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https://www.readbyqxmd.com/read/28410549/evaluation-of-factors-influencing-antibody-reduction-for-development-of-antibody-drug-conjugates
#1
Meghdad Abdollahpour-Alitappeh, Majid Lotfinia, Sepand Razavi-Vakhshourpour, Saeed Jahandideh, Hamid Najminejad, Koushan Sineh Sepehr, Reza Moazami, Elnaz Shams, Mahdi Habibi-Anbouhi, Mohsen Abolhassani
Background: Reduction/alkylation is one of the leading strategies for the development of antibody drug conjugates (ADCs). Precise control of the reduction process would not only yield a defined number of free thiols per antibody but also result in development of more homogenous conjugates. Methods: In the present study, we investigated the effect of various dithiothreitol (DTT) concentrations, temperature conditions, and DTT exposure times on antibody reduction...
April 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28404523/structure-synthesis-and-biological-properties-of-the-pentacyclic-guanidinium-alkaloids
#2
REVIEW
Yunlong Shi, Yasamin Moazami, Joshua G Pierce
The pentacyclic guanidinium alkaloids (PGAs) are a family of marine natural products that possess a polycyclic guanidine-containing core and a long alkyl chain tethered spermidine-derived tail that is rarely observed in other natural products. These natural products exhibit potent activities on a wide range of organisms and therefore have attracted the attention of many synthetic chemists; however, the structure-activity relationships and mechanisms of action of PGAs remain largely elusive. Herein we summarize the structure, synthesis, toxicity and mechanisms of action of PGAs and highlight their potential as chemical probes and/or therapeutic leads...
March 12, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28395539/unlocking-the-box-basic-requirements-for-an-ideal-ventricular-assist-device-controller
#3
Alexander L Medvedev, Jamshid H Karimov, Barry D Kuban, David J Horvath, Nader Moazami, Kiyotaka Fukamachi
A modern ventricular assist device (VAD) system comprises an implantable rotary blood pump and external components located outside the patient's body: a wearable controller connected to the pump via a percutaneous cable, wearable rechargeable batteries, battery charger, alternating- and direct-current power supplies, and a hospital device to control and monitor the system. If the blood pump is the 'heart' of a VAD system, the controller is its 'brain.' The controller drives the pump's electrical motor; varies the pump speed or flow based on user commands or feedback signals; collects, processes, and stores data; performs self-diagnostics; transmits to and receives data from other system components, i...
April 19, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28391521/generating-pulsatility-by-pump-speed-modulation-with-continuous-flow-total-artificial-heart-in-awake-calves
#4
Kiyotaka Fukamachi, Jamshid H Karimov, Gengo Sunagawa, David J Horvath, Nicole Byram, Barry D Kuban, Raymond Dessoffy, Shiva Sale, Leonard A R Golding, Nader Moazami
The purpose of this study was to evaluate the effects of sinusoidal pump speed modulation of the Cleveland Clinic continuous-flow total artificial heart (CFTAH) on hemodynamics and pump flow in an awake chronic calf model. The sinusoidal pump speed modulations, performed on the day of elective sacrifice, were set at ±15 and ± 25% of mean pump speed at 80 bpm in four awake calves with a CFTAH. The systemic and pulmonary arterial pulse pressures increased to 12.0 and 12.3 mmHg (±15% modulation) and to 15...
April 8, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28388392/cardiogenic-shock-from-ecmo-to-impella-and-beyond
#5
REVIEW
Mehdi H Shishehbor, Nader Moazami, Michael Zhen-Yu Tong, Shinya Unai, W H Wilson Tang, Edward G Soltesz
For patients in cardiogenic shock, several devices can serve as a "bridge," ie, provide circulatory support and allow the patient to live long enough to recover or to receive a heart transplant or a long-term device. Options include an intra-aortic balloon pump, TandemHeart, Impella, extracorporeal membrane oxygenation (ECMO), and CentriMag. Which device to use depends on individual patient needs, local expertise, and anatomic and physiologic considerations.
April 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28351172/current-status-of-mechanical-circulatory-support-for-treatment-of-advanced-end-stage-heart-failure-successes-shortcomings-and-needs
#6
Gengo Sunagawa, Marijan Koprivanac, Jamshid H Karimov, Nader Moazami, Kiyotaka Fukamachi
Heart failure (HF) remains a major global burden in terms of morbidity and mortality. Despite advances in pharmacological and resynchronization device therapy, many patients worsen to end-stage HF. Although the gold-standard treatment for such patients is heart transplantation, there will always be a shortage of donor hearts. Areas covered: A left ventricular assist device (LVAD) is a valuable option for these patients as a bridge measure (to recovery, to candidacy for transplant, or to transplant itself) or as destination therapy...
May 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28324260/stroke-and-intracranial-hemorrhage-in-heartmate-ii-and-heartware-left-ventricular-assist-devices-a-systematic-review
#7
Sung M Cho, Nader Moazami, Jennifer A Frontera
BACKGROUND: Ischemic stroke and intracranial hemorrhage (ICH) following left ventricular assist device (LVAD) placement are major causes of morbidity. The incidence and mortality associated with these events stratified by device type have not been systematically explored. METHODS: A systematic review of PubMed was conducted from January 2007 through June 2016 for all English-language articles involving HeartMate II (HMII) and HeartWare LVAD patients. Ischemic stroke and/or ICH incidence (events per patient-year) and associated mortality rates were abstracted for each device type...
March 21, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28238150/moderate-hypothermia-technique-for-chronic-implantation-of-a-total-artificial-heart-in-calves
#8
Jamshid H Karimov, Patrick Grady, Martin Sinkewich, Gengo Sunagawa, Raymond Dessoffy, Nicole Byram, Nader Moazami, Kiyotaka Fukamachi
The benefit of whole-body hypothermia in preventing ischemic injury during cardiac surgical operations is well documented. However, application of hypothermia during in vivo total artificial heart implantation has not become widespread because of limited understanding of the proper techniques and restrictions implied by constitutional and physiological characteristics specific to each animal model. Similarly, the literature on hypothermic set-up in total artificial heart implantation has also been limited. Herein we present our experience using hypothermia in bovine models implanted with the Cleveland Clinic continuous-flow total artificial heart...
February 25, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28110971/risk-factors-mortality-and-timing-of-ischemic-and-hemorrhagic-stroke-with-left-ventricular-assist-devices
#9
Jennifer A Frontera, Randall Starling, Sung-Min Cho, Amy S Nowacki, Ken Uchino, M Shazam Hussain, Maria Mountis, Nader Moazami
BACKGROUND: Stroke is a major cause of mortality after left ventricular assist device (LVAD) placement. METHODS: Prospectively collected data of patients with HeartMate II (n = 332) and HeartWare (n = 70) LVADs from October 21, 2004, to May 19, 2015, were reviewed. Predictors of early (during index hospitalization) and late (post-discharge) ischemic and hemorrhagic stroke and association of stroke subtypes with mortality were assessed. RESULTS: Of 402 patients, 83 strokes occurred in 69 patients (17%; 0...
December 23, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28079760/a-31-year-old-man-with-a-ring-enhancing-brain-lesion
#10
Claire S Riley, Lisa A Roth, Jacinda B Sampson, Jai Radhakrishnan, Leal C Herlitz, Ari M Blitz, Golnaz Moazami
No abstract text is available yet for this article.
June 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28029574/the-axial-continuous-flow-blood-pump-bench-evaluation-of-changes-in-flow-associated-with-changes-of-inflow-cannula-angle
#11
Jamshid H Karimov, Michael Zhen-Yu Tong, Nicole Byram, Gengo Sunagawa, Raymond Dessoffy, Nader Moazami, Randall C Starling, Kiyotaka Fukamachi
BACKGROUND: Changes in the geometry of the HeartMate II (HMII) inflow cannula have been implicated in device thrombosis post-implant. The purpose of this in vitro study was to evaluate what effects changing the angle of the cannula in relation to the pump may have on pump flow and arterial pressure, under simulated inflow conditions. METHODS: The HMII with an inflow cannula was mounted on a mock loop consisting of a pulsatile pneumatic ventricle to simulate the native ventricle...
January 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27982020/intrabody-targeting-vascular-endothelial-growth-factor-receptor-2-mediates-downregulation-of-surface-localization
#12
E Alirahimi, A Ashkiyan, F Kazemi-Lomedasht, K Azadmanesh, M Hosseininejad-Chafi, M Habibi-Anbouhi, R Moazami, M Behdani
Angiogenesis is among the most important mechanisms that helps cancer cells to survive, grow and undergo metastasis. Therefore, inhibiting angiogenesis will suppress tumor growth. Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) are believed to be important players of angiogenesis. The goal of this study was to evaluate the success of a novel nanobody against VEGFR2 in tethering its target inside the endoplasmic reticulum and preventing its transport to the cell membrane. Nanobody sequence was cloned in a mammalian vector in fusion with green fluorescent protein and a KDEL retention signal...
December 16, 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27977855/effect-of-mta-particle-size-on-periapical-healing
#13
M Torabinejad, M Moazami, H Moaddel, J Hawkins, C Gustefson, H Faras, K Wright, S Shabahang
AIM: To examine the effect of reduction in MTA particle size on dento-alveolar and osseous healing in dogs. METHODOLOGY: Root canals of 24 mandibular premolars in four 2-year-old beagles were prepared and filled with gutta-percha and sealer. Two to four weeks later, during periapical surgery, the root-end cavity preparations in these teeth were filled with either grey ProRoot MTA or modified (reduced particle sizes with faster setting time) MTA. The animals were sacrificed 4 months later...
December 15, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/27892719/is-a-pulse-absolutely-necessary-during-cardiopulmonary-bypass
#14
REVIEW
Gengo Sunagawa, Marijan Koprivanac, Jamshid H Karimov, Nader Moazami, Kiyotaka Fukamachi
The benefits and disadvantages of pulsatility in mechanical circulatory support devices have been argued since before the first use of cardiopulmonary bypass (CPB) with a nonpulsatile pump. The debate over the superiority of either pulsatile or nonpulsatile perfusion during CPB persists, but recently, the evidence in favor of pulsatile perfusion during CPB is increasing. Complications associated with chronic nonpulsatile flow in patients implanted with left ventricular assist devices have renewed interest in generating pulsatility with these devices...
January 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27878837/thrombotic-depositions-on-right-impeller-of-double-ended-centrifugal-total-artificial-heart-in-vivo
#15
Jamshid H Karimov, David J Horvath, Shinji Okano, Mark Goodin, Gengo Sunagawa, Nicole Byram, Nader Moazami, Leonard A R Golding, Kiyotaka Fukamachi
The development of total artificial heart devices is a complex undertaking that includes chronic biocompatibility assessment of the device. It is considered particularly important to assess whether device design and features can be compatible long term in a biological environment. As part of the development program for the Cleveland Clinic continuous-flow total artificial heart (CFTAH), we evaluated the device for signs of thrombosis and biological material deposition in four animals that had achieved the intended 14-, 30-, or 90-day durations in each respective experiment...
November 23, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27729545/the-structure-kinetics-and-interactions-of-the-%C3%AE-carboxysomal-%C3%AE-carbonic-anhydrase-ccaa
#16
Leah D McGurn, Maryam Moazami-Goudarzi, Sean A White, Tannu Suwal, Beant Brar, Jason Q Tang, George S Espie, Matthew S Kimber
CcaA is a β-carbonic anhydrase (CA) that is a component of the carboxysomes of a subset of β-cyanobacteria. This protein, which has a characteristic C-terminal extension of unknown function, is recruited to the carboxysome via interactions with CcmM, which is itself a γ-CA homolog with enzymatic activity in many, but not all cyanobacteria. We have determined the structure of CcaA from Synechocystis sp. PCC 6803 at 1.45 Å. In contrast with the dimer-of-dimers organization of most bacterial β-CAs, or the loose dimer-of-dimers-of-dimers organization found in the plant enzymes, CcaA shows a well-packed trimer-of-dimers organization...
December 15, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27562526/examining-ubiquitinated-peptide-enrichment-efficiency-through-an%C3%A2-epitope-labeled-protein
#17
J Parker, Y Oh, Y Moazami, J G Pierce, P L Loziuk, R A Dean, D C Muddiman
Ubiquitination is a dynamic process that is responsible for regulation of cellular responses to stimuli in a number of biological systems. Previous efforts to study this post-translational modification have focused on protein enrichment; however, recent research utilizes the presence of the di-glycine (Gly-Gly) remnants following trypsin digestion to immuno-enrich ubiquitinated peptides. Monoclonal antibodies developed to the cleaved ubiquitin modification epitope, (tert-butoxycarbonyl) glycylglycine (Boc-Gly-Gly-NHS)(1), are used to identify the Gly-Gly signature...
November 1, 2016: Analytical Biochemistry
https://www.readbyqxmd.com/read/27556150/outcomes-of-adult-patients-with-small-body-size-supported-with-a-continuous-flow-left-ventricular-assist-device
#18
Sangjin Lee, Jason N Katz, Ulrich P Jorde, Nader Moazami, Ranjit John, Kartik S Sundareswaran, David J Farrar, O H Frazier
There is insufficient data on patients with small body size to determine if this should be considered a risk factor for continuous-flow left ventricular assist device (CF-LVAD) support. We sought to evaluate survival outcomes, adverse events, and functional status of CF-LVAD patients with body surface area (BSA) <1.5 m in a large national registry. Adults with BSA < 1.5 m (n = 128) implanted with a HeartMate II (HMII)-LVAD from the Interagency Registry for Mechanically Assisted Circulatory Support registry from April 2008 to December 2012 formed this cohort...
November 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27506349/impedometric-monitoring-of-the-behavior-of-the-supported-liquid-membrane-in-electromembrane-extraction-systems-an-insight-into-the-origin-of-optimized-experimental-parameters
#19
Jamil Mohammadi, Saied Saeed Hosseiny Davarani, Hamid Reza Moazami
Electromembrane extraction (EME) was carried out using a novel instrumentation capable of impedometric monitoring of the system during the extraction. This instrumentation involves a classical two-electrode assembly fed by two time-resolved potential functions, the first for the extraction of analyte and the second for obtaining the impedance information. The impedometric analysis of the system was achieved by Laplace transformation of the current recorded during the extraction. It has been shown that the obtained impedance information can be converted to very useful knowledge about time dependence of double layer capacitance, kinetics of analyte depletion, total permeability of the SLM and the effect of experimental parameters on system behavior...
August 31, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27436010/deciphering-the-wisent-demographic-and-adaptive-histories-from-individual-whole-genome-sequences
#20
Mathieu Gautier, Katayoun Moazami-Goudarzi, Hubert Levéziel, Hugues Parinello, Cécile Grohs, Stéphanie Rialle, Rafał Kowalczyk, Laurence Flori
As the largest European herbivore, the wisent (Bison bonasus) is emblematic of the continent wildlife but has unclear origins. Here, we infer its demographic and adaptive histories from two individual whole-genome sequences via a detailed comparative analysis with bovine genomes. We estimate that the wisent and bovine species diverged from 1.7 × 10(6) to 850,000 years before present (YBP) through a speciation process involving an extended period of limited gene flow. Our data further support the occurrence of more recent secondary contacts, posterior to the Bos taurus and Bos indicus divergence (∼150,000 YBP), between the wisent and (European) taurine cattle lineages...
November 2016: Molecular Biology and Evolution
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