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lobectomy in lung cancer

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https://www.readbyqxmd.com/read/28808224/off-label-use-of-crizotinib-as-a-neoadjuvant-treatment-for-a-young-patient-when-conventional-chemotherapy-gave-no-benefits-in-stage-iiia-non-small-cell-lung-cancer
#1
Delphine Dumont, Pascal Dô, Delphine Lerouge, Gaëtane Planchard, Marc Riffet, Catherine Dubos-Arvis, Serge Danhier, Radj Gervais
BACKGROUND The treatment of locally advanced non-small cell lung cancer involves a combination of chemotherapy, surgery, and radiotherapy. Each case is discussed and the best strategy is chosen individually, following international guidelines. CASE REPORT A 37-year-old man was diagnosed with locally advanced broncho-pulmonary adenocarcinoma (stage IIIA). The disease was stable after 2 cycles of cisplatin plus Navelbine used as neoadjuvant therapy. FISH analysis revealed an ALK rearrangement. The patient then received unlicensed crizotinib as second-line neoadjuvant treatment, which led to an almost complete radiological and metabolic response...
August 15, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28800867/impact-of-timing-of-lobectomy-on-survival-for-clinical-stage-ia-lung-squamous-cell-carcinoma
#2
Chi-Fu Jeffrey Yang, Hanghang Wang, Arvind Kumar, Xiaofei Wang, Matthew G Hartwig, Thomas A D'Amico, Mark F Berry
BACKGROUND: Because the relationship between timing of surgery following diagnosis of lung cancer and survival has not been precisely described, guidelines on what constitutes a clinically meaningful delay of resection of early-stage lung cancer do not exist. This study tested the hypothesis that increasing time between diagnosis and lobectomy for stage IA squamous cell carcinoma (SCC) was associated with worse survival. METHODS: The association between timing of lobectomy and survival for patients with clinical stage IA SCC in the National Cancer Data Base (2006-2011) was assessed using multivariable Cox proportional hazards analysis and restricted cubic spline (RCS) functions...
August 8, 2017: Chest
https://www.readbyqxmd.com/read/28799982/a-national-analysis-of-long-term-survival-following-thoracoscopic-versus-open-lobectomy-for-stage-i-non-small-cell-lung-cancer
#3
Chi-Fu Jeffrey Yang, Arvind Kumar, Jacob A Klapper, Matthew G Hartwig, Betty C Tong, David H Harpole, Mark F Berry, Thomas A D'Amico
OBJECTIVE: The objective of this study was to compare the long-term survival of open versus thoracoscopic (VATS) lobectomy for early stage non-small-cell lung cancer (NSCLC). BACKGROUND: Data from national studies on long-term survival for VATS versus open lobectomy are limited. METHODS: Outcomes of patients who underwent open versus VATS lobectomy for clinical T1-2, N0, M0 NSCLC in the National Cancer Data Base were evaluated using propensity score matching...
August 9, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28795361/metachronous-lung-cancer-clinical-characteristics-and-effects-of-surgical-treatment
#4
Adam Rzechonek, Piotr Błasiak, Beata Muszczyńska-Bernhard, Konrad Pawełczyk, Grzegorz Pniewski, Maciej Ornat, Jędrzej Grzegrzółka, Anna Brzecka
The occurrence of a second lung tumor after surgical removal of lung cancer usually indicates a lung cancer metastasis, but sometimes a new lesion proves to be a new primary lung cancer, i.e., metachronous lung cancer. The goal of the present study was to conduct a clinical evaluation of patients with metachronous lung cancer and lung cancer metastasis, and to compare the early and distant outcomes of surgical treatment in both cancer types. There were 26 age-matched patients with lung cancer metastases and 23 patients with metachronous lung cancers, who underwent a second lung cancer resection...
August 10, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28795040/successful-treatment-of-a-giant-emphysematous-bulla-with-an-endobronchial-valve-in-a-patient-with-contralateral-lung-cancer
#5
Chang-Seok Jeon, Jhingook Kim, Hojoong Kim
Patients with severe emphysema have a higher risk of developing lung cancer, and their surgical risk increases when emphysema is accompanied by a giant bulla. Here, we describe a patient who had an emphysematous giant bulla in the right upper lobe that was treated with an endobronchial valve placement. Subsequently, a cancerous lesion on the contralateral lung was successfully removed by lobectomy.
August 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28794837/use-of-sugammadex-in-lung-cancer-patients-undergoing-video-assisted-thoracoscopic-lobectomy
#6
Hyun Chul Cho, Jong Hwan Lee, Seung Cheol Lee, Sang Yoong Park, Jong Cheol Rim, So Ron Choi
BACKGROUND: This study aimed to retrospectively evaluate the use of sugammadex in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy. METHODS: Data were obtained from medical record review of patients who underwent VATS lobectomy from January 2013 to November 2014. Fifty patients were divided into two groups: the sugammadex group (group S, n = 19) was administered sugammadex 2 mg/kg, while the pyridostigmine group (group P, n = 31) received pyridostigmine 20 mg with glycopyrrolate 0...
August 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28791362/correlation-analysis-of-surfactant-protein-a-and-surfactant-protein-d-with-lung-function-in-exhaled-breath-condensate-from-lung-cancer-patients-with-and-without-copd
#7
Xuefeng Lin, Zhenlin Wu, Yichu Fan, Mingyou Chi, Xiaodong Wang, Xun Zhang, Daqiang Sun
Pulmonary surfactant protein A (SP‑A) and pulmonary surfactant protein D (SP‑D) are associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of the present study was to determine the correlation between SP‑A, SP‑D and lung function in patients with COPD. A total of 60 patients with lung cancer undergoing unilateral lobectomy were selected and divided into three groups, including a non‑COPD group (n=20), a COPD treatment group (n=20) and a COPD control group (n=20)...
August 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28790245/-surgical-case-of-pulmonary-enteric-adenocarcinoma
#8
Shin Shomura, Hitoshi Suzuki, Masaki Yada, Chiaki Kondo
A 59-year-old man consulted our hospital because of an abnormal shadow on a chest computed tomography, located in the right lower lobe. Fluorodeoxyglucose-positron emission tomography showed abnormal uptake in the tumor suggesting lung cancer and right lower lobectomy was performed. Pathological the tumor was diagnosed as lung cancer comprising tall columnar cells. Immunohistochemical staining was positive for TTF-1, CK-7 and CK-20. Postoperative screening of the abdomen revealed no suspicious primary lesion in the colon and the tumor was diagnosed as a pulmonary enteric adenocarcinoma...
August 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28781098/recent-advances-in-surgical-management-of-early-lung-cancer
#9
REVIEW
Shun-Mao Yang, Hsao-Hsun Hsu, Jin-Shing Chen
The broad application of low-dose computed tomography screening has resulted in the detection of many more cases of early lung cancer than ever before in modern history. Recent advances in the management of early-stage non-small cell lung cancer have focused on making therapy less traumatic, enhancing recovery, and preserving lung function. In this review, we discuss several new modalities associated with minimally invasive surgery for lung cancer. Firstly, less lung parenchyma resection via sublobar resection has become an acceptable alternative to lobectomy in patients with tumors less than 2 cm in size or with poor cardiopulmonary reserve...
August 3, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28760471/adjuvant-chemotherapy-does-not-confer-superior-survival-in-patients-with-atypical-carcinoid-tumors
#10
Kevin L Anderson, Michael S Mulvihill, Paul J Speicher, Babatunde A Yerokun, Brian C Gulack, Daniel P Nussbaum, David H Harpole, Thomas A D'Amico, Mark F Berry, Matthew G Hartwig
BACKGROUND: Although the use of adjuvant chemotherapy in patients with pathologically node-positive (pN+) atypical carcinoid tumor of the lung is an accepted practice, controversy exists about its use in pathologically node-negative (pN0) patients. Our aim was to determine whether a survival advantage exists in patients receiving chemotherapy postoperatively for pN0 or pN+ atypical carcinoid tumors of the lung. METHODS: Adult patients treated with lobectomy or pneumonectomy for pulmonary atypical carcinoid tumor were identified using the National Cancer Data Base, 2006 to 2011...
July 28, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28749044/video-assisted-thoracoscopic-lobectomy-after-percutaneous-coronary-intervention-in-lung-cancer-patients-with-concomitant-coronary-heart-disease
#11
Xin Li, YiLi Fu, JinBai Miao, Hui Li, Bin Hu
BACKGROUND: In recent years, based on clinical observations, the number of lung cancer patients with concomitant coronary heart disease (CHD) has gradually increased. However, because of the requirement of long-term anticoagulant therapy after percutaneous coronary intervention (PCI), some of these patients lose the opportunity for surgical treatment, resulting in tumor progression. The objective of this study was to determine the appropriate timing of video-assisted thoracic surgery (VATS) lobectomy after PCI without increasing perioperative cardiovascular risk...
July 27, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28741246/successful-resection-after-neoadjuvant-chemotherapy-for-esophageal-cancer-with-posterior-thoracic-paraaortic-lymph-node-metastasis-a-case-report-and-literature-review
#12
Yuji Shishido, Hiroshi Miyata, Keijirou Sugimura, Masaaki Motoori, Norikatsu Miyoshi, Masayoshi Yasui, Takeshi Omori, Masayuki Ohue, Yoshiyuki Fujiwara, Masahiko Yano
Metastasis to the posterior thoracic paraaortic lymph nodes rarely occurs in esophageal cancer, and a treatment strategy has not been established. We treated two cases of esophageal cancer with this type of metastasis; in both cases, we successfully performed surgical resection after neoadjuvant chemotherapy. In case 1, the patient received neoadjuvant chemotherapy, which consisted of docetaxel, cisplatin and 5-fluorouracil, and then underwent dissection of the posterior thoracic paraaortic lymph nodes. The left thoracic approach was used together with subtotal esophagectomy via a right thoracotomy...
July 24, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28740683/four-arms-robotic-assisted-pulmonary-resection-left-lower-lobectomy-how-to-do-it
#13
Alessandro Pardolesi, Luca Bertolaccini, Jury Brandolini, Piergiorgio Solli
Numerous published articles have shown the safety and efficacy of robotic lung resection, including lobectomy. The robotic approach offers similar survival rate to the open and video-assisted thoracoscopic surgery methods. Potential advantages provided by robotic technology, such as three-dimensional (3D) high-quality camera, wristed tools and ergonomic ease that seems to overcome certain video-assisted thoracic surgery (VATS) limits have been widely described. Several techniques have been developed by different surgeons to perform a robotic lobectomy...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740680/uniportal-video-assisted-thoracoscopic-right-upper-lobectomy-and-systemic-mediastinal-lymph-nodes-dissection
#14
Jia He, Dongjie Ma, Shanqing Li
Along with the progresses that have been made in techniques and instruments, uniportal video-assisted thoracoscopic surgery (VATS) became more and more popular. Here, we present the operation video of a 52-year-old female with early stage lung cancer in the right upper lobe (RUL), who underwent uniportal VATS right upper lobectomy and systemic mediastinal lymph nodes dissection performed by our team. The video demonstrated the Uniportal VATS techniques of hilar anatomy, bronchus and blood vessel separation, mediastinal lymph node areas exploration and en-bloc dissection...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740676/segmentectomy-versus-lobectomy-for-stage-i-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#15
Benedetta Bedetti, Luca Bertolaccini, Raffaele Rocco, Joachim Schmidt, Piergiorgio Solli, Marco Scarci
BACKGROUND: In recent years, many factors have revamped the interest in segmentectomies as preferred procedure for stage I non-small cell lung cancer (NSCLC). The aim of this systematic review and meta-analysis is to compare the outcomes of segmentectomy versus lobectomy regarding overall survival (OS) in the surgical treatment of stage I NSCLC, as stated in the conclusions of the largest studies conducted in this field and reported to date. METHODS: The searching strategy was developed in EMBASE, MEDLINE and Cochrane CENTRAL from 1990 until December 2016...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740675/feasibility-of-four-arm-robotic-lobectomy-as-solo-surgery-in-patients-with-clinical-stage-i-lung-cancer
#16
Seong Yong Park, Jee Won Suh, Kyoung Sik Narm, Chang Young Lee, Jin Gu Lee, Hyo Chae Paik, Kyoung Young Chung, Dae Joon Kim
BACKGROUND: This study was performed to investigate the feasibility of four-arm robotic lobectomy (FARL) as a solo surgical technique in patients with non-small cell lung cancer (NSCLC). Early outcome and long-term survival of FARL were compared with those of video-assisted thoracoscopic lobectomy (VATL). METHODS: Prospective enrollment of patients with clinical stage I NSCLC undergoing FARL or VATL (20 patients in each group) was planned. Interim analysis for early postoperative outcome was performed after the initial 10 cases in each group...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740665/decrease-in-performance-status-after-lobectomy-mean-poor-prognosis-in-elderly-lung-cancer-patients
#17
Yo Kawaguchi, Jun Hanaoka, Yasuhiko Oshio, Masayuki Hashimoto, Tomoyuki Igarashi, Yoko Kataoka, Ryosuke Kaku, Yuki Namura, Akira Akazawa
BACKGROUND: Surgery remains the best treatment for obtaining cure in patients with resectable lung cancer, regardless of age. In elderly patients, however, the presumed fear of decreased performance status (PS) after lobectomy has resulted in the delivery of sub-optimal cancer surgery. Surgical decision making for such patients would become easier if post-lobectomy survival benefits and changes in PS were well defined. METHODS: We reviewed patients aged 75 years or older who received lobectomy for non-small cell lung cancer (NSCLC) at our hospital between January 2004 and December 2014...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740431/what-we-know-about-surgical-therapy-in-early-stage-non-small-cell-lung-cancer-a-guide-for-the-medical-oncologist
#18
REVIEW
Sassine Ghanem, Sandy El Bitar, Sami Hossri, Chanudi Weerasinghe, Jean Paul Atallah
Lung cancer remains the leading cause of death in cancer patients. The gold standard for the treatment of early-stage non-small-cell lung cancer is lobectomy with mediastinal lymph-node dissection or systematic lymph-node sampling. The evidence behind this recommendation is based on the sole randomized controlled trial conducted to date, done by the Lung Cancer Study Group and published in 1995, which found a superiority for lobectomy over sublobar resection with regard to local recurrence rate and improved survival...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28732824/a-clinicopathological-study-of-surgically-resected-lung-cancer-in-patients-with-usual-interstitial-pneumonia
#19
Yasutaka Watanabe, Yoshinori Kawabata, Nobuyuki Koyama, Tomohiko Ikeya, Eishin Hoshi, Noboru Takayanagi, Shinichiro Koyama
BACKGROUND: The clinicopathological characteristics of lung cancer with concomitant usual interstitial pneumonia (UIP) are insufficiently understood. This study aimed to elucidate a characteristic pathological feature of lung cancer that develops in patients with UIP, with a focus on the location of its onset. METHODS: We reviewed surgically obtained specimens, including 547 tumors from 526 patients who underwent lobectomy for lung cancer. Surveyed patients were classified into three groups: patients with UIP (UIP group), patients with lung pathology other than UIP (non-UIP group), and patients without any associated lung pathology (normal group)...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28732271/a-rare-anomaly-of-the-right-superior-pulmonary-vein-report-of-a-case
#20
Yoshinobu Ichiki, Kesei Kakizoe, Takayuki Hamatsu, Taketoshi Suehiro, Makiko Koike, Fumihiro Tanaka, Keizo Sugimachi
INTRODUCTION: Although there are a lot of variations of pulmonary veins (PVs) including dangerous type that could cause serous complications during the surgery, limited information has been reported about these variations. We have experienced an extremely rare anomaly of the right superior PV. PRESENTATION OF CASE: A 74-year-old man patient with right lung cancer visited our hospital. Chest computed tomography (CT) revealed a pulmonary nodule in the right lower lobe...
July 6, 2017: International Journal of Surgery Case Reports
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