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Chana G Sokolik, Rina Ben-Shabat-Binyamini, Aharon Gedanken, Jean-Paul Lellouche
There is an urgent need for new materials with antimicrobial activity. Phenolic essential oil (EO) compounds with Generally Recognized As Safe (GRAS) status are attractive candidates, but they need suitable delivery systems to overcome specific drawbacks. Core-shell microspheres (MSs) of Bovine Serum Albumin (BSA) or Human Serum Albumin (HSA) encapsulating such active compounds in the oil phase are a delivery system that is novel in combination with phenolic EO compounds. Moreover, the EO compounds can also be assembled in an oil shell around a protein core by choosing an appropriate oil phase...
March 2018: Ultrasonics Sonochemistry
Sulaiman M I Alotaibi, Alafate Ayibiekea, Annemette Frøling Pedersen, Lotte Jakobsen, Mette Pinholt, Heidi Gumpert, Anette M Hammerum, Henrik Westh, Hanne Ingmer
PURPOSE: In Danish hospitals, the number of infections caused by vancomycin-resistant Enterococcus faecium (VRE faecium) has dramatically increased in recent years. Hospital disinfectants are essential in eliminating pathogenic microorganisms, and reduced susceptibility may contribute to hospital-associated infections. We have addressed whether clinical VRE faecium display decreased biocide susceptibility when compared to vancomycin-sensitive Enterococcus faecium (VSE faecium) isolates...
November 14, 2017: Journal of Medical Microbiology
Supaporn Bouson, Atiweena Krittayavathananon, Nutthaphon Phattharasupakun, Patcharaporn Siwayaprahm, Montree Sawangphruk
Although metal-organic frameworks (MOFs) or porous coordination polymers have been widely studied, their antimicrobial activities have not yet been fully investigated. In this work, antifungal activity of copper-based benzene-tricarboxylate MOF (Cu-BTC MOF), which is water stable and industrially interesting, is investigated against Candida albicans, Aspergillus niger, Aspergillus oryzae and Fusarium oxysporum. The Cu-BTC MOF can effectively inhibit the growth rate of C. albicans and remarkably inhibit the spore growth of A...
October 2017: Royal Society Open Science
Hisanori Iwai
To maintain performance related to fuel consumption and maneuverability, the bottom of ships are painted with antifouling paint that contains Cu2O as a biocidal pigment. However, in enclosed coastal areas around dockyards, some of the Cu(II) contained in the paint is eluted into the surrounding water. The present study examined the removal of Cu from seawater by co-precipitation with humic acids (HAs). After precipitating the HA in seawater, the amount of Cu(II) in the supernatant was colorimetrically measured by a colorimetry using bathocuproine...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Neal Ingraham Callaghan, Kenneth Javier Williams, J Craig Bennett, Tyson James MacCormack
Silver nanoparticles (nAg), due to their biocidal properties, are common in medical applications and are used in more consumer products than any other engineered nanomaterial. This growing abundance, combined with their ability to translocate across the epithelium and bioaccumulate, suggests that internalized nAg may present a risk of toxicity to many organisms in the future. However, little experimentation has been devoted to cardiac responses to acute nAg exposure, even though nAg is known to disrupt ion channels even when ionic Ag(+) does not...
November 9, 2017: Environmental Pollution
Adnan Hossain Khan, Mark Libby, Daniel Winnick, John Palmer, Mark Sumarah, Madhumita B Ray, Sheila M Macfie
Cationic surfactants such as benzalkonium chlorides (BACs) are used extensively as biocides in hospitals, food processing industries, and personal care products. BACs have the potential to reach the rooting zone of crop plants and BACs might thereby enter the food chain. The two most commonly used BACs, benzyl dimethyl dodecyl ammonium chloride (BDDA) and benzyl dimethyl tetradecyl ammonium chloride (BDTA), were tested in a hydroponic system to assess the uptake by and phytotoxicity to lettuce (Lactuca sativa L...
November 8, 2017: Journal of Environmental Management
Sofia Santos Costa, Miguel Viveiros, Constança Pomba, Isabel Couto
Objectives: To analyse the efflux-mediated response of Staphylococcus epidermidis to ethidium bromide (EtBr), a substrate of multidrug efflux pumps (EPs). Methods: The susceptible reference strain S. epidermidis ATCC 12228 was exposed to a step-wise adaptation to EtBr. The resulting EtBr-adapted strains were characterized regarding their antibiotic and biocide susceptibility by MIC determination and evaluation of efflux activity by re-determination of MICs in the presence of known efflux inhibitors and real-time fluorometry...
November 8, 2017: Journal of Antimicrobial Chemotherapy
Chloe A Hae Cho, Chao Liang, Janesha Perera, Jie Liu, Kyriakos G Varnava, Vijayalekshmi Sarojini, Ralph P Cooney, Duncan J McGillivray, Margaret A Brimble, Simon Swift, Jianyong Jin
Six guanidine functionalized aliphatic biodegradable polycarbonates with varying molecular weights and charge densities were synthesized via post-synthesis modification of alkyne containing polycarbonates using Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. The concept of passive diluting group was to modify the cationic charge density of the polycarbonate without changing its hydrophilicity. Within the molecular weight range from 8,000 g mol-1 to 30,000 g mol-1, these guanidine polycarbonates exhibited broad-spectrum biocidal activity with low toxicity to red blood cells (RBCs)...
November 10, 2017: Biomacromolecules
Carley A Gwin, Emilie Lefevre, Christina L Alito, Claudia K Gunsch
Silver nanoparticles (AgNPs), which are known to act as biocides, are incorporated into medical and consumer products including athletic clothing, stuffed animals, liquid dietary supplements, and more. The increasing use of AgNPs in these products is likely to lead to their entry into both natural and engineered systems, which has the potential to disrupt bacterial processes including those involved in nutrient cycling in wastewater treatment. In the present study, sequencing batch reactors (SBR) mimicking secondary wastewater treatment were operated to determine the effects of AgNPs on the microbial communities contained within activated sludge of wastewater treatment plants (WWTP)...
November 6, 2017: Science of the Total Environment
J Jutkina, N P Marathe, C-F Flach, D G J Larsson
There is a rising concern that antibiotics, and possibly other antimicrobial agents, can promote horizontal transfer of antibiotic resistance genes. For most types of antimicrobials their ability to induce conjugation below minimal inhibitory concentrations (MICs) is still unknown. Our aim was therefore to explore the potential of commonly used antibiotics and antibacterial biocides to induce horizontal transfer of antibiotic resistance. Effects of a wide range of sub-MIC concentrations of the antibiotics cefotaxime, ciprofloxacin, gentamicin, erythromycin, sulfamethoxazole, trimethoprim and the antibacterial biocides chlorhexidine digluconate, hexadecyltrimethylammoniumchloride and triclosan were investigated using a previously optimized culture-based assay with a complex bacterial community as a donor of mobile resistance elements and a traceable Escherichia coli strain as a recipient...
November 4, 2017: Science of the Total Environment
Eun-Jung Park, Sanghwa Kim, Jaerak Chang
Methylisothiazolinone (MIT) is a powerful biocide and preservative, which is widely used alone or in a 1:3 ratio with methylchloroisothiazolinone (MCIT) under the trade name of Kathons in the manufacture of numerous personal and household products. Considering that Kathons injected intravenously is distributed in the blood and then in the liver, we explored the toxic mechanism of MIT on human liver epithelium cells. At 24 h after exposure, MIT bound to the plasma membrane and the inner wall of vacuoles in the cells, and rupture of the cell membrane and nuclear envelop, autophagosome-like vacuoles formation and mitochondrial damage were observed...
November 7, 2017: Environmental Toxicology
Marcelo Augusto de Souza Costa, Bianca Carreiro Cerri, Sandra Regina Ceccato-Antonini
Fermentation is one of the most critical steps of the fuel ethanol production and it is directly influenced by the fermentation system, selected yeast, and bacterial contamination, especially from the genus Lactobacillus. To control the contamination, the industry applies antibiotics and biocides; however, these substances can result in an increased cost and environmental problems. The use of the acid treatment of cells (water-diluted sulfuric acid, adjusted to pH 2.0-2.5) between the fermentation cycles is not always effective to combat the bacterial contamination...
November 6, 2017: Letters in Applied Microbiology
Sanye Soroldoni, Samantha Eslava Martins, Italo Braga Castro, Grasiela Lopes Leães Pinho
Antifouling paint particles (APPs) are residues generated during maintenance of vessels. In boat maintenance areas of South America, waste generation and disposal are not completely regulated. Therefore, APPs can enter into the aquatic environment and act as a source of contamination by metals and other biocides. Thus, the aim of the present study was to evaluate the potential ecotoxicity of the metal mixture present in APPs leached under different salinities. Therefore, the copepod Acartia tonsa was exposed to different concentrations of a leachate solution prepared by the addition of APPs (1...
November 2, 2017: Ecotoxicology and Environmental Safety
Giulia Germinario, Silvia Garrappa, Valeria D'Ambrosio, Inez Dorothé van der Werf, Luigia Sabbatini
Felt-tip pens are frequently used for the realization of sketches, drawings, architectural projects, and other technical designs. The formulations of these inks are usually rather complex and may be associated to those of modern paint materials where, next to the binding medium and pigments/dyes, solvents, fillers, emulsifiers, antioxidants, plasticizers, light stabilizers, biocides, and so on are commonly added. Felt-tip pen inks are extremely sensitive to degradation and especially exposure to light may cause chromatic changes and fading...
November 2, 2017: Analytical and Bioanalytical Chemistry
Eoin Ó Muimhneacháin, F Jerry Reen, Fergal O'Gara, Gerard P McGlacken
The emergence of antibiotic resistance coupled with the lack of investment by pharmaceutical companies necessitates a new look at how we tackle bacterial infections. An intriguing tactic is the interruption of bacterial communication systems. This non-biocidal approach would circumvent the evolutionary pressure on bacteria to mutate and develop resistance. In many pathogenic microorganisms, communication systems, collectively termed quorum sensing (QS), have been observed to control a number of bacterial behaviours including expression of virulence factors and the development of biofilms...
November 2, 2017: Organic & Biomolecular Chemistry
Mark A Webber, Michelle M C Buckner, Liam S Redgrave, Gyles Ifill, Lesley A Mitchenall, Carly Webb, Robyn Iddles, Anthony Maxwell, Laura J V Piddock
Objectives: Cross-resistance between antibiotics and biocides is a potentially important driver of MDR. A relationship between susceptibility of Salmonella to quinolones and triclosan has been observed. This study aimed to: (i) investigate the mechanism underpinning this; (ii) determine whether the phenotype is conserved in Escherichia coli; and (iii) evaluate the potential for triclosan to select for quinolone resistance. Methods: WT E. coli, Salmonella enterica serovar Typhimurium and gyrA mutants were used...
October 1, 2017: Journal of Antimicrobial Chemotherapy
Hee-Seok Lee, Eun-Jung Park, Songyi Han, Gyeong-Yong Oh, Hui-Seung Kang, Jin-Hyang Suh, Min-Ki Shin, Hyun-Suk Oh, Myung-Sil Hwang, Guiim Moon, Young-Ho Koh, Yooheon Park, Jin-Hwan Hong, Yong Eui Koo
The aim of this study is to assess the androgen receptor (AR) agonistic/antagonistic effects on various chemicals, which are used in household products including cleaning agents and wetted tissues by in vitro OECD test guideline No. 458 (using AR-EcoScreen™ cell line) and the me-too test method (using 22Rv1cell line), which was adopted as OECD project No. 4.99. All chemicals were not determined as AR agonists. However α-dodecyl-ω-hydroxypoly (oxyethylene) and 3-iodo-2-propynyl butylcarbamate have shown a weak AR antagonistic effects with IC50 values of 2...
October 14, 2017: Chemosphere
Alexandre Bergé, Laure Wiest, Robert Baudot, Barbara Giroud, Emmanuelle Vulliet
Healthcare facility discharges, by their nature, are often considered as non-domestic effluent, which can provide significant pollution comparatively to other domestic sources. In this context, a total of 12 monthly sampling campaigns were collected from a healthcare facility as well as the output of a sewerage system of Site Pilote de Bellecombe (SIPIBEL) observatory. This study focuses more specifically on 12 surfactants and biocides: four anionics, four cationic, two non-ionic, one zwitterionic, and one dispersive agent, among the most commonly used commercial surfactants...
October 23, 2017: Environmental Science and Pollution Research International
Carmine J Slipski, George G Zhanel, Denice C Bay
Bacterial resistance to biocides used as antiseptics, dyes, and disinfectants is a growing concern in food preparation, agricultural, consumer manufacturing, and health care industries, particularly among Gram-negative Enterobacteriaceae, some of the most common community and healthcare-acquired bacterial pathogens. Biocide resistance is frequently associated with antimicrobial cross-resistance leading to reduced activity and efficacy of both antimicrobials and antiseptics. Multidrug resistant efflux pumps represent an important biocide resistance mechanism in Enterobacteriaceae...
October 23, 2017: Journal of Membrane Biology
Tripti Thapa Gupta, Surya B Karki, Jyl S Matson, Daniel J Gehling, Halim Ayan
Nosocomial infections caused by opportunistic bacteria pose major healthcare problem worldwide. Out of the many microorganisms responsible for such infections, Pseudomonas aeruginosa is a ubiquitous bacterium that accounts for 10-20% of hospital-acquired infections. These infections have mortality rates ranging from 18 to 60% and the cost of treatment ranges from $20,000 to $80,000 per infection. The formation of biofilms on medical devices and implants is responsible for the majority of those infections. Only limited progress has been made to prevent this issue in a safe and cost-effective manner...
2017: BioMed Research International
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