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JOURNAL ARTICLE
Ling Li, Shichao Pang, Fabian Starnecker, Bertram Mueller-Myhsok, Heribert Schunkert
BACKGROUND AND AIMS: It is not clear how a polygenic risk score (PRS) can be best combined with guideline-recommended tools for cardiovascular disease (CVD) risk prediction, e.g. SCORE2. METHODS: A PRS for coronary artery disease (CAD) was calculated in participants of UK Biobank (n = 432 981). Within each tenth of the PRS distribution, the odds ratios (ORs)-referred to as PRS-factor-for CVD (i.e. CAD or stroke) were compared between the entire population and subgroups representing the spectrum of clinical risk...
March 29, 2024: European Heart Journal
#2
JOURNAL ARTICLE
Gjin Ndrepepa, Sebastian Kufner, Salvatore Cassese, Michael Joner, Erion Xhepa, Jens Wiebe, Hendrik B Sager, Thorsten Kessler, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati
The association between uric acid (UA) and long-term mortality in patients with coronary artery disease is poorly investigated. We assessed the association between UA and 10-year mortality after percutaneous coronary intervention (PCI) in 3,998 patients who underwent PCI. Patients were categorized in groups according to UA tertiles: tertile 1 (UA <5.80 mg/100 ml, n = 1,347), tertile 2 (UA 5.80 to 7.04 mg/100 ml, n = 1,340), and tertile 3 (UA >7.94 mg/100 ml, n = 1,311). The primary outcome was 10-year all-cause mortality...
April 1, 2024: American Journal of Cardiology
#3
JOURNAL ARTICLE
Theodora Tacke, Pascal Nohl-Deryk, Neelam Lingwal, Lara Marie Reimer, Fabian Starnecker, Corina Güthlin, Ferdinand M Gerlach, Heribert Schunkert, Stephan Jonas, Angelina Müller
OBJECTIVE: In Germany, only a few standardized evaluation tools for assessing the usability of mobile Health apps exist so far. This study aimed to translate and validate the English patient version for standalone apps of the mHealth App Usability Questionnaire (MAUQ) into a German version. METHODS: Following scientific guidelines for translation and cross-cultural adaptation, the patient version for standalone apps was forward and back-translated from English into German by an expert panel...
2024: Digital Health
#4
JOURNAL ARTICLE
Gjin Ndrepepa, Salvatore Cassese, Erion Xhepa, Michael Joner, Hendrik B Sager, Sebastian Kufner, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati
BACKGROUND: The association of aspirin loading with the risk of coronary no-reflow (CNR) after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has not been investigated. We assessed the association of aspirin loading before PCI with CNR in patients with AMI. MATERIALS AND METHODS: This study included 3100 patients with AMI undergoing PCI. Of them, 2812 patients received aspirin loading (a single oral [or chewed] or intravenous dose of 150-300 mg) and 288 patients did not receive aspirin loading before PCI...
January 24, 2024: European Journal of Clinical Investigation
#5
JOURNAL ARTICLE
Finn Syryca, Costanza Pellegrini, Tobias Rheude, Florian Zobel, Katharina Kornhuber, Erion Xhepa, N Patrick Mayr, Hector A Alvarez-Covarrubias, Stefan Holdenrieder, Heribert Schunkert, Christian Thilo, Adnan Kastrati, Michael Joner
BACKGROUND: Data on systemic inflammatory response syndrome (SIRS) after transcatheter aortic valve implantation (TAVI) are scarce and limited to small cohorts. We aimed to investigate its incidence and mid-term impact in a large cohort of TAVI patients. METHODS: From January 2018 to December 2020, 717 patients with severe aortic valve stenosis undergoing TAVI were included. SIRS was defined as fulfilling at least two of the following criteria within 48 h from the procedure: leucocyte count >12...
November 30, 2023: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#6
JOURNAL ARTICLE
Fabian Starnecker, Lara Marie Reimer, Leon Nissen, Marko Jovanović, Maximilian Kapsecker, Susanne Rospleszcz, Moritz von Scheidt, Johannes Krefting, Nils Krüger, Benedikt Perl, Jens Wiehler, Ruoyu Sun, Stephan Jonas, Heribert Schunkert
BACKGROUND: Identifying high-risk individuals is crucial for preventing cardiovascular diseases (CVDs). Currently, risk assessment is mostly performed by physicians. Mobile health apps could help decouple the determination of risk from medical resources by allowing unrestricted self-assessment. The respective test results need to be interpretable for laypersons. OBJECTIVE: Together with a patient organization, we aimed to design a digital risk calculator that allows people to individually assess and optimize their CVD risk...
December 8, 2023: JMIR Cardio
#7
EDITORIAL
Redouane Aherrahrou, Thomas Eschenhagen, Inke R König, Nilesh J Samani, Heribert Schunkert, Zouhair Aherrahrou
No abstract text is available yet for this article.
November 20, 2023: Nature Genetics
#8
JOURNAL ARTICLE
Gjin Ndrepepa, Salvatore Cassese, Erion Xhepa, Michael Joner, Hendrik B Sager, Sebastian Kufner, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati
BACKGROUND: The frequency and prognostic value of coronary no-reflow (CNR) was investigated in studies that have used an outdated reperfusion therapy in terms of stent technology and antithrombotic drugs. We assessed the association of CNR with adverse outcomes in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and newer antithrombotic drugs, ticagrelor or prasugrel. METHODS: This study included 3100 patients with AMI who underwent PCI with current DES and third-generation P2Y12 inhibitors...
November 14, 2023: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#9
JOURNAL ARTICLE
Michal Mokry, Arjan Boltjes, Lotte Slenders, Gemma Bel-Bordes, Kai Cui, Eli Brouwer, Joost M Mekke, Marie A C Depuydt, Nathalie Timmerman, Farahnaz Waissi, Maarten C Verwer, Adam W Turner, Mohammad Daud Khan, Chani J Hodonsky, Ernest Diez Benavente, Robin J G Hartman, Noortje A M van den Dungen, Nico Lansu, Emilia Nagyova, Koen H M Prange, Jason C Kovacic, Johan L M Björkegren, Eleftherios Pavlos, Evangelos Andreakos, Heribert Schunkert, Gary K Owens, Claudia Monaco, Aloke V Finn, Renu Virmani, Nicholas J Leeper, Menno P J de Winther, Johan Kuiper, Gert J de Borst, Erik S G Stroes, Mete Civelek, Dominique P V de Kleijn, Hester M den Ruijter, Folkert W Asselbergs, Sander W van der Laan, Clint L Miller, Gerard Pasterkamp
Histopathological studies have revealed key processes of atherosclerotic plaque thrombosis. However, the diversity and complexity of lesion types highlight the need for improved sub-phenotyping. Here we analyze the gene expression profiles of 654 advanced human carotid plaques. The unsupervised, transcriptome-driven clustering revealed five dominant plaque types. These plaque phenotypes were associated with clinical presentation and showed differences in cellular compositions. Validation in coronary segments showed that the molecular signature of these plaques was linked to coronary ischemia...
December 2022: Nat Cardiovasc Res
#10
JOURNAL ARTICLE
Anne Cornelissen, Neel V Gadhoke, Kathleen Ryan, Chani J Hodonsky, Rebecca Mitchell, Nathan Bihlmeyer, ThuyVy Duong, Zhifen Chen, Armelle Dikongue, Atsushi Sakamoto, Yu Sato, Rika Kawakami, Masayuki Mori, Kenji Kawai, Raquel Fernandez, Saikat Kumar B Ghosh, Ryan Braumann, Biniyam Abebe, Robert Kutys, Matthew Kutyna, Maria E Romero, Frank D Kolodgie, Clint L Miller, Charles C Hong, Megan L Grove, Jennifer A Brody, Nona Sotoodehnia, Dan E Arking, Heribert Schunkert, Braxton D Mitchell, Liang Guo, Renu Virmani, Aloke V Finn
BACKGROUND: Polygenic risk scores (PRSs) for coronary artery disease (CAD) potentially improve cardiovascular risk prediction. However, their relationship with histopathologic features of CAD has never been examined systematically. METHODS: From 4327 subjects referred to CVPath by the State of Maryland Office Chief Medical Examiner for sudden death between 1994 and 2015, 2455 cases were randomly selected for genotyping. We generated PRS from 291 known CAD risk loci...
November 2, 2023: Arteriosclerosis, Thrombosis, and Vascular Biology
#11
JOURNAL ARTICLE
Tobias Koch, Tobias Lenz, Tobias Rheude, Salvatore Cassese, Mej Kazazi, Erion Xhepa, Thorsten Kessler, Jens Wiebe, Miroslaw Ferenc, Karl-Ludwig Laugwitz, Michael Joner, Heribert Schunkert, Adnan Kastrati, Sebastian Kufner
OBJECTIVES: To investigate long-term incidence of recurrent revascularization events after percutaneous treatment of drug-eluting in-stent restenosis (DES-ISR). BACKGROUND: Treatment of patients with recurrence of ISR remains particularly challenging with data and guideline recommendations for repeat PCI being scant. METHODS: In this post-hoc analysis, 402 patients (500 lesions) being assigned to plain balloon (PB), drug-coated balloon (DCB) or drug-eluting stent (DES) in the randomized ISAR-DESIRE 3 trial were followed-up over a median of 10...
October 18, 2023: JACC. Cardiovascular Interventions
#12
JOURNAL ARTICLE
Costanza Pellegrini, Markus Freißmuth, Tobias Rheude, David Graas, N Patrick Mayr, Finn Syryca, Hector A Alvarez-Covarrubias, Andrei Fetcu, Judith Hübner, Carsten Lennerz, Heribert Schunkert, Adnan Kastrati, Erion Xhepa, Michael Joner
BACKGROUND: Permanent pacemaker implantation (PPI) remains a relevant complication after transcatheter aortic valve implantation (TAVI) and its impact on outcome remains controversial. AIMS: This study aimed to analyze the effects of implantation depth on PPI at 30 days and assess its impact on outcome with the balloon-expandable Sapien 3 (S3) prosthesis. METHODS: Between 2014 and 2018, 849 patients without previous pacemaker undergoing transfemoral TAVI with the S3 were included...
October 25, 2023: Catheterization and Cardiovascular Interventions
#13
JOURNAL ARTICLE
Finn Syryca, Costanza Pellegrini, Marie Gollreiter, Philipp Nicol, N Patrick Mayr, Hector A Alvarez-Covarrubias, Niklas Altaner, Tobias Rheude, Stefan Holdenrieder, Heribert Schunkert, Adnan Kastrati, Michael Joner, Erion Xhepa, Teresa Trenkwalder
OBJECTIVES: Systemic inflammatory response syndrome (SIRS) is a common finding after cardiovascular interventions. Data on the incidence of SIRS and its impact on outcome in patients undergoing transcatheter edge-to-edge mitral valve repair (MV-TEER) for mitral regurgitation (MR) is lacking. METHODS: From January 2013 to December 2020, 373 patients with moderate or severe MR undergoing MV-TEER were included. SIRS was defined as at least two of the following criteria within 48 h after the procedure: leucocyte count > 12...
October 23, 2023: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#14
JOURNAL ARTICLE
Katharina Knoll, Stefanie Rosner, Stefan Gross, Dino Dittrich, Carsten Lennerz, Teresa Trenkwalder, Stefanie Schmitz, Stefan Sauer, Christian Hentschke, Marcus Dörr, Christian Kloss, Heribert Schunkert, Wibke Reinhard
Telemedicine has been shown to improve the outcome of heart failure (HF) patients in addition to medical and device therapy. We investigate the effectiveness of a comprehensive telehealth programme in patients with recent hospitalisation for HF on subsequent HF hospitalisations and mortality compared to usual care in a real-world setting. The telehealth programme consists of daily remote telemonitoring of HF signs/symptoms and regular individualised telecoaching sessions. Between January 2018 and September 2020, 119,715 patients of a German health insurer were hospitalised for HF and were eligible for participation in the programme...
October 17, 2023: NPJ Digital Medicine
#15
JOURNAL ARTICLE
Alexander Dutsch, Carsten Uhlig, Matthias Bock, Christian Graesser, Sven Schuchardt, Steffen Uhlig, Heribert Schunkert, Michael Joner, Stefan Holdenrieder, Katharina Lechner
BACKGROUND: Severe coronavirus disease 2019 (COVID-19) disease courses are characterized by immuno-inflammatory, thrombotic, and parenchymal alterations. Prediction of individual COVID-19 disease courses to guide targeted prevention remains challenging. We hypothesized that a distinct serologic signature precedes surges of IL-6/D-dimers in severely affected COVID-19 patients. METHODS: We performed longitudinal plasma profiling, including proteome, metabolome, and routine biochemistry, on seven seropositive, well-phenotyped patients with severe COVID-19 referred to the Intensive Care Unit at the German Heart Center...
September 27, 2023: Journal of Clinical Medicine
#16
JOURNAL ARTICLE
M Amin Sharifi, Michael Wierer, Tan An Dang, Jelena Milic, Aldo Moggio, Nadja Sachs, Moritz von Scheidt, Julia Hinterdobler, Philipp Müller, Julia Werner, Barbara Stiller, Zouhair Aherrahrou, Jeanette Erdmann, Andrea Zaliani, Mira Graettinger, Jeanette Reinshagen, Sheraz Gul, Philip Gribbon, Lars Maegdefessel, Jürgen Bernhagen, Hendrik B Sager, Matthias Mann, Heribert Schunkert, Thorsten Kessler
BACKGROUND: The ADAMTS7 locus was genome-wide and significantly associated with coronary artery disease. Lack of the ECM (extracellular matrix) protease ADAMTS-7 (A disintegrin and metalloproteinase-7) was shown to reduce atherosclerotic plaque formation. Here, we sought to identify molecular mechanisms and downstream targets of ADAMTS-7 mediating the risk of atherosclerosis. METHODS: Targets of ADAMTS-7 were identified by high-resolution mass spectrometry of atherosclerotic plaques from Apoe-/- and Apoe-/- Adamts7-/- mice...
September 7, 2023: Circulation Research
#17
JOURNAL ARTICLE
Constantin Kuna, Nadine Wiedenmayer, Christian Bradaric, Antonia Presch, Felix Voll, Sebastian Kufner, Tareq Ibrahim, Heribert Schunkert, Karl-Ludwig Laugwitz, Salvatore Cassese, Adnan Kastrati, Jens Wiebe
BACKGROUND: Only few data is available for long-term outcomes of patients being treated for in-stent restenosis (ISR) in saphenous vein grafts (SVG). AIMS: Thus, the aim of this observational, retrospective study was to close this lack of evidence. METHODS: Between January 2007 and February 2021 a total of 163 patients with 186 ISR lesions located in SVG were treated at two large-volume centers in Munich, Germany. Endpoints of interest were all-cause mortality, target lesion revascularization (TLR) and target vessel myocardial infarction (TVMI)...
August 21, 2023: Catheterization and Cardiovascular Interventions
#18
JOURNAL ARTICLE
Shqipdona Lahu, Kristin Adler, Katharina Mayer, Ralph Hein-Rothweiler, Isabell Bernlochner, Gjin Ndrepepa, Stefanie Schüpke, Stefan Holdenrieder, Dario Bongiovanni, Karl-Ludwig Laugwitz, Heribert Schunkert, Meinrad Gawaz, Steffen Massberg, Adnan Kastrati, Götz Münch
BACKGROUND AND AIMS: Glycoprotein VI (GPVI) is the major platelet-specific collagen receptor. GPVI shedding with generation of soluble GPVI (sGPVI) is an endogenous feedback mechanism preventing platelet overstimulation. sGPVI has not been investigated in patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI), especially regarding its potential value as a predictor of ischemic and bleeding risk. METHODS: Baseline plasma sGPVI levels were available in 318 patients with CCS undergoing PCI...
August 17, 2023: Thrombosis and Haemostasis
#19
Moritz von Scheidt, Sabine Bauer, Angela Ma, Ke Hao, Thorsten Kessler, Baiba Vilne, Ying Wang, Chani J Hodonsky, Saikat K B Ghosh, Michal Mokry, Hua Gao, Kenji Kawai, Atsushi Sakamoto, Juliane Kaiser, Dario Bongiovanni, Julia Fleig, Lilith Oldenbuettel, Zhifen Chen, Aldo Moggio, Hendrik B Sager, Judith S Hecker, Florian Bassermann, Lars Maegdefessel, Clint L Miller, Wolfgang Koenig, Andreas M Zeiher, Stefanie Dimmeler, Matthias Graw, Christian Braun, Arno Ruusalepp, Nicholas J Leeper, Jason C Kovacic, Johan L M Björkegren, Heribert Schunkert
BACKGROUND: Leukocyte progenitors derived from clonal hematopoiesis of undetermined potential (CHIP) are associated with increased cardiovascular events. However, the prevalence and functional relevance of CHIP in coronary artery disease (CAD) are unclear, and cells affected by CHIP have not been detected in human atherosclerotic plaques. METHODS: CHIP mutations in blood and tissues were identified by targeted deep-DNA-sequencing (DNAseq: coverage >3,000) and whole-genome-sequencing (WGS: coverage >35)...
July 26, 2023: medRxiv
#20
JOURNAL ARTICLE
Yordi J van de Vegte, Ruben N Eppinga, M Yldau van der Ende, Yanick P Hagemeijer, Yuvaraj Mahendran, Elias Salfati, Albert V Smith, Vanessa Y Tan, Dan E Arking, Ioanna Ntalla, Emil V Appel, Claudia Schurmann, Jennifer A Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina Mononen, Kirsi Auro, Anne U Jackson, Lawrence F Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Müller-Nurasyid, Carolina Roselli, Weihua Zhang, Marcus E Kleber, Xiuqing Guo, Henry J Lin, Francesca Pavani, Tessel E Galesloot, Raymond Noordam, Yuri Milaneschi, Katharina E Schraut, Marcel den Hoed, Frauke Degenhardt, Stella Trompet, Marten E van den Berg, Giorgio Pistis, Yih-Chung Tham, Stefan Weiss, Xueling S Sim, Hengtong L Li, Peter J van der Most, Ilja M Nolte, Leo-Pekka Lyytikäinen, M Abdullah Said, Daniel R Witte, Carlos Iribarren, Lenore Launer, Susan M Ring, Paul S de Vries, Peter Sever, Allan Linneberg, Erwin P Bottinger, Sandosh Padmanabhan, Bruce M Psaty, Nona Sotoodehnia, Ivana Kolcic, David O Arnar, Daniel F Gudbjartsson, Hilma Holm, Beverley Balkau, Claudia T Silva, Christopher H Newton-Cheh, Kjell Nikus, Perttu Salo, Karen L Mohlke, Patricia A Peyser, Heribert Schunkert, Mattias Lorentzon, Jari Lahti, Dabeeru C Rao, Marilyn C Cornelis, Jessica D Faul, Jennifer A Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie Waldenberger, Moritz F Sinner, Konstantin Strauch, Graciela E Delgado, Kent D Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renée de Mutsert, Eco J C de Geus, Åsa Johansson, Peter K Joshi, Lars Lind, Andre Franke, Peter W Macfarlane, Kirill V Tarasov, Nicholas Tan, Stephan B Felix, E-Shyong Tai, Debra Q Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia Lindgren, Andrew P Morris, Olli T Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur Gudnason, Nicholas J Timpson, Alanna C Morrison, Patricia B Munroe, David P Strachan, Niels Grarup, Ruth J F Loos, Susan R Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif Groop, Nicholas J Wareham, Cornelia M van Duijn, Mary F Feitosa, Christopher J O'Donnell, Mika Kähönen, Markus Perola, Michael Boehnke, Sharon L R Kardia, Jeanette Erdmann, Colin N A Palmer, Claes Ohlsson, David J Porteous, Johan G Eriksson, Claude Bouchard, Susanne Moebus, Peter Kraft, David R Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kääb, Annette Peters, John C Chambers, Jaspal S Kooner, Winfried März, Jerome I Rotter, Andrew A Hicks, J Gustav Smith, Lambertus A L M Kiemeney, Dennis O Mook-Kanamori, Brenda W J H Penninx, Ulf Gyllensten, James F Wilson, Stephen Burgess, Johan Sundström, Wolfgang Lieb, J Wouter Jukema, Mark Eijgelsheim, Edward L M Lakatta, Ching-Yu Cheng, Marcus Dörr, Tien-Yin Wong, Charumathi Sabanayagam, Albertine J Oldehinkel, Harriette Riese, Terho Lehtimäki, Niek Verweij, Pim van der Harst
Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals 493 independent genetic variants in 352 loci, including 68 genetic variants outside previously identified resting heart rate associated loci...
August 2, 2023: Nature Communications
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