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https://www.readbyqxmd.com/read/27870912/atp-hydrolysis-induced-conformational-changes-in-the-vitamin-b12-transporter-btucd-revealed-by-md-simulations
#1
Chao Pan, Jingwei Weng, Wenning Wang
ATP binding cassette (ABC) transporters utilize the energy of ATP hydrolysis to uni-directionally transport substrates across cell membrane. ATP hydrolysis occurs at the nucleotide-binding domain (NBD) dimer interface of ABC transporters, whereas substrate translocation takes place at the translocation pathway between the transmembrane domains (TMDs), which is more than 30 angstroms away from the NBD dimer interface. This raises the question of how the hydrolysis energy released at NBDs is "transmitted" to trigger the conformational changes at TMDs...
2016: PloS One
https://www.readbyqxmd.com/read/27825941/consumption-of-ultra-processed-foods-predicts-diet-quality-in-canada
#2
Jean-Claude Moubarac, M Batal, M L Louzada, E Martinez Steele, C A Monteiro
This study describes food consumption patterns in Canada according to the types of food processing using the Nova classification and investigates the association between consumption of ultra-processed foods and the nutrient profile of the diet. Dietary intakes of 33,694 individuals from the 2004 Canadian Community Health Survey aged 2 years and above were analyzed. Food and drinks were classified using Nova into unprocessed or minimally processed foods, processed culinary ingredients, processed foods and ultra-processed foods...
November 4, 2016: Appetite
https://www.readbyqxmd.com/read/27806272/allosteric-signaling-is-bidirectional-in-an-outer-membrane-transport-protein
#3
Arthur Sikora, Benesh Joseph, Morgan Matson, Jacob R Staley, David S Cafiso
In BtuB, the Escherichia coli TonB-dependent transporter for vitamin B12, substrate binding to the extracellular surface unfolds a conserved energy coupling motif termed the Ton box into the periplasm. This transmembrane signaling event facilitates an interaction between BtuB and the inner-membrane protein TonB. In this study, continuous-wave and pulse electron paramagnetic resonance in a native outer-membrane preparation demonstrate that signaling also occurs from the periplasmic to the extracellular surface in BtuB...
November 1, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27797190/toward-the-design-of-photoresponsive-conditional-antivitamins-b12-a-transient-absorption-study-of-an-arylcobalamin-and-an-alkynylcobalamin
#4
Nicholas A Miller, Theodore E Wiley, Kenneth G Spears, Markus Ruetz, Christoph Kieninger, Bernhard Kräutler, Roseanne J Sension
Cobalamins are of widespread importance in biology. Both of the cofactors essential for human metabolism, the organocobalamins coenzyme B12 and methylcobalamin, are highly photolabile, as are other alkylcobalamins. The alkynylcobalamin phenylethynylcobalamin (PhEtyCbl) and the arylcobalamin 4-ethylphenylcobalamin (EtPhCbl) with "atypical" Co-C-bonds to unsaturated carbons, were recently designed as metabolically inert cobalamins, classified as "antivitamins B12". The further development of an ideal light-activated or "conditional" antivitamin B12 would require it to be readily converted by light into an active B12 vitamin form...
October 24, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27792245/malnutrition-and-risk-of-structural-brain-changes-seen-on-magnetic-resonance-imaging-in-older-adults
#5
Marian A E de van der Schueren, Sabine Lonterman-Monasch, Wiesje M van der Flier, Mark H Kramer, Andrea B Maier, Majon Muller
OBJECTIVES: To study the associations between protein energy malnutrition, micronutrient malnutrition, brain atrophy, and cerebrovascular lesions. DESIGN: Cross-sectional. SETTING: Geriatric outpatient clinic. PARTICIPANTS: Older adults (N = 475; mean age 80 ± 7). MEASUREMENTS: Nutritional status was assessed using the Mini Nutritional Assessment (MNA) and according to serum micronutrient levels (vitamins B1, B6, B12, D; folic acid)...
October 28, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27754376/associations-of-milk-consumption-and-vitamin-b%C3%A2-and-%C3%AE-12-derived-from-milk-with-fitness-anthropometric-and-biochemical-indices-in-children-the-healthy-growth-study
#6
George Moschonis, Ellen G H M van den Heuvel, Christina Mavrogianni, Cécile M Singh-Povel, Michalis Leotsinidis, Yannis Manios
The benefits of dairy consumption seem to extend beyond its significant contribution to ensuring nutrient intake adequacy as indicated by the favourable associations with several health outcomes reported by different studies. The aims of the present study were to examine the associations of milk consumption with fitness, anthropometric and biochemical indices in children and further explore whether the observed associations are attributed to vitamins B₂ and B12 derived from milk. A representative subsample of 600 children aged 9-13 years participating in the Healthy Growth Study was examined...
October 13, 2016: Nutrients
https://www.readbyqxmd.com/read/27744386/comparison-of-dietary-intakes-between-a-large-online-cohort-study-etude-nutrinet-sant%C3%A3-and-a-nationally-representative-cross-sectional-study-etude-nationale-nutrition-sant%C3%A3-in-france-addressing-the-issue-of-generalizability-in-e-epidemiology
#7
Valentina A Andreeva, Valérie Deschamps, Benoît Salanave, Katia Castetbon, Charlotte Verdot, Emmanuelle Kesse-Guyot, Serge Hercberg
Despite some advantages over traditional methods, Web-based studies elicit concerns about generalizability. To address this issue, we compared dietary intakes between an electronic (e-) cohort study and a nationally representative survey. We studied 49,443 French volunteers aged 18-74 years recruited during 2009-2010 in the NutriNet-Santé Study, a general population-based e-cohort study. The Etude Nationale Nutrition Santé (ENNS; 2006-2007), a cross-sectional study with a nationally representative sample of 2,754 French adults aged 18-74 years, served as the reference data set...
November 1, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27603881/-pregnancy-and-breastfeeding
#8
María Eugenia Flores-Quijano, Solange Heller-Rouassant
During pregnancy and breastfeeding the demand for nutrients that promote the growth and development of the fetus, maternal tissues and breastmilk production is increased. Milk and dairy products provide energy, proteins, fatty acids, carbohydrates, calcium, phosphorus, vitamins D and B12, therefore their importance during pregnancy and breastfeeding. The energy through food supply allows the development and growth from the conception; protein promotes the rapid growth of the maternal and fetal tissues: fatty acids stimulate the development of the fetus central nervous system; carbohydrates are essential to support fetal brain growth; calcium is essential for the formation and mineralization of the fetus skeleton, while vitamin D promotes calcium absorption and the development of the nervous and immune systems...
September 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27548572/hydration-dynamics-of-a-peripheral-membrane-protein
#9
Olivier Fisette, Christopher Päslack, Ryan Barnes, J Mario Isas, Ralf Langen, Matthias Heyden, Songi Han, Lars V Schäfer
Water dynamics in the hydration shell of the peripheral membrane protein annexin B12 were studied using MD simulations and Overhauser DNP-enhanced NMR. We show that retardation of water motions near phospholipid bilayers is extended by the presence of a membrane-bound protein, up to around 10 Å above that protein. Near the membrane surface, electrostatic interactions with the lipid head groups strongly slow down water dynamics, whereas protein-induced water retardation is weaker and dominates only at distances beyond 10 Å from the membrane surface...
September 14, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27547390/validation-of-a-food-frequency-questionnaire-for-assessing-vitamin-intake-of-japanese-women-in-early-and-late-pregnancy-with-and-without-nausea-and-vomiting
#10
Seung Chik Jwa, Kohei Ogawa, Minatsu Kobayashi, Naho Morisaki, Haruhiko Sago, Takeo Fujiwara
Maternal vitamin intake during pregnancy is crucial for pregnancy outcomes and the child's subsequent health. However, there are few valid instruments for assessing vitamin intake that address the effects of nausea and vomiting during pregnancy (NVP). This study aimed to investigate the validity of a FFQ concerning vitamin intake during early and late pregnancy with and without NVP. The participants comprised 200 Japanese pregnant women who completed the FFQ and from whom blood samples were taken in early and late pregnancy...
2016: Journal of Nutritional Science
https://www.readbyqxmd.com/read/27546325/analysis-of-the-dietary-factors-contributing-to-the-future-osteoporosis-risk-in-young-polish-women
#11
Patrycja Sidor, Dominika Głąbska, Dariusz Włodarek
BACKGROUND: The osteoporosis is becoming serious problem for the preventive healthcare, that is stated for Poland and western countries. The loss of bone mass in women may be even five times higher than in men, so in the osteoporosis preventive strategies, young women are indicated as best potential target group. OBJECTIVE: The aim of the study was to analyze the osteoporosis risk, on the basis of diet assessment in young Polish women, while satisfying nutritional needs for bone health-related nutrients was taken into account...
2016: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/27499303/malnutrition-in-very-old-hospitalized-patients-a-new-etiologic-factor-of-anemia
#12
E Frangos, A Trombetti, C E Graf, V Lachat, N Samaras, U M Vischer, D Zekry, R Rizzoli, F R Herrmann
BACKGROUND: Anemia and malnutrition are highly prevalent, frequently concomitant and associated with negative outcomes and mortality in the elderly. OBJECTIVES: To evaluate the association between these two entities, and test the hypothesis that protein-energy deficit could be etiology of anemia. DESIGN: Prospective case-control study. SETTING: Geriatric and Rehabilitation Hospital, Geneva University Hospitals, Switzerland...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27455502/validation-of-total-skin-electron-irradiation-tsei-technique-dosimetry-data-by-monte-carlo-simulation
#13
Alexander Nevelsky, Egor Borzov, Shahar Daniel, Rachel Bar-Deroma
Total skin electron irradiation (TSEI) is a complex technique which requires many nonstandard measurements and dosimetric procedures. The purpose of this work was to validate measured dosimetry data by Monte Carlo (MC) simulations using EGSnrc-based codes (BEAMnrc and DOSXYZnrc). Our MC simulations consisted of two major steps. In the first step, the incident electron beam parameters (energy spectrum, FWHM, mean angular spread) were adjusted to match the measured data (PDD and profile) at SSD = 100 cm for an open field...
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27440097/nutritional-status-of-children-from-cochabamba-bolivia-a-cross-sectional-study
#14
Cristina Masuet-Aumatell, Josep Maria Ramon-Torrell, Marta Banqué-Navarro, María Del Rosario Dávalos-Gamboa, Sandra Lucía Montaño-Rodríguez
OBJECTIVE: To assess the adequacy of energy and nutritional intakes compared to recommended daily intakes (RDIs) in schoolchildren from the Cochabamba region (Bolivia) and to determine micronutrient intake distributions across different ages and genders. METHODS: This nutritional study (n = 315) was part of a larger population-based crosssectional study (the "Bolkid" survey) that collected data on schoolchildren 5-16 years old in 2010 in the Cochabamba region. Information about food intake was gathered with a semiquan-titative, food-frequency, parent-administered questionnaire about l2 months before the study...
December 2015: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/27403373/nutritional-status-and-anthropometric-indices-in-high-school-girls-in-ilam-west-iran
#15
Fatemeh Jamalikandazi, Elham Ranjbar, Eskandar Gholami-Parizad, Zeinab Ghazanfari, Seyed-Ali Mostafavi
Background. Adolescence is one of the most challenging periods for human growth and nutritional status. The aim of this study was to assess the nutritional status and anthropometric indices in high school girls in Ilam. Methods. This cross-sectional study was performed on 360 domestic high school girl students chosen randomly by cluster sampling. Data were gathered through interviews performed by a dietitian to fill 24-hour dietary recall and food frequency and demographic questionnaires. Then we performed the anthropometric measurements and we compared the results with CDC2000 standards...
2016: Scientifica
https://www.readbyqxmd.com/read/27395465/-prevention-of-alzheimer-s-disease-and-nutrients
#16
Mieko Otsuka
The dietary recommendations for the prevention and management of Alzheimer's disease (AD), are the Mediterranean diet and the Japanese-style diet, both of which contain well-balanced nutrients from fish and vegetables. These diets are rich in vitamin E, carotenes, antioxidant flavonoids, vitamin B12, folate, and n-3PUFA. According to recent review supplementation of folate and vitamin E may protect against elderly people's cognitive decline when the serum folate is <12 nmol/L or the vitamin E intake is <6...
July 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27350397/cerebral-hypoperfusion-and-glucose-hypometabolism-key-pathophysiological-modulators-promote-neurodegeneration-cognitive-impairment-and-alzheimer-s-disease
#17
Mak Adam Daulatzai
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse pathological mechanisms including cerebral hypoperfusion and glucose hypometabolism. These risk factors trigger neuroinflammation and oxidative-nitrosative stress that in turn decrease nitric oxide and enhance endothelin, Amyloid-β deposition, cerebral amyloid angiopathy, and blood-brain barrier disruption. Proinflammatory cytokines, endothelin-1, and oxidative-nitrosative stress trigger several pathological feedforward and feedback loops...
June 27, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27334774/complementary-feeding-diets-made-of-local-foods-can-be-optimized-but-additional-interventions-will-be-needed-to-meet-iron-and-zinc-requirements-in-6-to-23-month-old-children-in-low-and-middle-income-countries
#18
Saskia J M Osendarp, Britt Broersen, Marti J van Liere, Luz M De-Regil, Lavannya Bahirathan, Eva Klassen, Lynnette M Neufeld
BACKGROUND: The question whether diets composed of local foods can meet recommended nutrient intakes in children aged 6 to 23 months living in low- and middle-income countries is contested. OBJECTIVE: To review evidence of studies evaluating whether (1) macro- and micronutrient requirements of children aged 6 to 23 months from low- and middle-income countries are met by the consumption of locally available foods ("observed intake") and (2) nutrient requirements can be met when the use of local foods is optimized, using modeling techniques ("modeled intake")...
December 2016: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/27324530/mtra-of-the-sodium-ion-pumping-methyltransferase-binds-cobalamin-in-a-unique-mode
#19
Tristan Wagner, Ulrich Ermler, Seigo Shima
In the three domains of life, vitamin B12 (cobalamin) is primarily used in methyltransferase and isomerase reactions. The methyltransferase complex MtrA-H of methanogenic archaea has a key function in energy conservation by catalysing the methyl transfer from methyl-tetrahydromethanopterin to coenzyme M and its coupling with sodium-ion translocation. The cobalamin-binding subunit MtrA is not homologous to any known B12-binding proteins and is proposed as the motor of the sodium-ion pump. Here, we present crystal structures of the soluble domain of the membrane-associated MtrA from Methanocaldococcus jannaschii and the cytoplasmic MtrA homologue/cobalamin complex from Methanothermus fervidus...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27311793/typology-of-eaters-based-on-conventional-and-organic-food-consumption-results-from-the-nutrinet-sant%C3%A3-cohort-study
#20
Julia Baudry, Mathilde Touvier, Benjamin Allès, Sandrine Péneau, Caroline Méjean, Pilar Galan, Serge Hercberg, Denis Lairon, Emmanuelle Kesse-Guyot
Limited information is available on large-scale populations regarding the socio-demographic and nutrient profiles and eating behaviour of consumers, taking into account both organic and conventional foods. The aims of this study were to draw up a typology of consumers according to their eating habits, based both on their dietary patterns and the mode of food production, and to outline their socio-demographic, behavioural and nutritional characteristics. Data were collected from 28 245 participants of the NutriNet-Santé study...
August 2016: British Journal of Nutrition
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