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lumbar degeneration

Xiaoming Liu, Fumin Pan, Zhaoyu Ba, Shanjin Wang, Desheng Wu
BACKGROUND: Diabetes mellitus (DM) and low back pain which is mainly caused by degeneration of the intervertebral discs (IVDs) both are major public health problem worldwide. The present study was designed to investigate the association between type 2 diabetes mellitus (T2D) and severity of lumbar disc degeneration (LDD). METHODS: We retrospectively reviewed patients with low back pain visiting our spine clinic in 2014. Low back pain patients all have the lumbar MRI imaging and no previous treatment...
March 14, 2018: Journal of Orthopaedic Surgery and Research
John P Kleimeyer, Ivan Cheng, Todd F Alamin, Serena S Hu, Thomas Cha, Vijay Yanamadala, Kirkham B Wood
STUDY DESIGN: This is a retrospective cohort study. OBJECTIVE: To evaluate the long-term outcomes of selective one- to two-level anterior lumbar interbody fusions (ALIFs) in the lower lumbar spine versus continued nonsurgical management. SUMMARY OF BACKGROUND DATA: Low back pain associated with lumbar intervertebral disc degeneration is common with substantial economic impact, yet treatment remains controversial. Surgical fusion has previously provided mixed results with limited durable improvement of pain and function...
March 9, 2018: Spine
Kathryn Volkening, Brian Keller, Cheryl Leysta-Lantz, Michael J Strong
Tar DNA binding protein of 43kDa (TDP-43) is a dual function RNA/DNA binding protein with varied cellular functions. In degenerating motor neurons in ALS, TDP-43 relocalizes from the nucleus to the cytosol where it is sequestered into inclusions. It is likely that the pathogenic role of TDP-43 in ALS can involve either a gain or a loss of function, depending on the nature of its RNA or protein interactor. However, while TDP-43 binding partners have been identified in a range of model systems and from the human brain, interactors from human spinal cord tissue have not...
March 7, 2018: Journal of Proteome Research
Xuanqi Xiong, Zhengwei Zhou, Matteo Figini, Junjie Shangguan, Zhuoli Zhang, Wei Chen
Objective: To quantitatively evaluate lumbar disc degeneration with recently-developed quantitative magnetic resonance imaging (MRI) techniques. A series of MRI parameters, including T2*, T1rho relaxation time, apparent diffusion coefficient and gagCEST, were compared and correlated with the Pfirrmann semi-quantitative classification of lumbar intervertebral disc degeneration; the most accurate and relevant MRI parameters of lumbar disc degeneration were identified. Materials and Methods: Thirty-seven subjects (age range, 18-74 years) with non-specific low back pain (LBP) for more than 6 months were enrolled...
2018: American Journal of Translational Research
Huihong Wu, Siting Wang, Weiyou Chen, Xinli Zhan, Zengming Xiao, Hua Jiang, Qingjun Wei
BACKGROUND: An increasing number of studies have investigated associations between collagen IX alpha 2 chain (COL9A2) and collagen IX alpha 3 chain (COL9A3) gene polymorphisms and the risk of lumbar disc degeneration (LDD). However, these studies have yielded contradictory results. The purpose of this meta-analysis is to investigate the association between the collagen IX gene polymorphisms (rs12077871, rs12722877, rs7533552 in COL9A2; rs61734651 in COL9A3) and LDD. METHODS: All relevant articles were collected from PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI)...
March 5, 2018: Journal of Orthopaedic Surgery and Research
Jia Yu, Chen Lai, Hoon Shim, Chengsong Xie, Lixin Sun, Cai-Xia Long, Jinhui Ding, Yan Li, Huaibin Cai
BACKGROUND: Dynactin p150Glued , the largest subunit of the dynactin macromolecular complex, binds to both microtubules and tubulin dimers through the N-terminal cytoskeleton-associated protein and glycine-rich (CAP-Gly) and basic domains, and serves as an anti-catastrophe factor in stabilizing microtubules in neurons. P150Glued also initiates dynein-mediated axonal retrograde transport. Multiple missense mutations at the CAP-Gly domain of p150Glued are associated with motor neuron diseases and other neurodegenerative disorders, further supporting the importance of microtubule domains (MTBDs) in p150Glued functions...
March 1, 2018: Molecular Neurodegeneration
Numan Karaarslan, Ibrahim Yilmaz, Hanefi Ozbek, Duygu Sirin Yasar, Necati Kaplan, Yener Akyuva, Aylin Gonultas, Ozkan Ates
AIM: In this scientific research project, the researchers aimed to determine the gene expression patterns of nucleus pulposus (NP) in cell cultures obtained from degenerated or intact tissues. MATERIAL AND METHODS: Whereas 12 of the cases were diagnosed with lumbar disc hernia and had undergone lumbar microdiscectomy, 12 cases had undergone traumatic intervertebral discectomy and corpectomy, along with discectomy after spinal trauma. NP-specific markers and gene expressions of the reagents of the extracellular matrix in the experimental setup were tested at the 0th, 24th, and 48th hours by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR)...
January 22, 2018: Turkish Neurosurgery
Xin Zhao, Lin Du, Youzhuan Xie, Jie Zhao
OBJECTIVE: Here we used a finite element (FE) analysis to investigate the biomechanical changes caused by transforaminal lumbar interbody fusion (TLIF) at the L4-L5 level by lumbar lordosis (LL) degree. METHODS: A lumbar FE model (L1-S5) was constructed based on computed tomography scans of a 30-year-old healthy male volunteer (pelvic incidence = 50°, LL = 52°). We investigated the influence of LL on the biomechanical behavior of the lumbar spine after TLIF in L4-L5 fusion models with 57°, 52°, 47°, and 40° LL...
February 21, 2018: World Neurosurgery
Xin Zhao, Jie Zhao, Jie Guan, Junkai Zeng, Chen Han, Yuzhou He, Tangjun Zhou, Chen Chen, Youzhuan Xie
The purpose of this study was to evaluate the relationship between the nerve root of lower lumbar and the surrounding structures using three-dimensional computed tomography (3D CT).Twenty-three consecutive patients with thoracolumbar fractures without obvious radiological degeneration were retrospectively studied at the spinal surgery department of the hospital. The parameters of the relationship between the nerve root of the lower lumbar and the surrounding structures were measured using 3D CT in the work station of the picture archiving and communication system...
February 2018: Medicine (Baltimore)
Rikke K Jensen, Peter Kent, Tue S Jensen, Per Kjaer
BACKGROUND: Research into the clinical importance of spinal MRI findings in patients with low back pain (LBP) has primarily focused on single imaging findings, such as Modic changes or disc degeneration, and found only weak associations with the presence of pain. However, numerous MRI findings almost always co-exist in the lumbar spine and are often present at more than one lumbar level. It is possible that multiple MRI findings are more strongly associated with LBP than single MRI findings...
February 20, 2018: BMC Musculoskeletal Disorders
Shingo Miyazaki, Ashish D Diwan, Kenji Kato, Kevin Cheng, Won C Bae, Yang Sun, Junichi Yamada, Carol Muehleman, Mary E Lenz, Nozomu Inoue, Robert L Sah, Mamoru Kawakami, Koichi Masuda
PURPOSE: To elucidate the effects of growth differentiation factor-6 (GDF6) on: (i) gene expression of inflammatory/pain-related molecules and structural integrity in the rabbit intervertebral disc (IVD) degeneration model, and (ii) sensory dysfunction and changes in pain-marker expression in dorsal nerve ganglia (DRGs) in the rat xenograft radiculopathy model. METHODS: Forty-six adolescent rabbits received anular-puncture in two non-consecutive lumbar IVDs. Four weeks later, phosphate-buffered saline (PBS) or GDF6 (1, 10 or 100 µg) was injected into the nucleus pulposus (NP) of punctured discs and followed for 4 weeks for gene expression analysis and 12 weeks for structural analyses...
February 19, 2018: European Spine Journal
Mehmet Hakan Seyithanoğlu, Serkan Kitiş, Ömer Faruk Özer, Abdurrahim Koçyiğit, Tolga Dündar, Meliha Gündağ Papaker, Anas Abdallah
BACKGROUND: The relationship between radiological degeneration criteria on lumbar magnetic resonance imaging (MRI) and both the keratan sulfate (KS) and chondroitin sulfate (ChS) levels was examined in disc material taken from patients undergoing lumbar disc herniation (LDH) surgery. To examine whether the biochemical and radiological degeneration criteria testing the reliability of radiological degeneration findings agreed and to evaluate the contribution of the KS/ChS ratio to disc form (protruding or extruding)...
February 6, 2018: Neurologia i Neurochirurgia Polska
Li-Guo Zhu, Ping Zhang, Qing-Hui Song, Wan-Qiang Zhang, Hong-Wei Zhu, Li-Ping Yang, Yan Zhu, Yuan Wang, Ling-Hui Li
OBJECTIVE: To study the effect of Bushen Huoxue decoction on calcification of cartilage endplate in lumbar vertebrae. METHODS: Six healthy male gerbils with 2-month-old were selected as normal control group, and 24 7-month-old healthy male gerbils were fed to 12-month-old to establish the aged gerbil model. Thirty gerbils were randomly divided into five groups as follow: the normal control group ( n =6), model group ( n =6, normal saline 4 ml/kg, intragastric 30 d), Bushen Huoxue low dose group( n =6, 1...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Nikunj N Trivedi, Sean M Wilson, Luis A Puchi, Darren R Lebl
Study Design: Narrative review. Objectives: The etiology of adjacent segment degeneration (ASDeg) and adjacent segment disease (ASDz) after lumbar interbody fusion (LIF) remains controversial. The aim of this narrative review was to provide an evidence-based analysis of the peer-reviewed literature on clinical studies of ASDeg and ASDz after LIF. Methods: A review was performed utilizing Medline, Embase, and Cochrane databases. Two reviewers independently extracted relevant data from each included study...
February 2018: Global Spine Journal
John T Martin, Alexander B Oldweiler, Charles E Spritzer, Brian J Soher, Melissa M Erickson, Adam P Goode, Louis E DeFrate
Low back pain is a significant socioeconomic burden in the United States and lumbar intervertebral disc degeneration is frequently implicated as a cause. The discs play an important mechanical role in the spine, yet the relationship between disc function and back pain is poorly defined. The objective of this work was to develop a technique using magnetic resonance imaging (MRI) and three-dimensional modeling to measure in vivo disc deformations. Using this method, we found that disc geometry was measurable with precision less than the in-plane dimensions of a voxel (≈100 µm, 10% of the MRI pixel size)...
February 9, 2018: Journal of Biomechanics
Jian-Hua Tang, Li-Li Zhao, Chun-Ming Huang, Cheng-Fan Zhong, Xiao-Chuan Li, Yu-Sheng He
OBJECTIVE: To explore the method and clinical effect of MAST Quadrant for lumbar spondylolisthesis with adjacent segment degeneration. METHODS: From April 2014 to January 2016, 36 cases of lumbar spondylolisthesis with adjacent segment degeneration were treated by MAST Quadrant(target nerve decompression and transforaminal lumbar interbody fusion or articulationes zygapophysiales fusion by unilateral fixation with MAST Quadrant). Twenty-three cases were degenerative lumbar spondylolisthesis and 13 cases were isthmic lumbar spondylolisthesis...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Yang Luo, Shu-Yang Li, Fa-Ming Tian, Hui-Ping Song, Ying-Ze Zhang, Liu Zhang
PURPOSE: Lumbar intervertebral disc degeneration is a common cause of lower back pain that affects the physical and mental health of patients and increases social burden. Parathyroid hormone has been reported to be effective at inhibiting disc degeneration; however, these effects have not been fully established in vivo in ovariectomized (OVX) rats. Thus, in this study, we aimed to address this issue and examine the effects of parathyroid hormone treatment in OVX rats. METHODS: Thirty female Sprague-Dawley rats, three months-old, were subjected to sham or ovariectomy surgery...
February 13, 2018: International Orthopaedics
Xianda Gao, Linfeng Wang, Changzhi Yan, Yanlong Gao, Yong Shen
BACKGROUND The aim of this study was to identify the predictors of deterioration in sagittal balance in patients with adult scoliosis following long fusion arthrodesis to L5. MATERIAL AND METHODS A retrospective clinical study included 63 patients with adult scoliosis who underwent long fusion arthrodesis to L5, between February 2005 and May 2015. Radiological imaging values included the angle of lumbar lordosis (LL), and the angle of pelvic incidence (PI). The patients were divided into two cohorts, according to the threshold of average loss of sagittal vertical axis (SVA): a cohort with stable sagittal balance (SSB) and a cohort with deteriorated sagittal balance (DSB)...
February 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jinyue He, Chencheng Feng, Jing Sun, Kang Lu, Tongwei Chu, Yue Zhou, Yong Pan
Lumbar disc disease (LDD) is common in aged populations, and it is primarily caused by intervertebral disc degeneration (IDD). Cartilage intermediate layer protein (CILP), which is specifically expressed in intervertebral discs (IVDs), is suspected to be associated with IDD. However, it remains unclear whether CILP contributes to IDD in humans. Furthermore, the regulation of CILP in human IVDs is poorly understood, especially by mechanical stimuli, which are regarded as primary factors promoting IDD. To address these issues, the present study collected nucleus pulposus (NP) cells from patients undergoing lumbar spinal surgery for degenerative disc disease (DDD)...
February 12, 2018: Molecular Medicine Reports
Yang-Jun Lao, Tao-Tao Xu, Hong-Ting Jin, Hong-Feng Ruan, Ji-Tao Wang, Li Zhou, Ping-Er Wang, Jian Wang, Jun Ying, Yuan-Bin Zhang, Cheng Luo, Fang-da Fu, Pei-Jian Tong, Lu-Wei Xiao, Cheng-Liang Wu
OBJECTIVE: To investigate the effect of accumulated spinal axial biomechanical loading on mice lumbar disc and the feasibility of applying this method to establish a mice intervertebral disc degeneration model using a custom-made hot plate cage. In previous studies, we observed that the motion pattern of mice was greatly similar to that of humans when they were standing and jumping on their lower limbs. There is little data to demonstrate whether or not accumulated spinal axial biomechanical loading could induce intervertebral disc degeneration in vivo...
February 12, 2018: Orthopaedic Surgery
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