Read by QxMD icon Read


Anna Koziróg, Bogumił Brycki, Katarzyna Pielech-Przybylska
This study investigates the biological activity of two cationic gemini surfactants, hexamethylene-1,6-bis-( N , N -dimethyl- N -dodecylammonium bromide) C6 and pentamethylene-1,5-bis-( N , N -dimethyl- N -dodecyla,.mmonium bromide) C5, and their two neutral analogs, hexamethylene-1,6-bis-( N -methyl- N -dodecylamine) (A6) and pentamethylene-1,5-bis-( N -methyl- N -dodecylamine) (A5). Experiments were performed with Aspergillus brasiliensis , which is used in the standard tests for biocides. The minimal inhibitory concentration (MIC) values for conidia and mycelium were determined using the dilution method...
March 15, 2018: International Journal of Molecular Sciences
Luís Belo, Isa Serrano, Eva Cunha, Carla Carneiro, Luis Tavares, L Miguel Carreira, Manuela Oliveira
BACKGROUND: Most of surgical site infections (SSI) are caused by commensal and pathogenic agents from the patient's microbiota, which may include antibiotic resistant strains. Pre-surgical asepsis of the skin is one of the preventive measures performed to reduce SSI incidence and also antibiotic resistance dissemination. However, in veterinary medicine there is no agreement on which biocide is the most effective. The aim of this study was to evaluate the effectiveness of two pre-surgical skin asepsis protocols in dogs...
March 14, 2018: BMC Veterinary Research
Arwa Abu Khweek, Amal O Amer
Legionella pneumophila ( L. pneumophila ) is an opportunistic waterborne pathogen and the causative agent for Legionnaires' disease, which is transmitted to humans via inhalation of contaminated water droplets. The bacterium is able to colonize a variety of man-made water systems such as cooling towers, spas, and dental lines and is widely distributed in multiple niches, including several species of protozoa In addition to survival in planktonic phase, L. pneumophila is able to survive and persist within multi-species biofilms that cover surfaces within water systems...
2018: Frontiers in Cellular and Infection Microbiology
Susanne Sütterlin, Carlos J Téllez-Castillo, Leticia Anselem, Hong Yin, James E Bray, Martin C J Maiden
Antimicrobial resistance is a major health care problem, with the intensive use of heavy metals and biocides recently being identified as potential contributing factors to the aggravation of this situation. This study investigated heavy metal susceptibility and genetic resistance determinants in Escherichia coli isolated from clinical urine samples from Sweden, Germany and Spain. A total of 186 isolates were tested for minimal inhibition concentration to sodium arsenite, silver nitrate and copper (II) sulphate...
March 12, 2018: Antimicrobial Agents and Chemotherapy
Alex G Baldwin, Jonathan Bevan, David Brough, Ruth Ledder, Sally Freeman
Dehydroacetic acid is a common pyrone derivative used commercially as an antibacterial and antifungal agent. Based on the synthesis of dehydroacetic acid ( 1 ) from N -hydroxysuccinimdyl acetoacetate, a novel series of enamine-based derivatives were synthesised in order to improve the antibacterial activity of dehydroacetic acid. The antibacterial activities of the synthesised analogues were evaluated against Escherichia coli and Staphylococcus aureus . Derivative 4d (N-Ph) was identified as the most potent inhibitor of S...
2018: Medicinal Chemistry Research
Tiffany Malleck, Guillaume Daufouy, Stéphane André, Véronique Broussolle, Stella Planchon
Temperatures encountered in cannery allow growth of thermophilic spore-forming bacteria, including the strictly anaerobe Moorella thermoacetica, which grows optimally from 55 °C to 65 °C and is the main cause of spoilage of low-acid canned foods (LACFs) at high temperature. Resistance to wet-heat, biocides and UV-C of spores formed at different temperatures was assessed either for a selection of M. thermoacetica strains or for the strain M. thermoacetica ATCC 39073. Spores formed at 45 °C were significantly more sensitive to wet-heat than spores produced at 55 °C, while spores produced at 65 °C were as heat-resistant as spores produced at 55 °C...
August 2018: Food Microbiology
Sanye Soroldoni, Ítalo Braga Castro, Fiamma Abreu, Fabio Andrei Duarte, Rodrigo Brasil Choueri, Osmar Olinto Möller, Gilberto Fillmann, Grasiela Lopes Leães Pinho
Sources, occurrence, composition and dynamics of antifouling paint particles (APPs) were assessed in Patos Lagoon estuary (PLE), Southern Brazil. Ten areas including boatyards, a marina and artisanal fishing harbors were identified in the estuarine system as potential sources of APPs. The APPs generated in these areas were highly heterogeneous considering the size, shape and composition. Based on an estimate of antifouling paint usage and amount of boats in each studied area, artisanal fishing harbors could be the main source of particles to PLE...
March 2, 2018: Water Research
Kate A Worthing, Alan Marcus, Sam Abraham, Darren J Trott, Jacqueline M Norris
Qac genes are associated with increased tolerance to quaternary ammonium compounds and other cationic biocides such as chlorhexidine. This study aimed to determine whether qac genes and increased biocide tolerance were present in 125 clinical methicillin-resistant and susceptible veterinary staphylococci. A total of 125 methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant and -susceptible Staphylococcus pseudintermedius (MRSP and MSSP) from three archived Australian veterinary staphylococci collections underwent whole genome sequencing, multilocus sequence typing and qac gene screening...
March 2018: Veterinary Microbiology
Steven Caskey, John E Moore, Jacqueline C Rendall
Background: Mycobacterium abscessus pulmonary infection has recently emerged as a significant pathogen in patients with cystic fibrosis (CF) and is associated with significant morbidity and accelerated pulmonary decline. There is a paucity of data describing the activity of hospital biocides against this organism. Methods: M. abscessus isolates (n = 13) were recovered from CF and non-CF respiratory specimens. Seven commonly employed hospital biocides with generic ingredients as follows: acetone, propan-2-ol, diethylene glycol, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, chlorine dioxide, 4% chlorhexidine, alcohol, and disodium carbonate, compound with hydrogen peroxide, 10% sodium hypochlorite were assayed for their biocidal activity against M...
January 2018: International Journal of Mycobacteriology
Anja Coors, Pia Vollmar, Frank Sacher, Anja Kehrer
Products used for plant protection or as biocides often contain more than one active substance together with numerous formulation additives. The environmental risk assessment for such commercial mixtures applies as default the concept of concentration addition. There is remaining regulatory concern, however, that underestimation of risks can occur if components in the mixture interact synergistically, i.e., elicit effects greater than those predicted by concentration addition. While cases of true synergism appear to be rare, the combination of substances targeting different steps in the same biosynthesis pathway was pointed out as one potential case of synergistic interaction although mechanistic explanations are lacking...
March 2, 2018: Ecotoxicology
Abdulrahman S Bazaid, Sarah Forbes, Gavin J Humphreys, Ruth G Ledder, Ronan O'Cualain, Andrew J McBain
Staphylococcus aureus can develop a small colony variant (SCV) phenotype in response to sub-lethal exposure to the biocide triclosan. In the current study, whole genome sequencing was performed and changes in virulence were investigated in five Staphylococcus aureus strains following repeated exposure to triclosan. Following exposure, 4/5 formed SCV and exhibited point mutations in the triclosan target gene fabI with 2/4 SCVs showing mutations in both fabI and fabD. The SCV phenotype was in all cases immediately reversed by nutritional supplementation with fatty acids or by repeated growth in the absence of triclosan, although fabI mutations persisted in 3/4 reverted SCVs...
March 1, 2018: Scientific Reports
Hossam E Emam, Osama M Darwesh, Reda M Abdelhameed
Bio-active synthetic fabrics based on polyester (PET) and Nylon were manufactured by in-situ formation of Cu-BTC metal organic framework (MOF). In-growth of Cu-BTC within fabrics was accomplished in one pot simple process. The scanning microscope, X-ray diffraction and infrared spectra were all confirmed the formation of Cu-BTC within fabrics structure and reflected the role of fabrics' building unit in the Cu-BTC preparation. The estimated contents of materials onto fabrics were ranged in 97.14-127.33 mg MOF/g fabric and 30...
February 13, 2018: Colloids and Surfaces. B, Biointerfaces
Munirah Hanapiah, Syaizwan Zahmir Zulkifli, Muskhazli Mustafa, Ferdaus Mohamat-Yusuff, Ahmad Ismail
Diuron is an alternative biocide suggested to replace organotin in formulating antifouling paints to be applied on water-going vessels hull. However, it is potentially harmful to various non-targeted marine organisms due to its toxic properties. Present study aimed to isolate, screen and identify the potential of Diuron-degrading bacteria collected from the marine sediments of Port Klang, Malaysia. Preliminary screening was conducted by exposing isolated bacteria to 430ng/L (background level), followed by 600ng/L and 1000ng/L of Diuron concentrations...
February 2018: Marine Pollution Bulletin
Maria Lagerström, J Fredrik Lindgren, Albin Holmqvist, Mia Dahlström, Erik Ytreberg
Antifouling paints are environmentally risk assessed based on their biocidal release rates to the water phase. In situ release rates of copper (Cu) and zinc (Zn) were derived for five commercial paints in two recreational marinas with different salinities (5 and 14 PSU) using an X-Ray Fluorescence spectrometer (XRF). Salinity was found to significantly affect the Cu release, with twice the amount of Cu released at the higher salinity, while its influence on the Zn release was paint-specific. Site-specific release rates for water bodies with salinity gradients, e...
February 2018: Marine Pollution Bulletin
Marco Artini, Alexandros Patsilinakos, Rosanna Papa, Mijat Božović, Manuela Sabatino, Stefania Garzoli, Gianluca Vrenna, Marco Tilotta, Federico Pepi, Rino Ragno, Laura Selan
Pseudomonas aeruginosa is a ubiquitous organism and opportunistic pathogen that can cause persistent infections due to its peculiar antibiotic resistance mechanisms and to its ability to adhere and form biofilm. The interest in the development of new approaches for the prevention and treatment of biofilm formation has recently increased. The aim of this study was to seek new non-biocidal agents able to inhibit biofilm formation, in order to counteract virulence rather than bacterial growth and avoid the selection of escape mutants...
February 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Katarzyna Malinowska, Ingo-Peter Lorenz, Beata Sadowska, Paulina Mucha
Heterocyclic compounds containing nitrogen ions, like pyrazoles, aziridines, diaziridines and their metal ion complexes with Cu(II), Zn(II) and Ru(III) and others exhibit a wide range of biological activity, including mainly anti-inflammatory, antioxidant, anti-cancer, and antimicrobial properties. Biological significance of these molecules and thus their potential use in medicine has driven growing interest into their coordination chemistry. A knowledge of the relationship between the structure of chemical compounds and their activity is needed for the synthesis of the preparations possessing the most beneficial features...
February 21, 2018: Current Medicinal Chemistry
Liza-Marie Beckers, Wibke Busch, Martin Krauss, Tobias Schulze, Werner Brack
Sites of wastewater discharge are hotspots for pollution of freshwaters with organic micropollutants and are often associated with adverse effects to aquatic organisms. The assessment, monitoring and managment of these hotspots is challenged by variations in the pollutant mixture composition due to season, weather conditions and random spills. In this study, we unraveled temporal exposure patterns in organic micropollutant mixtures from wastewater discharge and analyzed respective acute and sublethal risks for aquatic organisms...
February 3, 2018: Water Research
Duy H K Nguyen, Vy T H Pham, Vi Khanh Truong, Igor Sbarski, James Wang, Armandas Balčytis, Saulius Juodkazis, David E Mainwaring, Russell J Crawford, Elena P Ivanova
Wrinkled patterns, which possess an extensive surface area over a limited planar space, can provide surface features ranging across the nano- and microscale that have become an engineering material with the flexibility to be tuneable for a number of technologies. Here, we investigate the surface parameters that influence the attachment response of two model bacteria (P. aeruginosa and S. aureus) to wrinkled gold-coated polystyrene surfaces having topologies at the nano- and microscale. Together with flat gold films as the controls, surface feature heights spanned 2 orders of magnitude (15 nm, 200 nm, and 1 micron)...
February 20, 2018: Nanoscale
Hanan B Ahmed, Hossam E Emam, Hamada M Mashaly, Mohamed Rehan
The current approach focuses on studying the leverage of nanosilver (AgNPs) incorporation on the dyeing process of viscose fibers by blue reactive dye. Nanosilver was straightway incorporated into viscose fibers using sodium citrate as nanogenerator. Owing to AgNPs incorporation, color of fibers was turned to greenish-blue and darker greenish color was observed with low Ag content (<1 g/kg). Regardless to the processes sequencing, color strength of fibers was magnified by increasing in Ag content. The constancy of fibers color was not affected by AgNPs inclusion, whatever the processes sequencing and Ag content...
April 15, 2018: Carbohydrate Polymers
Adam C Mumford, Denise M Akob, J Grace Klinges, Isabelle M Cozzarelli
The development of unconventional oil and gas (UOG) resources results in production of large volumes of wastewater containing a complex mixture of hydraulic fracturing chemical additives and components from the formation. Release of these wastewaters into the environment poses potential risks that are poorly understood. Microbial communities in stream sediments form the base of the food chain, and may serve as sentinels for changes in stream health. Iron reducing organisms have been shown to play a role in the biodegradation of a wide range of organic compounds, and to evaluate their response to UOG wastewater, we enriched anaerobic microbial communities from sediments collected upstream (background) and downstream (impacted) of an UOG wastewater injection disposal facility in the presence of hydraulic fracturing fluid (HFF) additives: guar gum, ethylene glycol, and two biocides, DBNPA and Bronopol...
February 16, 2018: Applied and Environmental Microbiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"