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https://www.readbyqxmd.com/read/28944948/use-and-modifications-of-cervical-and-upper-thoracic-laminar-screws-in-posterior-stabilization
#1
Burak Eren, Azmi Tufan, Feyza Karagöz Güzey, İlker Güleç, Abdurrahim Taş, Özgür Yusuf Aktaş, Mustafa Safi Vatansever, Ebru Doruk, Murat Yücel, Mustafa Örnek
AIM: Laminar screw technique is used to stabilize C2 and other levels when other techniques cannot be performed. MATERIAL AND METHODS: The patients underwent laminar screws at cervical and upper thoracic levels in our clinic during 5 yearswere evaluated retrospectively. RESULTS: In 25 patients, 6 to 82 years old,total 54 laminar screws were used. Most frequent diagnoses were cervical spinal stenosis and craniovertebraljunction anomalies.There were handicaps to perform other type of screwsin 19 out of 25 screws during first 4 years, and 9 out of 29 in the last year (p=0...
July 16, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28929033/baastrup-s-disease-interspinal-bursitis-and-dorsal-epidural-cysts-radiologic-evaluation-and-impact-on-treatment-options
#2
REVIEW
Jesse Hatgis, Michelle Granville, Robert E Jacobson
Baastrup's disease or "kissing spines syndrome" was first described as a cause of lumbar pain before computerized tomography (CT) and magnetic resonance imaging (MRI) scanning existed. The diagnosis was based on x-ray studies, which showed that the spinous processes, especially in the lower lumbar spine, became approximated to each other and this was a generator of positional back pain. Biomechanically, the interspinous and supraspinous ligaments that are degenerated in Baastrup's disease normally contribute significantly to sagittal alignment...
July 9, 2017: Curēus
https://www.readbyqxmd.com/read/28928494/systematic-review-and-meta-analyses-of-the-difference-between-the-spinal-level-of-the-palpated-and-imaged-iliac-crests
#3
Robert Cooperstein, Felisha Truong
OBJECTIVE: The purpose of this study was to undertake a systematic review of the literature to determine and compare, for patient sub-groups, the spinal level of the iliac crests as commonly measured through manual palpation and radiographic imaging procedures. METHODS: Relevant citations were retrieved by searching the PubMed, ICL, CINAHL, AMED, Osteopathic Research Web, OstMed, and MANTIS biomedical databases, and included articles were rated for quality. Search terms included Tuffier*, intercristal line, intercrestal line, Jacoby's line, lumbar spine, lumbar landmark, pelvic landmark, palpation, and TL (Tuffier's Line)...
August 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28915925/biomechanical-analysis-of-the-posterior-bony-column-of-the-lumbar-spine
#4
Jiukun Li, Shuai Huang, Yubo Tang, Xi Wang, Tao Pan
BACKGROUND: Each part of the rear bone structure can become an anchor point for an attachment device. The objective of this study was to evaluate the stiffness and strength of different parts of the rear lumbar bone structure by axial compression damage experiments. METHODS: Five adult male lumbar bone structures from L2 to L5 were exposed. The superior and inferior articular processes, upper and lower edges of the lamina, and upper and lower edges of the spinous process were observed and isolated and then divided into six groups (n = 10)...
September 15, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28910701/biomechanical-analysis-of-lumbar-decompression-surgery-in-relation-to-degenerative-changes-in-the-lumbar-spine-validated-finite-element-analysis
#5
Quan You Li, Ho-Joong Kim, Juhyun Son, Kyoung-Tak Kang, Bong-Soon Chang, Choon-Ki Lee, Hyun Sik Seok, Jin S Yeom
BACKGROUND: There are no studies about the biomechanical analysis of lumbar decompression surgery in relation to degenerative changes of the lumbar spine. Therefore, the purpose of this study was to compare, by using finite element (FE) analysis, the biomechanical changes of the lumbar spine in terms of annulus stress and nucleus pressure after two different kinds of lumbar decompression surgery in relation to disc degenerative changes. METHODS: The validated intact and degenerated FE models (L2-5) were used in this study...
September 6, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28910619/loss-of-hyperdirect-pathway-cortico-subthalamic-inputs-following-degeneration-of-midbrain-dopamine-neurons
#6
Hong-Yuan Chu, Eileen L McIver, Ryan F Kovaleski, Jeremy F Atherton, Mark D Bevan
The motor symptoms of Parkinson's disease (PD) are linked to abnormally correlated and coherent activity in the cortex and subthalamic nucleus (STN). However, in parkinsonian mice we found that cortico-STN transmission strength had diminished by 50%-75% through loss of axo-dendritic and axo-spinous synapses, was incapable of long-term potentiation, and less effectively patterned STN activity. Optogenetic, chemogenetic, genetic, and pharmacological interrogation suggested that downregulation of cortico-STN transmission in PD mice was triggered by increased striato-pallidal transmission, leading to disinhibition of the STN and increased activation of STN NMDA receptors...
September 13, 2017: Neuron
https://www.readbyqxmd.com/read/28894687/the-pedicles-are-not-the-densest-regions-of-the-lumbar-vertebrae-implications-for-bone-quality-assessment-and-surgical-treatment-strategy
#7
Eric A Hohn, Bryant Chu, Audrey Martin, Elizabeth Yu, Connor Telles, Jeremi Leasure, Tennyson L Lynch, Dimitriy Kondrashov
STUDY DESIGN: Cadaver study. OBJECTIVE: To determine the bone density of lumbar vertebral anatomic subregions. Bone mineral density (BMD) is a major factor in osseous fixation construct strength. The standard region for implant fixation of the spine is the pedicle; however, other regions may be more viable options with higher bone quality. METHODS: Using computed tomography images, the spine was digitally isolated by applying a filter for adult bone...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28885125/risk-factor-analysis-of-kyphotic-malalignment-after-cervical-intramedullary-tumor-resection-in-adults
#8
Satoshi Nori, Akio Iwanami, Akimasa Yasuda, Narihito Nagoshi, Nobuyuki Fujita, Tomohiro Hikata, Mitsuru Yagi, Takashi Tsuji, Kota Watanabe, Suketaka Momoshima, Morio Matsumoto, Masaya Nakamura, Ken Ishii
OBJECTIVE A number of studies have reported that surgery for cervical intramedullary tumors via the posterior approach can result in postoperative sagittal malalignment of the cervical spine; however, the risk factors remain unclear. The purpose of this study was to investigate the changes in cervical spinal alignment after surgery for cervical intramedullary tumors in adults and to elucidate the risk factors for cervical spinal sagittal misalignment. METHODS Data for the period from April 2001 to December 2011 for all adults who had undergone surgery for cervical intramedullary spinal cord tumors at a single institution were retrospectively analyzed to determine the postoperative changes in cervical spine alignment...
September 8, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28881120/a-lower-t1-slope-as-a-predictor-of-subsidence-in-anterior-cervical-discectomy-and-fusion-with-stand-alone-cages
#9
Su Hun Lee, Jun Seok Lee, Soon Ki Sung, Dong Wuk Son, Sang Weon Lee, Geun Sung Song
OBJECTIVE: Preoperative parameters including the T1 slope (T1S) and C2-C7 sagittal vertical axis (SVA) have been recognized as predictors of kyphosis after laminoplasty, which is accompanied by posterior neck muscle damage. The importance of preoperative parameters has been under-estimated in anterior cervical discectomy and fusion (ACDF) because there is no posterior neck muscle damage. We aimed to determine whether postoperative subsidence and pseudarthrosis could be predicted according to specific parameters on preoperative plain radiographs...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28867735/effects-of-ascorbyl-2-phosphate-magnesium-on-human-keratinocyte-toxicity-and-pathological-changes-by-sorafenib
#10
Kazuhiro Yamamoto, Hiroaki Shichiri, Takahiro Ishida, Kenta Kaku, Tatsuya Nishioka, Manabu Kume, Hiroo Makimoto, Tsutomu Nakagawa, Takeshi Hirano, Toshinori Bito, Chikako Nishigori, Ikuko Yano, Midori Hirai
Hand-foot skin reaction is recognized as one of the most common adverse events related to multiple tyrosine kinase inhibitors, but an effective prevention method has not been identified. The chief aim of this study was to find a mechanism-based preventive method for the skin toxicity induced by sorafenib using vitamin C derivatives. The effects of ascorbyl-2-phosphate magnesium (P-VC-Mg) on the molecular and pathological changes induced by sorafenib were investigated in human keratinocyte HaCaT cells. The cell growth inhibition and apoptotic effects of sorafenib were attenuated by P-VC-Mg...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28865018/making-of-a-synapse-recurrent-roles-of-drebrin-a-at-excitatory-synapses-throughout-life
#11
Chiye Aoki, Ang D Sherpa
Mature excitatory synapses are composed of more than 1500 proteins postsynaptically and hundreds more that operate presynaptically. Among them, drebrin is an F-actin-binding protein that increases noticeably during juvenile synaptogenesis. Electron microscopic analysis reveals that drebrin is highly enriched specifically on the postsynaptic side of excitatory synapses. Since dendritic spines are structures specialized for excitatory synaptic transmission, the function of drebrin was probed by analyzing the ultrastructural characteristics of dendritic spines of animals with genetic deletion of drebrin A (DAKO), the adult isoform of drebrin...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28859595/c6-spinous-process-fracture-in-a-young-adult
#12
Daniel J Watson, Jeffery A Dolbeer
A 21-year-old male military academy cadet developed acute posterior neck pain after performing multiple sets of overhead shoulder presses and resting the bar on his lower neck and shoulders. He presented to a direct-access physical therapy clinic. Due to the acute onset and focal nature of pain in the setting of repetitive weightlifting, the physical therapist ordered radiographs of the cervical spine, which revealed a C6 spinous process fracture. J Orthop Sports Phys Ther 2017;47(8):578. doi:10.2519/jospt...
September 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28836460/effect-of-lumbar-fasciae-on-the-stability-of-the-lower-lumbar-spine
#13
Hae Won Choi, Young Eun Kim
The biomechanical effect of tensioning the lumbar fasciae (LF) on the stability of the spine during sagittal plane motion was analysed using a validated finite element model of the normal lumbosacral spine (L4-S1). To apply the tension in the LF along the direction of the fibres, a local coordinate was allocated using dummy rigid beam elements that originated from the spinous process. Up to 10 Nm of flexion and 7.5 Nm of extension moment was applied with and without 20 N of lateral tension in the LF. A follower load of 400 N was additionally applied along the curvature of the spine...
August 24, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28816741/reflectance-confocal-microscopy-criteria-of-pigmented-squamous-cell-carcinoma-in-situ
#14
Neda Shahriari, Jane M Grant-Kels, Harold S Rabinovitz, Margaret Oliviero, Alon Scope
Pigmented squamous cell carcinoma in situ (pSCCis) is difficult to diagnose based on clinical and dermoscopic examination. Reflectance confocal microscopy (RCM) allows noninvasive differentiation between malignant and benign pigmented skin lesions. We determined the frequency of key RCM features of pSCCis and correlated the RCM criteria with the corresponding dermoscopic and histopathologic criteria. The study included 28 lesions with biopsy-proven diagnosis of pSCCis derived from 28 patients. Clinical, dermoscopic, and RCM images of these lesions were retrospectively analyzed by 3 independent observers...
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28815164/a-meta-analysis-of-cervical-laminoplasty-techniques-are-mini-plates-superior
#15
REVIEW
Ali Humadi, Tat Chao, Sulaf Dawood, Mark Tacey, Arshad Barmare, Brian Freeman
STUDY DESIGN: Meta-analysis and systematic review of literature. OBJECTIVE: In the late 1990s, spinal surgeons experimented by using maxillofacial fixation plates as an alternative to sutures, anchors, and local spinous process autografts to provide a more rigid and lasting fixation for laminoplasty. This eventually led to the advent of laminoplasty mini-plates, which are currently used. The objective is to compare laminoplasty techniques with plate and without plate with regard to functional outcome results...
June 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28809678/ultrasound-aided-vertebral-level-localization-for-lumbar-surgery
#16
Nora Baka, Sieger Leenstra, Theo van Walsum
Localization of the correct vertebral level for surgical entry during lumbar hernia surgery is not straightforward. In this paper we develop and evaluate a solution using free-hand 2D ultrasound (US) imaging in the operation room (OR). Our system exploits the difference in spinous process shapes of the vertebrae. The spinous processes are pre-operatively outlined and labeled in a lateral lumbar X-ray of the patient. Then, in the OR the spinous processes are imaged with 2D sagittal US, and are automatically segmented and registered with the X-ray shapes...
August 10, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28796755/the-effect-of-lumbar-disc-herniation-on-musculoskeletal-loadings-in-the-spinal-region-during-level-walking-and-stair-climbing
#17
Shengzheng Kuai, Zhenhua Liao, Wenyu Zhou, Xinyu Guan, Run Ji, Rui Zhang, Daiqi Guo, Weiqiang Liu
BACKGROUND People with low back pain (LBP) alter their motion patterns during level walking and stair climbing due to pain or fear. However, the alternations of load sharing during the two activities are largely unknown. The objective of this study was to investigate the effect of LBP caused by lumbar disc herniation (LDH) on the muscle activities of 17 main trunk muscle groups and the intradiscal forces acting on the five lumbar discs. MATERIAL AND METHODS Twenty-six healthy adults and seven LDH patients were recruited to perform level walking and stair climbing in the Gait Analysis Laboratory...
August 10, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28796132/optimal-point-of-insertion-and-needle-angle-in-neuraxial-blockade-using-a-midline-approach-a-study-in-computed-tomography-scans-of-adult-patients
#18
Mark Vogt, Dennis J van Gerwen, Wouter Lubbers, John J van den Dobbelsteen, Martin Hagenaars
BACKGROUND AND OBJECTIVES: Neuraxial blockade using a midline approach can be challenging. Part of this challenge lies in finding the optimal approach of the needle to its target. The present study aimed at finding (1) the optimal point of insertion of the needle between the tips of 2 adjacent spinous processes and (2) the optimal angle relative to the skin at which the needle should approach the epidural or subarachnoid space. METHODS: A computer algorithm systematically analyzed computed tomography scans of vertebral columns of a cohort of 52 patients...
September 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28794569/cortisol-homeostasis-in-the-epidermis-is-influenced-by-topical-corticosteroids-in-patients-with-atopic-dermatitis
#19
Mototsugu Fukaya
BACKGROUND: The skin produces cortisol by itself and regulates its own proliferation and differentiation. There is a possibility that topical corticosteroids (TCSs) influence the cortisol homeostasis in the skin. AIMS AND OBJECTIVES: The author described the density and distribution of cortisol and its parties in the epidermis after application of topical steroids immunohistologically. MATERIALS AND METHODS: The forearm skin was biopsied before and after 2 weeks' application of clobetasol propionate 0...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28764139/atlantooccipital-fusion-prevalence-and-its-developmental-and-clinical-correlation
#20
D K Sharma, Deepak Sharma, Vandana Sharma
INTRODUCTION: Atlantooccipital fusion or occipitalization of atlas or assimilation of atlas is a rare or uncommon abnormality recorded in anatomical, morphological and radiological studies. It is usually associated with reduction in dimensions of foramen magnum leading to acute or chronic neurovascular compression and clinical manifestations of varying severity. Though, atlantooccipital fusion is rare but it is important and significant for the physicians and surgeons for their diagnostic and therapeutic approach...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
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