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https://www.readbyqxmd.com/read/28730109/human-eye-ocular-component-analysis-for-refractive-state-and-refractive-surgery
#1
Chao-Kai Chang, Jui-Teng Lin, Yong Zhang
AIM: To analyze the clinical factors influencing the human vision corrections via the changing of ocular components of human eye in various applications; and to analyze refractive state via a new effective axial length. METHODS: An effective eye model was introduced by the ocular components of human eye including refractive indexes, surface radius (r1, r2, R1, R2) and thickness (t, T) of the cornea and lens, the anterior chamber depth (S1) and the vitreous length (S2)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28727706/opioids-for-ocular-pain-a-narrative-review
#2
Vinicius Bp Pereira, Renato Garcia, Andre Am Torricelli, Samir J Bechara
BACKGROUND: Refractive surgery is a common procedure, but may be associated with severe post-operative pain. OBJECTIVES: To describe studies addressing the use of opioids for control of pain after ocular surgery, with an emphasis on refractive surgery. STUDY DESIGN: This is a narrative review of relevant articles on the physiology of corneal pain and the use of opioids for its treatment after surgery. SETTING: Single tertiary center...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28726355/combined-cataract-dsek-dmek-changing-expectations
#3
Francis W Price, Marianne O Price
Endothelial keratoplasty (EK) has revolutionized corneal transplant surgery by providing rapid visual recovery and improved visual outcomes. In parts of the world with Fuchs endothelial dystrophy, many patients may present with both cataracts and corneal degeneration requiring surgery. Other forms of endothelial decompensation may also present with cataracts. The staging or combination of transplant surgery and cataract surgery depend on both the abilities of the surgeon and the surgical techniques being considered...
July 18, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28721004/epithelium-on-photorefractive-intrastromal-cross-linking-pixl-for-reduction-of-low-myopia
#4
Wee Kiak Lim, Zhi Da Soh, Harold Kah Yen Choi, Julian Thiam Siew Theng
PURPOSE: To report the 9-12-month outcomes of a novel procedure for reduction of low myopia through epithelium-on photorefractive intrastromal cross-linking (PiXL) with customized control of topographic distribution of ultraviolet (UV)-fluence. METHOD: Myopic patients with normal (non-ectatic) corneas underwent the PiXL procedure for reduction of low myopia. PiXL treatments were delivered through selective application of UVA light based on the refractive error of each patient...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28708898/retreatment-strategies-following-small-incision-lenticule-extraction-smile-in-vivo-tissue-responses
#5
Andri K Riau, Yu-Chi Liu, Chris H L Lim, Nyein C Lwin, Ericia P Teo, Gary H Yam, Donald T Tan, Jodhbir S Mehta
With any refractive correction, including Small Incision Lenticule Extraction (SMILE), there may be a residual refractive error that requires a retreatment. Here, we investigated the tissue responses following various retreatment procedures in a rabbit model of SMILE. All rabbits underwent a -6.00D correction with SMILE. Two weeks later, they underwent -1.00D enhancement by: (i) VisuMax Circle, followed by excimer ablation (S+C); (ii) secondary SMILE anterior to the primary procedure (S+SE); or (iii) surface ablation (S+P), and were examined for 28 days...
2017: PloS One
https://www.readbyqxmd.com/read/28707599/designing-of-selective-%C3%AE-secretase-inhibitory-benzenesulfonamides-through-comparative-in-vitro-and-in-silico-analysis
#6
Neeraj Masand, Satya P Gupta, Ratan Lal Khosa
BACKGROUND: In Alzheimer's disease (AD), the gene mutations have been identified in the amyloid precursor protein (APP), the presenilin-1 (PS1) and -2 (PS2) genes. APP is a transmembrane protein which gets cleaved by α- and β-secretase enzymes and releases Aβ peptides which forms senile plaques in brain tissue. It contributes for local inflammatory response, subsequent oxidative stress, biochemical changes and neuronal death. Targeting the development of Aβ aggregates in the senile plaques is an important strategy in the treatment of AD...
July 13, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28700146/in-vivo-thz-imaging-of-human-skin-accounting-for-occlusion-effects
#7
Qiushuo Sun, Edward P J Parrott, Yuezhi He, Emma Pickwell-Macpherson
In vivo terahertz (THz) imaging of human skin needs to be done in reflection geometry due to the high attenuation of THz light by water in the skin. To aid the measurement procedure, there is typically an imaging window onto which the patient places the area of interest. The window enables better pulse alignment and helps keep the patient correctly positioned during the measurement. In this paper we demonstrate how the occlusion caused by the skin contact with the imaging window during the measurement affects the THz response...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28700139/oct-layered-tomography-of-the-cornea-provides-new-insights-on-remodeling-after-photorefractive-keratectomy
#8
Rachana S Chandapura, Rohit Shetty, Rushad Shroff, Neha Shilpy, Mathew Francis, Abhijit Sinha Roy
OCT topography of corneal layers was generated to analyze the remodeling of the epithelium and stroma after photorefractive keratectomy (PRK). Myopic PRK was performed in 15 patients. One eye underwent manual scraping of epithelium while the other was treated with Epi clear™. Epi clear allowed a gentler removal of the epithelium compared to manual scraping. Scheimpflug (Pentacam™, OCULUS Optikgerate Gmbh, Germany) and OCT (RTVue™, Optovue Inc., USA) scan of the cornea was performed before and after PRK (3 months)...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28696826/a-comparative-study-on-surgical-outcomes-of-glued-intraocular-lens-and-sutured-scleral-fixated-intraocular-lens-implantation
#9
Divya Balakrishnan, Vinod Mukundaprasad, Subhadra Jalali, Rajeev Reddy Pappuru
PURPOSE: To compare the surgical outcomes of glued intraocular lens (GIOL) and sutured scleral fixated intraocular lens (SFIOL) implantation. METHODS: A retrospective, interventional case series of 60 patients (68 eyes) who underwent GIOL (28 eyes: 11 primary; 17 secondary) and SFIOL (40 eyes: 24 primary; 16 secondary) in a tertiary eye care institute was done. The main outcome measures were complications, time taken for surgery, postoperative refractive outcomes, and final best-corrected visual acuity (BCVA)...
July 11, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28690535/femtosecond-laser-in-situ-keratomileusis-flap-creation-in-narrow-palpebral-fissure-eyes-without-suction
#10
John S M Chang, Antony K P Law, Jack C M Ng, May S Y Cheng
PURPOSE: To evaluate a surgical technique used in eyes with narrow palpebral fissure undergoing femtosecond laser flap creation without suction during laser in situ keratomileusis (LASIK). METHODS: All data of 2 patient groups were collected through chart review. Group 1 consisted of 6 eyes with narrow palpebral fissure in which the suction ring was manually fixated and femtosecond laser was applied accordingly. Thirty comparison cases were randomly drawn from among eyes that underwent a standard LASIK procedure matched for age and preoperative refraction (group 2)...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28683485/-therapeutic-options-in-keratoconus
#11
Frederik Raiskup, Janine Lenk, Robert Herber, Zisis Gatzioufas, Eberhard Spörl
A recent epidemiology study revealed that prevalence of keratoconus was much higher than previously assumed. Therefore, it is no longer deemed an "orphan disease", as it has a relevant socioeconomic impact on the healthcare system. One of the most important risk factors for developing keratoconus is chronic eye rubbing which, apart from other known risk factors such as atopy or Down's syndrome, is the only modifiable factor. Informing the patient and offering behavior modifying therapies seems to be essential...
July 6, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28681906/refractive-changes-induced-by-spherical-aberration-in-laser-correction-procedures-an-adaptive-optics-study
#12
Alfredo Amigó, Paula Martinez-Sorribes, Margarita Recuerda
PURPOSE: To study the effect on vision of induced negative and positive spherical aberration within the range of laser vision correction procedures. METHODS: In 10 eyes (mean age: 35.8 years) under cyclopegic conditions, spherical aberration values from -0.75 to +0.75 µm in 0.25-µm steps were induced by an adaptive optics system. Astigmatism and spherical refraction were corrected, whereas the other natural aberrations remained untouched. Visual acuity, depth of focus defined as the interval of vision for which the target was still perceived acceptable, contrast sensitivity, and change in spherical refraction associated with the variation in pupil diameter from 6 to 2...
July 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28681903/contralateral-eye-comparison-of-smile-and-flap-based-corneal-refractive-surgery-computational-analysis-of-biomechanical-impact
#13
Ibrahim Seven, Ali Vahdati, Iben Bach Pedersen, Anders Vestergaard, Jesper Hjortdal, Cynthia J Roberts, William J Dupps
PURPOSE: Computational analyses were performed to quantify and directly compare the biomechanical impact of flapless and flap-based procedures in a series of patients undergoing small incision lenticule extraction (SMILE) in one eye and flap-based femtosecond lenticule extraction in the other. METHODS: Tomographic data from 10 eyes of 5 patients undergoing femtosecond laser refractive lenticule extraction for myopic astigmatism with or without a stromal flap (femtosecond lenticule extraction in one eye, SMILE in the contralateral eye) were used to generate computational models...
July 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28674958/monovision-versus-multifocality-for-presbyopia-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
REVIEW
Lidija Kelava, Hrvoje Barić, Mladen Bušić, Ivan Čima, Vladimir Trkulja
INTRODUCTION: Refractive surgery in presbyopia tends to achieve spectacle independence with minimal optical disturbances. We compared monovision to multifocality procedures regarding these outcomes. METHODS: We conducted a systematic review of published (till November 21, 2016) randomized controlled trials (RCTs) comparing any monovision to any multifocality method or comparing different monovision/multifocality methods to each other that enabled direct or indirect comparisons between particular monovision and particular multifocality procedures in presbyopic patients undergoing cataract-related or unrelated surgery in respect to spectacle independence, unaided binocular visual acuity (VA), contrast sensitivity (CS), and adverse events...
July 3, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28671403/refractive-eye-surgery-helping-patients-make-informed-decisions-about-lasik
#15
John M Wilkinson, Elizabeth W Cozine, Amir R Kahn
A variety of refractive surgery techniques, which reshape the corneal stroma using laser energy, have been marketed as simple and safe alternatives to glasses or contact lenses. Laser-assisted in-situ keratomileusis (LASIK) is the most common of these procedures. Although there are few high-quality prospective studies of long-term outcomes, complications, or stability for refractive surgery procedures, there is at least general agreement that more than 90% of appropriately selected patients achieve excellent uncorrected distance vision...
May 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28655729/corneal-collagen-cross-linking-in-paediatric-patients-affected-by-keratoconus
#16
Karl Anders Knutsson, Giorgio Paganoni, Stanislav Matuska, Oriella Ambrosio, Giulio Ferrari, Arianna Zennato, Michela Caccia, Paolo Rama
BACKGROUND/AIMS: To evaluate the effectiveness of corneal collagen cross-linking (CXL) in paediatric patients. METHODS: Fifty-two eyes of 43 paediatric patients with progressive keratoconus were enrolled in a prospective cohort study. Corneal CXL was performed using a conventional technique with instillation of 0.1% riboflavin solution containing dextran 20% for 30 min during the soaking phase and during the 30 min ultraviolet A irradiation (3 mW/cm(2)). Visual outcomes, topographic keratometry, maximum keratometry (K-max), refractive astigmatism, demarcation line and endothelial cell density were measured postoperatively...
June 27, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28655538/u-s-multicenter-clinical-trial-of-corneal-collagen-crosslinking-for-treatment-of-corneal-ectasia-after-refractive-surgery
#17
Peter S Hersh, R Doyle Stulting, David Muller, Daniel S Durrie, Rajesh K Rajpal
PURPOSE: To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of corneal ectasia after laser refractive surgery. DESIGN: Prospective, randomized, multicenter, controlled clinical trial. PARTICIPANTS: One hundred seventy-nine subjects with corneal ectasia after previous refractive surgery. METHODS: The treatment group underwent standard CXL, and the sham control group received riboflavin alone without removal of the epithelium...
June 24, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28624326/randomized-trial-on-illuminated-microcatheter-circumferential-trabeculotomy-versus-conventional-trabeculotomy-in-congenital-glaucoma
#18
Jyoti Shakrawal, Shveta Bali, Talvir Sidhu, Saurabh Verma, Ramanjit Sihota, Tanuj Dada
PURPOSE: To compare one year outcomes of illuminated microcatheter-assisted circumferential trabeculotomy(IMCT) vs conventional partial trabeculotomy(CPT) for Primary Congenital Glaucom (PCG). DESIGN: Randomized clinical trial METHODS: Forty eyes of 31 patients with unilateral or bilateral primary congenital glaucoma aged less than two years were randomized to undergo IMCT (20 eyes) or CPT (20 eyes). Primary outcome measure was IOP reduction. The success criterion was defined as intraocular pressure (IOP) ≤ 12 mm Hg without and with anti-glaucoma medications (absolute success and qualified success respectively)...
June 14, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28624312/non-lens-based-surgical-techniques-for-presbyopia-correction
#19
R Bilbao-Calabuig, F Llovet-Osuna
INTRODUCTION: Presbyopia is the most prevalent refractive error. With a progressive aging population, its surgical correction is an important challenge for the ophthalmology community, as well as the millions of patients who suffer from it, and who are increasingly demanding alternatives to its correction with glasses or contact lenses. MATERIAL AND METHODS: A review is presented with a synthesised discussion on the pathophysiological theories of presbyopia and an updated and analytical description of the non-lens involvement surgical techniques used to treat presbyopia...
June 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28622316/corneal-densitometry-after-photorefractive-keratectomy-laser-assisted-in-situ-keratomileusis-and-small-incision-lenticule-extraction
#20
F Poyales, N Garzón, J Mendicute, I Illarramendi, P Caro, O Jáñez, F Argüeso, A López
PurposeThe aim of this study was to gain greater insight into the corneal densitometry changes occurring as a result of refractive surgery and to compare these changes across three widely used surgical techniques, namely, photorefractive keratectomy (PRK), laser-assisted in situ keratomileusis with a femtosecond laser (LASIK-FS), or ReLEx small-incision lenticule extraction (ReLEx SMILE).Patients and methodsThree hundred and thirty-six patients (184 male and 152 female patients) participated in this study. They were split into three groups according to the refractive surgery technique they had undergone: LASIK-FS (74 patients), PRK (153 patients), and ReLEx SMILE (109 patients)...
June 16, 2017: Eye
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