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https://www.readbyqxmd.com/read/28073680/rationale-and-design-of-pemvitastart-an-open-label-randomized-trial-comparing-simultaneous-versus-standard-initiation-of-vitamin-b12-and-folate-supplementation-in-nonsquamous-non-small-cell-lung-cancer-patients-undergoing-first-line-pemetrexed-based-chemotherapy
#1
Milind Baldi, Digambar Behera, Jyotdeep Kaur, Rakesh Kapoor, Navneet Singh
Pemetrexed is the preferred chemotherapeutic drug for nonsquamous, non-small-cell lung cancer patients whenever the predictive molecular biomarkers for targeted therapy have either not been assessed or are absent. As per manufacturers' instructions, supplementation with folic acid (FA; folate) at a dose of 350 to 1000 μg daily should be started seven days before the first dose of pemetrexed-based chemotherapy and continued during therapy and for 21 days after therapy cessation. Vitamin B12 injections (1000 μg intramuscularly) should also be started one week before the first dose of chemotherapy...
December 2, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27998753/effects-of-intra-hippocampal-microinjection-of-vitamin-b12-on-the-orofacial-pain-and-memory-impairments-induced-by-scopolamine-and-orofacial-pain-in-rats
#2
Amir Erfanparast, Esmaeal Tamaddonfard, Shaghayegh Nemati
In the present study, we investigated the effects of microinjection of vitamin B12 into the hippocampus on the orofacial pain and memory impairments induced by scopolamine and orofacial pain. In ketamine-xylazine anesthetized rats, the right and left sides of the dorsal hippocampus (CA1) were implanted with two guide cannulas. Orofacial pain was induced by subcutaneous injection of formalin (1.5%, 50μl) into the right vibrissa pad, and the durations of face rubbing were recorded at 3-min blocks for 45min. Morris water maze (MWM) was used for evaluation of learning and memory...
December 18, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27920821/protective-effect-of-vitamin-c-vitamin-b12-and-omega-3-on-lead-induced-memory-impairment-in-rat
#3
Saeedeh Alsadat Moosavirad, Mohammad Rabbani, Mohammad Sharifzadeh, Ali Hosseini-Sharifabad
Lead belongs to the heavy metal group and is considered as an environmental contaminant. Acute or chronic contact to lead can change the physiological function of human organs. One of the most important disorders following the lead exposure is neurotoxicity. Lead neurotoxicity consists of the neurobehavioral disturbances like cognitive impairment. The aim of the current study is to evaluate the possible protective effect of vitamin C (Vit C), vitamin B12 (Vit B12), omega 3 (ω-3), or their combination on the lead-induced memory disorder...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27858373/vitamin-b12-administration-by-subcutaneous-catheter-device-in-a-cobalamin-a-cbla-patient
#4
E Maines, G Morandi, G Gugelmo, F Ion-Popa, N Campostrini, A Pasini, M Vincenzi, F Teofoli, M Camilot, A Bordugo
Cobalamin A deficiency (cblA) is an inherited disorder of intracellular cobalamin metabolism, caused by impaired 5'-deoxy-adenosylcobalamin (AdoCbl) synthesis. Hydroxocobalamin (OHCbl) is the cornerstone of cblA treatment because vitamin B12 may completely restore AdoCbl deficiency. Parenteral administration, intravenous, subcutaneous or intramuscular, is generally required to achieve effect. Daily injections represent a problem for the parents and the caregivers, and this may lead to poor compliance and scarce adherence to the long-term treatment...
November 18, 2016: JIMD Reports
https://www.readbyqxmd.com/read/27729749/ataxic-gait-following-total-gastrectomy-for-gastric-cancer
#5
Chang Ho Hwang, Dong Jin Park, Gyu Yeol Kim
A 58-year-old woman, who had undergone total gastrectomy for early gastric cancer 9 years previously, visited the outpatient clinic complaining of progressive difficulty in walking for 15 d. Laboratory examinations showed macrocytic anemia and a decreased serum vitamin B12 concentration and increased serum concentrations of folate, vitamin E and copper. Magnetic resonance imaging showed multifocal high signal intensities along the posterior column of the cervical and thoracic spinal cord. Treatment consisted of intramuscular injections of vitamin B12 for 7 d, which increased her serum level of vitamin B12 to normal...
October 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27649354/cobalt-induced-contact-urticaria-presenting-as-chronic-urticaria-due-to-intramuscular-vitamin-b12-injections
#6
Jordan Huber, Jason Ezra Hawkes, Douglas L Powell
No abstract text is available yet for this article.
September 2016: Dermatitis
https://www.readbyqxmd.com/read/27602354/oral-vitamin-b12-replacement-for-the-treatment-of-pernicious-anemia
#7
REVIEW
Catherine Qiu Hua Chan, Lian Leng Low, Kheng Hock Lee
Many patients with pernicious anemia are treated with lifelong intramuscular (IM) vitamin B12 replacement. As early as the 1950s, there were studies suggesting that oral vitamin B12 replacement may provide adequate absorption. Nevertheless, oral vitamin B12 replacement in patients with pernicious anemia remains uncommon in clinical practice. The objective of this review is to provide an update on the effectiveness of oral vitamin B12 for the treatment of pernicious anemia, the recommended dosage, and the required frequency of laboratory test and clinical monitoring...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27526683/supplements-of-vitamins-b9-and-b12-affect-hepatic-and-mammary-gland-gene-expression-profiles-in-lactating-dairy-cows
#8
Bazoumana Ouattara, Nathalie Bissonnette, Melissa Duplessis, Christiane L Girard
BACKGROUND: A combined supplement of vitamins B9 and B12 was reported to increase milk and milk component yields of dairy cows without effect on feed intake. The present study was undertaken to verify whether this supplementation positively modifies the pathways involved in milk and milk component synthesis. Thus, by studying the transcriptome activity in these tissues, the effect of supplements of both vitamins on the metabolism of both liver and mammary gland, was investigated. For this study, 24 multiparous Holstein dairy cows were assigned to 6 blocks of 4 animals each according to previous 305-day milk production...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27474730/effective-vitamin-b12-treatment-can-reduce-serum-antigastric-parietal-cell-antibody-titer-in-patients-with-oral-mucosal-disease
#9
Andy Sun, Julia Yu-Fong Chang, Yi-Ping Wang, Shih-Jung Cheng, Hsin-Ming Chen, Chun-Pin Chiang
BACKGROUND/PURPOSE: Patients with serum antigastric parietal cell antibody (GPCA) positivity may have vitamin B12 deficiency and some oral symptoms. This study assessed the changes of serum GPCA titer in GPCA-positive patients after effective vitamin B12 treatment. METHODS: Two hundred and ten GPCA-positive oral mucosal disease patients became oral symptom free (complete response) after 1.0-67.1 months of treatment with regular and continuous intramuscular injection of vitamin B12 once per week...
October 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27462097/homocysteine-lowering-for-stroke-prevention-unravelling-the-complexity-of-the-evidence
#10
J David Spence
Elevated levels of total homocysteine impair endothelial dysfunction and increase thrombosis. Homocysteine is causal in animal models, and in human studies, elevated total homocysteine is significantly associated with carotid atherosclerosis, lacunar infarction, and markedly increased risk of stroke in atrial fibrillation. Because two of the early large trials of B vitamin therapy (Vitamin Intervention for Stroke Prevention and the Norwegian Vitamin Study) did not show any reduction of stroke, and the Heart Outcomes Prevention Evaluation 2 trial was mistakenly interpreted as not showing a reduction of stroke (because the authors could not think of a biological difference between stroke and myocardial infarction), there has been widespread pessimism regarding treatment to lower total homocysteine for stroke prevention...
October 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27416488/hibiscus-sabdariffa-increases-hydroxocobalamin-oral-bioavailability-and-clinical-efficacy-in-vitamin-b12-deficiency-with-neurological-symptoms
#11
Zouhayr Souirti, Mouna Loukili, Imar D Soudy, Kaies Rtibi, Aslihan Özel, Nicolas Limas-Nzouzi, Seloua El Ouezzani, Bruno Eto
The aim of the study was to evaluate the bioavailability and clinical benefits of oral new formulation (HB12 ) of hydroxocobalamin (Hdrx) with Hibiscus sabdariffa (HS). First, in an observational study, a cohort of 30 vitamin B12 -deficient patients (vit B12 < 200 pg/mL) with neurological symptoms received oral fixed dose of Hdrx containing 15 mg Hdrx daily for 10 days followed by 15 mg monthly. Clinical benefits were evaluated on haematological and biochemical parameters, and neurological improvement at days 10 and 90 compared to day 0...
December 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27373094/-effect-and-mechanism-of-il-1%C3%AE-jnk-transduction-pathway-on-the-nasal-mucosa-remodeling-in-allergic-rhinitis-rats
#12
Xiao Gu, Qin Li, Yanlin Chen, Yanyi Ma, Yongdong Zhang, Chongwei Sun, Cuiping You
OBJECTIVE: To study the role of JNK (c-Jun N-terminal kinase) signal transduction pathway on the nasal mucosa remodeling in allergic rhinitis rats, to explore whether IL-1β participates the nasal mucosa remodeling in allergic rhinitis by JNK signal transduction pathway. METHOD: Totally 60 male Wistar rats (weighing about 200-250 g)were randomly divided into A (AR group) and B group (control group). The rats in A group were sensitized for inducing AR by intraperitoneal injection ovalbumin and Al(OH)₃...
February 2016: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/27355231/sublingual-vitamin-b12-compared-to-intramuscular-injection-in-patients-with-type-2-diabetes-treated-with-metformin-a-randomised-trial
#13
Amber Parry-Strong, Fali Langdana, Sylvan Haeusler, Mark Weatherall, Jeremy Krebs
UNLABELLED: MAIM: To compare a single 1mg intramuscular hydroxocobalamin injection with a 3-month course of 1mg/day sublingual methylcobalamin supplements on serum vitamin B12 concentrations in participants withtype 2 diabetes treated with metformin. METHOD: Participants on metformin treatment with vitamin B12 concentrations below 220pmol/L were recruited through hospital diabetes clinics and primary care practices. They were randomised to receive either the injection or sublingual treatment...
June 10, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27347032/clinical-study-of-shengxuening-tablet-combined-with-rhuepo-for-the-treatment-of-renal-anemia-of-maintenance-hemodialysis-patients
#14
Xin Cheng, Guojun Yu, Jiangping Hu, Xuefeng Xu, Fang Luo, Ping Shen, Guosheng Zhang, Ning Yang
The aim of the present study was to investigate the clinical effects of Shengxuening tablet (silkworm excrement) combined with recombinant human erythropoietin (rHuEPO) for the treatment of renal anemia of maintenance hemodialysis (MHD) patients. Seventy-two MHD patients with renal anemia were included in the study and randomly divided into the control (n=34) and observation (n=38) groups. Patients in the control group were treated by hypodermic injection of 100-150 U/(kg·w) rHuEPO and patients in the observation group were treated by rHuEPO + 1...
July 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27336853/plasma-aminothiols-status-and-inverse-correlation-of-total-homocysteine-with-b-vitamins-in-arsenic-exposed-population-of-west-bengal-india
#15
Ashit K Mukherjee, Sujoy K Manna, Sanjit K Roy, Manisha Chakraborty, Surajit Das, Jnan P Naskar
Chronic arsenic toxicity is a serious environmental health problem across the world. Bangladesh and India (particularly the state of West Bengal) are the worst affected countries with such problem. The present study reports plasma-aminothiols (p-aminothiols) like L-cysteine (L-Cys), cysteinyl glycine (Cys-gly), total homocysteine (t-Hcy) and glutathione (GSH) status, and the inverse relationship of t-Hcy with B-vitamins (B1, B6, B9 and B12) in arsenic exposed population of West Bengal, India. Reverse phase HPLC was used to measure p-aminothiols and serum B-vitamins in different arsenic exposed population...
September 18, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27247211/nitrous-oxide-misuse-and-vitamin-b12-deficiency
#16
Thomas H Massey, Trevor T Pickersgill, Kathryn J Peall
A 36-year-old man presented to hospital with a 5-week history of ascending limb paraesthesiae and balance difficulties. He had no medical or travel history of note, but admitted habitual nitrous oxide (N2O) inhalation. Neurological examination revealed a sensory ataxia with pseudoathetosis in the upper limbs and reduced vibration sensation to the hips bilaterally. Significant investigation results included a low serum vitamin B12 concentration, mild macrocytosis and raised serum homocysteine concentration. T2 MRI of the spinal cord demonstrated increased signal extending from C1 to T11 in keeping with a longitudinal myelitis...
May 31, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27146501/comparison-between-different-intramuscular-vitamin-b12-supplementation-regimes-a-retrospective-matched-cohort-study
#17
H J M Smelt, S Pouwels, M Said, K A Berghuis, A K Boer, J F Smulders
BACKGROUND: The incidence of vitamin B12 deficiency after bariatric surgery can range from 26 to 70 %. There is no consensus on optimal vitamin B12 supplementation in postbariatric patients. The objective of this study was to compare three different regimes. METHODS: In this retrospective matched cohort study, we included 63 patients with methylmalonic acid (MMA) levels ≥300 nmol/L. Group A (n = 21) received 6 intramuscular (im) vitamin B12 injections including a loading dose, group B (n = 21) received 3 im vitamin B12 injections without loading dose and group C (n = 21) received no im vitamin B12 injections...
May 5, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27101678/-role-of-p-jnk-and-p-c-jun-of-jnk-transduction-pathway-on-the-nasal-mucosa-remodeling-in-allergic-rhinitis-rats
#18
Qin Li, Yanlin Chen, Yanyi Ma, Yongdong Zhang, Chongwei Sun
OBJECTIVE: To study the role of P-JNK and P-c-Jun of JNK (c-Jun N-terminal kinase) on nasal mucosa remodeling in allergic rhinitis rats. METHOD: Sixty male Wistar rats (weighing about 200-250 g) were randomly divided into AR group (A group) and B group(control group). The rats in A group were sensitized for inducing AR by intraperitoneal injection of ovalbumin and Al(OH)₃. Rats in group A were randomized into A4, A8 and A12 group (each had 10 rats). Ovalbumin was dropped in each nasal cavity of every rat for 4,8,12 weeks, respectively...
December 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/26889605/randomized-placebo-controlled-trial-of-methyl-b12-for-children-with-autism
#19
Robert L Hendren, S Jill James, Felicia Widjaja, Brittany Lawton, Abram Rosenblatt, Stephen Bent
OBJECTIVE: Children with autism spectrum disorder (ASD) have been reported to have reduced ability to methylate DNA and elevated markers of oxidative stress. We sought to determine if methyl B12, a key metabolic cofactor for cellular methylation reactions and antioxidant defense, could improve symptoms of ASD. METHODS: A total of 57 children with ASD were randomly assigned to 8 weeks of treatment with methyl B12 (75 μg/kg) or saline placebo every 3 days in a subcutaneous injection...
November 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26887521/-clinical-efficacy-of-vitamin-support-in-lung-adenocarcinoma-patients-treated-with-pemetrexed-second-line-chemotherapy
#20
RANDOMIZED CONTROLLED TRIAL
Xiaoyuan Zeng, Chengzhi Zhou, Ming Ouyang, Yinyin Qin, Hongzhong Yang, Yiqiang Peng, Shenggang Liu
OBJECTIVE: To analyze the clinical efficacy and toxicity of vitamin support in lung adenocarcinoma patients treated with pemetrexed second-line chemotherapy. METHODS: Two hundred and eighty-three patients with stage 3/4 lung adenocarcinoma treated at our hospital from August 2010 to August 2013 were included in this study. The lung adenocarcinomas in all the 283 patients were confirmed by pathology or cytology, all were EGFR-negative, and all patients received pemetrexed second line chemotherapy...
November 2015: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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