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Mineral bone disease

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https://www.readbyqxmd.com/read/29929041/bone-and-plasma-citrate-is-reduced-in-osteoporosis
#1
Hongdong Chen, Yeyang Wang, Huaiqian Dai, Xinggui Tian, Zhong-Kai Cui, Zhenguo Chen, Le Hu, Qiancheng Song, Anling Liu, Zhiyong Zhang, Guozhi Xiao, Jian Yang, Yu Jiang, Xiaochun Bai
High concentration of citrate exists in bone of humans and all osteo-vertebrates, and citrate incorporation imparts important biomechanical and other functional properties to bone. However, which cells are responsible for citrate production in bone remains unclear and whether the citrate component changes with bone loss during osteoporosis is also not known. Here, we show that the citrate content is markedly reduced in the bone of mice or rats with age-related, ovariectomy-induced or retinoic acid-induced bone loss...
June 18, 2018: Bone
https://www.readbyqxmd.com/read/29926949/peri-implant-health
#2
Mauricio G Araujo, Jan Lindhe
OBJECTIVE: The aim is to define clinical and histologic characteristics of peri-implant tissues in health and describe the mucosa-implant interface. IMPORTANCE: An understanding of the characteristics of healthy peri-implant tissues facilitates the recognition of disease (i.e., departure from health). FINDINGS: The healthy peri-implant mucosa is, at the microscopic level, comprised of a core of connective tissue covered by either a keratinized (masticatory mucosa) or non-keratinized epithelium (lining mucosa)...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926494/peri-implant-health
#3
Mauricio G Araujo, Jan Lindhe
OBJECTIVE: The aim is to define clinical and histologic characteristics of peri-implant tissues in health and describe the mucosa-implant interface. IMPORTANCE: An understanding of the characteristics of healthy peri-implant tissues facilitates the recognition of disease (i.e., departure from health). FINDINGS: The healthy peri-implant mucosa is, at the microscopic level, comprised of a core of connective tissue covered by either a keratinized (masticatory mucosa) or non-keratinized epithelium (lining mucosa)...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29925892/raman-spectroscopy-detects-changes-in-bone-mineral-quality-and-collagen-cross-linkage-in-staphylococcus-infected-human-bone
#4
Mohamed Khalid, Tanujjal Bora, Ahmed Al Ghaithi, Sharanjit Thukral, Joydeep Dutta
Diagnosis of osteomyelitis presents a formidable challenge. Lack of pathognomonic clinical sign(s) and diagnostic tests that can diagnose osteomyelitis at an early stage contribute to this difficulty. If the diagnosis is not made early, the disease becomes very difficult to eradicate and can lead to limb threatening and potentially life-threatening complications. Staphylococcus aureus is the most common organism causing osteomyelitis. Raman Spectroscopy provides information about molecular vibration that could potentially be harnessed as a spectral signature for cellular changes in specific pathologic conditions...
June 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29925739/-treatment-of-mandibular-fracture-associated-infectious-pseudarthrosis-accompanied-by-osteomyelitis-in-a-peritoneal-dialysis-patient
#5
Soichi Hirashima, Akihiko Miyawaki, Kotaro Oho, Yawaka Shitozawa, Motohiro Arai, Norihiko Furuta, Ryoichi Oya
Peritoneal dialysis can be performed at home, and the transfer of solutes in the blood and other body fluids is slow compared to hemodialysis, reducing the load on the circulatory organs and lessening the frequency of hospital visits. We encountered a male patient in his 70s on peritoneal dialysis for end-stage renal failure who developed obsolete mandibular fracture-associated pseudarthrosis accompanied by osteomyelitis, which was treated with noninvasive reduction and fixation using circumferential wiring after the resolution of inflammation...
2018: Journal of UOEH
https://www.readbyqxmd.com/read/29924424/identification-of-an-epigenetic-signature-of-osteoporosis-in-blood-dna-of-post-menopausal-women
#6
David Cheishvili, Surabhi Parashar, Niaz Mahmood, Ani Arakelian, Richard Kremer, David Goltzman, Moshe Szyf, Shafaat A Rabbani
Osteoporosis is one of the most common age-related progressive bone diseases in elderly people. Approximately one in three women and one in five men are predisposed to developing OP. In postmenopausal women a reduction in bone mineral density (BMD) leads to an increased risk of fractures. In the current study we delineated the DNA methylation signatures in whole blood samples of postmenopausal osteoporotic women. We obtained whole blood DNA from 22 normal women and 22 postmenopausal osteoporotic women (51-89 years) from the Canadian Multicenter Osteoporosis Study (CaMos) cohort...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29923023/biodistribution-of-strontium-and-barium-in-the-developing-and-mature-skeleton-of-rats
#7
Arash Panahifar, L Dean Chapman, Lynn Weber, Nazanin Samadi, David M L Cooper
Bone acts as a reservoir for many trace elements. Understanding the extent and pattern of elemental accumulation in the skeleton is important from diagnostic, therapeutic, and toxicological perspectives. Some elements are simply adsorbed to bone surfaces by electric force and are buried under bone mineral, while others can replace calcium atoms in the hydroxyapatite structure. In this article, we investigated the extent and pattern of skeletal uptake of barium and strontium in two different age groups, growing, and skeletally mature, in healthy rats...
June 19, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29921207/role-of-bisphosphonates-in-vascular-calcification-and-bone-metabolism-a-clinical-summary
#8
Pradeep Dayanand, Harigopal Sandhyavenu, Sandeep Dayanand, Jasmin Martinez, Janani Rangaswami
Vascular calcification is known to be a strong risk factor for cardiovascular adverse events and mortality. Atherosclerosis, diabetes, aging, abnormal bone mineral homeostasis and high uremic milieu such as chronic kidney disease are major factors that contribute to the progression of vascular calcification. Several mechanisms such as the osteoblastic transition of vascular smooth muscle cells in response to oxidative stress have shed light on the active nature of vascular calcification, which was once thought to be a passive process...
June 18, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29916126/the-effect-of-%C3%AE-aminopropionitrile-on-skeletal-micromorphology-and-osteogenesis
#9
Yu Shen, Dian Jing, Jin Hao, Ge Tang, Pu Yang, Zhihe Zhao
Collagen cross-linking, as a form of collagen post-translational modification, plays a crucial role in maintaining bone mechanical properties as well as in regulating cell biological functions. Shifts in cross-links profile are found apparently correlated to kinds of skeletal pathology and diseases, whereas little is known about the relationship between collagen cross-links and osteogenesis. Here, we hypothesized that the inhibition of collagen cross-links could impair skeletal microstructure and inhibit osteogenesis...
June 18, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29914840/altered-body-composition-sarcopenia-frailty-and-their-clinico-biological-correlates-in-parkinson-s-disease
#10
Ai Huey Tan, Yin Cheng Hew, Shen-Yang Lim, Norlisah Mohd Ramli, Shahrul Bahyah Kamaruzzaman, Maw Pin Tan, Mathis Grossmann, Ban Hong Ang, Jiun Yan Tan, Mohamad Addin Azhan A Manap, Tun Khong Tay, Siang Lyn Tan, Ru Peng New, Farhana Fadzli, Eng Jui Yee, Foong Ming Moy, Sanjiv Mahadeva, Anthony E Lang
INTRODUCTION: Low body weight in Parkinson's disease (PD) is poorly understood despite the associated risks of malnutrition, fractures, and death. Sarcopenia (loss of muscle bulk and strength) and frailty are geriatric syndromes that are likewise associated with adverse health outcomes, yet have received scant attention in PD. We studied body composition, sarcopenia, frailty, and their clinico-biological correlates in PD. METHODS: 93 patients and 78 spousal/sibling controls underwent comprehensive assessment of diet, clinical status, muscle strength/performance, frailty, body composition (using dual-energy X-ray absorptiometry), and serum levels of neurogastrointestinal hormones and inflammatory markers...
June 13, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29914510/early-use-of-alendronate-as-a-protective-factor-against-the-development-of-glucocorticoid-induced-bone-loss-in-childhood-onset-rheumatic-diseases-a-cross-sectional-study
#11
Yuzaburo Inoue, Kanako Mitsunaga, Takeshi Yamamoto, Koki Chiba, Fumiya Yamaide, Taiji Nakano, Yoshinori Morita, Akiko Yamaide, Shuichi Suzuki, Takayasu Arima, Ken-Ichi Yamaguchi, Minako Tomiita, Naoki Shimojo, Yoichi Kohno
BACKGROUND: Bisphosphonates are recommended for use as first-line therapy for the prevention and treatment of glucocorticoid-induced osteoporosis in adults. However, the appropriate usage of bisphosphonates for the prevention or treatment of glucocorticoid-induced osteoporosis in children remains unclear. METHODS: We performed a cross-sectional study to clarify the factors associated with the development of glucocorticoid-induced bone loss and osteoporosis in patients with childhood-onset rheumatic disease and to investigate the impact of the early use of alendronate...
June 18, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29913256/the-effect-of-glucocorticoids-on-bone-mineral-density-in-patients-with-rheumatoid-arthritis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
Anne-Birgitte Blavnsfeldt, Annette de Thurah, Malissa Dawn Thomsen, Simon Tarp, Bente Langdahl, Ellen-Margrethe Hauge
PURPOSE: The role of glucocorticoids in the treatment of rheumatoid arthritis (RA) is widely debated. Impairment of bone formation may be counter-balanced by reduced systemic inflammation. This review aims to assess the effect of prednisolone/prednisone on bone mineral density (BMD) in patients with RA analyzed in randomized, controlled trials. METHODS: We performed a systematic literature search and identified randomized, double-blinded placebo-controlled studies including patients with RA and using prednisolone or prednisone as the intervention...
June 15, 2018: Bone
https://www.readbyqxmd.com/read/29912988/severe-secondary-hyperparathyroidism-in-patients-on-haemodialysis-is-associated-with-a-high-initial-serum-parathyroid-hormone-and-beta-crosslaps-level-results-from-an-incident-cohort
#13
Guillaume Jean, Marie Hélène Lafage-Proust, Jean Claude Souberbielle, Sylvain Lechevallier, Patrik Deleaval, Christie Lorriaux, Jean Marc Hurot, Brice Mayor, Manolie Mehdi, Charles Chazot
BACKGROUND: Secondary hyperparathyroidism (SHPT) is a frequent complication of renal disease and most commonly occurs in patients on haemodialysis (HD) with metabolic, vascular, endocrine, and bone complications. The aim of this study was to analyze the evolution of mineral metabolism parameters during the first 36 months of HD treatment and identify the initial factors associated with severe SHPT. METHODS: Serum parathyroid hormone (PTH), calcium and phosphate levels were measured monthly; bone-specific alkaline phosphatase (b-ALP) and beta-CrossLaps (CTX) were measured biannually...
2018: PloS One
https://www.readbyqxmd.com/read/29911458/retrieval-of-a-periodontally-compromised-tooth-by-allogeneic-grafting-of-mesenchymal-stem-cells-from-dental-pulp-a-case-report
#14
Beatriz Hernández-Monjaraz, Edelmiro Santiago-Osorio, Edgar Ledesma-Martínez, Andrés Alcauter-Zavala, Víctor Manuel Mendoza-Núñez
Objective To report a case of successful allogeneic grafting of mesenchymal dental pulp stem cells (DPSCs) as preliminary findings in a patient with periodontal disease enrolled into clinical trial ISRCTN12831118. Methods Mesenchymal stem cells from the dental pulp of a deciduous tooth from a 7-year-old donor were separated from the pulp chamber and processed via enzymatic digestion and centrifugation. DPSCs were passaged and cultured on a 35 × 13 mm culture dish in minimum essential medium-alpha, without supplementation...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29911038/lean-mass-and-disease-activity-are-the-best-predictors-of-bone-mineral-loss-in-the-premenopausal-women-with-rheumatoid-arthritis
#15
Meha Sharma, Urmila Dhakad, Anupam Wakhlu, Danveer Bhadu, Deep Dutta, Siddharth K Das
Background and Objectives: Factors determining bone mineral (BM) loss in rheumatoid arthritis (RA) are not well known. This study aimed to determine the occurrence and predictors of BM loss in the young premenopausal women with RA. Methods: Ninety-six females with RA and 90 matched controls underwent clinical, biochemical, BM density (BMD), and body composition assessments. RA disease activity was assessed using disease activity score-28 (DAS-28) and hand X-ray...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910605/role-of-etelcalcetide-in-the-management-of-secondary-hyperparathyroidism-in-hemodialysis-patients-a-review-on-current-data-and-place-in-therapy
#16
REVIEW
Claudia Friedl, Emanuel Zitt
Secondary hyperparathyroidism (sHPT) is a frequently occurring severe complication of advanced kidney disease. Its clinical consequences include extraskeletal vascular and valvular calcifications, changes in bone metabolism resulting in renal osteodystrophy, and an increased risk of cardiovascular morbidity and mortality. Calcimimetics are a cornerstone of parathyroid hormone (PTH)-lowering therapy, as confirmed by the recently updated 2017 Kidney Disease: Improving Global Outcomes chronic kidney disease - mineral and bone disorder clinical practice guidelines...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29909470/risk-of-fracture-and-low-bone-mineral-density-in-adults-with-inflammatory-bowel-diseases-a-systematic-literature-review-with-meta-analysis
#17
REVIEW
P Szafors, H Che, T Barnetche, J Morel, C Gaujoux-Viala, B Combe, C Lukas
Inflammatory bowel diseases (IBDs) are associated with a decreased bone mineral density, but the impact on fractures is unknown. In our study, global risk of fracture is increased for patients with IBDs versus controls. This result will help to determine the appropriate assessment with early screening and management of osteoporosis. Inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis (UC), are associated with a decreased bone mineral density (BMD). However, the impact on fracture risk is unknown and data are contradictory across studies...
June 16, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29907149/changes-in-bone-mineral-density-after-total-parathyroidectomy-without-autotransplantation-in-the-end-stage-renal-disease-patients-with-secondary-hyperparathyroidism
#18
Li Fang, Jining Wu, Jing Luo, Ping Wen, Mingxia Xiong, Jinlong Cao, Xiaolan Chen, Junwei Yang
BACKGROUND: The patients with secondary hyperparathyroidism (SHPT) usually had reduced bone mineral density, which might lead to a substantial increase in osteoporosis, fracture and mortality. Although surgical intervention is effective in reducing parathyroid hormone (PTH) levels in suitable candidates refractory to medical therapy, the effect of surgery on bone mass changes still requires further evaluation. Thus, the aim of this study was to evaluate the characteristics of BMD changes after total parathyroidectomy (PTX) without autotransplantation and its associated factors...
June 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29905968/skeletal-consequences-of-nephropathic-cystinosis
#19
Pablo Florenzano, Carlos Ferreira, Galina Nesterova, Mary Scott Ramnitz, Sri Harsha Tella, Luis Fernandez de Castro, Sydney M Brown, Adom Whitaker, Renata C Pereira, Dorothy Bulas, Rachel I Gafni, Isidro B Salusky, William A Gahl, Michael T Collins
Nephropathic cystinosis is a rare lysosomal storage disorder. Patients present in the first year of life with renal Fanconi syndrome that evolves to progressive chronic kidney disease (CKD). Despite the multiple risk factors for bone disease, the frequency and severity of skeletal disorders in nephropathic cystinosis have not been described. We performed systematic bone and mineral evaluations of subjects with cystinosis seen at the NIH (N = 30), including history and physical examination, serum and urine biochemistries, DXA, vertebral fracture assessment, skeletal radiographs, and renal ultrasound...
June 15, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29904824/patient-satisfaction-and-efficacy-of-switching-from-weekly-bisphosphonates-to-monthly-minodronate-for-treatment-and-prevention-of-glucocorticoid-induced-osteoporosis-in-japanese-patients-with-systemic-rheumatic-diseases-a-randomized-clinical-trial
#20
Shin-Ya Tamechika, Kaneshige Sasaki, Yoshihito Hayami, Shin-Ichiro Ohmura, Shinji Maeda, Shiho Iwagaitsu, Taio Naniwa
The randomized, clinical trial demonstrated that switching to monthly minodronate from weekly alendronate and risedronate provides greater increases in patients' satisfaction and bone mineral density and more substantial decreases in a bone resorption marker than continuing weekly alendronate and risedronate in patients with systemic rheumatic diseases on glucocorticoid therapy. PURPOSE: Osteoporosis and associated fractures are major concerns for patients with systemic rheumatic diseases on long-term glucocorticoid therapy...
June 13, 2018: Archives of Osteoporosis
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