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lumbar degeneration

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https://www.readbyqxmd.com/read/28221177/semirigid-waved-rod-system-for-the-treatment-of-the-degenerative-lumbar-diseases
#1
Lei Wang, Dasheng Lin, Weitao Zou, Hui Liu, Kejian Lian
BACKGROUND: The semirigid pedicle screw instrumentation has gained wide popularity in recent decennium in lumbar fusion surgery. However, few data were documented to compare the clinical efficacy between semirigid and traditional rigid pedicle screw systems. MATERIALS AND METHODS: A total of 96 patients with degenerative lumbar diseases were selected to perform operations between 2008 and 2013. The patients were prospectively randomized into 2 groups: 50 patients were managed by semirigid waved rod systems and 46 patients were intervened by traditional rigid straight stiff rod systems...
February 17, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28219354/relationship-between-facet-tropism-and-facet-joint-degeneration-in-the-sub-axial-cervical-spine
#2
Xin Rong, Ziyang Liu, Beiyu Wang, Xuelin Pan, Hao Liu
BACKGROUND: Facet tropism is the angular asymmetry between the left and right facet joint orientation. Although debatable, facet tropism was suggested to be associated with disc degeneration, facet degeneration and degenerative spondylolisthesis in the lumbar spine. The purpose of this study was to explore the relationship between facet tropism and facet degeneration in the sub-axial cervical spine. METHODS: A total of 200 patients with cervical spondylosis were retrospectively analyzed...
February 20, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28216287/association-between-measures-of-vertebral-endplate-morphology-and-lumbar-intervertebral-disc-degeneration
#3
Semra Duran, Mehtap Cavusoglu, Hatice Gul Hatipoglu, Deniz Sozmen Cılız, Bulent Sakman
PURPOSE: The aim of this study was to evaluate the association between vertebral endplate morphology and the degree of lumbar intervertebral disc degeneration via magnetic resonance imaging (MRI). METHODS: In total, 150 patients who met the inclusion criteria and were 20-60 years of age were retrospectively evaluated. Patients were evaluated for the presence of intervertebral disc degeneration or herniation, and the degree of degeneration was assessed at all lumbar levels...
February 16, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28210985/lumbar-disc-degeneration-was-not-related-to-spine-and-hip-bone-mineral-densities-in-chinese-facet-joint-osteoarthritis-may-confound-the-association
#4
Jianjiang Pan, Xuan Lu, Ge Yang, Yongmei Han, Xiang Tong, Yue Wang
: A sample of 512 Chinese was studied and we observed that greater disc degeneration on MRI was associated with greater spine DXA BMD. Yet, this association may be confounded by facet joint osteoarthritis. BMD may not be a risk factor for lumbar disc degeneration in Chinese. PURPOSE: Evidence suggested that lumbar vertebral bone and intervertebral disc interact with each other in multiple ways. The current paper aims to determine the association between bone mineral density (BMD) and lumbar disc degeneration using a sample of Chinese...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28207788/self-complementary-adeno-associated-virus-serotype-6-mediated-knockdown-of-adamts4-induces-long-term-and-effective-enhancement-of-aggrecan-in-degenerative-human-nucleus-pulposus-cells-a-new-therapeutic-approach-for-intervertebral-disc-disorders
#5
Demissew Shenegelegn Mern, Anja Tschugg, Sebastian Hartmann, Claudius Thomé
Inhibition of intervertebral disc (IVD) degeneration, which is often accompanied by painful inflammatory and immunopathological processes, is challenging. Current IVD gene therapeutic approaches are based on adenoviral gene delivery systems, which are limited by immune reactions to their viral proteins. Their applications in IVDs near to sensitive neural structure could provoke toxicity and immunological side-effects with neurological deficits. Self-complementary adeno-associated virus (scAAV) vectors, which do not express any viral gene and are not linked with any known disease in humans, are attractive therapeutic gene delivery vectors in degenerative IVDs...
2017: PloS One
https://www.readbyqxmd.com/read/28207762/minimally-invasive-procedure-reduces-adjacent-segment-degeneration-and-disease-new-benefit-based-global-meta-analysis
#6
Xiao-Chuan Li, Chun-Ming Huang, Cheng-Fan Zhong, Rong-Wei Liang, Shao-Jian Luo
OBJECTIVE: Adjacent segment pathology (ASP) is a common complication presenting in patients with axial pain and dysfunction, requiring treatment or follow-up surgery. However, whether minimally invasive surgery (MIS), including MIS transforaminal / posterior lumbar interbody fusion (MIS-TLIF/PLIF) decreases the incidence rate of ASP remains unknown. The aim of this meta-analysis was to compare the incidence rate of ASP in patients undergoing MIS versus open procedures. METHODS: This systematic review was undertaken by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement...
2017: PloS One
https://www.readbyqxmd.com/read/28193137/risk-factors-for-adjacent-segment-degeneration-after-iliac-screw-fixation-in-lumbar-degenerative-kyphoscoliosis
#7
Sang-Il Kim, Kee-Yong Ha, Dong-Whan Suh, In-Soo Oh
PURPOSE: To analyze pre- and postoperative spinopelvic parameters and sagittal profiles in lumbar degenerative kyphoscoliosis (LDK) patients who underwent surgery using iliac screw (IS) and the incidence and risk factor of radiological adjacent segment degeneration (ASD). METHODS: A total of 32 patients, who had undergone surgical correction and lumbar/thoracolumbar fusion with pedicle screws and IS instrumentation for LDK with a minimum 2-year follow-up, were included...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28185980/a-new-quantitative-measure-of-disc-degeneration
#8
Tapio Videman, Michele C Battié, Laura E Gibbons, Kevin Gill
BACKGROUND CONTEXT: The ability to adequately measure a phenomenon is critical to studying and understanding it. Since 1957, a variety of subjective visual grading methods have been used to assess disc degeneration, but have been limited by gross ordinal scales and imprecision, as well as suboptimal reliability. Conceptually sound, objective, precise measurements are needed to advance knowledge of disc degeneration and its causes, progression and consequences. PURPOSE: To investigate the reliability and validity of a new system ('SpIn' for Spine Insight) to quantitatively measure lumbar disc degeneration or pathology...
February 6, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28185063/osteochondral-loose-body-an-unusual-cause-of-lumbar-spinal-stenosis
#9
Katrina Treon, M Ockendon
Lumbar spinal stenosis is most often a degenerate condition observed in the older population. We describe the case of a lady with typical claudicant symptoms with an unusual cause of stenosis identified at the time of her decompressive surgery. On review of the literature this is only the second case of osteochondral loose body as a cause for lumbar spinal stenosis and thus remains a rare phenomenon.
February 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28173745/characterization-of-chronic-axonal-degeneration-using-diffusion-tensor-imaging-in-canine-spinal-cord-injury-a-quantitative-analysis-of-dti-parameters-according-to-histopathological-differences
#10
Hakyoung Yoon, Jaehwan Kim, Won-Jin Moon, Sang-Soep Nahm, Jun Zhao, Hyoung-Moon Kim, Kidong Eom
Diffusion tensor imaging (DTI) is more sensitive than conventional magnetic resonance imaging (MRI) for the identification of axonal degeneration. However, no study to date has used DTI to evaluate the severity of axonal degeneration in canine spinal cord injury. Therefore, the aim of this study was to characterize multi-grade axonal degeneration (mild, moderate, and severe) in a canine model of spinal cord compression injury using DTI. MRI data were obtained from six normal dogs and five dogs with lumbar spinal cord injury 78 days after spinal cord injury (L1-L3) using a 3T MRI scanner...
February 7, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28168343/is-infection-the-possible-initiator-of-disc-disease-an-insight-from-proteomic-analysis
#11
S Rajasekaran, Chitraa Tangavel, Siddharth N Aiyer, Sharon Miracle Nayagam, M Raveendran, Naveen Luke Demonte, Pramela Subbaiah, Rishi Kanna, Ajoy Prasad Shetty, K Dharmalingam
STUDY DESIGN: Proteomic and 16S rDNA analysis of disc tissues obtained in vivo. OBJECTIVE: To address the controversy of infection as an aetiology for disc disorders through protein profiling. There is raging controversy over the presence of bacteria in human lumbar discs in vivo, and if they represent contamination or infection. Proteomics can provide valuable insight by identifying proteins signifying bacterial presence and, also host defence response proteins (HDRPs), which will confirm infection...
February 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28152249/feasibility-study-for-evaluating-early-lumbar-facet-joint-degeneration-using-axial-t1-%C3%AF-t2-and-t2-mapping-in-cartilage
#12
Jianzhong Hu, Yi Zhang, Chunyue Duan, Xianjing Peng, Ping Hu, Hongbin Lu
PURPOSE: To assess the feasibility of axial T2 , T2*, and T1 ρ mapping of lumbar facet joint (LFJ) cartilage for evaluation of early degeneration. MATERIALS AND METHODS: We examined a total of 176 LFJs from 21 volunteers using axial T2 , T2*, and T1 ρ mapping with a 3.0T magnetic resonance imaging (MRI) scanner. All LFJs were measured and grouped according to the presence of low back pain (LBP), the Weishaupt grading system, and the Pfirrmann grade of the adjacent intervertebral disk (IVD)...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28151909/incidence-and-risk-factors-of-adjacent-segment-disease-following-posterior-decompression-and-instrumented-fusion-for-degenerative-lumbar-disorders
#13
Hui Wang, Lei Ma, Dalong Yang, Tao Wang, Sen Liu, Sidong Yang, Wenyuan Ding
The purpose of this study was to explore incidence and risk factors of adjacent segment disease (ASD) following posterior decompression and instrumented fusion for degenerative lumbar disorders, and hope to provide references in decision making and surgical planning for both spinal surgeon and surgically treated patients.By retrieving the medical records from January 2011 to December 2013 in our hospital, 237 patients were retrospectively reviewed. According to the occurrence of ASD at follow up, patients were divided into 2 groups: ASD and N-ASD group...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28144734/rehydration-of-a-degenerated-disc-on-mri-synchronized-with-transition-of-modic-changes-following-stand-alone-xlif
#14
Kenichiro Kita, Toshinori Sakai, Mitsunobu Abe, Yoichiro Takata, Koichi Sairyo
Lumbar intervertebral disc degeneration (LDD) is known to be associated with low back pain (LBP) and leads to degenerative lumbar disease. LDD is considered to be irreversible, and no truly effective treatment that suppresses LDD or regenerates the degenerated disc has been established thus far. Here, we report the case of a 42-year-old woman with a 10-year history of persistent LBP. Magnetic resonance imaging (MRI) demonstrated degenerative changes (Pfirrmann classification: grade IV) in the L4-5 intervertebral disc with type I and III mixed Modic changes adjacent to the disc...
January 31, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28143455/the-association-of-lumbar-curve-magnitude-and-spinal-range-of-motion-in-adolescent-idiopathic-scoliosis-a-cross-sectional-study
#15
Kamil Eyvazov, Dino Samartzis, Jason Pui Yin Cheung
BACKGROUND: Spinal deformities affect the overall alignment of the spine and thus the vectors of loading on the lumbar region and intervertebral discs. Due to wedging of the disc or vertebrae of unbalanced spinal segments, alignment change may affect the range of motion (ROM) of individual spinal segments or the global spine. This is particularly important in adolescent idiopathic scoliosis (AIS) patients who may suffer from early degeneration, back stiffness and pain. Hence, this study aimed to determine the correlation between spine range of motion (ROM) and adolescent idiopathic scoliosis (AIS) curve magnitude...
January 31, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28128704/cervical-lordotic-alignment-following-posterior-spinal-fusion-for-adolescent-idiopathic-scoliosis-reciprocal-changes-and-risk-factors-for-malalignment
#16
Kazunori Hayashi, Hiromitsu Toyoda, Hidetomi Terai, Akinobu Suzuki, Masatoshi Hoshino, Koji Tamai, Shoichiro Ohyama, Hiroaki Nakamura
OBJECTIVE Numerous reports have been published on the effectiveness and safety of correction of the coronal Cobb angle and thoracolumbar sagittal alignment in patients with adolescent idiopathic scoliosis (AIS). Suboptimal sagittal alignment, such as decreased thoracic kyphosis (TK), after corrective surgery, is a possible cause of lumbar or cervical spinal degeneration and junctional malalignment; however, few reports are available on reciprocal changes outside of the fused segments, such as the cervical lordotic angle (CLA)...
January 27, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28128448/chronic-infusion-of-sod1-g93a-astrocyte-secreted-factors-induces-spinal-motoneuron-degeneration-and-neuromuscular-dysfunction-in-healthy-rats
#17
U N Ramírez-Jarquín, F Rojas, B van Zundert, R Tapia
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease and studies in vitro show that motoneuron degeneration is triggered by non-cell-autonomous mechanisms. However, whether soluble toxic factor(s) released by mutant superoxide dismutase 1 (SOD1) expressing astrocytes induces death of motoneurons and leads to motor dysfunction in vivo is not known. To directly test this, healthy adult rats were treated with conditioned media derived from primary mouse astrocytes (ACM) that express human (h) SOD1(G93A) (ACM-hG93A) via chronic osmotic pump infusion in the lumbar spinal cord...
January 27, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28128000/assessment-and-rehabilitation-of-chronic-low-back-pain-in-baseball-part-ii
#18
Joseph G Wasser, Jason L Zaremski, Daniel C Herman, Heather K Vincent
Repetitive throwing and hitting motions in baseball place mechanical stresses to the lumbar spine which may cause low back pain (LBP). Pain may be due to vertebral stress reactions or insufficiency fractures, intervertebral disc degeneration or intervertebral disc herniation. Untreated chronic conditions have high potential to lead to a more significant injury such as spondylolysis. Chronic LBP increases the risk for missed playing time, early career termination and lower quality of life after retirement. Proper clinical assessment and prevention/rehabilitation of LBP in this population is thus important for performance, play time and overall long-term quality of life...
January 27, 2017: Research in Sports Medicine
https://www.readbyqxmd.com/read/28127375/predictors-of-reoperation-after-microdecompression-in-lumbar-spinal-stenosis
#19
Hee-Jong Hwang, Hyung-Ki Park, Gwang-Soo Lee, June-Young Heo, Jae-Chil Chang
OBJECTIVE: The risk factors of reoperation after microdecompression (MD) for lumbar spinal stenosis (LSS) are unclear. In this study, we presented the outcomes of MD for degenerative LSS and investigated the risk factors associated with reoperation. METHODS: A retrospective review was conducted using the clinical records and radiographs of patients with LSS who underwent MD. For clinical evaluation, we used the Japanese Orthopedic Association (JOA) scoring system for low back pain, body mass index, and Charlson comorbidity index...
December 2016: Korean Journal of Spine
https://www.readbyqxmd.com/read/28124176/charcot-spinal-arthropathy-in-patients-with-congenital-insensitivity-to-pain-a-report-of-two-cases-and-review-of-the-literature
#20
REVIEW
Michael D Staudt, Christopher S Bailey, Fawaz Siddiqi
Charcot spine, or neuropathic spinal arthropathy, involves the progressive destruction of the spinal joint due to the lack of normal protective sensations and proprioception. A rare cause of Charcot spine is congenital insensitivity to pain, which is an absent or abnormal response to painful stimuli. There are few case reports describing this condition, and long-term follow-up data are limited. The presentation and treatment of two patients with Charcot spine secondary to congenital insensitivity to pain are described...
January 26, 2017: Neurosurgical Review
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