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gastrectomy D1 vs D2

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https://www.readbyqxmd.com/read/27336885/comparison-of-laparoscopy-assisted-and-open-radical-gastrectomy-for-advanced-gastric-cancer-a-retrospective-study-in-a-single-minimally-invasive-surgery-center
#1
Yingxue Hao, Peiwu Yu, Feng Qian, Yongliang Zhao, Yan Shi, Bo Tang, Dongzhu Zeng, Chao Zhang
Laparoscopy-assisted gastrectomy (LAG) has gained international acceptance for the treatment of early gastric cancer (EGC). However, the use of laparoscopic surgery in the management of advanced gastric cancer (AGC) has not attained widespread acceptance. This retrospective large-scale patient study in a single center for minimally invasive surgery assessed the feasibility and safety of LAG for T2 and T3 stage AGC. A total of 628 patients underwent LAG and 579 patients underwent open gastrectomy (OG) from Jan 2004 to Dec 2011...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27266816/extended-lymphadenectomy-in-elderly-and-or-highly-co-morbid-gastric-cancer-patients-a-retrospective-multicenter-study
#2
S Rausei, L Ruspi, F Rosa, P Morgagni, D Marrelli, A Cossu, F C M Cananzi, R Lomonaco, A Coniglio, A Biondi, C Cipollari, L Graziosi, U Fumagalli, F Casella, P Bertoli, A di Leo, S Alfieri, G Vittimberga, F Roviello, E Orsenigo, V Quagliuolo, S Montemurro, G Baiocchi, R Persiani, M Bencivenga, A Donini, R Rosati, A Sansonetti, L Ansaloni, A Zanoni, F Galli, G Dionigi
BACKGROUND: Gastrectomy with extended lymphadenectomy is considered the gold standard treatment for advanced gastric cancer, with no age- or comorbidity-related limitations. We evaluated the safety and efficacy of curative gastrectomy with extended nodal dissection, verifying survival in elderly and highly co-morbid patients. METHODS: In a retrospective multicenter study, we examined 1322 non-metastatic gastric-cancer patients that underwent curative gastrectomy with D2 versus D1 lymphadenectomy from January 2000 to December 2009...
June 1, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26996496/optimal-extent-of-lymphadenectomy-for-gastric-adenocarcinoma-a-7-institution-study-of-the-u-s-gastric-cancer-collaborative
#3
Reese W Randle, Douglas S Swords, Edward A Levine, Nora F Fino, Malcolm H Squires, George Poultsides, Ryan C Fields, Mark Bloomston, Sharon M Weber, Timothy M Pawlik, Linda X Jin, Gaya Spolverato, Carl Schmidt, David Worhunsky, Clifford S Cho, Shishir K Maithel, Konstantinos I Votanopoulos
BACKGROUND AND OBJECTIVES: The optimal extent of lymphadenectomy in the treatment of gastric adenocarcinoma is debated. We compared gastrectomy outcomes following limited (D1) or extended (D2) lymphadenectomy. METHODS: Using the multi-institutional US Gastric Cancer Collaborative database, we reviewed the morbidity, mortality, recurrence, and overall survival (OS) of patients receiving D1 or D2 lymphadenectomies. RESULTS: Between 2000 and 2012, 266 and 461 patients received a D1 and D2 lymphadenectomy, respectively...
June 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26564243/long-term-survival-in-patients-with-gastroesophageal-junction-cancer-treated-with-preoperative-therapy-do-thoracic-and-abdominal-approaches-differ
#4
COMPARATIVE STUDY
Peter J Kneuertz, Wayne L Hofstetter, Yi-Ju Chiang, Prajnan Das, Mariela Blum, Elena Elimova, Paul Mansfield, Jaffer Ajani, Brian Badgwell
BACKGROUND: The optimal surgical approach for gastroesophageal junction (GEJ) cancer treated with preoperative therapy remains controversial. We compared the outcomes of patients who underwent either esophagectomy or gastrectomy and identified variables associated with overall survival (OS). METHODS: We reviewed records of patients with Siewert types II and III GEJ adenocarcinoma who were treated with preoperative therapy followed by resection from 1995 to 2013...
February 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26550311/surgical-interventions-for-gastric-cancer-a-review-of-systematic-reviews
#5
Weiling He, Jian Tu, Zijun Huo, Yuhuang Li, Jintao Peng, Zhenwen Qiu, Dandong Luo, Zunfu Ke, Xinlin Chen
AIM: To evaluate methodological quality and the extent of concordance among meta-analysis and/or systematic reviews on surgical interventions for gastric cancer (GC). METHODS: A comprehensive search of PubMed, Medline, EMBASE, the Cochrane library and the DARE database was conducted to identify the reviews comparing different surgical interventions for GC prior to April 2014. After applying included criteria, available data were summarized and appraised by the Oxman and Guyatt scale...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26074682/short-term-and-long-term-risk-factors-in-gastric-cancer
#6
COMPARATIVE STUDY
Giuseppe Verlato, Daniele Marrelli, Simone Accordini, Maria Bencivenga, Alberto Di Leo, Alberto Marchet, Roberto Petrioli, Giacomo Zoppini, Michele Muggeo, Franco Roviello, Giovanni de Manzoni
While in chronic diseases, such as diabetes, mortality rates slowly increases with age, in oncological series mortality usually changes dramatically during the follow-up, often in an unpredictable pattern. For instance, in gastric cancer mortality peaks in the first two years of follow-up and declines thereafter. Also several risk factors, such as TNM stage, largely affect mortality in the first years after surgery, while afterward their effect tends to fade. Temporal trends in mortality were compared between a gastric cancer series and a cohort of type 2 diabetic patients...
June 7, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25899981/does-a-minimum-number-of-16-retrieved-nodes-affect-survival-in-curatively-resected-gastric-cancer
#7
MULTICENTER STUDY
A Biondi, D D'Ugo, F C M Cananzi, V Papa, A Borasi, F Sicoli, M Degiuli, G Doglietto, R Persiani
BACKGROUND: According to the TNM classification, the analysis of 16 or more lymph nodes is required for the appropriate staging of gastric cancer. The aim of this study was to evaluate whether this number of resected lymph nodes also affects survival. METHODS: This was a multicenter retrospective study based on an analysis of 992 patients with gastric adenocarcinoma who underwent curative resection between January 1980 and December 2009. Patients were classified according to the number of resected lymph nodes (<16 and ≥16 lymph nodes), the anatomical extent of lymph node dissection (D2 vs...
June 2015: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25707350/impact-of-super-extended-lymphadenectomy-on-relapse-in-advanced-gastric-cancer
#8
G de Manzoni, G Verlato, M Bencivenga, D Marrelli, A Di Leo, S Giacopuzzi, C Cipollari, F Roviello
BACKGROUND: In gastric cancer the incidence of loco-regional recurrences decreases when lymphadenectomy is expanded from D1 to D2. The present study aimed at evaluating whether the pattern of recurrence in advanced gastric cancer (AGC) is further modified when lymphadenectomy is expanded from D2 to D3. METHODS: 568 patients undergoing curative gastrectomy for AGC (274 D2 and 294 D3) were considered; none of them received preoperative chemotherapy. MantelHaenszel test of homogeneity was used to verify whether the relation between extension of lymphadenectomy and recurrence varied as a function of each risk factor considered...
April 2015: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/24151383/characteristics-and-prognosis-of-gastric-cancer-in-patients-aged-%C3%A2-70-years
#9
Yue-Xiang Liang, Jing-Yu Deng, Han-Han Guo, Xue-Wei Ding, Xiao-Na Wang, Bao-Gui Wang, Li Zhang, Han Liang
AIM: To elucidate the prognostic value of age for gastric cancer and identify the optimal treatment for elderly gastric cancer patients. METHODS: We enrolled 920 patients with gastric cancer who underwent gastrectomy between January 2003 and December 2007 in our center. Patients were categorized into three groups: younger group (age < 50 years), middle-aged group (50-69 years), and elderly group (≥ 70 years). Clinicopathological features were compared among the three groups and potential prognostic factors were analyzed...
October 21, 2013: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/23867588/overview-of-adjuvant-and-neoadjuvant-therapy-for-resectable-gastric-cancer-in-the-east
#10
REVIEW
Kazumasa Fujitani
This review presents the current status of adjuvant and neoadjuvant treatment options for primary resectable gastric cancer in the East, with updated data from recent studies. Marked disparities between the East and the West in standard surgical procedures (D2 vs. D1/0 lymphadenectomy) and their outcomes result in significant geographical variation in preferred adjuvant treatments. Currently, oral fluoropyrimidine-based postoperative adjuvant chemotherapy, 1 year of S-1 chemotherapy, or capecitabine plus oxaliplatin for 6 months are the standards of care after curative resection with D2 lymphadenectomy for stage II/III gastric cancer in the East, though there is still some room for improvement...
2013: Digestive Surgery
https://www.readbyqxmd.com/read/23793806/short-term-outcome-of-total-laparoscopic-distal-gastrectomy-for-overweight-and-obese-patients-with-gastric-cancer
#11
Motokazu Sugimoto, Takahiro Kinoshita, Hidehito Shibasaki, Yuichiro Kato, Naoto Gotohda, Shinichiro Takahashi, Masaru Konishi
BACKGROUND: Laparoscopic distal gastrectomy for gastric cancer has been firmly established in recent decades but still is a difficult procedure, especially for obese patients, as with open surgery. This study aimed to evaluate the perioperative outcome of total laparoscopic distal gastrectomy (TLDG) for early gastric cancer patients with a body mass index (BMI) exceeding 25 kg/m(2) and to consider countermeasures to this. METHODS: Perioperative outcomes were compared between 42 patients with a BMI exceeding 25 kg/m(2) [overweight or obese group (OWG)] and 174 patients with a BMI lower than 25 kg/m(2) [normal or underweight group (NWG)] who underwent TLDG between September 2010 and December 2012...
November 2013: Surgical Endoscopy
https://www.readbyqxmd.com/read/23290108/-impact-of-surgical-modalities-for-gastric-cancer-on-operational-trauma
#12
COMPARATIVE STUDY
Hui Wu, Ping-ping Xu, Yu-long He, Jian-bo Xu, Shi-rong Cai, Xin-hua Zhang, Liang Wang, Dong-jie Yang, Wen-hua Zhan
OBJECTIVE: To evaluate the impact of surgical modality for gastric cancer on operational trauma. METHODS: A total of 1499 cases of gastric cancer undergoing surgical procedures were divided into the groups of radical resection (RR, n = 1344) and palliative resection group (NRR, n = 155) according to their surgical modalities. And they were further divided into sub-groups according to the profiles of gastrectomy, extent of lymphadenectomy and multi organic resection...
October 16, 2012: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/23211117/comparison-of-short-term-surgical-outcomes-between-laparoscopic-and-open-total-gastrectomy-for-gastric-carcinoma-case-control-study-using-propensity-score-matching-method
#13
COMPARATIVE STUDY
Oh Jeong, Mi Ran Jung, Gwang Yong Kim, Han Soo Kim, Seong Yeop Ryu, Young Kyu Park
BACKGROUND: To evaluate the technical feasibility and safety of laparoscopic total gastrectomy (LTG) for gastric carcinoma, this study compared short-term surgical outcomes between LTG and open total gastrectomy (OTG) using the propensity score matching method. STUDY DESIGN: After generating propensity scores given the covariates of age, sex, body mass index, comorbidity, American Society of Anesthesiologists (ASA) score, operators, and tumor stage, 122 patients with LTG were matched to 122 OTG patients using the nearest available score matching...
February 2013: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/23129382/selecting-the-best-treatment-for-an-individual-patient
#14
REVIEW
Alessandro Bittoni, Luca Faloppi, Riccardo Giampieri, Stefano Cascinu
Several factors concur in determining outcome for locally advanced gastric cancer patients. Shockingly, geographic origin of the patient seems to play a major role. In Eastern countries, the high level of surgery that can be expected grants a high percentage of success in a strategy that employs surgery as immediate treatment followed by adjuvant chemotherapy, mainly based on oral fluoropyrimidines (S-1 or Capecitabine), with satisfactory results. In Western countries, the expertise of the surgeon maintains its role as predictor of high likelihood of cure...
2012: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/22777320/impact-of-histopathology-on-the-outcome-of-d1-d2-gastrectomies-with-r0-resection
#15
Adam Uslu, Hasan Bati, Hakan Postaci, Ahmet Nart, Nukhet Eliyatkin, Halit Yetis, Baris Corumlu, Ahmet Aykas, Baha Zengel
AIMS: The primary objective of this study was to clarify the influence of histotype on the outcome of D1/D2 gastrectomized patients with pathologically proven R0 resection. The secondary objective was to demonstrate overall survival (OS), disease-free survival (DFS), and locoregional recurrence rates following standard curative surgery. PATIENTS AND METHODS: All patients had either pure signet-ring cell carcinoma (SRCC)/poorly differentiated adenocarcinoma (PDC) or moderately differentiated adenocarcinoma (MDC) of the stomach, preoperative radiologic evidence of locoregional disease, and no history of neoadjuvant therapy...
2012: Digestion
https://www.readbyqxmd.com/read/22340539/predictive-factors-improving-survival-after-gastric-and-hepatic-surgical-treatment-in-gastric-cancer-patients-with-synchronous-liver-metastases
#16
Jing Liu, Jing-Hui Li, Ru-Jun Zhai, Bo Wei, Ming-Zhe Shao, Lin Chen
BACKGROUND: The prognosis for patients with gastric cancer and synchronous liver metastases is very poor. However, a standard therapeutic strategy has not been well established. The clinical benefit and prognostic factors after hepatic surgical treatment for liver metastases from gastric cancer remain controversial. METHODS: Records of 105 patients who underwent gastrectomy regardless of hepatic surgical treatment for gastric cancer with synchronous liver-only metastases in our center between 1995 and 2010 were retrospectively reviewed...
January 2012: Chinese Medical Journal
https://www.readbyqxmd.com/read/22205454/-neutrophil-lymphocyte-ratio-as-a-prognostic-factor-in-gastric-cancer
#17
Jin-ping Ma, Zhi Wang, Jian-wei Lin, Kai-ming Wu, Jian-hui Chen, Chuang-qi Chen, Shi-rong Cai, Yu-long He, Wen-hua Zhan
OBJECTIVE: To explore whether neutrophil-lymphocyte ratio (NLR) is an effective prognostic marker in gastric cancer. METHODS: Clinical data of 775 patients with gastric cancer in the First Affiliated Hospital of Sun Yat-sen University from 1994 to 2006 were analyzed retrospectively. According to preoperative NLR, the patients were divided into the low NLR group (NLR≤3.79, n=652) and the high NLR group (NLR>3.79, n=123). The 5-year survival rates of two groups of different TNM stage, different surgical intervention were separately analyzed...
December 2011: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/22127080/d2-lymph-node-dissection-improves-staging-in-patients-with-gastric-adenocarcinoma
#18
COMPARATIVE STUDY
Krishna Putchakayala, L Andrew Difronzo
Debate continues over the recommended extent of routine lymphadenectomy for gastric cancer. Although evidence of improved locoregional control with extended dissection accumulates, understaging and stage migration continue to confound the issue. Our objective was to determine whether D2 lymph node dissection improves staging compared with D1 in patients with gastric adenocarcinoma. We performed a retrospective study of 79 consecutive patients who underwent resection of gastric adenocarcinoma at a single institution...
October 2011: American Surgeon
https://www.readbyqxmd.com/read/21576595/robotic-gastrectomy-as-an-oncologically-sound-alternative-to-laparoscopic-resections-for-the-treatment-of-early-stage-gastric-cancers
#19
COMPARATIVE STUDY
Yanghee Woo, Woo Jin Hyung, Kyung-Ho Pak, Kazuki Inaba, Kazutaka Obama, Seung Ho Choi, Sung Hoon Noh
OBJECTIVE: To evaluate the comparative safety and efficacy of robotic vs laparoscopic gastrectomy for early-stage gastric cancer. DESIGN: Retrospective analysis. SETTING: Tertiary hospital. PATIENTS: Eight hundred twenty-seven patients with gastric cancer. INTERVENTIONS: Between July 2005 and April 2009, 827 patients with gastric cancer underwent 236 robotic and 591 laparoscopic radical gastrectomies with curative intent...
September 2011: Archives of Surgery
https://www.readbyqxmd.com/read/21186409/-efficacy-observation-after-pylorus-preserving-gastrectomy-for-early-gastric-cancer
#20
Xiang Hu, Liang Cao, Yi Yu, Da-yu Tian
OBJECTIVE: To evaluate the outcomes after pylorus-preserving gastrectomy (PPG) for early gastric cancer(EGC). METHODS: Clinicopathologic data of 52 patients with EGC undergoing PPG between August 1995 and December 2005 were analyzed retrospectively. A total of 159 patients of EGC who underwent distal gastrectomy with lymph node dissection(control group) were compared with those who received PPG. RESULTS: The lymph node metastasis rate of EGC was 9...
December 2010: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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