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Sung Ae Kim, Young Wook Ryu, Jun Il Kwon, Mi Sun Choe, Jin Woong Jung, Jae We Cho
Psoriasis is a hyperproliferative inflammatory skin disease; therefore, it is highly likely that psoriatic skin lesions may transform into malignancies. However, malignant transformation is not common. We performed immunohistochemical studies using anti‑cyclin D1, anti‑cyclin E, anti‑pRb, anti‑p53, anti‑p16INK4a, and anti‑Ki‑67 antibodies in normal skin, psoriatic epidermal tissue, and squamous cell carcinoma (SCC) tissue. Furthermore, western blot analysis and immunohistochemical staining were performed to ascertain differences in cyclin D1, cyclin E, pRb, and Ki‑67 expression before and after treatment for psoriasis...
November 8, 2017: Molecular Medicine Reports
Shohreh Taghizadeh, Soraya Pirouzi, Ladan Hemmati, Fereshteh Khaledi, Aref Sadat
Objective: The purpose of this study was to investigate the position of scapula in patients with nonspecific chronic low back pain. Methods: A total of 17 participants with a history of nonspecific chronic low back pain and 17 healthy participants in the same age, sex, and weight range were enrolled in this case-control study. Lateral scapular slide test and Lennie test were used for clinical evaluation of scapular position in the frontal plane using a tape measure...
September 2017: Journal of Chiropractic Medicine
Chandraditya Chakraborty, Sudip Samadder, Anirban Roychowdhury, Anup Roy, Pradip Das, Ranajit Kumar Mandal, Susanta Roychoudhury, Chinmay Kumar Panda
In this study, importance of Wnt-β-catenin pathway in the development of uterine cervical carcinoma was evaluated. For this purpose, the profiles (expression/methylation/deletion) of β-catenin, p-β-catenin (Y654), Wnt3a, and APC were studied in disease free normal cervical epithelium (n = 9), adjacent normal cervical epithelium of primary tumors (n = 70), CIN (n = 28), CACX (n = 102) samples, and two CACX cell lines (HeLa and SiHa). Immunohistochemical analysis revealed high/medium (74-95%) expression of β-catenin/p-β-catenin (Y654) and Wnt3a and low expression (23-26%) of APC in proliferating basal-parabasal layers contrary to differentiated spinous layer in normal cervix irrespective of HPV16 infection...
October 27, 2017: Molecular and Cellular Biochemistry
Carlos A Cuellar, Aldo A Mendez, Riazul Islam, Jonathan S Calvert, Peter J Grahn, Bruce Knudsen, Tuan Pham, Kendall H Lee, Igor A Lavrov
In this study, the neuroanatomy of the swine lumbar spinal cord, particularly the spatial orientation of dorsal roots was correlated to the anatomical landmarks of the lumbar spine and to the magnitude of motor evoked potentials during epidural electrical stimulation (EES). We found that the proximity of the stimulating electrode to the dorsal roots entry zone across spinal segments was a critical factor to evoke higher peak-to-peak motor responses. Positioning the electrode close to the dorsal roots produced a significantly higher impact on motor evoked responses than rostro-caudal shift of electrode from segment to segment...
2017: Frontiers in Neuroanatomy
Wayne K Cheng, Yusuf T Akpolat, Serkan İnceoğlu, Olumide A Danisa
Pars and pedicle fractures as a result of CBT (cortical bone trajectory) during pedicle screw placement have been reported. The primary aim of the study is to compare the fracture rate between screws with modular heads to screws with standard pre-assembled tulip heads. The secondary aim of the study is to determine the potential variables that can be identified prior to instrumentation in order to predict risk of fractures. Twenty-four fresh frozen lumbar vertebrae were obtained from five different cadavers...
October 23, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Yohei Masugi, Hiroki Obata, Kimitaka Nakazawa
The purpose of this study was to investigate the effect of anode position on the spinal reflex responses evoked by transcutaneous spinal cord stimulation. Healthy males participated in two experiments. In Experiment 1 (Exp. 1, n = 3), we investigated the effect of anode position on the spinal reflex responses in multiple lower-limb muscles. Experiment 2 (Exp. 2, n = 8) focused on the effect of anode position on the spinal reflex response in the vastus medialis (VM) muscle. In each experiment, electromyographic signals were recorded in the right leg muscle(s)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Thibaut Cachon, Paul Pillard, Thierry Odent, Claude Carozzo, Eric Viguier
The pig spine is widely used as a large animal model for preclinical research in human medicine to test new spinal implants and surgical procedures. Among them, pedicle screw is one of the most common method of fixation of those implants. However, the pedicle of the porcine vertebra is not as well defined and not as large as the pedicle of the human vertebra. Therefore, the position of the screw should be adapted to the pig and not merely transposed based on the literature on humans. The purpose of this study is to determine the characteristics of the optimum implantation corridors for pedicle screws in the thoracolumbar spine of piglets of different ages using computed tomography (CT) and to determine the size and length of these corridors in pigs of different ages...
2017: PloS One
Fan Feng, Haining Tan, Xingye Li, Chong Chen, Zheng Li, Jianguo Zhang, Jianxiong Shen
BACKGROUND: Vertebrae, ribs, and spinal cord are anatomically adjacent structures, and their close relationships are clinically important for planning better corrective surgical approach. The objective is to identify the radiographic characteristics in surgical patients with congenital scoliosis (CS) and coexisting split cord malformation (SCM). METHODS: A total of 266 patients with CS and SCM underwent surgical treatment at our hospital between May 2000 and December 2015 was retrospectively identified...
October 23, 2017: BMC Musculoskeletal Disorders
Rob C Brink, Sebastiaan P J Wijdicks, Isabel N Tromp, Tom P C Schlösser, Moyo C Kruyt, Frederik J A Beek, René M Castelein
BACKGROUND CONTEXT: Radiation exposure remains a big concern in adolescent idiopathic scoliosis (AIS). Ultrasound imaging of the spine could significantly reduce or possibly even eliminate this radiation hazard. The spinous processes (SP) and transverse processes (TP), were used to measure the coronal deformity. Both landmarks provided reliable information on the severity of the curve as related to the traditional Cobb angle. However, it remained unclear which coronal ultrasound angle is the most appropriate method to measure the curve severity...
October 19, 2017: Spine Journal: Official Journal of the North American Spine Society
Agnes S Klar, Katarzyna Michalak, Sophie Böttcher-Haberzeth, Ernst Reichmann, Martin Meuli, Thomas Biedermann
AIMS AND OBJECTIVES: The use of autologous tissue-engineered skin substitutes is a promising approach to cover large skin defects in patients. Preclinical investigation is pivotal to test and improve the quality of these bio-engineered substitutes. In the skin, the epidermis, formed mainly by keratinocytes, provides the first physical barrier protecting from the environment. Proper keratinocyte differentiation and, thus, formation of a stratified epidermis is essential for this function...
October 16, 2017: Pediatric Surgery International
Salah Bellasri, Jamal Fatihi, Abderrahim Elktaibi, Abad Cherif El Asri
Vertebral hemangioma is common, benign lesion that occurs mostly in the body of vertebral bones and is mostly asymptomatic although they may occasionally extend into the posterior elements. An isolated location in the neural arch of vertebrae is extremely rare. An acute spinal cord compression by an exceptional hemangioma involving spinous process of the seventh thoracic vertebra and respecting vertebral body in a 40-year-old woman is reported. On magnetic resonance imaging of the spine, the lesion was hypointense on T1-weighted image, hyperintense on T2-weited image, and enhancing avidly, causing compression of spinal cord...
July 2017: Journal of Craniovertebral Junction and Spine
Hui Wang
INTRODUCTION: The aim of this study was to explore the predisposing factors for fracture nonunion after C1 lateral screw combined with C2 pedicle/laminar screw for type II odontoid fracture, and hope to provide references in decision making and surgical planning for spinal surgeons. METHODS: This is a retrospective study. By retrieving the medical records from January 2010 to July 2015 in our hospital, 117 type II odontoid fracture patients were reviewed. According to the occurrence of fracture union at the final follow up, patients were divided into two groups: Union group and Non-union group...
October 7, 2017: World Neurosurgery
Anna Cygańska, Aleksandra Truszczyńska-Baszak, Justyna Drzał-Grabiec, Adam Tarnowski
Young musicians often report problems with their upper limbs and spine due to their specific and asymmetric positions and actions while playing, which may contribute to overloading these structures. Diagnosing any disorders to the upper limbs or spine early may help to minimize the risk of developing any serious instrument-related health problems in the future. The aim of this study was to assess the anteroposterior (AP) spinal curvatures in children learning to play the violin. Previous studies have shown anthropomorphic differences in young adult musicians, and our study examined if these differences appeared early or late in the musician's career...
September 2017: Medical Problems of Performing Artists
Alexander Lund-Petersen, Anne Voss, Helle Laustrup
INTRODUCTION: Polymyalgia rheumatica (PMR) is an inflammatory disorder that affects the elderly. At present, evidence is limited regarding the usefulness of positron emission tomography-computed tomography (PET-CT) in the diagnosis of PMR. This study aimed to compare patient characteristics and symptoms with PET-CT findings in a Danish population of PMR patients without clinical symptoms of giant cell arteritis. METHODS: The medical records of 50 Danish PET-CT-scanned patients with PMR were reviewed...
October 2017: Danish Medical Journal
Roberto Stefini, Stefano Peron, Jaime Mandelli, Elena Bianchini, Paolo Roccucci
BACKGROUND: In recent years, spinal surgery has incorporated the many advantages of navigation techniques to facilitate the placement of pedicle screws during osteosynthesis, mainly for degenerative diseases. However, spinal intradural tumors are not clearly visible by intraoperative fluoroscopy or computed tomography scans, thereby making navigation necessary. OBJECTIVE: To evaluate the use of spinal navigation for the removal of intradural and spinal cord tumors using spinal magnetic resonance imaging (MRI) merged with intraoperative 3-dimensional (3-D) fluoro images...
August 5, 2017: Operative Neurosurgery (Hagerstown, Md.)
Martina Ulrich, Uwe Reinhold, Meritxell Falqués, Rosario Rodriguez Azeredo, Eggert Stockfleth
BACKGROUND: Actinic keratosis (AK) is a common skin disorder that can progress to invasive squamous-cell carcinoma. AK can present as clinical (visible) or sub-clinical (invisible) lesions within areas of chronic sun damage. The importance of treating sub-clinical AK is gaining support. We present a sub-analysis of a previously published Phase III, double-blind, vehicle-controlled study (NCT02289768), to assess 5-fluorouracil (5-FU) 0.5% /salicylic acid 10% treatment of sub-clinical AK lesions, based on reflectance confocal microscopy (RCM)...
September 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
Sun-Shil Shin, Won-Gyu Yoo, Duk-Hyun An, Jae-Seop Oh, Ki-Song Kim, Tae-Ho Kim, Jong-Sang Choi
BACKGROUND: Direction changes while walking are more likely to cause a hip fracture than is falling while walking in a straight line. Trunk stability is an important contributor to safe and effective walking, and arm movements influence trunk movement while walking. However, the difference in the trunk stability during semicircular turns performed by elderly women with a light bag has not been examined. OBJECTIVE: To investigate the effects of carrying a bag on trunk stability during semicircular turns in elderly women...
September 22, 2017: Journal of Back and Musculoskeletal Rehabilitation
Burak Eren, Azmi Tufan, Feyza Karagöz Güzey, İlker Güleç, Abdurrahim Taş, Özgür Yusuf Aktaş, Mustafa Safi Vatansever, Ebru Doruk, Murat Yücel, Mustafa Örnek
AIM: Laminar screw technique is used to stabilize C2 and other levels when other techniques cannot be performed. MATERIAL AND METHODS: The patients underwent laminar screws at cervical and upper thoracic levels in our clinic during 5 yearswere evaluated retrospectively. RESULTS: In 25 patients, 6 to 82 years old,total 54 laminar screws were used. Most frequent diagnoses were cervical spinal stenosis and craniovertebraljunction anomalies.There were handicaps to perform other type of screwsin 19 out of 25 screws during first 4 years, and 9 out of 29 in the last year (p=0...
July 16, 2017: Turkish Neurosurgery
Jesse Hatgis, Michelle Granville, Robert E Jacobson
Baastrup's disease or "kissing spines syndrome" was first described as a cause of lumbar pain before computerized tomography (CT) and magnetic resonance imaging (MRI) scanning existed. The diagnosis was based on x-ray studies, which showed that the spinous processes, especially in the lower lumbar spine, became approximated to each other and this was a generator of positional back pain. Biomechanically, the interspinous and supraspinous ligaments that are degenerated in Baastrup's disease normally contribute significantly to sagittal alignment...
July 9, 2017: Curēus
Robert Cooperstein, Felisha Truong
OBJECTIVE: The purpose of this study was to undertake a systematic review of the literature to determine and compare, for patient sub-groups, the spinal level of the iliac crests as commonly measured through manual palpation and radiographic imaging procedures. METHODS: Relevant citations were retrieved by searching the PubMed, ICL, CINAHL, AMED, Osteopathic Research Web, OstMed, and MANTIS biomedical databases, and included articles were rated for quality. Search terms included Tuffier*, intercristal line, intercrestal line, Jacoby's line, lumbar spine, lumbar landmark, pelvic landmark, palpation, and TL (Tuffier's Line)...
August 2017: Journal of the Canadian Chiropractic Association
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