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https://www.readbyqxmd.com/read/28102886/translational-research-in-surgical-oncology
#1
K Søreide, M Sund
No abstract text is available yet for this article.
January 19, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28074759/effektiv-dekomprimerende-hemikraniektomi-og-livet-derefter
#2
EDITORIAL
Grethe Andersen, Niels Sunde
No abstract text is available yet for this article.
January 9, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28072593/use-of-benzodiazepines-and-related-drugs-is-associated-with-a-risk-of-stroke-among-persons-with-alzheimer-s-disease
#3
Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Anna-Maija Tolppanen, Reijo Sund, Jari Tiihonen, Sirpa Hartikainen
The aim of our study was to investigate the risk of any, ischemic, and hemorrhagic stroke associated with incident benzodiazepine and related drug (BZDR) use among community-dwelling individuals with Alzheimer's disease (AD). Data from the MEDALZ cohort including all community-dwelling persons newly diagnosed with AD between 2005 and 2011 in Finland were utilized. Incident BZDR users were identified with a 1-year washout period for previous use. Persons with a previous stroke were excluded, resulting in a final study sample of 45 050 individuals...
January 7, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28070605/intensive-care-medicine-in-2050-managing-cardiac-arrest
#4
Alain Cariou, Jerry P Nolan, Kjetil Sunde
No abstract text is available yet for this article.
January 9, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28068991/multiple-lifestyle-behaviours-and-mortality-findings-from-a-large-population-based-norwegian-cohort-study%C3%A2-the-hunt-study
#5
Steinar Krokstad, Ding Ding, Anne C Grunseit, Erik R Sund, Turid Lingaas Holmen, Vegar Rangul, Adrian Bauman
BACKGROUND: Lifestyle risk behaviours are responsible for a large proportion of disease burden and premature mortality worldwide. Risk behaviours tend to cluster in populations. We developed a new lifestyle risk index by including emerging risk factors (sleep, sitting time, and social participation) and examine unique risk combinations and their associations with all-cause and cardio-metabolic mortality. METHODS: Data are from a large population-based cohort study in a Norway, the Nord-Trøndelag Health Study (HUNT), with an average follow-up time of 14...
January 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28060921/does-an-integrated-care-intervention-for-copd-patients-have-long-term-effects-on-quality-of-life-and-patient-activation-a-prospective-open-controlled-single-center-intervention-study
#6
Elena Titova, Øyvind Salvesen, Signe Berit Bentsen, Synnøve Sunde, Sigurd Steinshamn, Anne Hildur Henriksen
BACKGROUND: Implementation of the COPD-Home integrated disease management (IDM) intervention at discharge after hospitalizations for acute exacerbations of COPD (AECOPD) led to reduced hospital utilization during the following 24 months compared to the year prior to study start. AIMS: To analyze the impact of the COPD-Home IDM intervention on health related quality of life, symptoms of anxiety and depression, and the degree of patient activation during 24 months of follow-up and to assess the association between these outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28047451/su-f-i-05-dose-symmetry-for-ctdi-equivalent-measurements-with-limited-angle-cbct
#7
V Singh, S McKenney, P Sunde, W Feng, D Bakalyar
PURPOSE: CTDI measurements, useful for characterizing the x-ray output for multi-detector CT (MDCT), require a 360° rotation of the gantry; this presents a problem for cone beam CT (CBCT) due to its limited angular rotation. The purpose of this work is to demonstrate a methodology for overcoming this limited angular rotation so that CTDI measurements can also be made on CBCT systems making it possible to compare the radiation output from both types of system with a common metric. METHODS: The symmetry of the CTDI phantom allows a 360° CTDI measurement to be replaced with two 180° measurements...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032242/molecular-pathological-study-on-lrrc10-in-sudden-unexplained-nocturnal-death-syndrome-in-the-chinese-han-population
#8
Lei Huang, Shuangbo Tang, Yili Chen, Liyong Zhang, Kun Yin, Yeda Wu, Jinxiang Zheng, Qiuping Wu, Jonathan C Makielski, Jianding Cheng
Sudden unexplained nocturnal death syndrome (SUNDS) is a perplexing disorder to both forensic pathologists and clinic physicians. Clinical features of SUNDS survivors suggested that SUNDS is similar to Brugada syndrome (BrS). Leucine-rich repeat containing 10 (LRRC10) gene was a newly identified gene linked to dilated cardiomyopathy, a disease associated with sudden cardiac death. To investigate the prevalence and spectrum of genetic variants of LRRC10 gene in SUNDS and BrS, the coding regions of LRRC10 were genetically screened in 113 sporadic SUNDS victims (from January 2005 to December 2015, 30...
December 28, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28030863/real-world-clinical-practice-of-intensified-chemotherapies-for-metastatic-pancreatic-cancer-results-from-a-pan-european-questionnaire-study
#9
Nha Le, Alessio Vinci, Marvin Schober, Sebastian Krug, Muhammad A Javed, Thomas Kohlmann, Malin Sund, Albrecht Neesse, Georg Beyer
INTRODUCTION: Recently, FOLFIRINOX and gemcitabine + nab-paclitaxel have been introduced as a novel intensified chemotherapy regimen for patients with metastasized pancreatic cancer. This study aims to analyze the real-world clinical practice with FOLFIRINOX and gemcitabine + nab-paclitaxel across Europe. METHODS: Invitations to participate in an anonymous web-based questionnaire were sent via e-mail to 5,420 doctors in 19 European countries through the network of national gastroenterological, oncological, surgical and pancreatic societies as well as the European Pancreatic Club...
2016: Digestion
https://www.readbyqxmd.com/read/28019006/glucose-and-intermediary-metabolism-and-astrocyte-neuron-interactions-following-neonatal-hypoxia-ischemia-in-rat
#10
Eva Brekke, Hester Rijkje Berger, Marius Widerøe, Ursula Sonnewald, Tora Sund Morken
Neonatal hypoxia-ischemia (HI) and the delayed injury cascade that follows involve excitotoxicity, oxidative stress and mitochondrial failure. The susceptibility to excitotoxicity of the neonatal brain may be related to the capacity of astrocytes for glutamate uptake. Furthermore, the neonatal brain is vulnerable to oxidative stress, and the pentose phosphate pathway (PPP) may be of particular importance for limiting this kind of injury. Also, in the neonatal brain, neurons depend upon de novo synthesis of neurotransmitters via pyruvate carboxylase in astrocytes to increase neurotransmitter pools during normal brain development...
December 26, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/28011766/structural-insight-to-mutation-effects-uncover-a-common-allosteric-site-in-class-c-gpcrs
#11
Kasper Harpsøe, Michael W Boesgaard, Christian Munk, Hans Bräuner-Osborne, David E Gloriam
MOTIVATION: Class C G protein-coupled receptors (GPCRs) regulate important physiological functions and allosteric modulators binding to the transmembrane domain constitute an attractive and, due to a lack of structural insight, a virtually unexplored potential for therapeutics and the food industry. Combining pharmacological site-directed mutagenesis data with the recent class C GPCR experimental structures will provide a foundation for rational design of new therapeutics. RESULTS: We uncover one common site for both positive and negative modulators with different amino acid layouts that can be utilized to obtain selectivity...
December 22, 2016: Bioinformatics
https://www.readbyqxmd.com/read/27997187/understanding-of-cyclic-volatile-methyl-siloxane-fate-in-a-high-latitude-lake-is-constrained-by-uncertainty-in-organic-carbon-water-partitioning
#12
Ingjerd Sunde Krogseth, Michael John Whelan, Guttorm Normann Christensen, Knut Breivik, Anita Evenset, Nicholas Alexander Warner
Cyclic volatile methyl siloxanes (cVMS) are emitted to aquatic environments with wastewater effluents. Here, we evaluate the environmental behavior of three cVMS compounds (octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5) and dodecamethylcyclohexasiloxane (D6)) in a high latitude lake (Storvannet, 70°N 23°E), experiencing intermittent wastewater emissions and high latitude environmental conditions (low temperatures and seasonal ice cover). Measured cVMS concentrations in lake water were below detection limits in both March and June 2014...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27992820/gja1-gene-variations-in-sudden-unexplained-nocturnal-death-syndrome-in-the-chinese-han-population
#13
Qiuping Wu, Yeda Wu, Liyong Zhang, Jinxiang Zheng, Shuangbo Tang, Jianding Cheng
Sudden unexplained nocturnal death syndrome (SUNDS) is a conundrum to both forensic pathologists and physicians, more than 80% of which the molecular pathogenesis remains unclear. Reported studies on both clinical and genetic phenotypes suggest SUNDS is related to congenital and acquired arrhythmias. Recent researches have linked the mutations of gene gap junction alpha 1 (GJA1) with arrhythmogenic cardiac disorders. In the present study, we investigate the potential correlation between GJA1 gene variations and the occurrence of SUNDS...
December 9, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27965314/how-voter-turnout-varies-between-different-chronic-conditions-a-population-based-register-study
#14
Reijo Sund, Hannu Lahtinen, Hanna Wass, Mikko Mattila, Pekka Martikainen
BACKGROUND: While poor self-rated health is known to decrease an individual's propensity to vote, disaggregation of the components of health on turnout has thus far received only little attention. This study deepens on the understanding of such relationships by examining the association between chronic diseases and voting. METHODS: The study uses an individual-level register-based data set that contains an 11% random sample of the entire electorate in the 1999 Finnish parliamentary elections...
December 13, 2016: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/27964777/genetic-and-environmental-influences-on-adult-human-height-across-birth-cohorts-from-1886-to-1994
#15
Aline Jelenkovic, Yoon-Mi Hur, Reijo Sund, Yoshie Yokoyama, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Sari Aaltonen, Kauko Heikkilä, Sevgi Y Öncel, Fazil Aliev, Esther Rebato, Adam D Tarnoki, David L Tarnoki, Kaare Christensen, Axel Skytthe, Kirsten O Kyvik, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Tessa L Cutler, John L Hopper, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Wendy Cozen, Amie E Hwang, Thomas M Mack, Joohon Sung, Yun-Mi Song, Sarah Yang, Kayoung Lee, Carol E Franz, William S Kremen, Michael J Lyons, Andreas Busjahn, Tracy L Nelson, Keith E Whitfield, Christian Kandler, Kerry L Jang, Margaret Gatz, David A Butler, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Glen E Duncan, Dedra Buchwald, Catherine A Derom, Robert F Vlietinck, Ruth Jf Loos, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Hoe-Uk Jeong, Gary E Swan, Ruth Krasnow, Patrik Ke Magnusson, Nancy L Pedersen, Anna K Dahl-Aslan, Tom A McAdams, Thalia C Eley, Alice M Gregory, Per Tynelius, Laura A Baker, Catherine Tuvblad, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Paul Lichtenstein, Timothy D Spector, Massimo Mangino, Genevieve Lachance, Meike Bartels, Toos Cem van Beijsterveldt, Gonneke Willemsen, S Alexandra Burt, Kelly L Klump, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Robert F Krueger, Matt McGue, Shandell Pahlen, Robin P Corley, Jacob V B Hjelmborg, Jack H Goldberg, Yoshinori Iwatani, Mikio Watanabe, Chika Honda, Fujio Inui, Finn Rasmussen, Brooke M Huibregtse, Dorret I Boomsma, Thorkild I A Sørensen, Jaakko Kaprio, Karri Silventoinen
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged...
December 14, 2016: ELife
https://www.readbyqxmd.com/read/27910774/comparison-of-the-chemical-composition-and-bioactive-components-of-fruiting-bodies-and-submerged-cultured-mycelia-of-the-willow-bracket-medicinal-mushroom-phellinus-igniarius-agaricomycetes
#16
Huawei Zeng, Wenfeng Wang, Menghua Ma, Guohua Xu, Mei Ying-Jie, Jianfan Sund
Chemical compositions and bioactive ingredients of dried fruiting bodies from Phellinus igniarius (CGMCC no. 50095) (P1) and submerged culture of Ph. igniarius dried mycelia (P2) were investigated in this study. It was found that glutamic acid was regarded as a major amino acid in P1 (1.20%) and was approximately 2.55-fold higher than that in P2 (0.47%). Total amino acids in P1 (5.36%) were slightly higher than in P2 (4.09%). The amounts of iron, zinc, copper, and manganese in P1 were 1.96-3.42 times as high as those in P2, whereas potassium, sodium, and magnesium in P2 were almost 2...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27896131/case-report-5%C3%A2-year-follow-up-of-adult-late-onset-mitochondrial-encephalomyopathy-with-lactic-acid-and-stroke-like-episodes-melas
#17
Kiri Sunde, Patrick R Blackburn, Anvir Cheema, Jennifer Gass, Jessica Jackson, Sarah Macklin, Paldeep S Atwal
Mitochondrial encephalomyopathy with lactic acid and stroke-like episodes (MELAS) is a multisystem mitochondrial disorder that typically presents in childhood. We describe the follow-up of a patient who was diagnosed with late-onset MELAS at the age of 49. Her clinical course includes sensorineural hearing loss, seizures, and multiple episodes of stroke-like metabolic crises. Molecular genetic testing on whole blood revealed 31% heteroplasmy of a m.3243A > G variant in the mtDNA, the causative variant in approximately 80% of MELAS cases...
December 2016: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/27894557/reporting-helicopter-emergency-medical-services-in-major-incidents-a-delphi-study
#18
Sabina Fattah, Anne Siri Johnsen, Stephen J M Sollid, Torben Wisborg, Marius Rehn, Ákos Sóti, Anatolij Truhlář, Andreas J Krüger, Björn Gunnarsson, Dan Gryth, David Ohlén, Espen Fevang, Geir Arne Sunde, Ivo Breitenmoser, Jouni Kurola, Jouni Nurmi, Knut Fredriksen, Leif Rognås, Peter Temesvari, Søren Mikkelsen, Vidar Magnusson, Wolfgang Voelckel
OBJECTIVE: Research on helicopter emergency medical services (HEMS) in major incidents is predominately based on case descriptions reported in a heterogeneous fashion. Uniform data reported with a consensus-based template could facilitate the collection, analysis, and exchange of experiences. This type of database presently exists for major incident reporting at www.majorincidentreporting.net. This study aimed to develop a HEMS-specific major incident template. METHODS: This Delphi study included 17 prehospital critical care physicians with current or previous HEMS experience...
November 2016: Air Medical Journal
https://www.readbyqxmd.com/read/27885626/anaplerosis-for-glutamate-synthesis-in-the-neonate-and-in-adulthood
#19
Eva Brekke, Tora Sund Morken, Anne B Walls, Helle Waagepetersen, Arne Schousboe, Ursula Sonnewald
A central task of the tricarboxylic acid (TCA, Krebs, citric acid) cycle in brain is to provide precursors for biosynthesis of glutamate, GABA, aspartate and glutamine. Three of these amino acids are the partners in the intricate interaction between astrocytes and neurons and form the so-called glutamine-glutamate (GABA) cycle. The ketoacids α-ketoglutarate and oxaloacetate are removed from the cycle for this process. When something is removed from the TCA cycle it must be replaced to permit the continued function of this essential pathway, a process termed anaplerosis...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27866849/inter-observer-variation-in-delineating-the-coronary-arteries-as-organs-at-risk
#20
Anna-Karin Wennstig, Hans Garmo, Per Hållström, Petra Witt Nyström, Per Edlund, Carl Blomqvist, Malin Sund, Greger Nilsson
PURPOSE: To determine the inter-observer variation in delineating the coronary arteries as organs at risk (OAR) in breast cancer (BC) radiotherapy (RT) and how this variation affects the estimated coronary artery radiation dose. METHOD: Delineation of the left main and the left anterior descending coronary artery (LMCA and LAD), and the right coronary artery (RCA), by using the heart atlas by Feng et al., was performed by three radiation oncologists in 32 women who had received adjuvant RT for BC...
November 17, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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