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Tea polyphenols

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https://www.readbyqxmd.com/read/29157815/an-efflux-pump-mexab-oprm-of-pseudomonas-aeruginosa-is-associated-with-antibacterial-activity-of-epigallocatechin-3-gallate-egcg
#1
Rashmi Kanagaratnam, Rida Sheikh, Fahad Alharbi, Dong H Kwon
BACKGROUND: Pseudomonas aeruginosa is a notorious multidrug resistant nosocomial pathogen. An efflux pump (MexAB-OprM) is the main contributor to the multidrug resistance in clinical isolates of P. aeruginosa. Epigallocatechin-3-gallate (EGCG), a polyphenolic compound extracted from green tea, exhibits antibacterial activity. It is unclear that molecular details of the antibacterial activity of EGCG, EGCG-effect on antibiotic susceptibility, and clinical relevance of EGCG in bacteria...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29157222/comparative-proteomics-reveals-the-physiological-differences-between-winter-tender-shoots-and-spring-tender-shoots-of-a-novel-tea-camellia-sinensis-l-cultivar-evergrowing-in-winter
#2
Shengjie Liu, Jiadong Gao, Zhongjian Chen, Xiaoyan Qiao, Hualin Huang, Baiyuan Cui, Qingfeng Zhu, Zhangyan Dai, Hualing Wu, Yayan Pan, Chengwei Yang, Jun Liu
BACKGROUND: A recently discovered tea [Camellia sinensis (L.) O. Kuntze] cultivar can generate tender shoots in winter. We performed comparative proteomics to analyze the differentially accumulated proteins between winter and spring tender shoots of this clonal cultivar to reveal the physiological basis of its evergrowing character during winter. RESULTS: We extracted proteins from the winter and spring tender shoots (newly formed two leaves and a bud) of the evergrowing tea cultivar "Dongcha11" respectively...
November 20, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29152918/cosmeceutical-effect-of-ethyl-acetate-fraction-of-kombucha-tea-by-intradermal-administration-in-the-skin-of-aged-mice
#3
Nafiseh Pakravan, Elaheh Mahmoudi, Seyed-Ali Hashemi, Jamal Kamali, Reza Hajiaghayi, Mitra Rahimzadeh, Vajiheh Mahmoodi
BACKGROUND/PURPOSE: Natural ingredients have been always an interesting approach to prolong youthful appearance of skin. One of the natural compounds is Kombucha tea (KT), which has been mainly used as an energy drink in Asian countries for a long time. Previous reports indicated that it has pharmaceutical and favorable wound repairing effects. The beneficial properties of KT are thought to be mainly due to the presence of fermentation products such as flavonoids and other polyphenols with inhibition of hydrolytic and oxidative enzymes and anti-inflammatory effects...
November 19, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29146347/effect-of-tea-products-on-the-in-vitro-enzymatic-digestibility-of-starch
#4
Haihua Zhang, Yulan Jiang, Junxian Pan, Yangjun Lv, Jun Liu, Shikang Zhang, Yuejin Zhu
The importance of postprandial hyperglycemia in the treatment of diabetes has been recognized recently. Tea products, such as tea polyphenols (TP), epigallocatechin gallate (EGCG), matcha, and instant tea, were chosen as constituents of tea-flour food, aimed at regulating the release of glucose from starchy foods in the postprandial period. Six starches were chosen for internal composition analysis and hydrolysis studies in vitro. Corn starch, wheat starch, and lily root flour appeared to have higher resistant starch content, slower digestion profiles, and lower kinetic constants, implying sustained release of glucose in the gastrointestinal tract...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29141540/polyphenols-antioxidants-and-the-sympathetic-nervous-system
#5
Rosa Maria Bruno, Lorenzo Ghiadoni
BACKGROUND: A high dietary intake of polyphenols has been associated with a reduced cardiovascular mortality, due to their antioxidant properties. However, growing evidence suggests that counteracting oxidative stress in cardiovascular disease might also reduce sympathetic nervous system overactivity. METHODS: This article reviews the most commonly used techniques to measure sympathetic activity in humans; the role of sympathetic activation in the pathophysiology of cardiovascular diseases; current evidence demonstrating that oxidative stress is involved in the regulation of sympathetic activity and how antioxidants and polyphenols might counteract sympathetic overactivity, particularly focusing on preliminary data from human studies...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29137307/reversal-of-5-fluorouracil-resistance-by-egcg-is-mediate-by-inactivation-of-tfap2a-vegf-signaling-pathway-and-down-regulation-of-mdr-1-and-p-gp-expression-in-gastric-cancer
#6
Hongsheng Tang, Lisi Zeng, Jiahong Wang, Xiangliang Zhang, Qiang Ruan, Jin Wang, Shuzhong Cui, Dinghua Yang
The effect of 5-fluorouracil (5-FU) chemotherapy for gastric cancer (GC) is limited by drug-resistance. To conquer this drug-resistance, various treatments including combination therapy have been used, but the overall survival has not been improved yet. In our current study, 5-FU resistant GC cells, SGC7901/FU and MGC803/FU, were established by long term exposure to 5-FU, and the proliferation capability of these resistant cells was verified to be reduced. The drug related proteins, MDR1 and P-gp were up-regulated in resistant cells compared to the parental cells...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134218/antioxidant-and-anti-inflammatory-properties-of-ilex-guayusa-tea-preparations-a-comparison-to-camellia-sinensis-teas
#7
Madelein D Pardau, Andreia S P Pereira, Zeno Apostolides, June C Serem, Megan J Bester
Ilex guayusa tea preparations are now commercially available as Runa tea. Little is known regarding the antioxidant and anti-inflammatory bioactivities of this tea. The I. guayusa teas had a total polyphenolic content between 54.39 and 67.23 mg GAE per g dry mass and peroxyl radical scavenging capacities between 1773.41 and 2019 μmol TE per g dry mass, nearly half of that for the Camellia sinensis teas. The I. guayusa teas afforded 60-80% protection from oxidative stress in the Caco-2 cellular antioxidant assay, comparable to the C...
November 14, 2017: Food & Function
https://www.readbyqxmd.com/read/29131612/functional-characterization-of-epitheaflagallin-3-o-gallate-generated-in-laccase-treated-green-tea-extracts-in-the-presence-of-gallic-acid
#8
Nobuya Itoh, Junji Kurokawa, Yasuhiro Isogai, Masaru Ogasawara, Takayuki Matsunaga, Tutomu Okubo, Yuji Katsube
Epitheaflagallin (ETFG) and epitheaflagallin 3-O-gallate (ETFGg) are minor polyphenols in black tea extract that are enzymatically synthesized from epigallocatechin (EGC) and epigallocatechin gallate (EGCg), respectively, in green tea extract via laccase oxidation in the presence of gallic acid. The constituents of laccase-treated green tea extract in the presence of gallic acid are thus quite different from those of non-laccase-treated green tea extract: EGC and EGCg are present in lower concentrations, and ETFG and ETFGg are present in higher concentrations...
November 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29120758/antioxidant-capacity-and-major-polyphenol-composition-of-teas-as-affected-by-geographical-location-plantation-elevation-and-leaf-grade
#9
Chuang Zhang, Claire Li-Chieh Suen, Chao Yang, Siew Young Quek
Tea polyphenols have been a topic of discussion due to their health benefits. Nevertheless, detailed studies on the antioxidant capacity and polyphenol contents of teas in relation to factors including geographical locations, plantation elevations and leaf grades have been limited. In this study, 53 tea samples were analysed to determine the individual and total catechin and theaflavin contents by HPLC and the total antioxidant capacity by Oxygen Radical Absorbance Capacity (ORAC) methods. Results show that the polyphenol (catechins and theaflavins) contents were significantly influenced by plantation location...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29119919/polyphenols-and-microvascular-function-in-humans-a-systematic-review
#10
Kirsty A Woodward, Richard Draijer, Dick H J Thijssen, David A Low
BACKGROUND: Polyphenol-rich dietary sources are acknowledged to have potential cardiovascular health benefits, particularly in reducing cardiovascular disease risk. METHODS: This systematic review sought to determine the effect of polyphenol-rich foods and beverages upon microvascular function, which is of considerable importance in its contribution towards the pathophysiology of microvascular-related complications but also in the future development of (macro-vessel) cardiovascular disease...
November 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29119790/green-tea-polyphenols-decrease-strecker-aldehydes-and-bind-to-proteins-in-lactose-hydrolyzed-uht-milk
#11
Therese Jansson, Valentin Rauh, Bente P Danielsen, Mahesha M Poojary, Sandra S Waehrens, Wender L P Bredie, John Sørensen, Mikael A Petersen, Colin A Ray, Marianne N Lund
The effect of epigallocatechin gallate enriched green tea extract (GTE) on flavor, Maillard reactions and protein modifications in lactose-hydrolyzed (LH) ultrahigh temperature (UHT) processed milk was examined during storage at 40 °C for up to 42 days. Addition of GTE inhibited the formation of Strecker aldehydes by up to 95% compared to control milk, and the effect was similar when GTE was added either before or after UHT treatment. Release of free amino acids, caused by proteolysis, during storage was also decreased in GTE-added milk either before or after UHT treatment compared to control milk...
November 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29118865/protective-effects-of-tea-polyphenols-and-%C3%AE-carotene-against-%C3%AE-radiation-induced-mutation-and-oxidative-stress-in-drosophila-melanogaster
#12
Isha Nagpal, Suresh K Abraham
Background: The commonly consumed antioxidants β-carotene and tea polyphenols were used to assess their protective effects against γ-radiation induced sex-linked recessive lethal (SLRL) mutation and oxidative stress in Drosophila melanogaster. Third instar larvae and adult males of wild-type Oregon-K (ORK) were fed on test agents for 24 and 72 h respectively before exposure to 10Gy γ-irradiation. The treated/control flies were used to assess the induction of SLRLs. We also evaluated antioxidant properties of these phytochemicals in the third instar larvae...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/29113421/oxidative-stress-induced-diseases-and-tea-polyphenols
#13
REVIEW
Xiangbing Mao, Changsong Gu, Daiwen Chen, Bing Yu, Jun He
Reactive oxide species are the middle products of normal metabolism, and play a crucial role in cell signaling transduction. On the contrary, accumulation of excess reactive oxide species results in oxidative stress that often brings multifarious impairment to cells, including decrease of ATP level in cells, elevation of cytosolic Ca(2+), DNA damage, dysfunction of biological function in lipid bilayer and so on. These effects will finally lead to all kinds of diseases. Tea polyphenols are widely considered as a kind of excellent antioxidant agents...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108572/a-cost-effective-assay-for-antioxidant-using-simple-cotton-thread-combining-paper-based-device-with-mobile-phone-detection
#14
Suphasinee Sateanchok, Sunanta Wangkarn, Chalermpong Saenjum, Kate Grudpan
A cost-effective assay for antioxidant using simple cotton thread combining paper based device with mobile phone detection has been investigated. Standard and sample solutions flow along a bunch of cotton thread treated with sodium hydroxide via microfluidic behaviors without external pumping. The analyte solution reacts with the reagents that have been immobilized on the paper strip fixed at the end of the cotton bunch. The developed platforms were used for the assays of total phenolic content and antioxidant capacity by employing Folin-Ciocalteu and 2, 2-diphenyl-1-picryhydrazyl (DPPH) respectively...
January 15, 2018: Talanta
https://www.readbyqxmd.com/read/29096961/cooking-and-co-ingested-polyphenols-reduce-in-vitro-methylmercury-bioaccessibility-from-fish-and-may-alter-exposure-in-humans
#15
Catherine Girard, Tania Charette, Maxime Leclerc, B Jesse Shapiro, Marc Amyot
Fish consumption is a major pathway for mercury exposure in humans. Current guidelines and risk assessments assume that 100% of methylmercury (MeHg) in fish is absorbed by the human body after ingestion. However, a growing body of literature suggests that this absorption rate may be overestimated. We used an in vitro digestion method to measure MeHg bioaccessibility in commercially-purchased fish, and investigated the effects of dietary practices on MeHg bioaccessibility. Cooking had the greatest effect, decreasing bioaccessibility on average to 12...
October 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29096085/proteomic-analysis-of-camellia-sinensis-l-reveals-a-synergistic-network-in-the-response-to-drought-stress-and-recovery
#16
Yu Wang, Kai Fan, Jing Wang, Zhao-Tang Ding, Hui Wang, Cai-Hong Bi, Yun-Wei Zhang, Hai-Wei Sun
Drought is a crucial limiting factor for tea yield and quality. To systematically characterize the molecular response of tea plants to drought stress and its capacity to recover, we used iTRAQ-based comparative proteomic approach to investigate the effects of drought on protein expression profiles in tea seedlings subjected to different drought treatments. A total of 3274 proteins were identified, of which 2169 and 2300 showed differential expressions during drought and recovery, respectively. Functional annotation showed that multiple biological processes were regulated, suggesting that tea plants probably employed multiple and synergistic resistance mechanisms in dealing with drought stress...
October 20, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29090295/neuroprotective-action-of-tea-polyphenols-on-oxidative-stress-induced-apoptosis-through-the-activation-of-the-trkb-creb-bdnf-pathway-and-keap1-nrf2-signaling-pathway-in-sh-sy5y-cells-and-mice-brain
#17
Guoyuan Qi, Yashi Mi, Yiwen Wang, Runnan Li, Shuxian Huang, Xingyu Li, Xuebo Liu
Many studies have shown that oxidative stress is a major cause of cellular injuries in a variety of human diseases including cognitive impairment. Tea polyphenols (TPs), natural plant flavonoids found in tea plant leaves, possess the bioactivity to affect the pathogenesis of several chronic diseases via antioxidant associated mechanisms. However, the possible antioxidant and neuroprotective properties of TPs in the brain of mice housed in constant darkness and in H2O2-stimulated SH-SY5Y cells are yet to be elucidated...
November 1, 2017: Food & Function
https://www.readbyqxmd.com/read/29081120/-role-of-green-tea-polyphenols-in-noise-induced-hearing-loss
#18
Y H Li, P S Jiang, Y W Su, Y M Liu
Objective: To investigate the role and mechanism of action of green tea polyphenols in noise-induced hearing loss. Methods: Male specific pathogen-free guinea pigs were randomly divided into normal control group with 9 guinea pigs, noise exposure group with 36 guinea pigs, and green tea polyphenol intervention group with 36 guinea pigs. Auditory brainstem response (ABR) threshold shift was examined before noise exposure and at 1, 3, 7, and 14 days of noise exposure. The surface preparation of cochlear basilar membrane was used for hair cell count and the morphology of hair cells was also observed...
August 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29080460/chlorogenic-acid-cga-a-pharmacological-review-and-call-for-further-research
#19
REVIEW
Muhammad Naveed, Veghar Hejazi, Muhammad Abbas, Asghar Ali Kamboh, Ghulam Jilany Khan, Muhammad Shumzaid, Fawwad Ahmad, Daryoush Babazadeh, Xia FangFang, Faezeh Modarresi-Ghazani, Li WenHua, Zhou XiaoHui
Phenolic acids have recently gained substantial attention due to their various practical, biological and pharmacological effects. Chlorogenic Acid (CGA, 3-CQA) is a most abundant isomer among caffeoylquinic acid isomers (3-, 4-, and 5-CQA), that currently known as 5-CQA as per guidelines of IUPAC. It is one of the most available acids among phenolic acid compounds which can be naturally found in green coffee extracts and tea. CGA is an important and biologically active dietary polyphenol, playing several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension, free radicals scavenger and a central nervous system (CNS) stimulator...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29073281/green-tea-polyphenols-alter-lipid-metabolism-in-the-livers-of-broiler-chickens-through-increased-phosphorylation-of-amp-activated-protein-kinase
#20
Jinbao Huang, Yibin Zhou, Bei Wan, Qiushi Wang, Xiaochun Wan
Our previous results showed that green tea polyphenols (GTPs) significantly altered the expression of lipid-metabolizing genes in the liver of chickens. However, the underlying mechanism was not elucidated. In this study, we further characterized how GTPs influence AMP-activated protein kinase (AMPK) in the regulation of hepatic fat metabolism. Thirty-six male chickens were fed GTPs at a daily dose of 0, 80 or 160 mg/kg of body weight for 4 weeks. The results demonstrated that oral administration of GTPs significantly reduced hepatic lipid content and abdominal fat mass, enhanced the phosphorylation levels of AMPKα and ACACA, and altered the mRNA levels and enzymatic activities of lipid-metabolizing enzymes in the liver...
2017: PloS One
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