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https://www.readbyqxmd.com/read/29925015/protein-configurational-states-guide-radical-rearrangement-catalysis-in-ethanolamine-ammonia-lyase
#1
Neslihan Ucuncuoglu, Kurt Warncke
The adenosylcobalamin- (coenzyme B12 ) dependent ethanolamine ammonia-lyase (EAL) plays a key role in aminoethanol metabolism, associated with microbiome homeostasis and Salmonella- and Escherichia coli-induced disease conditions in the human gut. To gain molecular insight into these processes toward development of potential therapeutic targets, reactions of the cryotrapped (S)-2-aminopropanol substrate radical EAL from Salmonella typhimurium are addressed over a temperature (T) range of 220-250 K by using T-step reaction initiation and time-resolved, full-spectrum electron paramagnetic resonance spectroscopy...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29915236/single-molecule-probing-of-the-conformational-homogeneity-of-the-abc-transporter-btucd
#2
Min Yang, Nurit Livnat Levanon, Burçin Acar, Burcu Aykac Fas, Gal Masrati, Jessica Rose, Nir Ben-Tal, Turkan Haliloglu, Yongfang Zhao, Oded Lewinson
ATP-binding cassette (ABC) transporters use the energy of ATP hydrolysis to move molecules through cellular membranes. They are directly linked to human diseases, cancer multidrug resistance, and bacterial virulence. Very little is known of the conformational dynamics of ABC transporters, especially at the single-molecule level. Here, we combine single-molecule spectroscopy and a novel molecular simulation approach to investigate the conformational dynamics of the ABC transporter BtuCD. We observe a single dominant population of molecules in each step of the transport cycle and tight coupling between conformational transitions and ligand binding...
July 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29913560/maternal-folic-acid-supplementation-with-vitamin-b-12-deficiency-during-pregnancy-and-lactation-affects-the-metabolic-health-of-adult-female-offspring-but-is-dependent-on-offspring-diet
#3
Amanda M Henderson, Daven C Tai, Rika E Aleliunas, Abeer M Aljaadi, Melissa B Glier, Eric E Xu, Joshua W Miller, C Bruce Verchere, Tim J Green, Angela M Devlin
Epidemiologic studies have reported relationships between maternal high folate and/or low B12 status during pregnancy and greater adiposity and insulin resistance in children. The goal of this study was to determine the effects of maternal folic acid supplementation (10 mg/kg diet), with (50 μg/kg diet) and without B12 , on adult, female offspring adiposity and glucose homeostasis. Female C57BL/6J mice were fed 1 of 3 diets from weaning and throughout breeding, pregnancy, and lactation: control (2 mg/kg diet folic acid, 50 μg/kg diet B12 ), supplemental folic acid with no B12 (SFA-B12 ), or supplemental folic acid with adequate B12 (SFA+B12 )...
April 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29912556/photolytic-properties-of-antivitamins-b-12
#4
Piotr Lodowski, Megan J Toda, Karolina Ciura, Maria Jaworska, Pawel M Kozlowski
Antivitamins B12 represent an important class of vitamin B12 analogues that have gained recent interest in several research areas. In particular, 4-ethylphenylcobalamin (EtPhCbl) and phenylethynylcobalamin (PhEtyCbl) exemplify two such antivitamins B12 which have been characterized structurally and chemically. From a spectroscopic point of view, EtPhCbl is photolabile with a very low quantum yield of photoproducts, while PhEtyCbl is incredibly photostable. Herein, DFT and TD-DFT computations are provided to explore the photolytic properties of these compounds to shed light on the electronic properties that are indicative of these differences...
June 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29867006/egg-consumption-in-infants-is-associated-with-longer-recumbent-length-and-greater-intake-of-several-nutrients-essential-in-growth-and-development
#5
Yanni Papanikolaou, Victor L Fulgoni
Nutrient intake during infancy is critical for healthy growth and development. The present study examined egg consumption and associations with nutrient intakes, markers of growth and weight-related measures in infants 6⁻24 months of age ( N = 561) compared to infant egg non-consumers ( N = 2129). Egg consumers were defined as those infants consuming eggs (i.e., with the exclusion of mixed dishes) during a 24-h dietary recall. Associations with nutrient intakes and markers of growth variables were evaluated using data from What We Eat in America, the dietary component of the National Health and Nutrition Examination Survey, 2001⁻2012...
June 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29847308/a-cross-sectional-study-of-nutritional-status-diet-and-dietary-restrictions-among-persons-with-an-ileostomy-or-colostomy
#6
Ana Lívia de Oliveira, Ana Paula Boroni Moreira, Michele Pereira Netto, Isabel Cristina Gonçalves Leite
Little is known about the nutritional status and dietary habits of persons with an intestinal stoma, and no specific dietary guidelines have been established. A cross-sectional study was conducted among patients of a Stoma Patient Health Care Service in Juiz de Fora, Brazil, to compare the nutritional status of persons with an ileostomy or colostomy and to evaluate which foods are avoided most frequently and why. Anthropometric measurements (weight, height, arm circumference, and triceps and subscapular skinfold thickness) and body fat were assessed...
May 2018: Ostomy/wound Management
https://www.readbyqxmd.com/read/29845181/novel-protein-lipid-composite-nanoparticles-with-an-inner-aqueous-compartment-as-delivery-systems-of-hydrophilic-nutraceutical-compounds
#7
Guangyu Liu, Weijuan Huang, Oksana Babii, Xiaoyu Gong, Zhigang Tian, Jingqi Yang, Yixiang Wang, René L Jacobs, Vine Donna, Afsaneh Lavasanifar, Lingyun Chen
Food protein and lipid based nanoparticles have attracted recent interest as a means of delivering nutraceuticals. Nanoparticle encapsulation of nutraceuticals faces challenges to overcome for it to be readily applied in the food industry, such as low encapsulation efficiency for hydrophilic compounds and poor stability once in the gastrointestinal tract. This research introduces a new protein-lipid composite nanoparticle with a three-layered structure (a barley protein layer, α-tocopherol layer and phospholipid layer) and an inner aqueous compartment to load hydrophilic nutraceuticals...
May 30, 2018: Nanoscale
https://www.readbyqxmd.com/read/29799204/ultrafast-x-ray-absorption-near-edge-structure-reveals-ballistic-excited-state-structural-dynamics
#8
Nicholas A Miller, Aniruddha Deb, Roberto Alonso-Mori, James M Glownia, Laura M Kiefer, Arkaprabha Konar, Lindsay B Michocki, Marcin Sikorski, Danielle L Sofferman, Sanghoon Song, Megan J Toda, Theodore E Wiley, Diling Zhu, Pawel M Kozlowski, Kevin J Kubarych, James E Penner-Hahn, Roseanne J Sension
Polarized ultrafast time-resolved X-ray absorption near edge structure (XANES) allows characterization of excited state dynamics following excitation. Excitation of vitamin B12 , cyanocobalamin (CNCbl), in the αβ-band at 550 nm and the γ-band at 365 nm was used to uniquely resolve axial and equatorial contributions to the excited state dynamics. The structural evolution of the excited molecule is best described by a coherent ballistic trajectory on the excited state potential energy surface. Prompt expansion of the Co cavity by ca...
May 25, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29766695/analysis-of-nutrition-and-nutritional-status-of-haemodialysis-patients
#9
Anna Bogacka, Anna Sobczak-Czynsz, Elżbieta Kucharska, Małgorzata Madaj, Katarzyna Stucka
Background: Chronic kidney disease (CKD) is a common disease of civilization where nutrition is part of the treatment. Diet therapy is difficult as it is necessary to control the intake of: energy, protein and minerals – Na, K, Ca and P in the daily food rations (DFR). Objective: The aim of the study was to assess the nutritional status and diets of haemodialysis (HD) patients. Material and method: The study involved 141 haemodialysis patients, at the average age of 65...
2018: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/29732883/lithium-ion-recognition-with-nanofluidic-diodes-through-host-guest-complexation-in-confined-geometries
#10
Mubarak Ali, Ishtiaq Ahmed, Patricio Ramirez, Saima Nasir, Salvador Mafe, Christof M Niemeyer, Wolfgang Ensinger
The lithium ion recognition is receiving significant attention because of its application in pharmaceuticals, lubricants, and, especially, in energy technology. We present a nanofluidic device for specific lithium ion recognition via host-guest complexation in a confined environment. A lithium-selective receptor molecule, the aminoethyl-benzo-12-crown-4 (BC12C4-NH2) is designed and functionalized on single conical nanopores in polyethylene terephthalate (PET) membranes. The native carboxylic acid groups on the pore walls are covalently linked with the crown ether moieties and the process is monitored from the changes in the current-voltage (I-V) curves...
May 7, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29685127/validation-of-a-self-administered-web-based-24-hour-dietary-recall-among-pregnant-women
#11
Claudia Savard, Simone Lemieux, Jacynthe Lafrenière, Catherine Laramée, Julie Robitaille, Anne-Sophie Morisset
BACKGROUND: The use of valid dietary assessment methods is crucial to analyse adherence to dietary recommendations among pregnant women. This study aims to assess the relative validity of a self-administered Web-based 24-h dietary recall, the R24W, against a pen-paper 3-day food record (FR) among pregnant women. METHODS: Sixty (60) pregnant women recruited at 9.3 ± 0.7 weeks of pregnancy in Quebec City completed, at each trimester, 3 R24W and a 3-day FR. Mean energy and nutrient intakes reported by both tools were compared using paired Student T-Tests...
April 23, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29644218/nutrition-in-the-bin-a-nutritional-and-environmental-assessment-of-food-wasted-in-the-uk
#12
Karen A Cooper, Tom E Quested, Helene Lanctuit, Diane Zimmermann, Namy Espinoza-Orias, Anne Roulin
The UK currently has the most detailed, directly measured data for food wasted in the home. This includes information on the exact types of food wasted. These data allow calculation of the nutrients within that waste, as well as its environmental impact. The results progress the conversation beyond how much food is wasted or its energy content; it permits the implications for nutrition and sustainability to be assessed in detail. Data for UK household food waste were expressed as an average waste per capita for each type of food...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29643928/effect-of-low-energy-diet-for-eight-weeks-to-adults-with-overweight-or-obesity-on-folate-retinol-vitamin-b-12-d-and-e-status-and-the-degree-of-inflammation-a-post-hoc-analysis-of-a-randomized-intervention-trial
#13
Nina Rica Wium Geiker, Mette Veller, Louise Kjoelbaek, Jette Jakobsen, Christian Ritz, Anne Raben, Arne Astrup, Janne Kunchel Lorenzen, Lesli H Larsen, Susanne Bügel
Background: Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12 , D and E status and the degree of inflammation. Methods: Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2 , completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12 , D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29642527/fluid-intake-and-beverage-consumption-description-and-their-association-with-dietary-vitamins-and-antioxidant-compounds-in-italian-adults-from-the-mediterranean-healthy-eating-aging-and-lifestyles-meal-study
#14
Armando Platania, Dora Castiglione, Dario Sinatra, Maurizio D' Urso, Marina Marranzano
The aim of the present study was to investigate the total water intake (TWI) from drinks and foods and to evaluate the correlation between the different types of drinks on energy and antioxidant intake. The cohort comprised 1602 individuals from the city of Catania in Southern Italy. A food frequency questionnaire was administered to assess dietary and water intake. The mean total water intake was 2.7 L; more than about two thirds of the sample met the European recommendations for water intake. Water and espresso coffee were the most consumed drinks...
April 9, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29642444/nutritionally-optimized-culturally-acceptable-cost-minimized-diets-for-low-income-ghanaian-families-using-linear-programming
#15
Esa-Pekka A Nykänen, Hanna E Dunning, Richmond N O Aryeetey, Aileen Robertson, Alexandr Parlesak
The Ghanaian population suffers from a double burden of malnutrition. Cost of food is considered a barrier to achieving a health-promoting diet. Food prices were collected in major cities and in rural areas in southern Ghana. Linear programming (LP) was used to calculate nutritionally optimized diets (food baskets (FBs)) for a low-income Ghanaian family of four that fulfilled energy and nutrient recommendations in both rural and urban settings. Calculations included implementing cultural acceptability for families living in extreme and moderate poverty (food budget under USD 1...
April 7, 2018: Nutrients
https://www.readbyqxmd.com/read/29548432/suitability-of-microwave-drying-for-mealworms-tenebrio-molitor-as-alternative-to-freeze-drying-impact-on-nutritional-quality-and-colour
#16
S Lenaerts, M Van Der Borght, A Callens, L Van Campenhout
Freeze drying represents the current practice to stabilize mealworms, even though it is an energy demanding technique. Therefore, it was examined in the present study whether microwave drying could be a proper alternative. To this end, the impact of both drying techniques on the proximate composition, vitamin B12 content, fatty acid profile, oxidation status and colour parameters of mealworms was investigated. Furthermore, the influence of the application of vacuum during microwave drying was studied. The different drying technologies resulted in small differences in the proximate composition, while the vitamin B12 content was only reduced by microwave drying...
July 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29528562/two-enzymes-of-the-acetone-degradation-pathway-of-desulfococcus-biacutus-coenzyme-b-12-dependent-2-hydroxyisobutyryl-coa-mutase-and-3-hydroxybutyryl-coa-dehydrogenase
#17
Jasmin Frey, Fabian Schneider, Thomas Huhn, Dieter Spiteller, Bernhard Schink, David Schleheck
Degradation of acetone by the sulfate-reducing bacterium Desulfococcus biacutus involves an acetone-activation reaction different from that used by aerobic or nitrate-reducing bacteria, because the small energy budget of sulfate-reducing bacteria does not allow for major expenditures into ATP-consuming carboxylation reactions. In the present study, an inducible coenzyme B12 -dependent conversion of 2-hydroxyisobutyryl-CoA to 3-hydroxybutyryl-CoA was demonstrated in cell-free extracts of acetone-grown D. biacutus cells, together with a NAD+ -dependent oxidation of 3-hydroxybutyryl-CoA to acetoacetyl-CoA...
March 12, 2018: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/29510788/nutritional-considerations-for-the-vegetarian-and-vegan-dancer
#18
Derrick D Brown
Vegetarianism provides a catchall term for a variety of diets that exclude the consumption of some or all animal products. Contrary to popular claims, appropriately designed and managed vegetarian diets contain foods nutritionally sufficient for health, well-being, and physical performance. Vegetarian dancers can meet their protein needs from primarily or exclusively (vegan) plant-based sources when a variety of these foods are consumed daily and energy intake is adequate. However, the quality and timing of dietary intake is of key importance to meet the physical demands typical of high intensity, intermittent types of dance styles...
March 15, 2018: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/29473272/li-2-b-12-and-li-3-b-12-prediction-of-the-smallest-tubular-and-cage-like-boron-structures
#19
Xue Dong, Said Jalife, Alejandro Vásquez-Espinal, Estefanía Ravell, Sudip Pan, José Luis Cabellos, Wei-Yan Liang, Zhong-Hua Cui, Gabriel Merino
An intriguing structural transition from the quasi-planar form of B12 cluster upon the interaction with lithium atoms is reported. High-level computations show that the lowest energy structures of LiB12 , Li2 B12 , and Li3 B12 have quasi-planar (Cs ), tubular (D6d ), and cage-like (Cs ) geometries, respectively. The energetic cost of distorting the B12 quasi-planar fragment is overcompensated by an enhanced electrostatic interaction between the Li cations and the tubular or cage-like B12 fragments, which is the main reason of such drastic structural changes, resulting in the smallest tubular (Li2 B12 ) and cage-like (Li3 B12 ) boron structures reported to date...
April 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29466283/the-relationship-between-maternal-nutrition-during-pregnancy-and-offspring-kidney-structure-and-function-in-humans-a-systematic-review
#20
REVIEW
Yu Qi Lee, Clare E Collins, Adrienne Gordon, Kym M Rae, Kirsty G Pringle
The intrauterine environment is critical for fetal growth and organ development. Evidence from animal models indicates that the developing kidney is vulnerable to suboptimal maternal nutrition and changes in health status. However, evidence from human studies are yet to be synthesised. Therefore, the aim of the current study was to systematically review current research on the relationship between maternal nutrition during pregnancy and offspring kidney structure and function in humans. A search of five databases identified 9501 articles, of which three experimental and seven observational studies met the inclusion criteria...
February 21, 2018: Nutrients
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