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Trophoblastic tumor

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https://www.readbyqxmd.com/read/28423362/trop2-promotes-proliferation-migration-and-metastasis-of-gallbladder-cancer-cells-by-regulating-pi3k-akt-pathway-and-inducing-emt
#1
Xinxing Li, Shifeng Teng, Yanyan Zhang, Weigang Zhang, Xianwen Zhang, Kai Xu, Houshan Yao, Jun Yao, Haolu Wang, Xiaowen Liang, Zhiqian Hu
The human trophoblast cell surface antigen 2 (TROP2) is overexpressed in many cancers. However, its effect on proliferation, migration and metastasis of gallbladder cancer remains unclear. In this study, we found that TROP2 was highly expressed in gallbladder cancer. Overexpression of TROP2 was associated with poor prognosis. Knockdown of TROP2 in gallbladder cancer cell lines strongly inhibited the cell proliferation, clone formation, invasion and migration in vitro, while TROP2 overexpression had opposite effects...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422548/epidemiological-profile-and-treatment-outcomes-in-young-adults-19-29-years-of-age-treated-for-cancer-in-a-tertiary-hospital-in-s%C3%A3-o-paulo-brazil
#2
Victor Hugo Fonseca de Jesus, Taynan Nunes Ribeiro, Ludmilla T Domingos Chinen, Vanessa Alves, Maria Paula Curado, Marcello Ferretti Fanelli
BACKGROUND: Worldwide, the incidence of cancer in young adults (20-39 years) is increasing, and represents an important cause of mortality in this age group. A retrospective study was undertaken to provide information that may lead to improved treatment outcomes. METHODS: Epidemiological, clinicopathological, treatment, and survival information were retrieved from the electronic database registry of a tertiary referral hospital in São Paulo, Brazil for patients 19-29 years of age diagnosed with cancer between January 2007 and December 2012...
April 19, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28413543/primary-intracranial-choriocarcinoma-presenting-as-a-ring-enhancing-lesion-a-case-report-and-review-of-literature
#3
Mayur Sharma, Vernon Velho, Rachana Binayake, Chandranath Tiwari
We report here a rare case of primary intracranial choriocarcinoma without evidence of tumor elsewhere, presenting as a ring-enhancing lesion managed successfully in our institute (Grant Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India). A 22-year-old, right-handed housewife presented with complaints of headache, vomiting, generalized tonic-clonic seizures, and right upper limb weakness of short duration. On neurological examination, the patient was conscious, cooperative, well-oriented in time, place, and person...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28401076/presentation-of-placental-site-trophoblastic-tumor-with-amenorrhea
#4
Fariba Behnamfar, Safoura Rouholamin, Mahboubeh Esteki
Placental site throphoblastic tumor (PSTT) is a rare manifestation of gestational trophoblastic neoplasia that may complicate any type of pregnancy. The disease is unique from other type, and is defined by slow growth, low human chorionic gonadotropin (hCG) serum levels, the late-onset metastatic potential, and most significantly, insensitivity to chemotherapy. We describe a case of a 31-year-old woman with prolonged amenorrhea and slightly elevated serum beta hCG (βhCG) level, referred for termination of abnormal pregnancy...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28390821/the-added-value-of-hysterectomy-in-the-management-of-gestational-trophoblastic-neoplasia
#5
Y K Eysbouts, L F A G Massuger, J IntHout, C A R Lok, F C G J Sweep, P B Ottevanger
BACKGROUND: Despite the undoubted effectiveness of chemotherapeutic treatment in gestational trophoblastic neoplasia (GTN), problems related to toxicity of chemotherapy and chemo-resistant disease have led to reconsideration of the use of hysterectomy. Aim of the present study was to evaluate indications for and outcome of hysterectomy in patients with GTN in a nation-wide cohort. METHODS: Between 1977 and 2012, we identified all patients diagnosed with GTN and treated with hysterectomy from the Dutch national databases...
April 5, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28380025/effect-of-proline-rich-15-deficiency-on-trophoblast-viability-and-survival
#6
Katherine C Gates, Lindsey N Goetzmann, Jeremy D Cantlon, Kimberly M Jeckel, Russell V Anthony
Deviations from the normal program of gene expression during early pregnancy can lead to early embryonic loss as well as dysfunctional placentation, which can cause significant morbidity and mortality. Proline rich 15 (PRR15) is a low molecular weight nuclear protein expressed by the trophoblast during early gestation. Lentivirus-mediated knockdown of PRR15 mRNA in ovine trophectoderm led to demise of the embryo by gestational day 15, providing compelling evidence that PRR15 expression is critical during this precarious window of development...
2017: PloS One
https://www.readbyqxmd.com/read/28377901/unusual-presentation-of-invasive-mole-a-case-report
#7
Soheila Aminimoghaddam, Andisheh Maghsoudnia
BACKGROUND: Invasive mole is responsible for most cases of localized gestational trophoblastic neoplasia. Gestational trophoblastic disease describes a number of gynecologic tumors that originate in trophoblastic layer including hydatidiform mole (complete or partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor and epitheloid trophoblastic tumor. Invasive mole may arise from any pregnancy event although in most cases is diagnosed after molar pregnancy. Overall cure rate in low risk patients is nearly 100% and in high-risk patient 90%...
January 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28375929/placenta-specific-protein-1-expression-in-human-papillomavirus-16-18-positive-cervical-cancers-is-associated-with-tumor-histology
#8
Eric J Devor, Henry D Reyes, Jesus Gonzalez-Bosquet, Akshaya Warrier, Susan A Kenzie, Nonye V Ibik, Marina D Miller, Brandon M Schickling, Michael J Goodheart, Kristina W Thiel, Kimberly K Leslie
OBJECTIVE: Expression of the trophoblast-specific gene placenta-specific protein 1 (PLAC1) has been detected in a wide variety of cancers. However, to date, PLAC1 expression has not been shown in cervical cancer. We have carried out a preliminary study that shows for the first time that PLAC1 is expressed in cervical cancers. METHODS: A total of 16 primary cervical tumors were obtained from patients shown to be human papillomavirus (HPV) 16/18 positive. Total cellular RNA, genomic DNA, and total protein were purified from each tumor...
April 3, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28302141/dna-hypomethylation-and-aberrant-expression-of-the-human-endogenous-retrovirus-ervwe1-syncytin-1-in-seminomas
#9
Martina Benešová, Kateřina Trejbalová, Denisa Kovářová, Zdenka Vernerová, Tomáš Hron, Dana Kučerová, Jiří Hejnar
BACKGROUND: Syncytin-1 and 2, human fusogenic glycoproteins encoded by the env genes of the endogenous retroviral loci ERVWE1 and ERVFRDE1, respectively, contribute to the differentiation of multinucleated syncytiotrophoblast in chorionic villi. In non-trophoblastic cells, however, the expression of syncytins has to be suppressed to avoid potential pathogenic effects. Previously, we have shown that the transcriptional suppression of ERVWE1 promoter is controlled epigenetically by DNA methylation and chromatin modifications...
March 17, 2017: Retrovirology
https://www.readbyqxmd.com/read/28296679/primary-cystic-trophoblastic-tumor-of-the-testis-a-study-of-14-cases
#10
Dibson D Gondim, Thomas M Ulbright, Liang Cheng, Muhammad T Idrees
Cystic trophoblastic tumor (CTT) has been described in postchemotherapy retroperitoneal lymph node dissections of patients with testicular germ cell tumors. Prognostically, this lesion is similar to teratoma and no further treatment is required after surgery in the absence of other components. CTT has not, however, been reported in the testis. We identified 14 CTTs in the treated (4) and untreated (9; no information for 1 patient) testes of patients 15 to 43 years old (median, 25) with mixed germ cell tumors...
March 14, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28287945/gestational-trophoblastic-disease-clinical-and-imaging-features
#11
Akram M Shaaban, Maryam Rezvani, Reham R Haroun, Anne M Kennedy, Khaled M Elsayes, Jeffrey D Olpin, Mohamed E Salama, Bryan R Foster, Christine O Menias
Gestational trophoblastic disease (GTD) is a spectrum of both benign and malignant gestational tumors, including hydatidiform mole (complete and partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. The latter four entities are referred to as gestational trophoblastic neoplasia (GTN). These conditions are aggressive with a propensity to widely metastasize. GTN can result in significant morbidity and mortality if left untreated. Early diagnosis of GTD is essential for prompt and successful management while preserving fertility...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28254207/unusual-clinical-presentations-of-choriocarcinoma-a-systematic-review-of-case-reports
#12
REVIEW
Mishu Mangla, Deepak Singla, Harpreet Kaur, Sushmita Sharma
Choriocarcinoma (CC) is a highly malignant tumor originating in the trophoblastic tissue. The clinical presentation of CC is so much varied that every case may be one of its kinds and thus can be a diagnostic challenge. Numerous case reports have been published in various journals regarding the unusual clinical presentations of this cancer. Therefore, we conducted a systematic review of all case reports in English language on gestational CC published in PubMed-indexed journals from 1998 to 2015. The main aim was to provide a summary and critical analysis of all the data and evidence published regarding the atypical clinical presentations of CC in recent years...
February 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28217684/extrauterine-epithelioid-trophoblastic-tumor-in-hysterectomized-woman
#13
Ji-Hye Kim, Sun Kyung Lee, Soo Hyun Hwang, Jung-Sun Kim, Gun Yoon, Yoo-Young Lee, Tae-Joong Kim, Chel Hun Choi, Byoung-Gie Kim, Duk-Soo Bae, Jeong-Won Lee
Epithelioid trophoblastic tumor (ETT) is a very rare variant of gestational trophoblastic disease (GTD) which arises in reproductive age women with prior gestational history. Although abnormal vaginal bleeding is the most common symptom of ETT, there are no reported pathognomonic symptoms of ETT because of its rarity. ETT is similar to placental site trophoblastic tumor in terms of its slow growing characteristic and microscopic findings. Therefore, it could be misdiagnosed as placental site trophoblastic tumor or other types of GTD...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28161066/genomic-profile-in-gestational-and-non-gestational-choriocarcinomas
#14
Julia Bette Homem de Mello, Priscila Daniele Ramos Cirilo, Odair Carlito Michelin, Maria Aparecida Custódio Domingues, Marilza Vieira Cunha Rudge, Silvia Regina Rogatto, Izildinha Maestá
INTRODUCTION: Gestational (GC) (derived from the placenta) and non-gestational (NGC) choriocarcinomas are trophoblastic diseases originated from abnormal proliferation of trophoblastic cells. These rare tumors share similar morphology and pathological features and differ on chemotherapy response, genetic origin and prognosis. In this study, the genomic profile of choriocarcinomas was performed according to their origin (GC or NGC) aiming to better understand these poorly characterized diseases...
February 2017: Placenta
https://www.readbyqxmd.com/read/28161055/maternal-type-1-diabetes-activates-stress-response-in-early-placenta
#15
Martin Gauster, Alejandro Majali-Martinez, Sabine Maninger, Elisabeth Gutschi, Patrick H Greimel, Marina Ivanisevic, Josip Djelmis, Gernot Desoye, Ursula Hiden
INTRODUCTION: Human pregnancy and in particular the first trimester, is a period highly susceptible towards adverse insults such as oxidative stress, which may lead to inadequate embryonic and feto-placental development. Diabetes mellitus is associated with increased oxidative stress caused by hyperglycemia, reactive oxygen species (ROS) production and inflammatory signals. In pregnancy, diabetes elevates the risk for early pregnancy loss, preeclampsia and fetal growth restriction, pathologies that origin from early placental maldevelopment...
February 2017: Placenta
https://www.readbyqxmd.com/read/28134999/pathogenesis-of-hyperthyroidism
#16
Ishita Singh, Jerome M Hershman
Hyperthyroidism is a form of thyrotoxicosis in which there is excess thyroid hormone synthesis and secretion. Multiple etiologies can lead to a common clinical state of "thyrotoxicosis," which is a consequence of the high thyroid hormone levels and their action on different tissues of the body. The most common cause of thyrotoxicosis is Graves' disease, an autoimmune disorder in which stimulating thyrotropin receptor antibodies bind to thyroid stimulating hormone (TSH) receptors on thyroid cells and cause overproduction of thyroid hormones...
December 6, 2016: Comprehensive Physiology
https://www.readbyqxmd.com/read/28134666/epithelioid-trophoblastic-tumor-around-an-abdominal-cesarean-scar-a-pathologic-and-molecular-genetic-analysis
#17
Emily Han-Chung Hsiue, Chiun Hsu, Li-Hui Tseng, Tzu-Pin Lu, Kuan-Ting Kuo
Epithelioid trophoblastic tumor (ETT) is a rare chemoresistant gestational trophoblastic neoplasm that typically presents as an intrauterine lesion. To our knowledge, no isolated abdominal wall ETT around a Cesarean scar has been reported. Here we describe a 54-yr-old woman with a complex obstetric history who presented with a solitary abdominal wall tumor adjacent to the abdominal Cesarean section scar. The tumor demonstrated typical morphologic and immunophenotypic features of ETT. The gestational origin of the tumor was confirmed by microsatellite genotyping...
January 27, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28118159/clear-cell-carcinoma-of-the-cervix-with-choriocarcinomatous-differentiation-report-of-an-extremely-rare-phenomenon-associated-with-mismatch-repair-protein-abnormality
#18
Pinias Mukonoweshuro, W Glenn McCluggage
The presence of trophoblastic differentiation or nongestational choriocarcinoma in a carcinoma is rare but has been described in various organs, including in the female genital tract. We report a cervical clear cell carcinoma admixed with a component of choriocarcinoma in a 52-year-old woman, only the second report of this combination in the literature. Immunohistochemically, the tumor exhibited isolated loss of staining with the mismatch repair protein MSH6. We review the literature on trophoblastic differentiation in cervical carcinoma...
December 12, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28115513/proton-pump-inhibitors-decrease-soluble-fms-like-tyrosine-kinase-1-and-soluble-endoglin-secretion-decrease-hypertension-and-rescue-endothelial-dysfunction
#19
Kenji Onda, Stephen Tong, Sally Beard, Natalie Binder, Masanaga Muto, Sevvandi N Senadheera, Laura Parry, Mark Dilworth, Lewis Renshall, Fiona Brownfoot, Roxanne Hastie, Laura Tuohey, Kirsten Palmer, Toshihiko Hirano, Masahito Ikawa, Tu'uhevaha Kaitu'u-Lino, Natalie J Hannan
Preeclampsia is a severe complication of pregnancy. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin are secreted in excess from the placenta, causing hypertension, endothelial dysfunction, and multiorgan injury. Oxidative stress and vascular inflammation exacerbate the endothelial injury. A drug that can block these pathophysiological steps would be an attractive treatment option. Proton pump inhibitors (PPIs) are safe in pregnancy where they are prescribed for gastric reflux...
March 2017: Hypertension
https://www.readbyqxmd.com/read/28112754/gdm-alters-paracrine-regulation-of-feto-placental-angiogenesis-via-the-trophoblast
#20
Jelena Loegl, Erika Nussbaumer, Silvija Cvitic, Berthold Huppertz, Gernot Desoye, Ursula Hiden
Feto-placental angiogenesis and vascular development are tightly regulated by pro- and anti-angiogenic factors. Villous trophoblast may be a major source of these factors. It forms the classical placental barrier between mother and fetus, and is thus exposed to maternal influences as well. Metabolic and hormonal derangements in gestational diabetes mellitus (GDM) affect feto-placental angiogenesis and vascular growth. Here we hypothesized that GDM alters the trophoblast secretome, which will modulate the paracrine regulation of feto-placental angiogenesis...
April 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
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