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AllergoOncology

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https://www.readbyqxmd.com/read/28526623/allergooncology-ige-and-igg4-mediated-immune-mechanisms-linking-allergy-with-cancer-and-their-translational-implications
#1
EDITORIAL
Erika Jensen-Jarolim, Michelle C Turner, Sophia N Karagiannis
No abstract text is available yet for this article.
May 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28032353/allergooncology-the-impact-of-allergy-in-oncology-eaaci-position-paper
#2
E Jensen-Jarolim, H J Bax, R Bianchini, M Capron, C Corrigan, M Castells, D Dombrowicz, T R Daniels-Wells, J Fazekas, E Fiebiger, S Gatault, H J Gould, J Janda, D H Josephs, P Karagiannis, F Levi-Schaffer, A Meshcheryakova, D Mechtcheriakova, Y Mekori, F Mungenast, E A Nigro, M L Penichet, F Redegeld, L Saul, J Singer, J F Spicer, A G Siccardi, E Spillner, M C Turner, E Untersmayr, L Vangelista, S N Karagiannis
Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments...
June 2017: Allergy
https://www.readbyqxmd.com/read/25110717/tgf-%C3%AE-an-important-mediator-of-allergic-disease-and-a-molecule-with-dual-activity-in-cancer-development
#3
REVIEW
Belen Tirado-Rodriguez, Enrique Ortega, Patricia Segura-Medina, Sara Huerta-Yepez
The transforming growth factor- β (TGF- β ) superfamily is a family of structurally related proteins that includes TGF- β , activins/inhibins, and bone morphogenic proteins (BMPs). Members of the TGF- β superfamily regulate cellular functions such as proliferation, apoptosis, differentiation, and migration and thus play key roles in organismal development. TGF- β is involved in several human diseases, including autoimmune disorders and vascular diseases. Activation of the TGF- β receptor induces phosphorylation of serine/threonine residues and triggers phosphorylation of intracellular effectors (Smads)...
2014: Journal of Immunology Research
https://www.readbyqxmd.com/read/24117861/ige-based-immunotherapy-of-cancer-challenges-and-chances
#4
REVIEW
J Singer, E Jensen-Jarolim
Passive immunotherapy with monoclonal antibodies is an indispensable cornerstone of clinical oncology. Notably, all FDA-approved antibodies comprise the IgG class, although numerous research articles proposed monoclonal antibodies of the IgM, IgG, IgA and IgE classes directed specifically against tumor-associated antigens. In particular, for the IgE isotype class, several recent studies could demonstrate high tumoricidic efficacy. Therefore, this review specifically highlights the latest developments toward IgE-based immunotherapy of cancer...
February 2014: Allergy
https://www.readbyqxmd.com/read/22911119/the-nascent-field-of-allergooncology
#5
EDITORIAL
Erika Jensen-Jarolim, Graham Pawelec
Many intriguing relationships between allergy and cancer continue to pose important unanswered questions. Is there a correlation between IgE and atopy, and cancer? Which are the most important IgE effector cells and do they inhibit or promote tumor growth? Will IgE-mediated antigen uptake and cross-presentation by DCs activate CTLs or Tregs? What animal models are useful in this context and should we design specific anti-tumor immunotherapies, active or passive, based on IgE? Recombinant IgE has already been generated against the tumor-associated antigens folate-binding receptor, HER-2 and EGFR--how to exclude the risk of anaphylaxis in passive immunotherapy with IgE? How can we deal with hypersensitivity to antineoplastic drugs? What is the role of chemotherapeutics and biologicals in the modulation of IgE responses and the impact of the aberrant expression of mutated enzyme AID in cancer tissue? In an effort to survey the state-of-the-art in this area and to answer some of these questions, we invited leaders in the field to participate in a "Symposium-in-Writing"...
September 2012: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/18671772/allergooncology-the-role-of-ige-mediated-allergy-in-cancer
#6
REVIEW
E Jensen-Jarolim, G Achatz, M C Turner, S Karagiannis, F Legrand, M Capron, M L Penichet, J A Rodríguez, A G Siccardi, L Vangelista, A B Riemer, H Gould
Epidemiological studies have suggested inverse associations between allergic diseases and malignancies. As a proof of concept for the capability of immunoglobulin E (IgE) to destruct tumor cells, several experimental strategies have evolved to specifically target this antibody class towards relevant tumor antigens. It could be demonstrated that IgE antibodies specific to overexpressed tumor antigens have been superior to any other immunoglobulin class with respect to antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) reactions...
October 2008: Allergy
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