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Tea polyphenols

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https://www.readbyqxmd.com/read/28110479/epigallocatechin-3-o-gallate-modulates-global-microrna-expression-in-interleukin-1%C3%AE-stimulated-human-osteoarthritis-chondrocytes-potential-role-of-egcg-on-negative-co-regulation-of-microrna-140-3p-and-adamts5
#1
Zafar Rasheed, Naila Rasheed, Osama Al-Shaya
PURPOSE: MicroRNAs (miRNAs) are short, non-coding RNAs involved in almost all cellular processes. Epigallocatechin-3-O-gallate (EGCG) is a green tea polyphenol and is known to exert anti-arthritic effects by inhibiting genes associated with osteoarthritis (OA). This study was undertaken to investigate the global effect of EGCG on interleukin-1β (IL-1β)-induced expression of miRNAs in human chondrocytes. METHODS: Human chondrocytes were derived from OA cartilage and then treated with EGCG and IL-1β...
January 21, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28107697/egcg-a-tea-polyphenol-as-a-potential-mitigator-of-hematopoietic-radiation-injury-in-mice
#2
Mrinalini Tiwari, Bhakti Dixit, Suhel Parvez, Paban K Agrawala
Agents capable of providing protection, mitigation or therapy against radiation injuries have long been of interest of radiation biologists owing to the ever expanding application of radiation in our day to day life despite the well reported ill effects of exposure. The current study investigates radiomitigating potential of EGCG (epigallocatechin gallate), a tea polyphenol with known DNMT inhibitory property, in C57 Bl/6 mice model. Treatment with 0.1833mg/kg body weight EGCG, 1.5h post-irradiation to lethally whole body irradiated mice rendered 45% survival for 30days and also helped restoring the body weight of the animals...
January 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28102295/bioactive-compounds-and-antioxidant-activity-of-wolfberry-infusion
#3
Yujing Sun, Japaer Rukeya, Wenyang Tao, Peilong Sun, Xingqian Ye
An infusion of the wolfberry (Lycium barbarum L.) is a traditional Asian herbal tea. This is the most commonly consumed form of dried wolfberry worldwide, yet little scientific information on wolfberry infusions is available. We investigated the effects of making infusions with hot water on the color, the content of bioactive compounds (polysaccharides, polyphenols, flavonoids and carotenoids) and the antioxidant ability of wolfberry infusions. The contents of bioactive compounds and the antioxidant activity of a wolfberry infusion increased with increased infusion temperature and time...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28099027/inactivation-of-soybean-trypsin-inhibitor-by-epigallocatechin-gallate-stopped-flow-fluorescence-thermodynamics-and-docking-studies
#4
Chun Liu, Fenfen Cheng, Xiaoquan Yang
Tea is one of the most widely daily consumed beverages all over the world, and it is usually consumed with milk and/or soy milk. However, very few researches have studied the interactions between tea polyphenols (TPs) and soy milk proteins as compared with milk proteins. Here, we reported that epigallocatechin gallate (EGCG), a major component of TPs, can effectively inhibit the inhibitory activity of Kunitz trypsin inhibitor (KTI, a major antinutrient in soy milk). The mechanism of inactivation of KTI by EGCG was investigated by stopped-flow/fluorescence, thermodynamics, and docking studies...
January 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28097041/effect-of-catechins-green-tea-extract-and-methylxanthines-in-combination-with-gentamicin-against-staphylococcus-aureus-and-pseudomonas-aeruginosa-combination-therapy-against-resistant-bacteria
#5
Bibi Sedigheh Fazly Bazzaz, Sahar Sarabandi, Bahman Khameneh, Hossein Hosseinzadeh
OBJECTIVES: Bacterial resistant infections have become a global health challenge and threaten the society's health. Thus, an urgent need exists to find ways to combat resistant pathogens. One promising approach to overcoming bacterial resistance is the use of herbal products. Green tea catechins, the major green tea polyphenols, show antimicrobial activity against resistant pathogens. The present study aimed to investigate the effect of catechins, green tea extract, and methylxanthines in combination with gentamicin against standard and clinical isolates of Staphylococcus aureus (S...
December 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28091970/comparison-of-two-adsorbent-based-de-bittering-procedures-for-neem-azadirachta-indica-a-juss-tea-effect-on-polyphenols-anti-oxidant-capacity-color-and-volatile-profile
#6
Abhinandya Datta, Ingolf U Grün, Misha T Kwasniewski, Lakdas N Fernando
Bitterness reduction, especially of foods and beverages containing phytonutrients, is one of the biggest challenges in the food industry because bitterness has a deleterious effect on the taste profile of foods and beverages. Neem (Azadirachta indica A. Juss) is a medicinal tree, indigenous to the Indian-subcontinent, whose medicinal properties have led to it being heralded as the tree which is the "panacea for all diseases". However, neem leaf is extremely bitter, in large part due to its limonoid content, making it unpalatable...
January 14, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28090275/induction-of-epigenetic-alteration-by-cpuk02-an-ent-kaurenoid-derivative-of-stevioside
#7
Pooneh Mokarram, Zeinab Mohammadi, Saeid Khazayel, Zhang Dayong
BACKGROUND: Dietary polyphenols, such as those found in green tea and red wine, are linked to antitumor activity. They are known to influence many signaling pathways epigenetically within the human body. In this regard, CPUK02 (15-Oxosteviol benzyl ester) is a new ent-kaurenoid derivative of stevioside and exhibits strong anti-cancer activity in vitro and in vivo. Nowadays, the role of epigenetics in cancer has been the subject of intensive study and DNA methylation targeting represents a relevant strategy for cancer treatment...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28079202/oligomer-formation-of-a-tea-polyphenol-egcg-on-its-sensing-molecule-67-kda-laminin-receptor
#8
Yuhui Huang, Mami Sumida, Motofumi Kumazoe, Kaori Sugihara, Yumi Suemasu, Shuhei Yamada, Shuya Yamashita, Jyunichi Miyakawa, Takashi Takahashi, Hiroshi Tanaka, Yoshinori Fujimura, Hirofumi Tachibana
Green tea polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) has been attributed to the activation of its cell surface sensing receptor 67 kDa laminin receptor (67LR). However, the action of EGCG to activate 67LR remains unknown. Here we show that EGCG undergoes oligomer formation on its surface receptor 67LR.
January 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28071022/research-on-the-effect-of-culture-time-on-the-kombucha-tea-beverage-s-antiradical-capacity-and-sensory-value
#9
Anna Gramza-Michałowska, Bartosz Kulczyński, Yuan Xindi, Małgorzata Gumienna
BACKGROUND: Recent consumption trends shows high consumer acceptability and growing medicinal interest in the biological value of kombucha tea. This tea is a sweetened tea leaf brew fermented with a layer containing mainly acetic acid bacteria, yeast and lactic acid bacteria. The main antioxidants in tea leaves are polyphenols, the consumption of which is proven to be beneficial for human health, e.g. protecting from reactive oxygen species (ROS). The aim of the present research was to evaluate antiradical activity, total polyphenol content (TPC) and sensory value of kombucha tea brews...
October 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28058738/epigallocatechin-3-gallate-egcg-and-green-tea-polyphenols-do-not-improve-stallion-semen-parameters-during-cooling-at-4%C3%A2-c
#10
D Bucci, M Spinaci, B Mislei, B Gadani, G Rizzato, C C Love, C Tamanini, G Galeati, G Mari
Stallion semen storage for artificial insemination is mainly based on liquid cooled storage. In many stallions this technique maintains sperm quality for an extended period of time (24-72 hr) at 7°C. While this technique is commonly used in the horse industry, there can be a decline in fertility in some stallions, due to an inability of their sperm to tolerate the cool storage process. The aim of the present work was to evaluate the effect of two natural antioxidants (epigallocatechin-3-gallate (EGCG) at 20, 60 and 120 μm and green tea polyphenols, and p at ...
January 6, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28053887/components-in-aqueous-hibiscus-rosa-sinensis-flower-extract-inhibit-in%C3%A2-vitro-melanoma-cell-growth
#11
Karina H Goldberg, Ariel C Yin, Archana Mupparapu, Edward P Retzbach, Gary S Goldberg, Catherine F Yang
Skin cancer is extremely common, and melanoma causes about 80% of skin cancer deaths. In fact, melanoma kills over 50 thousand people around the world each year, and these numbers are rising. Clearly, standard treatments are not effectively treating melanoma, and alternative therapies are needed to address this problem. Hibiscus tea has been noted to have medicinal properties, including anticancer effects. Extracts from Hibiscus have been shown to inhibit the growth of a variety of cancer cells. In particular, recent studies found that polyphenols extracted from Hibiscus sabdariffa by organic solvents can inhibit melanoma cell growth...
January 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28049293/small-angle-x-ray-scattering-study-of-protein-complexes-with-tea-polyphenols
#12
Ce Shi, Haifeng Tang, Jie Xiao, Fengchao Cui, Kecheng Yang, Ji Li, Qin Zhao, Qingrong Huang, Yunqi Li
Exploration of the structure of protein complexes, especially the change in conformation and aggregation behavior of proteins upon ligand binding, is crucial to clarify their bioactivities at the molecular level. We applied solution small-angle X-ray scattering (SAXS) to study the complex structure of bovine serum albumin (BSA) and trypsin binding with tea polyphenols, that is, catechin and epigallocatechin gallate (EGCG). We found that tea polyphenols can steadily promote the aggregation of proteins and protein complexes through their bridging effect...
January 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28049262/black-tea-consumption-improves-postprandial-glycemic-control-in-normal-and-pre-diabetic-subjects-a-randomized-double-blind-placebo-controlled-crossover-study
#13
Arisa Butacnum, Rewadee Chongsuwat, Akkarach Bumrungpert
BACKGROUND AND OBJECTIVES: Postprandial glycemic control is important for prevention of diabetes. Black tea consumption may improve postprandial glycemic control. The major bioactive compounds are polyphenols, black tea polymerized polyphenol (BTPP).This study examined the effect of black tea consumption on postprandial blood glucose and insulin response following sucrose loading in normal and pre-diabetes subjects. METHODS AND STUDY DESIGN: This study was a randomized, double-blind, placebo-controlled crossover study...
January 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28040581/egcg-inhibited-bladder-cancer-sw780-cell-proliferation-and-migration-both-in-vitro-and-in-vivo-via-down-regulation-of-nf-%C3%AE%C2%BAb-and-mmp-9
#14
Ke-Wang Luo, Wei Chen, Wing-Yin Lung, Xia-Yun Wei, Bao-Hui Cheng, Zhi-Ming Cai, Wei-Ren Huang
Epigallocatechin-3-gallate (EGCG), the bioactive polyphenol in green tea, has been demonstrated to have various biological activities. Our study aims to investigate the antiproliferation and antimigration effects of EGCG against bladder cancer SW780 cells both in vitro and in vivo. Our results showed that treatment of EGCG resulted in significant inhibition of cell proliferation by induction of apoptosis, without obvious toxicity to normal bladder epithelium SV-HUC-1 cells. EGCG also inhibited SW780 cell migration and invasion at 25-100 μM...
December 20, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28040061/preservation-effect-of-meat-product-by-natural-antioxidant-tea-polyphenol
#15
W-D Wang, Y-E Sun
1% of tea polyphenol, chitosan solution and potassium sorbate were used as film-forming materials to coat chilled mutton. Total coliforms, TVB-N value and pH value were determined and used as the mutton fresh-keeping indexes. The results showed that after 12th day at the end of the storage, mutton coated with tea polyphenol had best effects comparing chitosan solution and potassium sorbate. pH value of mutton coated by tea polyphenol was 6.0, TVB-N and the total coliforms were both significantly lower than the meat coated by chitosan solution and potassium sorbate...
November 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28038426/oxidized-epigallocatechin-gallate-inhibited-lysozyme-fibrillation-more-strongly-than-the-native-form
#16
Ting-Ting An, Shuang Feng, Cheng-Ming Zeng
Epigallocatechin gallate (EGCG), the most abundant flavanoid in green tea, is currently being evaluated in the clinic due to its benefits in the treatment of amyloid disorders. Its anti-amyloidogenic effect has been attributed to direct interaction of the intact molecule with misfolded polypeptides. In addition, antioxidant activity is also involved in the anti-amyloidogenic role. The detailed molecular mechanism is still unclear and requires further investigation. In the present study, the kinetics of EGCG oxidation and the anti-amyloidogenic effect of the resultant oxidation substances have been examined...
December 21, 2016: Redox Biology
https://www.readbyqxmd.com/read/28036089/chemical-composition-and-antioxidant-activity-of-euterpe-oleracea-roots-and-leaflets
#17
Christel Brunschwig, Louis-Jérôme Leba, Mona Saout, Karine Martial, Didier Bereau, Jean-Charles Robinson
Euterpe oleracea (açaí) is a palm tree well known for the high antioxidant activity of its berries used as dietary supplements. Little is known about the biological activity and the composition of its vegetative organs. The objective of this study was to investigate the antioxidant activity of root and leaflet extracts of Euterpe oleracea (E. oleracea) and characterize their phytochemicals. E. oleracea roots and leaflets extracts were screened in different chemical antioxidant assays (DPPH-2,2-diphenyl-1-picrylhydrazyl, FRAP-ferric feducing antioxidant power, and ORAC-oxygen radical absorbance capacity), in a DNA nicking assay and in a cellular antioxidant activity assay...
December 29, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28036057/green-tea-and-other-tea-polyphenols-effects-on-sebum-production-and-acne-vulgaris
#18
REVIEW
Suzana Saric, Manisha Notay, Raja K Sivamani
Polyphenols are antioxidant molecules found in many foods including nuts, fruits, vegetables, chocolate, wine, and tea. Polyphenols have antimicrobial, anti-inflammatory, and antineoplastic properties. Recent studies suggest that tea polyphenols may be used for reducing sebum production in the skin and for treatment of acne vulgaris. This review examines the evidence for use of topically and orally ingested tea polyphenols against sebum production and for acne treatment and prevention. The PubMed database was searched for studies on tea polyphenols, sebum secretion, and acne vulgaris...
December 29, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28035959/mobilization-of-nuclear-copper-by-green-tea-polyphenol-epicatechin-3-gallate-and-subsequent-prooxidant-breakage-of-cellular-dna-implications-for-cancer-chemotherapy
#19
Mohd Farhan, Mohammad Oves, Sandesh Chibber, Sheikh Mumtaz Hadi, Aamir Ahmad
Epidemiological as well as experimental evidence exists in support of chemopreventive and anticancer properties of green tea and its constituents. The gallocatechin, epicatechin-3-gallate is a major polyphenol present in green tea, shown responsible for these effects. Plant-derived polyphenolic compounds are established natural antioxidants which are capable of catalyzing oxidative DNA degradation of cellular DNA, alone as well as in the presence of transition metal ions, such as copper. Here we present evidence to support that, similar to various other polyphenoic compounds, epicatechin-3-gallate also causes oxidative degradation of cellular DNA...
December 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28031235/htp-nutraceutical-screening-for-histone-deacetylase-inhibitors-and-effects-of-hdacis-on-tumor-suppressing-mirnas-by-trichostatin-a-and-grapeseed-vitis-vinifera-in-hela-cells
#20
Elizabeth A Mazzio, Karam F A Soliman
BACKGROUND/AIM: Aggressive tumor malignancies are a consequence of delayed diagnosis, epigenetic/phenotype changes and chemo-radiation resistance. Histone deacetylases (HDACs) are a major epigenetic regulator of transcriptional repression, which are highly overexpressed in advanced malignancy. While original chemotherapy drugs were modeled after phytochemicals elucidated by botanical screenings, HDAC inhibitors (HDACi) such as apicidin, trichostatin A (TSA) and butyrate were discovered as products of fungus and microbes, in particular, gut microbiota...
2, 2017: Cancer Genomics & Proteomics
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