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gastrectomy D1 D2 meta analysis

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https://www.readbyqxmd.com/read/26550311/surgical-interventions-for-gastric-cancer-a-review-of-systematic-reviews
#1
Weiling He, Jian Tu, Zijun Huo, Yuhuang Li, Jintao Peng, Zhenwen Qiu, Dandong Luo, Zunfu Ke, Xinlin Chen
AIM: To evaluate methodological quality and the extent of concordance among meta-analysis and/or systematic reviews on surgical interventions for gastric cancer (GC). METHODS: A comprehensive search of PubMed, Medline, EMBASE, the Cochrane library and the DARE database was conducted to identify the reviews comparing different surgical interventions for GC prior to April 2014. After applying included criteria, available data were summarized and appraised by the Oxman and Guyatt scale...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/24628950/gastrichip-d2-resection-and-hyperthermic-intraperitoneal-chemotherapy-in-locally-advanced-gastric-carcinoma-a-randomized-and-multicenter-phase-iii-study
#2
RANDOMIZED CONTROLLED TRIAL
Olivier Glehen, Guillaume Passot, Laurent Villeneuve, Delphine Vaudoyer, Sylvie Bin-Dorel, Gilles Boschetti, Eric Piaton, Alfredo Garofalo
BACKGROUND: In Europe, gastric cancer remains diagnosed at advanced stage (serosal and/or lymph node involvement). Despite curative management combining perioperative systemic chemotherapy and gastrectomy with D1-D2 lymph node dissection, 5-year survival rates of T3 and/or N + patients remain under 30%. More than 50% of recurrences are peritoneal and/or locoregional. The use of adjuvant hyperthermic intraperitoneal chemotherapy that eliminates free cancer cells that can be released into peritoneal cavity during the gastrectomy and prevents peritoneal carcinomatosis recurrences, was extensively evaluated by several randomized trials conducted in Asia...
March 14, 2014: BMC Cancer
https://www.readbyqxmd.com/read/23512524/survival-and-recurrence-free-benefits-with-different-lymphadenectomy-for-resectable-gastric-cancer-a-meta-analysis
#3
Lei Jiang, Ke-Hu Yang, Quan-Lin Guan, Peng Zhao, Yan Chen, Jin-Hui Tian
BACKGROUND: The objective of the present meta-analysis was to estimate the magnitude of survival and recurrence free benefits from different lymphadenectomy in patients with resectable gastric cancer. METHODS: A comprehensive search was performed for original studies published from their inception to 2012. Two reviewers independently assessed search results, methodological quality, and data extraction of included studies. Results regarding the overall survival (OS) and recurrence free survival (RFS) in the meta-analysis were expressed as hazard ratios (HR) with 95% confidence intervals (CI)...
June 2013: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/22258947/withdrawn-extended-versus-limited-lymph-nodes-dissection-technique-for-adenocarcinoma-of-the-stomach
#4
REVIEW
Peter McCulloch, Marcelo Eidi Nita, Hussain Kazi, Joaquin J Gama-Rodrigues
BACKGROUND: Surgeons disagree about the merits and risks of radical lymph node clearance during gastrectomy for cancer. OBJECTIVES: To evaluate survival and peri-operative mortality after limited or extended lymph node removal during gastrectomy for cancer. SEARCH METHODS: We searched MEDLINE, EMBASE, CancerLit, LILACS, Central Medical Journal Japanese Database and the Cochrane register, references from relevant articles and conference proceedings...
2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/21394009/meta-analysis-of-d1-versus-d2-gastrectomy-for-gastric-adenocarcinoma
#5
REVIEW
Muhammed Ashraf Memon, Manjunath S Subramanya, Shahjahan Khan, Md Belal Hossain, Emma Osland, Breda Memon
OBJECTIVES: To conduct a meta-analysis of randomized controlled trials evaluating the efficacy and drawbacks of limited (D1) versus extended lymphadenectomy (D2) for proven gastric adenocarcinoma. METHODS: A search of Cochrane, Medline, PubMed, Embase, Science Citation Index and Current Contents electronic databases identified randomized controlled trials published in the English language between 1980 and 2008 comparing the outcomes of D1 versus D2 gastrectomy for gastric adenocarcinoma...
May 2011: Annals of Surgery
https://www.readbyqxmd.com/read/19030751/impact-of-extended-lymphadenectomy-on-morbidity-mortality-recurrence-and-5-year-survival-after-gastrectomy-for-cancer-meta-analysis-of-randomized-clinical-trials
#6
REVIEW
Suzana Angélica Silva Lustosa, Humberto Saconato, Alvaro Nagib Atallah, Gaspar de Jesus Lopes Filho, Delcio Matos
PURPOSE: To compare morbidity, mortality, recurrence and 5-year survival between D1 and D2 or D3 for treatment of gastric cancer. METHODS: Systematic review and meta-analysis of RCTs. Metaview in RevMan 4.2.8 for analysis; statistical heterogeneity by Cochran's Q test (P<0.1) and I(2) test (P>50%). Estimates of effect were calculated using random effects model. RESULTS: D2 or D3 was associated with higher in-hospital mortality, with RR = 2...
November 2008: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/18722583/an-evidence-based-medicine-review-of-lymphadenectomy-extent-for-gastric-cancer
#7
REVIEW
Sun Hu Yang, You Cheng Zhang, Ke Hu Yang, You Ping Li, Xiao Dong He, Jin Hui Tian, Ting Hong Lv, Ying Hua Hui, Neel Sharma
BACKGROUND: Several studies in the literature have investigated the possible role of the extent of lymphadenectomy in gastric cancer treatment failure. The current study attempted to determine the effectiveness and safety of lymphadenectomy with gastrectomy for the treatment of gastric cancer. METHODS: Randomized controlled trials (RCTs) were identified by means of MEDLINE, EMBASE, Cochrane Controlled Trials Register databases, and Chinese Biomedical Database, as well as by selecting references from relevant articles...
February 2009: American Journal of Surgery
https://www.readbyqxmd.com/read/17851781/-clinical-values-of-extended-lymph-node-dissection-for-gastric-cancer-a-meta-analysis-for-d1-versus-d2-gastrectomy
#8
Xue-fei Wang, Yi-hong Sun, De-ji Liang, Cong Wang, Yong Fang, Tian-shu Liu, Xin-yu Qin
OBJECTIVE: To evaluate the survival, complication and postoperative mortality after D(1) or D(2) lymph node dissection for gastric cancer. METHODS: All the randomized clinical trials about nodal dissection for gastric cancer published within the last 20 years were collected. Quality assessment was done on each trial and relevant data were extracted from qualified trials. Meta-analysis was performed with the use of RevMan 4.2 (Cochrane) for statistic analysis. RESULTS: Three hundred and ninety-four trials were yielded at the initial search...
September 2007: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/15635680/gastrectomy-with-extended-lymphadenectomy-for-primary-treatment-of-gastric-cancer
#9
REVIEW
P McCulloch, M Eidi Niita, H Kazi, J J Gama-Rodrigues
BACKGROUND: The appropriate extent of lymph node clearance during gastrectomy for cancer remains controversial. METHODS: Medline, Embase, the Cochrane register and other databases were searched for studies reporting node dissection technique, 5 year survival and mortality after gastrectomy. Comparisons with systematic bias in treatment allocation and patients who received perioperative chemotherapy were excluded. Meta-analysis was performed separately for randomized and non-randomized comparisons...
January 2005: British Journal of Surgery
https://www.readbyqxmd.com/read/15495024/extended-versus-limited-lymph-nodes-dissection-technique-for-adenocarcinoma-of-the-stomach
#10
REVIEW
P McCulloch, M E Nita, H Kazi, J Gama-Rodrigues
BACKGROUND: Surgeons disagree about the merits and risks of radical lymph node clearance during gastrectomy for cancer. OBJECTIVES: To evaluate survival and peri-operative mortality after limited or extended lymph node removal during gastrectomy for cancer. SEARCH STRATEGY: We searched MEDLINE, EMBASE, CancerLit, LILACS, Central Medical Journal Japanese Database and the Cochrane register, references from relevant articles and conference proceedings...
2004: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/14583942/extended-versus-limited-lymph-nodes-dissection-technique-for-adenocarcinoma-of-the-stomach
#11
REVIEW
P McCulloch, M E Nita, H Kazi, J Gama-Rodrigues
BACKGROUND: Surgeons disagree about the merits and risks of radical lymph node clearance during gastrectomy for cancer. OBJECTIVES: To evaluate survival and peri-operative mortality after limited or extended lymph node removal during gastrectomy for cancer. SEARCH STRATEGY: We searched MEDLINE, EMBASE, CancerLit, LILACS, Central Medical Journal Japanese Database and the Cochrane register, references from relevant articles and conference proceedings...
2003: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/12587378/-chemoradiotherapy-in-the-adjuvant-treatment-of-gastric-adenocarcinomas-real-progress
#12
REVIEW
L Mineur, F Lacaine, M Ychou, J F Bosset, A Daban
Frequency of local and distant failures after gastrectomy has led to extended lymph nodes dissection to obtain a better locoregional control. However, five year survival rates were not significantly different between patients undergoing D2 and D1 lymphadenectomy, and higher morbidity and post operative deaths were reported in large randomised trials (respectively 25% vs 48% and 4 vs 13%). Additionally, several metanalysis failed to demonstrate a significant survival advantage with adjuvant chemotherapy. The results of the first trial demonstrating one advantage to adjuvant post-operative chemoradiotherapy should modify the standard care...
November 2002: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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