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JOURNAL ARTICLE
Véronique Lenoble, Ana-Marija Cindrić, Jean-François Briand, Maria Luiza Pedrotti, Ana Luzia Lacerda, Soledad Muniategui-Lorenzo, Veronica Fernández-González, Carmen Ma Moscoso-Pérez, José M Andrade-Garda, Raffaella Casotti, Carola Murano, Vincenzo Donnarumma, Sébastien Frizzi, Colin Hannon, Haleigh Joyce, Róisín Nash, João Frias
The term "Plastisphere" refers to the biofilm layer naturally formed by microorganisms attaching to plastic surfaces. This layer possesses the capability to adsorb persistent organic and inorganic pollutants, particularly trace metals, which are the focus of this research study. Immersion experiments were concurrently conducted in five locations spanning four European countries (France, Ireland, Spain, and Italy) utilising eight distinct polymers. These immersions, repeated every three months over a one-year period, aimed to evaluate the baseline bioaccumulation of 12 trace metals...
March 21, 2024: Environmental Pollution
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JOURNAL ARTICLE
Brenda A Nagagata, Gabrielle Brito, Fernanda Ornellas, Carlos A Mandarim-de-Lacerda, Marcia Barbosa Aguila
Maternal obesity might induce obesity and metabolic alterations in the progeny. The study aimed to determine the effect of supplementing obese mothers with Mel (Mel) on thermogenesis and inflammation. C57BL/6 female mice (mothers) were fed from weaning to 12 weeks control diet (C, 17 % kJ as fat) or a high-fat diet (HF, 49 % kJ as fat) and then matted with male mice fed the control diet. Melatonin (10 mg/kg daily) was supplemented to mothers during gestation and lactation, forming the groups C, CMel, HF, and HFMel (n=10/group)...
March 21, 2024: Journal of Nutritional Biochemistry
#23
REVIEW
Lívia de Lacerda de Oliveira, Lúcio Flávio de Alencar Figueiredo
Sorghum is key for global food security due to its genetic variability, resilience, and rich phytonutrient content, which are linked to numerous health benefits. A systematic review assessed the health effects of sorghum by analyzing cell (n = 22), animal (n = 20), and human (n = 7) studies across antioxidant, anti-inflammatory, obesity, cancer, cardiovascular, and diabetes outcomes. This review, involving 42 papers and 177 researchers from 12 countries, collected data from sorghum accessions (acc) and significant effects...
March 22, 2024: Journal of Food Science
#24
JOURNAL ARTICLE
A Yoneda, K J C C de Lacerda, L Alexandre-Santos, E N Itikawa, P Louzada-Junior, L Wichert-Ana
Bone regeneration is crucial for repairing bone tissue following various injuries. Research techniques that enable the study of metabolic changes in bone tissue under different conditions are important for understanding bone repair and remodeling. This study used bone scintigraphy to evaluate osteogenesis secondary to osteotomy in a preclinical model of New Zealand rabbits. For this purpose, we conducted a longitudinal, prospective, case-control study in which scintigraphic variables were measured in both the right forearm (case-operated) and the left forearm (control - non-operated)...
2024: Brazilian Journal of Medical and Biological Research
#25
JOURNAL ARTICLE
Laurent Peyrin-Biroulet, Remo Panaccione, Edouard Louis, Raja Atreya, David T Rubin, James O Lindsay, Jesse Siffledeen, Dana J Lukin, John Wright, Kenji Watanabe, Sharanya Ford, Valencia P Remple, Ana P Lacerda, Elena Dubcenco, Andrew Garrison, Qian Zhou, Sofie Berg, Samuel I Anyanwu, Stefan Schreiber
BACKGROUND & AIMS: Upadacitinib, an oral Janus kinase inhibitor, achieved significantly higher rates of clinical remission and endoscopic response vs placebo during induction (U-EXCEL [NCT03345849]; U-EXCEED [NCT03345836]) and maintenance (U-ENDURE [NCT03345823]) treatment in patients with moderate-to-severe Crohn's disease (CD). Prior biologic failure is often associated with reduced responses to subsequent therapies. This post hoc analysis assessed upadacitinib efficacy by prior biologic failure status...
March 14, 2024: Clinical Gastroenterology and Hepatology
#26
JOURNAL ARTICLE
Jean-Frédéric Colombel, Tadakazu Hisamatsu, Raja Atreya, Francesca Bresso, Lena Thin, Remo Panaccione, Rogério Serafim Parra, Sharanya Ford, Valencia P Remple, Ana Paula Lacerda, Samuel I Anyanwu, Madhuja Mallick, Andrew Garrison, Miguel Regueiro
BACKGROUND & AIMS: Upadacitinib (UPA), an oral Janus kinase inhibitor, is approved to treat moderately to severely active Crohn's disease (CD). As symptomatic response is an important initial treatment goal for patients, we evaluated the rapidity of symptomatic improvement in patients with CD receiving UPA 45 mg once daily (UPA45) induction therapy. METHODS: This post hoc analysis included pooled data from 2 phase 3, multicenter, double-blind 12-week induction trials (U-EXCEL and U-EXCEED) and 1 maintenance trial (U-ENDURE)...
March 14, 2024: Clinical Gastroenterology and Hepatology
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JOURNAL ARTICLE
Sabrina Barros Cavalcante, André Felipe da Silva, Lucas Pradi, Jhuly Wellen Ferreira Lacerda, Tiago Tizziani, Louis Pergaud Sandjo, Lenon Romano Modesto, Ana Claudia Oliveira de Freitas, Mario Steindel, Patricia Hermes Stoco, Rubens Tadeu Delgado Duarte, Diogo Robl
Natural pigments have received special attention from the market and industry as they could overcome the harm to health and the environmental issues caused by synthetic pigments. These pigments are commonly extracted from a wide range of organisms, and when added to products they can alter/add new physical-chemical or biological properties to them. Fungi from extreme environments showed to be a promising source in the search for biomolecules with antimicrobial and antiparasitic potential. This study aimed to isolate fungi from Antarctic soils and screen them for pigment production with antimicrobial and antiparasitic potential, together with other previously isolated strains A total of 52 fungi were isolated from soils in front of the Collins Glacier (Southeast border)...
March 16, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
#28
JOURNAL ARTICLE
Angy Liseth Dávalos, José David Rivera Echeverri, Denize C Favaro, Ronaldo Junio de Oliveira, Gustavo Penteado Battesini Carretero, Caroline Lacerda, Iolanda Midea Cuccovia, Marcus Vinicius Cangussu Cardoso, Chuck S Farah, Roberto Kopke Salinas
The understanding of protein-protein interaction mechanisms is key to the atomistic description of cell signaling pathways and for the development of new drugs. In this context, the mechanism of intrinsically disordered proteins folding upon binding has attracted attention. The VirB9 C-terminal domain (VirB9Ct ) and the VirB7 N-terminal motif (VirB7Nt ) associate with VirB10 to form the outer membrane core complex of the Type IV Secretion System injectisome. Despite forming a stable and rigid complex, VirB7Nt behaves as a random coil, while VirB9Ct is intrinsically dynamic in the free state...
March 15, 2024: ACS Chemical Biology
#29
JOURNAL ARTICLE
Nathalia Zini, Matheus Henrique Tavares Ávila, Natalia Morbi Cezarotti, Maisa Carla Pereira Parra, Cecília Artico Banho, Livia Sacchetto, Andreia Francesli Negri, Emerson Araújo, Cintia Bittar, Bruno Henrique Gonçalves de Aguiar Milhin, Victor Miranda Hernandes, Karina Rocha Dutra, Leonardo Agopian Trigo, Leonardo Cecílio da Rocha, Rafael Alves da Silva, Gislaine Celestino Dutra da Silva, Tamires Fernanda Pereira Dos Santos, Beatriz de Carvalho Marques, Andresa Lopes Dos Santos, Marcos Tayar Augusto, Natalia Franco Bueno Mistrão, Milene Rocha Ribeiro, Tauyne Menegaldo Pinheiro, Thayza Maria Izabel Lopes Dos Santos, Clarita Maria Secco Avilla, Victoria Bernardi, Caroline Freitas, Flora de Andrade Gandolfi, Hélio Correa Ferraz Júnior, Gabriela Camilotti Perim, Mirella Cezare Gomes, Pedro Henrique Carrilho Garcia, Rodrigo Sborghi Rocha, Tayna Manfrin Galvão, Eliane Aparecida Fávaro, Samuel Noah Scamardi, Karen Sanmartin Rogovski, Renan Luiz Peixoto, Luiza Benfatti, Leonardo Teixeira Cruz, Paula Patricia de Freitas Chama, Mânlio Tasso Oliveira, Aripuanã Sakurada Aranha Watanabe, Ana Carolina Bernardes Terzian, Alice de Freitas Versiani, Margareth Regina Dibo, Francisco Chiaravalotti-Neto, Scott Cameron Weaver, Cassia Fernanda Estofolete, Nikos Vasilakis, Mauricio Lacerda Nogueira
BACKGROUND: Chikungunya virus (CHIKV) has spread across Brazil with varying incidence rates depending on the affected areas. Due to cocirculation of arboviruses and overlapping disease symptoms, CHIKV infection may be underdiagnosed. To understand the lack of CHIKV epidemics in São José do Rio Preto (SJdRP), São Paulo (SP), Brazil, we evaluated viral circulation by investigating anti-CHIKV IgG seroconversion in a prospective study of asymptomatic individuals and detecting anti-CHIKV IgM in individuals suspected of dengue infection, as well as CHIKV presence in Aedes mosquitoes...
March 14, 2024: PLoS Neglected Tropical Diseases
#30
JOURNAL ARTICLE
Carlos Brites, Marcus Lacerda, Eduardo Sprinz, Monica Bay, Gustavo Pinto, Pollyanna Azevedo, Estela Luz, Liliane Lins-Kusterer, Eduardo M Netto
BACKGROUND: Currently, integrase inhibitors (INIs)-based ART regimens are the preferred initial therapy for AIDS patients. There is scarce information on the use of dolutegravir (DTG) among late-presenter people living with HIV (PLHIV). OBJECTIVES: To compare the effect of DTG- or efavirenz (EFV)-based regimens on the outcomes of patients with advanced AIDS. METHODS: We compared two cohorts of consecutive symptomatic AIDS patients (WHO stage 4, CD4 count<50 cells/mL) starting therapy with DTG-based (2018-2021, prospective cohort) or EFV-based regimens (2013-2016, retrospective cohort) from five Brazilian cities...
2024: Frontiers in Medicine
#31
JOURNAL ARTICLE
Rossana Cunha, Demócrito de B M Filho, Maria de Fátima P M Albuquerque, Heloísa R Lacerda, George T N Diniz, Ulisses R Montarroyos, Laura C Rodrigues, Líbia Cristina R Vilela Moura, Ricardo A A Ximenes
BACKGROUND: The CD4 T lymphocyte count in people living with HIV (PLHIV) is a predictor for the progression of the disease (AIDS), survival and response to antiretroviral treatment (ART). A CD4 T lymphocyte count of less than 200 cells/mm3 is indicative of a greater risk for the onset of opportunistic diseases and death. Defaulting on treatment for tuberculosis (TB) may impact immune recovery in PLHIV who are taking ART. The aim of this study was to investigate an association of the CD4 lymphocyte with TB treatment Trajectory and with death...
2024: PloS One
#32
JOURNAL ARTICLE
Alberto Soares de Melo, Rayssa Ribeiro da Costa, Francisco Vanies da Silva Sá, Guilherme Felix Dias, Rayanne Silva de Alencar, Priscylla Marques de Oliveira Viana, Tayd Dayvison Custódio Peixoto, Janivan Fernandes Suassuna, Marcos Eric Barbosa Brito, Rener Luciano de Souza Ferraz, Patrícia da Silva Costa, Yuri Lima Melo, Élida Barbosa Corrêa, Claudivan Feitosa de Lacerda, José Dantas Neto
Plant endogenous mechanisms are not always sufficient enough to mitigate drought stress, therefore, the exogenous application of elicitors, such as salicylic acid, is necessary. In this study, we assessed the mitigating action of salicylic acid (SA) in cowpea genotypes under drought conditions. An experiment was conducted with two cowpea genotypes and six treatments of drought stress and salicylic acid (T1 = Control, T2 = drought stress (stress), T3 = stress + 0.1 mM of SA, T4 = stress + 0.5 mM of SA, T5 = stress + 1...
February 26, 2024: Plants (Basel, Switzerland)
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JOURNAL ARTICLE
Danielle Borges Germano, Ana Luíza Pereira Assunção Silveira, Yeon Jung Kim, Jônatas Bussador do Amaral, Marina Tiemi Shio, Luiz Henrique da Silva Nali, Carlos Eduardo Dos Santos Ferreira, Alexandre Miyahira, Francisco Antonio Helfenstein Fonseca, André Luis Lacerda Bachi, Débora Pallos, Carolina Nunes França
The aim of this study was to evaluate the effect of non-surgical periodontal treatment in the expression of chemokine receptors, in individuals with Periodontitis, associated or not with Diabetes. Pilot study, which included patients (n = 45) with Periodontitis, associated (n = 25) or not (n = 20) with Diabetes, submitted to the non-surgical periodontal treatment for one month. The expression of chemokine receptors CCR2, CCR5, and CX3CR1 at the mRNA level was evaluated in the peripheral mononuclear cells, as well as the expression of these receptors at the protein level was verified in monocyte subtypes (classical, intermediate, and non-classical monocytes)...
March 11, 2024: Cytokine
#34
JOURNAL ARTICLE
Natália Teixeira Wnuk, André Felipe Almeida Figueiredo, Talita De Oliveira Farias, Marcos Rocha Gouvêa Brener, Samyra Maria Dos Santos Nassif Lacerda, Vidyleison Neves Camargos, Paulo Henrique Amaral, Lidia Maria Andrade, Maria Ivonete Nogueira Silva, Roberta Araujo Lopes, Raphael Escorsim Szawka, Juan Carlos González, Mauro Martins Teixeira, Danielle da Glória Souza, Vivian Vasconcelos Costa, Guilherme Mattos Jardim Costa
Infection with ZIKV during pregnancy is associated with fetal developmental problems. Although neurological issues are being explored more in experimental studies, limited research has focused on the reproductive health consequences for offspring born to infected mothers. In this context, this study aimed to assess the impact of ZIKV infection during pregnancy on the testes and sperm of adult male offspring. Female mice were intraperitoneally inoculated with a Brazil strain of ZIKV during the 5.5th day of embryonic gestation...
March 1, 2024: Reproduction
#35
Camila Amormino Corsini, Priscila Fernanda da Silva Martins, Priscilla Soares Filgueiras, Adelina Júnia Lourenço, Ana Esther de Souza Lima, Sarah Vieira Contin Gomes, Wander de Jesus Jeremias, Pedro Augusto Alves, Gabriel da Rocha Fernandes, Luciana Lisboa Mota E Castro, Andrea Teixeira-Carvalho, Ana Carolina Campi-Azevedo, Caroline De Almeida Leitao Curimbaba, Daniela Aparecida Lorencini, Eolo Morandi Junior, Victor Mattos da Silva, Maria Célia Cervi, Marcos de Carvalho Borges, Maurício Lacerda Nogueira, Guilherme Rodrigues Fernandes Campos, Paulo Roberto Lopes Correa, Taciana Malheiros Lima Carvalho, Jordana Grazziela Alves Coelho Dos Reis, Erik Vinicius de Sousa Reis, Leda Dos Reis Castilho, Poliana Remundini de Lima, João Paulo Resende do Nascimento, Jaquelline Germano de Oliveira, Olindo Assis Martins-Filho, Rafaella Fortini Queiroz E Grenfell, Immunita Team
Vaccines are essential for the prevention and control of several diseases, indeed, monitoring the immune response generated by vaccines is crucial. The immune response generated by vaccination against SARS-CoV-2 in children and adolescents is not well defined regarding to the intensity and medium to long-term duration of a protective immune response, which may point out the need of booster doses and might support the decisions in public health. Objective The study aims to evaluate the immunogenicity and safety of inactivated SARS-CoV-2 vaccine (CoronaVac) in a two-dose primary protocol in children and adolescent aging from 3 to 17 years old in Brazil...
February 29, 2024: Research Square
#36
JOURNAL ARTICLE
Camila Raquel de Lacerda, Bruna Râmela de Melo, Bruno José Chiaramonte de Castro, Rafael Sartim, Mônica Lopes Aguiar
Although the area with the seam is approximately 4% of the total area of an industrial filter bag, a more extensive investigation of the influence of this region on surface filtration is necessary since the small seam holes can be a conduit for the passage of fine particles even after a certain time of use of the filter bag. Therefore, this work aimed to assess the influence of aging time on the filtration performance of P84 filter bags (samples without and with seam) used in an industrial bag filter, regarding tensile mechanical properties, air permeability, fractional separation efficiency, and filtration cycles...
March 5, 2024: ACS Omega
#37
REVIEW
Cristina Campos Carraro, Patrick Turck, Alan Bahr, Luiza Donatti, Giana Corssac, Denise Lacerda, Alex Sander da Rosa Araujo, Alexandre Luz de Castro, Letícia Koester, Adriane Belló-Klein
Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular resistance (PVR), right ventricular (RV) failure and premature death. Compounds with vasodilatory characteristics, such as β-caryophyllene, could be promising therapeutics for PAH. This study aimed to determine the effects of free and nanoemulsified β-caryophyllene in lung oxidative stress and heart function in PAH rats. Male Wistar rats (170 g, n = 6/group) were divided into four groups: control (CO), monocrotaline (MCT), monocrotaline + β-caryophyllene (MCT-Bcar) and monocrotaline + nanoemulsion with β-caryophyllene (MCT-Nano)...
March 8, 2024: Biochimica et Biophysica Acta. Molecular Cell Research
#38
JOURNAL ARTICLE
Thiago Antonio de Sousa Cutrim, Mariana Alves Eloy, Fernando Fontes Barcelos, Leandra Martins Meireles, Lara Chaves de Freitas Ferreira, Tatiana Alves Reis, Sarah Santos Gonçalves, Valdemar Lacerda, Marcio Fronza, Pedro Alves Bezerra Morais, Rodrigo Scherer
Fungal infections have emerged worldwide, and azole antifungals are widely used to control these infections. However, the emergence of antifungal resistance has been compromising the effectiveness of these drugs. Therefore, the objective of this study was to evaluate the antifungal and cytotoxic activities of the nine new 1,2,3 triazole compounds derived from thymol that were synthesized through Click chemistry. The binding mode prediction was carried out by docking studies using the crystallographic structure of Lanosterol 14α-demethylase G73E mutant from Saccharomyces cerevisiae...
March 8, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
#39
JOURNAL ARTICLE
Marcelo Brito, Rosilene Rufatto, José Diego Brito-Sousa, Felipe Murta, Vanderson Sampaio, Patrícia Balieiro, Djane Baía-Silva, Vanessa Castro, Brenda Alves, Aline Alencar, Stephan Duparc, Penny Grewal Daumerie, Isabelle Borghini-Fuhrer, Elodie Jambert, Cássio Peterka, Francisco Edilson Lima, Leonardo Carvalho Maia, Catherine Lucena Cruz, Bruna Maciele, Mariana Vasconcelos, Myrna Machado, Elder Augusto Figueira, Antônio Alcirley Balieiro, Dhelio Batista Pereira, Marcus Lacerda
BACKGROUND: Prevention of Plasmodium vivax malaria recurrence is essential for malaria elimination in Brazil. We evaluated the real-world effectiveness of an updated treatment algorithm for P vivax radical cure in the Brazilian Amazon. METHODS: In this non-interventional observational study, we used retrospective data from the implementation of a P vivax treatment algorithm at 43 health facilities in Manaus and Porto Velho, Brazil. The treatment algorithm consisted of chloroquine (25 mg/kg over 3 days) and point-of-care quantitative glucose-6-phosphate dehydrogenase (G6PD) testing followed by single-dose tafenoquine 300 mg (G6PD normal, aged ≥16 years, not pregnant and not breastfeeding), 7-day primaquine 0·5 mg/kg per day (G6PD intermediate or normal, aged ≥6 months, not pregnant, and not breastfeeding or breastfeeding for >1 month), or primaquine 0·75 mg/kg per week for 8 weeks (G6PD deficient, aged ≥6 months, not pregnant, and not breastfeeding or breastfeeding for >1 month)...
March 4, 2024: Lancet Infectious Diseases
#40
JOURNAL ARTICLE
Luís Renato Dos Santos Mascarenhas, Adriana Marcos Vivoni, Renata Gomes Caetano, Leonardo Alves Rusak, Verônica Ortiz Alvarenga, Inayara Cristina Alves Lacerda
Bacillus cereus sensu stricto (s.s.) is a well-known foodborne pathogen that produces a range of enterotoxins and is able to cause two different types of foodborne illnesses-the emetic and the diarrheal syndromes. In this study, 54 B. cereus s.s. strains isolated from foodstuff and foods involved in food poisoning outbreaks were characterized according to the presence of toxin-encoding genes, virulence-encoding genes, and panC typing. Most isolates were assigned to panC groups IV (61.1%) and III (25.9%), but members of groups II and V could also be found...
March 6, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
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