keyword
MENU ▼
Read by QxMD icon Read
search

Trophoblastic tumor

keyword
https://www.readbyqxmd.com/read/28795129/placental-site-trophoblastic-tumor-with-sole-metastasis-to-breast-a-case-report
#1
Kimberly Nagamine, Sophia Iwasaki, David Shimizu, Pamela Tauchi-Nishi, Keith Terada
Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia (GTN). It most commonly occurs after a delivery but may arise after any type of pregnancy. PSTT arises after neoplastic transformation of intermediate trophoblastic cells. The most commonly reported symptoms are abnormal bleeding or amenorrhea. Due to the rarity of this disease, evidence on prognostic factors as well as optimal treatment is limited. While treatment for early-stage disease is usually limited to surgery, multimodal treatment with chemotherapy and surgery may be important for metastatic disease...
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28763083/-squamous-cell-carcinoma-in-situ-of-the-cervix-and-placental-site-nodule-case-report
#2
María Constanza Gómez, María Claudia Abaúnza, Elga Johanna Vargas, Inés Acosta
An asymptomatic 24-year-old woman underwent a colposcopy, cervical biopsy, and subsequently, a conization for a cervical squamous cell carcinoma in situ with glandular extension. Simultaneously, an endometrial biopsy was carried out in which, incidentally, a placental site nodule was diagnosed, a rare non-neoplastic lesion originating in the intermediate trophoblast. Given the coexistence of these two entities, it was necessary to make a differential diagnosis between them and also with other pathologies of the trophoblast such as an exaggerated placental site, placental site trophoblastic tumor, and epithelioid trophoblastic tumor...
May 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28759528/18f-fdg-pet-ct-demonstrating-chorioadenoma-destruens-after-evacuation-of-complete-hydatidiform-mole
#3
Punit Sharma
Gestational trophoblastic neoplasias (GTNs) are a group of pregnancy-related neoplasms, which include chorioadenoma destruens (invasive mole), placental site trophoblastic tumor, and choriocarcinoma. Although the role of F-FDG PET/CT is still undefined in GTN, in selected cases, it can have significant impact on patient management. Here, we present the case of a 29-year-old woman with hydatidiform mole suggestive of GTN 3 months after evacuation. F-FDG PET/CT demonstrated chorioadenoma destruens (invasive mole) and ruled out metastasis in this case...
July 29, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28713970/human-chorionic-gonadotropin%C3%A2-%C3%AE-regulates-epithelial-mesenchymal-transition-and-metastasis-in-human-ovarian-cancer
#4
Na Liu, Shu-Min Peng, Guang-Xi Zhan, Jing Yu, Wei-Min Wu, Hao Gao, Xiao-Feng Li, Xiao-Qing Guo
Human chorionic gonadotropin β (β-hCG) is a well-known and accurate marker for the diagnosis and monitoring of pregnancy, trophoblastic tumors and ovarian germ cell tumors. Recently, β-hCG has been found to be closely related to poor prognosis and metastasis in various other malignant tumors, while its role and mechanism in ovarian cancer is still unclear. In the present study, lentiviral‑mediated transfection and small interfering RNA (siRNA) were used to alter β-hCG expression in the ovarian cancer cell lines ES-2 and SKOV3, respectively...
July 14, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28704852/pregnancy-and-tumor-outcomes-in-women-with-prolactinoma
#5
Bárbara Araujo, Sandra Belo, Davide Carvalho
Context Management of prolactinomas during pregnancy has always been a challenge. There is a concern about the risk of tumor growth, as well as the effects of the treatment on the developing fetus. Another issue that has been less studied is the outcome of women with prolactinoma after pregnancy and lactation. Objectives To evaluate remission of hyperprolactinaemia after pregnancy and lactation in women with prolactinoma. To describe the safety of dopamine agonists for the fetus and pregnancy outcomes. Methods A retrospective study of 32 pregnancies in women with prolactinoma was conducted in a single-centre...
July 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28700434/comparison-of-p63-and-p40-immunohistochemical-stains-to-distinguish-epithelioid-trophoblastic-tumor-from-other-trophoblastic-lesions
#6
Whitney A McCarthy, Cherie Paquette, Fusun Gundogan, W Dwayne Lawrence
No abstract text is available yet for this article.
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28674676/hypothesis-about-transdifferentiation-as-backbone-of-malignancy
#7
Jean Piechowski
BACKGROUND: Cancer is mainly watched through the prism of random mutations and related corruption of signaling pathways. However, it would seem puzzling to explain the tumor organization, pugnacity and steady evolution of the tumorous disease and, moreover, a systematic ascendancy over the healthy tissues, only through stochastic genomic alterations. MALIGNANCY SPECIFIC PROPERTIES: Considering the core characteristics of cancer cells, it appears that two major sets of properties are emerging, corresponding to well-identified physiological phenotypes, i...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28614227/case-report-of-pulmonary-epithelial-trophoblastic-tumor-in-a-young-female-patient
#8
Lijun Jiang, Hongfei Xu, Yuan Lu, Weidong Li, Chengfei Zheng
INTRODUCTION: An epithelial trophoblastic tumor (ETT) is a kind of rare trophoblastic tumor that may have the correlation with a prior gestational event. Especially, the one that appears in the lung is extremely rare. CASE SUMMARY: Here, we present a 24-year-old female patient with the chief complain of vaginal bleeding for more than 1 month, who was found to have a large mass (7.5 × 4.5 cm) in the right lower lobe, and it was finally confirmed as lung ETT by postoperative pathology after a successful radical resection of the pulmonary lobe...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28592902/ggnbp2-is-necessary-for-testis-morphology-and-sperm-development
#9
Anqi Chen, Jixi Li, Lesheng Song, Chaoneng Ji, Marion Böing, Jinzhong Chen, Beate Brand-Saberi
Gametogenetin Binding Protein 2 (GGNBP2) was identified as a tumor suppressor and verified as such by several studies. GGNBP2 has also been reported to be essential for pregnancy maintenance via regulation of trophoblast stem cells. Gametogenetin (GGN) is a testicular germ cell-specific gene expressed in adult testes. As a potential GGN1-interacting protein, the role of GGNBP2 in spermatogenesis has not yet been clarified. We generated heterozygous GGNBP2 knockout mice and bred them by intercrossing. We found that among the offspring, homozygous GGNBP2 knockout (KO) mice were present in severely reduced numbers...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28590345/two-cases-of-epithelioid-trophoblastic-tumors-in-postmenopausal-women
#10
Adriano Rodríguez-Trujillo, María José Martínez-Serrano, Adela Saco, Aureli Torné
OBJECTIVE: Epithelioid trophoblastic tumor is a rare gestational trophoblastic neoplasm usually presenting in women of reproductive age, with a history of a prior gestational event. Its presentation in postmenopausal women is extremely rare. Immunohistochemical staining is a helpful aid to distinguish epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. Correct diagnosis is crucial for clinical management that can vary according to the type of gestational trophoblastic neoplasm...
June 5, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28587570/effect-of-lactobacillus-rhamnosus-gr-1-supernatant-on-cytokine-and-chemokine-output-from-human-amnion-cells-treated-with-lipoteichoic-acid-and-lipopolysaccharide
#11
Rebecca J E Koscik, Gregor Reid, Sung O Kim, Wei Li, John R G Challis, Alan D Bocking
Preterm birth occurs in 9% to 13% of all human pregnancies and accounts for 80% of all neonatal morbidities and mortalities. Approximately 40% of all preterm births are idiopathic and about half are associated with infection and/or an activated inflammatory process. Further to studies showing anti-inflammatory effects of supernatant from the probiotic Lactobacillus rhamnosus GR-1 (GR-1), we tested its ability to modulate cytokine and chemokine production from amnion cells in response to stimulation by bacterial wall components, lipopolysaccharide (LPS), and lipoteichoic acid (LTA)...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28582346/endometrial-carcinoma-with-trophoblastic-components-clinicopathologic-analysis-of-a-rare-entity
#12
Kojo R Rawish, Natalia Buza, Wenxin Zheng, Oluwole Fadare
Somatic endometrial carcinomas with trophoblastic components have only rarely been described. To better characterize this distinctive combination of histotypes, we report herein 4 new cases, representing the largest cohort reported thus far, and review previously reported cases. The 4 new patients ranged in age from 61 to 77 yr (mean, 68 yr). The first patient had a grade 2 endometrioid carcinoma, surgical International Federation of Gynecology and Obstetrics stage IA, that recurred 5 months later at the vaginal apex with purely choriocarcinoma elements, suggestive of unsampled trophoblastic areas in the uterus...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28567335/rare-presentation-of-metastatic-cystic-trophoblastic-tumor-in-a%C3%A2-patient-without-prior-chemotherapy
#13
Michael L Wang, Jonathan B McHugh, Alon Z Weizer, Todd M Morgan, Arul M Chinnaiyan, Andrew P Sciallis, Amir Lagstein, Daniel E Spratt, Rohit Mehra
Cystic trophoblastic tumor (CTT) is a rare testicular germ cell tumor (GCT) predominantly seen in post-chemotherapy patients. It is prognostically similar to teratoma and requires no additional chemotherapy in the absence of a nonteratomatous GCT component. We report a case of metastatic CTT in a patient with primary testicular teratoma without prior chemotherapy. Retroperitoneal lymph node metastases contained teratoma, embryonal carcinoma, and CTT. The CTT was β-hCG positive and SALL4 negative by immunohistochemistry (IHC)...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28548328/epithelioid-trophoblastic-tumor-of-the-uterus-a-case-report-with-radiologic-pathologic-correlation
#14
Ayumi Ohya, Kayoko Higuchi, Hisashi Shimojo, Yasunari Fujinaga, Masumi Kadoya, Shigeki Shiohara
Herein, we report a rare case of an epithelioid trophoblastic tumor of the uterus with radiologic-pathologic correlation in a 56-year-old postmenopausal woman. On T2-weighted magnetic resonance (MR) imaging, the tumor appeared as a hypointense irregular mass compared with the surrounding myometrium of the uterine corpus and encircled the cavity of the lower uterine segment. On dynamic contrast-enhanced MR images, the tumor appeared as a hypovascular mass and an inhomogeneously hyperintense mass in the delayed phase...
May 26, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28546716/complete-molar-pregnancy-in-postmenopausal-woman
#15
Ahmed Samy El-Agwany, Helmy Abdelsattar Rady, Hassan Mansour Hegab
Gestational trophoblastic disease spectrum ranges from benign hydatidiform mole to trophoblastic malignancy (placental site trophoblastic tumor and choriocarcinoma). Benign gestational trophoblastic disease occurs in women of reproductive age and is extremely rare in postmenopausal women. We describe a case of complete vesicular mole in a 55-year-old postmenopausal woman complaining of postmenopausal bleeding. To our knowledge, our case represents one of the rare descriptions in the world literature of a benign complete hydatidiform mole in a postmenopausal woman...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28493802/placental-imaging-normal-appearance-with-review-of-pathologic-findings
#16
Shaimaa Fadl, Mariam Moshiri, Corinne L Fligner, Douglas S Katz, Manjiri Dighe
The placenta plays a crucial role throughout pregnancy, and its importance may be overlooked during routine antenatal imaging evaluation. Detailed systematic assessment of the placenta at ultrasonography (US), the standard imaging examination during pregnancy, is important. Familiarity with the normal and abnormal imaging appearance of the placenta along with the multimodality and methodical approach for evaluation of its related abnormalities is necessary, so that radiologists can alert clinicians regarding appropriate prompt management decisions...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28491173/radiographically-occult-pulmonary-metastases-from-gestational-trophoblastic-neoplasia
#17
Tina Hong, Edward Hills, Maria Del Pilar Aguinaga
Gestational trophoblastic neoplasia (GTN) is a spectrum of diseases including partial and complete hydatidiform moles, placental site trophoblastic tumor, and choriocarcinoma. One of the most important considerations is recognition of the possibility of GTN after molar pregnancy or even normal pregnancy. It is common practice to use chest x-ray for the detection of pulmonary metastasis. Computed tomography imaging of the lungs is ordered if lung lesions are noted on chest x-rays. However, understanding the limitations of chest x-rays is important for detecting smaller pulmonary lesions...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28481180/trophoblast-glycoprotein-tpgb-5t4-in-human-placenta-expression-regulation-and-presence-in-extracellular-microvesicles-and-exosomes
#18
S M K Alam, S Jasti, S K Kshirsagar, D S Tannetta, R A Dragovic, C W Redman, I L Sargent, H C Hodes, T L Nauser, T Fortes, A M Filler, K Behan, D R Martin, T A Fields, B K Petroff, M G Petroff
BACKGROUND: Many parallels exist between growth and development of the placenta and that of cancer. One parallel is shared expression of antigens that may have functional importance and may be recognized by the immune system. Here, we characterize expression and regulation of one such antigen, Trophoblast glycoprotein (TPGB; also called 5T4), in the placenta across gestation, in placentas of preeclamptic (PE) pregnancies, and in purified microvesicles and exosomes. METHODS: Trophoblast glycoprotein expression was analyzed by real-time reverse transcription-polymerase chain reaction (RT-PCR), Western blot, and immunohistochemistry...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28474163/-germ-cell-and-sex-cord-stromal-tumors-of-the-testis-who-classification-2016
#19
G Mikuz
Earlier revisions of the WHO classification of testicular tumors, which was originally published in 1977, contained only minor additions. In the WHO 2016 classification, in contrast, germ cell tumors are split into two major groups based on their distinct pathohistogenesis, i. e., those which derive from an in situ forerunner lesion and those which do not. The latter category includes prepubertal yolk sac tumors and teratomas, as well as spermatocytic seminoma. The classification of yolk sac tumors and teratomas as arising before or after puberty is also of prognostic value...
May 4, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28473205/salvage-chemotherapy-for-gestational-trophoblastic-neoplasia-utility-or-futility
#20
Kathleen G Essel, Amanda Bruegl, David M Gershenson, Lois M Ramondetta, R Wendel Naumann, Jubilee Brown
OBJECTIVE: To determine the efficacy of chemotherapy after failed initial treatment in patients with high risk gestational trophoblastic neoplasia (GTN). METHODS: We performed a retrospective IRB-approved chart review of all patients with GTN seen at a single institution from 1985 to 2015, including all patients who failed initial treatment. We summarized clinical characteristics with descriptive statistics and estimated progression-free survival (PFS) and overall survival (OS) with the Kaplan-Meier method...
July 2017: Gynecologic Oncology
keyword
keyword
8882
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"