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hyperbaric oxygen AND concussion

Amir Hadanny, Shai Efrati
Persistent post-concussion syndrome caused by mild traumatic brain injury has become a major cause of morbidity and poor quality of life. Unlike the acute care of concussion, there is no consensus for treatment of chronic symptoms. Moreover, most of the pharmacologic and non-pharmacologic treatments have failed to demonstrate significant efficacy on both the clinical symptoms as well as the pathophysiologic cascade responsible for the permanent brain injury. This article reviews the pathophysiology of PCS, the diagnostic tools and criteria, the current available treatments including pharmacotherapy and different cognitive rehabilitation programs, and promising new treatment directions...
August 2016: Expert Review of Neurotherapeutics
Susan Churchill, R Scott Miller, Kayla Deru, Steffanie H Wilson, Lindell K Weaver
Simple reaction time (SRT) and procedural reaction time (PRT) are speed-of-processing tasks in the Automated Neuropsychological Assessment Metrics (ANAM) that may be sensitive to mild traumatic brain injury (mTBI). The investigators measured SRT and PRT throughput (correct responses per minute) at baseline, 6 weeks, and 13 weeks in military personnel with mTBI randomized to local care or 40 chamber sessions (sham-1.2 atmospheres absolute [ATA] air, hyperbaric oxygen-1.5 ATA O2). Scores were assessed at baseline using univariate analysis of variance and across time with repeated measures methods...
May 2016: Military Medicine
Michael J Ellis, Lesley Ritchie, Erin Selci, Stephanie Chu, Patrick McDonald, Kelly Russell
BACKGROUND: Concussion is an emerging public health concern, but care of patients with a concussion is presently unregulated in Canada. METHODS: Independent, blinded Google Internet searches were conducted for the terms "concussion" and "concussion clinic" and each of the Canadian provinces and territories. The first 10 to 15 concussion healthcare providers per province were identified. A critical appraisal of healthcare personnel and services offered on the provider's Web site was conducted...
February 10, 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Fei Wang, Yong Wang, Tao Sun, Hua-Lin Yu
Compelling evidence suggests the advantage of hyperbaric oxygen therapy (HBOT) in traumatic brain injury. The present meta-analysis evaluated the outcomes of HBOT in patients with traumatic brain injury (TBI). Prospective studies comparing hyperbaric oxygen therapy vs. control in patients with mild (GCS 13-15) to severe (GCS 3-8) TBI were hand-searched from medical databases using the terms "hyperbaric oxygen therapy, traumatic brain injury, and post-concussion syndrome". Glasgow coma scale (GCS) was the primary outcome, while Glasgow outcome score (GOS), overall mortality, and changes in post-traumatic stress disorder (PTSD) score, constituted the secondary outcomes...
May 2016: Neurological Sciences
Vivian A Guedes, Shuojing Song, Martina Provenzano, Cesario V Borlongan
Traumatic brain injury (TBI) is an intracranial injury caused by external trauma leading to different degrees of brain damage. TBI can cause a wide array of symptoms and range in severity from concussion to coma and death. The link between TBI and posttraumatic stress disorder (PTSD) has received increasing attention due to the high incidence of these conditions in soldiers returning from recent conflicts. TBI has been associated with an increased risk of PTSD. Additionally, TBI and PTSD often demonstrate overlapping symptoms...
2016: Expert Review of Neurotherapeutics
Sigal Tal, Amir Hadanny, Nadav Berkovitz, Efrat Sasson, Eshel Ben-Jacob, Shai Efrati
PURPOSE: Recent clinical studies present convincing evidence that hyperbaric oxygen therapy (HBOT) may be the coveted neurotherapeutic method for brain repair. One of the most interesting ways in which HBOT can induce neuroplasticity is angiogenesis. The objective in this study was to assess the neurotherapeutic effect of HBOT in post TBI patients using brain perfusion imaging and clinical cognitive functions. METHODS: Retrospective analysis of patients suffering from chronic neuro-cognitive impairment from TBI treated with HBOT...
2015: Restorative Neurology and Neuroscience
Xavier A Figueroa, James K Wright
The current debate surrounding the use of hyperbaric oxygen (HBO2) for neurological indications, specifically mild to moderate chronic traumatic brain injury (mTBI) and post-concussion syndrome (PCS), is mired in confusion due to the use of non-validated controls and an unfamiliarity by many practitioners of HBO2 therapy with the experimental literature. In the past 40 years, the use of an air sham (21% oxygen, 1.14-1.5 atmospheres absolute/atm abs) in clinical and animal studies, instead of observational or crossover controls, has led to false acceptance of the null hypothesis (declaring no effect when one is present), due to the biological activity of these "sham" controls...
July 2015: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
E George Wolf, Laura M Baugh, Christine M Schubert Kabban, Michael F Richards, Jennifer Prye
OBJECTIVE: Determine changes in cognition and post-traumatic stress disorder (PTSD) symptoms in subjects with traumatic brain injury (TBI) exposed to 2.4 atmospheres absolute (atm abs) breathing 100% oxygen vs. sham (1.3 atm-abs air). METHODS: Fifty randomized subjects completed a total of 30 exposures. A concussion history was taken, then baseline, post-series, and six-week follow-up immediate post-concussion assessment and cognitive testing, Brain-checkers and PTSD Checklist for Military (PCL-M) tests were administered...
July 2015: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Qin Hu, Anatol Manaenko, Zhenni Guo, Lei Huang, Jiping Tang, John H Zhang
Post concussion syndrome (PCS) is a set of symptoms succeeding in 25 % of mild traumatic brain injury (mTBI) patients. Hyperbaric oxygen therapy (HBOT) has been demonstrated as an effective method for treating acute and severe TBI, but its efficacy in PCS remains controversial. In this editorial, we reviewed the clinical studies of HBOT in PCS, summarized the limitations of these studies, and discussed the limitations: inappropriate Sham group using room air at 1.2 or 1.3 ATA; delayed HBO administration; subjective assessment methods; time point for outcome assessment and small sample size...
2015: Medical Gas Research
Paul G Harch
Hyperbaric oxygen therapy is a treatment for wounds in any location and of any duration that has been misunderstood for 353 years. Since 2008 it has been applied to the persistent post-concussion syndrome of mild traumatic brain injury by civilian and later military researchers with apparent conflicting results. The civilian studies are positive and the military-funded studies are a mixture of misinterpreted positive data, indeterminate data, and negative data. This has confused the medical, academic, and lay communities...
2015: Medical Gas Research
David X Cifu, Kathy W Hoke, Paul A Wetzel, Joanna R Wares, George Gitchel, William Carne
The effects of hyperbaric oxygen (HBO2) on eye movement abnormalities in 60 military servicemembers with at least one mild traumatic brain injury (TBI) from combat were examined in a single-center, randomized, double-blind, sham-controlled, prospective study at the Naval Medicine Operational Training Center. During the 10 wk of the study, each subject was delivered a series of 40, once a day, hyperbaric chamber compressions at a pressure of 2.0 atmospheres absolute (ATA). At each session, subjects breathed one of three preassigned oxygen fractions (10...
2014: Journal of Rehabilitation Research and Development
R Scott Miller, Lindell K Weaver, Nazanin Bahraini, Susan Churchill, Robert C Price, Virginia Skiba, James Caviness, Scott Mooney, Brian Hetzell, Jun Liu, Kayla Deru, Richard Ricciardi, Susan Fracisco, Nicole C Close, Gerald W Surrett, Corinna Bartos, Margaret Ryan, Lisa A Brenner
IMPORTANCE: Improvement has been anecdotally observed in patients with persistent postconcussion symptoms (PCS) after mild traumatic brain injury following treatment with hyperbaric oxygen (HBO). The effectiveness of HBO as an adjunctive treatment for PCS is unknown to date. OBJECTIVES: To compare the safety of and to estimate the efficacy for symptomatic outcomes from standard PCS care alone, care supplemented with HBO, or a sham procedure. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, double-blind, sham-controlled clinical trial of 72 military service members with ongoing symptoms at least 4 months after mild traumatic brain injury enrolled at military hospitals in Colorado, North Carolina, California, and Georgia between April 26, 2011, and August 24, 2012...
January 2015: JAMA Internal Medicine
Charles W Hoge, Wayne B Jonas
No abstract text is available yet for this article.
January 2015: JAMA Internal Medicine
Matthew C Davis, Mohammadali M Shoja, Shane R Tubbs, Christoph J Griessenauer
In this editorial, the value of hyperbaric oxygen therapy in the management of chronic post-concussive syndrome following mild traumatic brain injury is discussed.
2014: Medical Gas Research
P Gunnar Brolinson
OBJECTIVE: To systematically review the evidence for rest, treatment, and rehabilitation after sport-related concussion. DATA SOURCES: Nine databases including PubMed, Cochrane Central Register of Controlled Trials, Sport Discus, and Web of Science were searched for studies that evaluated the effect of rest separately from the effects of treatment and/or rehabilitation, using words related to concussion, mild traumatic brain injury, rest, treatment outcome, and therapy...
January 2014: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Rahav Boussi-Gross, Haim Golan, Gregori Fishlev, Yair Bechor, Olga Volkov, Jacob Bergan, Mony Friedman, Dan Hoofien, Nathan Shlamkovitch, Eshel Ben-Jacob, Shai Efrati
BACKGROUND: Traumatic brain injury (TBI) is the leading cause of death and disability in the US. Approximately 70-90% of the TBI cases are classified as mild, and up to 25% of them will not recover and suffer chronic neurocognitive impairments. The main pathology in these cases involves diffuse brain injuries, which are hard to detect by anatomical imaging yet noticeable in metabolic imaging. The current study tested the effectiveness of Hyperbaric Oxygen Therapy (HBOT) in improving brain function and quality of life in mTBI patients suffering chronic neurocognitive impairments...
2013: PloS One
David X Cifu, William C Walker, Steven L West, Brett B Hart, Laura Manning Franke, Adam Sima, Carolyn W Graham, William Carne
OBJECTIVE: Mild traumatic brain injury (mTBI) and postconcussion syndrome (PCS) are common among military combatants. Hyperbaric oxygen (HBO2 ) is a proposed treatment for these conditions, but it has not been rigorously studied. The objective of this study was to determine the effects of HBO2 by 3 months post compression at 2 commonly employed dosing levels to treat PCS; whether specific subgroups may have benefited; and if no overall effect was found, whether benefit is masked by other conditions...
February 2014: Annals of Neurology
Brian F McCrary, Lindell Weaver, Kevin Marrs, R Scott Miller, Cheryl Dicks, Kayla Deru, Nicole Close, Marla DeJong
No abstract text is available yet for this article.
September 2013: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Mike Bennett
No abstract text is available yet for this article.
September 2013: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
David X Cifu, Brett B Hart, Steven L West, William Walker, William Carne
BACKGROUND: The high incidence of persistent postconcussion symptoms in service members with combat-related mild traumatic brain injury has prompted research in the use of hyperbaric oxygen (HBO2) for management. OBJECTIVE: The effects of HBO2 on persistent postconcussion symptoms in 60 military service members with at least 1 combat-related mild traumatic brain injury were examined in a single-center, double-blind, randomized, sham-controlled, prospective trial at the Naval Medicine Operational Training Center at Naval Air Station Pensacola...
January 2014: Journal of Head Trauma Rehabilitation
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