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https://www.readbyqxmd.com/read/28735484/microsphere-based-assessment-of-dna-methylation-for-aml-prognosis
#1
Gerald B W Wertheim, Marlise R Luskin, Martin Carroll, Stephen R Master
Epigenetic dysregulation, including aberrant methylation of cytosine residues in DNA, is a hallmark of cancer and clearly results in oncogenic cellular alterations such as transcriptional attenuation of tumor suppressors and genomic instability. A number of studies have examined DNA methylation alterations in patients with acute myeloid leukemia (AML) and have shown that analysis of multilocus methylation patterns can identify biologically distinct AML subclasses and can predict patient prognosis. In order to utilize the prognostic capability of methylation analysis in a clinical setting, we have developed a microsphere-based HpaII tiny fragment enrichment by ligation-mediated PCR (xMELP) assay to interrogate the methylation state of genomic multiple loci along with a random forest-based classification algorithm that correlates DNA methylation status with patient prognosis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28735465/approximal-morphology-as-predictor-of-approximal-caries-in-primary-molar-teeth
#2
A Cortes, S Martignon, V Qvist, Kim Rud Ekstrand
OBJECTIVE: To evaluate the predictive power of the morphology of the distal surface on 1st and mesial surface on 2nd primary molar teeth on caries development in young children. SAMPLE AND METHODS: Out of 101 3-to 4-year-old children from an on-going study, 62 children, for whom parents' informed consent was given, participated. Upper and lower molar teeth of one randomly selected side received a 2-day temporarily separation. Bitewing radiographs and silicone impressions of interproximal area (IPA) were obtained...
July 22, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28735464/radiation-dose-reduction-in-thoracic-and-lumbar-spine-instrumentation-using-navigation-based-on-an-intraoperative-cone-beam-ct-imaging-system-a-prospective-randomized-clinical-trial
#3
Nathalie Pireau, Virginie Cordemans, Xavier Banse, Nadia Irda, Sébastien Lichtherte, Ludovic Kaminski
PURPOSE: Spine surgery still remains a challenge for every spine surgeon, aware of the potential serious outcomes of misplaced instrumentation. Though many studies have highlighted that using intraoperative cone beam CT imaging and navigation systems provides higher accuracy than conventional freehand methods for placement of pedicle screws in spine surgery, few studies are concerned about how to reduce radiation exposure for patients with the use of such technology. One of the main focuses of this study is based on the ALARA principle (as low as reasonably achievable)...
July 22, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28735463/impact-of-pioglitazone-on-bone-mineral-density-and-bone-marrow-fat-content
#4
L M Pop, I Lingvay, Q Yuan, X Li, B Adams-Huet, N M Maalouf
Pioglitazone use is associated with an increased risk of fractures. In this randomized, placebo-controlled study, pioglitazone use for 12 months was associated with a significant increase in bone marrow fat content at the femoral neck, accompanied by a significant decrease in total hip bone mineral density. The change in bone marrow fat with pioglitazone use was predominantly observed in female vs. male participants. INTRODUCTION: Use of the insulin sensitizer pioglitazone is associated with greater fracture incidence, although the underlying mechanisms are incompletely understood...
July 22, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28735449/therapy-with-omeprazole-modulates-regulatory-t-cell-t-helper-17-immune-response-in-children-with-duodenal-ulcers
#5
Chuan-Ying Li, Cheng Wu
The purpose of this study was to determine the effect of omeprazole on the regulatory T cell (Treg) and T helper 17 (Th17)-mediated response in patients with duodenal ulcers (DUs). DU patients were randomly divided into omeprazole and colloid bismuth subcitrate treatment groups. The ratios of Th17 and Treg in peripheral blood mononuclear cells (PBMCs) were measured. Cytokine production and Foxp3(+)- and RORγt-positive cells were detected. The expressions of STAT3, p-STAT3, STAT5 and p-STAT5 were detected by Western blot...
July 22, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28735384/influence-of-feeding-inorganic-vanadium-on-growth-performance-endocrine-variables-and-biomarkers-of-bone-health-in-crossbred-calves
#6
Ravi Prakash Pal, Veena Mani, Deepika Tripathi, Rajesh Kumar, Neelam J Kewalramani
The nutritional essentialities of transition element vanadium (V) as micro-nutrient in farm animals have not yet been established, though in rat model, vanadium as vanadate has been reported to exert insulin-mimetic effect and shown to be needed for proper development of bones. The objective of this study was to determine the effect of V supplementation on growth performance, plasma hormones and bone health status in calves. Twenty-four crossbred calves (body weight 72.83 ± 2.5 kg; age 3-9 months) were blocked in four groups and randomly assigned to four treatment groups (n = 6) on body weight and age basis...
July 22, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28735354/transplantation-sites-for-human-and-murine-islets
#7
Rebecca A Stokes, Kim Cheng, Amit Lalwani, Michael M Swarbrick, Helen E Thomas, Thomas Loudovaris, Tom W Kay, Wayne J Hawthorne, Philip J O'Connell, Jenny E Gunton
AIMS/HYPOTHESIS: Beta cell replacement is a potential cure for type 1 diabetes. In humans, islet transplants are currently infused into the liver via the portal vein, although this site has disadvantages. Here, we investigated alternative transplantation sites for human and murine islets in recipient mice, comparing the portal vein with quadriceps muscle and kidney, liver and spleen capsules. METHODS: Murine islets were isolated from C57BL6/J mice and transplanted into syngeneic recipients...
July 22, 2017: Diabetologia
https://www.readbyqxmd.com/read/28735307/influence-of-pseudomonas-and-bacillus-strains-isolated-from-lolium-perenne-rhizospheric-soil-in-vojvodina-serbia-on-planth-growth-and-soil-microbial-communities
#8
Stamenov R Dragana, Simonida Đurić, Timea I Hajnal Jafari, Snezana Anđelković
The aim of this study was the isolation of Pseudomonas sp. and Bacillus sp. strains from rhizospheric soil and monitoring the impact of two isolates denoted as P12 (Pseudomonas sp.) and B1 (Bacillus sp.) on the parameters of English ryegrass (Lolium perenne) yield and activity of the soil microbial communities. During 2012-2014, a plot experiment was set up following the randomized block system. Better effect on the plant growth was recorded with the use of Pseudomonas sp. P12 isolate than with Bacillus sp...
July 6, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/28735229/synthetic-antibody-mimics-for-the-inhibition-of-protein-ligand-interactions
#9
REVIEW
Christina Haußner, Johannes Lach, Jutta Eichler
The rational/structure-based design and/or combinatorial development of molecules capable of selectively binding to a protein, represents a promising strategy for a range of biomedical applications, in particular the inhibition of disease-associated protein-ligand interactions. The design of such protein binding molecules is often based on an antibody against the target protein, or involves the generation of smaller molecules that retain the binding characteristics of the antibody. Alternatively, protein binding molecules can be selected from protein libraries based on small, stably folded protein scaffolds presenting flexible loops, which are randomized in the libraries...
July 20, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28735222/effect-of-oleic-acid-on-the-properties-of-protein-adsorbed-layers-at-water-oil-interfaces-an-epr-study-combined-with-dynamic-interfacial-tension-measurements
#10
Eleni P Kalogianni, Leandros Sklaviadis, Stella Nika, Ioanna Theochari, Georgia Dimitreli, Despoina Georgiou, Vassiliki Papadimitriou
Multiphase food systems consist of complex interfacial layers where surface active molecules complete compete for adsorption and interact with one another affecting the interfacial properties and the behavior of the food systems involved. The present work focuses on the examination of interactions between proteins playing an which play an important role in milk-rich food systems (namely κ-casein and β-lactoglobulin) and oleic acid (an anionic surfactant abundant in food systems) at the oil/water interface...
July 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28735202/effect-of-wii-fit%C3%A2-exercise-therapy-on-gait-parameters-in-ankle-sprain-patients-a-randomized-controlled-trial
#11
Ilona M Punt, Stéphane Armand, Jean-Luc Ziltener, Lara Allet
Ankle sprains are the most common sport related injuries. An alternative to physical therapy in the treatment of ankle sprains is home based exercise therapy. This study aims to compare the effectiveness of Wii Fit™ exercise therapy in ankle sprain patients on temporal-spatial and kinematic gait parameters with a) conventional therapy and b) a control group not receiving exercise therapy. Ninety patients were randomly assigned to a Wii Fit™, physical therapy or control group. Temporal-spatial and kinematic gait parameters were assessed at baseline, 6 weeks and 6 months follow-up...
June 29, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28735178/development-of-a-real-time-prediction-model-of-driver-behavior-at-intersections-using-kinematic-time-series-data
#12
Yaoyuan V Tan, Michael R Elliott, Carol A C Flannagan
As connected autonomous vehicles (CAVs) enter the fleet, there will be a long period when these vehicles will have to interact with human drivers. One of the challenges for CAVs is that human drivers do not communicate their decisions well. Fortunately, the kinematic behavior of a human-driven vehicle may be a good predictor of driver intent within a short time frame. We analyzed the kinematic time series data (e.g., speed) for a set of drivers making left turns at intersections to predict whether the driver would stop before executing the turn...
July 20, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28735173/detached-mindfulness-reduced-both-depression-and-anxiety-in-elderly-women-with-major-depressive-disorders
#13
Mohammad Ahmadpanah, Tayebe Akbari, Amineh Akhondi, Mohammad Haghighi, Leila Jahangard, Dena Sadeghi Bahmani, Hafez Bajoghli, Edith Holsboer-Trachsler, Serge Brand
We investigated the influence of detached mindfulness (DM) in treating symptoms of depression and anxiety among elderly women. Thirty-four elderly females (mean age: 69.23 years) suffering from moderate major depressive disorders (MDD) and treated with a standard medication (citalopram) at therapeutic doses were randomly assigned either to an intervention condition (DM; group treatment, twice weekly) or to a control condition (with leisure activities, twice weekly). At baseline (BL), four weeks later at study completion (SC), and four weeks after that at follow-up (FU), participants completed ratings for symptoms of depression and anxiety; experts blind to patients' group assignments rated patients' symptoms of depression...
July 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28735167/first-observation-of-metal-ion-induced-structural-fluctuations-of-%C3%AE-helical-peptides-by-using-diffracted-x-ray-tracking
#14
Daiki Usui, Satomi Inaba, Hiroshi Sekiguchi, Yuji C Sasaki, Toshiki Tanaka, Masayuki Oda
In order to analyze protein structural dynamics, we designed simple model peptides whose structures changed from random-coil to helix-bundle structures by forming stable hydrophobic core in the presence of metal ions. The strategy involved destabilizing a de novo designed three helix-bundle protein by substituting the residues present in its hydrophobic core with histidine and small amino acids. The conformational changes of peptides induced upon binding of Zn(2+) to histidine were analyzed using circular dichroism spectroscopy, which revealed peptides, HA and HG, to be good candidates for further analyses...
July 14, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28735154/accuracy-of-c-reactive-protein-as-a-bacterial-infection-marker-in-critically-immunosuppressed-patients-a-systematic-review-and-meta-analysis
#15
REVIEW
Vanessa Martins de Oliveira, Rafael Barberena Moraes, Airton Tetelbom Stein, Eliana Márcia Wendland
BACKGROUND: There is a need for a better understanding of the role of C-reactive protein (CRP) as a valid marker for the detection of bacterial infections in critically immunosuppressed patients. A high negative predictive value of CRP is also needed to rule out sepsis and bacterial infections in immunocompetent patients. However, few studies have evaluated the performance of CRP in immunocompromised hosts. The aim of the present study was to evaluate the performance of CRP as a marker of infection in critically immunosuppressed patients...
July 15, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28735105/inherent-inferior-quality-of-follicular-fluid-in-repeat-breeder-heifers-as-evidenced-by-low-rates-of-in%C3%A2-vitro-production-of-bovine-embryos
#16
M Kafi, M Azari, O Chashnigir, S Gharibzadeh, Z Aghabozorgi, A Asaadi, M R Divar
The aims of the present study were to determine the effect of follicular fluid obtained from the ovulatory follicle of repeat breeder heifers on in vitro oocyte maturation (Experiment 1), fertilization (Experiment 2) and production of bovine embryos (Experiment 3). Holstein virgin heifers (VH, n = 5) with normal fertility or repeat breeder syndrome (RBH, n = 5) were used in the present study. Follicular fluid of VH and RBH was aspirated from ovulatory follicles and used as maturation medium. Bovine oocytes were aspirated from follicles of slaughterhouse ovaries and randomly allocated in three groups; in Group 1, oocytes cultured in TCM-199 supplemented with 10% heat-treated fetal calf serum and hormones (5 IU/mL hCG plus 0...
July 16, 2017: Theriogenology
https://www.readbyqxmd.com/read/28735085/minocycline-attenuates-streptomycin-induced-cochlear-hair-cell-death-by-inhibiting-protein-nitration-and-poly-adp-ribose-polymerase-activation
#17
Ping Wang, Haonan Li, Shuyuan Yu, Peng Jin, Abdurahman Hassan, Bo Du
This study aimed to elucidate the protective effect of minocycline against streptomycin-induced damage of cochlear hair cells and its mechanism. Cochlear membranes were isolated from newborn Wistar rats and randomly divided into control, 500μmol/L streptomycin, 100μmol/L minocycline, and streptomycin and minocycline treatment groups. Hair cell survival was analyzed by detecting the expression of 3-nitrotyrosine (3-NT) in cochlear hair cells by immunofluorescence and an enzyme-linked immunosorbent assay. Expression of 3-NT and inducible nitric oxide synthase (iNOS), and poly (ADP-Ribose) polymerase (PARP) and caspase-3 activation were evaluated by western blotting...
July 19, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28735036/proactive-tobacco-treatment-for-individuals-with-and-without-a-mental-health-diagnosis-secondary-analysis-of-a-pragmatic-randomized-controlled-trial
#18
Sandra J Japuntich, Scott E Sherman, Anne M Joseph, Barbara Clothier, Siamak Noorbaloochi, Elisheva Danan, Diana Burgess, Erin Rogers, Steven S Fu
INTRODUCTION: Individuals with (vs. without) mental illness use tobacco at higher rates and have more difficulty quitting. Treatment models for smokers with mental illness are needed. METHODS: This secondary analysis of the Victory Over Tobacco study [a pragmatic randomized clinical trial (N=5123) conducted in 2009-2011 of Proactive Care (proactive outreach plus connection to smoking cessation services) vs. Usual Care] tests the effectiveness of treatment assignment in participants with and without a mental health diagnosis on population-level, 6month prolonged abstinence at one year follow-up...
July 15, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28734971/robotic-assistance-confers-ambidexterity-to-laparoscopic-surgeons
#19
Souzana Choussein, Serene S Srouji, Leslie V Farland, Ashley Wietsma, Stacey A Missmer, Michael Hollis, Richard N Yu, Charles N Pozner, Antonio R Gargiulo
STUDY OBJECTIVE: To examine whether a robotic surgical platform can complement the fine motor skills of the non-dominant hand, compensating for the innate difference in dexterity between the surgeon's hands, thereby conferring virtual ambidexterity. DESIGN: Crossover intervention study. DESIGN CLASSIFICATION: Level II-1 evidence. SETTING: Centers for medical simulation of two tertiary care hospitals of Harvard Medical School...
July 19, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28734951/emergency-department-management-of-diabetic-ketoacidosis-and-hyperosmolar-hyperglycemic-state-national-survey-of-attitudes-and-practice
#20
Alexandra L Hamelin, Justin W Yan, Ian G Stiell
OBJECTIVES: In 2013, the Association, now Diabetes Canada, published national clinical practice guidelines for the effective management of diabetic ketoacidosis and hyperosmolar hyperglycemic states in adults. We sought to determine emergency physician compliance rates and attitudes toward these guidelines and to identify potential barriers to their use in Canadian emergency departments. METHODS: An online survey consisting of questions related to the awareness and use of the Canadian Diabetes Association 2013 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada was distributed to 500 randomly selected members of the Canadian Association of Emergency Physicians...
July 19, 2017: Canadian Journal of Diabetes
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