Yu-Chen Wang, Yen Chin Koay, Calvin Pan, Zhiqiang Zhou, W H Wilson Tang, Jennifer Wilcox, Xinmin S Li, Alexia Zagouras, Francine Marques, Hooman Allayee, Federico E Rey, David M Kaye, John F O'Sullivan, Stanley L Hazen, Yang Cao, Aldons J Lusis
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a common but poorly understood form of heart failure, characterized by impaired diastolic function. It is highly heterogeneous with multiple comorbidities, including obesity and diabetes, making human studies difficult. METHODS: Metabolomic analyses in a mouse model of HFpEF showed that levels of indole-3-propionic acid (IPA), a metabolite produced by gut bacteria from tryptophan, were reduced in the plasma and heart tissue of HFpEF mice as compared with controls...
January 24, 2024: Circulation Research