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dengue hemorraghic

Jianfeng Dai, Wen Pan, Penghua Wang
BACKGROUND: Dengue virus (DENV) and West Nile virus (WNV), close siblings of the Flaviviridae family, are the causative agents of Dengue hemorraghic shock or West Nile meningoencephalitis respectively. Vaccines against these two flaviviruses are currently unavailable. Interferon- Stimulated Gene 15 (ISG15), encoding an ubiquitin-like protein, is significantly induced by type I interferons or viral infections. Its roles in viral infections, however, vary with viruses, being either anti- or pro-viral...
2011: Virology Journal
Joc C Tay, Philip Tan
We use probabilistic Boolean networks to simulate the pathogenesis of Dengue Hemorraghic Fever (DHF). Based on Chaturvedi's work, the strength of cytokine influences are modeled stochastically as inducement probabilities. We use an aggregated function approach to derive the DHF Infection Model. Two basins of attractors are observed with synchronous updating; the Null Infection cycle attractor shows an expected cross-regulation of Th1 and Th2 cytokines corresponding to the homeostasis of an uninfected person, while the DHF Infection attractor shows the onset of DHF...
2006: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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