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https://www.readbyqxmd.com/read/29752922/a-non-inferiority-randomized-controlled-trial-to-compare-transabdominal-and-transvaginal-sonography-for-eligibility-assessment-prior-to-medical-abortion
#1
Annie Fu, Caitlin E Weber, Emma Gilmore, Anne R Davis, Gregory Hirsch, Carolyn L Westhoff
OBJECTIVES: To compare transabdominal sonography (TAS) to transvaginal sonography (TVS) in medical abortion eligibility assessment; specifically to measure how often clinicians chose to order additional testing for eligibility assessment following TAS and TVS, and to look for differences by patient and clinician characteristics. Also, to compare patient acceptability between the two modalities. STUDY DESIGN: This pragmatic multi-site randomized non-inferiority trial compared TAS to TVS at 10 New York City and New Jersey health centers that provide medical abortion...
May 9, 2018: Contraception
https://www.readbyqxmd.com/read/29718011/association-of-intron-2-variable-numbers-of-an-86-bp-tandem-repeat-polymorphisms-of-interleukin-1-receptor-antagonist-gene-and-idiopathic-recurrent-spontaneous-abortion
#2
Marco Antonio Avila-Vergara, Felipe de Jesús Peraza-Garay, Noemí Meraz-Cruz, Cesar Hernandez-Guerrero, Berenice Palacios-Gonzalez, Felipe Vadillo-Ortega
Background: It has been proposed that abnormal modulation of inflammatory response is involved in the physiopathology of idiopathic recurrent spontaneous abortion (iRSA). Factors that may participate in this process include the genetic background such as carrying specific polymorphisms of genes with functional effects. Objective: The objective is to study the association between iRSA and the frequency of intron-2 variable number tandem repeat-polymorphisms of interleukin-1 receptor antagonist gene (IL1RN)...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/29701415/antiphospholipid-syndrome-and-acute-postpartum-limb-ischemia
#3
Inês Antunes, Carlos Pereira, Rui Machado, Duarte Rego, Vitor Ferreira, João Gonçalves, Gabriela Teixeira, Carlos Veiga, Daniel Mendes, Rui Almeida
INTRODUCTION: The diagnosis of Antiphospholipid syndrome (APS) implies the identification of antiphospoholipid antibodies and arterial/venous thrombosis or pregnancy loss. During pregnancy, there is an increased risk of thrombotic complications. METHODS: Present a case of acute lower limb ischemia in a patient with APS during postpartum period Materials/ Methods: review of a clinical case and available literature Results: Patient diagnosed with APS (triple antibody positive and antecedent of 3 previous abortions) underwent cesarean at 29 weeks of gestation...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29681718/therapeutic-efficacy-of-endometrial-scratching-in-repeated-controlled-ovarian-stimulation-cos-failure-cycles
#4
Leena Wadhwa, Mona Mishra
Objective: The objective of the study was (1) "to evaluate the therapeutic efficacy of endometrial scratching in repeated controlled ovarian stimulation (COS) failure cycles." And (2) "to compare differences in pregnancy outcome by endometrial scratching in early (D2-D4) and late follicular phases (D7-D9) of the same stimulation cycle." Materials and Methods: Women attending infertility clinic in a tertiary care center and who have two or more repeated COS failure cycles and planned for COS with intrauterine insemination (IUI) were included in the study which is a prospective parallel, interventional, single-blinded, randomized control study, in 1:1 allocation ratio...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29630023/timing-of-etonogestrel-implant-insertion-after-dilation-and-evacuation-a-randomized-controlled-trial
#5
Allison A Cowett, Rose Ali, Mary A Cooper, Mark Evans, Gabriel Conzuelo, Miriam Cremer
OBJECTIVE: To compare the 6-month use rate of the etonogestrel implant placed immediately after dilation and evacuation (D&E) with placement 2-4 weeks postprocedure. METHODS: This is a randomized controlled trial of women seeking abortion between 14 0/7 and 23 5/7 weeks of gestation and desiring the etonogestrel contraceptive implant at an urban family planning clinic. Participants were randomized to device insertion immediately after the D&E compared with delayed insertion in 2-4 weeks...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29625127/toxoplasma-crispr-cas9-constructs-are-functional-for-gene-disruption-in-neospora-caninum
#6
David Arranz-Solís, Javier Regidor-Cerrillo, Sebastian Lourido, Luis Miguel Ortega-Mora, Jeroen P J Saeij
Herein we describe, to our knowledge for the first time the use of the clustered regularly interspaced short palindromic repeats/ CRISPR-associated gene 9 (CRISPR/Cas9) system for genome editing of Neospora caninum, an apicomplexan parasite considered one of the main causes of abortion in cattle worldwide. By using plasmids containing the CRISPR/Cas9 components adapted to the closely related parasite Toxoplasma gondii, we successfully knocked out a green fluorescent protein (GFP) in an Nc-1 GFP-expressing strain, and efficiently disrupted the NcGRA7 gene in the Nc-Spain7 isolate by insertion of a pyrimethamine resistance cassette...
April 3, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29577943/evidence-based-adverse-outcome-pathway-approach-for-the-identification-of-bpa-as-en-endocrine-disruptor-in-relation-to-its-effect-on-the-estrous-cycle
#7
REVIEW
Catherine Viguié, Sakina Mhaouty-Kodja, René Habert, Cécile Chevrier, Cécile Michel, Elodie Pasquier
Proper cyclicity is essential to reach successful optimal fertility. In rat and mice, BPA exposure is repeatedly and reliably reported to show an adverse effect on the estrous cycle after exposures at different life stages. In humans, a possible association between modifications of menstrual cycle characteristics (e.g. length of the cycle, duration of menstrual bleeding) and sub-fecundity or spontaneous abortion has been observed. Alterations of ovarian cyclicity can therefore be definitely considered as an adverse health outcome...
March 22, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29564312/effectiveness-and-safety-of-sublingual-misoprostol-in-medical-treatment-of-the-1st-trimester-miscarriage-experience-of-off-label-use-in-korea
#8
Jung Yeon Park, Hyo Jeong Ahn, Ba Raem Yoo, Kyu Ri Hwang, Taek Sang Lee, Hye Won Jeon, Sun Min Kim, Byoung Jae Kim
Objective: This study was conducted to determine the effectiveness and safety of medical treatment with sublingual misoprostol (MS) in the 1st trimester miscarriage under the approval by Health Insurance Review and Assessment Service (HIRA) for off-label usage by the single medical center in Korea. Methods: A retrospective cohort study was performed in one institution between April 2013 and June 2016. Ninety-one patients diagnosed with miscarriage before 14 weeks of gestation and wanted to try medical treatment were included...
March 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29551429/adolescent-contraception-use-after-pregnancy-an-opportunity-for-improvement
#9
S Haider, C Stoffel, A M Dude
STUDY OBJECTIVE: To describe contraceptive method use by adolescent women in the six months following any pregnancy. DESIGN: We conducted a secondary analysis of the 2011-13 and 2013-15 cycles of the National Survey of Family Growth. SETTING: This survey is a nationally - representative population - based survey of reproductive aged women in the United States. PARTICIPANTS: The sample included respondents who had at least one pregnancy that ended both within the contraceptive calendar period and before the month of the respondent's twentieth birthday...
March 15, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29533857/qualitative-and-quantitative-analysis-of-furofuran-lignans-iridoid-glycosides-and-phenolic-acids-in-radix-dipsaci-by-uhplc-q-tof-ms-and-uhplc-pda
#10
Xinguang Sun, Yunfeng Zhang, Yinjun Yang, Jingjing Liu, Wei Zheng, Baiping Ma, Baolin Guo
Radix Dipsaci (RD), the dried root of Dipsacus asper, is used in traditional Chinese medicine as a remedy for bone fractures, traumatic hematoma, threatened abortion, and uterine bleeding. A novel ultra high-performance liquid chromatography coupled with quadrupole-time-of-flight tanderm mass spectrometry (UHPLC-Q-TOF/MS) approach was performed to rapidly characterize the chemical constituents of RD. Consequently, 21 compounds, including 12 iridoid glycosides (IGs), 4 furofuran lignans (FLs), and 5 phenolic acids (PAs) were discovered and identified from RD...
March 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29518409/abiei-binds-cooperatively-to-the-type-iv-abie-toxin-antitoxin-operator-via-a-positively-charged-surface-and-causes-dna-bending-and-negative-autoregulation
#11
Hannah G Hampton, Simon A Jackson, Robert D Fagerlund, Anne I M Vogel, Ron L Dy, Tim R Blower, Peter C Fineran
Bacteria resist phage infection using multiple strategies, including CRISPR-Cas and abortive infection (Abi) systems. Abi systems provide population-level protection from phage predation, via "altruistic" cell suicide. It has recently been shown that some Abi systems function via a toxin-antitoxin mechanism, such as the widespread AbiE family. The Streptococcus agalactiae AbiE system consists of a bicistronic operon encoding the AbiEi antitoxin and AbiEii toxin, which function as a Type IV toxin-antitoxin system...
April 13, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29501973/safety-and-efficacy-of-the-bumped-kinase-inhibitor-bki-1553-in-pregnant-sheep-experimentally-infected-with-neospora-caninum-tachyzoites
#12
Roberto Sánchez-Sánchez, Ignacio Ferre, Michela Re, Patricia Vázquez, Luis Miguel Ferrer, Javier Blanco-Murcia, Javier Regidor-Cerrillo, Manuel Pizarro Díaz, Marta González-Huecas, Enrique Tabanera, Paula García-Lunar, Julio Benavides, Pablo Castaño, Andrew Hemphill, Matthew A Hulverson, Grant R Whitman, Kasey L Rivas, Ryan Choi, Kayode K Ojo, Lynn K Barrett, Wesley C Van Voorhis, Luis Miguel Ortega-Mora
Neospora caninum is one of the main causes of abortion in cattle, and recent studies have highlighted its relevance as an abortifacient in small ruminants. Vaccines or drugs for the control of neosporosis are lacking. Bumped kinase inhibitors (BKIs), which are ATP-competitive inhibitors of calcium dependent protein kinase 1 (CDPK1), were shown to be highly efficacious against several apicomplexan parasites in vitro and in laboratory animal models. We here present the pharmacokinetics, safety and efficacy of BKI-1553 in pregnant ewes and foetuses using a pregnant sheep model of N...
April 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29497328/managing-cluster-headache-with-sphenopalatine-ganglion-stimulation-a-review
#13
REVIEW
Denys Fontaine, Serena Santucci, Michel Lanteri-Minet
Cluster headache (CH) is a primary headache and considered as one of the worst pains known to man. The sphenopalatine ganglion (SPG) plays a pivotal role in cranial autonomic symptoms associated with pain. Lesioning procedures involving the SPG and experimental acute SPG stimulation have shown some degree of efficacy with regard to CH. A neuromodulation device, chronically implanted in the pterygopalatine fossa, has been specifically designed for acute on-demand SPG stimulation. In a pilot placebo-controlled study in 28 patients suffering from refractory chronic CH, alleviation of pain was achieved in 67...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29456564/role-of-granulocyte-colony-stimulating-factor-in-human-reproduction
#14
REVIEW
Maryam Eftekhar, Elham Naghshineh, Parisa Khani
As new research reveals, granulocyte colony-stimulating factor (G-CSF) plays an effective role in pregnancy success, considering that it not only affects the embryo implantation and ovarian function but also it promotes endometrial thickening and improves the pathophysiology of endometriosis, which all fundamentally lead to reducing pregnancy loss. In this review, we focus on the role of G-CSF in human reproduction. We summarized its role in ovulation, luteinized unruptured follicle syndrome, poor responders, improving repeated in vitro fertilization failure, endometrial receptivity and treatment of thin endometrium, and recurrent spontaneous abortion...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29445929/prevalence-of-leptospira-serogroup-specific-antibodies-in-cattle-associated-with-reproductive-problems-in-endemic-states-of-india
#15
Vinayagamurthy Balamurugan, Anusha Alamuri, K Bharathkumar, Sharanagouda Siddanagouda Patil, Gurrappa Naidu Govindaraj, Mohandoss Nagalingam, Paramanandham Krishnamoorthy, Habibur Rahman, Bibek Ranjan Shome
In this study, the seroprevalence and distribution of Leptospira in dairy cattle in endemic states of India were investigated in association with reproductive problems of the cattle. A total of 373 cattle serum samples from 45 farms in Maharashtra, Gujarat, Andhra Pradesh, Telangana, Karnataka, Tamil Nadu, Punjab, Haryana, Chhattisgarh, Sikkim and Uttarakhand states were collected from animals with a history of reproductive disorders like abortion, repeat breeding, anoestrus and endometritis, and also from apparently healthy animals...
February 14, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29436536/quantum-dots-for-a-high-throughput-pfu-polymerase-based-multi-round-polymerase-chain-reaction-pcr
#16
Fuming Sang, Zhizhou Zhang, Lin Yuan, Deli Liu
Multi-round PCR is an important technique for obtaining enough target DNA from rare DNA resources, and is commonly used in many fields including forensic science, ancient DNA analysis and cancer research. However, multi-round PCR is often aborted, largely due to the accumulation of non-specific amplification during repeated amplifications. Here, we developed a Pfu polymerase based multi-round PCR technique assisted by quantum dots (QDs). Different PCR assays, DNA polymerases (Pfu and Taq), DNA sizes and GC amounts were compared in this study...
February 26, 2018: Analyst
https://www.readbyqxmd.com/read/29403308/the-relationship-between-the-pd-1-pd-l1-pathway-and-dna-mismatch-repair-in-cervical-cancer-and-its-clinical-significance
#17
Yang-Chun Feng, Wen-Li Ji, Na Yue, Yan-Chun Huang, Xiu-Min Ma
Background: According to recent clinical observations, deficient DNA mismatch repair (dMMR) is capable of improving antitumor effects of the PD-1/PD-L1 pathway, suggesting that dMMR may act as a prognostic indicator of PD-1/PD-L1 antibody drugs. In this study, we examined the dMMR and PD-1/PD-L1 expression, as well as explored the correlation of dMMR status with PD-1/PD-L1 expression in cervical cancer patients, in order to optimize cervical cancer patient selection for PD-1/PD-L1 antibody drug treatment, which is helpful to avoid adverse effects and keep costs manageable...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29391674/comparison-of-mifepristone-followed-by-misoprostol-with-misoprostol-alone-for-treatment-of-early-pregnancy-failure-a-randomized-double-blind-placebo-controlled-trial
#18
Priya Sinha, Amita Suneja, Kiran Guleria, Richa Aggarwal, Neelam B Vaid
Objective: To compare the efficacy and safety of mifepristone followed by misoprostol with misoprostol alone in the management of early pregnancy failure (EPF). Study Design: A randomized double-blind placebo-controlled clinical trial. Methods: Ninety-two women with EPF ≤12 weeks were recruited and randomly allocated to receive either mifepristone 200 mg ( n  = 46) or placebo ( n  = 46). Forty-eight hours later, patients in both the groups were given 800 µg misoprostol per-vaginum...
February 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29366856/contemporary-trends-and-survival-outcomes-after-aborted-radical-prostatectomy-in-lymph-node-metastatic-prostate-cancer-patients
#19
Marco Bandini, Felix Preisser, Sebastiano Nazzani, Michele Marchioni, Zhe Tian, Nicola Fossati, Giorgio Gandaglia, Andrea Gallina, Firas Abdollah, Shahrokh F Shariat, Francesco Montorsi, Fred Saad, Derya Tilki, Alberto Briganti, Pierre I Karakiewicz
BACKGROUND: Aborted radical prostatectomy (aRP) in lymph node (LN) metastatic (pN1) prostate cancer (PCa) patients showed worse survival in European patients. Contemporary rates of aRP are unknown in North America. OBJECTIVE: To examine the rate of aRP and its effect on cancer-specific mortality (CSM) in contemporary North American patients. DESIGN, SETTING, AND PARTICIPANTS: Within the Surveillance Epidemiology and End Results database (2004-2014), we identified 3719 pN1 PCa patients...
January 20, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29327156/effectiveness-of-celecoxib-for-pain-relief-and-antipyresis-in-second-trimester-medical-abortions-with-misoprostol-a-randomized-controlled-trial
#20
Hatern Tintara, Peangpailin Voradithi, Thanapan Choobun
PURPOSE: To evaluate the effectiveness of celecoxib for pain relief and antipyresis during second trimester abortion using sublingual misoprostol. METHODS: Fifty-six pregnant women of gestational age 14-24 weeks were randomly assigned in a double-blind randomized controlled trial to receive 400 mg of celecoxib or placebo just before sublingual administration of misoprostol 400 µg every 6 h. Pain and body temperature (BT) were assessed every 1 h until the abortion or 24 h after the first dose of misoprostol...
March 2018: Archives of Gynecology and Obstetrics
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