nuva ring

In Germany we observe an increasing number of unwanted teenage pregnancies associated with a consecutively escalating rate of abortions. The education at school, through parents and public media does not show sufficient prevention efficacy. One of the key issues in this context seems to be the discrepancy between time of education and premature sexual activity. Suitable contraceptives are required to meet individual needs and parameters of the adolescent. There are various suitable options as low dose oral contraception of the new generation, long-term depot contraceptives, the Nuva-Ring and future transdermal and subcutaneous contraceptives currently under evaluation...

The RAD18 gene of the yeast Saccharomyces cerevisiae encodes a protein with ssDNA binding activity that interacts with the ubiquitin-conjugating enzyme RAD6 and plays an important role in postreplication repair. We identified and characterized the putative mouse homolog of RAD18, designated mRAD18Sc. The mRAD18Sc open reading frame encodes a 509-amino-acid polypeptide that is strongly conserved in size and sequence between yeast and mammals, with specific conservation of the RING-zinc-finger and the classic zinc-finger domain...