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fMRI swallowing

Erin Kamarunas, Rachel Mulheren, Katie Palmore, Christy Ludlow
Saliva accumulation in the oropharynx generates an automatic pattern of swallowing in the brainstem in animals. Previous fMRI studies have found that spontaneous saliva and water swallows in humans evoked activation following swallow onset in both precentral motor and postcentral somatosensory cortical regions. Using event-related averaging of continuous functional near infrared spectroscopy (fNIRS), we examined cortical hemodynamic responses (HDR) from 5 s before to 35 s after spontaneous reflexive saliva swallow onset in the lateral postcentral somatosensory and precentral motor regions in both hemispheres in healthy volunteers...
February 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Francisca M Tan, César Caballero-Gaudes, Karen J Mullinger, Siu-Yeung Cho, Yaping Zhang, Ian L Dryden, Susan T Francis, Penny A Gowland
Most functional MRI (fMRI) studies map task-driven brain activity using a block or event-related paradigm. Sparse paradigm free mapping (SPFM) can detect the onset and spatial distribution of BOLD events in the brain without prior timing information, but relating the detected events to brain function remains a challenge. In this study, we developed a decoding method for SPFM using a coordinate-based meta-analysis method of activation likelihood estimation (ALE). We defined meta-maps of statistically significant ALE values that correspond to types of events and calculated a summation overlap between the normalized meta-maps and SPFM maps...
November 2017: Human Brain Mapping
Jillian A Toogood, Rebecca C Smith, Todd K Stevens, Joe S Gati, Ravi S Menon, Julie Theurer, Sarah Weisz, Rebecca H Affoo, Ruth E Martin
The present study sought to elucidate the functional contributions of sub-regions of the swallowing neural network in swallowing preparation and swallowing motor execution. Seven healthy volunteers participated in a delayed-response, go, no-go functional magnetic resonance imaging study involving four semi-randomly ordered activation tasks: (i) "prepare to swallow," (ii) "voluntary saliva swallow," (iii) "do not prepare to swallow," and (iv) "do not swallow." Results indicated that brain activation was significantly greater during swallowing preparation, than during swallowing execution, within the rostral and intermediate anterior cingulate cortex bilaterally, premotor cortex (left > right hemisphere), pericentral cortex (left > right hemisphere), and within several subcortical nuclei including the bilateral thalamus, caudate, and putamen...
August 2017: Dysphagia
Paul Glad Mihai, Mareile Otto, Martin Domin, Thomas Platz, Shaheen Hamdy, Martin Lotze
Neurogenic dysphagia frequently occurs after stroke and deglutitive aspiration is one of the main reasons for subacute death after stroke. Although promising therapeutic interventions for neurogenic dysphagia are being developed, the functional neuroanatomy of recovered swallowing in this population remains uncertain. Here, we investigated 18 patients post-stroke who recovered from dysphagia using an event related functional magnetic resonance imaging (fMRI) study of swallowing. Patients were characterized by initial dysphagia score (mild to severe), lesion mapping, white matter fractional anisotropy (FA) of the pyramidal tracts, and swallowing performance measurement during fMRI scanning...
2016: NeuroImage: Clinical
Pascal Saker, Michael J Farrell, Gary F Egan, Michael J McKinley, Derek A Denton
In humans, drinking replenishes fluid loss and satiates the sensation of thirst that accompanies dehydration. Typically, the volume of water drunk in response to thirst matches the deficit. Exactly how this accurate metering is achieved is unknown; recent evidence implicates swallowing inhibition as a potential factor. Using fMRI, this study investigated whether swallowing inhibition is present after more water has been drunk than is necessary to restore fluid balance within the body. This proposal was tested using ratings of swallowing effort and measuring regional brain responses as participants prepared to swallow small volumes of liquid while they were thirsty and after they had overdrunk...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
Maíra Santilli de Lima, Laura Davison Mangilli, Fernanda Chiarion Sassi, Claudia Regina Furquim de Andrade
INTRODUCTION: Aspects of the neuroanatomical representation of swallowing have been investigated in humans through brain mapping techniques, such as functional magnetic resonance imaging (fMRI). OBJECTIVE: This critical qualitative review of the literature analyzed international scientific publications in the PubMed database that investigated the activation of the central nervous system in humans during the act of swallowing. METHODS: This investigation was limited to articles that investigated adults older than 18 years, published in English or Portuguese, between January 2002 and December 2013...
November 2015: Brazilian Journal of Otorhinolaryngology
Emilia Michou, Steve Williams, Rishma Vidyasagar, Darragh Downey, Satish Mistry, Richard A E Edden, Shaheen Hamdy
INTRODUCTION: Paired associative stimulation (PAS), is a novel non-invasive technique where two neural substrates are employed in a temporally coordinated manner in order to modulate cortico-motor excitability within the motor cortex (M1). In swallowing, combined pharyngeal electrical and transcranial-magnetic-stimulation induced beneficial neurophysiological and behavioural effects in healthy subjects and dysphagic stroke patients. Here, we aimed to investigate the whole-brain changes in neural activation during swallowing using functional magnetic resonance imaging (fMRI) following PAS application and in parallel assess associated GABA changes with magnetic resonance spectroscopy (MRS)...
August 15, 2015: NeuroImage
Anne-Sophie Windel, Paul Glad Mihai, Martin Lotze
We investigated the neural representation of swallowing in two age groups for a total of 51 healthy participants (seniors: average age 64 years; young adults: average age 24 years) using high spatial resolution functional magnetic resonance imaging (fMRI). Two statistical comparisons (classical and Bayesian inference) revealed no significant differences between subject groups, apart from higher cortical activation for the seniors in the frontal pole 1 of Brodmann's Area 10 using Bayesian inference. Seniors vs...
June 1, 2015: Behavioural Brain Research
Catherine F Sinclair, Kristina Simonyan, Mitchell F Brin, Andrew Blitzer
OBJECTIVE: To present the first documented series of patients with negative dystonia (ND) of the palate, including clinical symptoms, functional MRI findings, and management options. STUDY DESIGN: Case series ascertained from clinical research centers that evaluated patients with both hyperkinetic and hypokinetic movement disorders. METHODS: Between July 1983 and March 2013, data was collected on patient demographics, disease characteristics, functional MRI findings, long-term management options, and outcomes...
June 2015: Laryngoscope
Andrea Ruggieri, Anna Elisabetta Vaudano, Francesca Benuzzi, Marco Serafini, Giuliana Gessaroli, Valentina Farinelli, Paolo Frigio Nichelli, Stefano Meletti
BACKGROUND: During resting-state EEG-fMRI studies in epilepsy, patients' spontaneous head-face movements occur frequently. We tested the usefulness of synchronous video recording to identify and model the fMRI changes associated with non-epileptic movements to improve sensitivity and specificity of fMRI maps related to interictal epileptiform discharges (IED). NEW METHODS: Categorization of different facial/cranial movements during EEG-fMRI was obtained for 38 patients [with benign epilepsy with centro-temporal spikes (BECTS, n=16); with idiopathic generalized epilepsy (IGE, n=17); focal symptomatic/cryptogenic epilepsy (n=5)]...
January 15, 2015: Journal of Neuroscience Methods
John Buterbaugh, Charles Wynstra, Natalie Provencio, Daniel Combs, Michael Gilbert, Sairam Parthasarathy
STUDY OBJECTIVES: Regional brain alterations may be involved in the pathogenesis and adverse consequences of obstructive sleep apnea (OSA). The objectives for the current study were to (1) determine cerebrovascular reactivity in the motor areas that control upper airway musculature in patients with OSA, and (2) determine whether young patients with OSA have decreased cerebrovascular reactivity in response to breath holding. DESIGN: Case-control study. SETTING: Academic center...
2015: Sleep
Paul Glad Mihai, Mareile Otto, Thomas Platz, Simon B Eickhoff, Martin Lotze
Swallowing consists of a hierarchical sequence of primary motor and somatosensory processes. The temporal interplay of different phases is complex and clinical disturbances frequent. Of interest was the temporal interaction of the swallowing network. Time resolution optimized functional magnetic resonance imaging was used to describe the temporal sequence of representation sites of swallowing and their functional connectivity. Sixteen young healthy volunteers were investigated who swallowed 2 ml of water 20 times per run with a repetition time for functional imaging of 514 ms...
December 2014: Human Brain Mapping
Liang Li, Bin Yan, Li Tong, Linyuan Wang, Jianxin Li
Real-time functional magnetic resonance imaging (rt-fMRI) is a technique that enables us to observe human brain activations in real time. However, some unexpected noises that emerged in fMRI data collecting, such as acute swallowing, head moving and human manipulations, will cause much confusion and unrobustness for the activation analysis. In this paper, a new activation detection method for rt-fMRI data is proposed based on robust Kalman filter. The idea is to add a variation to the extended kalman filter to handle the additional sparse measurement noise and a sparse noise term to the measurement update step...
2014: Computational and Mathematical Methods in Medicine
Yoshiyuki Hirano, Minoru Onozuka
Chewing does not only crush food to aid swallowing and digestion; it also helps to relieve stress and regulate cognitive functions, including alertness and executive function. It is well known that chewing gum is used for sleepiness prevention during work, learning, and driving. In addition, it has been shown in the elderly that a decrease in the number of residual teeth is related to dementia onset. These findings suggest a link between chewing and maintaining memory and attention. Recently, many studies regarding the effects of chewing on memory and attention were conducted using functional magnetic resonance imaging (fMRI) and electroencephalography (EEG)...
January 2014: Brain and Nerve, Shinkei Kenkyū No Shinpo
Bo Luan, Peter Sörös, Ervin Sejdić
Functional connectivity between brain regions during swallowing tasks is still not well understood. Understanding these complex interactions is of great interest from both a scientific and a clinical perspective. In this study, functional magnetic resonance imaging (fMRI) was utilized to study brain functional networks during voluntary saliva swallowing in twenty-two adult healthy subjects (all females, [Formula: see text] years of age). To construct these functional connections, we computed mean partial correlation matrices over ninety brain regions for each participant...
2013: PloS One
Yasuhiro Miyazaki, Kiyokazu Nakajima, Mitsuhiro Sumikawa, Makoto Yamasaki, Tsuyoshi Takahashi, Hiroshi Miyata, Shuji Takiguchi, Yukinori Kurokawa, Noriyuki Tomiyama, Masaki Mori, Yuichiro Doki
PURPOSES: The purpose of this study was to evaluate the feasibility and safety of esophageal functional magnetic resonance imaging (fMRI) for the diagnosis of achalasia. METHODS: Eleven patients with suspected achalasia and three normal subjects underwent fMRI while swallowing clear liquid with original sequences; "T2-weighed single-shot fast spin-echo" and "Fast Imaging Employing Steady-state Acquisition". The fMRI-based diagnosis was compared with that based on manometry...
April 2014: Surgery Today
Paul G Mihai, Oliver von Bohlen Und Halbach, Martin Lotze
Early work on representational specificity and recent findings on temporomandibular joint (TMJ) movement representation raise doubts that a specific swallow representation does exist. Additionally, during cortical stimulation TMJ movements and swallowing show a high overlap of representational areas in the primary motor cortex. It has thus been hypothesized that they overall might share the same neural structures. To differentiate these two movements, we performed a functional MRI (fMRI) study that enabled a direct comparison of functional representation of both actions in the same subject group...
May 15, 2013: American Journal of Physiology. Gastrointestinal and Liver Physiology
Khena M Swallow, Tal Makovski, Yuhong V Jiang
Temporal selection poses unique challenges to the perceptual system. Selection is needed to protect goal-relevant stimuli from interference from new sensory input. In addition, contextual information that occurs at the same time as goal-relevant stimuli may be critical for learning. Using fMRI, we characterized how visual cortical regions respond to the temporal selection of auditory and visual stimuli. Critically, we focused on brain regions that are not involved in processing the target itself. Participants pressed a button when they heard a prespecified target tone and did not respond to other tones...
December 2012: Journal of Neurophysiology
Arash Babaei, B Douglas Ward, Shahryar Ahmad, Anna Patel, Andrew Nencka, Shi-Jiang Li, James Hyde, Reza Shaker
Functional MRI (fMRI) studies have demonstrated that a number of brain regions (cingulate, insula, prefrontal, and sensory/motor cortices) display blood oxygen level-dependent (BOLD) positive activity during swallow. Negative BOLD activations and reproducibility of these activations have not been systematically studied. The aim of our study was to investigate the reproducibility of swallow-related cortical positive and negative BOLD activity across different fMRI sessions. We studied 16 healthy volunteers utilizing an fMRI event-related analysis...
September 1, 2012: American Journal of Physiology. Gastrointestinal and Liver Physiology
U J Chaudhary, R Rodionov, D W Carmichael, R C Thornton, J S Duncan, L Lemieux
RATIONALE: To improve the sensitivity and specificity of simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI) it is prudent to devise modelling strategies explaining the residual variance. The purpose of this study is to investigate the potential value of including additional regressors for physiological activities, derived from video-EEG, in the modelling of haemodynamic patterns linked to interictal epileptiform discharges (IEDs) using simultaneously recorded video-EEG-fMRI...
July 16, 2012: NeuroImage
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