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https://www.readbyqxmd.com/read/29332097/is-the-atopy-patch-test-reliable-in-the-evaluation-of-food-allergy-related-atopic-dermatitis
#1
Mahboubeh Mansouri, Elham Rafiee, Sepideh Darougar, Mehrnaz Mesdaghi, Zahra Chavoshzadeh
BACKGROUND: Aeroallergens and food allergens are found to be relevant in atopic dermatitis. The atopy patch test (APT) can help to detect food allergies in children with atopic dermatitis. This study evaluates if the APT is a valuable tool in the diagnostic workup of children with food allergy-related atopic dermatitis. METHODS: 42 children between 6 months and 12 years of age were selected at the Mofid Children Hospital. Atopic dermatitis was diagnosed, and the severity of the disease was determined...
January 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29332094/low-dose-oral-immunotherapy-using-low-egg-allergen-cookies-for-severe-egg-allergic-children-reduces-allergy-severity-and-affects-allergen-specific-antibodies-in-serum
#2
Akihiro Maeta, Marin Matsushima, Nozomi Muraki, Mariko Asano, Yuri Takaoka, Makoto Kameda, Kyoko Takahashi
BACKGROUND: We evaluated the safety and efficacy of low-egg-allergen cookies (LAC) as low-dose oral immunotherapy (OIT) in children with severe egg allergy. We also examined the relationship between mild desensitization by low-dose OIT and serum biomarkers of allergy. METHODS: We enrolled 13 children with egg allergy who could not receive OIT with hard-boiled egg white (EW). For 11 participants, OIT was carried out using LAC for 3-4 months. Open food challenges with hard-boiled EW and blood samplings were performed before and after OIT...
January 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29332023/autonomic-response-testing-compared-with-immunoglobulin-e-allergy-panel-test-results-preliminary-report
#3
Autumn Frandsen, Mark McClure, Myung Kyu Chung, Patrick J LaRiccia
Context • Chronically ill patients who have failed standard medical assessment and therapies are often assessed by integrative medical providers for atypical manifestations of allergies as the possible source or contributing factor(s) to their condition. Skin testing and immunoglobulin E (IgE) allergy panels increase the cost of care in these patients. Objective • The objective of this study was to determine the accuracy of autonomic response testing (ART) as compared with IgE allergy panel blood tests...
January 15, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29331617/asthma-predictive-index-in-relation-to-respiratory-mechanics-by-impulse-oscillometry-in-recurrent-wheezers
#4
T Arikoglu, S B Batmaz, D D Yildirim, Ö Tezol, G Bozlu, S Kuyucu
BACKGROUND: The identification of children who will have persistent asthma has become a focus of recent research. The aim of this study was to assess whether impulse oscillometry (IOS) has a diagnostic value to predict modified API (asthma predictive index) in pre-schoolers with recurrent wheezing. METHODS: Pre-school children aged 3-6 years with recurrent wheezing were enrolled. The study population was divided into two groups based on mAPI criteria. Lung function was assessed by IOS...
January 10, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29331514/employment-of-proteomic-and-immunological-based-methods-for-the-identification-of-catalase-as-novel-allergen-from-banana
#5
Jasna Nikolić, Andrijana Nešić, Skadi Kull, Frauke Schocker, Uta Jappe, Marija Gavrović-Jankulović
Diagnostic reagents based on food allergen extracts often lack sufficient sensitivity. The introduction of well characterized food allergens in molecular allergy diagnosis has been recognized as valid approach to circumvent unstandardized allergen extracts. Banana fruit (Musa acuminata) is a well-established allergen source which besides six characterized allergens, contains unidentified IgE reactive proteins whose clinical relevance remains undefined. By employment of a combinatorial peptide ligand library (CPLL) methodology with 2-D PAGE, mass spectrometric and 2-D immunoblot analysis, a novel allergen from banana fruit was detected in banana as catalase...
January 10, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29331473/a-randomized-trial-of-itraconazole-versus-prednisolone-in-acute-stage-abpa-complicating-asthma
#6
Ritesh Agarwal, Sahajal Dhooria, Inderpaul Singh Sehgal, Ashutosh N Aggarwal, Mandeep Garg, Biman Saikia, Digambar Behera, Arunaloke Chakrabarti
BACKGROUND AND AIMS: Whether itraconazole monotherapy is effective in the acute-stage of allergic bronchopulmonary aspergillosis (ABPA) remains unknown. Herein, we compare the efficacy and safety of itraconazole and prednisolone monotherapy in ABPA. METHODS: We randomized treatment-naïve subjects with ABPA complicating asthma (January 2012 to December 2013) to receive either oral itraconazole or prednisolone for four months. The study was not blinded. The primary outcomes were proportion of subjects showing composite response after six weeks, percentage decline in IgE after treatment, and numbers of subjects experiencing exacerbation...
January 10, 2018: Chest
https://www.readbyqxmd.com/read/29331065/component-resolved-diagnostics-to-direct-in-venom-immunotherapy-important-steps-towards-precision-medicine
#7
Simon Blank, Maria Beatrice Bilò, Markus Ollert
Stings of Hymenoptera can induce IgE-mediated systemic and even fatal allergic reactions. Venom-specific immunotherapy (VIT) is the only disease-modifying and curative treatment of venom allergy. However, choosing the correct venom for VIT represents a necessary prerequisite for efficient protection against further anaphylactic sting reactions after VIT. In the past, therapeutic decisions based on the measurement of specific IgE (sIgE) levels to whole venom extracts were not always straightforward, especially when the patient was not able to identify the culprit insect...
January 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29331049/prenatal-maternal-psychosocial-stress-and-offspring-s-asthma-and-allergic-disease-a-systematic-review-and-meta-analysis
#8
Catherine Flanigan, Aziz Sheikh, Audrey DunnGalvin, Bronwyn K Brew, Catarina Almqvist, Bright I Nwaru
BACKGROUND: Prenatal maternal stress may influence offspring's atopic risk through sustained cortisol secretion resulting from activation of the hypothalamic-pituitary-axis (HPA), leading to Th2-biased cell differentiation in the fetus. We undertook a systematic review and meta-analysis investigating the relationship between prenatal maternal psychosocial stress and risk of asthma and allergy in the offspring. METHODS: We searched 11 electronic databases from 1960 to 2016, search the grey literature, and contacted experts in the field...
January 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29331026/the-asthma-rhinitis-multimorbidity-is-associated-with-ige-polysensitization-in-adolescents-and-adults
#9
Valérie Siroux, Natalia Ballardini, Marion Soler, Christian Lupinek, Anne Boudier, Isabelle Pin, Jocelyne Just, Rachel Nadif, Josep M Anto, Erik Melen, Rudolf Valenta, Magnus Wickman, Jean Bousquet
BACKGROUND: Children with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remain poorly studied in adolescents and adults using defined allergen molecules. We investigated IgE sensitization patterns towards a broad panel of aeroallergen components in adults and adolescents with a focus on individuals with asthma and rhinitis multimorbidity. METHODS: IgE reactivity to 64 microarrayed aeroallergen molecules was determined with the MeDALL-chip in samples from the French EGEA study (n=840, age=40...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29329953/canine-macrophages-can-like-human-macrophages-be-in-vitro-activated-toward-the-m2a-subtype-relevant-in-allergy
#10
Ina Herrmann, Jelena Gotovina, Judit Fazekas-Singer, Michael B Fischer, Karin Hufnagl, Rodolfo Bianchini, Erika Jensen-Jarolim
The M2a subtype of macrophages plays an important role in human immunoglobulin E (IgE-mediated allergies) and other Th2 type immune reactions. In contrast, very little is known about these cells in the dog. Here we describe an in-vitro method to activate canine histiocytic DH82 cells and primary canine monocyte-derived macrophages (MDMs) toward the M2a macrophages using human cytokines. For a side-by-side comparison, we compared the canine cells to human MDMs, and the human monocytic cell line U937 activated towards M1-and M2a cells on the cellular and molecular level...
January 9, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29329877/-attitudes-towards-cow-s-milk-protein-allergy-management-by-spanish-gastroenterologist
#11
Alicia Isabel Pascual Pérez, Alejandra Méndez Sánchez, Óscar Segarra Cantón, Beatriz Espin Jaime, Santiago Jiménez Treviño, Carlos Bousoño García, Juan José Díaz Martín
INTRODUCTION: Food allergy is an increasing health problem in the developed world. Cow's milk protein is the main cause of food allergy in infants. Without an appropriate diagnostic workup, there is a high risk of both over- and underdiagnosis and therefore, over and undertreatment. The objective of our study was to analyze the variability in cow's milk protein allergy (CMPA) management by pediatric gastroenterologists in Spain. METHODS: A fifty item questionnaire, including open and closed items in a Likert's scale from 0 to 5, was drafted and distributed through the Spanish Society for Pediatric Gastroenterology, Hepatology and Nutrition (SEGHNP) e-mail list...
January 9, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29329856/effect-of-tyrosinase-aided-crosslinking-on-the-ige-binding-potential-and-conformational-structure-of-shrimp-metapenaeus-ensis-tropomyosin
#12
Ishfaq Ahmed, Liangtao Lv, Hong Lin, Zhenxing Li, Jiaju Ma, Chen Guanzhi, Lirui Sun, Lili Xu
The present study was performed to determine crosslinking and oxidative reactions catalyzed by tyrosinase (Tyr), caffeic acid (CA) and their combination with respect to IgE binding potential and conformational structure of shrimp tropomyosin (TM). Cross-links and IgE binding potentials were analyzed by SDS-PAGE, western blot and indirect ELISA. While structural changes were characterized using surface hydrophobicity, ultraviolet (UV), fluorescence and circular dichroism (CD) spectroscopies. Maximum reduction in the IgG (37...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29323160/glutathione-s-transferase-gst-of-american-cockroach-periplaneta-americana-classes-isoforms-and-allergenicity
#13
Nitat Sookrung, Onrapak Reamtong, Rojana Poolphol, Nitaya Indrawattana, Watee Seesuay, Nawannaporn Saelim, Pongsakorn Tantilipikorn, Chaweewan Bunnag, Wanpen Chaicumpa, Anchalee Tungtrongchitr
Insect glutathione S-transferases (GSTs) play important roles in insecticide/drug resistance and stress response. Medically, GSTs of house dust mites (Dermatophagoides pteronyssinus and Blomia tropicalis) and German cockroach (Blattella germanica) are human allergens. In this study, classes, isoforms and B-cell and allergenic epitopes of GST of American cockroach, Periplaneta americana, the predominant species in the tropics and subtropics were investigated for the first time. Enzymatically active native and recombinant P...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322510/lolium-perenne-peptide-immunotherapy-is-well-tolerated-and-elicits-a-protective-b-cell-response-in-seasonal-allergic-rhinitis-patients
#14
R Mösges, A F Koch, E Raskopf, J Singh, K Shah-Hosseini, B Hauswald, Y Yarin, F Corazza, L Haazen, S Pirotton, S Allekotte, G Zadoyan, T Legon, S R Durham, M H Shamji
BACKGROUND: Systemic allergic reactions are a risk for allergen immunotherapy that utilizes intact allergen preparations. We evaluated the safety, efficacy and immune mechanisms of short-course treatment with adjuvant-free Lolium perenne peptides (LPP) following a 6-week dose-escalation protocol. METHODS: In a prospective, dose-escalation study, 61 grass pollen-allergic patients received 2 subcutaneous injections of LPP once weekly for 6 weeks. Safety was assessed evaluating local reactions, systemic reactions and adverse events...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29320993/distribution-of-glomerular-diseases-in-taiwan-preliminary-report-of-national-renal-biopsy-registry-publication-on-behalf-of-taiwan-society-of-nephrology
#15
Hsien-Fu Chiu, Hung-Chun Chen, Kuo-Cheng Lu, Kuo-Hsiung Shu
BACKGROUND: Despite the development of biomarkers and noninvasive imaging tools, biopsy remains the only method for correctly diagnosing patients with unexplained hematuria, proteinuria and renal failure. Renal biopsy has been performed for several decades in Taiwan; however, a national data registry is still lacking until 2013. METHODS: The Renal Biopsy Registry Committee was established within the Taiwan Society of Nephrology in January 2013. A biopsy registry format, including basic demographic data, baseline clinical features, laboratory data, and clinical and pathological diagnosis was developed...
January 10, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29319896/skin-inflammation-exacerbates-food-allergy-symptoms-in-epicutaneously-sensitized-mice
#16
Akiko Kawasaki, Naohiro Ito, Hiroki Murai, Motoko Yasutomi, Hironobu Naiki, Yusei Ohshima
BACKGROUND: Cutaneous exposure to food antigen through impaired skin barrier has been shown to induce epicutaneous sensitization, thereby causing IgE-mediated food allergies. OBJECTIVE: We examined whether skin barrier impairment following epicutaneous sensitization exacerbates food allergies. METHODS: BALB/c mice were epicutaneously sensitized by repeated application of ovalbumin (OVA) to MC903-pretreated ear skin for 48 hours weekly and then intragastrically challenged with OVA...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29319891/teicoplanin-anaphylaxis-associated-with-surgical-prophylaxis
#17
Tariq Azamgarhi, Ashik Shah, Simon Warren
BACKGROUND: The rate of true anaphylaxis to teicoplanin is currently unknown. METHODS: A case-series including all suspected anaphylactic reactions attributed to teicoplanin anaphylaxis within a single institution over a 29-month period were categorised according to the probability of true IgE mediated anaphylaxis using previously published criteria. The number of patients who receive Teicoplanin was determined and used to calculate the rate of IgE mediated anaphylaxis...
January 10, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29319884/similar-localization-of-conformational-ige-epitopes-on-the-house-dust-mite-allergens-der-p-5-and-der-p-21-despite-limited-ige-cross-reactivity
#18
M Curin, T Garmatiuk, Y Resch-Marat, K W Chen, G Hofer, K Fauland, W Keller, W Hemmer, S Vrtala, M Focke-Tejkl, R Valenta
BACKGROUND: Due to high IgE recognition frequency and high allergenic activity, Der p 5 and Der p 21 are clinically important house dust mite (HDM) allergens. The objective of this study was to characterise the immunodominant IgE epitopes of Der p 5 and Der p 21 responsible for their high allergenic activity. METHODS: A panel of 12 overlapping peptides spanning the Der p 5 and Der p 21 sequence were synthesized to search for sequential IgE epitopes by direct testing for allergic patients ' IgE reactivity...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29319882/oral-myeloid-cells-uptake-allergoids-coupled-to-mannan-driving-th1-treg-responses-upon-sublingual-delivery-in-mice
#19
Irene Soria, Juan López-Relaño, Marcos Viñuela, José-Ignacio Tudela, Alba Angelina, Cristina Benito-Villalvilla, Carmen M Díez-Rivero, Bárbara Cases, Ana I Manzano, Enrique Fernández-Caldas, Miguel Casanovas, Oscar Palomares, José L Subiza
BACKGROUND: Polymerized allergoids coupled to nonoxidized mannan (PM-allergoids) may represent novel vaccines targeting dendritic cells (DCs). PM-allergoids are better captured by DCs than native allergens and favor Th1/Treg cell responses upon subcutaneous injection. Herein we have studied in mice the in vivo immunogenicity of PM-allergoids administered sublingually in comparison to native allergens. METHODS: Three immunization protocols (4-8 weeks long) were used in Balb/c mice...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29319881/systemic-il-2-anti-il-2ab-complex-combined-with-sublingual-immunotherapy-suppresses-experimental-food-allergy-in-mice-through-induction-of-mucosal-regulatory-t-cells
#20
Paola L Smaldini, Fernando Trejo, José L Cohen, Eliane Piaggio, Guillermo H Docena
Therapeutic tolerance restoration has been proven to modify food allergy in patients and animal models and although sublingual immunotherapy (SLIT) has showed promise, combined therapy may be necessary to achieve a strong and long-term tolerance. In this work, we combined SLIT with systemic administration of IL-2 associated with an anti-IL-2 monoclonal antibody (IL-2/anti-IL-2Ab complex or IL-2C) to reverse the IgE-mediated experimental allergy. Balb/c mice were sensitized with cholera toxin and milk proteins and orally challenged with allergen to elicit hypersensitivity reactions...
January 10, 2018: Allergy
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