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https://www.readbyqxmd.com/read/29901071/curcumin-inhibits-cell-proliferation-and-motility-via-suppression-of-trop2-in-bladder-cancer-cells
#1
Lianhua Zhang, Guoliang Yang, Ruiyun Zhang, Liang Dong, Haige Chen, Juanjie Bo, Wei Xue, Yiran Huang
Bladder cancer (BC) has become a serious health prob-lem and represents the second most commonly diagnosed urological tumor. Curcumin is a principal active natural component of turmeric and has long been used in Asia as a traditional herbal medicine. Curcumin suppresses cell growth in various types of cancer, including BC, by regulating numerous molecular signaling pathways. The human trophoblast cell surface antigen 2 (Trop2) belongs to the tumor-associated calcium signal transducer gene family. Trop2 has been described as a cancer driver and is deregulated in various types of cancer...
May 30, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29897391/a-case-series-of-five-patients-with-pure-or-mixed-gestational-epithelioid-trophoblastic-tumors-and-a-literature-review-on-mixed-tumors
#2
Ka Yu Tse, Keith Wan Hang Chiu, Karen Kar Loen Chan, Mandy Man Yee Chu, Siew Fei Ngu, Annie Nga Yin Cheung, Hextan Yuen Sheung Ngan, Philip Pun Ching Ip
Objectives: To review the clinicopathologic features of five patients with epithelioid trophoblastic tumor (ETT). Methods: Characteristics of patients diagnosed with ETT in 2000 to 2012 were reviewed. Results: Among 190 patients with gestational trophoblastic neoplasia (GTN), two had pure ETT and three had mixed ETT and choriocarcinoma. The median age was 32.5 years. All the patients had localized disease in the uterus. One patient with pure ETT had a recurrence in the ureter 6 years after the initial treatment...
June 11, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29884426/pulmonary-arteriovenous-malformation-after-metastatic-gestational-trophoblastic-tumor
#3
Christine Costa, Jérôme Massardier, Delphine Gamondes, Vincent Cottin
No abstract text is available yet for this article.
June 5, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29849983/ectopic-expression-of-human-dppa2-gene-in-escc-cell-line-using-retroviral-system
#4
Maryam Khaleghizadeh, Mohammad Mahdi Forghanifard, Abolfazl Rad, Moein Farshchian, Zahra Hejazi, Mehran Gholamin, Bahram Memar, Mohammad Reza Abbaszadegan
Background: Cancer/Testis Antigens (CTAs) are a sub-group of tumor-associated antigens which are expressed normally in germ line cells and trophoblast, and aberrantly in a variety of malignancies. One of the most important CTAs is Developmental Pluripotency Associated-2(DPPA2) with unknown biological function. Considering the importance of DPPA2 in developmental events and cancer, preparing a suitable platform to analyze DPPA2 roles in the cells seems to be necessary. Methods: In this study, the coding sequence of DPPA2 gene was amplified and cloned into the retroviral expression vector to produce recombinant retrovirus...
April 2018: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/29794762/successful-treatment-of-multisite-hemorrhage-by-several-methods-in-brain-metastasis-of-choriocarcinoma-a-case-report
#5
Zhen Ren, Li Yu, Mengnv Xie, Yiyi Liang, Fang Zhu, Rui Huang, Zhibang Zhang, Chun Fu
RATIONALE: Brain metastasis of choriocarcinoma is a highly malignant gestational trophoblastic neoplasia (GTN) and has a notoriously poor prognosis. Hemorrhagic choriocarcinoma lesions may lead to life-threatening conditions also. Treatment of brain metastases of choriocarcinoma with hemorrhage in multiple sites is very difficult in clinical practices. A patient has been successfully treated in our hospital, which provides as clinical references for this difficulty in treating brain metastases of choriocarcinoma with hemorrhage in multiple sites...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29782306/urticarial-lesions-in-a-pregnant-woman
#6
Sergio Santos-Alarcón, Cesar Benavente-Villegas, Isabel García-Briz, Magdalena Moneva-Léniz, Celia Sanchis-Sánchez, Almudena Mateu-Puchades
Dear Editor, Gestational pemphigoid (GP) is a rare autoimmune bullous dermatosis in pregnancy. GP usually occurs during the second or third month of pregnancy. It clinically manifests as the development of either early-onset urticarial lesions or late-onset subepidermal blisters that may linger for weeks or even months. Herein we report the case of a 45-year-old woman with the distinctive clinical onset of GP. A forty-five-year-old woman, gravida I, para 0, at 27 weeks gestation, was referred for evaluation to our Department with an extensive pruritic eruption that had developed over the previous 7 days...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29780773/clinical-characteristics-and-outcomes-of-placental-site-trophoblastic-tumor-experience-of-single-institution-in-korea
#7
Hye-Joo Lee, Wonkyo Shin, Yun Jeong Jang, Chel Hun Choi, Jeong-Won Lee, Duk-Soo Bae, Byoung-Gie Kim
Objective: Placental site trophoblastic tumor (PSTT) is the rarest form of gestational trophoblastic disease (GTD) and the optimum management is still controversial. In this study, we analyzed the clinical features, treatment, and outcomes of 6 consecutive patients with PSTT treated in our institution. Methods: The electronic medical record database of Samsung Medical Center was screened to identify patients with PSTT from 1994 to 2017. Medical records for the details of each patient's clinical features and treatment were extracted and reviewed...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29768178/trained-memory-of-human-uterine-nk-cells-enhances-their-function-in-subsequent-pregnancies
#8
Moriya Gamliel, Debra Goldman-Wohl, Batya Isaacson, Chamutal Gur, Natan Stein, Rachel Yamin, Michael Berger, Myriam Grunewald, Eli Keshet, Yoach Rais, Chamutal Bornstein, Eyal David, Adam Jelinski, Iris Eisenberg, Caryn Greenfield, Arbel Ben-David, Tal Imbar, Ronit Gilad, Ronit Haimov-Kochman, David Mankuta, Matan Elami-Suzin, Ido Amit, Jacob H Hanna, Simcha Yagel, Ofer Mandelboim
Natural killer cells (NKs) are abundant in the human decidua, regulating trophoblast invasion and angiogenesis. Several diseases of poor placental development are associated with first pregnancies, so we thus looked to characterize differences in decidual NKs (dNKs) in first versus repeated pregnancies. We discovered a population found in repeated pregnancies, which has a unique transcriptome and epigenetic signature, and is characterized by high expression of the receptors NKG2C and LILRB1. We named these cells Pregnancy Trained decidual NK cells (PTdNKs)...
May 15, 2018: Immunity
https://www.readbyqxmd.com/read/29762819/mir-134-inhibits-infiltration-of-trophoblast-cells-in-placenta-of-patients-with-preeclampsia-by-decreasing-itgb1-expression
#9
A-X Zou, B Chen, Q-X Li, Y-C Liang
OBJECTIVE: Preeclampsia (PE) is an idiopathic disorder of pregnancy. The specific regulatory mechanisms of microRNAs (miRs) in the placenta of PE patients have not yet been completely revealed. This study mainly explored the mechanism of miR-134 in preeclampsia. PATIENTS AND METHODS: Real-time PCR and Western blot were used to detect the expression of miR-134 and ITGB1 in the placenta of patients with preeclampsia and normal pregnant women. Dual luciferase reporter assay was performed to detect luciferase activity in miR-134 and NC groups, respectively...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29757875/surgery-and-platinum-etoposide-based-chemotherapy-for-the-treatment-of-epithelioid-trophoblastic-tumor
#10
Janelle Sobecki-Rausch, Abigail Winder, Kruti P Maniar, Anna V Hoekstra, Emily Berry, Karen Novak, John R Lurain
OBJECTIVE: Epithelioid trophoblastic tumor (ETT) is a rare variant of gestational trophoblastic neoplasia that develops from chorionic-type intermediate trophoblast, simulates carcinoma, presents years after a pregnancy event, is associated with low or normal human chorionic gonadotropin levels, and is relatively resistant to chemotherapy. Our aim was to identify the role of surgery in combination with platinum/etoposide-based chemotherapy in the management of both localized and metastatic ETT...
May 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29736307/a-novel-5t4-targeting-antibody-drug-conjugate-h6-dm4-exhibits-potent-therapeutic-efficacy-in-gastrointestinal-tumor-xenograft-models
#11
Ruixue Wang, Qinhuai Lai, Liangze Tang, Yiran Tao, Yuqin Yao, Yu Liu, Ying Lu, Chaoyong Shen, Ran Lu, Chuanwen Fan, Ruirui Zhang, Yuxi Wang, Lin Yu, Tinghan Yang, Yangping Wu, Yujia Peng, Xian Wei, Yuyin Fu, Weirong Lai, Lantu Gou, Jinliang Yang
5T4, also named as trophoblast glycoprotein, is often upregulated in some cancer cells. Here, we demonstrated that 5T4 was highly expressed in gastric, colorectal, and pancreatic cancer, associated with significantly poor prognosis of gastrointestinal (GI) cancer patients. To search for new targeting drugs for GI cancer, we developed a novel anti-5T4 monoclonal antibody with high affinity and robust internalization ability and conjugated it to the potent microtubule inhibitor DM4 to produce conjugate H6-DM4...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29736154/decreased-il-33-production-contributes-to-trophoblast-cell-dysfunction-in-pregnancies-with-preeclampsia
#12
Hong Chen, Xiaobo Zhou, Ting-Li Han, Philip N Baker, Hongbo Qi, Hua Zhang
Preeclampsia (PE) is a life-threatening pregnancy complication which is related to aggradation of risk regarding fetal and maternal morbidity and mortality. Dysregulation of systemic inflammatory response and dysfunction of trophoblast cells have been proposed to be involved in the development and progression of PE. Some studies have demonstrated that interleukin-33 (IL-33) is an immunomodulatory cytokine that is associated with the immune regulation of tumor cells. However, little is known whether IL-33 and its receptor ST2/IL-1 R4 could regulate trophoblast cells, which are associated with the pathogenesis of PE...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29735973/baicalein-enhances-migration-and-invasion-of-extravillous-trophoblasts-via-activation-of-the-nf-%C3%AE%C2%BAb-pathway
#13
Jia Liu, Shan-Shan Lv, Zi-Yi Fu, Li-Li Hou
BACKGROUND Baicalein, one of the major flavonoids in the plant [i]Scutellaria baicalensis[/i], can regulate the invasive ability of cancer cells. The invasion of trophoblasts is similar to the invasion of tumor cells into host tissues. The appropriate invasion of trophoblast cells into the endometrium is an important factor for successful embryo implantation. In this research, we investigated the effect of baicalein on the invasion and migration of trophoblast cells and its possible molecular mechanism. MATERIAL AND METHODS We treated HTR-8/SVneo cells with different concentrations (0, 0...
May 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29723118/protective-effects-of-interferon-tau-against-lipopolysaccharide-induced-embryo-implantation-failure-in-pregnant-mice
#14
Kangfeng Jiang, Jing Yang, Yu Chen, Shuai Guo, Gan Zhao, Haichong Wu, Ganzhen Deng
Interferon-tau (IFN-τ), a novel type I interferon, is produced by trophoblast cells in ruminants. Previous studies have confirmed that IFN-τ could induce immunological tolerance in humans and other species. However, there are few reports on whether IFN-τ has a protective effect on embryo implantation failure caused by excessive inflammation at the maternal-fetal interface. In our study, a mouse model of lipopolysaccharide (LPS)-induced implantation failure was successfully established, and we investigated the protective effects of IFN-τ...
May 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29718107/the-intervention-effect-of-aspirin-on-a-lipopolysaccharide-induced-preeclampsia-like-mouse-model-by-inhibiting-the-nf-%C3%AE%C2%BAb-pathway
#15
Guanlin Li, Liyang Ma, Li Lin, Yan-Ling Wang, Huixia Yang
Preeclampsia is a severe pregnancy-related disorder, and patients usually present with high circulating inflammatory factor production as well as excessive activation of the nuclear factor-κB (NF-κB) pathway. Administration of aspirin (ASP) is effective for the prevention of preeclampsia, we proposed that ASP might affect placental function by regulating the NF-κB pathway. Systemic lipopolysaccharide (LPS) (20 μg/kg) was used to induce preeclampsia-like pregnant mouse model and low-dose ASP (15.2 mg/kg) were further treated...
April 27, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29703038/dedifferentiated-endometrioid-adenocarcinoma-with-trophoblastic-components-and-elevated-serum-alfa-fetoprotein-a-case-report-and-literature-review
#16
REVIEW
He Cai, Rong Zhou, Wanying Liang, Jianliu Wang
RATIONALE: Dedifferentiated endometrioid adenocarcinoma (DEAC) consisted of a combination of undifferentiated and differentiated carcinoma is more aggressive than other conventional endometrioid adenocarcinomas. PATIENT CONCERNS: A 33-year-old woman with atypical vaginal bleeding was refereed to our hospital. She had an endometrial biopsy in a local clinic which showed differentiated endometrioid carcinoma with trophoblastic components. High levels of β-Human chorionic gonadotropin (β-hCG) and alfa-fetoprotein (AFP) were detected in the patient's serum...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29684950/-metastases-of-urothelial-carcinoma-with-trophoblastic-differentiation-that-responded-to-combination-chemotherapy-with-gemcitabine-and-oxaliplatin-a-case-report
#17
Masahiro Uchida, Koji Kawai, Masahiro Kurobe, Atsushi Ikeda, Shuya Kandori, Tsuyoshi Endo, Tomoaki Miyagawa, Takahiro Kojima, Masakazu Tsutsumi, Hiroyuki Nishiyama
A 70-year-old man was admitted with complaint of gross hematuria. Cystoscopy and computed tomography (CT) revealed a 2.5 cm nodular tumor in the urinary bladder. Pathological diagnosis after the transurethral resection of bladder tumor (TURBT) was invasive urothelial cancer with trophoblastic differentiation of pT1. The tumor was positively stained with human chorionic gonadotropin (HCG). The serum HCG level was 12.8 IU/l in the fourth week after TURBT, and it increased to 35.7 IU/l in the 20th week after TURBT...
February 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29668580/metastatic-epithelioid-trophoblastic-tumor-of-the-lung-a-case-report
#18
Wangjun Lei, Fangbiao Zhang, Chunhui Zheng, Chun Zhao, Shaosong Tu, Yingwei Bao
RATIONALE: Epithelioid trophoblastic tumor (ETT) is a very rare form of gestational trophoblastic disease (GTD) which arises from neoplastic proliferation of intermediate trophoblasts. Metastatic ETT of the lung is extremely rare in postmenopausal women. PATIENT CONCERNS: Here we describe a 50-year-old woman with a metastatic ETT of the lung showing increasing tracer uptake at PET/CT. DIAGNOSIS: Hematoxylin-eosin staining showed a tumor composed of nests of epithelioid cells with necrotic debris and peritumoral hyaline-like material...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29665170/breast-carcinoma-in-pregnancy-with-spheroid-like-placental-metastases-a-case-report
#19
Karolin Froehlich, Hanne Stensheim, Udo R Markert, Gitta Turowski
Breast cancer is one of the most common malignancies diagnosed in pregnancy. Although the tumor is often detected at an advanced stage, placental metastases are rare. Here, we describe the case of a woman with breast cancer recurrence during pregnancy and subsequent metastases. The focus of this study is the large amount of placenta metastases, which have been analyzed immunohistochemically. Staining with trophoblast markers (placenta alkaline phosphatase, beta human chorionic gonadotropin and human placental lactogen) showed the strict localization of metastases in the intervillous space without invasion into fetal tissue...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29659388/imaging-of-metastatic-epithelioid-trophoblastic-tumor-with-18f-fdg-pet-ct
#20
Tirth Patel, Jorge Oldan
Epithelioid trophoblastic tumors are exceptionally rare malignant forms of gestational trophoblastic neoplasia arising from the placenta. We present here a case of a 33-year-old woman with an epithelioid trophoblastic tumor with metastatic disease to the lungs that was initially thought to represent cervical carcinoma. After appropriate diagnosis and treatment, the tumor responded to therapy and was in remission. The cancer recurred 5 years later with new lung metastases. F-FDG PET/CT was used for initial tumor staging, to evaluate treatment response, and to help detect the recurrence...
June 2018: Clinical Nuclear Medicine
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