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https://www.readbyqxmd.com/read/29155294/long-term-survival-in-patients-with-acute-myocardial-infarction-and-out-of-hospital-cardiac-arrest-a-prospective-cohort-study
#1
Kristin M Kvakkestad, Leiv Sandvik, Geir Øystein Andersen, Kjetil Sunde, Sigrun Halvorsen
AIM: To compare short- and long-term survival in patients admitted to hospital after acute myocardial infarction (AMI) with and without out-of-hospital cardiac arrest (OHCA). METHODS: Prospective cohort study of all AMI patients admitted to Oslo University Hospital Ulleval from September 1, 2005 to December 31, 2011. All-cause mortality was obtained from the Norwegian Cause of Death Registry with censoring date December 31, 2013. Cumulative survival was assessed with the Kaplan-Meier and the Life-table method...
November 16, 2017: Resuscitation
https://www.readbyqxmd.com/read/29154725/non-aneurysmal-subarachnoid-hemorrhage-when-is-a-second-angiography-indicated
#2
Asma Bashir, Ronni Mikkelsen, Leif Sørensen, Niels Sunde
Purpose Repeat imaging in patients with non-aneurysmal subarachnoid hemorrhage (NASAH) remains controversial. We aim to report our experience with NASAH with different hemorrhage patterns, and to investigate the need for further diagnostic workup to determine the underlying cause of hemorrhage. Method We conducted a retrospective analysis of all spontaneous SAH with an initial negative computed tomography (CT) with angiography (CTA) and/or digital subtraction angiography (DSA) from October 2011 through May 2017...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/29153733/antibacterial-activity-of-endodontic-sealers-against-planktonic-bacteria-and-bacteria-in-biofilms
#3
Vasileios Kapralos, Andreas Koutroulis, Dag Ørstavik, Pia Titterud Sunde, Håkon Valen Rukke
INTRODUCTION: The aim of this study was to investigate the antibacterial activity of 4 endodontic sealers against bacteria planktonic grown or in biofilms commonly detected from persistent and secondary endodontic infections. METHODS: The antibacterial activity of the sealers AH Plus, TotalFill BC sealer, RoekoSeal, and Guttaflow 2 was investigated for planktonic grown and 24-hour-old biofilms of Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus, and Streptococcus mutans...
November 15, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29141610/social-relations-and-healthcare-utilisation-among-middle-aged-and-older-people-study-protocol-for-an-implementation-and-register-based-study-in-denmark
#4
Anne Sophie Bech Mikkelsen, Rikke Lund, Maria Kristiansen
BACKGROUND: While previous research establishes an association between social relations, health and use of healthcare services among older people, how to implement this knowledge in real-life settings has received much less attention. This study will explore the relationship between social relations, health and use of healthcare services in a Danish mid-life population sample. In addition, the study will explore individual and contextual factors affecting the implementation of a group-based life story intervention aimed at establishing and strengthening social relations among older people at nursing homes in Denmark...
November 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29117321/the-international-glossary-on-infertility-and-fertility-care-2017
#5
Fernando Zegers-Hochschild, G David Adamson, Silke Dyer, Catherine Racowsky, Jacques de Mouzon, Rebecca Sokol, Laura Rienzi, Arne Sunde, Lone Schmidt, Ian D Cooke, Joe Leigh Simpson, Sheryl van der Poel
STUDY QUESTION: Can a consensus and evidence-driven set of terms and definitions be generated to be used globally in order to ensure consistency when reporting on infertility issues and fertility care interventions, as well as to harmonize communication among the medical and scientific communities, policy-makers, and lay public including individuals and couples experiencing fertility problems? SUMMARY ANSWER: A set of 283 consensus-based and evidence-driven terminologies used in infertility and fertility care has been generated through an inclusive consensus-based process with multiple stakeholders...
September 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29090422/health-related-quality-of-life-and-psychological-distress-in-young-adult-survivors-of-childhood-cancer-and-their-association-with-treatment-education-and-demographic-factors
#6
Janne F Halvorsen, Anne Mari Sund, Lonnie Zeltzer, Marian Ådnanes, Heidi Jensberg, Terje A Eikemo, Bendik Lund, Odin Hjemdal, Trude Reinfjell
PURPOSE: This study investigated health-related quality of life (HRQOL) and psychological distress among young adult (YA) survivors of childhood cancer and the association of these measures with treatment, education, and demographic factors ≥ 5 years post diagnosis. METHODS: Participants included cancer survivors (n = 91) recruited through the Cancer Registry of Norway (CRN) and healthy controls (n = 223) recruited from a student population. All participants completed self-report questionnaires, and the Pediatric Quality of Life Inventory (PedsQL™) 4...
October 31, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29078841/variation-in-normal-ear-temperature
#7
MULTICENTER STUDY
Märta Sund Levander, Ewa Grodzinsky
BACKGROUND: Variation in baseline ear temperature, taken in the unadjusted mode, has yet to be established in different age groups. Because normal body temperatures show large variations, the same may be expected for increased temperatures in fever. The aims were to study variations in normothermic body temperatures measured with an ear thermometer and to determine differences between actual and perceived body temperature during a febrile episode (referred to as difftemp) in apparently healthy children and adults...
October 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29077257/the-mitochondrial-membrane-protein-fgletm1-regulates-mitochondrial-integrity-production-of-endogenous-reactive-oxygen-species-and-mycotoxin-biosynthesis-in-fusarium-graminearum
#8
Guangfei Tang, Chengqi Zhang, Zhenzhen Ju, Shiyu Zheng, Ziyue Wen, Sunde Xu, Yun Chen, Zhonghua Ma
Deoxynivalenol (DON) is a mycotoxin produced in cereal crops infected with Fusarium graminearum. DON poses a serious threat to human and animal health and is a critical virulence factor. Various environmental factors including reactive oxygen species (ROS) have been shown to interfere with DON biosynthesis in this pathogen. The regulatory mechanisms of how ROS trigger DON production have been extensively investigated in F. graminearum. However, the role of the endogenous ROS generating system in DON biosynthesis is largely unknown...
October 27, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29064444/design-of-novel-water-soluble-and-highly-luminescent-europium-labels-with-potential-to-enhance-immunoassay-sensitivities
#9
Henri Sund, Kaj Blomberg, Niko Meltola, Harri Takalo
To meet the continual demands of more-sensitive immunoassays, the synthesis of novel luminescent Eu(III) chelate labels having similar substituted 4-(phenylethynyl)pyridine chromophores in three different chelate structure classes are reported. Significantly enhanced luminescence intensities were obtained, evidently caused by the intra-ligand charge transfer (ILCT) mediated sensitization, but the alternative ligands triplet state process cannot be ruled out. Based on the present study, even quite small changes on the chelate structure, and, especially, on the substituents' donor/acceptor strength on both ends of 4-(phenylethynyl)pyridine subunits have an unpredictable effect on the luminescence...
October 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29054569/cause-specific-mortality-in-endometrioid-endometrial-cancer-patients-with-type-2-diabetes-using-metformin-or-other-types-of-antidiabetic-medication
#10
R Arima, A Hautakoski, M Marttila, M Arffman, R Sund, P Ilanne-Parikka, J Kangaskokko, M Hinkula, U Puistola, E Läärä
AIM: To obtain further evidence of the association between metformin or other types of antidiabetic medication (ADM) and mortality from endometrial cancer (EC) and other causes of death in patients with endometrioid EC and type 2 diabetes (T2D). MATERIALS AND METHODS: A retrospective cohort of women with existing T2D and diagnosed with endometrioid EC from 1998 to 2011, obtained from a nationwide diabetes database (FinDM), were included in the study. Cumulative mortality from EC and that from other causes was described by using the Aalen-Johansen estimator...
October 17, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29046738/colorectal-cancer-incidence-in-path_mlh1-carriers-subjected-to-different-follow-up-protocols-a-prospective-lynch-syndrome-database-report
#11
Toni Seppälä, Kirsi Pylvänäinen, Dafydd Gareth Evans, Heikki Järvinen, Laura Renkonen-Sinisalo, Inge Bernstein, Elke Holinski-Feder, Paola Sala, Annika Lindblom, Finlay Macrae, Ignacio Blanco, Rolf Sijmons, Jacqueline Jeffries, Hans Vasen, John Burn, Sigve Nakken, Eivind Hovig, Einar Andreas Rødland, Kukatharmini Tharmaratnam, Wouter H de Vos Tot Nederveen Cappel, James Hill, Juul Wijnen, Mark Jenkins, Maurizio Genuardi, Kate Green, Fiona Lalloo, Lone Sunde, Miriam Mints, Lucio Bertario, Marta Pineda, Matilde Navarro, Monika Morak, Ian M Frayling, John-Paul Plazzer, Julian R Sampson, Gabriel Capella, Gabriela Möslein, Jukka-Pekka Mecklin, Pål Møller
BACKGROUND: We have previously reported a high incidence of colorectal cancer (CRC) in carriers of pathogenic MLH1 variants (path_MLH1) despite follow-up with colonoscopy including polypectomy. METHODS: The cohort included Finnish carriers enrolled in 3-yearly colonoscopy (n = 505; 4625 observation years) and carriers from other countries enrolled in colonoscopy 2-yearly or more frequently (n = 439; 3299 observation years). We examined whether the longer interval between colonoscopies in Finland could explain the high incidence of CRC and whether disease expression correlated with differences in population CRC incidence...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29043868/determinants-of-optimal-bowel-function-in-ileal-pouch-anal-anastomosis-physiological-differences-contributing-to-pouch-function
#12
Marie Louise Sunde, Petr Ricanek, Tom Øresland, Jørgen Jahnsen, Nazir Naimy, Arne Engebreth Færden
BACKGROUND: Variability in functional outcome after ileal-pouch anal anastomosis (IPAA) is to a large extent unexplained. The aim of this study was to perform multiple physiological and biochemical tests including an endoscopic examination with histology on IPAA patients with well and poorly functioning pouches to determine factors, or combinations thereof, contributing to functional outcome. METHODS: All patients with ulcerative colitis undergoing restorative proctocolectomy between 2000 and 2013 (N = 108) were interviewed using a pouch functioning score...
October 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29036432/copb2-is-essential-for-embryogenesis-and-hypomorphic-mutations-cause-human-microcephaly
#13
Andrew DiStasio, Ashley Driver, Kristen Sund, Milene Donlin, Ranjith M Muraleedharan, Shabnam Pooya, Beth Kline-Fath, Kenneth M Kaufman, Cynthia A Prows, Elizabeth Schorry, Biplab DasGupta, Rolf W Stottmann
Primary microcephaly is a congenital brain malformation characterized by a head circumference less than three standard deviations below the mean for age and sex and results in moderate to severe mental deficiencies and decreased lifespan. We recently studied two children with primary microcephaly in an otherwise unaffected family. Exome sequencing identified an autosomal recessive mutation leading to an amino acid substitution in a WD40 domain of the highly conserved Coatomer Protein Complex, Subunit Beta 2 (COPB2)...
September 19, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29025404/working-people-with-type-1-diabetes-in-the-finnish-population
#14
Pirjo Hakkarainen, Reijo Sund, Martti Arffman, Sari Koski, Vilma Hänninen, Leena Moilanen, Kimmo Räsänen
BACKGROUND: The incidence of type 1 diabetes is increasing worldwide. Since so little is known about work life of individuals with type 1 diabetes, we examined incidence and prevalence trends of type 1 diabetes among working-aged Finns. We also investigated the employment rate and how workers with type 1 diabetes perceive their health and work ability, and their intended retirement age. METHODS: We analyzed changes in the incidence, prevalence, and employment rate using nationwide multi-register-based FinDM data, and estimated a Self-Rated Health, Work Ability Score, and inquired about retirement intentions of 767 working individuals with type 1 diabetes in a cross-sectional survey...
October 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28988219/differences-in-levels-of-albumin-alt-ast-%C3%AE-gt-and-creatinine-in-frail-moderately-healthy-and-healthy-elderly-individuals
#15
Maria Edvardsson, Märtha Sund-Levander, Anna Milberg, Ewa Wressle, Jan Marcusson, Ewa Grodzinsky
BACKGROUND: Reference intervals are widely used as decision tools, providing the physician with information about whether the analyte values indicate ongoing disease process. Reference intervals are generally based on individuals without diagnosed diseases or use of medication, which often excludes elderly. The aim of the study was to assess levels of albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine and γ-glutamyl transferase (γ-GT) in frail, moderately healthy and healthy elderly indivuduals...
October 9, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28980809/elucidating-the-behavior-of-cyclic-volatile-methylsiloxanes-in-a-subarctic-freshwater-food-web-a-modeled-and-measured-approach
#16
Ingjerd S Krogseth, Emma Undeman, Anita Evenset, Guttorm N Christensen, Mick J Whelan, Knut Breivik, Nicholas A Warner
Cyclic volatile methylsiloxanes (cVMS) are used in personal care products and emitted to aquatic environments through wastewater effluents, and their bioaccumulation potential is debated. Here, a new bentho-pelagic version of the ACC-HUMAN model was evaluated for polychlorinated biphenyls (PCBs) and applied to cVMS in combination with measurements to explore their bioaccumulation behavior in a subarctic lake. Predictions agreed better with measured PCB concentrations in Arctic char (Salvelinus alpinus) and brown trout (Salmo trutta) when the benthic link was included than in the pelagic-only model...
November 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28975875/education-in-twins-and-their-parents-across-birth-cohorts-over-100-years-an-individual-level-pooled-analysis-of-42-twin-cohorts
#17
Karri Silventoinen, Aline Jelenkovic, Antti Latvala, Reijo Sund, Yoshie Yokoyama, Vilhelmina Ullemar, Catarina Almqvist, Catherine A Derom, Robert F Vlietinck, Ruth J F Loos, Christian Kandler, Chika Honda, Fujio Inui, Yoshinori Iwatani, Mikio Watanabe, Esther Rebato, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Yoon-Mi Hur, Hoe-Uk Jeong, Tessa L Cutler, John L Hopper, Andreas Busjahn, Kimberly J Saudino, Fuling Ji, Feng Ning, Zengchang Pang, Richard J Rose, Markku Koskenvuo, Kauko Heikkilä, Wendy Cozen, Amie E Hwang, Thomas M Mack, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Joohon Sung, Jina Kim, Jooyeon Lee, Sooji Lee, Tracy L Nelson, Keith E Whitfield, Qihua Tan, Dongfeng Zhang, Clare H Llewellyn, Abigail Fisher, S Alexandra Burt, Kelly L Klump, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Sarah E Medland, Nicholas G Martin, Grant W Montgomery, Patrik K E Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Robin P Corley, Brooke M Huibregtse, Sevgi Y Öncel, Fazil Aliev, Robert F Krueger, Matt McGue, Shandell Pahlen, Gonneke Willemsen, Meike Bartels, Catharina E M van Beijsterveldt, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Jennifer R Harris, Ingunn Brandt, Thomas S Nilsen, Finn Rasmussen, Per Tynelius, Laura A Baker, Catherine Tuvblad, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Margaret Gatz, David A Butler, Paul Lichtenstein, Jack H Goldberg, K Paige Harden, Elliot M Tucker-Drob, Glen E Duncan, Dedra Buchwald, Adam D Tarnoki, David L Tarnoki, Carol E Franz, William S Kremen, Michael J Lyons, José A Maia, Duarte L Freitas, Eric Turkheimer, Thorkild I A Sørensen, Dorret I Boomsma, Jaakko Kaprio
Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins)...
October 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28965036/health-related-quality-of-life-after-obstetric-intensive-care-admission-comparison-with-the-general-population
#18
Pia M Seppänen, Reijo T Sund, Tero I Ala-Kokko, Jukka T Uotila, Mika T Helminen, Tarja M Suominen
PURPOSE: To examine health-related quality of life (HRQoL) in obstetric patients after intensive care discharge, with comparison to age-appropriate reference values from the general Finnish female population. MATERIAL AND METHODS: Retrospective register-based study. Four multidisciplinary intensive care units at Finnish university hospitals participated. RESULTS: A total of 291 obstetric patient were admitted to the ICU, of whom 114 (39%) completed follow-up measurements...
September 21, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28947434/discrepancies-in-drug-histories-at-admission-to-gastrointestinal-surgery-internal-medicine-and-geriatric-hospital-wards-in-central-norway-a-cross-sectional-study
#19
Janne Kutschera Sund, Olav Sletvold, Trude Cecilie Mellingsæter, Randi Hukari, Torstein Hole, Per Einar Uggen, Petra Thiemann Vadset, Olav Spigset
OBJECTIVES: To compare discrepancies in drug histories among patients acutely admitted to different hospital wards, classify the discrepancies according to their potential clinical impact and identify appropriate selection criteria for patients that should be subject to a detailed drug history at admission. DESIGN: Cross-sectional study. SETTING: Two gastrointestinal surgery wards and one geriatric ward at St Olav's University Hospital in Trondheim and two general internal medicine wards at Ålesund Hospital in Ålesund, Norway...
September 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28942039/comparative-effect-of-imatinib-and-ponatinib-on-autophagy-and-mirnome-in-chronic-myeloid-leukemia
#20
Cagla Kayabasi, Tugce Balci Okcanoglu, Besra Ozmen Yelken, Aycan Asik, Sunde Yilmaz Susluer, Cigir Biray Avci, Guray Saydam, Cumhur Gunduz
BCR-ABL tyrosine kinase inhibitors (TKIs) are selective therapies for the patients with Chronic Myeloid Leukemia (CML). Imatinib and ponatinib have remarkable long-term efficacy on a major molecular response. Although TKI related induction of cytotoxicity and apoptosis have been clearly investigated in molecular levels, their comparative effect on autophagy and miRNome are largely unknown. This study aimed to investigate the involvement of alterations of miRNA expressions in CML progression, and how imatinib and ponatinib affect this process, by comparing CML, imatinib-resistant CML and leukemia stem cells (LSC)...
December 30, 2017: Gene
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