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Tea polyphenols

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https://www.readbyqxmd.com/read/28432554/epigallocatechin-gallate-protects-beas-2b-cells-from-lipopolysaccharide-induced-apoptosis-through-upregulation-of-gastrin-releasing-peptide
#1
Peethambaran Divya, Bijesh Puthusseri, Denny Joseph Kollareth Manual, Mohammed Azharuddin Savanur
Gastrin-releasing peptide (GRP) plays a major role in the development and maintenance of lung epithelial cells by promoting cell division, whereas its suppression causes growth arrest and apoptosis. The present study shows that human bronchial epithelial BEAS-2B cells challenged with lipopolysaccharide (LPS), an endotoxin from gram-negative bacteria, downregulated GRP expression and induced apoptosis via upregulation of p53 and active caspase-3, signifying the importance of GRP in lung epithelial cell survival...
April 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28428087/searching-for-new-sources-of-innovative-products-for-the-food-industry-within-halophyte-aromatic-plants-in-vitro-antioxidant-activity-and-phenolic-and-mineral-contents-of-infusions-and-decoctions-of-crithmum-maritimum-l
#2
Catarina Guerreiro Pereira, Luísa Barreira, Nuno da Rosa Neng, José Manuel Florêncio Nogueira, Cátia Marques, Tamára F Santos, João Varela, Luísa Custódio
Aromatic halophyte plants are an outstanding source of bioactive compounds and natural products with potential use in the food industry. This work reports the in vitro antioxidant activity, toxicity, polyphenolic profile and mineral contents of infusions and decoctions from stems, leaves and flowers of Crithmum maritimum L., an aromatic and edible maritime halophyte (sea fennel). Aspalathus linearis (Burm.f.) Dahlg. (rooibos) herbal tea was used as a reference. Sea fennel's tisanes, particularly from leaves, were rich in phenolic compounds and five of them (p-hydroxybenzoic and ferulic acids, epicatechin, pyrocatechol and 4-hydroxybenzaldehyde) were here described in C...
April 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28428085/galloylation-of-polyphenols-alters-their-biological-activity
#3
REVIEW
Daniel Karas, Jitka Ulrichová, Kateřina Valentová
Polyphenols form one of the largest groups of natural compounds and possess a wide range of biological properties. These activities can be influenced by the galloyl moiety within their structures. A multitude of galloylated polyphenolic compounds occurs in nature, but galloylated phenols are also produced synthetically to influence their biological properties. This review provides a comprehensive summary of current knowledge about natural (galloylated catechins, theaflavins and proanthocyanidins, penta-O-galloyl-β-D-glucose, gallotannins, ellagitannins, ellagic acid and flavonols) and semisynthetic gallates with a focus on their biological activity and toxicity issues...
April 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28417981/reduced-prostate-cancer-risk-with-green-tea-and-epigallocatechin-3-gallate-intake-among-hong-kong-chinese-men
#4
P M Y Lee, C F Ng, Z M Liu, W M Ho, M K Lee, F Wang, H D Kan, Y H He, S S M Ng, S Y S Wong, L A Tse
BACKGROUND: In vitro and in vivo studies suggested that polyphenol epigallocatechin 3-gallate (EGCG) in tea may have anti-carcinogenic effect on prostate cells, but this protective effect has less been examined in epidemiology studies. We aimed to investigate the association between prostate cancer (PCA) risk and habitual green tea intake among Chinese men in Hong Kong; meanwhile, the relationship with EGCG was also explored. METHODS: We consecutively recruited 404 PCA cases and 395 controls from the same hospital who had complete data on habitual tea consumption, including green, oolong, black and pu'er tea...
April 18, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28416754/unique-synergistic-formulation-of-curcumin-epicatechin-gallate-and-resveratrol-tricurin-suppresses-hpv-e6-eliminates-hpv-cancer-cells-and-inhibits-tumor-progression
#5
Sumit Mukherjee, Priya Ranjan Debata, Rahman Hussaini, Kaushiki Chatterjee, Juliet N E Baidoo, Samay Sampat, Anita Szerszen, Joseph P Navarra, Jimmie Fata, Elena Severinova, Probal Banerjee, Mario R Castellanos
Curcumin (from curry) (C) is highly potent against cervical cancer cells (CCC), but poor bioavailability has limited its clinical use. Similar natural polyphenols resveratrol (from grapes) (R), and epicatechin gallate (from green tea) (E) also display activity against CCC. By treating CCC (HeLa) with C, E, or R, or combinations of these compounds, we computed combination indices and observed a strong synergism among C, E, and R at the unique molar ratio 4:1:12.5. This combination, named as TriCurin, rapidly down regulated HPV18 E6 and NF-kB expression while concomitantly inducing the tumor suppressor protein p53 in HeLa cells...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28407961/bionic-multi-tentacled-ionic-liquid-modified-silica-gel-for-adsorption-and-separation-of-polyphenols-from-green-tea-camellia-sinensis-leaves
#6
Wei Zhang, Xueting Feng, Yohannes Alula, Shun Yao
For the first time, a new kind of bionic multi-tentacled ionic liquid-modified silica gel was synthesized and used as selective adsorbent in the preparative separation of tea polyphenols (TP) from green tea leaves. It was found that silica particles with polyvinyl alcohol chains modified by N-methyl imidazole proline salt (PVA·Im(+)·Pro(-)@SiO2) had the excellent performance in selective adsorption as well as fine separation for target compounds. The new adsorbent exhibited high adsorption capacity and good reusability, meanwhile the antioxidant activity of TP could be improved through its efficient enrichment...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28401083/antioxidant-activities-of-functional-beverage-concentrates-containing-herbal-medicine-extracts
#7
Seon-Joo Park, Mi-Ok Kim, Jung Hoan Kim, Sehyun Jeong, Min Hee Kim, Su-Jin Yang, Jongsung Lee, Hae-Jeung Lee
This study investigated the antioxidant activity of functional beverage concentrates containing herbal medicine extracts (FBCH) using various antioxidant assays, such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity, and reducing power assay. The total polyphenolic content of FBCH (81.45 mg/100 g) was higher than Ssanghwa tea (SHT, 37.56 mg/100 g). The antioxidant activities of FBCH showed 52.92% DPPH and 55...
March 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28399674/optimization-and-validation-of-folin-ciocalteu-method-for-the-determination-of-total-polyphenol-content-of-pu-erh-tea
#8
Marilena Musci, Shicong Yao
Pu-erh tea is a post-fermented tea that has recently gained popularity worldwide, due to potential health benefits related to the antioxidant activity resulting from its high polyphenolic content. The Folin-Ciocalteu method is a simple, rapid, and inexpensive assay widely applied for the determination of total polyphenol content. Over the past years, it has been subjected to many modifications, often without any systematic optimization or validation. In our study, we sought to optimize the Folin-Ciocalteu method, evaluate quality parameters including linearity, precision and stability, and then apply the optimized model to determine the total polyphenol content of 57 Chinese teas, including green tea, aged and ripened Pu-erh tea...
April 12, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28395816/regeneration-of-tert-butylhydroquinone-by-tea-polyphenols
#9
Yafang Guo, Yahui Guo, Yunfei Xie, Yuliang Cheng, He Qian, Weirong Yao
To study the antioxidant capacity (AC) regeneration of tert-butylhydroquinone (TBHQ) by tea polyphenols (TPs), a separable system has been designed for its evaluation. The AC values of three natural food matrices (liquorice, oat, and ginger) and TBHQ regenerated by TPs were all higher than their controls, and similar to the initial values (p<0.05). The average regeneration efficiency (RE) value was 1.49 for these three natural food matrices, and 0.82 for TBHQ. Electron paramagnetic resonance spectroscopy analysis has revealed the synergistic effect of TBHQ and TPs, which arose from the regeneration of TBHQ by TPs...
May 2017: Food Research International
https://www.readbyqxmd.com/read/28393248/epigallocatechin-3-gallate-ameliorates-insulin-resistance-in-hepatocytes
#10
Shan-Bo Ma, Rui Zhang, Shan Miao, Bin Gao, Yang Lu, Sen Hui, Long Li, Xiao-Peng Shi, Ai-Dong Wen
Hyperglycemia is a typical pathogenic factor in a series of complications among patients with type II diabetes. Epigallocatechin-3-gallate (EGCG) is the major polyphenol extracted from green tea and is reported to be an antioxidant. The aim of the present study was to examine the effect of EGCG on insulin resistance in human HepG2 cells pretreated with high concentrations of glucose. The protein kinase B (AKT)/glycogen synthase kinase (GSK) pathways were analyzed using western blot analysis in HepG2 cells and primary mouse hepatocytes treated with high glucose and/or EGCG...
April 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28391664/effect-of-green-tea-added-tablets-on-volatile-sulfur-containing-compounds-in-the-oral-cavity
#11
Pier Francesco Porciani, Simone Grandini
OBJECTIVES: A controlled, clinical, double-blind, cross-over study was conducted to assess the efficacy of sugar-free tablets containing green tea extract on oral volatile sulfur-containing compounds (VSC) versus placebo tablets for 30 minutes. METHODS: To join the study, subjects had to have at least 24 teeth, no report of oral and systemic diseases, and no removable dentures. All eligible participants had to avoid professional oral hygiene and drugs for two weeks, to not be menstruating, to avoid brushing their teeth and tongue, to not smoke, to not consume alcohol, coffee or tea, nor onion, garlic, or licorice for six hours before the test...
December 2016: Journal of Clinical Dentistry
https://www.readbyqxmd.com/read/28391283/mothers-consumption-of-soy-drink-but-not-black-tea-increases-the-flavonoid-content-of-term-breast-milk-a-pilot-randomized-controlled-intervention-study
#12
Frank Jochum, Birgit Alteheld, Pamela Meinardus, Norbert Dahlinger, Antonia Nomayo, Peter Stehle
OBJECTIVE: We performed a pilot RCT to prove the hypothesis that a controlled ingestion of polyphenol-rich beverages (soy drink, decaffeinated black tea) in nutritive dosages by nursing women has an effect on the composition (flavonoid concentration, total antioxidant capacity) of breast milk. METHODS: Healthy nursing women were supplemented with either 250 mL of a soy drink (12 mg isoflavones; n = 18), 300 mL decaffeinated black tea (67 mg catechins; n = 18), or 300 mL water (n = 8, control) for 6 days...
April 8, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28389326/lipid-soluble-green-tea-extract-genotoxicity-and-subchronic-toxicity-studies
#13
Zheng Liu, Dongying Liu, Jianguo Cheng, Song Mei, Ying Fu, Weiqi Lai, Yin Wang, Yihong Xu, Trung D Vo, Barry S Lynch
To assess the potential safety of lipid soluble green tea extract, also referred to as lipid soluble tea polyphenols (LSTP), a series of genotoxicity tests were conducted, including an Ames, in vivo mouse micronucleus, and in vivo mouse sperm abnormality test. The toxicity of LSTP was evaluated in 90- and 30-day feeding studies. LSTP did not show mutagenic activity in the Ames test and no genotoxic potential in the in vivo assays at doses up to 10 g/kg body weight (bw). In the 90-day feeding study, LSTP was given in the diet at levels providing 0, 0...
April 4, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28385617/antioxidant-based-topical-formulations-influence-on-the-inflammatory-response-of-japanese-skin-a-clinical-study-using-non-invasive-techniques
#14
Tais A L Wagemaker, Patrícia M B G Maia Campos, Kenji Shimizu, Daiki Kyotani, Daisuke Yoshida
Cutaneous irritants exposure induces an excess of ROS in the skin and can ensue an inflammatory response. Topical antioxidant-based formulations can help to counteract ROS generation. This study evaluated the influence of antioxidant-based topical formulations on the inflammatory response of skin, using a combination of in vivo real-time non-invasive techniques. Nine test areas were defined on each volar forearm of the 25 Japanese volunteers. Measurements were performed before and after treatment with 15µL of a 5% sodium dodecyl sulfate solution and 15µL of the same based formulation or the vehicle with 1% of the antioxidants...
April 3, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28381812/a-simple-enzymatic-biotransformation-method-using-fresh-green-tea-leaves-efficiently-generates-theaflavin-containing-fermentation-water-that-has-potent-physiological-functions-in-mice-and-humans
#15
Masumi Takemoto, Hiroaki Takemoto, Haruka Kouno, Tomomi Soeda, Takamichi Moriya
The polyphenolic compound theaflavin, the main red pigment in black tea, possesses many beneficial properties, such as fat-reducing and glucose-lowering capabilities. To produce theaflavin-containing fermentation water on a large scale, we have developed a simple, inexpensive, and selective enzymatic biotransformation method to obtain sufficient levels from fresh green tea leaves. Subsequent administration of theaflavin-containing fermentation water to obese mice on a high-fat diet inhibited body weight gain, decreased casual blood glucose and fasting blood glucose levels, and lowered mesenteric and total fat composition...
April 1, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28379241/hypolipidemic-effect-of-youcha-in-hyperlipidemia-rats-induced-by-high-fat-diet
#16
Zhenjun Zhu, Zhongyi Lin, Hongrui Jiang, Yi Jiang, Mouming Zhao, Xiaoling Liu
Youcha is a novel tea drink from the northeast of Guangxi. This study aimed to investigate the hypolipidemic properties of Youcha in high-fat induced hyperlipidemic Sprague-Dawley (SD) rats. After designing the model, rats were randomly divided into six groups (n = 10): normal diet (NMD) group, high-fat diet (HFD) group, Xuezhikang (120 mg kg(-1) d(-1)) (HFD+P) group and Youcha (150, 750 or 1500 mg kg(-1) d(-1)) (HFD+L, HFD+M or HFD+H) groups. Youcha comprises tea polyphenols (1.51 g per 100 g), caffeine (34...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28379220/long-term-consumption-of-fermented-rooibos-herbal-tea-offers-neuroprotection-against-ischemic-brain-injury-in-rats
#17
Olusiji Akinrinmade, Sylvester Omoruyi, Daneel Dietrich, Okobi Ekpo
Stroke is the second leading cause of death worldwide, affecting about 240 people a day in South Africa and leaving survivors with residual disabilities. At the moment, there is no clinically approved neuroprotective product for stroke but the consumption of plant polyphenols has been suggested to offer some protection against stroke. In this study, we investigated the effects of long-term consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion (I/R)-induced brain injury in adult male Wistar rats...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28373046/structural-characterization-and-evaluation-of-the-antioxidant-activities-of-polysaccharides-extracted-from-qingzhuan-brick-tea
#18
Xinhe Yang, Mingjun Huang, Caiqin Qin, Bangyu Lv, Qingli Mao, Zhonghua Liu
The crude tea polysaccharides (CTPS) from Qingzhuan brick tea(QZBT) were extracted and fractionated to afford two fractions, namely TPS-1 and TPS-2. Analyses were conducted concerning the structural characterization and antioxidant activities of these samples. Component analysis revealed that the carbohydrate, uronic acid, protein and polyphenol contents of these samples differed significantly. Fourier transform infrared analysis showed that these samples showed similar characteristic absorption peaks for polysaccharides...
March 31, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28367927/beneficial-effects-of-lemon-balm-leaf-extract-on-in-vitro-glycation-of-proteins-arterial-stiffness-and-skin-elasticity-in-healthy-adults
#19
Shintaro Yui, Suzuka Fujiwara, Katsuhisa Harada, Mahoko Motoike-Hamura, Masashi Sakai, Satoshi Matsubara, Kouji Miyazaki
Glycation, a non-enzymatic glycosylation of proteins, induces tissue damage in association with various diseases and aging phenomena. Pentosidine, an advanced glycation end product, is involved in aging phenomena such as tissue stiffness. In this study, we aimed to find a potent anti-glycation food material and to verify its health benefits by clinical trial. From among 681 hot water plant extracts, lemon balm (Melissa officinalis; LB) leaf extract was selected and revealed to have more potent inhibitory activity for pentosidine formation than a representative anti-glycation agent, aminoguanidine...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28365685/-epigallocatechin-3-gallate-inhibits-arsenic-induced-inflammation-and-apoptosis-through-suppression-of-oxidative-stress-in-mice
#20
Nan-Hui Yu, Haiping Pei, Yong-Pan Huang, Yu-Fei Li
BACKGROUND/AIMS: Exposure to arsenic in individuals has been found to be associated with various health-related problems including skin lesions, cancer, and cardiovascular and immunological disorders. (-)-Epigallocatechin-3-gallate (EGCG), the main and active polyphenolic catechin present in green tea, has shown potent antioxidant, anti-apoptotic and anti-inflammatory activity in vivo and in vitro. Thus, the present study was conducted to investigate the protective effects of EGCG against arsenic-induced inflammation and immunotoxicity in mice...
April 3, 2017: Cellular Physiology and Biochemistry
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