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https://www.readbyqxmd.com/read/29458011/inflammatory-cytokines-induce-podoplanin-expression-at-the-tumor-invasive-front
#1
Akiko Kunita, Vanessa Baeriswyl, Claudia Meda, Erik Cabuy, Kimiko Takeshita, Enrico Giraudo, Andreas Wicki, Masashi Fukayama, Gerhard Christofori
Tumor invasion is a critical first step in the organismic dissemination of cancer cells and the formation of metastasis in distant organs, the most important prognostic factor and the actual cause of death in most of the cancer patients. We report here that the cell surface protein podoplanin (PDPN), a potent inducer of cancer cell invasion, is conspicuously expressed by the invasive front of squamous cell carcinomas (SCC) of the cervix in patients and in the transgenic HPV/E2 mouse model of cervical cancer...
February 16, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29449732/gastric-metastasis-from-cervix-carcer-a-case-report
#2
L De Cicco, F Crivelli, P Beretta, E Gjoni, A Merlotti, A Starace, G Marzaroli, F Pasta, T Zurleni, A Aguzzi, C Calandra, S Bracelli
Gastric metastasis by solid tumor cancer is a rare event. Concomitant metastases to other organs are frequent, so that this condition is often associated to a poor prognosis. Upper gastrointestinal bleeding and anemia are the most common presenting symptoms. We present the case of a 81 years old women previously treated for cervix carcinoma showing later a stomach metastasis. The patient is alive and disease free 39 months after salvage gastrectomy. A radical surgery in selected patients could be useful for symptom palliation and prolonged survival...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29449731/mixed-malignant-mullerian-tumor-with-neuroendocrine-features-in-an-irradiated-uterus-for-cervical-carcinoma-a-unique-association-a-morphological-immunohistochemisty-and-ultrastructural-study
#3
V G Vellone, B Spina, F Grillo, P Calamaro, F Sarocchi, P Sala, S Ferrero, E Fulcheri
Chemo-radiation represents an effective therapy for carcinoma of the uterine cervix. The endometrium may however receive a consistent dose of mutagenic radiations and patients may have an increased risk of secondary malignancies. Endometrial mixed malignant mullerian tumor (MMMT) is a rare, highly aggressive disease, and neuroendocrine features are even rarer. A 68 years old woman underwent radio-chemotherapy for a squamous cell carcinoma of the cervix. Follow up was uneventful until, eight years after radio-chemotherapy, imaging exams detected a diffuse enlargement of the uterine body...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29444073/projected-future-impact-of-hpv-vaccination-and-primary-hpv-screening-on-cervical-cancer-rates-from-2017-2035-example-from-australia
#4
Michaela T Hall, Kate T Simms, Jie-Bin Lew, Megan A Smith, Marion Saville, Karen Canfell
BACKGROUND: Many countries are transitioning from cytology-based to longer-interval HPV screening. Trials comparing HPV-based screening to cytology report an increase in CIN2/3 detection at the first screen, and longer-term reductions in CIN3+; however, population level year-to-year transitional impacts are poorly understood. We undertook a comprehensive evaluation of switching to longer-interval primary HPV screening in the context of HPV vaccination. We used Australia as an example setting, since Australia will make this transition in December 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29441934/implants-composed-of-digoxin-and-poly-%C3%AE%C2%B5-caprolactone-development-characterization-anti-proliferative-and-anti-angiogenic-activities
#5
F F Rodrigues, W R Braz, F B Perasoli, L G R Ferreira, L A de O Barbosa, G R Da Silva
Drug delivery systems could be applied to locally treat cervical cancer, thus preventing the drawbacks of conventional therapy. In this study, anti-proliferative and anti-angiogenic effects of digoxin incorporated into poly(ε-caprolactone) implants were evaluated, aiming at the local treatment of cervical cancer. Implants were characterized, and the in vitro release profile of digoxin was demonstrated. Anti-proliferative and anti-angiogenic activities of digoxin were investigated by using chorioallantoic membrane and human cervix carcinoma (HeLa) cells, respectively...
July 3, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441569/epidemiologic-associations-of-hpv-positive-oropharyngeal-cancer-and-pre-cancerous-cervical-lesions
#6
M M Rietbergen, A A J D van Bokhoven, B I Lissenberg-Witte, D A M Heideman, C R Leemans, R H Brakenhoff, E Bloemena
PURPOSE: Human papillomavirus (HPV)- induced oropharyngeal squamous cell carcinoma (OPSCC) is still increasing worldwide. We aimed to investigate if the HPV-prevalence of OPSCC in the Netherlands is rising as well, especially in female patients. In addition, we evaluated the association between HPV-positive OPSCC and suspicious Pap results of the cervix in these female patients. PATIENTS AND METHODS: Patients with OPSCC treated in the period 2000-2015 at the VU University Medical Center Amsterdam, were included (n=926)...
February 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29441095/off-line-magnetic-resonance-imaging-navigation-of-cervix-cancer-brachytherapy-in-patients-with-risk-factors-for-uterine-perforation
#7
Noora Mohammed Al-Hammadi, Suparna Halsnad Chandramouli, Rabih Hammoud, Primoz Petric
Purpose: There are no reports on pre-insertion identification of cervix cancer patients at risk for uterine perforation during brachytherapy (BT). Our aim was to assess the incidence of risk factors in our patient cohort, and assess feasibility of a novel technique of magnetic resonance imaging (MRI)-guided navigation for applicator insertion (NAI) in high-risk cases. Material and methods: All patients with locally advanced cervical cancer, treated with image guided adaptive BT at our department between October 2013 and June 2017 were considered for analysis...
December 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29434897/folate-deficiency-and-aberrant-dna-methylation-and-expression-of-fhit-gene-were-associated-with-cervical-pathogenesis
#8
Qiaoling Li, Ling Ding, Nan Jing, Chunliang Liu, Zuokai Yang, Fang Chen, Lifang Hou, Jintao Wang
Aberrant DNA methylation is a recognized feature in various types of human cancer, and folate has a vital role in the epigenetics of mammalian cells by supplying methyl groups for DNA methylation reactions. Fragile histidine triad (FHIT) is a tumor suppressor gene that is frequently silenced in cervical cancer (CC) and preneoplastic lesions. Promoter hypermethylation was previously observed in CC, and its epigenetic silencing has been observed at mRNA or protein levels. Changes in folate intake to modulate DNA methylation may be a mechanistic link to cancer, but this remains to be elucidated...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433826/cancer-cervix-establishing-an-evidence-based-strategy-an-experience-of-a-tertiary-care-centre-in-india
#9
Shyam Kishore Shrivastava, Shirley Lewis, Supriya Chopra Sastri, G Lavanya, Umesh Mahantshetty, Reena Engineer
Carcinoma cervix is a common cancer among Indian women. Evidence based management is essential for best practice in treatment of carcinoma cervix for its effective control. The current imaging system like CT, MRI and PET CT scans have contributed in identifying the patients for optimal treatment and delivering treatment accurately. For stages IB2 to IV, concurrent chemoradiation is advocated with improvement in overall survival proven with randomized trials. Brachytherapy is an integral part in the radiation treatment...
January 12, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29433700/a-literature-review-of-cervical-cancer-screening-in-transgender-men
#10
REVIEW
Kayla C Gatos
Most female-to-male (FTM) transgender men retain their cervixes and need comprehensive sexual health care, including cervical cancer screening. According to the literature, FTM individuals obtain cervical cancer screening less frequently and are less likely to be up to date on their Pap tests compared with cisgender women. Misinformation related to human papillomavirus and cervical cancer risk was noted for health care providers and FTM individuals. Absence of transgender-specific guidelines or trained health care providers presents barriers to cervical cancer screening for FTM individuals, and further research is indicated to develop comprehensive guidelines unique to the needs and experiences of this population...
February 2018: Nursing for Women's Health
https://www.readbyqxmd.com/read/29431861/non-steroidal-anti-inflammatory-agents-to-induce-regression-and-prevent-the-progression-of-cervical-intraepithelial-neoplasia
#11
REVIEW
Shannon M Grabosch, Osman M Shariff, C William Helm
BACKGROUND: This is an updated version of the original Cochrane review published in 2014, Issue 4. Cervical intraepithelial neoplasia (CIN) precedes the development of invasive carcinoma of the cervix. Current treatment of CIN is quite effective, but there is morbidity for the patient related to pain, bleeding, infection, cervical stenosis and premature birth in a subsequent pregnancy. Effective treatment with medications, rather than surgery, would be beneficial. OBJECTIVES: To evaluate the effectiveness and safety of non-steroidal anti-inflammatory agents (NSAIDs), including cyclooxygenase-2 (COX-2) inhibitors, to induce regression and prevent the progression of CIN...
February 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29430460/cancer-stem-cells-and-evolving-novel-therapies-a-paradigm-shift
#12
REVIEW
Sangeetha Vasudevaraj Naveen, Kumar Kalaivani
Accumulating evidence of stem-like cells/cancer stem cells (CSCs) has been gaining attention of cancer researchers over the last decade. Though many tumors harbor CSCs in their dedicated niches, identifying and exterminating those cells has proved to be difficult, due to their heterogenous nature, as the CSC phenotype vary substantially and may undergo reversible phenotypic changes. As a tumor propagation initiator, CSCs are considered as an exciting novel therapy for a better therapeutic outcome. This review discusses the major advances in the development of CSC-based therapies of most common cancers which includes lung, cervix and liver cancers...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29429992/srsf10-mediated-il1rap-alternative-splicing-regulates-cervical-cancer-oncogenesis-via-mil1rap-nf-%C3%AE%C2%BAb-cd47-axis
#13
Fei Liu, Miao Dai, Qinyang Xu, Xiaolu Zhu, Yang Zhou, Shuheng Jiang, Yahui Wang, Zhihong Ai, Li Ma, Yanli Zhang, Lipeng Hu, Qin Yang, Jun Li, Shujie Zhao, Zhigang Zhang, Yincheng Teng
High-risk human papillomavirus oncoproteins E6 and E7 are the major etiological factors of cervical cancer but are insufficient for malignant transformation of cervical cancer. Dysregulated alternative splicing, mainly ascribed to aberrant splicing factor levels and activities, contributes to most cancer hallmarks. However, do E6 and E7 regulate the expression of splicing factors? Does alternative splicing acts as an "accomplice" of E6E7 to promote cervical cancer progression? Here, we identified that the splicing factor SRSF10, which promotes tumorigenesis of cervix, was upregulated by E6E7 via E2F1 transcriptional activation...
February 12, 2018: Oncogene
https://www.readbyqxmd.com/read/29429800/definite-chemoradiotherapy-is-a-competent-treatment-option-in-figo-stage-ib2-cervical-cancer-compared-with-radical-surgery-neoadjuvant-chemotherapy
#14
He-Yuan Hsieh, Jin-Wen Huang, Chien-Hsing Lu, Jin-Ching Lin, Lily Wang
BACKGROUND: To compare the treatment outcomes of different treatment modalities for International Federation of Gynecology and Obstetrics (FIGO) stage IB2 cervical cancer. METHODS: From January 2002 to July 2016, 91 patients with FIGO stage IB2 squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma of the cervix were enrolled. All of them received one of the following treatment modalities, including intensity-modulated radiotherapy (IMRT) with concurrent platinum-based chemotherapy (CCRT group, n = 27), radical surgery with or without adjuvant treatment (RH group, n = 25), or neoadjuvant chemotherapy followed by radical surgery with or without adjuvant treatment (NACT group, n = 39)...
February 8, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29427781/retroperitoneal-laparoscopic-paraaortic-lymphadenectomy-in-paraaortical-staging-of-locally-advanced-cervical-cancer
#15
Daniel Vázquez-Vicente, Bárbara Fernández Del Bas, José García Villayzán, Javier Plaza Arranz, Luis Chiva
STUDY OBJECTIVE: The objective was to review/learn a surgical technique not very well known by gynecologic oncologists. DESIGN: Level of evidence: III SETTING: Review of a surgical technique with emphasis on the paraaortic sentinel lymph nodes using indocyanine green. INTERVENTION: The film features the following steps to perform the procedure: 1. Creating a retroperitoneal window. 2. What to do if the peritoneum is torn. 3. Finding the psoas muscle, right ureter, and common iliac artery...
February 7, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29426928/lamb3-mediates-metastatic-tumor-behavior-in-papillary-thyroid-cancer-by-regulating-c-met-akt-signals
#16
Seung-Nam Jung, Hyun Sil Lim, Lihua Liu, Jae Won Chang, Young Chang Lim, Ki Sang Rha, Bon Seok Koo
Laminin subunit beta-3 (LAMB3) encodes one of the three subunits of LM-332, a protein of the extracellular matrix secreted by cultured human keratinocytes. While LAMB3 is involved in the invasive and metastatic abilities of several tumor types, including those found in the colon, pancreas, lung, cervix, stomach, and prostate, its mechanism of action in thyroid cancer has not been investigated previously. Our results show that LAMB3 is up-regulated in papillary thyroid cancer, and that its suppression reduces cell migration/invasion via down-regulation of epithelial‒mesenchymal transition-associated proteins (N-cadherin, vimentin, slug) and inhibition of matrix metalloproteinase 9...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29426638/comparison-of-dosimetric-parameters-derived-from-whole-organ-and-wall-contours-for-bladder-and-rectum-in-cervical-cancer-patients-treated-with-intracavitary-and-interstitial-brachytherapy
#17
Rachel Gerber, Alexandra Rink, Jennifer Croke, Jette Borg, Akbar Beiki-Ardakani, Anthony Fyles, Michael Milosevic, Jason Xie, Harald Keller, Kathy Han
For volumes up to 2 cm3 of the bladder and possibly up to 5 cm3 of the rectum, doses computed from the whole organ were good estimates of the doses in the wall in cervix brachytherapy, and there were no significant differences between patients treated with or without interstitial needles.
February 6, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29423555/second-malignancies-after-hematopoietic-stem-cell-transplantation
#18
REVIEW
Ivetta Danylesko, Avichai Shimoni
Second malignancies are a rare but well-defined late complication after autologous and allogeneic hematopoietic stem-cell transplantation (SCT). Solid malignancies occur in up to 15% of patients 15 years after SCT with myeloablative conditioning, with no plateau in the incidence rates. They are responsible for 5-10% of late deaths after SCT. The incidence is increased with advanced age at SCT. The major risk factors are the use of total body irradiation, which is associated with adenocarcinomas and with chronic graft-versus-host disease which is associated with squamous cell cancers...
February 8, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29423520/cisplatin-chemoradiotherapy-vs-radiotherapy-in-figo-stage-iiib-squamous-cell-carcinoma-of-the-uterine-cervix-a-randomized-clinical-trial
#19
Shyamkishore Shrivastava, Umesh Mahantshetty, Reena Engineer, Supriya Chopra, Rohini Hawaldar, Vinod Hande, Rajendra A Kerkar, Amita Maheshwari, T S Shylasree, Jaya Ghosh, Jyoti Bajpai, Lavanya Gurram, Seema Gulia, Sudeep Gupta
Importance: The evidence for concurrent chemoradiotherapy (CT-RT) in International Federation of Gynecology and Obstetrics (FIGO) stage IIIB squamous cell carcinoma of the uterine cervix is not robust. This study reports the final results of a randomized clinical trial of concurrent cisplatin-based CT-RT and radiotherapy alone (RT) in women with FIGO stage IIIB squamous cell carcinoma of the uterine cervix. Objective: To investigate the benefit of concurrent CT-RT in FIGO stage IIIB squamous cell carcinoma of the uterine cervix...
February 8, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29422423/use-of-artesunate-in-non-malarial-indications
#20
REVIEW
A Raffetin, F Bruneel, C Roussel, M Thellier, P Buffet, E Caumes, S Jauréguiberry
INTRODUCTION: Artesunate and other artemisinin derivatives are used in various infectious and non-infectious diseases. We aimed to analyze available data on artesunate and artemisinin derivatives activity in humans and their potential clinical benefits in non-malarial indications. MATERIAL AND METHODS: Literature review performed on PubMed and the Cochrane Library databases using the PRISMA method. We analyzed studies published in English from January 2008 to August 2017 using the same indicators of drug efficacy...
February 5, 2018: Médecine et Maladies Infectieuses
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