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Nicotinamide AND diabetes

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https://www.readbyqxmd.com/read/28748119/uric-acid-in-the-pathogenesis-of-metabolic-renal-and-cardiovascular-diseases-a-review
#1
REVIEW
Usama A A Sharaf El Din, Mona M Salem, Dina O Abdulazim
The association between uric acid (UA) on one side and systemic hypertension (Htn), dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular disease (CVD) on the other side is well recognized. However, the causal relationship between UA and these different clinical problems is still debatable. The recent years have witnessed hundreds of experimental and clinical trials that favored the opinion that UA is a probable player in the pathogenesis of these disease entities. These studies disclosed the strong association between hyperuricemia and metabolic syndrome (MS), obesity, Htn, type 2 diabetes mellitus (DM), non-alcoholic fatty liver disease, hypertriglyceridemia, acute kidney injury, chronic kidney disease (CKD), coronary heart disease (CHD), heart failure and increased mortality among cardiac and CKD patients...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28747214/culturing-and-transcriptome-profiling-of-progenitor-like-colonies-derived-from-adult-mouse-pancreas
#2
Dongshen Ma, Shanshan Tang, Jing Song, Qiong Wu, Fangfang Zhang, Yun Xing, Yi Pan, Yanfeng Zhang, Jingwei Jiang, Yubin Zhang, Liang Jin
BACKGROUND: Transplantation of insulin-producing cells is considered an important diabetes therapy. Many research studies have shown that insulin-producing cells can be derived from the in-vitro cultured pancreatic colonies with self-renewal ability and multilineage potential. Even though these progenitor-like colonies have been prepared from adult pancreas cells, the efficient culture method is hardly established and regulation of the colonies is rarely known. We confirmed previously that single cells acquired from adult mouse pancreas could form cyst-like colonies in a 3D semi-solid system containing Matrigel and methylcellulose...
July 26, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28744906/effects-of-combination-of-mitiglinide-with-various-oral-antidiabetic-drugs-in-streptozotocin-nicotinamide-induced-type-2-diabetic-rats-and-zucker-fatty-rats
#3
Kenji Akahane, Kazuma Ojima, Ayaka Yokoyama, Toshihiro Inoue, Sumiyoshi Kiguchi, Satoshi Tatemichi, Hiroo Takeda, Yohsuke Imai
We examined the effects of combining the rapid insulin secretagogue, mitiglinide, with various oral hypoglycemic drugs including biguanides, pioglitazone, α-glucosidase inhibitors, and sodium-glucose co-transporter 2 inhibitors in a rat model of type 2 diabetes. The oral glucose tolerance test (OGTT) using glucose, sucrose, or a liquid meal was used to compare the effects of mitiglinide with those of the four oral hypoglycemic drugs and examine their combined effects on blood glucose levels and insulin secretion in the rat model...
July 26, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28736546/zb-16-a-novel-gpr119-agonist-relieves-the-severity-of-streptozotocin-nicotinamide-induced-diabetes-in-rats
#4
Ivan N Tyurenkov, Denis V Kurkin, Dmitry A Bakulin, Elena V Volotova, Mikhail A Chafeev, Alexey V Smirnov, Evgeny I Morkovin
GPR119 is involved in the regulation of incretin and insulin secretion, so the GPR119 agonists have been suggested as novel antidiabetic medications. The purpose of this work was to assess the influence of novel GPR119 agonist ZB-16 on the glucose utilization, insulin, and glucagon-like peptide-1 (GLP-1) secretion and the morphology of pancreas in rats with streptozotocin-nicotinamide-induced diabetes. 45 male Wistar rats were used in the study. The criteria of streptozotocin-nicotinamide-induced diabetes were blood glucose levels of 9-14 mmol/l measured in fasting conditions on the third day since administration of streptozotocin (65 mg/kg) and nicotinamide (230 mg/kg)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28722418/urine-metabonomics-reveals-early-biomarkers-in-diabetic-cognitive-dysfunction
#5
Lili Song, Pengwei Zhuang, Mengya Lin, Mingqin Kang, Hongyue Liu, Yuping Zhang, Zhen Yang, Yunlong Chen, Yanjun Zhang
Recently, increasing attention has been paid to diabetic encephalopathy which is one of frequent diabetic complications and affects nearly 30% diabetics. Since cognitive dysfunction from diabetic encephalopathy might develop irreversible dementia, early diagnosis and detection of this disease is of great significance for its prevention and treatment. This study is to investigate the early specific metabolites biomarkers in the urine prior to the onset of diabetic cognitive dysfunction (DCD) by using metabolomics technology...
July 19, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28699485/change-in-serum-nampt-levels-and-its-significances-in-diabetic-nephropathy-patients
#6
Xiaoyu Ma, Li An, Qiuyue Wang
BACKGROUND: Nicotinamide phosphoribosyltransferase(Nampt) has a variety of biological effects, which can participate in the development of inflammatory diseases, metabolism diseases and chronic kidney disease, et al. However, he role of Nampt in T2DM and DN are still controversial. OBJECTIVE: To investigate changes in serum Nampt levels and its significance in diabetic nephropathy (DN). METHOD: A total of 321 type 2 diabetes (T2DM) were divided into normal albuminuria group (NA, n=110), microalbuminuria group (MA, n=106) and large amount of albuminuria group (LA, n=105)...
July 11, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28698746/study-of-visfatin-level-in-type-1-diabetic-children-and-adolescents
#7
Mona H El Samahi, Nagwa Abdallah Ismail, Randa M Matter, Abeer Selim, Alshaymaa Ahmed Ibrahim, Walaa Nabih
BACKGROUND: Visfatin is an intracellular enzyme, known as nicotinamide phosphoribosyltransferase (Nampt) and pre-B-cell colony-enhancing factor (PBEF-1). It has insulin-mimetic effects and lowers plasma glucose levels. AIM: The aim of the work was to assess serum concentration of Visfatin in type 1 diabetic children and adolescents and study its relationships with duration of diabetes, body mass index (BMI), glycemic control, insulin dosage, lipid profile and microvascular complications...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28677319/effect-of-the-polyphenol-rich-ethyl-acetate-fraction-from-the-leaves-of-lycium-chinense-miller-on-oxidative-stress-dyslipidemia-and-diabetes-mellitus-in-streptozotocin-nicotinamide-induced-diabetic-rats
#8
Opeyemi J Olatunji, Hongxia Chen, Yifeng Zhou
Lycium chinense Miller, popularly known as boxthorn, is a plant that is traditionally used for treating night sweat, cough, inflammation and diabetes mellitus. However, the leaves have received little or no attention despite their potentials as a potent therapeutic agent. This study was aimed at investigating the hypoglycemic and hypolipidemic effects of the polyphenols-rich ethyl acetate fraction from the leaves of Lycium chinense Miller on streptozotocin-nicotinamide induced diabetic rats. The ethyl acetate fraction (LFE) was selected and orally gavaged at 100, 200 and 400 mg/kg dose to streptozotocin (STZ)-nicotinamide induced diabetic rats...
July 4, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28673757/anti-inflammatory-anti-apoptotic-and-pro-proliferative-effects-of-vitis-vinifera-seed-ethanolic-extract-in-the-liver-of-streptozotocin-nicotinamide-induced-diabetes-in-male-rats
#9
Nelli Giribabu, Kamarulzaman Karim, Eswar Kumar Kilari, Normadiah M Kassim, Naguib Salleh
OBJECTIVES: Consumption of Vitis vinifera seed has been reported to ameliorate liver pathology in diabetes mellitus; however, the mechanisms underlying its effects remain unknown. In this study, the anti-inflammatory, anti-apoptotic and pro-proliferative effects of the ethanolic seed extract of V. vinifera (VVSEE) in the liver in cases of diabetes were identified. METHODS: Adult male rats with streptozotocin-nicotinamide-induced diabetes were given 50, 100 or 200 mg/kg body weight VVSEE orally for 28 days...
June 30, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28672961/salidroside-inhibits-high-glucose-induced-proliferation-of-vascular-smooth-muscle-cells-via-inhibiting-mitochondrial-fission-and-oxidative-stress
#10
Xinyu Zhuang, Alimujiang Maimaitijiang, Yong Li, Haiming Shi, Xiaofei Jiang
The mitochondria are highly dynamic organelles, carefully maintaining network homeostasis by regulating mitochondrial fusion and fission. Mitochondrial dynamics are involved in the regulation of a variety of pathophysiological processes, including cell proliferation. Oxidative stress serves an important role in the remodeling of arterial vascular tissue in diabetic patients by affecting the proliferation of vascular smooth muscle cells (VSMCs). Salidroside is the primary active component of Rhodiola rosea and has been demonstrated to be an antioxidant with cardio- and vascular-protective effects, in addition to improving glucose metabolism...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28662699/hypoglycaemic-activity-of-mathurameha-a-thai-traditional-herbal-formula-aqueous-extract-and-its-effect-on-biochemical-profiles-of-streptozotocin-nicotinamide-induced-diabetic-rats
#11
Kullacha Chayarop, Penchom Peungvicha, Rungravi Temsiririrkkul, Yuvadee Wongkrajang, Wongsatit Chuakul, Piyanuch Rojsanga
BACKGROUND: The Thai traditional herbal formula-Mathurameha, consisting of 26 medicinal plants, has been used as an alternative and complementary medicine for diabetes treatment in Wangnamyen Hospital, Thailand. To provide scientific evidences on the efficacy and safety of this herbal formula, in vivo hypoglycaemic activity, effect on serum biochemical profiles and acute toxicity were investigated. METHODS: Experimental type 2 diabetes was induced in male Sprague-Dawley rats by intraperitoneal injection of nicotinamide 15 min prior to intravenous injection of streptozotocin...
June 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28661724/sirt1-and-sirt6-signaling-pathways-in-cardiovascular-disease-protection
#12
Nunzia D'Onofrio, Luigi Servillo, Maria Luisa Balestrieri
SIGNIFICANCE: Oxidative stress represents the common hallmark of pathological conditions associated with cardiovascular disease (CVD), including atherosclerosis, heart failure, hypertension, aging, diabetes, and other vascular system-related diseases. The sirtuin (SIRT) family, comprising seven proteins (SIRT1-SIRT7) sharing a highly conserved nicotinamide adenine dinucleotide (NAD(+))-binding catalytic domain, attracted a great attention for the past few years as stress adaptor and epigenetic enzymes involved in the cellular events controlling aging-related disorder, cancer, and CVD...
June 29, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28655312/transplantation-of-human-fetal-pancreatic-progenitor-cells-ameliorates-renal-injury-in-streptozotocin-induced-diabetic-nephropathy
#13
Yongwei Jiang, Wenjian Zhang, Shiqing Xu, Hua Lin, Weiguo Sui, Honglin Liu, Liang Peng, Qing Fang, Li Chen, Jinning Lou
BACKGROUND: Diabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Pancreas or islet transplantation has been reported to prevent the development of DN lesions and ameliorate or reverse existing glomerular lesions in animal models. Shortage of pancreas donor is a severe problem. Islets derived from stem cells may offer a potential solution to this problem. OBJECTIVE: To evaluate the effect of stem cell-derived islet transplantation on DN in a rat model of streptozotocin-induced DM...
June 27, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28647274/sonic-hedgehog-pathway-suppression-and-reactivation-accelerates-differentiation-of-rat-adipose-derived-mesenchymal-stromal-cells-toward-insulin-producing-cells
#14
Dian Dayer, Mahmoud Hashemi Tabar, Eskandar Moghimipour, Mohammad Reza Tabandeh, Ata A Ghadiri, Elham Allah Bakhshi, Mahmoud Orazizadeh, Mohammad Ali Ghafari
BACKGROUND AIMS: Sonic hedgehog (Shh) is an intercellular signaling molecule that regulates pancreas development in mammals. Manipulation of Shh signaling pathway can be used as reliable approach to improve the generation of functional insulin-producing cells (IPCs) from mesenchymal stromal cells (MSCs). METHODS: In the present study, a novel differentiation protocol was used to produce IPCs from adipose tissue-derived MSCs (ATDMSCs) based on sequential inhibition and reactivation of Shh pathway...
June 21, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28632450/combinations-of-activin-a-or-nicotinamide-with-the-pancreatic-transcription-factor-pdx1-support-differentiation-of-human-amnion-epithelial-cells-toward-a-pancreatic-lineage
#15
Shruti Balaji, Yu Zhou, Emmanuel C Opara, Shay Soker
The differentiation of multipotent stem cells toward a pancreatic lineage provides us with an alternative cell-based therapeutic approach to type 1 diabetes and enables us to study pancreas development. The current study aims to study the effect of growth factors such as activin A or nicotinamide, alone and in combinations with the transcription factor, PDX1 (pancreatic and duodenal homeobox-1), on human amnion epithelial cells (hAECs) toward a pancreatic lineage. Ectopic expression of Pdx1 followed by treatment of hAECs with nicotinamide for 4 days resulted in strong induction of pancreatic endoderm and pancreatic progenitor genes, including NKX6...
June 20, 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28628926/synthesis-characterisation-molecular-docking-anti-microbial-and-anti-diabetic-screening-of-substituted-4-indolylphenyl-6-arylpyrimidine-2-imine-derivatives
#16
Veerasamy Ramya, Santhirakasu Vembu, Ganesan Ariharasivakumar, Manathusamy Gopalakrishnan
The purpose of the research is to synthesise a novel series of (E)-2-(4-(1H-indol-3-yl)-6-p-substituted phenylpyrimidin-2-yl)dimethylguanidine derivatives since 3-(1H-indol-3-yl)-1-p-substituted phenylprop-2-en-1-one and evaluate their molecular docking studies, antimicrobial, and anti-diabetic activities. Among all the synthesized compounds (11a-g), compound 11a exhibits excellent CDOCKER energy (-11.36 kcal/mol). The entire compounds (11a-g) confirm very good antimicrobial activity towards the tested microorganisms...
June 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28600038/potential-differentiation-of-islet-like-cells-from-pregnant-cow-derived-placental-stem-cells
#17
Shao-Yu Peng, Chien-Wen Chou, Yu-Hsuan Kuo, Perng-Chih Shen, S W Steven Shaw
OBJECTIVE: Type 1 diabetes is an autoimmune disease that destroys islet cells and results in insufficient insulin secretion by pancreatic β-cells. Islet transplantation from donors is an approach used for treating patients with diabetes; however, this therapy is difficult to implement because of the lack of donors. Nevertheless, several stem cells have the potential to differentiate from islet-like cells and enable insulin secretion for treating diabetes in animal models. For example, placenta is considered a waste material and can be harvested noninvasively during delivery without ethical or moral concerns...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28595874/evaluation-of-anti-diabetic-activity-of-glycyrrhizin-loaded-nanoparticles-in-nicotinamide-streptozotocin-induced-diabetic-rats
#18
Ruma Rani, Shakti Dahiya, Dinesh Dhingra, Neeraj Dilbaghi, Ki-Hyun Kim, Sandeep Kumar
Glycyrrhizin is an active constituent of the roots and rhizomes of Glycyrrhiza glabra and has anti-hyperglycemic effects. In this study, nanoparticles (NPs) loaded with glycyrrhizin or metformin were evaluated in vivo for their anti-hyperglycemic potency towards type-II diabetes in rats. The NPs were produced via the ionotropic gelation method using the biocompatible polymers chitosan and gum arabic. The polymer concentration was optimized using the 3(2) factorial method to acquire both minimum particle size and maximum encapsulation efficiency...
August 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28587189/roles-of-nicotinamide-adenine-dinucleotide-phosphate-nadph-oxidase-in-angiogenesis-isoform-specific-effects
#19
REVIEW
Haibo Wang, M Elizabeth Hartnett
Angiogenesis is the formation of new blood vessels from preexisting ones and is implicated in physiologic vascular development, pathologic blood vessel growth, and vascular restoration. This is in contrast to vasculogenesis, which is de novo growth of vessels from vascular precursors, or from vascular repair that occurs when circulating endothelial progenitor cells home into an area and develop into blood vessels. The objective of this review is to discuss the isoform-specific role of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) in physiologic and pathologic angiogenesis and vascular repair, but will not specifically address vasculogenesis...
June 3, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28551554/antihyperalgesic-activity-of-a-mexicanolide-isolated-from-swietenia-humilis-extract-in-nicotinamide-streptozotocin-hyperglycemic-mice
#20
Berenice Ovalle-Magallanes, Myrna Déciga-Campos, Rachel Mata
Swietenia humilis Zucc. (Meliaceae) seeds are used in Mexico for the treatment of type 2 diabetes mellitus. Mexicanolides are the main hypoglycemic and antihyperglycemic compounds of the species. This study was conducted to investigate the antihyperalgesic effect of an aqueous extract of the seeds of Swietenia humilis (SHAE) and of mexicanolide 2-hydroxy-destigloyl-6-deoxyswietenine acetate (1), using the formalin test in mice. The antihyperalgesic actions of SHAE and mexicanolide 1, as well as its possible transductional activity, were assessed in nicotinamide-streptozotocin (NA-STZ) hyperglycemic mice...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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