Michael Haffner, Azra Ajkunic, Erolcan Sayar, Martine Roudier, Radhika Patel, Ilsa Coleman, Navonil Sarkar, Brian Hanratty, Mohamed Adil, Jimmy Zhao, Samir Zaidi, Larry True, Jamie Sperger, Heather Cheng, Evan Yu, Robert Montgomery, Jessica Hawley, Gavin Ha, John Lee, Stephanie Harmon, Eva Corey, Joshua Lang, Charles Sawyers, Colm Morrissey, Michael Schweizer, Roman Gulati, Peter Nelson
Therapeutic approaches targeting proteins on the surface of cancer cells have emerged as an important strategy for precision oncology. To fully capitalize on the potential impact of drugs targeting surface proteins, detailed knowledge about the expression patterns of the target proteins in tumor tissues is required. In castration-resistant prostate cancer (CRPC), agents targeting prostate-specific membrane antigen (PSMA) have demonstrated clinical activity. However, PSMA expression is lost in a significant number of CRPC tumors, and the identification of additional cell surface targets is necessary in order to develop new therapeutic approaches...
December 19, 2023: Research Square