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https://www.readbyqxmd.com/read/28221027/assessing-the-biocidal-activity-and-investigating-the-mechanism-of-oligo-p-phenylene-ethynylenes
#1
Jing Wang, Lian-Gang Zhuo, Wei Liao, Xia Yang, Zhenghua Tang, Yue Chen, Shunzhong Luo, Zhijun Zhou
A number of oligo-p-phenylene-ethynylenes (OPEs) have exhibited excellent biocidal activity against both Gram-negative and Gram-positive bacteria. While cell death may occur in the dark, these biocidal compounds are far more effective in the light as a result of their abilities to generate cell-damaging reactive oxygen species. In this study, the interactions of four OPEs with E.coli and S.aureus have been investigated. Compared to the OPEs with quaternary ammonium salts (Q-OPE), the OPEs with tertiary ammonium (T-OPE) effectively kills many more bacterial cells under light irradiation, presumably by severe perturbations of the bacterial cell wall and cytoplasmic membrane...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28216302/long-term-antimicrobial-effect-of-nisin-released-from-electrospun-triaxial-fiber-membranes
#2
Daewoo Han, Shalli Sherman, Shaun Filocamo, Andrew J Steckl
: Electrospun membranes encapsulating nisin in the core of multi-layer coaxial fibers, with a hydrophobic PCL intermediate layer and a hygroscopic cellulose acetate sheath, have been demonstrated to provide long-term antimicrobial activity combined with a hygroscopic outer layer. Antimicrobial performance has been evaluated using modified versions of the antimicrobial textile test AATCC 100 and AATCC 147 against Staphylococcus aureus. The AATCC 147 tests indicate that antimicrobial activity persists up to 7 days...
February 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28212512/are-antifouling-paint-particles-a-continuous-source-of-toxic-chemicals-to-the-marine-environment
#3
Sanye Soroldoni, Fiamma Abreu, Ítalo Braga Castro, Fabio Andrei Duarte, Grasiela Lopes Leães Pinho
Antifouling paint particles (APPs) are generated during periodical maintenance of boat hulls. Chemical composition and toxicity (either chronic or acute) of APPs found in the sediment was evaluated using the epibenthic copepod Nitokra sp. The APPs analyzed showed the presence of high levels of metals such as Cu (234,247±268μgg(-1)), Zn (112,404±845μgg(-1)) and the booster biocide DCOIT (0.13μgg(-1)). Even at low concentrations (as from 5mgg(-1) of APPs by mass of sediment) a significantly decrease in the fecundity was observed in laboratory tests...
February 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28210242/biocidal-inactivation-of-lactococcus-lactis-bacteriophages-efficacy-and-targets-of-commonly-used-sanitizers
#4
Stephen Hayes, James Murphy, Jennifer Mahony, Gabriele A Lugli, Marco Ventura, Jean-Paul Noben, Charles M A P Franz, Horst Neve, Arjen Nauta, Douwe Van Sinderen
Lactococcus lactis strains, being intensely used in the dairy industry, are particularly vulnerable to members of the so-called 936 group of phages. Sanitization and disinfection using purpose-made biocidal solutions is a critical step in controlling phage contamination in such dairy processing plants. The susceptibility of 36 936 group phages to biocidal treatments was examined using 14 biocides and commercially available sanitizers. The targets of a number of these biocides were investigated by means of electron microscopic and proteomic analyses...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28209895/seagrass-ecosystems-reduce-exposure-to-bacterial-pathogens-of-humans-fishes-and-invertebrates
#5
Joleah B Lamb, Jeroen A J M van de Water, David G Bourne, Craig Altier, Margaux Y Hein, Evan A Fiorenza, Nur Abu, Jamaluddin Jompa, C Drew Harvell
Plants are important in urban environments for removing pathogens and improving water quality. Seagrass meadows are the most widespread coastal ecosystem on the planet. Although these plants are known to be associated with natural biocide production, they have not been evaluated for their ability to remove microbiological contamination. Using amplicon sequencing of the 16S ribosomal RNA gene, we found that when seagrass meadows are present, there was a 50% reduction in the relative abundance of potential bacterial pathogens capable of causing disease in humans and marine organisms...
February 17, 2017: Science
https://www.readbyqxmd.com/read/28207828/the-wide-spectrum-high-biocidal-potency-of-bioxy-formulation-when-dissolved-in-water-at-different-concentrations
#6
Dori Dagher, Ken Ungar, Richard Robison, Fadi Dagher
Traditional surface disinfectants that have long been applied in medicine, animal husbandry, manufacturing and institutions are inconvenient at best and dangerous at worst. Moreover, some of these substances have adverse environmental impacts: for example, quaternary ammonium compounds ("quats") are reproductive toxicants in both fish and mammals. Halogens are corrosive both to metals and living tissues, are highly reactive, can be readily neutralized by metals, and react with organic matter to form toxic, persistent by-products such as dioxins and furans...
2017: PloS One
https://www.readbyqxmd.com/read/28202579/occupational-exposure-to-pesticides-and-other-biocides-and-risk-of-thyroid-cancer
#7
Fanhua Zeng, Catherine Lerro, Jérôme Lavoué, Huang Huang, Jack Siemiatycki, Nan Zhao, Shuangge Ma, Nicole C Deziel, Melissa C Friesen, Robert Udelsman, Yawei Zhang
OBJECTIVES: To assess the associations between occupational exposure to biocides and pesticides and risk of thyroid cancer. METHODS: Using data from a population-based case-control study involving 462 incident thyroid cancer cases and 498 controls in Connecticut collected in 2010-2011, we examined the association with occupational exposure to biocides and pesticides through a job-exposure matrix. We used unconditional logistic regression models to estimate OR and 95% CI, adjusting for potential confounders...
February 15, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28202348/assessment-of-environmental-risks-to-groundwater-ecosystems-related-to-use-of-veterinary-medicinal-products
#8
Boris Kolar, Antonio Finizio
The current EU guidelines for the environmental risk assessment of veterinary pharmaceutical products (VMPs) in groundwater (GW) suggest an approach based on the comparison between the calculated concentration in GW (PECgw) and a threshold concentration of 0.1 μg/L. The latter is the upper limit of the concentration for pesticides in groundwater in the EU. If the calculated PECgw does not exceed the threshold, then the risk is considered acceptable. It is assumed that the concentration of 0.1 μg/L is by default safe for both humans and exposed GW organisms...
February 12, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28194876/biocidal-efficacy-of-multipurpose-solutions-against-gram-negative-organisms-associated-with-corneal-infiltrative-events
#9
Denise Callahan, Christopher Kovacs, Shawn Lynch, Marjorie Rah
BACKGROUND: Because corneal infiltrative events (CIEs) may result from bacterial components on contact lenses, which can come from contaminated lens cases, we evaluated the biocidal efficacy of five multipurpose solutions against Gram-negative commonly isolated and CIE-associated organisms. METHODS: Of the multipurpose solutions tested, one contained polyhexamethylene biguanide (PHMB)/polyquaternium-1 (PQ-1; Bausch & Lomb Incorporated: Biotrue), one contained alexidine dihydrochloride (alexidine)/PQ-1 (AMO: RevitaLens OcuTec) and three contained PQ-1/myristamidopropyl dimethylamine (MAPD; Alcon: Opti-Free PureMoist, PQ-1/MAPD-1; Opti-Free RepleniSH, PQ-1/MAPD-2; Opti-Free Express, PQ-1/MAPD-3)...
February 14, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28192222/antifungal-effectiveness-of-fungicide-and-peroxyacetic-acid-mixture-on-the-growth-of-botrytis-cinerea
#10
Fatima Ayoub, Najwa Ben Oujji, Bouchra Chebli, Mohamed Ayoub, Athman Hafidi, Rachid Salghi, Shehdeh Jodeh
In the attempt to reduce the negative impacts of chemical pesticides on environment and consumer's health, a new plant treatment practice minimizing the amount of pesticides needed during pests and diseases treatments has been developed. Our approach is based on combining the biocide effects of fungicide with the peroxyacetic acid (PAA) one. In this paper, we focused on the in vitro study of the antifungal activity of this combination against Botrytis cinerea, the most redoubtable threat of tomatoes plants in Morocco...
February 10, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28186134/virulence-inhibitors-from-brazilian-peppertree-block-quorum-sensing-and-abate-dermonecrosis-in-skin-infection-models
#11
Amelia Muhs, James T Lyles, Corey P Parlet, Kate Nelson, Jeffery S Kavanaugh, Alexander R Horswill, Cassandra L Quave
Widespread antibiotic resistance is on the rise and current therapies are becoming increasingly limited in both scope and efficacy. Methicillin-resistant Staphylococcus aureus (MRSA) represents a major contributor to this trend. Quorum sensing controlled virulence factors include secreted toxins responsible for extensive damage to host tissues and evasion of the immune system response; they are major contributors to morbidity and mortality. Investigation of botanical folk medicines for wounds and infections led us to study Schinus terebinthifolia (Brazilian Peppertree) as a potential source of virulence inhibitors...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183020/biocides-in-wastewater-treatment-plants-mass-balance-analysis-and-pollution-load-estimation
#12
Wang-Rong Liu, Yuan-Yuan Yang, You-Sheng Liu, Li-Juan Zhang, Jian-Liang Zhao, Qian-Qian Zhang, Min Zhang, Jin-Na Zhang, Yu-Xia Jiang, Guang-Guo Ying
This study aimed to investigate the occurrence and removal of 19 biocides in ten different wastewater treatment plants (WWTPs), then estimate the usages and emissions per capita of 19 biocides based on mass balance analysis approach. The results showed that target biocides were universally detected in the WWTPs and their receiving rivers, and 19 for liquid samples and 18 for solid samples. The prominent compound for liquid was DEET (N,N-diethyl-3-methylbenzamide), with its maximum concentration of 393ng/L in influent; while that for solid was triclocarban with its maximum concentration of 2...
February 1, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28177232/adaptation-to-biocides-cetrimide-and-chlorhexidine-in-bacteria-from-organic-foods-association-with-tolerance-to-other-antimicrobials-and-physical-stresses
#13
Rebeca Gadea, Nicolas Glibota, Ruben Pérez Pulido, Antonio Galvez, Elena Ortega
Chlorhexidine (CH) and quaternary ammonium compounds (QAC), like cetrimide (CE) are widely used as disinfectants because of their broad antimicrobial spectrum. However, their frequent use for disinfection in different settings may promote bacterial drug resistance against both biocides and clinically relevant antibiotics. This study analyzes the effects of step-wise exposure to cetrimide (CE) and chlorhexidine (CH) of bacteria from organic foods and previously classified as sensitive to biocides. Gradual exposure of these strains to biocides resulted in mainly transient decreased antimicrobial susceptibility to other biocides and to antibiotics...
February 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28165522/classification-of-baseline-toxicants-for-qsar-predictions-to-replace-fish-acute-toxicity-studies
#14
Monika Nendza, Martin Müller, Andrea Wenzel
Fish acute toxicity studies are required for environmental hazard and risk assessment of chemicals by national and international legislations such as REACH, the regulations of plant protection products and biocidal products, or the GHS (globally harmonised system) for classification and labelling of chemicals. Alternative methods like QSARs (quantitative structure-activity relationships) can replace many ecotoxicity tests. However, complete substitution of in vivo animal tests by in silico methods may not be realistic...
February 6, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28161095/environmental-obesogen-tributyltin-chloride-leads-to-abnormal-hypothalamic-pituitary-gonadal-axis-function-by-disruption-in-kisspeptin-leptin-signaling-in-female-rats
#15
Gabriela C Sena, Leandro C Freitas-Lima, Eduardo Merlo, Priscila L Podratz, Julia F P de Araújo, Poliane A A Brandão, Maria T W D Carneiro, Marina C Zicker, Adaliene V M Ferreira, Christina M Takiya, Carolina M de Lemos Barbosa, Marcelo M Morales, Ana Paula Santos-Silva, Leandro Miranda-Alves, Ian V Silva, Jones B Graceli
Tributyltin chloride (TBT) is a xenobiotic used as a biocide in antifouling paints that has been demonstrated to induce endocrine-disrupting effects, such as obesity and reproductive abnormalities. An integrative metabolic control in the hypothalamus-pituitary-gonadal (HPG) axis was exerted by leptin. However, studies that have investigated the obesogenic TBT effects on the HPG axis are especially rare. We investigated whether metabolic disorders as a result of TBT are correlated with abnormal hypothalamus-pituitary-gonadal (HPG) axis function, as well as kisspeptin (Kiss) action...
March 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28159795/predominance-and-metabolic-potential-of-halanaerobium-in-produced-water-from-hydraulically-fractured-marcellus-shale-wells
#16
Daniel Lipus, Amit Vikram, Daniel Ross, Daniel Bain, Djuna Gulliver, Richard Hammack, Kyle Bibby
: Microbial activity in the produced water from hydraulically fractured oil and gas wells may potentially interfere with hydrocarbon production and cause damage to the well and surface infrastructure via corrosion, sulfide release, and fouling. In this study, we surveyed the microbial abundance and community structure of produced water sampled from 42 Marcellus Shale wells in southwestern Pennsylvania (well age ranged from 150 to 1846 days) to better understand the microbial diversity of produced water...
February 3, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28158762/identification-and-biocide-susceptibility-of-dominant-bacteria-after-cleaning-and-disinfection-of-broiler-houses
#17
K Luyckx, E Van Coillie, J Dewulf, S Van Weyenberg, L Herman, J Zoons, E Vervaet, M Heyndrickx, K De Reu
No abstract text is available yet for this article.
October 27, 2016: Poultry Science
https://www.readbyqxmd.com/read/28151960/d-amino-acids-reduce-enterococcus-faecalis-biofilms-in-vitro-and-in-the-presence-of-antimicrobials-used-for-root-canal-treatment
#18
Peter S Zilm, Victor Butnejski, Giampiero Rossi-Fedele, Stephen P Kidd, Suzanne Edwards, Krasimir Vasilev
Enterococcus faecalis is the most frequent species present in post-treatment disease and plays a significant role in persistent periapical infections following root canal treatment. Its ability to persist in stressful environments is inter alia, due to its ability to form biofilms. The presence of certain D-amino acids (DAAs) has previously been shown to reduce formation of Bacillus subtilis biofilms. The aims of this investigation were to determine if DAAs disrupt biofilms in early and late growth stages for clinical E...
2017: PloS One
https://www.readbyqxmd.com/read/28145683/evidence-for-the-phospholipid-sponge-effect-as-the-biocidal-mechanism-in-surface-bound-polyquaternary-ammonium-coatings-with-variable-cross-linking-density
#19
Jing Gao, Evan M White, Qiaohong Liu, Jason Locklin
Poly quaternary "-oniums" derived from polyethylenimine (PEI), poly(vinyl-N-alkylpyridinium), or chitosan belong to a class of cationic polymers that are efficient antimicrobial agents. When dissolved in solution, the positively charged polycations are able to displace the divalent cations of the cellular phospholipid bilayer and disrupt the ionic cross-links and structural integrity of the membrane. However, when immobilized to a surface where confinement limits diffusion, poly -oniums still show excellent antimicrobial activity, which implies a different biocidal mode of action...
February 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28133508/effects-of-didecyldimethylammonium-chloride-ddac-on-sprague-dawley-rats-after-13-weeks-of-inhalation-exposure
#20
Yong-Soon Kim, Sung-Bae Lee, Cheol-Hong Lim
Didecyldimethylammonium chloride (DDAC) is used in many types of biocidal products including tableware, carpets, humidifiers, and swimming pools, etc. In spite of increased chances of DDAC exposure through inhalation, studies on the inhalation toxicity of DDAC are not common even though the toxicity of DDAC might be significantly higher if it were to be administered through routes other than the respiratory system. DDAC aerosols were exposed to Sprague-Dawley rats in whole body exposure chambers for a duration of 13 weeks...
January 2017: Toxicological Research
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