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Trophoblastic tumor

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https://www.readbyqxmd.com/read/28614227/case-report-of-pulmonary-epithelial-trophoblastic-tumor-in-a-young-female-patient
#1
Lijun Jiang, Hongfei Xu, Yuan Lu, Weidong Li, Chengfei Zheng
INTRODUCTION: An epithelial trophoblastic tumor (ETT) is a kind of rare trophoblastic tumor that may have the correlation with a prior gestational event. Especially, the one that appears in the lung is extremely rare. CASE SUMMARY: Here, we present a 24-year-old female patient with the chief complain of vaginal bleeding for more than 1 month, who was found to have a large mass (7.5 × 4.5 cm) in the right lower lobe, and it was finally confirmed as lung ETT by postoperative pathology after a successful radical resection of the pulmonary lobe...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28592902/ggnbp2-is-necessary-for-testis-morphology-and-sperm-development
#2
Anqi Chen, Jixi Li, Lesheng Song, Chaoneng Ji, Marion Böing, Jinzhong Chen, Beate Brand-Saberi
Gametogenetin Binding Protein 2 (GGNBP2) was identified as a tumor suppressor and verified as such by several studies. GGNBP2 has also been reported to be essential for pregnancy maintenance via regulation of trophoblast stem cells. Gametogenetin (GGN) is a testicular germ cell-specific gene expressed in adult testes. As a potential GGN1-interacting protein, the role of GGNBP2 in spermatogenesis has not yet been clarified. We generated heterozygous GGNBP2 knockout mice and bred them by intercrossing. We found that among the offspring, homozygous GGNBP2 knockout (KO) mice were present in severely reduced numbers...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28590345/two-cases-of-epithelioid-trophoblastic-tumors-in-postmenopausal-women
#3
Adriano Rodríguez-Trujillo, María José Martínez-Serrano, Adela Saco, Aureli Torné
OBJECTIVE: Epithelioid trophoblastic tumor is a rare gestational trophoblastic neoplasm usually presenting in women of reproductive age, with a history of a prior gestational event. Its presentation in postmenopausal women is extremely rare. Immunohistochemical staining is a helpful aid to distinguish epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. Correct diagnosis is crucial for clinical management that can vary according to the type of gestational trophoblastic neoplasm...
June 5, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28587570/effect-of-lactobacillus-rhamnosus-gr-1-supernatant-on-cytokine-and-chemokine-output-from-human-amnion-cells-treated-with-lipoteichoic-acid-and-lipopolysaccharide
#4
Rebecca J E Koscik, Gregor Reid, Sung O Kim, Wei Li, John R G Challis, Alan D Bocking
Preterm birth occurs in 9% to 13% of all human pregnancies and accounts for 80% of all neonatal morbidities and mortalities. Approximately 40% of all preterm births are idiopathic and about half are associated with infection and/or an activated inflammatory process. Further to studies showing anti-inflammatory effects of supernatant from the probiotic Lactobacillus rhamnosus GR-1 (GR-1), we tested its ability to modulate cytokine and chemokine production from amnion cells in response to stimulation by bacterial wall components, lipopolysaccharide (LPS), and lipoteichoic acid (LTA)...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28582346/endometrial-carcinoma-with-trophoblastic-components-clinicopathologic-analysis-of-a-rare-entity
#5
Kojo R Rawish, Natalia Buza, Wenxin Zheng, Oluwole Fadare
Somatic endometrial carcinomas with trophoblastic components have only rarely been described. To better characterize this distinctive combination of histotypes, we report herein 4 new cases, representing the largest cohort reported thus far, and review previously reported cases. The 4 new patients ranged in age from 61 to 77 yr (mean, 68 yr). The first patient had a grade 2 endometrioid carcinoma, surgical International Federation of Gynecology and Obstetrics stage IA, that recurred 5 months later at the vaginal apex with purely choriocarcinoma elements, suggestive of unsampled trophoblastic areas in the uterus...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28567335/rare-presentation-of-metastatic-cystic-trophoblastic-tumor-in-a%C3%A2-patient-without-prior-chemotherapy
#6
Michael L Wang, Jonathan B McHugh, Alon Z Weizer, Todd M Morgan, Arul M Chinnaiyan, Andrew P Sciallis, Amir Lagstein, Daniel E Spratt, Rohit Mehra
Cystic trophoblastic tumor (CTT) is a rare testicular germ cell tumor (GCT) predominantly seen in post-chemotherapy patients. It is prognostically similar to teratoma and requires no additional chemotherapy in the absence of a nonteratomatous GCT component. We report a case of metastatic CTT in a patient with primary testicular teratoma without prior chemotherapy. Retroperitoneal lymph node metastases contained teratoma, embryonal carcinoma, and CTT. The CTT was β-hCG positive and SALL4 negative by immunohistochemistry (IHC)...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28548328/epithelioid-trophoblastic-tumor-of-the-uterus-a-case-report-with-radiologic-pathologic-correlation
#7
Ayumi Ohya, Kayoko Higuchi, Hisashi Shimojo, Yasunari Fujinaga, Masumi Kadoya, Shigeki Shiohara
Herein, we report a rare case of an epithelioid trophoblastic tumor of the uterus with radiologic-pathologic correlation in a 56-year-old postmenopausal woman. On T2-weighted magnetic resonance (MR) imaging, the tumor appeared as a hypointense irregular mass compared with the surrounding myometrium of the uterine corpus and encircled the cavity of the lower uterine segment. On dynamic contrast-enhanced MR images, the tumor appeared as a hypovascular mass and an inhomogeneously hyperintense mass in the delayed phase...
May 26, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28546716/complete-molar-pregnancy-in-postmenopausal-woman
#8
Ahmed Samy El-Agwany, Helmy Abdelsattar Rady, Hassan Mansour Hegab
Gestational trophoblastic disease spectrum ranges from benign hydatidiform mole to trophoblastic malignancy (placental site trophoblastic tumor and choriocarcinoma). Benign gestational trophoblastic disease occurs in women of reproductive age and is extremely rare in postmenopausal women. We describe a case of complete vesicular mole in a 55-year-old postmenopausal woman complaining of postmenopausal bleeding. To our knowledge, our case represents one of the rare descriptions in the world literature of a benign complete hydatidiform mole in a postmenopausal woman...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28493802/placental-imaging-normal-appearance-with-review-of-pathologic-findings
#9
Shaimaa Fadl, Mariam Moshiri, Corinne L Fligner, Douglas S Katz, Manjiri Dighe
The placenta plays a crucial role throughout pregnancy, and its importance may be overlooked during routine antenatal imaging evaluation. Detailed systematic assessment of the placenta at ultrasonography (US), the standard imaging examination during pregnancy, is important. Familiarity with the normal and abnormal imaging appearance of the placenta along with the multimodality and methodical approach for evaluation of its related abnormalities is necessary, so that radiologists can alert clinicians regarding appropriate prompt management decisions...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28491173/radiographically-occult-pulmonary-metastases-from-gestational-trophoblastic-neoplasia
#10
Tina Hong, Edward Hills, Maria Del Pilar Aguinaga
Gestational trophoblastic neoplasia (GTN) is a spectrum of diseases including partial and complete hydatidiform moles, placental site trophoblastic tumor, and choriocarcinoma. One of the most important considerations is recognition of the possibility of GTN after molar pregnancy or even normal pregnancy. It is common practice to use chest x-ray for the detection of pulmonary metastasis. Computed tomography imaging of the lungs is ordered if lung lesions are noted on chest x-rays. However, understanding the limitations of chest x-rays is important for detecting smaller pulmonary lesions...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28481180/trophoblast-glycoprotein-tpgb-5t4-in-human-placenta-expression-regulation-and-presence-in-extracellular-microvesicles-and-exosomes
#11
S M K Alam, S Jasti, S K Kshirsagar, D S Tannetta, R A Dragovic, C W Redman, I L Sargent, H C Hodes, T L Nauser, T Fortes, A M Filler, K Behan, D R Martin, T A Fields, B K Petroff, M G Petroff
BACKGROUND: Many parallels exist between growth and development of the placenta and that of cancer. One parallel is shared expression of antigens that may have functional importance and may be recognized by the immune system. Here, we characterize expression and regulation of one such antigen, Trophoblast glycoprotein (TPGB; also called 5T4), in the placenta across gestation, in placentas of preeclamptic (PE) pregnancies, and in purified microvesicles and exosomes. METHODS: Trophoblast glycoprotein expression was analyzed by real-time reverse transcription-polymerase chain reaction (RT-PCR), Western blot, and immunohistochemistry...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28474163/-germ-cell-and-sex-cord-stromal-tumors-of-the-testis-who-classification-2016
#12
G Mikuz
Earlier revisions of the WHO classification of testicular tumors, which was originally published in 1977, contained only minor additions. In the WHO 2016 classification, in contrast, germ cell tumors are split into two major groups based on their distinct pathohistogenesis, i. e., those which derive from an in situ forerunner lesion and those which do not. The latter category includes prepubertal yolk sac tumors and teratomas, as well as spermatocytic seminoma. The classification of yolk sac tumors and teratomas as arising before or after puberty is also of prognostic value...
May 4, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28473205/salvage-chemotherapy-for-gestational-trophoblastic-neoplasia-utility-or-futility
#13
Kathleen G Essel, Amanda Bruegl, David M Gershenson, Lois M Ramondetta, R Wendel Naumann, Jubilee Brown
OBJECTIVE: To determine the efficacy of chemotherapy after failed initial treatment in patients with high risk gestational trophoblastic neoplasia (GTN). METHODS: We performed a retrospective IRB-approved chart review of all patients with GTN seen at a single institution from 1985 to 2015, including all patients who failed initial treatment. We summarized clinical characteristics with descriptive statistics and estimated progression-free survival (PFS) and overall survival (OS) with the Kaplan-Meier method...
May 2, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28467908/the-rodent-specific-microrna-cluster-within-the-sfmbt2-gene-is-imprinted-and-essential-for-placental-development
#14
Kimiko Inoue, Michiko Hirose, Hiroki Inoue, Yuki Hatanaka, Arata Honda, Ayumi Hasegawa, Keiji Mochida, Atsuo Ogura
MicroRNAs (miRNAs) represent small noncoding RNAs that are involved in physiological and developmental processes by posttranscriptionally inhibiting gene expression. One of the largest miRNA clusters in mice is located in intron 10 of the Sfmbt2 gene, containing 72 miRNA precursor sequences. In this study, we generated mice lacking the entire Sfmbt2 miRNA cluster to elucidate its functions during development. The Sfmbt2 miRNAs were expressed predominantly from the paternal allele in the placenta, as is the host Sfmbt2 gene...
May 2, 2017: Cell Reports
https://www.readbyqxmd.com/read/28462491/in-vitro-evaluation-of-combination-of-egcg-and-erlotinib-with-classical-chemotherapeutics-on-jar-cells
#15
Elçin Telli, Hatice Genç, Burcugül Altuğ Tasa, S Sinan Özalp, A Tansu Koparal
Gestational Trophoblastic Neoplasia (GTN) is a term used for a group of malignant gynecological tumors including choriocarcinoma. Low-risk neoplasias can be cured using single agents Methotrexate (MTX) and actinomycin-D (ACD), but in certain cases, decreased responsiveness and serious side effects occur. Therefore, researchers have been attempting to find new treatment modalities. One of the most popular way for increasing cancer patient survival rates is supporting treatment with adjuvant molecules or chemosensitizers...
May 1, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28459944/can-the-figo-2000-scoring-system-for-gestational-trophoblastic-neoplasia-gtn-be-simplified-a-new-retrospective-analysis-from-a-nationwide-data-set
#16
Y K Eysbouts, P B Ottevanger, L F A G Massuger, J IntHout, D Short, R Harvey, B Kaur, N J Sebire, N Sarwar, F C G J Sweep, M J Seckl
Background: Worldwide introduction of the FIGO 2000 scoring system has provided an effective means to stratify patients with gestational trophoblastic neoplasia (GTN) to single- or multi-agent chemotherapy. However, the system is quite elaborate with an extensive set of risk factors. In this study, we re-evaluate all prognostic risk factors involved in the FIGO 2000 scoring system and examine if simplification is feasible. Patients and methods: Between January 2003 and December 2012, 813 patients diagnosed with GTN were identified at the Trophoblastic Disease Centre in London and scored using the FIGO 2000...
April 28, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28454693/cytogenetic-features-of-human-trophoblast-cell-lines-swan-71-and-3a-sube
#17
Jill L Reiter, Holli M Drendel, Sujata Chakraborty, Megan M Schellinger, Men-Jean Lee, Gil Mor
Immortalization of primary cells with telomerase is thought to maintain normal phenotypic properties and avoid chromosomal abnormalities and other cancer-associated changes that occur following simian virus 40 tumor antigen (SV40 Tag) induced immortalization. However, we report that the human telomerase reverse transcriptase (hTERT)-immortalized SWAN-71 trophoblast cell line has a near pentaploid 103∼119,XXXX[cp20] karyotype. Additionally, DNA typing analysis indicated that SWAN-71 cells have acquired microsatellite instability...
April 2017: Placenta
https://www.readbyqxmd.com/read/28423362/trop2-promotes-proliferation-migration-and-metastasis-of-gallbladder-cancer-cells-by-regulating-pi3k-akt-pathway-and-inducing-emt
#18
Xinxing Li, Shifeng Teng, Yanyan Zhang, Weigang Zhang, Xianwen Zhang, Kai Xu, Houshan Yao, Jun Yao, Haolu Wang, Xiaowen Liang, Zhiqian Hu
The human trophoblast cell surface antigen 2 (TROP2) is overexpressed in many cancers. However, its effect on proliferation, migration and metastasis of gallbladder cancer remains unclear. In this study, we found that TROP2 was highly expressed in gallbladder cancer. Overexpression of TROP2 was associated with poor prognosis. Knockdown of TROP2 in gallbladder cancer cell lines strongly inhibited the cell proliferation, clone formation, invasion and migration in vitro, while TROP2 overexpression had opposite effects...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422548/epidemiological-profile-and-treatment-outcomes-in-young-adults-19-29-years-of-age-treated-for-cancer-in-a-tertiary-hospital-in-s%C3%A3-o-paulo-brazil
#19
Victor Hugo Fonseca de Jesus, Taynan Nunes Ribeiro, Ludmilla T Domingos Chinen, Vanessa Alves, Maria Paula Curado, Marcello Ferretti Fanelli
BACKGROUND: Worldwide, the incidence of cancer in young adults (20-39 years) is increasing, and represents an important cause of mortality in this age group. A retrospective study was undertaken to provide information that may lead to improved treatment outcomes. METHODS: Epidemiological, clinicopathological, treatment, and survival information were retrieved from the electronic database registry of a tertiary referral hospital in São Paulo, Brazil for patients 19-29 years of age diagnosed with cancer between January 2007 and December 2012...
June 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28413543/primary-intracranial-choriocarcinoma-presenting-as-a-ring-enhancing-lesion-a-case-report-and-review-of-literature
#20
Mayur Sharma, Vernon Velho, Rachana Binayake, Chandranath Tiwari
We report here a rare case of primary intracranial choriocarcinoma without evidence of tumor elsewhere, presenting as a ring-enhancing lesion managed successfully in our institute (Grant Medical College and Sir J. J. Group of Hospitals, Mumbai, Maharashtra, India). A 22-year-old, right-handed housewife presented with complaints of headache, vomiting, generalized tonic-clonic seizures, and right upper limb weakness of short duration. On neurological examination, the patient was conscious, cooperative, well-oriented in time, place, and person...
January 2017: Asian Journal of Neurosurgery
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