keyword
https://read.qxmd.com/read/38528644/sourdough-bread-as-nutritional-intervention-tool-for-improvement-of-cognitive-dysfunction-in-diabetic-rats
#1
JOURNAL ARTICLE
Doha A Mohamed, Karem Fouda, Hoda B Mabrok, Marwa E El-Shamarka, Ibrahim M Hamed
BACKGROUND: The current research targeted to study the impact of nutritional intervention by two sourdough breads in improvement of cognitive dysfunction in diabetic rats. METHODS: Type-2 diabetes was induced in rats by Streptozotocin-Nicotinamide (STZ-NC). Diabetic rats were fed on balanced diet or balanced diet containing 20% of sourdough bread I or II for a month. Lipid profile, oxidative stress, inflammatory markers and cognitive functions were assessed in all rats...
March 26, 2024: BMC Nutrition
https://read.qxmd.com/read/38528175/insulin-and-glycolysis-dependency-of-cardioprotection-by-nicotinamide-riboside
#2
JOURNAL ARTICLE
Y Xiao, Q Wang, H Zhang, R Nederlof, D Bakker, B A Siadari, M W Wesselink, B Preckel, N C Weber, M W Hollmann, B V Schomakers, M van Weeghel, C J Zuurbier
Decreased nicotinamide adenine dinucleotide (NAD+ ) levels contribute to various pathologies such as ageing, diabetes, heart failure and ischemia-reperfusion injury (IRI). Nicotinamide riboside (NR) has emerged as a promising therapeutic NAD+ precursor due to efficient NAD+ elevation and was recently shown to be the only agent able to reduce cardiac IRI in models employing clinically relevant anesthesia. However, through which metabolic pathway(s) NR mediates IRI protection remains unknown. Furthermore, the influence of insulin, a known modulator of cardioprotective efficacy, on the protective effects of NR has not been investigated...
March 25, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38509628/effects-of-physalis-peruviana-l-leaf-crude-extracts-on-blood-glucose-and-functional-biomarkers-in-streptozotocin-nicotinamide-induced-diabetic-rats
#3
JOURNAL ARTICLE
F M Kasali, J N Kadima, J B Safari, A G Agaba, J Tusiimire, B A Witika
Promoting antidiabetic phytomedicines necessitates evidence-based preclinical investigations, particularly in animal models. The present study investigated the validity of using the streptozotocin-nicotinamide-induced type 2 diabetic (STZ/NA-induced T2DM) model to evaluate the effects of Physalis peruviana leaf crude extracts on controlling blood glucose levels and regulating physiological biomarkers in rats. Aqueous and methanol extracts dissolved in carboxymethylcellulose 1% (100, 200, mg/kg/day) were administered orally to STZ/NA-induced T2DM rats alongside glibenclamide (5 mg/kg) as the standard drug for four weeks...
February 29, 2024: Die Pharmazie
https://read.qxmd.com/read/38508421/empagliflozin-reduces-the-adverse-effects-of-diabetes-mellitus-on-testicular-tissue-in-type-2-diabetic-rats-a-stereological-and-biochemical-study
#4
JOURNAL ARTICLE
Mina Kiani, Malek Soleimani Mehranjani, Mohammad Ali Shariatzadeh
Empagliflozin as an antioxidant decreases blood glucose and insulin resistance in type 2 diabetes mellitus. Base on the empagliflozin antioxidant properties we decided to investigate the its effects on the testis histological changes through stereological techniques and biochemical evaluations in T2 diabetes mellitus rats. Rats were divided into: control, diabetes mellitus (DM, streptozotocin + nicotinamide) and diabetes mellitus + empagliflozin (DM + EMPA, 10 mg/kg/day) groups...
March 18, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38507867/revealing-metabolic-and-biochemical-variations-via-1-h-nmr-metabolomics-in-streptozotocin-nicotinamide-induced-diabetic-rats-treated-with-metformin
#5
JOURNAL ARTICLE
Nur Khaleeda Zulaikha Zolkeflee, Pei Lou Wong, M Maulidiani, Nurul Shazini Ramli, Azrina Azlan, Ahmed Mediani, Chau Ling Tham, Faridah Abas
The increasing prevalence of lean diabetes has prompted the generation of animal models that mimic metabolic disease in humans. This study aimed to determine the optimum streptozotocin-nicotinamide (STZ-NA) dosage ratio to elicit lean diabetic features in a rat model. It also used a proton nuclear magnetic resonance (1 H NMR) urinary metabolomics approach to identify the metabolic effect of metformin treatment on this novel rat model. Three different STZ-NA dosage regimens (by body weight: Group A: 110 mg/kg NA and 45 mg/kg STZ; Group B: 180 mg/kg NA and 65 mg/kg STZ and Group C: 120 mg/kg NA and 60 mg/kg STZ) were administered to Sprague-Dawley rats along with oral metformin...
March 16, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38493252/the-porcine-islet-derived-organoid-showed-the-characteristics-as-pancreatic-duct
#6
JOURNAL ARTICLE
Naoaki Sakata, Gumpei Yoshimatsu, Ryo Kawakami, Kazuaki Nakano, Teppei Yamada, Akihiro Yamamura, Hiroshi Nagashima, Shohta Kodama
Organoid is a tissue-engineered organ-like structure that resemble as an organ. Porcine islet-derived organoid might be used as an alternative donor of porcine islet xenotransplantation, a promising therapy for severe diabetes. In this study, we elucidated the characteristics of porcine islet organoids derived from porcine islets as a cell source for transplantation. Isolated porcine islets were 3D-cultured using growth factor-reduced matrigel in organoid culture medium consist of advanced DMEM/F12 with Wnt-3A, R-spondin, EGF, Noggin, IGF-1, bFGF, nicotinamide, B27, and some small molecules...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38473844/nicotinamide-mononucleotide-nmn-works-in-type-2-diabetes-through-unexpected-effects-in-adipose-tissue-not-by-mitochondrial-biogenesis
#7
JOURNAL ARTICLE
Roua Gabriela Popescu, Anca Dinischiotu, Teodoru Soare, Ene Vlase, George Cătălin Marinescu
Nicotinamide mononucleotide (NMN) has emerged as a promising therapeutic intervention for age-related disorders, including type 2 diabetes. In this study, we confirmed the previously observed effects of NMN treatment on glucose uptake and investigated its underlying mechanisms in various tissues and cell lines. Through the most comprehensive proteomic analysis to date, we discovered a series of novel organ-specific effects responsible for glucose uptake as measured by the IPGTT: adipose tissue growing (suggested by increased protein synthesis and degradation and mTOR proliferation signaling upregulation)...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38467213/roles-of-sirt1-and-its-modulators-in-diabetic-microangiopathy-a-review
#8
REVIEW
Qi Jin, Tongtong Liu, Fang Ma, Tongfei Fu, Liping Yang, Huimin Mao, Yuyang Wang, Liang Peng, Ping Li, Yongli Zhan
Diabetic vascular complications include diabetic macroangiopathy and diabetic microangiopathy. Diabetic microangiopathy is characterised by impaired microvascular endothelial function, basement membrane thickening, and microthrombosis, which may promote renal, ocular, cardiac, and peripheral system damage in diabetic patients. Therefore, new preventive and therapeutic strategies are urgently required. Sirt1, a member of the nicotinamide adenine dinucleotide-dependent histone deacetylase class III family, regulates different organ growth and development, oxidative stress, mitochondrial function, metabolism, inflammation, and aging...
March 9, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38464965/identification-and-validation-of-nad-metabolism-related-biomarkers-in-patients-with-diabetic-peripheral-neuropathy
#9
JOURNAL ARTICLE
Chenhao Ye, Yuedong Fu, Xijie Zhou, Feiya Zhou, Xuwei Zhu, Yiheng Chen
BACKGROUND: The mechanism of Nicotinamide Adenine Dinucleotide (NAD+) metabolism-related genes (NMRGs) in diabetic peripheral neuropathy (DPN) is unclear. This study aimed to find new NMRGs biomarkers in DPN. METHODS: DPN related datasets GSE95849 and GSE185011 were acquired from the Gene Expression Omnibus (GEO) database. 51 NMRGs were collected from a previous article. To explore NMRGs expression in DPN and control samples, differential expression analysis was completed in GSE95849 to obtain differentially expressed genes (DEGs), and the intersection of DEGs and NMRGs was regarded as DE-NMRGs...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38451017/dapagliflozin-reduces-urinary-kidney-injury-biomarkers-in-chronic-kidney-disease-irrespective-of-albuminuria-level
#10
JOURNAL ARTICLE
Junghyun Cho, Seung Whan Doo, Nayoung Song, Minsul Lee, Haekyung Lee, Hyongnae Kim, Jin Seok Jeon, Hyunjin Noh, Soon Hyo Kwon
The beneficial effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors in patients with chronic kidney disease (CKD) with low albuminuria levels have not been established. This study aimed to compare the effects of dapagliflozin on kidney injury biomarkers in patients with CKD stratified by albuminuria level. We prospectively enrolled healthy volunteers (HVs; n = 20) and patients with CKD (n = 54) with and without diabetes mellitus. Patients with CKD were divided into two age-matched and sex-matched subgroups according to urinary albumin-creatinine ratio (uACR) levels (<300 mg/g and ≥300 mg/g)...
March 7, 2024: Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38446387/nicotinamide-protects-against-diabetic-kidney-disease-through-regulation-of-sirt1
#11
JOURNAL ARTICLE
Yeping Yang, Jinya Huang, Lijie Xie, Yilin Wang, Shizhe Guo, Meng Wang, Xiaoqing Shao, Wenjuan Liu, Yi Wang, Qin Li, Xia Wu, Zhaoyun Zhang, Fangfang Zeng, Wei Gong
PURPOSE: To investigate the effect of nicotinamide (Nam) on diabetic kidney disease (DKD) in mice and explore its mechanism. METHODS: Thirty DBA/2 J mice were randomly assigned to three groups. After 8 weeks of hyperglycemia induced by streptozocin (STZ), Nam and saline were administrated to STZ + Nam and STZ + NS mice, respectively, for 8 weeks. Non-diabetic mice (NDM) were used as control group. Twenty In2-/- Akita mice were randomly divided into two groups...
March 6, 2024: Endocrine
https://read.qxmd.com/read/38434722/adipose-mesenchymal-stem-cell-derived-exosomes-promote-skin-wound-healing-in-diabetic-mice-by-regulating-epidermal-autophagy
#12
JOURNAL ARTICLE
Zhe Wang, Haiyue Ren, Peng Su, Feng Zhao, Qiqi Zhang, Xing Huang, Cai He, Quan Wu, Zitong Wang, Jiajie Ma
BACKGROUND: Adipose mesenchymal stem cell-derived exosomes (ADSC-Exos) have great potential in the field of tissue repair and regenerative medicine, particularly in cases of refractory diabetic wounds. Interestingly, autophagy plays a role in wound healing, and recent research has demonstrated that exosomes are closely associated with intracellular autophagy in biogenesis and molecular signaling mechanisms. Therefore, this study aimed to investigate whether ADSC-Exos promote the repair of diabetic wounds by regulating autophagy to provide a new method and theoretical basis for the treatment of diabetic wounds...
2024: Burns and Trauma
https://read.qxmd.com/read/38422177/glycolysis-mediated-activation-of-v-atpase-by-nicotinamide-mononucleotide-ameliorates-lipid-induced-cardiomyopathy-by-repressing-the-cd36-tlr4-axis
#13
JOURNAL ARTICLE
Shujin Wang, Yinying Han, Ruimin Liu, Mengqian Hou, Dietbert Neumann, Jun Zhang, Fang Wang, Yumeng Li, Xueya Zhao, Francesco Schianchi, Chao Dai, Lizhong Liu, Miranda Nabben, Jan F C Glatz, Xin Wu, Xifeng Lu, Xi Li, Joost J F P Luiken
BACKGROUND: Chronic overconsumption of lipids followed by their excessive accumulation in the heart leads to cardiomyopathy. The cause of lipid-induced cardiomyopathy involves a pivotal role for the proton-pump vacuolar-type H+ -ATPase (v-ATPase), which acidifies endosomes, and for lipid-transporter CD36, which is stored in acidified endosomes. During lipid overexposure, an increased influx of lipids into cardiomyocytes is sensed by v-ATPase, which then disassembles, causing endosomal de-acidification and expulsion of stored CD36 from the endosomes toward the sarcolemma...
March 2024: Circulation Research
https://read.qxmd.com/read/38410452/illuminating-the-functions-of-the-understudied-fructosamine-3-kinase-fn3k-using-a-multi-omics-approach-reveals-new-links-to-lipid-carbon-and-co-factor-metabolic-pathways
#14
Natarajan Kannan, Safal Shrestha, Rahil Taujale, Samiksha Katiyar
Fructosamine-3-kinases (FN3Ks) are a conserved family of repair enzymes that phosphorylate reactive sugars attached to lysine residues in peptides and proteins. Although FN3Ks are present across the tree of life and share detectable sequence similarity to eukaryotic protein kinases, the biological processes regulated by these kinases are largely unknown. To address this knowledge gap, we leveraged the FN3K CRISPR Knock-Out (KO) cell line alongside an integrative multi-omics study combining transcriptomics, metabolomics, and interactomics to place these enzymes in a pathway context...
February 16, 2024: Research Square
https://read.qxmd.com/read/38409700/nad-pathways-in-diabetic-coronary-heart-disease-unveiling-the-key-players
#15
JOURNAL ARTICLE
Yuan Liu, Wenjing Zhan, Lexun Wang, Weixuan Wang
Diabetic coronary heart disease is a global medical problem that poses a serious threat to human health, and its pathogenesis is complex and interconnected. Nicotinamide adenine dinucleotide (NAD) is an important small molecule used in the body that serves as a coenzyme in redox reactions and as a substrate for non-redox processes. NAD levels are highly controlled by various pathways, and increasing evidence has shown that NAD pathways, including NAD precursors and key enzymes involved in NAD synthesis and catabolism, exert both positive and negative effects on the pathogenesis of diabetic coronary heart disease...
February 22, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38408417/sirt3-alleviates-high-glucose-induced-chondrocyte-injury-through-the-promotion-of-autophagy-and-suppression-of-apoptosis-in-osteoarthritis-progression
#16
JOURNAL ARTICLE
Xuezhong Wang, Zilin Liu, Shuang Deng, Jianlin Zhou, Xuyang Li, Jun Huang, Junwen Chen, Chuang Ji, Yu Deng, Yong Hu
A growing amount of epidemiological evidence proposes diabetes mellitus (DM) to be an independent risk factor for osteoarthritis (OA). Sirtuin 3 (SIRT3), which is mainly located in mitochondria, belongs to the family of nicotinamide adenine dinucleotide (NAD+ )-dependent protein deacetylases and is involved in the physiological and pathological processes of cell regulation. The aim of this study was to investigate the effects of SIRT3 on diabetic OA and underlying mechanisms in the prevention of type 2 DM (T2DM)-induced articular cartilage damage...
February 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38396842/protective-effect-of-betulin-on-streptozotocin-nicotinamide-induced-diabetes-in-female-rats
#17
JOURNAL ARTICLE
Feyisayo O Adepoju, Ksenia V Sokolova, Irina F Gette, Irina G Danilova, Mikhail V Tsurkan, Alicia C Mondragon, Elena G Kovaleva, Jose Manuel Miranda
Type 2 diabetes is characterized by hyperglycemia and a relative loss of β-cell function. Our research investigated the antidiabetic potential of betulin, a pentacyclic triterpenoid found primarily in birch bark and, intriguingly, in a few marine organisms. Betulin has been shown to possess diverse biological activities, including antioxidant and antidiabetic activities; however, no studies have fully explored the effects of betulin on the pancreas and pancreatic islets. In this study, we investigated the effect of betulin on streptozotocin-nicotinamide (STZ)-induced diabetes in female Wistar rats...
February 10, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38351579/a-bioenergetically-active-ploy-glycerol-sebacate-based-multiblock-hydrogel-improved-diabetic-wound-healing-through-revitalizing-mitochondrial-metabolism
#18
JOURNAL ARTICLE
Xin Qi, Chenjun Liu, Jingyi Si, Bohao Yin, Jingjing Huang, Xin Wang, Jinghuan Huang, Hui Sun, Changfeng Zhu, Wei Zhang
Diabetic wounds impose significant burdens on patients' quality of life and healthcare resources due to impaired healing potential. Factors like hyperglycemia, oxidative stress, impaired angiogenesis and excessive inflammation contribute to the delayed healing trajectory. Mounting evidence indicates a close association between impaired mitochondrial function and diabetic complications, including chronic wounds. Mitochondria are critical for providing energy essential to wound healing processes. However, mitochondrial dysfunction exacerbates other pathological factors, creating detrimental cycles that hinder healing...
February 13, 2024: Cell Proliferation
https://read.qxmd.com/read/38322911/comparison-of-the-anti-diabetic-effects-of-various-grain-and-legume-extracts-in-high-fat-diet-and-streptozotocin-nicotinamide-induced-diabetic-rats
#19
JOURNAL ARTICLE
Eunwoo Jeong, Youjin Baek, Hyun-Joo Kim, Hyeon Gyu Lee
The anti-diabetic properties of whole groats and dietary fibers from various grains and legumes are well known. Nevertheless, studies on the anti-diabetic effects of their extracts are limited, and it is difficult to compare their efficacy. This study investigated the anti-diabetic potential of ethanol extracts from oats (OE), sorghum (SE), foxtail millet (FE), proso millet (PE), adzuki bean (AE), and black soybean (BE) in a high-fat diet and streptozotocin-nicotinamide-induced diabetic rat models. The extracts, obtained using 99...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38300831/continuous-ketone-monitoring-via-wearable-microneedle-patch-platform
#20
JOURNAL ARTICLE
Chochanon Moonla, Maria Reynoso, Ana Casanova, An-Yi Chang, Omeed Djassemi, Aishwarya Balaje, Amal Abbas, Zhengxing Li, Kuldeep Mahato, Joseph Wang
Ketone bodies (KBs), especially β-hydroxybutyrate (BHB), have gained tremendous attention as potential biomarkers as their presence in bodily fluids is closely associated with health and wellness. While a variety of blood fingerstick test strips are available for self-testing of BHB, there are major needs for wearable devices capable of continuously tracking changing BHB concentrations. To address these needs, we present here the first demonstration of a wearable microneedle-based continuous ketone monitoring (CKM) in human interstitial fluid (ISF) and illustrate its ability to closely follow the intake of ketone drinks...
February 1, 2024: ACS Sensors
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