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https://www.readbyqxmd.com/read/28109056/impact-of-completeness-of-revascularization-in-complex-coronary-artery-disease-as-measured-with-the-syntax-revascularization-index-an-seeds-substudy
#1
Bo Xu, Nicolas Bettinger, Changdong Guan, Björn Redfors, Yuejin Yang, Bao Li, Yaling Han, Xi Su, Zuyi Yuan, Philippe Généreux
OBJECTIVES: We sought to study whether the level of completeness of revascularization as measured by the SYNTAX revascularization index (SRI) independently predicts adverse ischemic events after percutaneous coronary intervention (PCI) with second-generation drug-eluting stents (DES). BACKGROUND: The SRI quantifies the proportion of revascularized myocardium. It has been shown to independently predict adverse ischemic events after PCI with first-generation DES. METHODS: Among 1,900 patients enrolled in a registry to evaluate safety and effectiveness of everolimus drug-eluting stent (SEEDS) for coronary revascularization, the SRI was calculated and available for 1,851 patients...
January 21, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28108202/evaluation-of-coronary-flow-conditions-in-complex-coronary-artery-bifurcations-stenting-using-computational-fluid-dynamics-impact-of-final-proximal-optimization-technique-on-different-double-stent-techniques
#2
Gianluca Rigatelli, Marco Zuin, Fabio Dell'Avvocata, Dobrin Vassilev, Ramesh Daggubati, Thach Nguyen, Nguyen Van Viet Thang, Nicolas Foin
BACKGROUND/PURPOSE: Computational fluid dynamics (CFD) have been recently adopted in many fields of cardiovascular medicine and in interventional cardiology. Using CFD analysis we compared the use of different PCI procedures, with and without the utilization of a proximal optimization technique (POT), on a complex coronary artery bifurcation. METHODS/MATERIALS: For the analysis, we considered a hypothetic model of a left anterior descending artery-diagonal Medina 1,1,1 bifurcation type with a diameter of the proximal main branch (MB) and the side branch (SB) set at 3...
January 9, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28076449/long-term-follow-up-of-patients-after-percutaneous-coronary-intervention-with-everolimus-eluting-bioresorbable-vascular-scaffold
#3
Rafael Alexandre Meneguz-Moreno, José de Ribamar Costa, Freddy Antônio Britto Moscoso, Rodolfo Staico, Luiz Fernando Leite Tanajura, Marinella Patrizia Centemero, Auréa Jacob Chaves, Andrea Claudia Leão de Sousa Abizaid, Amanda Guerra de Moraes Rego E Sousa, Alexandre Antonio Cunha Abizaid
Background: Bioresorbable vascular scaffolds (BVS) were developed to improve the long-term results of percutaneous coronary intervention, restoring vasomotion. Objectives: To report very late follow-up of everolimus-eluting Absorb BVS (Abbott Vascular, Santa Clara, USA) in our center. Methods: Observational retrospective study, in a single Brazilian center, from August 2011 to October 2013, including 49 patients submitted to Absorb BVS implantation...
January 9, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28041756/trauma-induced-acute-myocardial-infarction-due-to-delayed-dissection-of-the-left-anterior-descending-coronary-artery
#4
Magdalena Wilczynska-Golonka, Pawel Rostoff, Aleksander Siniarski, Agnieszka Skrzypek, Andrzej Gackowski, Ewa Konduracka, Jadwiga Nessler
Acute myocardial infarction is a very rare, life-threatening complication of blunt chest trauma. A 27-year-old man with no previous medical history was admitted to the emergency department due to multiple trauma following a car accident. After 48h following the accident, the patient's condition rapidly deteriorated, with severe dyspnea at rest, tachycardia, and increasing chest pain. A 12-lead ECG showed a sinus tachycardia at 120bpm with significant ST-segment elevation in leads V1 to V5, pathologic Q wave in I, aVL, and QS complex in leads V1 to V4...
December 27, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28029214/long-term-outcomes-of-rotational-atherectomy-for-the-percutaneous-treatment-of-chronic-total-occlusions
#5
Lorenzo Azzalini, Rustem Dautov, Soledad Ojeda, Antonio Serra, Susanna Benincasa, Barbara Bellini, Francesco Giannini, Jorge Chavarría, Livia L Gheorghe, Manuel Pan, Mauro Carlino, Antonio Colombo, Stéphane Rinfret
OBJECTIVES: To study the long-term outcomes of rotational atherectomy (RA) for chronic total occlusion (CTO) percutaneous coronary intervention (PCI). BACKGROUND: There is little evidence on the incidence, procedural results and long-term outcomes of RA for CTO PCI. METHODS: This registry included data from consecutive patients undergoing CTO PCI at four specialized centers. Major adverse cardiac events (MACE: cardiac death, target-vessel myocardial infarction and ischemia-driven target-vessel revascularization) on follow-up were the primary endpoint...
December 28, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28026027/the-contemporary-value-of-peak-creatine-kinase-mb-after-st-segment-elevation-myocardial-infarction-above-other-clinical-and-angiographic-characteristics-in-predicting-infarct-size-left-ventricular-ejection-fraction-and-mortality
#6
Minke H T Hartman, Ruben N Eppinga, Pieter J J Vlaar, Chris P H Lexis, Erik Lipsic, Joost D E Haeck, Dirk J van Veldhuisen, Iwan C C van der Horst, Pim van der Harst
BACKGROUND: Complex multimarker approaches to predict outcome after ST-elevation myocardial infarction (STEMI) have only considered a single baseline sample, while neglecting easily obtainable peak creatine kinase and creatine kinase-MB (CK-MB) values during hospitalization. METHODS: We studied 476 patients undergoing primary percutaneous coronary intervention for STEMI and cardiac magnetic resonance imaging (CMRI) at 4-6 months after STEMI. We determined the association with cardiac biomarkers (peak CK-MB, peak troponin T, N-terminal pro-brain natriuretic peptide), clinical and angiographic characteristics with infarct size, and LVEF, followed by association with mortality in 1120 STEMI patients...
December 27, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/28012553/comparison-of-percutaneous-coronary-intervention-versus-coronary-artery-bypass-grafting-for-unprotected-left-main-coronary-artery-disease
#7
REVIEW
Syed Yaseen Naqvi, Jordan Klein, Tisa Saha, Daniel J McCormick, Sheldon Goldberg
Coronary artery bypass grafting (CABG) decreases mortality in patients with significant left main (LM) coronary artery disease and for years remained the therapy of choice for patients with this ominous lesion. Advances in percutaneous coronary intervention (PCI) have enabled it to become an alternative to CABG. The results of observational registries and randomized comparisons have shown the safety and efficacy of PCI in appropriately selected patients with low or intermediate angiographic risk scores. Furthermore, the use of physiological measures of flow limitation and the use of intracoronary imaging techniques has added benefit and improved outcomes...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28007963/interaction-of-p190a-rhogap-with-eif3a-and-other-translation-preinitiation-factors-suggests-a-role-in-protein-biosynthesis
#8
Prasanna Parasuraman, Peter Mulligan, James A Walker, Bihua Li, Myriam Boukhali, Wilhelm Haas, Andre Bernards
The negative regulator of Rho family GTPases, p190A RhoGAP, is one of six mammalian proteins harboring so-called FF motifs. To explore the function of these and other p190A segments, we identified interacting proteins by tandem mass spectrometry. Here we report that endogenous human p190A, but not its 50% identical p190B paralog, associates with all 13 eIF3 subunits and several other translational preinitiation factors. The interaction involves the first FF motif of p190A and the winged-helix/PCI domain of eIF3A, is enhanced by serum stimulation and reduced by phosphatase treatment...
December 22, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28007201/incidence-characteristics-predictors-and%C3%A2-outcomes-of-repeat-revascularization-after-percutaneous-coronary-intervention-and-coronary-artery-bypass-grafting-the-syntax-trial-at-5-years
#9
Catalina A Parasca, Stuart J Head, Milan Milojevic, Michael J Mack, Patrick W Serruys, Marie-Claude Morice, Friedrich W Mohr, Ted E Feldman, Antonio Colombo, Keith D Dawkins, David R Holmes, Pieter A Kappetein
OBJECTIVES: The study sought to determine the incidence, predictors, characteristics, and outcomes of repeat revascularization during 5-year follow-up of the SYNTAX (Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery) trial. BACKGROUND: Limited in-depth long-term data on repeat revascularization are available from randomized trials comparing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). METHODS: Incidence and timing of repeat revascularization and its relation to the long-term composite safety endpoint of death, stroke, and myocardial infarction were analyzed in the SYNTAX trial (n = 1,800) using Kaplan-Meier analysis...
December 26, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27988230/spontaneous-coronary-artery-dissection-still-a-lot-to-learn
#10
David Neves, Ângela Bento, Renato Fernandes, Lino Patrício, José Aguiar
Non-atherosclerotic spontaneous coronary artery dissection (SCAD) is an uncommon but probably underdetected pathological substrate for acute coronary syndrome. Clinical associations have been noted, like female gender and young age, but its pathophysiology is not yet fully understood. In this report we describe the case of a 50-year-old woman, without cardiovascular risk factors presenting with non-ST segment elevation myocardial infarction, in whom SCAD was diagnosed. Treatment was initially conservative but due to aggravation of the dissection she eventually underwent a complex percutaneous coronary intervention, requiring implantation of multiple stents, but with a good clinical outcome...
January 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27976540/a-helping-hand-guideliner-use-to-facilitate-stent-delivery
#11
Brian J Brown, J Dawn Abbott
The GuideLiner catheter system is a tool that can be used to increase procedural success in complex percutaneous coronary intervention. The safety profile of the device has improved with successive generations and with increased operator experience. Methods to utilize the GuideLiner safely and effectively are described in this article.
December 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27974670/the-syntax-score-does-not-predict-risk-of-adverse-events-in-patients-with-non-st-elevation-acute-coronary-syndrome-who-undergo-coronary-artery-bypass-graft-surgery
#12
Björn Redfors, Chun-Hui He, Tullio Palmerini, Adriano Caixeta, Gennaro Giustino, Girma Minalu Ayele, Ajay J Kirtane, Roxana Mehran, Gregg W Stone, Philippe Généreux
OBJECTIVES: We tested the ability of the SYNTAX score (SS) to predict 1-year adverse outcomes for patients with non-ST segment elevation acute coronary syndromes (NSTE-ACS) who undergo coronary artery bypass graft (CABG) surgery. BACKGROUND: The SS effectively risk stratifies patients who undergo percutaneous coronary intervention, but not patients with stable coronary disease who undergo CABG. METHODS: We calculated the SS for 457 patients with NSTE-ACS in the angiographic substudy of the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) trial who underwent CABG...
December 15, 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27974669/initial-experience-of-bioabsorbable-polymer-everolimus-eluting-synergy-stents-in-high-risk-patients-undergoing-complex-percutaneous-coronary-intervention-with-early-discontinuation-of-dual-antiplatelet-therapy
#13
Rebecca L Noad, Colm G Hanratty, Simon J Walsh
AIMS: As more elderly and co-morbid patients require percutaneous revascularization, 1 year of dual-antiplatelet therapy (DAPT) becomes concerning. Synergy stents (Boston Scientific) allow for early cessation of DAPT. This study assessed those in our unit who underwent percutaneous coronary intervention (PCI) with a Synergy stent to examine a minimum of 6 months of clinical outcomes after early discontinuation of DAPT. METHODS AND RESULTS: All non-trial patients in our unit who had PCI with a Synergy stent from August 2013 to February 2016 were retrospectively analyzed...
15, 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27974432/incidence-and-determinants-of-complications-in-rotational-atherectomy-insights-from-the-national-clinical-data-j-pci-registry
#14
Kenichi Sakakura, Taku Inohara, Shun Kohsaka, Tetsuya Amano, Shiro Uemura, Hideki Ishii, Kazushige Kadota, Masato Nakamura, Hiroshi Funayama, Hideo Fujita, Shin-Ichi Momomura
BACKGROUND: The usage of rotational atherectomy (RA) is growing in the current percutaneous coronary intervention (PCI) because of the expansion of PCI indication to more complex lesions. However, the complications after RA have been linked to procedure-related morbidity and mortality. The purpose of this study was to investigate the incidence and determinants of complications in RA using a large nationwide registration system in Japan (J-PCI). METHODS AND RESULTS: The primary composite outcome of this study was defined as the occurrence of in-hospital death, cardiac tamponade, and emergent surgery after RA...
November 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27970384/tct-213-efficacy-and-safety-of-long-versus-short-term-dual-antiplatelet-therapy-following-complex-percutaneous-coronary-intervention-with-drug-eluting-stents-a-collaborative-patient-level-pooled-analysis-of-randomized-controlled-trials
#15
Gennaro Giustino, Alaide Chieffo, Tullio Palmerini, Marco Valgimigli, Fausto Feres, Alexandre Abizaid, Ricardo Costa, Myeong-Ki Hong, Byeong-Keuk Kim, Yangsoo Jang, Hyo-Soo Kim, Kyung Woo Kw Park, Martine Gilard, Marie-Claude Morice, Fadi Sawaya, Gennaro Sardella, George Danias, Philippe Généreux, Bjorn Redfors, Martin Leon, Deepak Bhatt, Gregg Stone, Antonio Colombo
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970377/tct-205-incidence-and-clinical-outcomes-associated-with-dapt-discontinuation-in-complex-pci-patients-from-the-paris-registry
#16
Jaya Chandrasekhar, Usman Baber, Samantha Sartori, Melissa Aquino, Thomas Stuckey, Timothy Henry, David Moliterno, David Cohen, Philippe Gabriel Steg, Ioannis Iakovou, Jeffrey Bruckel, Stuart Pocock, Annapoorna Kini, Antonio Colombo, Alaide Chieffo, Bernhard Witzenbichler, Giora Weisz, George Dangas, C Michael Gibson, Roxana Mehran
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969798/tct-444-one-year-prognostic-utility-of-the-syntax-score-ii-in-complex-pci-with-biodegradable-polymer-drug-eluting-stents-a-panda-iii-analysis
#17
Changdong Guan, Bo Xu, Runlin Gao, Gregg Stone
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969662/tct-314-the-impact-of-chronic-kidney-disease-on-outcomes-following-percutaneous-coronary-interventions-versus-coronary-artery-bypass-grafting-in-patients-with-complex-coronary-artery-disease-5-year-follow-up-of-the-syntax-trial
#18
Milan Milojevic, Stuart Head, Michael Mack, Friedrich Mohr, Marie-Claude Morice, Keith Dawkins, David Holmes, Patrick Serruys, A Pieter Kappetein
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969629/tct-288-safety-and-efficacy-of-new-generation-drug-eluting-stents-in-women-undergoing-complex-percutaneous-coronary-intervention-from-the-women-in-innovation-and-drug-eluting-stents-win-des-collaborative-patient-level-pooled-analysis
#19
Gennaro Giustino, Usman Baber, Philippe Généreux, Gregg Stone, Martin Leon, George Dangas, Samantha Sartori, Melissa Aquino, Stephan Windecker, Patrick Serruys, Adnan Kastrati, William Wijns, Philippe Gabriel Steg, Giulio Stefanini, Marco Valgimigli, Takeshi Kimura, Clemens von Birgelen, Edoardo Camenzind, Soeren Galatius, Roxana Mehran
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27956440/acute-coronary-syndromes
#20
Tushar Kotecha, Roby D Rakhit
In the UK, there are over 80,000 admissions annually with acute coronary syndromes (ACS). Management of ST-elevation myocardial infarction (STEMI) involves primary percutaneous coronary intervention (PCI), which is delivered via dedicated heart attack centres. Non-ST elevation-ACS (NSTE-ACS) accounts for two-thirds of ACS presentations, affecting an older cohort of patients - often with more complex comorbidities. Initial management is with anti-thrombotic therapy with a view to PCI within 24 hours for the most acute cases and within 72 hours for all others...
December 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
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