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https://www.readbyqxmd.com/read/28097431/placental-dapk1-and-autophagy-marker-lc3b-ii-are-dysregulated-by-tnf-%C3%AE-in-a-gestational-age-dependent-manner
#1
Andreas Prokesch, Astrid Blaschitz, Tamara Bauer, Gerit Moser, Ursula Hiden, Julianna Zadora, Ralf Dechend, Florian Herse, Martin Gauster
Autophagy, a cell-survival process responsible for degradation of protein aggregates and damaged organelles, is increasingly recognized as another mechanism essential for human placentation. A substantial body of experiments suggests inflammation and oxidative stress as the underlying stimuli for altered placental autophagy, giving rise to placenta dysfunction and pregnancy pathologies. Here, the hypothesis is tested whether or not pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α are able to influence the expression profile of autophagy genes in human first-trimester villous placenta...
January 17, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28087411/aspirin-prevents-tnf-%C3%AE-induced-endothelial-cell-dysfunction-by-regulating-the-nf-%C3%AE%C2%BAb-dependent-mir-155-enos-pathway-role-of-a-mir-155-enos-axis-in-preeclampsia
#2
Joohwan Kim, Kyu-Sun Lee, Ji-Hee Kim, Dong-Keon Lee, Minsik Park, Seunghwan Choi, Wonjin Park, Suji Kim, Yoon Kyoung Choi, Jong Yun Hwang, Jongseon Choe, Moo-Ho Won, Dooil Jeoung, Hansoo Lee, Sungwoo Ryoo, Kwon-Soo Ha, Young-Guen Kwon, Young-Myeong Kim
Preeclampsia is an inflammatory disease with endothelial cell dysfunction that occurs via decreased endothelial nitric oxide synthase/nitric oxide (eNOS/NO) activity. Aspirin reduces the incidence of hypertensive pregnancy complications. However, the underlying mechanism has not been clearly explained. Here, we found that tumor necrosis factor (TNF)-α, microRNA (miR)-155, and eNOS levels as well as endothelial redox phenotype were differentially regulated in preeclamptic patients, implying the involvement of TNF-α- and redox signal-mediated miR-155 biogenesis and eNOS downregulation in the pathogenesis of preeclampsia...
January 11, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28079767/primary-gastric-choriocarcinoma-presenting-as-a-pregnancy-of-unknown-location
#3
Alyssa Larish, Amanika Kumar, Sarah Kerr, Carrie Langstraat
BACKGROUND: Pregnancy of unknown location presents a diagnostic challenge, in rare occasions leading to the diagnosis of malignancy. We describe a case of β-hCG-secreting nongestational primary gastric choriocarcinoma presenting as a pregnancy of unknown location. CASE: A 37-year-old woman, gravida 4 para 3013, presented with several days of vaginal bleeding and rising β-hCG level without ultrasound localization of pregnancy. The diagnosis of pregnancy of unknown location was made and methotrexate administered at a β-hCG level of 7,779 milli-international units/mL...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28060956/technical-insights-into-highly-sensitive-isolation-and-molecular-characterization-of-fixed-and-live-circulating-tumor-cells-for-early-detection-of-tumor-invasion
#4
Sophie Laget, Lucile Broncy, Katia Hormigos, Dalia M Dhingra, Fatima BenMohamed, Thierry Capiod, Magne Osteras, Laurent Farinelli, Stephen Jackson, Patrizia Paterlini-Bréchot
Circulating Tumor Cells (CTC) and Circulating Tumor Microemboli (CTM) are Circulating Rare Cells (CRC) which herald tumor invasion and are expected to provide an opportunity to improve the management of cancer patients. An unsolved technical issue in the CTC field is how to obtain highly sensitive and unbiased collection of these fragile and heterogeneous cells, in both live and fixed form, for their molecular study when they are extremely rare, particularly at the beginning of the invasion process. We report on a new protocol to enrich from blood live CTC using ISET® (Isolation by SizE of Tumor/Trophoblastic Cells), an open system originally developed for marker-independent isolation of fixed tumor cells...
2017: PloS One
https://www.readbyqxmd.com/read/28060141/pd-l1-expression-in-premalignant-and-malignant-trophoblasts-from-gestational-trophoblastic-diseases-is-ubiquitous-and-independent-of-clinical-outcomes
#5
Pierre-Adrien Bolze, Sophie Patrier, Jérôme Massardier, Touria Hajri, Fatima Abbas, Anne Marie Schott, Fabienne Allias, Mojgan Devouassoux-Shisheboran, Gilles Freyer, François Golfier, Benoît You
OBJECTIVE: Recently reported expression of programmed cell death 1 ligand 1 (PD-L1) in gestational trophoblastic diseases (GTDs) suggests that the immune tolerance of pregnancy might be hijacked during neoplastic process. We assessed PD-L1 protein expression in premalignant and malignant GTD lesions and analyzed associations with disease severity and chemotherapy outcomes. METHODS: We included 83 GTD whole-tissue sections from 76 patients in different treatment settings...
January 4, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28054346/optimized-logic-rules-reveal-ifn-%C3%AE-induced-modes-regulated-by-histone-deacetylases-and-protein-tyrosine-phosphatases
#6
Daniel Van Twisk, Shawn P Murphy, Juilee Thakar
The pro-inflammatory cytokine interferon-γ (IFN-γ) is critical for activating innate and adaptive immunity against tumors and intracellular pathogens. IFN-γ is secreted at the fetal-maternal interface in pregnant women and mice. The outer layer of the placenta in contact with maternal blood is composed of semi-allogeneic trophoblast cells, which constitute the fetal component of the fetal-maternal interface. The simultaneous presence of pro-inflammatory IFN-γ and trophoblast cells at the fetal-maternal interface appears to represent an immunological paradox, for trophoblastic responses to IFN-γ could potentially lead to activation of maternal immunity and subsequent attack of the placenta...
January 5, 2017: Immunology
https://www.readbyqxmd.com/read/28012129/expression-of-cd24-and-siglec-10-in-first-trimester-placenta-implications-for-immune-tolerance-at-the-fetal-maternal-interface
#7
Marei Sammar, Monika Siwetz, Hamutal Meiri, Viktor Fleming, Peter Altevogt, Berthold Huppertz
During pregnancy, the fetal-maternal interface establishes immune tolerance between the fetus and the mother. CD24, a mucin-like glycoprotein expressed at the surface of hematopoietic cells and diverse tumor cells, is known to interact with the sialic acid-binding immunoglobulin-type lectins (Siglecs). This interaction was assessed as a candidate complex for the immune suppression response in the placenta. CD24 was affinity purified from term placenta and characterized by SDS-PAGE, Western blot and ELISA. Binding of recombinant Siglecs to placental CD24 was evaluated by ELISA...
December 23, 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/27965933/colorectal-choriocarcinoma-in-a-patient-with-probable-lynch-syndrome
#8
Viktor H Koelzer, Karl Steuer, Ulrike Camenisch Gross, Dieter Zimmermann, Aino Paasinen-Sohns, Kirsten D Mertz, Gieri Cathomas
BACKGROUND: Personalized therapy of colorectal cancer is influenced by morphological, molecular, and host-related factors. Here, we report the comprehensive clinicopathological and molecular analysis of an extra-gestational colorectal choriocarcinoma in a patient with probable Lynch syndrome. CASE PRESENTATION: A 61-year-old female with history of gastric cancer at age 36 presented with a transmurally invasive tumor of the right hemicolon and liver metastasis. A right hemicolectomy was performed...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27902976/centrosome-clustering-in-the-development-of-bovine-binucleate-trophoblast-giant-cells
#9
Karl Klisch, Elisabeth M Schraner, Alois Boos
Binucleate trophoblast giant cells (BNC) are the characteristic feature of the ruminant placenta. During their development, BNC pass through 2 acytokinetic mitoses and become binucleate with 2 tetraploid nuclei. In this study, we investigate the number and location of centrosomes in bovine BNC. Centrosomes typically consist of 2 centrioles surrounded by electron-dense pericentriolar material. Duplication of centrosomes is tightly linked to the cell cycle, which ensures that the number of centrosomes remains constant in proliferating diploid cells...
December 1, 2016: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/27899973/expression-patterns-of-maspin-and-mutant-p53-are-associated-with-the-development-of-gestational-trophoblastic-neoplasia
#10
Pengming Sun, Qibin Wu, Guanyu Ruan, Xiu Zheng, Yiyi Song, Jianfan Zhun, Lixiang Wu, Walter H Gotlieb
Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal proliferation of trophoblastic cells. GTDs encompass hydatidiform moles (HMs) and gestational trophoblastic neoplasia (GTN). GTNs are a group of malignant diseases that require chemotherapy, or more aggressive treatment. There is a requirement for more tumor markers to predict the development of GTN from HMs. The current study evaluated the expression of maspin and tumor protein p53 (p53) in GTD, and their role in predicting the development of GTN...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27871470/the-function-of-mir-519d-in-cell-migration-invasion-and-proliferation-suggests-a-role-in-early-placentation
#11
REVIEW
Lan Xie, Yoel Sadovsky
The processes of proliferation, migration, and invasion of extravillous trophoblasts are critical for placental implantation and early development, and directly influence pregnancy outcome. Dysregulation of these processes has been associated with placental dysfunction, implicated in clinical conditions such as preeclampsia and placental accreta. Among diverse microRNA (miRNA) species that are expressed in placental trophoblasts, members of the chromosome 19 miRNA cluster (C19MC) stand out in their nearly exclusive expression in the placenta...
December 2016: Placenta
https://www.readbyqxmd.com/read/27871466/autophagy-protects-against-oxidized-low-density-lipoprotein-mediated-inflammation-associated-with-preeclampsia
#12
Yan Zhang, Xiaoyu Hu, Guoqiang Gao, Yufang Wang, Pingping Chen, Yuanhua Ye
INTRODUCTION: Inflammatory responses play an important role in the pathogenesis of preeclampsia. Recently, the anti-inflammatory role played by autophagy has drawn increasing attention. Our aim was to investigate variations in autophagy in preeclampsia and protection against oxidized low-density lipoprotein (oxLDL)-mediated inflammation by autophagy. METHODS: We used immunohistochemistry, immunofluorescence, quantitative real-time PCR, and western blotting to analyze the expression of autophagy proteins (beclin-1 and LC3II/LC3I) in preeclampsia placentas and in JEG-3 cells treated with oxLDL and rapamycin...
December 2016: Placenta
https://www.readbyqxmd.com/read/27864359/endothelin-1-down-regulates-matrix-metalloproteinase-14-and-15-expression-in-human-first-trimester-trophoblasts-via-endothelin-receptor-type-b
#13
Alejandro Majali-Martinez, Philipp Velicky, Jürgen Pollheimer, Martin Knöfler, Hong Wa Yung, Graham J Burton, Nassim Ghaffari Tabrizi-Wizsy, Uwe Lang, Ursula Hiden, Gernot Desoye, Martina Dieber-Rotheneder
STUDY QUESTION: Does endothelin-1 (ET-1) regulate matrix metalloproteinase (MMP) 14 and 15 production and invasion of human first trimester trophoblasts? SUMMARY ANSWER: ET-1 in pathophysiological concentrations down-regulates MMP14 and MMP15 expression via endothelin receptor (ETR) type B and decreases trophoblast migration and invasion. WHAT IS KNOWN ALREADY: MMP14 and MMP15 are involved in trophoblast invasion. Impairment of invasion has been linked to pregnancy complications such as pre-eclampsia (PE)...
January 2017: Human Reproduction
https://www.readbyqxmd.com/read/27835686/clinical-outcome-in-singleton-and-multiple-pregnancies-with-placental-chorangioma
#14
Meeli Sirotkina, Konstantinos Douroudis, Nikos Papadogiannakis, Magnus Westgren
INTRODUCTION: Chorangiomas (CAs) are the most common non-trophoblastic tumor-like-lesions of the placenta. Although the clinical significance of small CAs is unknown, the large lesions are often associated with maternal and fetal complications. The aim of our study was to assess the maternal clinical characteristics and neonatal outcome in singleton and multiple pregnancies with placental CA. MATERIALS AND METHODS: Among 15742 selected placentas 170 CAs were diagnosed...
2016: PloS One
https://www.readbyqxmd.com/read/27825375/binding-of-galectin-1-to-breast-cancer-cells-mcf7-induces-apoptosis-and-inhibition-of-proliferation-in-vitro-in-a-2d-and-3d-cell-culture-model
#15
Pamina Geiger, Barbara Mayer, Irmi Wiest, Sandra Schulze, Udo Jeschke, Tobias Weissenbacher
BACKGROUND: Galectin-1 (gal-1) belongs to the family of β-galactoside-binding proteins which primarily recognizes the Galβ1-4GlcNAc sequences of oligosaccharides associated with several cell surface glycoconjugates. The lectin recognizes correspondent glycoepitopes on human breast cancer cells. Galectin-1 is expressed both in normal and malignant tissues. Lymphatic organs naturally possessing high rates of apoptotic cells, express high levels of Galectin-1. Furthermore galectin-1 can initiate T cell apoptosis...
November 8, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27819410/comparing-and-evaluating-the-efficacy-of-methotrexate-and-actinomycin-d-as-first-line-single-chemotherapy-agents-in-low-risk-gestational-trophoblastic-disease
#16
Young Jae Lee, Jeong Yeol Park, Dae Yeon Kim, Dae Shik Suh, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam
OBJECTIVE: The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy agents included methotrexate (MTX) and actinomycin D (ACT-D). METHODS: We conducted a retrospective study of 126 patients with GTD who were treated between 2000 and 2013. A total of 71 patients with LR GTD were treated with MTX (8-day regimen or weekly regimen, n=53) or ACT-D (bi-weekly pulsed regimen or 5-day regimen, n=18)...
October 7, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27793609/primary-choriocarcinoma-of-the-bladder-a-case-report-and-review-of-literature
#17
REVIEW
M Francesca Monn, Kaitlin R Jaqua, Richard Bihrle, Liang Cheng
Primary choriocarcinoma of the urinary bladder is a rare entity, and should be distinguished from urothelial carcinoma with trophoblastic differentiation. The leading treatment modalities include surgical extirpation, chemotherapy, and radiation; however, survival remains poor. Herein we describe a rare case of choriocarcinoma of the bladder in a man who presented for evaluation with hematuria and subsequently underwent radical cystectomy with urinary diversion. Diagnosis of extragonadal germ cell tumor was confirmed using fluorescence in situ hybridization identification of isochromosome 12p...
September 7, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27789086/placental-site-trophoblastic-tumors-and-epithelioid-trophoblastic-tumors-biology-natural-history-and-treatment-modalities
#18
REVIEW
Neil S Horowitz, Donald P Goldstein, Ross S Berkowitz
Placental site (PSTT) and epithelioid trophoblastic tumor (ETT) are rare types of gestational trophoblastic neoplasia (GTN) that arise from intermediate trophoblast. Given that this cell of origin is different from other forms of GTN, it is not surprising that the clinical presentation, tumor marker profile, and treatment paradigm for PSTT and ETT are quite different as well. The mainstay for therapy for stage I PSTT and ETT is hysterectomy with adjuvant chemotherapy reserved for those presenting greater than four years from the antecedent pregnancy...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/27774931/-c1q-and-tumor-necrosis-factor-related-protein-4-ctrp4-suppresses-caspase-1-il-1%C3%AE-inflammatory-pathway-in-trophoblasts-of-rat-models-with-preeclampsia
#19
Lili Duan, Zidong Liu, Lin Wang, Binfang Ma, Yibing Fan, Ying Xu, Fenfen Guo
Objective To explore the effect of C1q/tumor necrosis factor related protein 4 (CTRP4) on the placental trophoblasts of preeclampsia model rats. Methods Placental trophoblastic tissues were respectively collected from normal pregnant rats and model rats with preeclampsia, and then mRNA and protein expression levels of CTRP4, interleukin 1β (IL-1β), and caspase-1 were detected with quantitative real-time PCR (qRT-PCR) and Western blotting. Primary placental trophoblasts were isolated from normal pregnant rats and model rats; at different time points, flow cytometry was used to detect the number of PI(+)caspase-1(+) pyroptotic cells; and qRT-PCR and Western blotting were used to detect expression levels of IL-1β and caspase-1...
November 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27751424/diagnosis-and-management-of-a-rare-case-with-placental-site-trophoblastic-tumor
#20
Fu-Nan Cho, San-Nung Chen, Yu-Hsiang Chang, James R Carey
OBJECTIVE: Placental site trophoblastic tumor (PSTT) is rare and is characterized by a slow growth. The objective of this report is to present a case of PSTT associated with irregular vaginal spotting that occurred 1 year after normal vaginal delivery. CASE REPORT: This report provides interesting ultrasound, hysteroscopy, and histology findings of PSTT. It is difficult to make a clinical diagnosis of PSTT at an early stage. Without the use of immunohistochemical analysis, PSTT may evade histological detection...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
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