and UNC-98) are imaged as continuous lines...
September 16, 2017: Cytoskeleton
https://www.readbyqxmd.com/read/28918134/crystallization-and-demineralization-phenomena-in-washed-rind-cheese
#9
Gil F Tansman, Paul S Kindstedt, John M Hughes
This report documents an observational study of a high-moisture washed-rind cheese. Three batches of cheese were sampled on a weekly basis for 6 wk and again at wk 10. Center, under-rind, rind, and smear samples were tested for pH, moisture, and selected mineral elements. Powder x-ray diffractometry and petrographic microscopy were applied to identify and image the crystal phases. The pH of the rind increased by over 2 pH units by wk 10. The pH of the under-rind increased but remained below the rind pH, whereas the center pH decreased for most of aging and only began to rise after wk 5...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28917477/using-a-slit-knife-to-facilitate-mohs-micrographic-surgery-in-irregularly-shaped-areas
#10
José Francisco Millán-Cayetano, Inés Fernández-Canedo, Alberto Ortega-Sánchez, Magdalena de Troya-Martín
No abstract text is available yet for this article.
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28914537/coupling-bioflocculation-of-dehalococcoides-mccartyi-to-high-rate-reductive-dehalogenation-of-chlorinated-ethenes
#11
Anca G Delgado, Devyn Fajardo-Williams, Emily Bondank, Sofia Esquivel-Elizondo, Rosa Krajmalnik-Brown
Continuous bioreactors operated at low hydraulic retention times have rarely been explored for reductive dehalogenation of chlorinated ethenes. The inability to consistently develop such bioreactors affects the way growth approaches for Dehalococcoides mccartyi bioaugmentation cultures are envisioned. It also affects interpretation of results from in situ continuous treatment processes. We report bioreactor performance and dehalogenation kinetics of a D. mccartyi-containing consortium in an upflow bioreactor...
September 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28913393/data-for-automated-high-throughput-microscopy-analysis-of-intracellular-bacterial-colonies-using-spot-detection
#12
Christina L Ernstsen, Frédéric H Login, Helene H Jensen, Rikke Nørregaard, Jakob Møller-Jensen, Lene N Nejsum
Quantification of intracellular bacterial colonies is useful in strategies directed against bacterial attachment, subsequent cellular invasion and intracellular proliferation. An automated, high-throughput microscopy-method was established to quantify the number and size of intracellular bacterial colonies in infected host cells (Detection and quantification of intracellular bacterial colonies by automated, high-throughput microscopy, Ernstsen et al., 2017 [1]). The infected cells were imaged with a 10× objective and number of intracellular bacterial colonies, their size distribution and the number of cell nuclei were automatically quantified using a spot detection-tool...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28910874/-expression-of-c3d-in-normal-human-liver-tissues-with-non-immunologic-osmostic-mechanism
#13
H J Huang, C Y Feng, Z Y Zheng
Objective: To observe the deposition of complement C3d at different development stages in human normal organs and tissues, and investigate the significance of its deposition. Methods: Using immunohistochemical methods, the deposition of C3d was detected at different development stages of 60 normal human organs and tissue specimens and double staining was performed in some specimens. Ninty-five cases of other organs or tissues were collected as control group. Results: In 50 of 60 livers, it was observed the deposition of C3d in Glisson's capsule and periportal sheath, with irregular linear network-like disposition surrounding the portal sheath...
September 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28906595/superiority-of-occipital-donor-sites-for-split-thickness-skin-grafting-in-dermatosurgery-results-of-a-prospective-randomized-controlled-study
#14
Maximilian Kovacs, Syrus Karsai, Maurizio Podda
BACKGROUND: Split-thickness skin grafts are commonly used in dermatosurgery. For occipital donor sites, retrospective studies have shown good results with respect to graft take and healing rates. Nevertheless, the majority of grafts in dermatosurgery are harvested from the thigh. To date, there has been no prospective randomized controlled study comparing occipital versus femoral donor sites. PATIENTS AND METHODS: Following micrographically controlled R0 tumor resection, 108 patients were randomized prior to undergoing split-thickness skin grafting (donor site: occiput vs...
September 14, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28906515/study-of-the-presence-of-spherical-deformations-on-the-al-top-electrode-due-to-electroforming-in-rewritable-organic-resistive-memories
#15
J A Ávila-Niño, M Reyes-Reyes, R López-Sandoval
Physical deformations are observed at the top electrodes during the electroforming process in Al/PEDOT:PSS + nitrogen doped multiwalled carbon nanotube (N-MWCNTs)/Al rewritable resistive memory devices. These physical deformations arise from electrochemical reactions, i.e., a reduction reaction in the native Al oxide layer, which are similar to those reported in TiO2-based resistive memory devices. These memory devices are electroformed at the ON state using an ∼-2 V pulse or at the OFF state using an ∼3 V pulse...
September 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28900834/coq10-increases-mitochondrial-mass-and-polarization-atp-and-oct4-potency-levels-and-bovine-oocyte-mii-during-ivm-while-decreasing-ampk-activity-and-oocyte-death
#16
M K Abdulhasan, Q Li, J Dai, H M Abu-Soud, E E Puscheck, D A Rappolee
PURPOSE: We tested whether mitochondrial electron transport chain electron carrier coenzyme Q10 (CoQ10) increases ATP during bovine IVM and increases %M2 oocytes, mitochondrial polarization/mass, and Oct4, and decreases pAMPK and oocyte death. METHODS: Bovine oocytes were aspirated from ovaries and cultured in IVM media for 24 h with 0, 20, 40, or 60 μM CoQ10. Oocytes were assayed for ATP by luciferase-based luminescence. Oocyte micrographs were quantitated for Oct4, pAMPK (i...
September 12, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28898467/mohs-micrographic-surgery-in-the-elderly-comparison-of-tumours-surgery-and-first-year-follow-up-in-patients-younger-and-older-than-80-years-old-in-regesmohs
#17
C Camarero-Mulas, Y Delgado Jiménez, O Sanmartín-Jiménez, J R Garcés, M A Rodríguez-Prieto, T Alonso-Alonso, R Miñano Medrano, J L López-Estebaranz, E de Eusebio Murillo, P Redondo, C Ciudad-Blanco, A Toll-Abelló, J L Artola Igarza, I Allende Markixana, R Suarez Fernández, A Alfaro Rubio, M L Alonso Pacheco, H Vázquez-Veiga, P de la Cueva Dobao, V Ruiz-Salas, E Vilarrasa Rull, L Barchino, V Morales-Gordillo, I Ocerin-Guerra, R Navarro Tejedor, L Hueso, M Mayor Arenal, M J Seoane-Pose, N Cano-Martinez, I Garcia-Doval, M A Descalzo
BACKGROUND: The elderly population is increasing and more patients in this group undergo Mohs micrographic surgery. The few publications investigating MMS in elderly people conclude that it is a safe procedure; however, these are single centre studies without a comparison group. OBJECTIVE: To compare the characteristics of patients, tumours, MMS, and one-year follow-up in patients younger than 80 years, with patients older than 80 years at the time of surgery. METHODS: Data was analysed from REGESMOHS, a prospective cohort study of patients treated with MMS...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28895509/mycoplasma-tullyi-sp-nov-isolated-from-penguins-of-the-genus-spheniscus
#18
Christine A Yavari, Ana S Ramírez, Robin A J Nicholas, Alan D Radford, Alistair C Darby, Janet M Bradbury
A mycoplasma isolated from the liver of a dead Humboldt penguin (Spheniscus humboldti) and designated strain 56A97T, was investigated to determine its taxonomic status. Complete 16S rRNA gene sequence analysis indicated that the organism was most closely related to Mycoplasma gallisepticum and Mycoplasma imitans(99.7 and 99.9 % similarity, respectively). The average DNA-DNA hybridization values between strain 56A97T and M. gallisepticum and M. imitans were 39.5 and 30 %, respectively and the Genome to Genome Distance Calculator gave results of 29...
September 12, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28894295/reversible-naftifine-induced-carotenoid-depigmentation-in-rhodotorula-mucilaginosa-a-j%C3%A3-rg-f-c-harrison-causing-onychomycosis
#19
Augustin C Moț, Marcel Pârvu, Alina E Pârvu, Oana Roşca-Casian, Nicoleta E Dina, Nicolae Leopold, Radu Silaghi-Dumitrescu, Cristina Mircea
Rhodotorula mucilaginosa was isolated from a patient with onychomycosis, and identification was confirmed by morphological and cultural characteristics as well as by DNA molecular analysis. Antifungal agents naftifine (10 mg/mL, active substance in Exoderil) and bifonazole (10 mg/mL, active substance in Canespor) were tested in different concentrations to assess in vitro effects on fungal growth and carotenoid synthesis. The antifungal mechanisms of action of naftifine and bifonazole against R. mucilaginosa isolates were similar and affected the biosynthetic pathway of ergosterol...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28894108/description-of-two-three-gendered-nematode-species-in-the-new-genus-auanema-rhabditina-that-are-models-for-reproductive-mode-evolution
#20
Natsumi Kanzaki, Karin Kiontke, Ryusei Tanaka, Yuuri Hirooka, Anna Schwarz, Thomas Müller-Reichert, Jyotiska Chaudhuri, Andre Pires-daSilva
The co-existence of males, females and hermaphrodites, a rare mating system known as trioecy, has been considered as an evolutionarily transient state. In nematodes, androdioecy (males/hermaphrodites) as found in Caenorhabditis elegans, is thought to have evolved from dioecy (males/females) through a trioecious intermediate. Thus, trioecious species are good models to understand the steps and requirements for the evolution of new mating systems. Here we describe two new species of nematodes with trioecy, Auanema rhodensis and A...
September 11, 2017: Scientific Reports
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