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heribert schunkert

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https://www.readbyqxmd.com/read/29644412/patent-foramen-ovale-closure-versus-medical-therapy-for-prevention-of-recurrent-cryptogenic-embolism-updated-meta-analysis-of-randomized-clinical-trials
#1
Brunilda Alushi, Alexander Lauten, Salvatore Cassese, Roisin Colleran, Stefanie Schüpke, Himanshu Rai, Heribert Schunkert, Bernhard Meier, Ulf Landmesser, Adnan Kastrati
BACKGROUND: We performed an updated meta-analysis of all randomized-controlled trials (RCTs) comparing patent foramen ovale (PFO) closure with medical therapy for prevention of recurrent ischemic stroke. METHODS AND RESULTS: We searched Medline, EMBASE, and Cochrane databases, and proceedings of international meetings for RCTs of patients with cryptogenic stroke and PFO comparing percutaneous PFO closure versus medical therapy for prevention of recurrent ischemic stroke...
April 11, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29643466/etidronate-prevents-dystrophic-cardiac-calcification-by-inhibiting-macrophage-aggregation
#2
Carolin Bauer, Olivier le Saux, Viola Pomozi, Redouane Aherrahrou, Rene Kriesen, Stephanie Stölting, Annett Liebers, Thorsten Kessler, Heribert Schunkert, Jeanette Erdmann, Zouhair Aherrahrou
Cardiovascular calcification is associated with high risk of vascular disease. This involves macrophage infiltration of injured vascular tissue and osteoclast-related processes. Splenic monocytes from mice, that are predisposed (C3H) or resistant (B6) to calcification, were isolated and differentiated in vitro with M-CSF to generate macrophages, which aggregate to form multinucleated (MN) cells in the presence of RANKL. MN cell formation was significantly decreased in monocytes from resistant compared with calcifying mice...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29617917/management-of-hypercalcaemia-induced-heart-failure-using-mechanical-circulatory-support
#3
Katharina Knoll, Volkhard Kurowski, Heribert Schunkert, Hendrik B Sager
Acute heart failure is associated with high morbidity and mortality. Heart failure is caused by various conditions, including electrolyte imbalances. We report a rare case of hypercalcaemia-induced acute heart failure complicated by cardiogenic shock. Mechanical circulatory support was used successfully in this patient until calcium homeostasis was restored.
March 30, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29617720/a-decade-of-genome-wide-association-studies-for-coronary-artery-disease-the-challenges-ahead
#4
Jeanette Erdmann, Thorsten Kessler, Loreto Munoz Venegas, Heribert Schunkert
In this review, we summarise current knowledge on the genetics of coronary artery disease, based on 10 years of genome-wide association studies. The discoveries began with individual studies using 200K single nucleotide polymorphism arrays and progressed to large-scale collaborative efforts, involving more than a hundred thousand people and up to 40 Mio genetic variants. We discuss the challenges ahead, including those involved in identifying causal genes and deciphering the links between risk variants and disease pathology...
March 30, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29601927/genetic-alterations-in-the-no-cgmp-pathway-and-cardiovascular-risk
#5
REVIEW
Jana Wobst, Heribert Schunkert, Thorsten Kessler
In the past ten years, several chromosomal loci have been identified by genome-wide association studies to influence the risk of coronary artery disease (CAD) and its risk factors. The GUCY1A3 gene encoding the α1 subunit of the soluble guanylyl cyclase (sGC) resides at one of these loci and has been strongly associated with blood pressure and CAD risk. More recently, further genes in the pathway encoding the endothelial nitric oxide synthase, the phosphodiesterases 3A and 5A, and the inositol 1,4,5-trisphosphate receptor I-associated protein (IRAG), i...
March 27, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29599097/high-sensitivity-cardiac-troponin-t-and-prognosis-in-patients-with-st-segment-elevation-myocardial-infarction
#6
Gjin Ndrepepa, Sebastian Kufner, Magdalena Hoyos, Yukinori Harada, Erion Xhepa, Julia Hieber, Salvatore Cassese, Massimiliano Fusaro, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati
BACKGROUND: Evidence on the use of high-sensitivity cardiac troponins (hs-cTn) to risk-stratify patients with ST-segment elevation myocardial infarction (STEMI) is limited. METHODS: We assessed the prognostic value of preprocedural (admission) and peak postprocedural hs-cTnT in 818 patients with STEMI treated with primary percutaneous coronary intervention (PPCI). Preprocedural and peak postprocedural hs-cTnT was measured. The primary outcome was 3-year all-cause mortality...
March 26, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29593584/utilization-of-mental-health-care-treatment-patterns-and-course-of-psychosocial-functioning-in-northern-german-coronary-artery-disease-patients-with-depressive-and-or-anxiety-disorders
#7
Anna Lisa Westermair, Anja Schaich, Bastian Willenborg, Christina Willenborg, Stefan Nitsche, Heribert Schunkert, Jeanette Erdmann, Ulrich Schweiger
Background: Comorbid mental disorders in patients with coronary artery disease (CAD) are common and associated with adverse somatic outcomes. However, data on utilization rates of mental health care and treatment efficiency are scarce and inconsistent, which we tried to remedy with the present preliminary study on Northern German CAD patients. Method: A total of 514 German CAD patients, as diagnosed by cardiac catheterization, were assessed using the Mini International Neuropsychiatric Interview and the Global Assessment of Functioning (GAF) scale...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29551701/predictors-of-need-for-permanent-pacemaker-implantation-and-conduction-abnormalities-with-a-novel-self-expanding-transcatheter-heart-valve
#8
Costanza Pellegrini, Oliver Husser, Won-Keun Kim, Andreas Holzamer, Thomas Walther, Tobias Rheude, Nicola Patrick Mayr, Teresa Trenkwalder, Michael Joner, Jonathan Michel, Fabian Chaustre, Adnan Kastrati, Heribert Schunkert, Christof Burgdorf, Michael Hilker, Helge Möllmann, Christian Hengstenberg
INTRODUCTION AND OBJECTIVES: The incidence of permanent pacemaker implantation (PPI) and new conduction abnormalities (CA) with the ACURATE neo (Symetis S.A., Eclubens, Switzerland) has not been studied in detail. We aimed to analyze their predictors, evaluating patient- and device-related factors, including implantation depth and device-to-annulus ratio (DAR). METHODS: Two analyses of a multicenter population were performed: new PPI in pacemaker-naive patients (n = 283), and PPI/new-CA in patients without prior CA or pacemaker (n = 232)...
March 15, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29537375/outcomes-of-patients-treated-with-ultrathin-strut-biodegradable-polymer-sirolimus-eluting-stents-versus-fluoropolymer-based-everolimus-eluting-stents-a-meta-analysis-of-randomized-trials
#9
Salvatore Cassese, Gjin Ndrepepa, Robert A Byrne, Sebastian Kufner, Anna Lena Lahmann, Nader Mankerious, Erion Xhepa, Karl-Ludwig Laugwitz, Heribert Schunkert, Massimiliano Fusaro, Adnan Kastrati, Michael Joner
AIMS: The ultrathin strut biodegradable-polymer sirolimus-eluting stent (SES) is a new-generation drug-eluting stent (DES) developed to improve the percutaneous treatment of patients with coronary artery disease. Here, we sought to investigate whether the performance of ultrathin strut biodegradable-polymer SES is superior to that of the benchmark thin-strut fluoropolymer-based everolimus-eluting stent (EES). METHODS AND RESULTS: We undertook a study-level meta-analysis of trials, in which patients receiving percutaneous coronary intervention (PCI) were randomly assigned to either SES or EES...
March 13, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29472232/genome-wide-association-and-functional-studies-identify-scml4-and-thsd7a-as-novel-susceptibility-genes-for-coronary-artery-disease
#10
Yang Li, Dao Wen Wang, Yundai Chen, Can Chen, Jian Guo, Shu Zhang, Zhijun Sun, Hu Ding, Yan Yao, Lei Zhou, Ke Xu, Chun Song, Fan Yang, Bin Zhao, Han Yan, Wen-Jing Wang, Chong Wu, Xiangfeng Lu, Xueli Yang, Jie Dong, Guyan Zheng, Shuhan Tian, Yanjun Cui, Lijuan Jin, Gangqiong Liu, Hanbin Cui, Shenghuang Wang, Feng Jiang, Changhua Wang, Jeanette Erdmann, Linyao Zeng, Shian Huang, Jianfeng Zhong, Yuehua Ma, Wenjiang Chen, Jianli Sun, Wei Lei, Shenghan Chen, Shaoqi Rao, Dongfeng Gu, Heribert Schunkert, Xiao-Li Tian
OBJECTIVE: The genetic contribution to coronary artery disease (CAD) remains largely unclear. We combined genetic screening with functional characterizations to identify novel loci and candidate genes for CAD. APPROACH AND RESULTS: We performed genome-wide screening followed by multicenter validation in 8 cohorts consisting of 21 828 participants of Han ethnicity and identified 3 novel intragenic SNPs, rs9486729 ( SCML4 ; odds ratio, 1.25; 95% CI, 1.17-1.34; P =3...
February 22, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29468355/incidental-findings-in-multislice-computed-tomography-prior-to-transcatheter-aortic-valve-implantation-frequency-clinical-relevance-and-outcome
#11
Teresa Trenkwalder, Anna Lena Lahmann, Magdalena Nowicka, Costanza Pellegrini, Tobias Rheude, N Patrick Mayr, Stephanie Voss, Sabine Bleiziffer, Rüdiger Lange, Michael Joner, Albert M Kasel, Adnan Kastrati, Heribert Schunkert, Oliver Husser, Martin Hadamitzky, Christian Hengstenberg
Multislice computed tomography (MSCT) has emerged as the mainstay in patients planned for transcatheter aortic valve implantation (TAVI). Incidental findings (IF) in MSCT are common. However, the exact incidence, clinical relevance and further consequences of IF are unclear and it is controversial whether IF adversely affect patients' outcome. We analyzed MSCT data of 1050 patients screened for TAVI between January 2011 and December 2014. Median follow-up of patients was 20 months. In total, 3194 IF were identified, which were classified into clinically non-relevant IF (2872, 90%) and clinically relevant IF (322, 10%)...
February 21, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29467471/network-analysis-of-coronary-artery-disease-risk-genes-elucidates-disease-mechanisms-and-druggable-targets
#12
Harri Lempiäinen, Ingrid Brænne, Tom Michoel, Vinicius Tragante, Baiba Vilne, Tom R Webb, Theodosios Kyriakou, Johannes Eichner, Lingyao Zeng, Christina Willenborg, Oscar Franzen, Arno Ruusalepp, Anuj Goel, Sander W van der Laan, Claudia Biegert, Stephen Hamby, Husain A Talukdar, Hassan Foroughi Asl, Gerard Pasterkamp, Hugh Watkins, Nilesh J Samani, Timo Wittenberger, Jeanette Erdmann, Heribert Schunkert, Folkert W Asselbergs, Johan L M Björkegren
Genome-wide association studies (GWAS) have identified over two hundred chromosomal loci that modulate risk of coronary artery disease (CAD). The genes affected by variants at these loci are largely unknown and an untapped resource to improve our understanding of CAD pathophysiology and identify potential therapeutic targets. Here, we prioritized 68 genes as the most likely causal genes at genome-wide significant loci identified by GWAS of CAD and examined their regulatory roles in 286 metabolic and vascular tissue gene-protein sub-networks ("modules")...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29464420/dexmedetomidine-versus-propofol-opioid-for-sedation-in-transcatheter-aortic-valve-implantation-patients-a-retrospective-analysis-of-periprocedural-gas-exchange-and-hemodynamic-support
#13
N Patrick Mayr, Gunther Wiesner, Pieter van der Starre, Alexander Hapfelmeier, Gertrud Goppel, Albert Markus Kasel, Christian Hengstenberg, Oliver Husser, Heribert Schunkert, Peter Tassani-Prell
PURPOSE: Different sedation regimens have been described for use during transfemoral transcatheter aortic valve implantation (tf-TAVI) for treatment in patients with severe aortic stenosis. The purpose of this study was to compare dexmedetomidine (DEX) with a combination of propofol-opioid (PO) with respect to periprocedural gas exchange and hemodynamic support. METHODS: Data from a cohort of patients sedated with either DEX or PO for tf-TAVI were retrospectively analyzed from a prospectively maintained TAVI registry...
February 20, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29385358/catheter-ablation-for-atrial-fibrillation-with-heart-failure
#14
RANDOMIZED CONTROLLED TRIAL
Nassir F Marrouche, Johannes Brachmann, Dietrich Andresen, Jürgen Siebels, Lucas Boersma, Luc Jordaens, Béla Merkely, Evgeny Pokushalov, Prashanthan Sanders, Jochen Proff, Heribert Schunkert, Hildegard Christ, Jürgen Vogt, Dietmar Bänsch
BACKGROUND: Mortality and morbidity are higher among patients with atrial fibrillation and heart failure than among those with heart failure alone. Catheter ablation for atrial fibrillation has been proposed as a means of improving outcomes among patients with heart failure who are otherwise receiving appropriate treatment. METHODS: We randomly assigned patients with symptomatic paroxysmal or persistent atrial fibrillation who did not have a response to antiarrhythmic drugs, had unacceptable side effects, or were unwilling to take these drugs to undergo either catheter ablation (179 patients) or medical therapy (rate or rhythm control) (184 patients) for atrial fibrillation in addition to guidelines-based therapy for heart failure...
February 1, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29366244/pseudoautosomal-region-1-and-predisposition-to-coronary-artery-disease
#15
Paraskevi Christofidou, Christopher P Nelson, Matthew Denniff, James Eales, Majid Nikpay, Christina Loley, Liming Qu, Mark Kleber, Alison Goodall, Francois Cambien, Robert Roberts, Heribert Schunkert, Winfried Marz, Muredach P Reilly, Jeanette Erdmann, Ruth McPherson, Inke R Konig, John R Thompson, Nilesh J Samani, Maciej Tomaszewski
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29366087/genetic-and-functional-interaction-of-the-coronary-artery-disease-risk-gene-adamts7-with-ldl-cholesterol
#16
Patrick Schindler, Lingyao Zeng, Simon Von Ameln, Jeanette Erdmann, Thorsten Kessler, Heribert Schunkert
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29306485/comparison-of-carbohydrate-antigen-125-and-n-terminal-pro-brain-natriuretic-peptide-for-risk-prediction-after-transcatheter-aortic-valve-implantation
#17
Tobias Rheude, Costanza Pellegrini, Hans Schmid, Teresa Trenkwalder, N Patrick Mayr, Michael Joner, Albert M Kasel, Stefan Holdenrieder, Julio Nunez, Juan Sanchis, Vicent Bodi, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
Elevated carbohydrate antigen 125 (CA125) and N-terminal pro-brain natriuretic peptide (NTproBNP) have been associated with adverse outcome after transcatheter aortic valve implantation (TAVI). This study performs a comparison of both biomarkers for prognosis after TAVI. The study includes 363 patients. The primary end point was all-cause death or readmission for worsening congestive heart failure within 1 year after TAVI, and this end point occurred in 16% of the population. The optimal cutoff to predict the primary end point was 18...
February 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29300853/vascular-response-to-percutaneous-coronary-intervention-with-biodegradable-polymer-vs-new-generation-durable-polymer-drug-eluting-stents-a-meta-analysis-of-optical-coherence-tomography-imaging-trials
#18
Salvatore Cassese, Erion Xhepa, Gjin Ndrepepa, Sebastian Kufner, Roisin Colleran, Daniele Giacoppo, Tobias Koppara, Nader Mankerious, Robert A Byrne, Karl-Ludwig Laugwitz, Heribert Schunkert, Massimiliano Fusaro, Adnan Kastrati, Michael Joner
Aims: Whether biodegradable-polymer drug-eluting stents (BP-DES) induce a vascular response at follow-up more favourable than that of new-generation durable-polymer drug-eluting stents (DP-DES) remains controversial. We sought to evaluate the vascular response to percutaneous coronary intervention (PCI) with BP-DES vs. new-generation DP-DES as assessed by optical coherence tomography (OCT) imaging at follow-up. Methods and results: We undertook a meta-analysis of aggregate data by searching electronic scientific databases for investigations of PCI-patients receiving BP-DES vs...
January 2, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29297708/determinants-of-elevated-carbohydrate-antigen-125-in-patients-with-severe-symptomatic-aortic-valve-stenosis-referred-for-transcatheter-aortic-valve-implantation
#19
Tobias Rheude, Costanza Pellegrini, Wibke Reinhard, Teresa Trenkwalder, Wolfgang Koenig, N Patrick Mayr, Michael Joner, Julio Núñez, Stefan Holdenrieder, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
PURPOSE: Elevated carbohydrate antigen 125 (CA125) predicts adverse outcome after transcatheter aortic valve implantation (TAVI). While known underlying pathophysiological mechanisms of elevated CA125 include serosal effusions and inflammatory stimuli, clinical determinants associated with elevated CA125 in patients referred for TAVI remain unknown. Therefore, we investigated clinical, laboratory and echocardiographic determinants of elevated CA125 in patients with severe aortic valve stenosis referred for TAVI...
January 15, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29248989/stratified-prevention-opportunities-and-limitations-report-on-the-1st-interdisciplinary-cardiovascular-workshop-in-augsburg
#20
Gregor Kirchhof, Josef Franz Lindner, Stephan Achenbach, Klaus Berger, Stefan Blankenberg, Heiner Fangerau, Henner Gimpel, Ulrich M Gassner, Jens Kersten, Dorothea Magnus, Herbert Rebscher, Heribert Schunkert, Stephan Rixen, Paulus Kirchhof
Sufficient exercise and sleep, a balanced diet, moderate alcohol consumption and a good approach to handle stress have been known as lifestyles that protect health and longevity since the Middle Age. This traditional prevention quintet, turned into a sextet by smoking cessation, has been the basis of the "preventive personality" that formed in the twentieth century. Recent analyses of big data sets including genomic and physiological measurements have unleashed novel opportunities to estimate individual health risks with unprecedented accuracy, allowing to target preventive interventions to persons at high risk and at the same time to spare those in whom preventive measures may not be needed or even be harmful...
March 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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