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lobectomy in lung cancer

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https://www.readbyqxmd.com/read/28628562/robotic-versus-video-assisted-lobectomy-segmentectomy-for-lung-cancer-a-meta-analysis
#1
Hengrui Liang, Wenhua Liang, Lei Zhao, Difei Chen, Jianrong Zhang, Yiyin Zhang, Shiyan Tang, Jianxing He
: Objective: To compare the safety/efficacy of the robotic-assisted lobectomy/segmentectomy (RAL/S) with the video-assisted lobectomy/segmentectomy (VAL/S) for radical lung cancer resection. BACKGROUND: It remains uncertain whether the newly developed RAL/S is comparable with the VAL/S. METHODS: A comprehensive search of online databases was performed. Perioperative outcomes were synthesized. Cumulative meta-analysis was performed to evaluate the temporal trend of pooled outcomes...
June 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28628492/complete-remission-of-intrathecal-metastases-with-lorlatinib-therapy-in-a-heavily-pretreated-alk-positive-lung-cancer-patient
#2
Maximilian J Hochmair, Sophia Schwab, Helmut Prosch
Patients with lung cancer who show EML4-ALK translocation are routinely treated with ALK tyrosine kinase inhibitors, although in the majority of cases, these patients develop resistance over time. The central nervous system is a common of site of recurrence in this population, which calls for next-generation drugs that can penetrate into the brain and achieve clinically meaningful central nervous system activity. Here, I report the case of a female patient diagnosed with adenocarcinoma of the lung in 2005, at the age of 46 years, who underwent lobectomy and then experienced a series of progression episodes 6 years later...
June 16, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28621182/-non-intubated-uniportal-video-assisted-thoracic-surgery-vats-lobectomy-as-a-new-procedure-in-our-department
#3
József Furák, Zsolt Szabó, Theodor Horváth, Tibor Géczi, Balázs Pécsy, Tibor Németh, Aurél Ottlakán, Zsolt Molnár, György Lázár
AIM: Due to the emerging experience in VATS (video assisted thoracic surgery) lobectomies, in some centers the so called "non-intubated" VATS lobectomies (NITS - non-intubated thoracic surgery) gained increased authority, during which endotracheal intubation and muscle relaxation of the patient is not carried out, thus surgery is being performed with the patient breathing spontaneously. The recent study deals with our initial experience gained during uniportal NITS VATS lobectomies. PATIENTS AND METHOD: Between 24...
June 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28619764/medicoeconomic-analysis-of-lobectomy-using-thoracoscopy-versus-thoracotomy-for-lung-cancer-a-study-protocol-for-a-multicentre-randomised-controlled-trial-lungsco01
#4
Pierre-Benoit Pagès, Halim Abou Hanna, Anne-Claire Bertaux, Ludwig Serge Serge Aho, Pierre Magdaleinat, Jean-Marc Baste, Marc Filaire, Richard de Latour, Jalal Assouad, François Tronc, Christophe Jayle, Jérome Mouroux, Pascal-Alexandre Thomas, Pierre-Emmanuel Falcoz, Charles-Henri Marty-Ané, Alain Bernard
INTRODUCTION: In the last decade, video-assisted thoracoscopic surgery (VATS) lobectomy for non-small cell lung cancer (NSCLC) has had a major effect on thoracic surgery. Retrospective series have reported benefits of VATS when compared with open thoracotomy in terms of postoperative pain, postoperative complications and length of hospital stay. However, no large randomised control trial has been conducted to assess the reality of the potential benefits of VATS lobectomy or its medicoeconomic impact...
June 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28616702/the-indication-of-completion-lobectomy-for-lung-adenocarcinoma-%C3%A2-3%C3%A2-cm-after-wedge-resection-during-surgical-operation
#5
Yiyang Wang, Rui Wang, Difan Zheng, Baohui Han, Jie Zhang, Heng Zhao, Jizhuang Luo, Jiajie Zheng, Tianxiang Chen, Qingyuan Huang, Yihua Sun, Haiquan Chen
PURPOSE: This retrospective study was designed to find out the potential indications of completion lobectomy (CL) during wedge resection (WR) operation among patients with lung adenocarcinoma (ADC) ≤3 cm, by the use of Shanghai Chest Hospital Lung Cancer Database. PATIENTS AND METHODS: There were totally 1938 patients in this study, including 746 WRs and 1192 CLs. The propensity score matching (PSM) was performed to minimize the effect of confounders. Univariable and multivariable cox regressions were analyzed to discover the independent risk factors of recurrence-free survival (RFS) and overall survival (OS)...
June 14, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28616292/uniportal-video-assisted-thoracoscopic-surgery-left-upper-lobectomy-and-systematic-lymph-node-dissection-with-fused-fissure
#6
Ying Chen, Jun-Tao Lin, Song Dong, Xue-Ning Yang, Yi-Long Wu, Wen-Zhao Zhong
As surgical proficiency and the development of medical techniques have improved, uniportal video-assisted thoracoscopic surgery (VATS) has emerged as a minimally invasive alternative in the surgical management of lung cancer. The spectrum of uniportal VATS indications is now almost equal to that of conventional VATS. Recent decades have witnessed the emergence of numerous uniportal VATS techniques. A significant proportion of these have to be converted into a multiport approach and even open thoracotomy due to the difficulty of managing the upper lobe vein and bronchus, particularly for the technically challenging left upper lobectomy...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28610591/propensity-score-matching-analysis-of-postoperative-radiotherapy-for-stage-iiia-n2-non-small-cell-lung-cancer-using-the-surveillance-epidemiology-and-end-results-database
#7
Shenhai Wei, Mian Xie, Jintao Tian, Xiaoping Song, Bingqun Wu, Limin Liu
BACKGROUND: To investigate the effects of postoperative radiotherapy (PORT) on the survival of patients with resected stage IIIA-N2 non-small cell lung cancer (NSCLC). METHODS: A total of 3,334 patients with resected stage IIIA-N2 NSCLC in 2004 to 2013 were identified in the Surveillance, Epidemiology, and End Results database and stratified according to use of PORT. Propensity score-matching (PSM) methods were used to balance the baseline characteristics of patients who did (n = 744) or did not (n = 744) undergo PORT...
June 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28603719/prospective-study-of-quality-of-life-after-lung-cancer-resection
#8
Kathleen G Hopkins, Peter F Ferson, Manisha R Shende, Neil A Christie, Matthew J Schuchert, Arjun Pennathur
BACKGROUND: Surgical resection with curative-intent remains the gold standard for clinically operable early-stage non-small cell lung cancer (NSCLC). This goal can be accomplished using a minimally invasive option, e.g., video assisted thoracic surgery (VATS) or standard thoracotomy. Surgical techniques continue to evolve and few studies have compared the QOL of patients managed with these procedures using current approaches. The primary goal of this study was to investigate differences between patients managed surgically via VATS compared to thoracotomy with respect to ratings of chronic pain, anxiety/depression and quality of life (QOL)...
May 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28603368/comparison-between-stair-climbing-test-and-six-minute-walk-test-after-lung-resection-using-video-assisted-thoracoscopic-surgery-lobectomy
#9
Yohei Kubori, Ryosuke Matsuki, Akira Hotta, Tomoyuki Morisawa, Akira Tamaki
[Purpose] Currently, the six-minute walk distance (6MWD) is used to evaluate exercise capacity in people following lung resection for non-small cell lung cancer. However, it is unclear whether the 6MWD can detect changes in cardiorespiratory fitness induced by exercise training or lung resection. Conversely, the stair-climbing test is used frequently for the preoperative evaluation of lung resection candidates. It is considered a sensitive method for detecting changes associated with training, but is not used to evaluate exercise capacity after lung resection...
May 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28597091/prognosis-after-sublobar-resection-of-small-sized-non-small-cell-lung-cancer-with-visceral-pleural-or-lymphovascular-invasion
#10
Youngkyu Moon, Kyo Young Lee, Jae Kil Park
BACKGROUND: Although standard surgical treatment of stage I non-small cell lung cancer (NSCLC) is lobectomy, sublobar resection may be elected for small-sized (≤2 cm) peripheral tumors. Our aim was examine the need for completion lobectomy in the event of confirmed pleural or lymphovascular invasion after sublobar resection of NSCLC. METHODS: A total of 271 consecutive patients undergoing curative resection of stage I NSCLC ≤2 cm were reviewed retrospectively, analyzing clinicopathologic findings and survival times of those with invasion-positive (visceral pleural or lymphovascular invasion) or invasion-negative (neither visceral pleural nor lymphovascular invasion) tumors by surgical approach (sublobar resection vs lobectomy)...
June 8, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28596492/detection-of-tumor-derived-dna-dispersed-in-the-airway-improves-the-diagnostic-accuracy-of-bronchoscopy-for-lung-cancer
#11
Taichiro Goto, Yosuke Hirotsu, Takahiro Nakagomi, Daichi Shikata, Yujiro Yokoyama, Kenji Amemiya, Toshiharu Tsutsui, Yumiko Kakizaki, Toshio Oyama, Hitoshi Mochizuki, Yoshihiro Miyashita, Masao Omata
The diagnostic accuracy of bronchoscopy for detecting lung cancer, especially peripheral lung cancer with lesions outside the endoscopically visible range, remains unsatisfactory. The aim of this study was to perform next-generation sequencing on bronchoscopic specimens to determine whether this improves the accuracy of bronchoscopy for diagnosing lung cancer and to identify factors influencing sensitivity. The bronchoscopic sensitivity for diagnosing lung cancer was initially evaluated in 191 patients who underwent lobectomy after bronchoscopy at our hospital...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28595234/-lung-cancer-with-multiple-cavitation-and-ground-glass-opacity-report-of-a-case
#12
Ken Takeuchi, Nobuyasu Hayakawa, Motofumi Oouchi
A 81-year-old man was referred to our hospital because of cough and fever. Chest computed tomography(CT) showed multiple cavitation and ground glass opacity in the right lower lobe. Antibiotic treatment was effective in the improvement of the infiltrative shadow and the inflammatory reaction. After 1 year, bronchoscopy was performed because the shadow remained on the following chest CT, and the adenocarcinoma of the lung was found. A lower lobectomy of the right lung was performed.
June 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28577955/surgery-versus-chemotherapy-and-radiotherapy-for-early-and-locally-advanced-small-cell-lung-cancer-a-propensity-matched-analysis-of-survival
#13
E Wakeam, S A Acuna, N B Leighl, M E Giuliani, S R G Finlayson, T K Varghese, G E Darling
BACKGROUND: The role of surgery in small cell lung cancer (SCLC) is controversial. Survival outcomes for resection of stage I-IIIA SCLC compared to chemotherapy-based non-surgical treatment (NST) were examined using propensity matching. METHODS: 29,994 clinical stage I-IIIA SCLC patients, including 2,619 undergoing surgery, were identified in the National Cancer Database. Stage-specific propensity scores for receipt of surgery were created. Resected patients were matched 1:1 to those undergoing NST...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28577940/trends-practice-patterns-and-underuse-of-surgery-in-the-treatment-of-early-stage-small-cell-lung-cancer
#14
E Wakeam, T K Varghese, N B Leighl, M Giuliani, S R G Finlayson, G E Darling
BACKGROUND: Practice guidelines from the National Comprehensive Cancer Network and the American Society of Clinical Oncology recommend pathologic mediastinal staging and surgical resection for patients with clinically node-negative T1/T2 small cell lung cancer (SCLC), but the extent to which surgery is used is unknown. We sought to assess trends and practice patterns in the use of surgery for SCLC. METHODS: T1 or T2N0M0 SCLC cases were identified in the National Cancer Database (NCDB), 2004-2013...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28577829/stereotactic-ablative-radiotherapy-for-early-stage-lung-cancer
#15
REVIEW
Jennifer L Shah, Billy W Loo
The rising incidence of early-stage lung cancer, particularly in medically inoperable patients, is anticipated because of the implementation of early detection strategies and population aging in the United States and worldwide. This mandates the development of noninvasive curative treatment approaches for this disease. Stereotactic ablative radiotherapy (SABR) has recently emerged as a standard of care for early-stage lung cancer in medically inoperable patients who cannot safely tolerate surgical lobectomy, the established standard for operable patients...
July 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28577182/economic-burden-of-cancer-among-patients-with-surgical-resections-of-the-lung-rectum-liver-and-uterus-results-from-a-us-hospital-database-claims-analysis
#16
Iftekhar Kalsekar, Chia-Wen Hsiao, Hang Cheng, Sashi Yadalam, Brian Po-Han Chen, Laura Goldstein, Andrew Yoo
OBJECTIVES: To determine hospital resource utilization, associated costs and the risk of complications during hospitalization for four types of surgical resections and to estimate the incremental burden among patients with cancer compared to those without cancer. METHODS: Patients (≥18 years old) were identified from the Premier Research Database of US hospitals if they had any of the following types of elective surgical resections between 1/2008 and 12/2014: lung lobectomy, lower anterior resection of the rectum (LAR), liver wedge resection, or total hysterectomy...
December 2017: Health Economics Review
https://www.readbyqxmd.com/read/28577160/fascial-reinforcement-fixing-the-bronchi-to-the-heart-its-anatomy-and-clinical-significance
#17
Kozo Nakanishi, Hidenori Goto, Tomokazu Ito
PURPOSE: The details of the mediastinal fascia have been scarcely described and the bronchopericardial membrane is the only known structure that is present between the bronchi and the pericardium. However, the anatomical description of this structure is unclear. This study aimed to investigate the fascial structures between the bronchi and the pericardium based on surgical findings. METHODS: The connective tissues in the mid-mediastinum were observed surgically when lung lobectomy, including mediastinal lymph node dissection for lung cancer, was performed at our institute from April 2011 to March 2016...
June 2, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28570755/personal-and-hospital-factors-associated-with-limited-surgical-resection-for-lung-cancer-in-hospital-mortality-and-complications-in-new-york-state
#18
Emanuela Taioli, Bian Liu, Daniel G Nicastri, Wil Lieberman-Cribbin, Emanuele Leoncini, Raja M Flores
BACKGROUND AND OBJECTIVES: Early stage lung cancer is generally treated with surgical resection. The objective of the study was to identify patient and hospital characteristics associated with the type of lung cancer surgical approach utilized in New York State (NYS), and to assess in-hospital adverse events. METHODS: A total of 33 960 lung cancer patients who underwent limited resection (LR) or lobectomy (L) were selected from the NYS Statewide Planning and Research Cooperative System database (1995-2012)...
June 1, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28562237/robotic-assisted-thoracoscopic-surgery-for-lung-resection-the-first-canadian-series
#19
Christine Fahim, Waël Hanna, Thomas Waddell, Yaron Shargall, Kazuhiro Yasufuku
BACKGROUND: Robotic surgery was introduced as a platform for minimally invasive lung resection in Canada in October 2011. We present the first Canadian series of robotic pulmonary resection for lung cancer. METHODS: Prospective databases at 2 institutions were queried for patients who underwent robotic resection for lung cancer between October 2011 and June 2015. To examine the effect of learning curves on patient and process outcomes, data were organized into 3 temporal tertiles, stratified by surgeon...
June 1, 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/28562171/modular-uniportal-video-assisted-thoracoscopic-lobectomy-and-lymphadenectomy-a-novel-pattern-of-endoscopic-lung-cancer-resection
#20
Yixin Cai, Ying Han, Ni Zhang, Shengling Fu, Yu Deng, Xiangning Fu
BACKGROUND: Since the development of the uniportal video-assisted thoracoscopic surgery (VATS) technique, the use of uniportal VATS has become increasingly popular for the surgical resection of non-small cell lung cancer (NSCLC). The objective of this study is to introduce a novel modularly designed surgical pattern for uniportal VATS for lung cancer resection and to investigate the safety, feasibility, and efficacy of this novel method. MATERIALS AND METHODS: The clinical data of NSCLC patients who underwent a curative uniportal VATS lobectomy between March 2015 and April 2016, including via the modular pattern (MP) and the conventional pattern (CP), were retrospectively collected and analyzed...
May 31, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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