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https://www.readbyqxmd.com/read/29786952/arabidopsis-sumo-protease-asp1-positively-regulates-aba-signaling-during-early-seedling-development
#1
Qiongli Wang, Gao-Ping Qu, Xiangxiong Kong, Yan Yan, Jigang Li, Jing Bo Jin
The small ubiquitin-related modifier (SUMO) modification plays an important role in the regulation of abscisic acid (ABA) signaling, but the function of the SUMO protease, in ABA signaling, remains largely unknown. Here, we show that the SUMO protease, ASP1 positively regulates ABA signaling. Mutations in ASP1 resulted in an ABA-insensitive phenotype, during early seedling development. Wild-type ASP1 successfully rescued, whereas an ASP1 mutant (C577S), defective in SUMO protease activity, failed to rescue, the ABA-insensitive phenotype of asp1-1...
May 22, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29786943/integrating-a-comprehensive-dna-barcode-reference-library-with-a-global-map-of-yews-taxus-l-for-forensic-identification
#2
Jie Liu, Richard I Milne, Michael Möller, Guang-Fu Zhu, Lin-Jiang Ye, Ya-Huang Luo, Jun-Bo Yang, Moses Cheloti Wambulwa, Chun-Neng Wang, De-Zhu Li, Lian-Ming Gao
Rapid and accurate identification of endangered species is a critical component of bio-surveillance and conservation management, and potentially policing illegal trades. However, this is often not possible using traditional taxonomy, especially where only small or pre-processed parts of plants are available. Reliable identification can be achieved via a comprehensive DNA barcode reference library, accompanied by precise distribution data. However, these require extensive sampling at spatial and taxonomic scales, which has rarely been achieved for cosmopolitan taxa...
May 22, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29786687/genome-wide-analysis-of-circular-rnas-in-bovine-cumulus-cells-treated-with-bmp15-and-gdf9
#3
Yao Fu, Hao Jiang, Jian-Bo Liu, Xu-Lei Sun, Zhe Zhang, Sheng Li, Yan Gao, Bao Yuan, Jia-Bao Zhang
Circular RNAs (circRNAs) are important members of the non-coding RNA family, and those relating to animal physiologies have been widely studied in recent years. This study aimed to explore the roles of circRNAs in the regulation of follicular development. We constructed four bovine cumulus cell cDNA libraries, including a negative control group (NC) and groups treated with BMP15, GDF9 and BMP15 + GDF9, and we sequenced the libraries on the Illumina HiSeq Xten platform. We identified 1706 circRNAs and screened for differential circRNA expression...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29786668/scf-c-kit-signaling-increased-mucin2-production-by-maintaining-atoh1-expression-in-mucinous-colorectal-adenocarcinoma
#4
Ping Shen, Shu Yang, Haimei Sun, Guilan Li, Bo Wu, Fengqing Ji, Tingyi Sun, Deshan Zhou
Mucinous colorectal adenocarcinoma (MCA) patients often a show high risk of malignant potential and a poorer survival rate. Given that the pathological feature and oncobiological characteristics of MCA are correlated with its abundant extracellular mucin2 (MUC2), we paid interest toward investigating the key factor that promotes MUC2 production exposure to highly-activated stem cell factor (SCF)/c-KIT signaling, which we believed to contribute to MCA formation. Long-term azoxymethane and dextran sodium sulfate treatment successfully induced MCA only in wild-type (WT) mice at week 37 and 43, while all c-kit loss-of-function mutant mice (Wadsm/m ) developed non-MCA...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29786615/morphological-control-of-gold-nanorods-via-thermally-driven-bi-surfactant-growth-and-application-for-detection-of-heavy-metal-ions
#5
Hao Huang, Huiyi Li, Huaiyu Wang, Jia Li, Penghui Li, Qidan Chen, Yue Chen, Paul K Chu, Bo Li, Xuefeng Yu
We report a modified synthesis route of colloidal gold nanorods (AuNRs) by combining the thermal re-shaping treatment and bi-surfactant modification using hexadecyltrimethylammonium bromide (CTAB) and sodium oleate (NaOL). Aspect ratios down to 1.3 ± 0.1 can be achieved in addition to good monodispersity, uniformity, and chemical stability of the materials. Furthermore, without needing post-treatment, metal ions directly interact with the AuNRs efficiently, allowing rapid and sensitive colorimetric detection of heavy metal ions such as Pb<sup>2+</sup> and Cu<sup>2+</sup> with a low concentration down to 2...
May 22, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29786452/identification-of-a-novel-hiv-1-unique-recombinant-form-composed-of-crf01_ae-subtype-b-and-crf65_cpx-among-men-who-have-sex-with-men-in-jilin-china
#6
Yuan-Long Lin, Bo Song, Bing Shao, Si-Yu Liu, Qing-Qing Huo, Jin Li, Jia-Ye Wang, Fu-Xiang Wang
Current HIV-1 epidemic in China is featured by diverse subtypes and continual emergence of new recombinant viruses. This study identified a novel unique recombinant form (URF) JL16013 among men who has sex with men (MSM) in Jilin, China. The JL16013 virus was different from all known subtypes and set up a distinct branch on the phylogenetic tree. This virus had a CRF01_AE backbone with two subtype B' fragments and one CRF65_cpx fragment inserted into gag, pol, env and nef regions, suggesting that this novel URF might originated from the CRF01_AE, subtype B' and CRF65_cpx viruses that were co-circulating in Jilin province...
May 22, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29786447/thickness-tunable-synthesis-of-ultrathin-type-ii-dirac-semimetal-ptte-2-single-crystals-and-their-thickness-dependent-electronic-properties
#7
Huifang Ma, Peng Chen, Bo Li, Jia Li, Ruoqi Ai, Zhengwei Zhang, Guangzhuang Sun, Kangkang Yao, Zhaoyang Lin, Bei Zhao, Ruixia Wu, Xuwan Tang, Xidong Duan, Xiangfeng Duan
The recent discovery of topological semimetals has stimulated extensive research interest due to their unique electronic properties and novel transport properties related to a chiral anomaly. However, the studies to date are largely limited to bulk crystals and exfoliated flakes. Here, we report the controllable synthesis of ultrathin two-dimensional (2D) platinum telluride (PtTe2 ) nanosheets with tunable thickness and investigate the thickness-dependent electronic properties. We show that PtTe2 nanosheets can be readily grown, using a chemical vapor deposition approach, with a hexagonal or triangular geometry and a lateral dimension of up to 80 μm, and the thickness of the nanosheets can be systematically tailored from over 20 to 1...
May 22, 2018: Nano Letters
https://www.readbyqxmd.com/read/29786445/iron-catalyzed-dehydrative-alkylation-of-propargyl-alcohol-with-alkyl-peroxides-to-form-substituted-1-3-enynes
#8
Changqing Ye, Bo Qian, Yajun Li, Min Su, Daliang Li, Hongli Bao
This paper reports a new method for the generation of substituted 1,3-enynes, whose synthesis by other methods could be a challenge. The dehydrative decarboxylative cascade coupling reaction of propargyl alcohol with alkyl peroxides is enabled by an iron catalyst and alkylating reagents. Primary, secondary, and tertiary alkyl groups can be introduced into 1,3-enynes, affording various substituted 1,3-enynes in moderate to good yields. Mechanistic studies suggest the involvement of a radical-polar crossover pathway...
May 22, 2018: Organic Letters
https://www.readbyqxmd.com/read/29786415/tailoring-crystalline-morphology-by-high-efficiency-nucleating-fiber-towards-high-performance-poly-l-lactide-biocomposites
#9
Tao Gao, Zheng-Min Zhang, Le Li, Rui-Ying Bao, Zhengying Liu, Bang-Hu Xie, Ming-Bo Yang, Wei Yang
In this work, high melting point poly(L-lactide) fiber (hPLLA fiber) with high-efficiency nucleation activity was prepared and introduced into PLLA matrix to prepare fully biodegradable PLLA biocomposites. The highly active nucleating surfaces of hPLLA fiber induced chain ordering and lamellar organization, leading to preferable formation of well-organized PLLA transcrystallinity at the surface of hPLLA fiber in quiescent conditions. The construction of such compact transcrystallinity increased the crystallinity and enhanced the interfacial adhesion, which largely promoted the heat resistance, tensile strength, and barrier property of PLLA biocomposites at a low content of hPLLA fiber...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29786078/targeting-the-upstream-transcriptional-activator-of-pd-l1-as-an-alternative-strategy-in-melanoma-therapy
#10
Bo Zhu, Liming Tang, Shuyang Chen, Chengqian Yin, Shiguang Peng, Xin Li, Tongzheng Liu, Wei Liu, Changpeng Han, Lukasz Stawski, Zhi-Xiang Xu, Guangbiao Zhou, Xiang Chen, Xiumei Gao, Colin R Goding, Nan Xu, Rutao Cui, Peng Cao
Programmed cell death ligand 1 (PD-L1) interacts with programmed cell death protein-1 (PD-1) as an immune checkpoint. Reactivating the immune response by inhibiting PD-L1 using therapeutic antibodies provides substantial clinical benefits in many, though not all, melanoma patients. However, transcriptional suppression of PD-L1 expression as an alternative therapeutic anti-melanoma strategy has not been exploited. Here we provide biochemical evidence demonstrating that ultraviolet radiation (UVR) induction of PD-L1 in skin is directly controlled by nuclear factor E2-related transcription factor 2 (NRF2)...
May 22, 2018: Oncogene
https://www.readbyqxmd.com/read/29786077/tumor-derived-exosomes-promote-tumor-self-seeding-in-hepatocellular-carcinoma-by-transferring-mirna-25-5p-to-enhance-cell-motility
#11
Hao Liu, Wei Chen, Xiao Zhi, En-Jiang Chen, Tao Wei, Jian Zhang, Jian Shen, Li-Qiang Hu, Bin Zhao, Xin-Hua Feng, Xue-Li Bai, Ting-Bo Liang
Tumor self-seeding occurs when circulating malignant cells reinfiltrate the original tumor. The process may breed more aggressive tumor cells, which may contribute to cancer progression. In this study, we observed tumor self-seeding in mouse xenograft models of hepatocellular carcinoma (HCC) for the first time. We confirmed that circulating tumor cell uptake of tumor-derived exosomes, which are increasingly recognized as key instigators of cancer progression by facilitating cell-cell communication, promoted tumor self-seeding by enhancing the invasive and migration capability of recipient HCC cells...
May 22, 2018: Oncogene
https://www.readbyqxmd.com/read/29786050/diagnostic-performance-of-intestinal-fusobacterium-nucleatum-in-colorectal-cancer-a-meta-analysis
#12
Bo-Jian Peng, Chuang-Yu Cao, Wei Li, Yong-Jian Zhou, Yuan Zhang, Yu-Qiang Nie, Yan-Wen Cao, Yu-Yuan Li
Background: Increasing evidence has supported the link of intestinal Fusobacterium nucleatum infection to colorectal cancer (CRC). However, the value of F. nucleatum as a biomarker in CRC detection has not been fully defined. In order to reduce the random error and bias of individual research, this meta-analysis aimed to evaluate the diagnostic performance of intestinal F. nucleatum in CRC patients and provide evidence-based data to clinical practice. Methods: An article search was performed from PubMed, Embase, Cochrane Library, and Web of Science databases up to December 2017, using the following key words: "Fusobacterium nucleatum", "Fusobacterium spp...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29786043/risk-factors-for-recurrence-of-ovarian-endometriosis-in-chinese-patients-aged-45-and-over
#13
Zheng-Xing He, Ting-Ting Sun, Shu Wang, Hong-Hui Shi, Qing-Bo Fan, Lan Zhu, Jin-Hua Leng, Da-Wei Sun, Jian Sun, Jing-He Lang
Background: When considering the issue of recurrence, perimenopausal women may have more dilemma during management comparing with young women, for example, whether to retain the uterus and ovary during surgery, whether it is necessary to add adjuvant medicine treatment after operation, and there is no evidence for reference about using of gonadotropin-releasing hormone agonist. This study aimed to study the risk factors for the recurrence of ovarian endometriosis (EM) in patients aged 45 and over...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785846/d-a-d-typed-hole-transport-materials-for-efficient-perovskite-solar-cells-tuning-photovoltaic-properties-via-the-acceptor-group
#14
Peng Xu, Peng Liu, Yuanyuan Li, Bo Xu, Lars Kloo, Licheng Sun, Yong Hua
Two D-A-D structured hole-transport materials (YN1 and YN2) have been synthesized and used in perovskite solar cells. The two HTMs have low-lying HOMO levels and impressive mobility. PSCs fabricated with YN2 showed a PCE value of 19.27% in ambient air, which is significantly higher than that of Spiro-OMeTAD (17.80%). PSCs based on YN1 showed an inferior PCE of 16.03%. We found that the incorporation of the stronger electron-withdrawing group in the HTM YN2 improves the PCE of PSCs. Furthermore, the YN2-based PSCs exhibit good long-term stability retaining 91...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29785672/aberrant-t-cell-subsets-and-cytokines-expression-profile-in-systemic-lupus-erythematosus
#15
Haiyan Zhou, Bailong Hu, Niwen Huang, Xiangang Mo, Wei Li, Bei Zhang, Bo Wei, Mingzhu Gao, Yiming Wang, Xingde Liu, Joshua Liao
To assess T cell subsets and levels of chemokines and cytokines in patients with SLE and determine their relationships between disease activity and organ involvement. Blood samples from SLE patients (n = 24) and healthy controls (n = 36) were analyzed. Frequency of circulating follicular help T cells (Tfh), central memory T cells (Tcm), effector memory T cells (Tem), and naïve T cell subsets was enumerated and their surface markers expression of inducible T cell co-stimulator (ICOS) and programmed death 1(PD-1) protein was examined by flow cytometry...
May 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29785615/molecular-characterization-of-proton-beam-induced-mutations-in-soybean-using-genotyping-by-sequencing
#16
Woon Ji Kim, Jaihyunk Ryu, Juhyun Im, Sang Hun Kim, Si-Yong Kang, Jeong-Hee Lee, Sung-Hwan Jo, Bo-Keun Ha
Proton beam irradiation is a next-generation technique to develop mutant crop varieties. The mutagenic effects and molecular mechanisms of radiation are important multi-disciplinary research subjects. This study was conducted to investigate the types of mutations induced in the soybean genome by proton beam irradiation. In total, 22 plants, including 10 M2 plants treated with proton beam irradiation at 118 and 239 Gy, each, and two wild-type plants (Daepung) were sequenced by genotyping-by-sequencing (GBS)...
May 21, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29785604/cadmium-phytoextraction-potential-of-king-grass-pennisetum-sinese-roxb-and-responses-of-rhizosphere-bacterial-communities-to-a-cadmium-pollution-gradient
#17
Li Hu, Ru Wang, Xianglin Liu, Bo Xu, Tuanhui Xie, Yunyun Li, Mingkuang Wang, Guo Wang, Yanhui Chen
Screening for tolerant and high biomass producing plants is important for phytoextraction efforts in remediating agricultural soils contaminated by heavy metals. We carried out a greenhouse experiment involving a soil cadmium (Cd) concentration gradient (0.1, 0.5, 1, 2, 4, and 8 mg kg-1 ) to assess growth and phytoextraction capacity of king grass (Pennisetum sinese Roxb.) in soils contaminated by Cd and to explore changes in diversity and structure of rhizosphere soil bacterial communities in response to long-term Cd pollution...
May 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29785534/an-enzyme-free-homogenous-electrochemical-assay-for-sensitive-detection-of-the-plasmid-mediated-colistin-resistance-gene-mcr-1
#18
Bo Li, Zhixin Chai, Xiaohui Yan, Chunchen Liu, Bo Situ, Ye Zhang, Weilun Pan, Shihua Luo, Jianhua Liu, Lei Zheng
Antibiotic resistance associated with the mcr-1 gene of Gram-negative bacteria, which confers resistance to drugs of last resort and has the potential to spread via plasmids, is one of the most pressing issues facing global health today. Point-of-care testing for the mcr-1 gene is needed to aid in the identification of colistin resistance in the field and to control its horizontal transmission. Here, we report the successful development of an enzyme-free homogenous electrochemical strategy for sensitive detection of the antibiotic resistance gene mcr-1 using the hybridization chain reaction and mcr-1-specific toehold probe...
May 22, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29785121/association-between-angiogenesis-and-cytotoxic-signatures-in-the-tumor-microenvironment-of-gastric-cancer
#19
Yi Feng, Ying Dai, Zhihua Gong, Jia-Nan Cheng, Longhui Zhang, Chengdu Sun, Xianghua Zeng, Qingzhu Jia, Bo Zhu
Background: A suppressive immune microenvironment and pathological angiogenesis are hallmarks of gastric cancer. Theoretically, immune checkpoint inhibitors (ICIs) stimulate pre-primed neoantigen-specific T cells, and antiangiogenic agents then facilitate their infiltration into the tumor niche by promoting vascular normalization. Currently, the interconnections of these two phenotypes and their relevance to the tumor microenvironment (TME) have not been fully characterized in gastric cancer...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29785113/acupuncture-in-migraine-prophylaxis-in-czech-patients-an-open-label-randomized-controlled-trial
#20
Frantisek Musil, Jitka Pokladnikova, Zbysek Pavelek, Bo Wang, Xin Guan, Martin Valis
Background: Adjuvant acupuncture for the symptomatic treatment of migraine reduces the frequency of headaches and may be at least similarly effective to treatment with prophylactic drugs. Methods: This article describes an open-label randomized controlled clinical trial with two groups: the intervention group (n=42) and the waiting-list control group (n=44). This study occurred at the Czech-Chinese Center for Traditional Chinese Medicine at the University Hospital Hradec Kralove between October 2015 and April 2017...
2018: Neuropsychiatric Disease and Treatment
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