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https://www.readbyqxmd.com/read/29774557/diabetes-induced-microvascular-complications-at-the-level-of-the-spinal-cord-a-contributing-factor-in-diabetic-neuropathic-pain
#1
N Ved, M E Da Vitoria Lobo, S M Bestall, C L Vidueira, N Beazley-Long, K Ballmer-Hofer, M Hirashima, D O Bates, L F Donaldson, R P Hulse
Abnormalities of neurovascular interactions within the central nervous system of diabetic patients is associated with the onset of many neurological disease states. However, to date, the link between the neurovascular network within the spinal cord and regulation of nociception has not been investigated despite neuropathic pain being common in diabetes. We hypothesised that hyperglycaemia-induced endothelial degeneration in the spinal cord, due to suppression of VEGF-A/VEGFR2 signalling, induces diabetic neuropathic pain...
May 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29772868/-significance-of-cell-autophagy-in-resorption-of-lumbar-disc-herniation
#2
REVIEW
Zhi-Jun Diao, Hong Jiang, Jin-Tao Liu
As a self-protective mechanism of cells, autophagy of cells can maintain cell stability by degrading self-aging substances, and it can be highly induced. The ability of autophagy to degraded cells will decrease with age. The resorption phenomenon after lumbar disc herniation is one of the effective mechanisms in conservative treatment of lumbar disc herniation. The degenerative lesion of intervertebral disc is one of the main reasons of lumbar disc herniation. Cell autophagy is extensive participation in the degeneration of lumbar intervertebral disc, delaying the occurrence of degenerative disease...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29772864/-analysis-of-delayed-infection-of-proximal-junctional-zone-after-posterior-spinal-internal-fixation-and-its-treatment-strategy
#3
Gong-Qun Jiang, Yong-Heng Liu, De-Yuan Chen, Yong-Ai Liu
OBJECTIVE: To explore the features and treatment strategy of delayed infection of proximal junctional zone after posterior spinal internal fixation. METHODS: The clinical data of 1325 patients underwent posterior spinal internal fixation were retrospectively analyzed. Delayed infection occurred in 10 patients, among which 4 infections occurred at the proximal junction (non-operative site). And these 4 patients were treated with combined broad-spectrum antibiotics...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29772861/-analysis-of-clinical-effects-in-the-treatment-of-single-segment-lumbar-degenerative-disease-by-lamina-osteotomy-and-former-vertebral-plates-regraft
#4
Da-Peng Duan, Zhi-Long Chen, Hong-Hai Xu, Zong-Zhi Liu
OBJECTIVE: To compare the clinical effect between the lamina osteotomy and former vertebral plates regraft method and total laminectomy and interbody fusion method in treating single-segment lumbar degenerative disease. METHODS: The clinical data of 167 patients with single-segment lumbar degenerative disease underwent surgical treatment from January 2010 to December 2014 were retrospectively analyzed. There were 92 males and 75 females, aged from 45 to 75 years old with an average of (59...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29772368/volumetric-muscle-measurements-indicate-significant-muscle-degeneration-in-single-level-disc-herniation-patients
#5
Kaan Yaltırık, Burhan Oral Güdü, Yüksel Işık, Çiğdem Altunok, Ufuk Tipi, Başar Atalay
INTRODUCTION: There is a strong relationship between lower back pain and paraspinal muscle atrophy. In this study, we aimed to investigate the prevalence of lumbar paravertebral muscle atrophy in patients with and without single level disc herniation. MATERIALS AND METHODS: The 110 retrospectively analyzed patients in this study were divided into two groups. Group A included 55 patients with radiologically confirmed single level disc herniation with back pain and radiculopathy...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29770581/effect-of-static-compression-loads-on-intervertebral-disc-an-in-vivo-bent-rat-tail-model
#6
Wei Xia, Lin-Lin Zhang, Jun Mo, Wen Zhang, Hai-Tao Li, Zong-Ping Luo, Hui-Lin Yang
OBJECTIVE: To evaluate how well different magnitudes of compression-induced degenerative changes using a bent rat tail model simulated human lumbar lordosis. It has been shown that compression plays an important role in intervertebral disc degeneration (IDD). METHODS: Sprague-Dawley rats (n = 25) were instrumented with a special compressive apparatus that was used to bend the intervertebral disc between the 8th and the 10th caudal vertebral bodies using two Kirschner wires inserted percutaneously into the middle of two tail vertebrae...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29770178/dynamic-stabilization-for-degenerative-diseases-in-the-lumbar-spine-2-years-results
#7
Ahmed Hosny Khalifa, Timo Stübig, Oliver Meier, Christian Walter Müller
Following lumbar fusion, adjacent segment degeneration has been frequently reported. Dynamic systems are believed to reduce main fusion drawbacks. We conducted a retrospective study on patients with degenerative lumbar disease treated with posterior dynamic stabilization with monoaxial hinged pedicular screws and lumbar decompression. VAS and ODI were used to compare clinical outcomes. As radiological outcomes, LL and SVA were used. 51 patients were included with an average follow-up of 24 months. 13 patients were revised because of postoperative radiculopathy (n=4), subcutaneous hematoma (n=2), L5 screw malposition (n=1) and adjacent segment disease (n=6)...
March 29, 2018: Orthopedic Reviews
https://www.readbyqxmd.com/read/29763470/the-influence-of-spinal-pelvic-parameters-on-the-prevalence-of-endplate-modic-changes-in-degenerative-thoracolumbar-lumbar-kyphosis-patients
#8
Weiwei Xia, Chenjun Liu, Shuo Duan, Shuai Xu, Kaifeng Wang, Zhenqi Zhu, Haiying Liu
BACKGROUND: The typical degeneration of the vertebral endplate shown in MRI imaging is Modic change. The aim of this study was to observe the distribution of the Modic changes of vertebral endplate in degenerative thoracolumbar/lumbar kyphosis (DTK/LK) patients and analyse the correlation between spinal-pelvic parameters and Modic changes. METHODS: The imaging data of 58 patients diagnosed with DTK/LK (coronal Cobb angle<10°with sagittal imbalance) in our hospital from March 2016 to May 2017 were reviewed retrospectively...
2018: PloS One
https://www.readbyqxmd.com/read/29759081/comparative-study-of-the-paraspinal-muscles-after-ovf-between-the-insufficient-union-and-sufficient-union-using-mri
#9
Marina Katsu, Tetsuro Ohba, Shigeto Ebata, Hirotaka Haro
BACKGROUND: Identification of poor prognostic factors for OVF is important but has not yet been clearly established. Despite paraspinal muscles could play an important role in the etiology of OVF, what influence time-dependent changes in paraspinal muscles have after OVF, and the impact on conservative treatments for patients who have an OVF remain largely unknown. The purposes of this study were to (1) evaluate time-dependent changes of the paraspinal musculature using MRI after injury in patients with osteoporotic vertebral fractures (OVFs), and (2) compare paraspinal muscles between conservatively treated patients with OVF who have successful union and those failed to conservative treatment...
May 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29758454/biomechanical-investigation-on-the-influence-of-the-regional-material-degeneration-of-an-intervertebral-disc-in-a-lower-lumbar-spinal-unit-a-finite-element-study
#10
Masni-Azian, Masao Tanaka
Intervertebral disc degeneration involves changes in its material properties that affect the mechanical functions of the spinal system. However, the alteration of the biomechanics of a spinal segment through specific material degradation in a specific region is poorly understood. In this study, the influence of the constitutive material degeneration of disc tissues on the mechanics of a lower lumbar spinal unit was examined using a three-dimensional nonlinear finite element model of the L4-L5 functional spinal unit...
May 6, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29758372/percutaneous-endoscopic-lumbar-surgery-via-transfacet-approach-for-lumbar-synovial-cyst
#11
Hsuan-Han Wu, Lei Chu, Yong-Jian Zhu, Chun-Yuan Cheng, Chien-Min Chen
BACKGROUND: There are currently no high-quality studies on the optimal therapeutic approach for juxtafacet cyst as treatment guidelines have not been developed. Herein, a novel technique in which using an endoscopic transfacet approach to treat a patient with symptomatic lumbar synovial cyst was presented. . CASE DESCRIPTION: A 87-year-old man presented with severe dull pain in the right anterior thigh had developed. Lumbar magnetic resonance imaging (MRI) revealed disc extrusion over the central canal zone at the L2-3 and L4-L5 level, and an ovoid lesion with a hyperintense center plus a hypointense rim on the T2-weighted image...
May 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29753167/the-frequency-of-re-surgery-after-lumbar-disc-nucleoplasty-in-a-ten-year-period
#12
Stephan Klessinger
OBJECTIVE: Percutaneous disc nucleoplasty (PDN) is a minimally invasive technique. A portion of the nucleus tissue is ablated using the Coblation technique. Re-surgery is an important factor for the clinical outcome. However, the rate of subsequent surgery after PDN is still unknown. The aim of the present study was to investigate the frequency of an additional open surgery after PDN in a retrospective of more than ten years. PATIENTS AND METHODS: Retrospective observational study...
May 5, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29750755/predicting-factors-at-skeletal-maturity-for-curve-progression-and-low-back-pain-in-adult-patients-treated-non-operatively-for-adolescent-idiopathic-scoliosis-with-thoracolumbar-lumbar-curves-a-mean-25-year-follow-up
#13
Masayuki Ohashi, Kei Watanabe, Toru Hirano, Kazuhiro Hasegawa, Keiichi Katsumi, Hirokazu Shoji, Mizouchi Tatsuki, Naoto Endo
STUDY DESIGN: A retrospective, long-term follow-up study. OBJECTIVE: We aimed to clarify the predicting factors at skeletal maturity for future curve progression and low back pain (LBP) in adolescent idiopathic scoliosis (AIS) with thoracolumbar/lumbar (TL/L) curve. SUMMARY OF BACKGROUND DATA: TL/L curves are likely to progress after skeletal maturity and cause LBP. METHODS: Of 147 patients treated non-operatively for AIS with TL/L curve, 56 (55 females; average age at the time of survey, 39...
May 10, 2018: Spine
https://www.readbyqxmd.com/read/29748528/salmon-calcitonin-attenuates-degenerative-changes-in-cartilage-and-subchondral-bone-in-lumbar-facet-joint-in-an-experimental-rat-model
#14
Yu Gou, Faming Tian, Qingfu Kong, Tiangang Chen, Hetong Li, Qinglie Lv, Liu Zhang
BACKGROUND Facet joint degeneration (FJD) is one of the common causes of low back pain (LBP), and estrogen deficiency is one of the triggers for FJD. Calcitonin may possess the potential for treating osteoarthritis, but to date the hormone has not been studied in the treatment of FJD. Therefore, the aim of this study was to investigate the effects of salmon calcitonin (sCT) on FJD induced by estrogen deficiency after ovariectomy (OVX). MATERIAL AND METHODS Thirty female Sprague-Dawley rats were randomly assigned to 3 groups: the OVX group received bilateral OVX, the OVX + sCT group received subcutaneous administration of sCT (16 IU/kg/2 days) following bilateral OVX, and the Sham group received sham surgery...
May 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29748204/a-qualitative-and-quantitative-correlation-study-of-lumbar-intervertebral-disc-degeneration-using-glycosaminoglycan-chemical-exchange-saturation-transfer-pfirrmann-grade-and-t1-%C3%AF
#15
O Togao, A Hiwatashi, T Wada, K Yamashita, K Kikuchi, C Tokunaga, J Keupp, M Yoneyama, H Honda
BACKGROUND AND PURPOSE: Glycosaminoglycan chemical exchange saturation transfer (gagCEST) imaging allows the direct measurement and mapping of glycosaminoglycans. In this study, we aimed to evaluate the usefulness of gagCEST imaging in the quantitative assessment of intervertebral disc degeneration in a comparison with Pfirrmann grade and T1-ρ measurements. MATERIALS AND METHODS: Ninety-six lumbar intervertebral discs in 24 volunteers (36.0 ± 8.5 years of age, 21 men and 3 women) were examined with both gagCEST imaging and T1-ρ measurements...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29744650/a-novel-in-vivo-porcine-model-of-intervertebral-disc-degeneration-induced-by-cryoinjury
#16
Charles-Henri Flouzat-Lachaniette, Nicolas Jullien, Charlie Bouthors, Eric Beohou, Béatrice Laurent, Philippe Bierling, Arnaud Dubory, Hélène Rouard
PURPOSE: Degenerative disc disease involves sequential events that lead to the loss of cells, a decrease in disc matrix production, disc dehydration, and alteration of its biomechanical properties. The aim of this study was to determine whether cryoinjury of the nucleus pulposus performed through endplate perforation contributes to disc degeneration and to compare this technique with standard methods. METHOD: Under general anesthesia, the lumbar discs of six pigs were exposed and randomly submitted to needle puncture of the annulus fibrosus (NeP), isolated endplate injury (EP), or cryoinjury using a 2...
May 10, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29736782/exercise-attenuates-age-associated-changes-in-motoneuron-number-nucleocytoplasmic-transport-proteins-and-neuromuscular-health
#17
Ashley Gillon, Kathrine Nielsen, Charlotte Steel, Jon Cornwall, Philip Sheard
Life expectancy continues to extend, although frailty caused by loss of skeletal muscle mass continues unimpeded. Muscle atrophy caused by withdrawal of motor nerves is a feature of old age, as it is in amyotrophic lateral sclerosis (ALS) in which skeletal muscle denervation results from motoneuron death. In ALS, direct links have been established between motoneuron death and altered nucleocytoplasmic transport, so we ask whether similar defects accompany motoneuron death in normal ageing. We used immunohistochemistry on mouse tissues to explore potential links between neuromuscular junction (NMJ) degeneration, motoneuron death and nucleocytoplasmic transport regulatory proteins...
May 7, 2018: GeroScience
https://www.readbyqxmd.com/read/29736202/effects-of-aav2-mediated-co-transfection-of-ctgf-and-timp1-genes-on-degenerative-lumbar-intervertebral-discs-in-rhesus-monkeys-in-vivo
#18
Yong Liu, Jie Kong, Yong-Ming Xi, Tao Yu, Xiao-Lin Wu, You-Gu Hu
OBJECTIVE: This study aims to investigate the effects of co-transfection of the genes for connective tissue growth factor (CTGF) and tissue inhibitor of metalloproteinase-1 (TIMP1) mediated by adeno-associated virus 2 (AAV2) on degenerative lumbar intervertebral discs in a primate model. METHODS: Twelve 4-7 year-old rhesus monkeys weighing 4.5-7.0 kg were utilized. CTGF and TIMP1 genes carried by AAV2 were injected into the degenerative lumbar intervertebral discs...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29734212/time-course-of-radiologic-changes-after-lumbar-total-disc-replacement-experience-of-single-institute-with-minimum-5-year-follow-up
#19
Jung-Woo Hur, Jin-Sung Kim, Kyeong-Sik Ryu, Myeong-Hoon Shin, Chun-Kun Park
STUDY DESIGN: This was a retrospective observatory analysis study. OBJECTIVE: The purpose of this study was to evaluate long-term safety and therapeutic effectiveness of the lumbar total disc replacement (TDR) using ProDisc-L by analyzing the radiologic changes at the index and adjacent levels in minimum 5-year follow-up. SUMMARY OF BACKGROUND DATA: Early successful clinical results of lumbar TDR have been reported. However, few reports have published its therapeutic effectiveness and radiologic degenerative changes at the index and adjacent segments in the long term...
May 4, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29732581/discrete-mitochondrial-aberrations-in-the-spinal-cord-of-sporadic-als-patients
#20
Vedad Delic, Crupa Kurien, Josean Cruz, Sandra Zivkovic, Jennifer Barretta, Avery Thomson, Daniel Hennessey, Jaheem Joseph, Jared Ehrhart, Alison E Willing, Patrick Bradshaw, Svitlana Garbuzova-Davis
Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease characterized by progressive motor neuron degeneration in the brain and spinal cord leading to muscle atrophy, paralysis, and death. Mitochondrial dysfunction is a major contributor to motor neuron degeneration associated with ALS progression. Mitochondrial abnormalities have been determined in spinal cords of animal disease models and ALS patients. However, molecular mechanisms leading to mitochondrial dysfunction in sporadic ALS (sALS) patients remain unclear...
May 6, 2018: Journal of Neuroscience Research
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