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Nicotinamide AND diabetes

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https://www.readbyqxmd.com/read/29769421/low-placental-visfatin-expression-is-related-to-impaired-glycaemic-control-and-fetal-macrosmia-in-pregnancies-complicated-by-type-1-diabetes
#1
R Iciek, M Brazert, E Wender-Ozegowska, M Pietryga, J Brazert
Type 1 diabetes mellitus (T1DM) is still related to altered fetal growth and severe maternal complications. We studied the possible role of placental visfatin/nicotinamide phosphoribosyltransferase (NAMPT) in fetal development in T1DM pregnancies, the possible role of placental visfatin in fetal macrosomia. Sixty five pregnant women with T1DM and singleton pregnancy were qualified into the study. Placental visfatin expression was by analysed by RT-PCR. We demonstrated the lowest expression of placental visfatin in women who delivered neonates with birth weight NBW > 4000 g (0...
February 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29752433/palmitic-acid-but-not-high-glucose-induced-myocardial-apoptosis-is-alleviated-by-n%C3%A2-acetylcysteine-due-to-attenuated-mitochondrial-derived-ros-accumulation-induced-endoplasmic-reticulum-stress
#2
Yang He, Lingyun Zhou, Zhiqiang Fan, Shikun Liu, Weijin Fang
Pharmacological inhibition of reactive oxygen species (ROS) is a potential strategy to prevent diabetes-induced cardiac dysfunction. This study was designed to investigate precise effects of antioxidant N‑acetylcysteine (NAC) in alleviating diabetic cardiomyopathy (DCM). Echocardiography and histologic studies were performed 12 weeks after streptozocin injection. Protein levels involved in endoplasmic reticulum stress (ERS) and apoptosis were analyzed by western blotting in diabetic hearts or high-glucose (HG, 30 mM)- and palmitic acid (PA, 300 μM)-cultured neonatal rat cardiomyocytes (NRCMs)...
May 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29744272/antidiabetic-activity-of-mefloquine-via-glp-1-receptor-modulation-against-stz-na-induced-diabetes-in-albino-wistar-rats
#3
Rajnish Kumar Yadav, Jitendra K Rawat, Swetlana Gautam, Manjari Singh, Manish Kumar, Mohd Nazam Ansari, Subhadeep Roy, Abdulaziz S Saeedan, Gaurav Kaithwas
Mefloquine was retrieved as a glucagon -like peptide-1 receptor agonist and, therefore, evaluated for its antidiabetic potential against non-insulin-dependent diabetes mellitus (NIDDM) in experimental animals. NIDDM was induced by single intraperitoneal injection of streptozotocin and nicotinamide (60 + 110 mg/kg) in albino wistar rats. The experimental animals were scrutinised for electrocardiographic (ECG) and heart rate variability (HRV) factors to study the autonomic dysfunction along with blood glucose, serum insulin, and liver glycogen levels for glycemic control...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29732984/knockout-of-trpv1-exacerbates-left-ventricular-diastolic-dysfunction-induced-by-a-high-fat-diet-in-mice
#4
Beihua Zhong, Jack Rubinstein, Shuangtao Ma, Donna H Wang
BACKGROUND: Transient receptor potential vanilloid 1 (TRPV1) channels in sensory nerves have anti-oxidative properties and counteract obesity and diabetes that are associated with diastolic dysfunction with preserved ejection fraction. We tested the hypothesis that TRPV1 knockout exacerbates high-fat diet (HFD)-induced glucose intolerance and diastolic dysfunction. METHOD: Trpv1-/- and wild-type (WT) mice were fed chow diet or HFD for 20 weeks. Then, we performed the intraperitoneal glucose tolerance test, measured the heart function through transthoracic echocardiography and Langendorff heart perfusion system, analyzed cardiac histology, and measured the myocardial superoxide production and the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases...
May 3, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29710486/synergistic-and-non-synergistic-effects-of-salmon-calcitonin-and-omega-3-fatty-acids-on-antioxidant-anti-inflammatory-and-haematological-indices-in-diabetic-rats
#5
Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
The optimum therapy for the management of diabetes mellitus (DM) has been a controversial issue. Therefore, the study investigated the effects of salmon calcitonin (Sct) and/or omega-3 fatty acids {eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); EPA/DHA ratio?=?3/2} relative to metformin in diabetic male Wistar rats. Forty rats were used for this study. They were randomly divided into 8 groups of five (5) rats each, which were treated with single or combined administration of salmon calcitonin, N-3 and metformin...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29708459/betanin-exhibits-significant-potential-as-an-antihyperglycemic-and-attenuating-the-glycoprotein-components-in-streptozotocin-nicotinamide-induced-experimental-rats
#6
Indumathi Dhananjayan, Kathiroli Sujithra, Srinivasan Subramani, Veerasamy Vinothkumar
This study hypothesized to evaluate the effect of betanin, a chromoalkaloid on plasma and altered tissues glycoprotein components in streptozotocin - nicotinamide induced diabetic rats. Diabetes was induced by a single intraperitoneal (i.p.) injection of streptozotocin (45 mg/kg b.w.) dissolved in 0.1 M citrate buffer (pH 4.5) 15 min after the i.p. administration of nicotinamide (110 mg/kg b.w.). Experimental rats were administered betanin at the dose of 20 mg/kg b.w. and glibenclamide (600µg/kg b...
April 30, 2018: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29704151/extracellular-matrix-remodeling-and-modulation-of-inflammation-and-oxidative-stress-by-sulforaphane-in-experimental-diabetic-peripheral-neuropathy
#7
Passant E Moustafa, Noha F Abdelkader, Sally A El Awdan, Osama A El-Shabrawy, Hala F Zaki
The peripheral nervous system is one of many organ systems that can be profoundly impacted in diabetes mellitus. Diabetic peripheral neuropathy has a significant negative effect on patients' quality of life as it begins with loss of limbs' sensation and may result in lower limb amputation. This investigation aimed at exploring the effect of sulforaphane on peripheral neuropathy in diabetic rats. Experimental diabetes was induced through single intraperitoneal injections of nicotinamide (50 mg/kg) and streptozotocin (52...
April 27, 2018: Inflammation
https://www.readbyqxmd.com/read/29693190/liraglutide-reduces-hepatic-glucolipotoxicity%C3%A2-induced-liver-cell-apoptosis-through-nrf2-signaling-in-zucker-diabetic-fatty-rats
#8
Jun Guo, Cai Li, Chunxiao Yang, Bing Li, Jie Wei, Yajun Lin, Peng Ye, Gang Hu, Jian Li
The primary aim of the present study was to evaluate the effects of liraglutide on glucolipotoxicity‑induced liver cell apoptosis and the underlying mechanisms in Zucker diabetic fatty (ZDF) rats. The results revealed that liraglutide significantly decreased the body weight, hyperglycemia and hyperlipidemia of ZDF rats relative to those of Zucker lean (ZL) rats (P<0.05). Furthermore, the reduced liver cell apoptosis was observed in the ZDF rats following 6 weeks of liraglutide therapy. These data validated the beneficial effects of liraglutide on diabetic and obese ZDF rats...
April 23, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29693146/high-glucose-promotes-tumor-cell-proliferation-and-migration-in-lung-adenocarcinoma-via-the-rage%C3%A2-noxs-pathway
#9
Yuan-Fan Liao, Sui Yin, Zi-Qi Chen, Fan Li, Bo Zhao
Over the past few decades, it has been demonstrated that hyperglycemia can promote lung carcinoma growth, potentially through significantly increased glucose metabolism; however, the underlying mechanism remains to be fully elucidated. In the present study, treatment with a high concentration of glucose (HG) significantly promoted the proliferation and migration of A549 cells. Receptor for advanced glycation end‑products (RAGE) has previously been demonstrated to be associated with diabetes mellitus and oxidative stress, and nicotinamide adenine dinucleotide phosphate oxidases (NOXs) are considered to be initiating factors of oxidative stress...
April 23, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29671687/exploring-the-interactional-details-between-aldose-reductase-akr1b1-and-3-mercapto-5h-1-2-4-triazino-5-6-b-indole-5-acetic-acid-through-molecular-dynamics-simulations
#10
Jiu-Yu Zhan, Ke Ma, Qing-Chuan Zheng, Guang-Hui Yang, Hong-Xing Zhang
Aldose reductase (AKR1B1) has been considered as a significant target for designing drugs to counteract the development of diabetic complications. In the present study, molecular dynamics (MD) simulations and molecular mechanics generalized Born surface area (MM-GB/SA) calculations were performed to make sure which tautomer is the preferred one among three tautomeric forms (Mtia1, Mtia2, and Mtia3) of 3-Mercapto-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid (Mtia) for binding to AKR1B1. The overall structural features and the results of calculated binding free energies indicate that Mtia1 and Mtia2 have more superiority than Mtia3 in terms of binding to AKR1B1...
April 19, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29671019/lixisenatide-a-novel-glp-1-analog-protects-against-cerebral-ischemia-reperfusion-injury-in-diabetic-rats
#11
Rania G Abdel-Latif, Gehan H Heeba, Ashraf Taye, Mohamed M A Khalifa
Type 2 diabetes mellitus (T2DM) is a major risk factor for ischemic stroke accompanied by vascular dysfunction and poor cerebrovascular outcome. Lixisenatide is a glucagon like peptide-1 (GLP-1) analog that is recently used for T2DM treatment with established neuroprotective properties. This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury. T2DM-induced adult male Wistar rats were administered lixisenatide or glimepiride prior to induction of global cerebral I/R-induced injury...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29659293/solid-state-characterization-and-relative-formation-enthalpies-to-evaluate-stability-of-cocrystals-of-an-anti-diabetic-drug
#12
Naga Kiran Duggirala, Heather L Frericks Schmidt, Zhaohui Lei, Michael J Zaworotko, Joseph F Krzyzaniak, Kapildev K Arora
The current study integrates formation enthalpy and traditional slurry experiments to quickly assess the physical stability of cocrystal drug substance candidates for their potential to support drug development. Cocrystals of an anti-diabetic drug (GKA) with nicotinamide (NMA), vanillic acid (VLA) and ethyl vanillin (EVL) were prepared and characterized by powder X-ray diffractometry (PXRD), spectroscopic, and thermal techniques. The formation enthalpies of the cocrystals, and their physical mixtures (GKA + coformer) were measured by the Differential Scanning Calorimetry (DSC) method reported by Zhang et al...
April 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29655790/hdac11-deletion-reduces-fructose-induced-cardiac-dyslipidemia-apoptosis-and-inflammation-by-attenuating-oxidative-stress-injury
#13
Xiao-Di Fan, Lan-Lan Wan, Man Duan, Shan Lu
Diabetes mellitus (DM) is a risk factor for abnormal heart development, but the molecular mechanism remains obscure. Histone deacetylase 11 (HDAC11), the most recently identified histone deacetylase, is the sole member of class IV HDACs. However, its role in diabetic cardiac injury is still poorly understood. In the present study, we attempted to explore the effects of HDAC11 on fructose (Fru)-induced cardiac injury using the wild type (HDAC11+/+ ) and knockout (HDAC11-/- ) mice. The results indicated that HDAC11 was significantly expressed in human and mouse diabetic heart failure (DHF) hearts...
April 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29651204/ameliorative-effects-of-allium-sativum-extract-on-inos-gene-expression-and-no-production-in-liver-of-streptozotocin-nicotinamide-induced-diabetic-rats
#14
Nasrin Ziamajidi, Hamid Behrouj, Roghayeh Abbasalipourkabir, Fatemeh Lotfi
Diabetes mellitus (DM) is one of the most prevalent diseases in the world, which is strongly associated with liver dysfunction. Hyperglycemia, through an oxidative stress pathway, damages various tissues. Herbal medicine is a good candidate to ameliorate hyperglycemia and oxidative stress. In this study, the effects of aqueous Allium sativum (garlic) extract (AGE) on gene expression of inducible nitric oxide synthases (iNOS) and production of nitric oxide (NO) were evaluated in the liver tissue of diabetic rats...
April 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29643724/resolvin-d1-promotes-corneal-epithelial-wound-healing-and-restoration-of-mechanical-sensation-in-diabetic-mice
#15
Zhenzhen Zhang, Xiaoli Hu, Xia Qi, Guohu Di, Yangyang Zhang, Qian Wang, Qingjun Zhou
Purpose: To investigate the effect and mechanism of proresolving lipid mediator resolvin D1 (RvD1) on the corneal epithelium and the restoration of mechanical sensation in diabetic mice. Methods: Type 1 diabetes was induced in mice with intraperitoneal streptozocin injections. The healthy and diabetic mice underwent removal of the central corneal epithelium, and then 100 ng/ml RvD1 or its formyl peptide receptor 2 (FPR2) antagonist WRW4 was used to treat the diabetic mice...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29626513/effects-of-exercise-training-on-adipose-tissue-apelin-expression-in-streptozotocin-nicotinamide-induced-diabetic-rats
#16
Fahimeh Kazemi, Saleh Zahediasl
Apelin is an adipocyte-derived peptide that plays an important role in regulation of energy homoeostasis and decrease of insulin resistance. We investigated the effects of exercise training on adipose tissue apelin expression in streptozotocin-nicotinamide induced diabetic rats. In this experimental study, 38 male Wistar rats were assigned to 4 groups: sedentary diabetic, trained diabetic, sedentary non-diabetic and trained non-diabetic. Type 2 diabetes mellitus (T2DM) was induced by intraperitoneal injection of streptozotocin and nicotinamide in adult rats...
April 4, 2018: Gene
https://www.readbyqxmd.com/read/29626150/rac1-modulates-endothelial-function-and-platelet-aggregation-in-diabetes-mellitus
#17
Gabriele Giacomo Schiattarella, Albino Carrizzo, Federica Ilardi, Antonio Damato, Mariateresa Ambrosio, Michele Madonna, Valentina Trimarco, Marina Marino, Elena De Angelis, Silvio Settembrini, Cinzia Perrino, Bruno Trimarco, Giovanni Esposito, Carmine Vecchione
BACKGROUND: Vascular complications and abnormal platelet function contribute to morbidity and mortality in diabetes mellitus. We hypothesized that the Rho-related GTPase protein, Rac1, can influence both endothelial and platelet function and might represent a potential novel therapeutic target in diabetes mellitus. METHODS AND RESULTS: We used both in vitro and ex vivo approaches to test the effects of pharmacological inhibition of Rac1 during hyperglycemic condition...
April 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29623650/multi-scale-approach-for-the-evaluation-of-bone-mineralization-in-strontium-ranelate-treated-diabetic-rats
#18
Pedro Álvarez-Lloret, Juan Manuel Fernández, María Silvina Molinuevo, Agustina Berenice Lino, José Luis Ferretti, Ricardo Francisco Capozza, Ana María Cortizo, Antonio Desmond McCarthy
Long-term diabetes mellitus can induce osteopenia and osteoporosis, an increase in the incidence of low-stress fractures, and/or delayed fracture healing. Strontium ranelate (SrR) is a dual-action anti-osteoporotic agent whose use in individuals with diabetic osteopathy has not been adequately evaluated. In this study, we studied the effects of an oral treatment with SrR and/or experimental diabetes on bone composition and biomechanics. Young male Wistar rats (half non-diabetic, half with streptozotocin/nicotinamide-induced diabetes) were either untreated or orally administered 625 mg/kg/day of SrR for 6 weeks...
April 5, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29608898/canagliflozin-protects-against-non-alcoholic-steatohepatitis-in-type-2-diabetic-rats-through-zinc-alpha-2-glycoprotein-up-regulation
#19
Soad L Kabil, Nevertyty M Mahmoud
Elevated blood glucose and insulin resistance are triggering factors for non-alcoholic steatohepatitis (NASH). We investigated the effects of the Sodium Glucose co-Transporter 2 (SGLT2) inhibitor canagliflozin on NASH development in rats with type 2 diabetes mellitus as well as the possible underlying mechanisms and for the first time the effect of canagliflozin on the hepatic zinc-α2-glycoprotein (ZAG) levels. Rats were treated with nicotinamide and streptozotocin to reduce the insulin secretory capacity then fed high fat diet for 8 weeks...
June 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29606968/the-effect-of-betulinic-acid-on-leptin-adiponectin-hepatic-enzyme-levels-and-lipid-profiles-in-streptozotocin-nicotinamide-induced-diabetic-mice
#20
Akram Ahangarpour, Razieh Shabani, Yaghoob Farbood
Diabetes mellitus is developed by lack of insulin secretion or reduction of tissues sensitivity to insulin, which lead to serious complications. The aim of this study is to evaluate antihyperlipidemic effect of betulinic acid (BA) on streptozotocin-nicotinamide (STZ-NA) induced diabetic mice. In this experimental study, seventy adult male NMRI mice (20-25 g) were divided randomly into seven groups ( n = 10) of control, sham, diabetes, diabetes + BA (10, 20 and 40 mg/kg), and diabetes + metformin (200 mg/kg)...
April 2018: Research in Pharmaceutical Sciences
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