Emanuele Azzi, Diego Alberti, Stefano Parisotto, Alberto Oppedisano, Nicoletta Protti, Saverio Altieri, Simonetta Geninatti-Crich, Annamaria Deagostino
Curcumin is currently being investigated for its capacity to treat many types of cancer and to prevent the neuron damage that is observed in Alzheimer's disease (AD). However, its clinical use is limited by its low stability and solubility in aqueous solutions. In this study, we propose a completely new class of boronated monocarbonyl analogues of Curcumin (BMAC, 6a-c), in which a carbonyl group replaces the Curcumin β-diketone functionality, and an ortho-carborane, an icosahedral boron cluster, substitutes one of the two phenolic rings...
December 2019: Bioorganic Chemistry