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https://www.readbyqxmd.com/read/29642803/expression-of-n-acetylglucosaminyltransferase-iii-promotes-trophoblast-invasion-and-migration-in-early-human-placenta
#1
Qinyin Deng, Xiru Liu, Zhongmei Yang, Lan Xie
INTRODUCTION: Trophoblast migration and invasion at the maternal-fetal interface are crucial events for normal placentation and successful pregnancy. This progress is well controlled by many placenta-specific factors. Inadequate trophoblast invasion results in poor placenta plantation or even complications such as preeclampsia. It has been shown that N-acetylglucosaminyltransferase III (GnT-III) participates in tumor invasion and metastasis as a suppressor; however, the expression of GnT-III and its role in normal pregnancy is unclear...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29622835/diagnosing-and-treating-rare-lesions-in-a-low-resource-setting-lessons-from-ahybrid-epithelioid-trophoblastic-tumor-and-choriocarcinoma
#2
Patrick K Akakpo, Kofi Ulzen-Appiah, Evans Agbeno, Leonard Derkyi-Kwarteng
Objective: To raise awareness of the existence of a rare type of malignant trophoblastic tumor and discuss the diagnostic challenges and management of this lesion in a low resource setting. Case report and intervention: A 35 -year -old G6 P3 woman was referred to our facility on account of persistent vaginal bleeding due to a suspected incomplete miscarriage with a cervical mass. Her serum β-HCG was elevated (36,900 mIU/ml) and examination showed a bleeding cervical mass...
December 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29581140/transmission-of-a-tp53-germline-mutation-from-unaffected-male-carrier-associated-with-pediatric-glioblastoma-in-his-child-and-gestational-choriocarcinoma-in-his-female-partner
#3
Jennifer A Cotter, Linda Szymanski, Catherine Karimov, Lara Boghossian, Ashley Margol, Girish Dhall, Benita Tamrazi, G Isaac Varaprasathan, David M Parham, Alexander R Judkins, Jaclyn A Biegel
Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome caused by germline alterations in the tumor suppressor gene TP53. LFS is associated with numerous malignancies including astrocytoma. Sanger sequencing and chromosomal microarray studies of blood and tumor tissue from a 4-year-old boy with glioblastoma demonstrated a germline TP53 mutation with loss of heterozygosity for the short arm of chromosome 17 as the second inactivating event in the tumor. There was no family history of LFS, but the child's mother had recently died from metastatic choriocarcinoma after antecedent normal term delivery of a then 6-month-old daughter...
March 26, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29546798/metastatic-choriocarcinoma-masquerading-as-a-congenital-glabellar-hemangioma
#4
Steve Taylor, Kimberly Eisenstein, Vanessa Gildenstern, Harper Price, Pooja Hingorani, Apurvi Patel, Nathan Page, Smita Bailey, David Carpentieri
Infantile choriocarcinoma (ICC) is a rare, highly malignant form of gestational trophoblastic neoplasia. Rapid diagnosis and initiation of treatment are paramount in reaching a successful outcome. Patients with these tumors typically present with a triad of anemia, hepatomegaly, and precocious puberty. Cutaneous manifestations of ICC are extraordinarily rare with few documented cases. Here, we describe a male neonate who presented to our Dermatology clinic with a rapidly growing, markedly vascular glabellar mass associated with abnormal laboratory values suggestive of Kasabach-Merritt phenomenon...
January 1, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29546272/satb1-down-regulation-induced-by-oxidative-stress-participates-in-trophoblast-invasion-by-regulating-%C3%AE-catenin
#5
Haiying Rao, Yuxiang Bai, Qingshu Li, Baimei Zhuang, Yu Yuan, Yamin Liu, Wei Peng, Philip N Baker, Chao Tong, Xin Luo, Hongbo Qi
Preeclampsia (PE) is characterized by abnormal placentation in the early stages of pregnancy. Adequate migration and invasion of trophoblasts into the uterine wall and spiral arteries to form a functional maternal-fetal interface are pivotal for normal placentation, but the exact mechanism remains unclear. Growing evidence has revealed that special AT-rich sequence-binding protein 1 (SATB1) is a tumor promoter that participates in cancer cell migration and invasion. However, the expression and function of SATB1 in trophoblasts is unknown...
March 13, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29523298/the-role-of-trophoblastic-epigenetic-reprogrammation-in-benign-tumor-cells-on-malignant-progression-a-molecular-hypothesis
#6
Kevin Doello
Cancer tissues and placental ones share many properties such as invasiveness, metastasis and local immunosuppressive effects. The goal of the present article is to hypothesize a theory about cancer origin that links placental and cancerous tissues at molecular level. This hypothesis explain that cancer origin could be due to low hypoxic conditions in the peripheral zones of benign tumors which might up-regulate the expression of IGF2, and, consequently, trophoblastic genes. In fact, many phenotypic characteristics and molecular markers are shared between these two cell types (cancerous and trophoblastics ones), providing evidences to support this hypothesis...
April 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29473345/cgb5-expression-is-independently-associated-with-poor-overall-survival-and-recurrence-free-survival-in-patients-with-advanced-gastric-cancer
#7
Yuxin Yang, Yonghong Shi, Yanjuan Hou, Ying Lu, Jinliang Yang
The human CGB5 gene encodes chorionic gonadotropin (hCG)β 5, which is aberrantly expressed in trophoblastic neoplasm and in some non-trophoblastic neoplasms. Fucntional studies observed that it involved tumor initiation, growth, and metastatic outgrowth. In this study, using data from the International Cancer Genome Consortium (ICGC) and the Cancer Genome Atlas (TCGA)-stomach adenocarcinoma (STAD), we assessed the independent prognostic value of CGB5 expression in patients with primary gastric cancer (GC)...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29466889/downregulated-n-acetylglucosaminyltransferase-iii-is-involved-in-attenuating-trophoblast-migration-and-invasion-under-hypoxia-reoxygenation-condition
#8
Qinyin Deng, Nanlin Yin, Ying Chen, Nan Shan, Xiru Liu, Hongbo Qi
OBJECTIVE: Many studies have confirmed that N-acetylglucosaminyltransferase III (GnT-III) is correlated with tumor invasion and metastasis. However, the expression of GnT-III and its role in normal pregnancy and preeclampsia (PE) has not been reached. So the primary objective of this study is to determine GnT-III expression in normal pregnancy and whether its expression is vulnerable to oxidative stress in the trophoblast cells. METHODS: Human first trimester villous tissues from normal pregnancies and third trimester placentas from pregnancies with or without preeclampsia (PE) were used for the detection of GnT-III expression...
February 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29465790/forkhead-box-c2-promotes-the-invasion-ability-of-human-trophoblast-cells-through-hedgehog-hh-signaling-pathway
#9
Yuhong Zhang, Yangjia Zhang
Embryonic development depends on the normal invasion of trophoblast cells. Forkhead box C2 (FOXC2) is a member of Forkhead box family, which is involved in the tumor cells invasion. The aim of this study was to explore the roles of FOXC2 on the invasion of human trophoblast cells, and further study its molecular mechanism. The mRNA and protein levels of FOXC2 in human normal trophoblast and choriocarcinoma cell lines were analyzed by quantitative real-time PCR (qRT-PCR) and western blot assays, respectively...
February 21, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29447340/dysfunction-of-ddit4-in-the-decidua-is-relevant-to-the-pathogenesis-of-preeclampsia
#10
Jieqiong Yang, Yachao Zhang, Jing Tong, Hong Lv, Cong Zhang, Zi-Jiang Chen
Preeclampsia (PE) is a pregnancy-related disorder that occurs after 20 weeks of gestation and affects 3-5% of all human pregnancies worldwide. However, the pathogenesis of PE still remains poorly understood. A deficiency in decidualization is considered a contributing factor to the development of PE. The DNA damage inducible transcript 4 (DDIT4) gene encodes a protein whose main function is inhibiting mammalian target of rapamycin (mTOR) under stress, and several studies have demonstrated that its expression promotes tumor cell apoptosis...
February 13, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29436666/daidzein-induces-choriocarcinoma-cell-apoptosis-in-a-dose-dependent-manner-via-the-mitochondrial-apoptotic-pathway
#11
Wei Zheng, Teng Liu, Rong Sun, Lei Yang, Ruifang An, Yan Xue
Choriocarcinoma is a malignant gestational trophoblastic disease and relapse or drug resistance occurs in ~25% of gestational trophoblastic tumors. Cell apoptosis serves a role in the progression from hydatidiform mole to persistent gestational trophoblastic disease. It has been demonstrated that daidzein [7‑hydroxy‑3‑(4‑hydroxyphenyl)‑4H‑chromen‑4‑one] may induce apoptosis in a number of cancer types via the mitochondrial apoptotic pathway by altering the B‑cell lymphoma (Bcl)‑2/Bcl‑2 associated X, apoptosis regulator (Bax) ratio, and activating the caspase cascade...
February 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436119/laparoscopic-diagnosis-and-treatment-of-an-isolated-epithelioid-trophoblastic-tumor-in-recto-uterine-pouch
#12
Fang Jiang, Yang Xiang, Li-Na Guo
A 30-year-old Chinese woman with irregular vaginal bleeding was admitted to our department. Serum β-human chorionic gonadotropin (β-hCG) was moderately elevated, and ultrasound and magnetic resonance imaging revealed an irregular, retro-uterine lesion without intrauterine pregnancy. Ectopic pregnancy was the primary consideration, with trophoblastic tumor being another possibility. Laparoscopy revealed a 2 × 3 × 3 cm3 irregular, infiltrating, yellow-white lesion in the left recto-uterine pouch, which was completely resected without rectal damage...
February 13, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29432428/plac1-as-a-serum-biomarker-for-breast-cancer
#13
Hongyan Yuan, Vincent Chen, Marc Boisvert, Claudine Isaacs, Robert I Glazer
Placental-specific protein 1 (PLAC1) is an X-linked trophoblast gene that is re-expressed in several malignancies, including breast cancer, and is therefore a potential biomarker to follow disease onset and progression. Sera from 117 preoperative/pretreatment breast cancer patients and 51 control subjects, including those with fibrocystic disease, were analyzed for the presence of PLAC1 protein as well as its expression by IHC in tumor biopsies in a subset of subjects. Serum PLAC1 levels exceeded the mean plus one standard deviation (mean+SD) of the level in control subjects in 67% of subjects with ductal carcinoma in situ (DCIS), 67% with HER2+ tumors, 73% with triple-negative cancer and 73% with ER+/PR+ tumors...
2018: PloS One
https://www.readbyqxmd.com/read/29426237/targeted-delivery-of-doxorubicin-by-csa-binding-nanoparticles-for-choriocarcinoma-treatment
#14
Baozhen Zhang, Guogang Cheng, Mingbin Zheng, Jinyu Han, Baobei Wang, Mengxia Li, Jie Chen, Tianxia Xiao, Jian Zhang, Lintao Cai, Shoujun Li, Xiujun Fan
Gestational trophoblastic neoplasia (GTN) can result from the over-proliferation of trophoblasts. Treatment of choriocarcinoma, the most aggressive GTN, currently requires high doses of systemic chemotherapeutic agents, which result in indiscriminate drug distribution and severe toxicity. To overcome these disadvantages and enhance the chemotherapeutic efficacy, chondroitin sulfate A (CSA)-binding nanoparticles were developed for the targeted delivery of doxorubicin (DOX) to choriocarcinoma cells using a synthetic CSA-binding peptide (CSA-BP), derived from malarial protein, which specifically binds to the CSA exclusively expressed in the placental trophoblast...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29397019/use-of-circulating-tumor-cells-in-prospective-clinical-trials-for-nsclc-patients-standardization-of-the-pre-analytical-conditions
#15
Marius Ilie, Véronique Hofman, Sylvie Leroy, Charlotte Cohen, Simon Heeke, Florian Cattet, Coraline Bence, Salomé Lalvée, Jérôme Mouroux, Charles-Hugo Marquette, Paul Hofman
BACKGROUND: Circulating tumor cells (CTCs) hold potential for noninvasive diagnosis, prognosis and prediction testing in non-small cell lung cancer (NSCLC) patients. Minimizing degradation or loss of CTCs is pivotal for detection and profiling of the low abundance and fragile CTCs, particularly in clinical trials. We prospectively investigated (NCT02372448) whether a new blood collection device performed better compared to commonly used K3EDTA tubes, when subjected to long-term sample storage...
February 3, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29395947/placental-site-trophoblastic-tumor-in-nonseminomatous-mixed-germ-cell-tumors-of-the-testis-a-case-report-and-review-of-the-literature
#16
Joëlle Razafimahefa, Clément Gosset, Stéphane Culine, Pierre Mongiat-Artus, Jérôme Verine
No abstract text is available yet for this article.
December 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29390471/early-pregnancy-following-multidrug-regimen-chemotherapy-in-a-gestational-trophoblastic-neoplasia-patient-a-case-report
#17
Gang Niu, Lin-Jing Yuan, Feng-Qiu Gong, Juan Yang, Cai-Xia Zhu, Hong-Wei Shen
RATIONALE: Gestational trophoblastic neoplasia is a group of rare tumors that can be cured using chemotherapy. The use of artificial contraception for at least 1 year is recommended not only due to the high recurrence rate in the first year after treatment, but also because of the unclear genetic toxic effects of multidrug regimen chemotherapy on reproductive cells. There is no consensus about the contraception duration, but most patients want to have children. PATIENT CONCERNS: This case involved a 33-year-old female suffering from gestational trophoblastic neoplasia and 5-fluorouracil + actinomycin-D chemotherapy...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29357321/b-subunit-of-human-chorionic-gonadotropin-promotes-tumor-invasion-and-predicts-poor-prognosis-of-early-stage-colorectal-cancer
#18
Jiali Li, Mingzhu Yin, Wanjing Song, Fengyun Cui, Wei Wang, Shuyang Wang, Hongguang Zhu
BACKGROUND/AIMS: It is well established that many non-trophoblastic tumors secrete HCG (human chorionic gonadotropin) and that such secretion is correlated with the poor prognosis of tumor patients. This study aims to analyze the correlation between β-HCG expression and outcome of colorectal cancer (CRC) and understand its role in CRC pathology Methods: We detected the mRNA and protein expression of β-HCG in human CRC tissues with RT-qPCR and immunohistochemistry, and we compared the clinical-pathological characteristics, prognosis and progression between the β-HCG positive and negative groups...
January 22, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29324534/reproductive-outcomes-after-gestational-trophoblastic-neoplasia-a-comparison-between-single-agent-and-multiagent-chemotherapy-retrospective-analysis-from-the-mito-9-group
#19
Raffaella Cioffi, Alice Bergamini, Angiolo Gadducci, Gennaro Cormio, Veronica Giorgione, Micaela Petrone, Emanuela Rabaiotti, Francesca Pella, Massimo Candiani, Giorgia Mangili
OBJECTIVES: Gestational trophoblastic neoplasia affects women of reproductive age and is usually treated by chemotherapy. Major concerns related to chemotherapy in young women are the possible infertility, risk of early menopause, and teratogenic effects on subsequent pregnancies. The study's aim was to analyze menstrual and reproductive outcomes of women treated with single-agent versus multiagent chemotherapy for gestational trophoblastic neoplasia. METHODS: One-hundred fifty-one patients were treated...
February 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29307244/the-role-of-satb1-in-htr8-svneo-cells-and-pathological-mechanism-of-preeclampsia
#20
Haiying Rao, Yuxiang Bai, Fumei Zhang, Qingshu Li, Baimei Zhuang, Xin Luo, Hongbo Qi
OBJECTIVE: Special AT-rich sequence binding protein 1 (SATB1) play potential roles in invasion and metastasis of tumor cells, and involves in human placental and fetal development. The objective of this study is to explore the role of SATB1 in migration and invasion of trophoblast and the potential mechanism. METHODS: Human placental tissues from first trimester, second trimester, term, and preeclampsia (PE) pregnancies were used to detect the expression and subcellular location of SATB1 and β-catenin...
January 16, 2018: Journal of Maternal-fetal & Neonatal Medicine
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