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Tea polyphenols

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https://www.readbyqxmd.com/read/28534052/tea-polyphenol-t-arjuna-bark-as-sperm-antioxidant-extender-in-infertile-smokers
#1
R Parameswari, K A Rao, P Manigandan, A S Vickram, A Archana, T B Sridharan
BACKGROUND: Antioxidants protect spermatozoa against lipid peroxidation during freezing. OBJECTIVE: The study is designed to elucidate the suitable extender to preserve infertile semen of smokers against ROS damage using natural Tea polyphenol (T. arjuna bark extract). MATERIALS AND METHODS: Forty-two infertile subjects with smoking habit and 28 fertile subjects without smoking habit were considered for the study. Four semen extenders including our naturally derived antioxidant component were prepared and used to preserve semen sample from the study subjects for a period of one month...
March 2017: Cryo Letters
https://www.readbyqxmd.com/read/28531120/antidiabetic-effects-of-tea
#2
REVIEW
Qiu-Yue Fu, Qing-Sheng Li, Xiao-Ming Lin, Ru-Ying Qiao, Rui Yang, Xu-Min Li, Zhan-Bo Dong, Li-Ping Xiang, Xin-Qiang Zheng, Jian-Liang Lu, Cong-Bo Yuan, Jian-Hui Ye, Yue-Rong Liang
Diabetes mellitus (DM) is a chronic endocrine disease resulted from insulin secretory defect or insulin resistance and it is a leading cause of death around the world. The care of DM patients consumes a huge budget due to the high frequency of consultations and long hospitalizations, making DM a serious threat to both human health and global economies. Tea contains abundant polyphenols and caffeine which showed antidiabetic activity, so the development of antidiabetic medications from tea and its extracts is increasingly receiving attention...
May 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28530198/improved-bioavailability-and-pharmacokinetics-of-tea-polyphenols-by-encapsulation-into-gelatin-nanoparticles
#3
Karikalan Kulandaivelu, Abul Kalam Azad Mandal
The authors prepared surface modified (with polyelectrolyte layers), tea polyphenols (TPP) encapsulated, gelatin nanoparticles (TPP-GNP) and characterised them. The size of the spherical nanoparticles was ∼50 nm. Number of polyelectrolyte layers and incubation time influenced the encapsulation efficiency (EE); highest EE was noted in nanoparticles with six polyelectrolyte layers (TPP-GNP-6L) incubated for 4 h. TPP released from TPP-GNP-6L in simulated biological fluids indicated protection and controlled release of TPP due to encapsulation...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28520620/-epigallocatechin-3-gallate-ameliorates-memory-impairment-and-rescues-the-abnormal-synaptic-protein-levels-in-the-frontal-cortex-and-hippocampus-in-a-mouse-model-of-alzheimer-s-disease
#4
Yufang Guo, Yan Zhao, Ying Nan, Xiang Wang, Yulong Chen, Shuang Wang
(-)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenolic extract in green tea and it has attracted increasing attention for its multiple bioactive effects. However, the mechanisms by which EGCG exerts its neuroprotective actions in Alzheimer's disease (AD) are presently lacking. In the present study, a sporadic AD transgenic mouse model known as senescence-accelerated mouse prone 8 (SAMP8) was used to investigate whether oral administration of EGCG could improve recognition and memory function through reduction of amyloid β (Aβ) and tau hyperphosphorylation...
May 17, 2017: Neuroreport
https://www.readbyqxmd.com/read/28505110/green-tea-polyphenols-mimicking-the-effects-of-dietary-restriction-ameliorate-high-fat-diet-induced-kidney-injury-via-regulating-autophagy-flux
#5
Xiao Xie, Weijie Yi, Piwei Zhang, Nannan Wu, Qiaoqiao Yan, Hui Yang, Chong Tian, Siyun Xiang, Miying Du, Eskedar Getachew Assefa, Xuezhi Zuo, Chenjiang Ying
Epidemiological and experimental studies reveal that Western dietary patterns contribute to chronic kidney disease, whereas dietary restriction (DR) or dietary polyphenols such as green tea polyphenols (GTPs) can ameliorate the progression of kidney injury. This study aimed to investigate the renal protective effects of GTPs and explore the underlying mechanisms. Sixty Wistar rats were randomly divided into 6 groups: standard diet (STD), DR, high-fat diet (HFD), and three diets plus 200 mg/kg(bw)/day GTPs, respectively...
May 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28495234/oxidative-stress-induced-akt-downregulation-mediates-green-tea-toxicity-towards-prostate-cancer-cells
#6
Anna Maria Posadino, Hoa Thi Phu, Annalisa Cossu, Roberta Giordo, Marco Fois, Duong Thi Bich Thuan, Antonio Piga, Salvatore Sotgia, Angelo Zinellu, Ciriaco Carru, Gianfranco Pintus
Green tea consumption has been shown to possess cancer chemopreventive activity. Polyphenol E (PE) is a widely used standardized green tea extract formulation. This study was designed to investigate the impact of PE on prostate cancer cells (PC3), analyze the potential signals involved and elucidate whether anti- or pro-oxidant effects may be implicated. Treatment of PC3 cells with 30 and 100μg/ml PE significantly decreased cell viability and proliferation. At the tested concentrations, PE did not exert any antioxidant activity, eliciting instead a pro-oxidant effect at concentrations 30 and 100μg/ml, which was consistent with the observed PE cytotoxicity...
May 7, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28490136/antioxidative-capacity-and-binding-affinity-of-the-complex-of-green-tea-catechin-and-beta-lactoglobulin-glycated-by-the-maillard-reaction
#7
Marija Perusko, Ayah Al-Hanish, Jelena Mihailovic, Simeon Minic, Sara Trifunovic, Ivana Prodic, Tanja Cirkovic Velickovic
Major green tea catechin, epigallocatechin-3-gallate (EGCG), binds non-covalently to numerous dietary proteins, including beta-lactoglobulin of cow's milk. The effects of glycation of proteins via Maillard reaction on the binding capacity for polyphenols and the antiradical properties of the formed complexes have not been studied previously. Binding constant of BLG glycated by milk sugar lactose to EGCG was measured by the method of fluorophore quenching. Binding of EGCG was confirmed by CD and FTIR. The antioxidative properties of the complexes were examined by measuring ABTS radical scavenging capacity, superoxide anion scavenging capacity and total reducing power assay...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28487468/epigallocatechin-gallate-has-pleiotropic-effects-on-transmembrane-signaling-by-altering-the-embedding-of-transmembrane-domains
#8
Feng Ye, Chansik Yang, Jiyoon Kim, Christopher J MacNevin, Klaus M Hahn, Dongeun Park, Mark H Ginsberg, Chungho Kim
Epigallocatechin gallate (EGCG) is the principal bioactive ingredient in green tea and has been reported to have many health benefits. EGCG influences multiple signal transduction pathways related to human diseases, including redox, inflammation, cell cycle, and cell adhesion pathways. However, the molecular mechanisms of these varying effects are unclear, limiting further development and utilization of EGCG as a pharmaceutical compound. Here, we examined the effect of EGCG on two representative transmembrane signaling receptors, integrin αIIbβ3 and epidermal growth factor receptor (EGFR)...
May 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28486011/acteoside-and-acyl-migrated-acteoside-compounds-in-chinese-kudingcha-tea-inhibit-%C3%AE-amylase-in-vitro
#9
Yuqin Lu, Wenyu Zhou, Yue Feng, Yao Li, Ke Liu, Lizhong Liu, Dongxu Lin, Zhendan He, Xuli Wu
Acteoside, the predominant polyphenol of small-leaved kudingcha, the Chinese tea, has various biological activities. In this study, we examined the acyl migration of acteoside to isoacteoside with high-temperature treatment of acteoside. The inhibitory effects of acyl-migrated acteoside and acteoside on α-amylase were investigated, as were their binding interaction with α-amylase. The binding of acteoside and isoacteoside to α-amylase was investigated by using the fluorescence spectra assay, circular dichroism, and protein-ligand docking studies...
May 9, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28485162/epigallocatechin-gallate-inhibits-the-growth-of-salivary-adenoid-cystic-carcinoma-cells-via-the-egfr-erk-signal-transduction-pathway-and-the-mitochondria-apoptosis-pathway
#10
L X Weng, G H Wang, H Yao, M F Yu, J Lin
ACC is one of the most malignant tumors in salivary gland, and of poor prognosis. A critical role in ACC development and progression is played by EGFR family members including EGFR. EGCG, a low molecular weight polyphenol contained in green tea, has broad anticancer properties, but whether EGCG regulates activity of ACC is unknown. In the present study, the effects of EGCG were investigated in vitro with particular attention to the pathway of EGFR/Erk and mitochondria apoptosis in SACC-83 cell lines. The results of MTS assay and flow cytometry demonstrated that EGCG (20-80 μM) could inhibit proliferation and promote apoptosis of SACC-83 cells...
May 9, 2017: Neoplasma
https://www.readbyqxmd.com/read/28482335/nitric-oxide-mediates-brassinosteroid-induced-flavonoid-biosynthesis-in-camellia-sinensis-l
#11
Xin Li, Lan Zhang, Golam Jalal Ahammed, Zhi-Xin Li, Ji-Peng Wei, Chen Shen, Peng Yan, Li-Ping Zhang, Wen-Yan Han
Flavonoids are one of the key secondary metabolites determining the quality of tea. Although exogenous brassinosteroid (BR), a steroidal plant hormone, can stimulate polyphenol biosynthesis in tea plants (Camellia sinensis L.), the relevance of endogenous BR in flavonoid accumulation and the underlying mechanisms remain largely unknown. Here we show that BR enhances flavonoid concentration in tea leaves by inducing an increase in the endogenous concentration of nitric oxide (NO). Notably, exogenous BR increased levels of flavonoids as well as NO in a concentration dependent manner, while suppression of BR levels by an inhibitor of BR biosynthesis, brassinazole (BRz), decreased the concentrations of both flavonoids and NO in tea leaves...
April 12, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28479696/probable-benefits-of-green-tea-with-genetic-implications
#12
REVIEW
Kavita Singhal, Neerja Raj, Khushboo Gupta, Saurabh Singh
Tea is produced from the Camellia sinensis plant and can generally be divided into categories based on how they are processed. In general, green tea that is unfermented C. sinensis has been considered superior to black tea in health benefits. It contains a unique set of catechins that possess biological activity as antioxidant, anti-inflammatory and antiproliferative, which is potentially significant to the prevention and treatment of various forms of diseases. Oral cavity oxidative stress and inflammation, consequent cigarettes due to nicotine and acrolein, may be reduced in the presence of green tea polyphenols...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28468264/improvement-of-antioxidant-defences-and-mood-status-by-oral-gaba-tea-administration-in-a-mouse-model-of-post-stroke-depression
#13
Maria Daglia, Arianna Di Lorenzo, Seyed Fazel Nabavi, Antoni Sureda, Sedigheh Khanjani, Akbar Hajizadeh Moghaddam, Nady Braidy, Seyed Mohammad Nabavi
Green GABA (GGABA) and Oolong GABA (OGABA) teas are relatively new varieties of tea, whose chemical composition and functional properties are largely under-studied, despite their promising health capacities. Post stroke depression (PSD) is a complication of stroke with high clinical relevance, yielding increasing mortality and morbidity rates, and a lower response to common therapies and rehabilitation. METHODS: Two chemically characterized commercial samples of GGABA and OGABA were investigated for effects on mood following oral administration using a mouse model of PSD, through common validated tests including the Despair Swimming Test and Tail Suspension Test...
April 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28463548/effects-of-oolonghomobisflavan-a-on-oxidation-of-low-density-lipoprotein
#14
Enkhtsetseg Sukhbold, Shogo Sekimoto, Emiko Watanabe, Akane Yamazaki, Lifeng Yang, Mikako Takasugi, Koji Yamada, Ryota Hosomi, Kenji Fukunaga, Hirofumi Arai
Oxidation of low-density lipoprotein (LDL) by reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been suggested to be involved in the onset of atherosclerosis. Oolong tea contains unique polyphenols including oolonghomobisflavan A (OFA). In this study, the effects of OFA on LDL oxidation by ROS and RNS were investigated in vitro. OFA suppressed formation of cholesterol ester hydroperoxides in LDL oxidized by peroxyl radical and peroxynitrite, and formation of thiobarbituric acid reactive substances in LDL oxidized by Cu(2+)...
May 2, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28458007/probing-the-inhibitory-activity-of-epigallocatechin-gallate-on-toxic-aggregates-of-mutant-l84f-sod1-protein-through-geometry-based-sampling-and-steered-molecular-dynamics
#15
E Srinivasan, R Rajasekaran
Amyloid formation and protein aggregation are considered to be at the core of the disease pathology for the various neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS). Considerable experimental reports have suggested that epigallocatechin-gallate (EGCG), a natural polyphenol from the green tea inhibits the amyloid formation in multiple neurodegenerative disease. Mutations in SOD1 protein are considered to a key factor that contributes towards the rapid disease progression and the pathogenesis in both, the sporadic and familial form...
April 20, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28454102/an-inverse-association-between-tea-consumption-and-colorectal-cancer-risk
#16
Yuetong Chen, Yuan Wu, Mulong Du, Haiyan Chu, Lingjun Zhu, Na Tong, Zhengdong Zhang, Meilin Wang, Dongying Gu, Jinfei Chen
It is well known that the tea extracts, mainly polyphenols as chemo-preventive elements, could act as cancer progression blockers. Although the association between tea consumption and colorectal cancer risk has been widely investigated, the results still remain inconsistent. We conducted a dose-response meta-analysis to evaluate their relationships by enrolling qualified 29 literatures. The summary odds ratio (OR) of colorectal cancer for the highest vs. lowest tea consumption was 0.93 with 0.87-1.00 of 95% confidence intervals (CIs) among all studies with modest heterogeneity (P = 0...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28432554/epigallocatechin-gallate-protects-beas-2b-cells-from-lipopolysaccharide-induced-apoptosis-through-upregulation-of-gastrin-releasing-peptide
#17
Peethambaran Divya, Bijesh Puthusseri, Denny Joseph Kollareth Manual, Mohammed Azharuddin Savanur
Gastrin-releasing peptide (GRP) plays a major role in the development and maintenance of lung epithelial cells by promoting cell division, whereas its suppression causes growth arrest and apoptosis. The present study shows that human bronchial epithelial BEAS-2B cells challenged with lipopolysaccharide (LPS), an endotoxin from gram-negative bacteria, downregulated GRP expression and induced apoptosis via upregulation of p53 and active caspase-3, signifying the importance of GRP in lung epithelial cell survival...
April 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28428087/searching-for-new-sources-of-innovative-products-for-the-food-industry-within-halophyte-aromatic-plants-in-vitro-antioxidant-activity-and-phenolic-and-mineral-contents-of-infusions-and-decoctions-of-crithmum-maritimum-l
#18
Catarina Guerreiro Pereira, Luísa Barreira, Nuno da Rosa Neng, José Manuel Florêncio Nogueira, Cátia Marques, Tamára F Santos, João Varela, Luísa Custódio
Aromatic halophyte plants are an outstanding source of bioactive compounds and natural products with potential use in the food industry. This work reports the in vitro antioxidant activity, toxicity, polyphenolic profile and mineral contents of infusions and decoctions from stems, leaves and flowers of Crithmum maritimum L., an aromatic and edible maritime halophyte (sea fennel). Aspalathus linearis (Burm.f.) Dahlg. (rooibos) herbal tea was used as a reference. Sea fennel's tisanes, particularly from leaves, were rich in phenolic compounds and five of them (p-hydroxybenzoic and ferulic acids, epicatechin, pyrocatechol and 4-hydroxybenzaldehyde) were here described in C...
April 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28428085/galloylation-of-polyphenols-alters-their-biological-activity
#19
REVIEW
Daniel Karas, Jitka Ulrichová, Kateřina Valentová
Polyphenols form one of the largest groups of natural compounds and possess a wide range of biological properties. These activities can be influenced by the galloyl moiety within their structures. A multitude of galloylated polyphenolic compounds occurs in nature, but galloylated phenols are also produced synthetically to influence their biological properties. This review provides a comprehensive summary of current knowledge about natural (galloylated catechins, theaflavins and proanthocyanidins, penta-O-galloyl-β-d-glucose, gallotannins, ellagitannins, ellagic acid and flavonols) and semisynthetic gallates with a focus on their biological activity and toxicity issues...
April 18, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28417981/reduced-prostate-cancer-risk-with-green-tea-and-epigallocatechin-3-gallate-intake-among-hong-kong-chinese-men
#20
P M Y Lee, C F Ng, Z M Liu, W M Ho, M K Lee, F Wang, H D Kan, Y H He, S S M Ng, S Y S Wong, L A Tse
BACKGROUND: In vitro and in vivo studies suggested that polyphenol epigallocatechin 3-gallate (EGCG) in tea may have anti-carcinogenic effect on prostate cells, but this protective effect has less been examined in epidemiology studies. We aimed to investigate the association between prostate cancer (PCA) risk and habitual green tea intake among Chinese men in Hong Kong; meanwhile, the relationship with EGCG was also explored. METHODS: We consecutively recruited 404 PCA cases and 395 controls from the same hospital who had complete data on habitual tea consumption, including green, oolong, black and pu'er tea...
April 18, 2017: Prostate Cancer and Prostatic Diseases
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