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https://www.readbyqxmd.com/read/29683929/18f-fdg-pet-ct-in-the-evaluation-of-cancer-cervix-where-do-we-stand-today
#1
Shanmuga S Palaniswamy, Chaitanya R Borde, Padma Subramanyam
The incidence of gynecological malignancies is on the rise partly because of the availability of screening programmes, awareness, higher technological advancements, and availability of better medical care. Early diagnosis of any malignancy leads to prompt treatment. Use of 18Fluorine-Fluorodeoxyglucose (F-FDG) PET/CT in the treatment and follow-up of patients with Ca cervix considerably improves patient management. The primary diagnosis of Ca cervix is made either by biopsy of a visible tumor on the cervix or by a cone biopsy of a nonvisible malignant cervical focus...
April 20, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29681770/compliance-with-bladder-protocol-during-concurrent-chemoradiation-for-cancer-of-the-cervix-and-its-impact-on-enteritis-a-prospective-observational-study
#2
Sweta Bandanatham, Janaki Manur Gururajachar, Mohan Kumar Somashekar
Aim: This prospective study aims to assess the compliance with bladder protocol and the correlation with enteritis during pelvic radiation. Background: Bladder protocol is routinely used for patients undergoing pelvic radiation to reduce radiation enteritis. It is very difficult to maintain constant volume especially in the last two weeks due to radiation enteritis and cystitis. Materials and methods: Histologically proven 35 cervical cancer patients treated with concurrent chemoradiation in a tertiary care center were the subjects of this prospective study...
March 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29676660/new-tailored-substituted%C3%A2-benzothiazole-schiff-base-cu-ii-zn-ii-antitumor-drug-entities-effect-of-substituents-on-dna-binding-profile-antimicrobial-and-cytotoxic-activity
#3
Siffeen Zehra, Mohammad Shavez Khan, Iqbal Ahmad, Farukh Arjmand
New tailored Cu(II) & Zn(II) metal-based antitumor drug entities were synthesized from substituted benzothiazole o‒vanillin Schiff base ligands. The complexes were thoroughly characterized by elemental analysis, spectroscopic studies {IR, 1 H & 13 C NMR, ESI-MS, EPR} and magnetic susceptibility measurements. The structure activity relationship (SAR) studies of benzothiazole Cu(II) & Zn(II) complexes having molecular formulas [C30 H22 CuN5 O7 S2 ], [C30 H20 Cl2 CuN5 O7 S2 ], [C30 H20 CuF2 N5 O7 S2 ], [C30 H22 N4 O4 S2 Zn], [C30 H20 Cl2 N4 O4 S2 Zn] and [C30 H20 F2 N5 O7 S2 Zn], with CT‒DNA were performed by employing absorption, emission titrations and hydrodynamic measurements...
April 20, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29673740/recent-intrauterine-device-use-and-the-risk-of-precancerous-cervical-lesions-and-cervical-cancer
#4
Sarah Averbach, Michael J Silverberg, Wendy Leyden, Karen Smith-McCune, Tina Raine-Bennett, George F Sawaya
OBJECTIVE: Understanding the effect of contraceptives on the development of precancerous lesions of the cervix and cervical cancer may provide information that is valuable to women in contraceptive decision-making. The purpose of this study was to evaluate the association between recent intrauterine device (IUD) use (by type) and cervical intraepithelial neoplasia 2, 3, adenocarcinoma in situ or cancer (CIN2+ or CIN3+). STUDY DESIGN: Case-control study of 17,559 women age 18-49 with incident CIN2+ cases and 5:1 age-matched, incidence-density selected controls (N=87,378) who were members of Kaiser Permanente Northern California Healthcare System from 1996-2014...
April 16, 2018: Contraception
https://www.readbyqxmd.com/read/29669936/engineered-t-cells-targeting-e7-mediate-regression-of-human-papillomavirus-cancers-in-a-murine-model
#5
Benjamin Y Jin, Tracy E Campbell, Lindsey M Draper, Sanja Stevanović, Bianca Weissbrich, Zhiya Yu, Nicholas P Restifo, Steven A Rosenberg, Cornelia L Trimble, Christian S Hinrichs
T cell receptor (TCR) T cell therapy is a promising cancer treatment modality. However, its successful development for epithelial cancers may depend on the identification of high-avidity TCRs directed against tumor-restricted target antigens. The human papillomavirus (HPV) E7 antigen is an attractive therapeutic target that is constitutively expressed by HPV+ cancers but not by healthy tissues. It is unknown if genetically engineered TCR T cells that target E7 can mediate regression of HPV+ cancers. We identified an HPV-16 E7-specific, HLA-A*02:01-restricted TCR from a uterine cervix biopsy from a woman with cervical intraepithelial neoplasia...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29668638/clinical-impact-of-boost-irradiation-to-pelvic-lymph-node-in-uterine-cervical-cancer-treated-with-definitive-chemoradiotherapy
#6
Kyu Hye Choi, Ji Yoon Kim, Dong Soo Lee, Yun Hee Lee, Sea-Won Lee, SooYoon Sung, Hee Hyun Park, Sei-Chul Yoon, Soo Young Hur, Jong-Sup Park, Yeon Sil Kim
The aim of this study was to analyze tumor control and clinical outcomes of patients with uterine cervical cancer treated by chemoradiotherapy according to pelvic lymph node (PLN) positivity and boost irradiation to PLN and to determine toxicities associated with boost irradiation.We retrospectively reviewed patients with uterine cervical cancer treated with chemoradiotherapy between March 2000 and April 2015. Clinical characteristics, failure pattern, and survival outcomes of patients with or without PLN metastasis and those with or without boost irradiation were analyzed...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667174/impact-of-prior-cancer-history-on-the-overall-survival-of-patients-newly-diagnosed-with-cancer-a-pan-cancer-analysis-of-the-seer-database
#7
Huaqiang Zhou, Yan Huang, Zeting Qiu, Hongyun Zhao, Wenfeng Fang, Yunpeng Yang, Yuanyuan Zhao, Xue Hou, Yuxiang Ma, Shaodong Hong, Ting Zhou, Yaxiong Zhang, Li Zhang
The population of cancer survivors with prior cancer is rapidly growing. Whether a prior cancer diagnosis interferes with outcome is unknown. We conducted a pan-cancer analysis to determine the impact of prior cancer history for patients newly diagnosed with cancer. We identified 20 types of primary solid tumors between 2004 to 2008 in the Surveillance, Epidemiology, and End Results (SEER) database. Demographic and clinicopathologic variables were compared by chi-squared test and t-test as appropriate. The propensity score-adjusted Kaplan-Meier method and Cox proportional hazards models were used to evaluate the impact of prior cancer on overall survival (OS)...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29665393/comparative-experimental-theoretical-studies-on-the-egfr-dimerization-under-the-effect-of-egf-egf-analogues-binding-highlighting-the-importance-of-egf-egfr-interactions-at-site-iii-interface
#8
Masomeh Mehrabi, Hamid Mahdiuni, Hassan Rasouli, Kamran Mansouri, Mohsen Shahlaie, Reza Khodarahmi
Epidermal growth factor receptors (EGFRs) and their cytoplasmic tyrosine kinases play significant roles in cell proliferation and signaling. All the members of the EGFR/ErbB family are primary goals for cancer therapy, particularly for tumors of breast, cervix, ovaries, kidney, esophagus, prostate and non-small-cell lung carcinoma and head and neck tumors. However, the therapeutic ability of accessible anti-ErbB agents is limited. Therefore, recognizing EGF analogues or small organic molecules with high affinity for the extracellular domain of the EGFR is a critical target on cancer research...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29663358/a-case-control-study-of-hiv-infection-and-cancer-in-the-era-of-antiretroviral-therapy-in-rwanda
#9
Tharcisse Mpunga, Ariana Znaor, F Regis Uwizeye, Aline Uwase, Cyprien Munyanshongore, Silvia Franceschi, Gary M Clifford
The aim of our study was to assess the association between HIV infection and cancer risk in Rwanda approximately a decade after the introduction of antiretroviral therapy (cART). All persons seeking cancer care at Butaro Cancer Center of Excellence (BCCOE) in Rwanda from 2012 to 2016 were routinely screened for HIV, prior to being confirmed with or without cancer (cases and controls, respectively). Cases were coded according to ICD-O-3 and converted to ICD10. Associations between individual cancer types and HIV were estimated using adjusted unconditional logistic regression...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29643933/human-papillomavirus-genome-variants-and-head-and-neck-cancers-a-perspective
#10
REVIEW
Jean-Damien Combes, Silvia Franceschi
Human papillomaviruses (HPV) cause infections that are responsible for diverse clinical manifestations from benign conditions to invasive cancer. As different HPV types are associated with variable pathogenic potential, minor genetic variations within a given high-risk HPV type might also be associated with distinct oncogenic capacities, through variable ability of persistence or risk of progression to precancer/cancer. Most recent HPV variant studies in the cervix using latest sequencing technology confirmed that minor changes in the HPV genome can have a major influence on carcinogenesis and have revealed key data that help better understand the carcinogenicity of HPV at a molecular level...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29628630/interfraction-variations-in-organ-filling-and-their-impact-on-dosimetry-in-ct-image-based-hdr-intracavitary-brachytherapy
#11
Ramya Rangarajan
Aim: Since anatomical and geometric variations occur with every fraction, planning, and dose optimization is necessary for every fraction of high-dose rate intracavitary brachytherapy of carcinoma cervix. In this study, we have tried to quantify the differences in doses to organs at risk (OAR) for each fraction of brachytherapy. Methods and Materials: One hundred and seventy computed tomography datasets of cervical cancer patients receiving intracavitary brachytherapy at our institution between January and April 2015 were analyzed...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29627691/selective-cytotoxic-and-genotoxic-activities-of-5-2-bromo-5-methoxybenzylidene-thiazolidine-2-4-dione-against-nci-h292-human-lung-carcinoma-cells
#12
Maria do D Rodrigues, Priscila B G S Santiago, Karla M R Marques, Valéria R A Pereira, Maria C A B de Castro, Jeanne C L L Cantalice, Teresinha G da Silva, Mônica L Adam, Silene C do Nascimento, Julianna F C de Albuquerque, Gardenia C G Militao
BACKGROUND: Thiazolidine-2,4-dione ring system is used as a pharmacophore to build various heterocyclic compounds aimed to interact with biological targets. In the present study, benzylidene-2,4-thiazolidinedione derivatives (compounds 2-5) were synthesized and screened against cancer cell lines and the genotoxicity and cytotoxicity of the most active compound (5) was investigated on normal and lung cancer cell line. METHODS: For in vitro cytotoxic screening, the MTT assay was used for HL60 and K562 (leukemia), MCF-7 (breast adenocarcinoma), HT29 (colon adenocarcinoma), HEp-2 (cervix carcinoma) and NCI-H292 (lung carcinoma) tumor cell lines and Alamar-blue assay was used for non-tumor cells (PBMC, human peripheral blood mononuclear cells) were used...
November 22, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29624947/the-need-for-societal-investment-to-improve-cervical-cancer-outcomes-in-nigeria-a-commentary
#13
Jonah Musa
Although cervical cancer is a preventable cancer with a well-known natural history, it remains a huge burden in developing countries of sub-Saharan Africa where organized cervical cancer screening services are lacking. Developed countries that have invested on providing organized screening programs have made substantial progress in reducing both incidence and mortality due to cervical cancer. Implementing evidence-based interventions such as human papillomavirus (HPV) vaccination of young girls, early detection and treatment of premalignant conditions of the cervix through conventional Pap cytology, HPV screening or visual aided inspection with acetic acid could significantly reduce incidence of new cases at population level...
December 2017: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/29622276/prospective-assessment-of-patient-reported-outcomes-in-gynecologic-cancer-patients-before-and-after-pelvic-exenteration
#14
Shannon D Armbruster, Charlotte C Sun, Shannon N Westin, Diane C Bodurka, Lois Ramondetta, Larissa A Meyer, Pamela T Soliman
OBJECTIVE: Pelvic exenteration (PE) is a surgical procedure associated with significant morbidity offered to select women with locally advanced or recurrent gynecologic cancers. This ongoing study examines an array of patient-reported outcomes and satisfaction with PE. METHODS: Since February 2009, prospectively enrolled participants completed questionnaires evaluating body image (BIS), depression (CESD), social support (DUFSS), symptoms (MDASI), sexual function (SAQ), functional status (SF-12), quality of life (The Stoma-QOL), satisfaction with decision (SWD) and an investigator-designed survey at baseline, 6, and 12months after PE...
April 2, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29620661/the-combination-of-cisplatin-and-topotecan-as-a-second-line-treatment-for-patients-with-advanced-recurrent-uterine-cervix-cancer
#15
Ji Young Moon, Ik-Chan Song, Young Bok Ko, Hyo Jin Lee
We retrospectively reviewed outcomes of treatments with cisplatin and topotecan in patients with previously-treated uterine cervix cancer.We analyzed the medical records of patients with advanced (stage IVB) or recurrent or persistent squamous or non-squamous cell carcinoma of the cervix, who were treated with cisplatin and topotecan as a second-line chemotherapy between January 2000 and December 2015. The patients were treated with a combination of cisplatin (50 mg/m for 1 day) and topotecan (0.75 mg/m for 3 days) once every 3 weeks...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29619426/genotyping-of-human-pappilomavirus-in-cervical-precancerous-lesion-and-squamous-cell-carcinoma-at-dr-soetomo-hospital-surabaya-indonesia
#16
Gondo Mastutik, Rahmi Alia, Alphania Rahniayu, Anny Setijo Rahaju, Nila Kurniasari, Suhartono Taat Putra
Background: Cervical cancer caused by human papilloma virus (HPV), is the second most common cancer for women. This cancer is distributed worldwide, with ~80% of cases are found in the developing countries. In Indonesia, data of HPV genotypes are still limited and do not represent all regions of the country. Thus, here we report genotyping of HPV samples collected from the Dr. Soetomo Hospital Surabaya Indonesia patients, in 2013. Materials and Method: A cross sectional study was performed using 68 paraffin blocks of low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), and squamous cell carcinoma (SCC) cervix...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29616661/shell-feature-a-new-radiomics-descriptor-for-predicting-distant-failure-after-radiotherapy-in-non-small-cell-lung-cancer-and-cervix-cancer
#17
Hongxia Hao, Zhiguo Zhou, Shulong Li, Genevieve Maquilan, Michael R Folkert, Puneeth Iyengar, Kenneth D Westover, Kevin Albuquerque, Fang Liu, Hak Choy, Robert D Timmerman, Lin Yang, Jing Wang
Distant failure is the main cause for human cancer-related mortalities. To develop a model for predicting distant failure in non-small cell lung cancer (NSCLC) and cervix caner (CC) patients, a shell feature, consisting of outer voxels around the tumor boundary, was constructed using pre-treatment positron emission tomography (PET) images from 48 NSCLC patients received stereotactic body radiation therapy (SBRT) and 52 CC patients underwent external beam radiation therapy and concurrent chemotherapy followed with high-dose-rate intracavitary brachytherapy...
April 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29611489/nanocarriers-for-the-effective-treatment-of-cervical-cancer-research-advancements-and-patent-analysis
#18
Nida Akhtar, Kamla Pathak
BACKGROUND: Cervical cancer being the cancer of cervix is caused by the aberrant cell growth that acquires an ability to spread/ invade to other body parts as well. It has been reported to be the second most commonest cause of death and cancer as well among women. Based on the severity of the disease, treatment aspect needs to be explored more in order to overcome the limitations acquired by conventional treatment. Recently, nanocarriers based drug delivery systems including liposomes, nanofibres, metallic NPs, polymeric NPs, dendrimers, polymeric micelles, antibody-drug conjugates etc...
April 2, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29609538/significance-of-cd133-positive-cells-in-four-novel-hpv-16-positive-cervical-cancer-derived-cell-lines-and-biopsies-of-invasive-cervical-cancer
#19
Shifa Javed, Bal Krishan Sharma, Swati Sood, Sanjeev Sharma, Rashmi Bagga, Shalmoli Bhattacharyya, Charan Singh Rayat, Lakhbir Dhaliwal, Radhika Srinivasan
BACKGROUND: Cervical cancer is a major cause of cancer-related mortality in women in the developing world. Cancer Stem cells (CSC) have been implicated in treatment resistance and metastases development; hence understanding their significance is important. METHODS: Primary culture from tissue biopsies of invasive cervical cancer and serial passaging was performed for establishing cell lines. Variable Number Tandem Repeat (VNTR) assay was performed for comparison of cell lines with their parental tissue...
April 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29605879/parsing-the-paradox-hispanic-mortality-in-the-us-by-detailed-cause-of-death
#20
Jill Anne McDonald, Leonard Joseph Paulozzi
US Hispanics are a disadvantaged population that paradoxically has lower mortality rates than non-Hispanic whites. We conducted a descriptive analysis of age-adjusted mortality rates for 113 causes of death for US Hispanics (USH) and US non-Hispanic whites (USNHW) during 1999-2015. All-cause, age-adjusted mortality rates per 100,000 were: 581.1 USH and 788.8 USNHW. Lower Hispanic mortality from cancer, heart disease, and respiratory disease accounted for almost all the all-cause mortality gap. USH rates were higher than USNHW rates for cancers of the stomach, liver, and cervix; diabetes mellitus; liver disease; and homicide...
March 31, 2018: Journal of Immigrant and Minority Health
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