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https://www.readbyqxmd.com/read/28205312/essential-roles-of-tbx3-in-embryonic-skin-development-during-epidermal-stratification
#1
Ryo Ichijo, Yui Iizuka, Hirokazu Kubo, Fumiko Toyoshima
Stepwise differentiation of epidermal cells is essential for development of stratified epithelium, but the underlying mechanisms remain unclear. Here, we show that Tbx3, a member of the T-box family of transcription factors, plays a pivotal role in this mechanism. Tbx3 is expressed in both basal and suprabasal cells in the interfollicular epidermis of mouse embryos. Epidermis-specific Tbx3 conditional knockout (cKO) embryos are small in size and display a thinner epidermis with an impaired barrier function...
February 16, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28196632/procedure-selection-and-patient-positioning-influence-spine-kinematics-during-high-velocity-low-amplitude-spinal-manipulation-applied-to-the-low-back
#2
Spencer Bell, Kevin D'Angelo, Gregory N Kawchuk, John J Triano, Samuel J Howarth
OBJECTIVES: This investigation compared indirect 3-dimensional angular kinematics (position, velocity, and acceleration) of the lumbar spine for 2 different high-velocity, low-amplitude (HVLA) spinal manipulation procedures (lumbar spinous pull or push), and altered initial patient lower limb posture. METHODS: Twenty-four participants underwent 6 HVLA procedures directed toward the presumed L4 vertebra, reflecting each combination of 2 variants of a spinal manipulation application technique (spinous pull and push) and 3 initial hip flexion angles (0°, 45°, and 90°) applied using a right lateral recumbent patient position...
February 10, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28183080/total-calcium-and-albumin-are-decreased-in-the-deeper-epidermis-of-patients-with-chronic-kidney-disease-associated-pruritus
#3
Akishi Momose, Yasuo Shiraiwa, Satoshi Narita, Tomomi Kusumi, Shoko Goto, Koichiro Sera
BACKGROUND/AIMS: In our earlier studies, we reported high concentrations of intra- and extracellular calcium ions (Ca2+) in the deeper epidermis of patients with chronic kidney disease (CKD) and associated pruritus. To determine the cause of this phenomenon, we measured total calcium (TCa) concentrations in the deeper epidermis and performed immunostaining of epidermal albumin, which binds to Ca2+. METHODS: This study included 45 patients with CKD-stage 5, which was defined as severely reduced kidney function (i...
February 10, 2017: Nephron
https://www.readbyqxmd.com/read/28180981/does-pre-operative-magnetic-resonance-imaging-of-the-lumbar-multifidus-muscle-predict-clinical-outcomes-following-lumbar-spinal-decompression-for-symptomatic-spinal-stenosis
#4
Mario G T Zotti, F Vilas Boas, T Clifton, M Piche, W W Yoon, B J C Freeman
PURPOSE: To investigate whether pre-operative magnetic resonance imaging (MRI) of the lumbar multifidus muscle (LMM) would predict clinical outcomes following lumbar spinal decompression for symptomatic spinal stenosis. METHODS: A prospective cohort of patients with symptomatic neurogenic claudication, documented spinal stenosis on pre-operative MRI underwent spinal decompression. All subjects completed standardised outcome measures (Core Outcome Measures Index (COMI), Oswestry Disability Index (ODI v2...
February 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28155840/osteitis-in-the-course-of-pyodema-gangrenosum-case-raport
#5
Andrzej Kaźmierczak-Koćwin, Robert Pieczyrak, Damian Kusz, Eugeniusz Kucharz, Marcin Kusz
We present the case of a male patient admitted to the Department of Orthopaedics and Musculoskeletal Traumatology, Medical University of Silesia (MUS) in Katowice, due to a right hindfoot abscess with calcaneal infiltration and pain in the forehead and the back, with evidence of local inflammation. The patient had a history of ulcerative colitis and sclerosing cholangitis was suspected. During the hospital stay, the patient underwent calcaneal CT, surgery (resection of an inflammatory focus) and MRI of the thoracic and lumbosacral spine, which revealed inflamed spinous processes of the Th10, Th11 and Th12 vertebrae...
November 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28153626/contralateral-interlaminar-keyhole-percutaneous-endoscopic-surgery-in-patients-with-unilateral-radiculopathy-technical-notes
#6
Jae Ha Hwang, Cheul Woong Park
OBJECTIVE: Percutaneous endoscopic surgery is increasingly used as an alternative to open microsurgery for treating lumbar spinal diseases. The purpose of this study was to determine the feasibility and efficacy of contralateral keyhole endoscopic surgery (CKES) for treating unilateral radiculopathy. METHODS: We performed percutaneous endoscopic sublaminar decompression via the contralateral interlaminar approach in 14 patients with unilateral radiculopathy. All procedures were performed under epidural anesthesia...
January 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28150052/a-histomorphometric-study-of-the-cancellous-spinal-process-bone-in-adolescent-idiopathic-scoliosis
#7
Hironori Tanabe, Yoichi Aota, Naoyuki Nakamura, Tomoyuki Saito
PURPOSE: Adolescent idiopathic scoliosis (AIS) is a three-dimensional deformity with increased risk of osteopenia of unknown etiology. This study examined the dynamic histomorphometry of AIS patients to gain insight into the underlying pathogenesis of bone metabolism changes in AIS. METHODS: Bone histomorphometry of the spinous process of the 12th thoracic vertebra was analyzed in 33 AIS patients and compared to age-matched normative data. Patients were classified into bone turnover subgroups, based on bone formation rate...
February 1, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28149341/three-dimensional-motion-analysis-of-lumbopelvic-rhythm-during-trunk-extension
#8
Michio Tojima, Naoshi Ogata, Yasuo Nakahara, Nobuhiko Haga
Hip-spine coordination, known as the lumbopelvic rhythm, can be expressed as the lumbar-hip ratio. The lumbopelvic rhythm and lumbar-hip ratio can be used to assess lower limb function. We clarified the lumbopelvic rhythm and lumbar-hip ratio during trunk extension. We established a novel set of marker positions for three-dimensional motion analysis to assess the lumbar spinal angle. The original markers were placed on both paravertebral muscle groups at the 11th thoracic spinous process level, the 10th and 12th thoracic spinous processes, and the pelvis...
April 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28144269/radioisotopic-assessment-of-bone-metabolism-of-the-operated-vertebra-after-inter-process-stabilizer-implantation-in-the-lumbar-segment-of-the-spine
#9
Maciej Radek, Andrzej Radek, Jacek Rysz, Zbigniew Maziarz, Mariusz Gadzicki, Wiesław Tryniszewski
INTRODUCTION: Lack of efficacy of pharmacotherapy and physiotherapy in spinal pain syndrome is an indication for intervertebral stabilizer implantation between the processes in the lumbar segment of the spine. MATERIAL AND METHODS: The group consisted of 32 patients qualified after radioisotopic single-photon emission computed tomography/computed tomography (SPECT/CT) examinations with assessment of bone metabolism and mineral density. For comparative purposes, the L2 vertebra was defined as normal...
February 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28137401/secondary-hyperalgesia-occurs-regardless-of-unilateral-or-bilateral-knee-osteoarthritis-involvement-in-individuals-with-mild-or-moderate-level
#10
Vanessa Martins Pereira Silva Moreira, Saulo Delfino Barboza, Juliana Borges Oliveira, Janser Moura Pereira, Valdeci Carlos Dionisio
BACKGROUND: Secondary hyperalgesia in individuals with less severe levels of knee osteoarthritis remains unclear. The objective of this study was to measure the pressure pain threshold of individuals with mild or moderate knee osteoarthritis and compare with no osteoarthritis. METHODS: Ten healthy controls and 30 individuals with mild or moderate knee osteoarthritis divided into two groups (unilateral and bilateral involvement) were included. Dermatomes in lumbar levels (L1, L2, L3, L4 and L5) and sacral level (S1 and S2), myotomes (vastus medialis, vastus lateralis, rectus femoris, adductor longus, tibialis anterior, peroneus longus, iliacus, quadratus lumborum, and popliteus muscles), and sclerotomes in lumbar levels (L1-L2, L2-L3, L3-L4, L4-L5 supraspinous ligaments), over the L5-S1 and S1-S2 sacral areas, pes anserinus bursae, and at the patellar tendon pressure pain threshold were assessed and compared between individuals with and without knee osteoarthritis...
January 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28132596/comparison-of-two-moldable-calcium-phosphate-based-bone-graft-materials-in-a-non-instrumented-canine-interspinous-implantation-model
#11
Davide Barbieri, Huipin Yuan, Ali Ismailoğlu, Joost de Bruijn
There is a continuing search for novel synthetic materials as an alternative to autologous bone grafting. Different technologies are explored to promote bone formation, which include the addition of BioGlassTM particles in calcium phosphate (CaP) based materials and the use of surface modification in the form of submicron surface topographies. In this work we aimed at comparing the bone formation in a non-instrumented canine interspinous (IS) model of moldable formulations of a submicron surface structured tricalcium phosphate/alkylene oxide (CaP/AOC) or a tricalcium phosphate/BioGlassTM/collagen (CaP/BG/C) bone graft material...
January 28, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28122400/structure-and-innervation-of-the-equine-supraspinous-and-interspinous-ligaments
#12
A Ehrle, L Ressel, E Ricci, E R Singer
Pain related to the osseous thoracolumbar spine is common in the equine athlete, with minimal information available regarding soft tissue pathology. The aims of this study were to describe the anatomy of the equine SSL and ISL (supraspinous and interspinous ligaments) in detail and to assess the innervation of the ligaments and their myofascial attachments including the thoracolumbar fascia. Ten equine thoracolumbar spines (T15-L1) were dissected to define structure and anatomy of the SSL, ISL and adjacent myofascial attachments...
January 25, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/28120442/evaluation-of-sacrospinous-hysteropexy-vs-uterosacral-suspension-for-the-treatment-of-uterine-prolapse-a-retrospective-assessment
#13
Ahmed Al-Badr, Kauser Perveen, Ghadeer Al-Shaikh
OBJECTIVE: This single-center retrospective study aimed to compare the outcomes of vaginal hysterectomy with utero-sacral suspension (VH/USS) versus sacro-spinous hysteropexy (SSHP) in the management of uterine prolapse at a tertiary care center specializing in Urogynecology. METHODS: The medical records of 50 women with stage 2 or more uterine prolapse treated with VH/USS (n = 26) or SSHP (n = 24) were assessed between January 2006 and December 2012. RESULTS: There were no significant differences between the two groups in terms of body mass index (BMI) and parity P = 0...
January 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28097249/application-of-a-3d-custom-printed-patient-specific-spinal-implant-for-c1-2-arthrodesis
#14
Kevin Phan, Alessandro Sgro, Monish M Maharaj, Paul D'Urso, Ralph J Mobbs
The study aims to describe a three-dimensional printed (3DP) posterior fixation implant used for C1/C2 fusion in a 65-year-old female. Spinal fusion remains a common intervention for a range of spinal pathologies including degenerative disc and facet disease when conservative methods are unsuccessful. However, fusion devices are not always entirely efficacious in providing the desired fixation, and surgeons rely on 'off the shelf' implants which may not provide an anatomical fit to address the particular pathology...
December 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28095493/thoracic-temporal-subtraction-three-dimensional-computed-tomography-3d-ct-screening-for-vertebral-metastases-of-primary-lung-cancers
#15
Shingo Iwano, Rintaro Ito, Hiroyasu Umakoshi, Takatoshi Karino, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa
PURPOSE: We developed an original, computer-aided diagnosis (CAD) software that subtracts the initial thoracic vertebral three-dimensional computed tomography (3D-CT) image from the follow-up 3D-CT image. The aim of this study was to investigate the efficacy of this CAD software during screening for vertebral metastases on follow-up CT images of primary lung cancer patients. MATERIALS AND METHODS: The interpretation experiment included 30 sets of follow-up CT scans in primary lung cancer patients and was performed by two readers (readers A and B), who each had 2...
2017: PloS One
https://www.readbyqxmd.com/read/28092341/unilateral-spinous-process-non-covering-hook-type-patient-specific-drill-template-for-thoracic-pedicle-screw-fixation-a-pilot-clinical-trial-and-template-classification
#16
Sang Bum Kim, Yougun Won, Hyun Jin Yoo, Lee Jae Sin, John M Rhee, Sang Wook Lee, Gi-Soo Lee
STUDY DESIGN: Prospective Clinical Pilot tudy OBJECTIVE.: To confirm the accuracy of thoracic pedicle screw placement by using the unilateral spinous non-covering hook type patient-specific drill template (PSDT) made through rapid prototyping (RP) and to analyze previously reported PSDT designs and their characteristics. SUMMARY OF BACKGROUND DATA: Pedicle screw fixation is the most common form of the posterior instrumentation of the thoracic and lumbar spine. Various techniques have been introduced to improve pedicle screw placement...
January 13, 2017: Spine
https://www.readbyqxmd.com/read/28081534/enhanced-auditory-sensitivity-to-body-vibrations-in-superior-canal-dehiscence-syndrome
#17
Krister Brantberg, Luca Verrecchia, Magnus Westin
A key feature of superior canal dehiscence (SCD) syndrome is supranormal hearing of body sounds. The aim of the present study was to quantify this phenomenon and to ascertain whether auditory sensitivity to body vibrations can distinguish SCD patients. Hearing thresholds in response to vibration at the vertex, at the spinous process of the 7th cervical vertebra, and at the medial malleolus were tested in 10 SCD patients and 10 controls. Both patients and controls had insert earphones in both ears. The insert in the test ear was blocked while masking was presented to the other ear...
January 13, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28072809/optimal-angle-of-contralateral-oblique-view-in-cervical-interlaminar-epidural-injection-depending-on-the-needle-tip-position
#18
Jun Young Park, Myung-Hwan Karm, Doo Hwan Kim, Jae-Young Lee, Hye-Joo Yun, Jeong Hun Suh
BACKGROUND: Chronic neck and upper extremity pain associated with cervical origin is common, and cervical interlaminar epidural steroid injections (CILESIs) are frequently used to manage the symptoms of cervical spinal disorders. However, CILESIs are associated with risks such as dural puncture and cord injury. OBJECTIVES: We aimed to determine the optimal needle tip visualization, in order to minimize CILESIs-induced complications. STUDY DESIGN: Retrospective observational study...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28063935/effects-of-spinal-cord-stimulation-on-motor-functions-in-children-with-cerebral-palsy
#19
I A Solopova, I A Sukhotina, D S Zhvansky, G A Ikoeva, S V Vissarionov, A G Baindurashvili, V R Edgerton, Y P Gerasimenko, T R Moshonkina
Is it possible to regulate the functional properties of abnormally developed spinal neuronal locomotor networks using transcutaneous spinal cord stimulation? This question has been studied in twenty-eight participants (∼9 yrs) with spastic cerebral palsy, and mainly Gross Motor Function Classification System for Cerebral Palsy level III. The participants were randomly assigned to two groups. The experimental group received transcutaneous spinal cord stimulation at two spinal levels (over T11 and L1 spinous processes), combined with locomotor treadmill training, whereas the participants of the control group received locomotor treadmill training only...
February 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28046606/tu-ab-bra-01-abdominal-synthetic-ct-generation-in-support-of-liver-sbrt-dose-calculation
#20
J S Bredfeldt, L Liu, M Feng, Y Cao, J Balter
PURPOSE: To demonstrate and validate a technique for generating MRI-derived synthetic CT volumes (MRCTs) in support of adaptive liver SBRT. METHODS: Under IRB approval, ten hepatocellular carcinoma patients were scanned using a single MR sequence (T1 Dixon-VIBE), yielding inherently-registered water, fat, and T1-weighted images. Air-containing voxels were identified by intensity thresholding. The envelope of the anterior vertebral bodies was segmented from the fat image by fitting a shape model to vertebral body candidate voxels, then using level sets to expand the contour outward...
June 2016: Medical Physics
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