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https://www.readbyqxmd.com/read/28814431/calprotectin-as-a-marker-of-inflammation-in-patients-with-early-rheumatoid-arthritis
#1
Maria Karolina Jonsson, Nina Paulshus Sundlisæter, Hilde Haugedal Nordal, Hilde Berner Hammer, Anna-Birgitte Aga, Inge Christoffer Olsen, Karl Albert Brokstad, Désirée van der Heijde, Tore K Kvien, Bjørg-Tilde Svanes Fevang, Siri Lillegraven, Espen A Haavardsholm
OBJECTIVES: Calprotectin is an inflammatory marker of interest in rheumatoid arthritis (RA). We evaluated whether the level of calprotectin was associated with disease activity, and if it was predictive of treatment response and radiographic progression in patients with early RA. METHODS: Plasma from disease-modifying antirheumatic drug (DMARD)-naïve patients with RA fulfilling 2010 American College of Rheumatology/European League Against Rheumatism classification criteria with symptom duration <2 years was analysed for calprotectin at baseline, and after 1, 3 and 12 months...
August 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28802250/a-population-based-study-of-abdominal-aortic-aneurysm-treatment-in-finland-2000-2014
#2
Matti T Laine, Sani J Laukontaus, Reijo Sund, Pekka S Aho, Ilkka Kantonen, Anders Albäck, Maarit Venermo
Background -In the event of rupture of an abdominal aortic aneurysm (AAA), mortality is very high. AAA prevalence and incidence of ruptures has been reported to be decreasing. The treatment of AAA has also undergone a change in recent decades with a shift towards endovascular aneurysm repair (EVAR). Our aim was to evaluate how these changes have affected the elective and emergency treatment of AAA and their results in Finland. Methods -All patients treated for AAA in Finland, a country with a population of 5...
August 11, 2017: Circulation
https://www.readbyqxmd.com/read/28793177/infants-with-prenatally-diagnosed-kidney-anomalies-have-an-increased-risk-of-urinary-tract-infections
#3
Maria Rasmussen, Lone Sunde, René Frydensbjerg Andersen, Olav Bjørn Petersen, Morten Smaerup Olsen
AIM: This study estimated the urinary tract infection (UTI) risk in a nationwide cohort of infants prenatally diagnosed with parenchymal kidney anomalies compared with a comparison cohort. METHODS: A Danish population-based nationwide cohort of fetuses diagnosed with parenchymal kidney anomalies between 2007 and 2012 had previously been identified. These were compared with fetuses without kidney anomalies who were prenatally scanned the same year. Live born infants were followed from birth until the diagnosis of UTI, emigration, death or two years of age...
August 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28780242/what-if-medical-abortion-becomes-the-main-or-only-method-of-first-trimester-abortion-a-roundtable-of-views
#4
Kevin Sunde Oppegaard, Margaret Sparrow, Paul Hyland, Francisca García, Cristina Villarreal, Aníbal Faúndes, Laura Miranda, Marge Berer
No abstract text is available yet for this article.
August 3, 2017: Contraception
https://www.readbyqxmd.com/read/28771556/common-starlings-sturnus-vulgaris-increasingly-select-for-grazed-areas-with-increasing-distance-to-nest
#5
Henning Heldbjerg, Anthony D Fox, Peder V Thellesen, Lars Dalby, Peter Sunde
The abundant and widespread Common Starling (Sturnus vulgaris) is currently declining across much of Europe due to landscape changes caused by agricultural intensification. The proximate mechanisms causing adverse effects to breeding Starlings are unclear, hampering our ability to implement cost-efficient agri-environmental schemes to restore populations to former levels. This study aimed to show how this central foraging farmland bird uses and selects land cover types in general and how use of foraging habitat changes in relation to distance from the nest...
2017: PloS One
https://www.readbyqxmd.com/read/28764750/risk-of-head-and-traumatic-brain-injuries-associated-with-antidepressant-use-among-community-dwelling-persons-with-alzheimer-s-disease-a-nationwide-matched-cohort-study
#6
Heidi Taipale, Marjaana Koponen, Antti Tanskanen, Piia Lavikainen, Reijo Sund, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen
BACKGROUND: Antidepressant use has been associated with an increased risk of falling, but no studies have been conducted on whether antidepressant use is associated with an increased risk of head injuries which often result from falling among older persons. The objective of this study was to investigate the risk of head and brain injuries associated with antidepressant use among community-dwelling persons with Alzheimer's disease. METHODS: A matched cohort study was conducted by comparing new antidepressant users (n = 10,910) with two matched nonusers (n = 21,820) in the MEDALZ study cohort...
August 1, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28760517/the-international-glossary-on-infertility-and-fertility-care-2017
#7
Fernando Zegers-Hochschild, G David Adamson, Silke Dyer, Catherine Racowsky, Jacques de Mouzon, Rebecca Sokol, Laura Rienzi, Arne Sunde, Lone Schmidt, Ian D Cooke, Joe Leigh Simpson, Sheryl van der Poel
STUDY QUESTION: Can a consensus and evidence-driven set of terms and definitions be generated to be used globally in order to ensure consistency when reporting on infertility issues and fertility care interventions, as well as to harmonize communication among the medical and scientific communities, policy-makers, and lay public including individuals and couples experiencing fertility problems? SUMMARY ANSWER: A set of 283 consensus-based and evidence-driven terminologies used in infertility and fertility care has been generated through an inclusive consensus-based process with multiple stakeholders...
July 28, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28754778/cancer-risk-and-survival-in-path_mmr-carriers-by-gene-and-gender-up-to-75-years-of-age-a-report-from-the-prospective-lynch-syndrome-database
#8
Pål Møller, Toni T Seppälä, Inge Bernstein, Elke Holinski-Feder, Paulo Sala, D Gareth Evans, Annika Lindblom, Finlay Macrae, Ignacio Blanco, Rolf H Sijmons, Jacqueline Jeffries, Hans F A Vasen, John Burn, Sigve Nakken, Eivind Hovig, Einar Andreas Rødland, Kukatharmini Tharmaratnam, Wouter H de Vos Tot Nederveen Cappel, James Hill, Juul T Wijnen, Mark A Jenkins, Kate Green, Fiona Lalloo, Lone Sunde, Miriam Mints, Lucio Bertario, Marta Pineda, Matilde Navarro, Monika Morak, Laura Renkonen-Sinisalo, Mev Dominguez Valentin, Ian M Frayling, John-Paul Plazzer, Kirsi Pylvanainen, Maurizio Genuardi, Jukka-Pekka Mecklin, Gabriela Moeslein, Julian R Sampson, Gabriel Capella
BACKGROUND: Most patients with path_MMR gene variants (Lynch syndrome (LS)) now survive both their first and subsequent cancers, resulting in a growing number of older patients with LS for whom limited information exists with respect to cancer risk and survival. OBJECTIVE AND DESIGN: This observational, international, multicentre study aimed to determine prospectively observed incidences of cancers and survival in path_MMR carriers up to 75 years of age. RESULTS: 3119 patients were followed for a total of 24 475 years...
July 28, 2017: Gut
https://www.readbyqxmd.com/read/28749335/evaluation-of-a-widely-used-culture-based-method-for-detection-of-livestock-associated-meticillin-resistant-staphylococcus-aureus-mrsa-denmark-and-norway-2014-to-2016
#9
Jesper Larsen, Marianne Sunde, Md Zohorul Islam, Anne Margrete Urdahl, Aina Steihaug Barstad, Anders Rhod Larsen, Carl Andreas Grøntvedt, Øystein Angen
We evaluated a widely used culture-based method for detection of livestock-associated meticillin-resistant Staphylococcus aureus (LA-MRSA) in samples collected from pigs and the environment inside pig stables in Denmark and Norway. Selective enrichment in tryptic soy broth containing cefoxitin and aztreonam led to a high ratio of false-negative results (26%; 57/221). On this basis, we recommend reconsidering the use of selective enrichment for detection of LA-MRSA in animal and environmental samples.
July 13, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28739660/a-gene-implicated-in-activation-of-retinoic-acid-receptor-targets-is-a-novel-renal-agenesis-gene-in-humans
#10
Patrick D Brophy, Maria Rasmussen, Mrutyunjaya Parida, Greg Bonde, Benjamin W Darbro, Xiaojing Hong, Jason C Clarke, Kevin A Peterson, James Denegre, Michael Schneider, Caroline R Sussman, Lone Sunde, Dorte L Lildballe, Jens Michael Hertz, Robert A Cornell, Stephen A Murray, John R Manak
Renal agenesis (RA) is one of the more extreme examples of congenital anomalies of the kidney and urinary tract (CAKUT). Bilateral renal agenesis is almost invariably fatal at birth, and unilateral renal agenesis can lead to future health issues including end stage renal disease. Genetic investigations have identified several gene variants which cause RA, including EYA1, LHX1, and WT1 However, whereas compound null mutations of genes encoding α and γ retinoic acid receptors (RARs) cause RA in mice, to date there have been no reports of variants in RAR genes causing RA in humans...
July 24, 2017: Genetics
https://www.readbyqxmd.com/read/28693491/hypoxia-and-hypotension-in-patients-intubated-by-physician-staffed-helicopter-emergency-medical-services-a-prospective-observational-multi-centre-study
#11
Geir Arne Sunde, Mårten Sandberg, Richard Lyon, Knut Fredriksen, Brian Burns, Karl Ove Hufthammer, Jo Røislien, Akos Soti, Helena Jäntti, David Lockey, Jon-Kenneth Heltne, Stephen J M Sollid
BACKGROUND: The effective treatment of airway compromise in trauma and non-trauma patients is important. Hypoxia and hypotension are predictors of negative patient outcomes and increased mortality, and may be important quality indicators of care provided by emergency medical services. Excluding cardiac arrests, critical trauma and non-trauma patients remain the two major groups to which helicopter emergency medical services (HEMS) are dispatched. Several studies describe the impact of pre-hospital hypoxia or hypotension on trauma patients, but few studies compare this in trauma and non-trauma patients...
July 11, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28679550/differences-in-genetic-and-environmental-variation-in-adult-bmi-by-sex-age-time-period-and-region-an-individual-based-pooled-analysis-of-40-twin-cohorts
#12
Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Yoon-Mi Hur, Wendy Cozen, Amie E Hwang, Thomas M Mack, Chika Honda, Fujio Inui, Yoshinori Iwatani, Mikio Watanabe, Rie Tomizawa, Kirsi H Pietiläinen, Aila Rissanen, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Maarit Piirtola, Sari Aaltonen, Sevgi Y Öncel, Fazil Aliev, Esther Rebato, Jacob B Hjelmborg, Kaare Christensen, Axel Skytthe, Kirsten O Kyvik, Judy L Silberg, Lindon J Eaves, Tessa L Cutler, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Yun-Mi Song, Sarah Yang, Kayoung Lee, Carol E Franz, William S Kremen, Michael J Lyons, Andreas Busjahn, Tracy L Nelson, Keith E Whitfield, Christian Kandler, Kerry L Jang, Margaret Gatz, David A Butler, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Glen E Duncan, Dedra Buchwald, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Hoe-Uk Jeong, Gary E Swan, Ruth Krasnow, Patrik Ke Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Tom A McAdams, Thalia C Eley, Alice M Gregory, Per Tynelius, Laura A Baker, Catherine Tuvblad, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Timothy D Spector, Massimo Mangino, Genevieve Lachance, S Alexandra Burt, Kelly L Klump, Jennifer R Harris, Ingunn Brandt, Thomas S Nilsen, Robert F Krueger, Matt McGue, Shandell Pahlen, Robin P Corley, Brooke M Huibregtse, Meike Bartels, Catharina Em van Beijsterveldt, Gonneke Willemsen, Jack H Goldberg, Finn Rasmussen, Adam D Tarnoki, David L Tarnoki, Catherine A Derom, Robert F Vlietinck, Ruth Jf Loos, John L Hopper, Joohon Sung, Hermine H Maes, Eric Turkheimer, Dorret I Boomsma, Thorkild Ia Sørensen, Jaakko Kaprio
Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m(2))], but factors modifying these variance components are poorly understood.Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity.Design: We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs)...
August 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28674058/a-novel-6-benzyl-ether-benzoxaborole-is-active-against-mycobacterium-tuberculosis-in-vitro
#13
Nipul Patel, Theresa O'Malley, Yong-Kang Zhang, Yi Xia, Bjorn Sunde, Lindsay Flint, Aaron Korkegian, Thomas R Ioerger, Jim Sacchettini, M R K Alley, Tanya Parish
We identified a novel 6-benzyl ether benzoxaborole with potent activity against Mycobacterium tuberculosis The compound had a minimum inhibitory concentration of 2 μM in liquid medium. The compound was also able to prevent growth on solid medium at 0.8 μM and was active against intracellular bacteria (IC50 = 3.6 μM) without cytotoxicity against eukaryotic cells (IC50 >100 μM). We isolated resistant mutants (MIC ≥100 μM), which had mutations in Rv1683, Rv3068c and Rv0047c.
July 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28669925/the-effect-of-tomatine-on-metastasis-related-matrix-metalloproteinase-mmp-activities-in-breast-cancer-cell-model
#14
Besra Özmen Yelken, Tuğçe Balcı, Sunde Yılmaz Süslüer, Çağla Kayabaşı, Çığır Biray Avcı, Petek Ballar Kırmızıbayrak, Cumhur Gündüz
Breast cancer is one of the most common malignancies in women and metastasis is the cause of morbidity and mortality in patients. In the development of metastasis, the matrix metalloproteinase (MMP) family has a very important role in tumor development. MMP-2 and MMP-9 work together for extracellular matrix (ECM) cleavage to increase migration. Tomatine is a secondary metabolite that has a natural defense role against plants, fungi, viruses and bacteria that are synthesized from tomato. In additıon, tomatine is also known that it breaks down the cell membrane and is a strong inhibitor in human cancer cells...
June 29, 2017: Gene
https://www.readbyqxmd.com/read/28645427/antidiabetic-medication-statins-and-the-risk-of-endometrioid-endometrial-cancer-in-patients-with-type-2-diabetes
#15
Reetta Arima, Mikko Marttila, Ari Hautakoski, Martti Arffman, Reijo Sund, Pirjo Ilanne-Parikka, Jenni Kangaskokko, Esa Läärä, Ulla Puistola, Marianne Hinkula
OBJECTIVE: To gain further evidence of an association between the incidence of endometrial cancer (EC) and the use of metformin, other antidiabetic medication (ADM) and statins in women with type 2 diabetes (T2D). METHODS: A retrospective cohort of 92,366 women with newly diagnosed T2D was obtained from a diabetes register (FinDM). 590 endometrioid ECs were observed during the follow-up time. Poisson regression was utilized to estimate the hazard ratios (HRs) with 95% confidence intervals (95% CIs) of the endometrioid EC in relation to the use of metformin, other oral ADM, insulin and statins...
June 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28627817/turbidimetric-determination-of-fecal-calprotectin-using-two-table-top-chemistry-analyzers-mindray-bs-200e-and-cobas%C3%A2-c111
#16
Aleksandra Mandic-Havelka, Tom Nilsen, Kathrin Sunde, Maria Norell, Lars O Hansson, Anders Larsson
BACKGROUND: Fecal calprotectin assays are widely used in diagnosis and monitoring of inflammatory bowel disease (IBD) in patients with suspected IBD. The most frequently used technique is ELISA and microtiter plates. Turbidimetric assays for analysis of fecal calprotectin can significantly reduce turnaround time. Many laboratories may be reluctant to run fecal samples on their large chemistry analyzers. The aim of this study was to evaluate fecal calprotectin particle enhanced turbidimetric immunoassay (PETIA) on smaller chemistry analyzers that could be dedicated for fecal samples...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28622881/discovery-of-%C3%AE-d-2-deoxy-2-dichlorouridine-nucleotide-prodrugs-as-potent-inhibitors-of-hepatitis-c-virus-replication
#17
Pedro Pinho, Genadiy Kalayanov, Hans Westerlind, Åsa Rosenquist, Horst Wähling, Christian Sund, Maria Almeida, Susana Ayesa, Jan Tejbrant, Paul Targett-Adams, Anders Eneroth, Annelie Lindqvist
Discovery of sofosbuvir has radically changed hepatitis C treatment and nucleoside/tide NS5B inhibitors are now viewed as one of the key components in combination therapies with other direct-acting antiviral agents. As part of our program to identify new nucleoside inhibitors of HCV replication, we now wish to report on the discovery of β-d-2'-deoxy-2'-dichlorouridine nucleotide prodrugs as potent inhibitors of HCV replication. Although, cytidine analogues have long been recognized to be metabolized to both cytidine and uridine triphosphates through the action of cytidine deaminase, uridine analogues are generally believed to produce exclusively uridine triphosphate...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28600297/the-premenopausal-breast-cancer-collaboration-a-pooling-project-of-studies-participating-in-the-national-cancer-institute-cohort-consortium
#18
Hazel B Nichols, Minouk J Schoemaker, Lauren B Wright, Craig McGowan, Mark N Brook, Kathleen M McClain, Michael E Jones, Hans-Olov Adami, Claudia Agnoli, Laura Baglietto, Leslie Bernstein, Kimberly A Bertrand, William J Blot, Marie-Christine Boutron-Ruault, Lesley Butler, Yu Chen, Michele M Doody, Laure Dossus, A Heather Eliassen, Graham G Giles, Inger T Gram, Susan E Hankinson, Judy Hoffman-Bolton, Rudolf Kaaks, Timothy J Key, Victoria A Kirsh, Cari M Kitahara, Woon-Puay Koh, Susanna C Larsson, Eiliv Lund, Huiyan Ma, Melissa A Merritt, Roger L Milne, Carmen Navarro, Kim Overvad, Kotaro Ozasa, Julie R Palmer, Petra H Peeters, Elio Riboli, Thomas E Rohan, Atsuko Sadakane, Malin Sund, Rulla M Tamimi, Antonia Trichopoulou, Lars Vatten, Kala Visvanathan, Elisabete Weiderpass, Walter C Willett, Alicja Wolk, Anne Zeleniuch-Jacquotte, Wei Zheng, Dale P Sandler, Anthony J Swerdlow
Breast cancer is a leading cancer diagnosis among premenopausal women around the world. Unlike rates in postmenopausal women, incidence rates of advanced breast cancer have increased in recent decades for premenopausal women. Progress in identifying contributors to breast cancer risk among premenopausal women has been constrained by the limited numbers of premenopausal breast cancer cases in individual studies and resulting low statistical power to subcategorize exposures or to study specific subtypes. The Premenopausal Breast Cancer Collaborative Group was established to facilitate cohort-based analyses of risk factors for premenopausal breast cancer by pooling individual-level data from studies participating in the United States National Cancer Institute Cohort Consortium...
June 9, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28581700/the-longitudinal-association-of-being-bullied-and-gender-with-suicide-ideations-self-harm-and-suicide-attempts-from-adolescence-to-young-adulthood-a-cohort-study
#19
Johannes Foss Sigurdson, Anne Mari Undheim, Jan Lance Wallander, Stian Lydersen, Anne Mari Sund
Longitudinal associations between being bullied during adolescence and suicide ideations, self-harm, and suicide attempts into young adulthood were examined. A large representative sample was examined in 1998 (N = 2,464, MA 13.7), 1999/2000, and 2012 to reassess the outcome measures. At all ages, bullied participants showed more suicide ideation, self-harm, and suicide attempts, regardless of gender. Bullied females showed a decrease in suicide ideation from adolescence to adulthood, while bullied males showed an increase in suicide attempts in the same time period...
June 5, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28570866/differentiated-effects-of-deep-brain-stimulation-and-medication-on-somatosensory-processing-in-parkinson-s-disease
#20
Kousik Sarathy Sridharan, Andreas Højlund, Erik Lisbjerg Johnsen, Niels Aagaard Sunde, Lars Gottfried Johansen, Sándor Beniczky, Karen Østergaard
OBJECTIVES: Deep brain stimulation (DBS) and dopaminergic medication effectively alleviate the motor symptoms in Parkinson's disease (PD) patients, but their effects on the sensory symptoms of PD are still not well understood. To explore early somatosensory processing in PD, we recorded magnetoencephalography (MEG) from thirteen DBS-treated PD patients and ten healthy controls during median nerve stimulation. METHODS: PD patients were measured during DBS-treated, untreated and dopaminergic-medicated states...
July 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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