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https://www.readbyqxmd.com/read/28646102/tips-for-publishing-your-clinical-cardiology-research
#1
Catherine M Otto
No abstract text is available yet for this article.
June 23, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28642940/mass-spectrometry-imaging-for-clinical-research-latest-developments-applications-and-current-limitations
#2
REVIEW
Pierre-Maxence Vaysse, Ron M A Heeren, Tiffany Porta, Benjamin Balluff
Mass spectrometry is being used in many clinical research areas ranging from toxicology to personalized medicine. Of all the mass spectrometry techniques, mass spectrometry imaging (MSI), in particular, has continuously grown towards clinical acceptance. Significant technological and methodological improvements have contributed to enhance the performance of MSI recently, pushing the limits of throughput, spatial resolution, and sensitivity. This has stimulated the spread of MSI usage across various biomedical research areas such as oncology, neurological disorders, cardiology, and rheumatology, just to name a few...
June 23, 2017: Analyst
https://www.readbyqxmd.com/read/28639183/proprotein-convertase-subtilisin-kexin-type-9-pcsk9-and-its-inhibitors-a-review-of-physiology-biology-and-clinical-data
#3
REVIEW
Ashwin Durairaj, Alberto Sabates, Jonathan Nieves, Brian Moraes, Seth Baum
Atherosclerotic cardiovascular disease (ASCVD) remains the number one killer in the western world. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and ezetimibe has been shown to reduce the risk of cardiovascular events. Now, proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies (mabs) are available for high-risk individuals with ASCVD or familial hypercholesterolemia on maximally tolerated statin therapy but requiring greater LDL-C reduction. PCSK9 mab outcome trial results from the Further Cardiovascular Outcomes Research with PCSK9 Inhibitions in Subjects with Elevated Risk (FOURIER) study, which was presented at the American College of Cardiology in March 2017, which demonstrated a decrease of 15% in primary and 20% secondary end points over a 2-year period [1••]...
August 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28630370/evidence-for-therapeutic-patient-education-interventions-to-promote-cardiovascular-patient-self-management-a-scientific-statement-for-healthcare-professionals-from-the-american-heart-association
#4
REVIEW
Susan Barnason, Connie White-Williams, Laura P Rossi, Mae Centeno, Deborah L Crabbe, Kyoung Suk Lee, Nancy McCabe, Julie Nauser, Paula Schulz, Kelly Stamp, Kathryn Wood
BACKGROUND: The burden of cardiovascular disease as a chronic illness increasingly requires patients to assume more responsibility for their self-management. Patient education is believed to be an essential component of cardiovascular care; however, there is limited evidence about specific therapeutic patient education approaches used and the impact on patient self-management outcomes. METHODS AND RESULTS: An integrative review of the literature was conducted to critically analyze published research studies of therapeutic patient education for self-management in selected cardiovascular conditions...
June 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28621180/interview-with-derek-connolly
#5
Derek Leslie Connolly
Dr Derek Connolly speaks to Adam Price-Evans, Commissioning Editor of Future Cardiology: Derek Leslie Connolly is a Consultant Interventional Cardiologist at Birmingham City Hospital (UK). He qualified from the University of Edinburgh (UK) summa cum laude in Pharmacology in 1985 and in Medicine in 1988 where he was the Brunton Medalist. As a Carnegie scholar at the University of California San Diego (CA, USA) he saw the early promise of angioplasty and changed his career plan from cardiac surgery to coronary intervention...
June 16, 2017: Future Cardiology
https://www.readbyqxmd.com/read/28610621/exploration-of-the-methodological-quality-and-clinical-usefulness-of-a-cross-sectional-sample-of-published-guidance-about-exercise-training-and-physical-activity-for-the-secondary-prevention-of-coronary-heart-disease
#6
Bridget Abell, Paul Glasziou, Tammy Hoffmann
BACKGROUND: Clinicians are encouraged to use guidelines to assist in providing evidence-based secondary prevention to patients with coronary heart disease. However, the expanding number of publications providing guidance about exercise training may confuse cardiac rehabilitation clinicians. We therefore sought to explore the number, scope, publication characteristics, methodological quality, and clinical usefulness of published exercise-based cardiac rehabilitation guidance. METHODS: We included publications recommending physical activity, exercise or cardiac rehabilitation for patients with coronary heart disease...
June 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28596069/validation-of-the-effect-questionnaire-for-competence-based-clinical-teaching-in-residency-training-in-lithuania
#7
Eglė Vaižgėlienė, Žilvinas Padaiga, Daiva Rastenytė, Algimantas Tamelis, Kęstutis Petrikonis, Rima Kregždytė, Cornelia Fluit
BACKGROUND AND AIM: In 2013, all residency programs at the Lithuanian University of Health Sciences were renewed into a competency-based medical education curriculum. To assess the quality of clinical teaching in residency training, we chose the EFFECT (evaluation and feedback for effective clinical teaching) questionnaire designed and validated at the Radboud University Medical Centre in the Netherlands. The aim of this study was to validate the EFFECT questionnaire for quality assessment of clinical teaching in residency training...
May 26, 2017: Medicina
https://www.readbyqxmd.com/read/28593039/is-it-time-for-comprehensive-geriatric-assessment-to-move-beyond-primary-care-the-case-for-targeting-medical-sub-specialty-practice
#8
Laura K Byerly, G Michael Harper
Comprehensive geriatric assessment (CGA) as a consultative service for older adults with complex medical and psychosocial challenges has existed for decades. However, studies have often showed inconsistent acceptance and implementation of geriatric recommendations by primary care providers (PCPs) raising doubts about the overall benefits of CGA in this setting. Press and colleagues investigated the patient- and provider-related factors that affect recommendation implementation, and like previous studies, they too found similarly low rates of implementation...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28589536/distinguishing-pathogenic-mutations-from-background-genetic-noise-in-cardiology-the-use-of-large-genome-databases-for-genetic-interpretation
#9
REVIEW
Jonas Ghouse, Morten W Skov, Robert S Bigseth, Gustav Ahlberg, Jørgen K Kanters, Morten S Olesen
Advances in clinical genetic testing has led to increased insight into the human genome, including how challenging it is to interpret rare genetic variation. In some cases, the ability to detect genetic mutations exceeds the ability to understand their clinical impact, limiting the advantage of these technologies. Obstacles in genomic medicine are many and include: understanding the level of certainty/uncertainty behind pathogenicity determination, the numerous different variant interpretation-guidelines used by clinical laboratories, delivering the certain or uncertain result to the patient, helping patients evaluate medical decisions in light of uncertainty regarding the consequence of the findings...
June 6, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28584585/an-audit-on-the-appropriateness-of-coronary-computed-tomography-angiography-referrals-in-a-tertiary-cardiac-center
#10
Ahmed Ali Alderazi, Mary Lynch
BACKGROUND: In response to growing concerns regarding the overuse of coronary computed tomography angiography (CCTA) in the clinical setting, multiple societies, including the American College of Cardiology Foundation, have jointly published revised criteria regarding the appropriate use of this imaging modality. However, previous research indicates significant discrepancies in the rate of adherence to these guidelines. AIM: To assess the appropriateness of CCTA referrals in a tertiary cardiac center in Bahrain...
January 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/28569545/interview-with-alexander-cohen
#11
Alexander Ander Cohen
Ander Cohen speaks to Adam Price-Evans, Commissioning Editor of Future Cardiology: Alexander (Ander) Cohen MBBS (Hons), MSc, MD, FRACP is a vascular physician and epidemiologist at Guy's and St Thomas' Hospital, King's College (London, UK). He graduated with honors in medicine and honors in surgery from the University of Melbourne, Australia, and became a fellow of the Royal Australasian College of Physicians in 1990. He was awarded an MSc in Epidemiology from the London School of Hygiene and Tropical Medicine, University of London in 1991 with a thesis on the metabolic syndrome in South-Asian populations...
June 1, 2017: Future Cardiology
https://www.readbyqxmd.com/read/28569337/the-assessment-of-the-complexity-of-care-through-the-clinical-nursing-information-system-in-clinical-practice-a-study-protocol
#12
C Bravetti, A Cocchieri, F D'Agostino, R Alvaro, M Zega
BACKGROUND: The costs of nursing staff amounts to approximately 50% of the total budget of the health workforce and accounts for 20% to 30% of the total costs incurred by the health care companies. The goal of the study, by analyzing the complexity of care, is to provide a quantification of the assistance delivered, through the assessment of the technical aspects of the welfare activities according to the variable of time. Data from these activities flow into the clinical nursing information system Professional Assessment Instrument - PAI - which is used at the health facility involved in this study...
July 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28560717/organ-dysfunction-injury-and-failure-in-acute-heart-failure-from-pathophysiology-to-diagnosis-and-management-a-review-on-behalf-of-the-acute-heart-failure-committee-of-the-heart-failure-association-hfa-of-the-european-society-of-cardiology-esc
#13
REVIEW
Veli-Pekka Harjola, Wilfried Mullens, Marek Banaszewski, Johann Bauersachs, Hans-Peter Brunner-La Rocca, Ovidiu Chioncel, Sean P Collins, Wolfram Doehner, Gerasimos S Filippatos, Andreas J Flammer, Valentin Fuhrmann, Mitja Lainscak, Johan Lassus, Matthieu Legrand, Josep Masip, Christian Mueller, Zoltán Papp, John Parissis, Elke Platz, Alain Rudiger, Frank Ruschitzka, Andreas Schäfer, Petar M Seferovic, Hadi Skouri, Mehmet Birhan Yilmaz, Alexandre Mebazaa
Organ injury and impairment are commonly observed in patients with acute heart failure (AHF), and congestion is an essential pathophysiological mechanism of impaired organ function. Congestion is the predominant clinical profile in most patients with AHF; a smaller proportion presents with peripheral hypoperfusion or cardiogenic shock. Hypoperfusion further deteriorates organ function. The injury and dysfunction of target organs (i.e. heart, lungs, kidneys, liver, intestine, brain) in the setting of AHF are associated with increased risk for mortality...
May 30, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28554990/the-role-of-scube1-in-the-pathogenesis-of-no-reflow-phenomenon-presenting-with-st-segment-elevation-myocardial-infarction
#14
Hasan Ata Bolayır, Hakan Güneş, Tarık Kıvrak, Ömer Şahin, Dursun Akaslan, Recep Kurt, Aslı Bolayır, Oya İmadoğlu
OBJECTIVE: SCUBE1 [signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domain-containing protein 1] might function as a novel platelet-endothelial adhesion molecule and play pathological roles in cardiovascular biology. Acute myocardial infarction is one of the most common causes of death in modern society. The concept of "no reflow" (NR) refers to a state of myocardial tissue hypoperfusion in the presence of a patent epicardial coronary artery. The main mechanisms of this phenomenon are thought to be high platelet activity and much thrombus burden...
May 24, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28540209/myocardial-blood-flow-quantification-for-evaluation-of-coronary-artery-disease-by-computed-tomography
#15
REVIEW
Filippo Cademartiri, Sara Seitun, Alberto Clemente, Ludovico La Grutta, Patrizia Toia, Giuseppe Runza, Massimo Midiri, Erica Maffei
During the last decade coronary computed tomography angiography (CTA) has become the preeminent non-invasive imaging modality to detect coronary artery disease (CAD) with high accuracy. However, CTA has a limited value in assessing the hemodynamic significance of a given stenosis due to a modest specificity and positive predictive value. In recent years, different CT techniques for detecting myocardial ischemia have emerged, such as CT-derived fractional flow reserve (FFR-CT), transluminal attenuation gradient (TAG), and myocardial CT perfusion (CTP) imaging...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28537000/advances-in-clinical-cardiology-2016-a-summary-of-the-key-clinical-trials
#16
REVIEW
Alastair Gray, Conor McQuillan, Ian B A Menown
INTRODUCTION: The findings of many new cardiology clinical trials over the last year have been published or presented at major international meetings. This paper aims to describe and place in context a summary of the key clinical trials in cardiology presented between January and December 2016. METHODS: The authors reviewed clinical trials presented at major cardiology conferences during 2016 including the American College of Cardiology (ACC), European Association for Percutaneous Cardiovascular Interventions (EuroPCR), European Society of Cardiology (ESC), European Association for the Study of Diabetes (EASD), Transcatheter Cardiovascular Therapeutics (TCT), and the American Heart Association (AHA)...
May 23, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28511683/acute-coronary-syndrome-patients-admitted-to-a-cardiology-vs-non-cardiology-service-variations-in-treatment-outcome
#17
Deirdre E O'Neill, Danielle A Southern, Colleen M Norris, Blair J O'Neill, Helen J Curran, Michelle M Graham
BACKGROUND: Specialized cardiology services have contributed to reduced mortality in acute coronary syndromes (ACS).  We sought to evaluate the outcomes of ACS patients admitted to non-cardiology services in Southern Alberta. METHODS: Retrospective chart review performed on all troponin-positive patients in the Calgary Health Region identified those diagnosed with ACS by their attending team. Patients admitted to non-cardiology and cardiology services were compared, using linked data from the Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) registry and the Strategic Clinical Network for Cardiovascular Health and Stroke...
May 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28504233/serbia-coronary-and-structural-heart-interventions-from-2010-to-2015
#18
Sinisa Stojkovic, Dejan Milasinovic, Nenad Bozinovic, Aleksandar Davidovic, Dragan Debeljacki, Nemanja Djenic, Sasa Hinic, Nikola Jagic, Olivera Micic, Vladimir Mitov, Aleksandar N Neskovic, Milan Nikolic, Dragan Sagic, Goran Stankovic
Serbia's interventional community has been facing the multifaceted challenge of an ageing population with cardiovascular diseases as the primary cause of death nationwide, coronary artery disease (CAD) being the most prevalent subset. The following two fields of activity have marked the trajectory of progress in the field of interventional cardiology in Serbia: first, the expansion of the infrastructure, mainly through the opening of new catheterisation laboratories across all of the country's administrative regions, which has resulted in better accessibility to coronary interventions for the general population; second, the creation of national platforms for continuous education, training and the promotion of clinical research in interventional cardiology, with close programmatic links to European Association of Percutaneous Cardiovascular Interventions (EAPCI)-based educational initiatives, including the curriculum for interventional cardiology...
May 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28488925/strategies-to-address-the-shortcomings-of-commonly-used-advanced-chronic-heart-failure-descriptors-to-improve-recruitment-in-palliative-care-research-a-parallel-mixed-methods-feasibility-study
#19
Pauline M Kane, Fliss Em Murtagh, Karen R Ryan, Mary Brice, Niall G Mahon, Brendan McAdam, Regina McQuillan, Geraldine O'Gara, Caroline Raleigh, Cecelia Tracey, Christine Howley, Irene J Higginson, Barbara A Daveson
BACKGROUND: Recruitment challenges contribute to the paucity of palliative care research with advanced chronic heart failure patients. AIM: To describe the challenges and outline strategies of recruiting advanced chronic heart failure patients. DESIGN: A feasibility study using a pre-post uncontrolled design. SETTING: Advanced chronic heart failure patients were recruited at two nurse-led chronic heart failure disease management clinics in Ireland Results: Of 372 patients screened, 81 were approached, 38 were recruited (46...
May 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28484914/further-evidence-on-eq-5d-5l-preference-inversion-a-brazil-u-s-collaboration
#20
Benjamin M Craig, Andréa L Monteiro, Michael Herdman, Marisa Santos
PURPOSE: A preference inversion occurs when "worse" health (instead of "better" health) along a scale or score is preferred. Our aim was to confirm past findings of EQ-5D-5L preference inversions among English-speaking respondents and to explore inversions among Portuguese-speaking respondents. Anecdotal evidence suggests that inversions may be more common in the Portuguese version, where the translation of the fourth level "severely" (gravemente) means "gravely." METHODS: Through an infusion clinic in Tampa, Florida, United States and a cardiology clinic in Rio de Janeiro, Brazil, 740 respondents completed a tablet-based survey, which included the EQ-5D-3L and -5L followed by paired comparisons designed to assess preference inversions between the fourth and fifth levels of each of the five domains: Mobility (MO), Self-Care (SC), Usual Activity (UA), Pain/Discomfort (PD), and Anxiety/Depression (AD)...
May 8, 2017: Quality of Life Research
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