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https://www.readbyqxmd.com/read/29791635/elderly-people-with-mental-disorders-experiencing-the-use-of-psychotropic-medicines
#1
Maria José Sanches Marin, Mariluci Alves Maftum, Maria Ribeiro Lacerda
OBJECTIVE: To interpret the experience of the elderly with mental disorder in the use of psychotropic medicines. METHOD: Qualitative study in the interpretative modality, supported by the Grounded Theory. It was carried out from interviews with 16 elderly people with mental disorder and six relatives, totaling 22 participants. RESULTS: In the experience of the use of psychotropic medicines, the elderly with mental disorders become aware of their condition, attribute meaning and establish strategies for the correct use...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29789839/a-cocktail-of-165-er-iii-and-gd-iii-complexes-for-quantitative-detection-of-zinc-using-spect-and-mri
#2
Kyangwi P Malikidogo, Isidro Da Silva, Jean-François Morfin, Sara Lacerda, Laurent Barantin, Thierry Sauvage, Julien Sobilo, Stéphanie Lerondel, Éva Tóth, Célia S Bonnet
We propose quantitative assessment of zinc by combining nuclear and MR imaging. We use a cocktail of a Gd3+-complex providing a Zn2+-dependent MRI response and its 165Er3+ analogue allowing for concentration assessment. 165Er is readily obtained in a cyclotron and purified, which is indispensable for successful quantification of metal ions.
May 23, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29777448/triad-of-the-ischemic-cardiovascular-disease-in-people-living-with-hiv-association-between-risk-factors-hiv-infection-and-use-of-antiretroviral-therapy
#3
REVIEW
Hugo Ribeiro Zanetti, Edmar Lacerda Mendes, Antonio Carlos Palandri Chagas, Maria Odila Gomes Douglas, Leandro Teixeira Paranhos Lopes, Leonardo Roever, Alexandre Gonçalves, Elmiro Santos Resende
PURPOSE OF REVIEW: This review is focused on cardiovascular risk factors in HIV-infected people. RECENT FINDINGS: Antiretroviral therapy (ART) has significantly increased the life expectancy of HIV-infected people. Thus, this population has experienced non-HIV-related diseases, mainly cardiovascular diseases. Thus, in our review, we intend to understand the cardiovascular risk factors that trigger this situation. We have demonstrated that both ART and traditional cardiovascular risk factors contribute to the development of cardiovascular disease in HIV-infected people...
May 18, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29771131/mouthwash-containing-croton-doctoris-essential-oil-in-vitro-study-using-a-validated-model-of-caries-induction
#4
Yasmin Etienne Albuquerque, Marcelle Danelon, Marcos José Salvador, Cristiane Yumi Koga-Ito, Alberto Carlos Botazzo Delbem, Román Yesid Ramirez-Rueda, Aline Vidal Lacerda Gontijo, Fernanda Lourenção Brighenti
AIM: To validate an in vitro caries model and to evaluate an experimental mouthwash containing Croton doctoris essential oil.  Materials & methods: To validate the experimental model, we used McBain medium and polymicrobial biofilms. The EOM (essential oil mouthwash) was tested using the validated model. Microbial composition (colony-forming unit/ml), acidogenicity, enamel demineralization (percentage of surface enamel hardness loss), cytotoxicity and essential oil composition were evaluated...
May 17, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29768541/vascular-endothelial-growth-factor-association-with-angiopoietin-1-promotes-improvement-in-ventricular-function-after-ischemic-cardiomyopathy-induced-in-mini-pigs
#5
André Lacerda de Abreu Oliveira, Jussara Peters Scheffer, Melissa Markoski, Andreia Koche, Alexsandra Balbinot, Fernanda Antunes, Renato Kalil
PURPOSE: To investigate the safety and clinical, hemodynamic and tissue improvement ability in mini pigs undergoing cell and gene therapy for the treatment of acute myocardial infarction. METHODS: Thirty-two mini pigs Br1 lineage, 12 months old, undergoing induction of acute myocardial infarction by occlusion of the diagonal branch of the paraconal coronary. They were divided into 4 groups: one control group and 3 treatment groups (cell therapy and gene cell therapy)...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768522/tif4-varnish-protects-the-retention-of-brackets-to-enamel-after-in-vitro-mild-erosive-challenge
#6
Maria Isabel Dantas de Medeiros, Hugo Lemes Carlo, Rogério Lacerda Dos Santos, Frederico Barbosa Sousa, Ricardo Dias de Castro, Renata Cristina Sobreira França, Fabíola Galbiatti de Carvalho
The effect of fluoride agents on the retention of orthodontic brackets to enamel under erosive challenge is little investigated. The aim of this study was to evaluate the effect of titanium tetrafluoride (TiF4) and sodium fluoride (NaF) agents on the shear bond strength of brackets to enamel and on the enamel microhardness around brackets under erosive challenge. Brackets were bonded to bovine incisors. Five groups were formed according to fluoride application (n=10): TiF4 varnish, TiF4 solution, NaF varnish, NaF solution and control (without application)...
May 14, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29755558/antiparasitic-activity-and-essential-oil-chemical-analysis-of-the-piper-tuberculatum-jacq-fruit
#7
Valterlúcio Dos Santos Sales, Álefe Brito Monteiro, Gyllyandeson de Araújo Delmondes, Emmily Petícia do Nascimento, Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo, Cristina Kelly de Souza Rodrigues, Josefa Fernanda Evangelista de Lacerda, Cícera Norma Fernandes, Maysa de Oliveira Barbosa, Adamo Xenofonte Brasil, Saulo Relison Tintino, Maria Celeste Vega Gomez, Cathia Coronel, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa, Cícero Francisco Bezerra Felipe, Irwin Rose Alencar de Menezes, Marta Regina Kerntopf
With the increase of neglected diseases such as leishmaniasis and Chagas disease, there was a need for the search for new therapeutic alternatives that reduce the harm caused by medicine available for treatment. Thus, this study was performed to investigate the antiparasitic activity of the essential oil from the fruits of Piper tuberculatum Jacq, against lines of Leishmania braziliensis (MHOM/CO/88/UA301), Leishmania infantum (MHOM/ES/92/BCN83) and Trypanosoma cruzi (LC-B5 clone). Before running protocols, an analysis of the chemical composition of essential oil was conducted, which presented monoterpenes and sesquiterpenes...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29753110/inorganic-phosphate-transporters-in-cancer-functions-molecular-mechanisms-and-possible-clinical-applications
#8
REVIEW
Marco Antônio Lacerda-Abreu, Thais Russo-Abrahão, Robson de Queiroz Monteiro, Franklin David Rumjanek, José Roberto Meyer-Fernandes
Inorganic phosphate is one of the most essential nutrients for the maintenance of cell life. Because of its essential role in nutrient supplementation, the study of plasma membrane inorganic phosphate transporters in cancer biology has received much attention in recent years. Several studies suggest that these transporters are up-regulated in tumor cells and thus have been considered to be important promoters of tumor progression. Altered expression levels of inorganic phosphate transporters, such as NaPi-IIb (SLC34A2) and PiT-1 (SLC20A1), have been demonstrated...
May 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29749107/mutation-analysis-of-the-pah-gene-in-phenylketonuria-patients-from-rio-de-janeiro-southeast-brazil
#9
Eduardo Vieira Neto, Francisco Laranjeira, Dulce Quelhas, Isaura Ribeiro, Alexandre Seabra, Nicole Mineiro, Lilian D M Carvalho, Lúcia Lacerda, Márcia G Ribeiro
BACKGROUND: Phenylketonuria (PKU) is an autosomal recessive disease resulting from mutations in the PAH gene. Most of the patients are compound heterozygotes, and genotype is a major factor in determining the phenotypic variability of PKU. More than 1,000 variants have been described in the PAH gene. Rio de Janeiro's population has a predominance of Iberian, followed by African and Amerindian ancestries. It is expected that most PKU variants in this Brazilian state have originated in the Iberian Peninsula...
May 10, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29747211/tocolysis-among-women-with-preterm-birth-associated-factors-and-outcomes-from-a-multicenter-study-in-brazil
#10
Tabata Zumpano Dias, Mariana Lacerda Fava, Renato Passini Júnior, Jose Guilherme Cecatti, Ricardo Porto Tedesco, Giuliane Jesus Lajos, Patricia Moretti Rehder, Marcelo Luis Nomura, Paulo Fanti Oliveira, Maria Laura Costa
OBJECTIVE:  To evaluate the use of tocolysis in cases of preterm birth due to spontaneous preterm labor in a Brazilian sample. METHODS:  A sample of 1,491 women with preterm birth due to spontaneous preterm labor were assessed, considering treatment with tocolysis or expectant management, according to gestational age at birth (< 34 weeks and 34 to 36 + 6 weeks) and drugs prescribed. The study took place in 20 Brazilian hospitals from April 2011 to July 2012...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29741139/identification-characterization-and-molecular-modelling-studies-of-schistosoma-mansoni-dihydrofolate-reductase-inhibitors-from-assay-development-to-hit-identification
#11
Andre Lacerda Braga Teles, Roseane R Silva, Michelle Ko, Glaucio Monteiro Ferreira, Samuel da Rocha Pita, Gustavo Henrique Goulart Trossini, Paulo Carvalho, Marcelo Santos Castilho
Schistosoma mansoni is responsible for virtually all reported cases of schistosomiasis in Latin America and the emergence of praziquantel- and oxaminiquine-resistant strains makes it urgent to develop new schistosomicide agents. Dihydrofolate reductases (DHFR) from bacteria and protozoan parasites are considered validated macromolecular targets for this goal, but S. mansoni DHFR (SmDHFR) has been largely overlooked. To fill this gap in knowledge, the present work describes optimized conditions to carry out thermal shift assays with SmDHFR, as well as a balanced kinetic assay that supports 2,4-diaminopyrimidine derivatives as SmDHFR inhibitors...
May 9, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29737428/the-ratios-of-pro-inflammatory-to-anti-inflammatory-cytokines-in-the-serum-of-chronic-periodontitis-patients-with-and-without-type-2-diabetes-and-or-smoking-habit
#12
Tamires Szeremeske Miranda, Sílvia Lacerda Heluy, Daniele Ferreira Cruz, Hélio Doyle Pereira da Silva, Magda Feres, Luciene Cristina Figueiredo, Poliana Mendes Duarte
OBJECTIVE: This study assessed the impact of chronic periodontitis (CP) and CP associated with type 2 diabetes mellitus (DM) and/or smoking on the serum ratios of pro- to anti-inflammatory cytokines. MATERIALS AND METHODS: Subjects were assigned into one of the following groups: control (n = 25, non-diabetic non-smokers with no history of periodontitis), CP (n = 26, non-diabetic non-smokers with CP), DMCP (n = 30, non-smokers with DM and CP), SCP (n = 27, non-diabetic smokers with CP), and SDMCP (n = 22, smokers with type 2 DM and CP)...
May 8, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29737408/molecular-characterization-of-avipoxviruses-circulating-in-mozambique-2016-2018
#13
Lourenço P Mapaco, Zeiss Lacerda, Iolanda V A Monjane, Afonso Sussuro, Gerrit J Viljoen, Giovanni Cattoli, William G Dundon, Sara J Achá
Samples from 45 chickens, two turkeys, one peacock and one quail with symptoms of fowlpox were collected in Mozambique between November 2016 and January 2018. Phylogenetic analysis revealed that the samples contained avipoxviruses belonging to both clade A1 and clade A2. In addition, all of the Clade A1 viruses were positive by PCR for the integration of reticuloendotheliosis virus, while the clade A2 avipoxvirus samples were negative. This study confirms the circulation of clade A1 avipoxviruses in Mozambique in addition to identifying clade A2 for the first time in the country...
May 8, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29736910/preharvest-factors-related-to-sensory-profile-of-passiflora-setacea-nectars-a-wild-passion-fruit-from-brazilian-savannah
#14
Mariana Veras Oliveira de Carvalho, Lívia de Lacerda de Oliveira, Lauro Melo, Ana Maria Costa
BACKGROUND: Passiflora setacea D.C is a passion fruit species native from Brazilian savannah characterized by naturally sweet sensory characteristics. Sensory quality of the pulp can be affected by growing environment. The effect of training systems (trellis or espalier), seasons (the weather conditions in periods of drought and rain) and addition of seeds to the juice (25%) were evaluated, with emphasis on the sensory quality of Passiflora setacea nectars. RESULTS: Training systems of P...
May 8, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29736662/serous-pancreatic-cystadenoma-with-compression-of-wirsung-s-duct
#15
Enio Campos Amico, José Roberto Alves, Adriano de Araújo Lima Liguori, Rogério Lacerda Sousa
Serous cystadenoma of the pancreas is a common cystic neoplasm typically of benign evolution that rarely communicates with the pancreatic ductal system. We present several images originating from two cases of serous cystadenoma of the pancreas which led to compression and dilatation of Wirsung's duct. These cases suggest that when the diagnosis of pancreatic microcystic lesion is detected, associated, or not associated with a central fibrous scar and a low carcinoembryonic antigen level in the aspirated fluid, the presence of dilatation of Wirsung's duct does not exclude the diagnosis of serous pancreatic cystadenoma...
May 7, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29728152/infection-of-anopheles-aquasalis-from-symptomatic-and-asymptomatic-plasmodium-vivax-infections-in-manaus-western-brazilian-amazon
#16
Keillen M Martins-Campos, Andrea Kuehn, Anne Almeida, Ana Paula M Duarte, Vanderson S Sampaio, Íria C Rodriguez, Sara G M da Silva, Claudia María Ríos-Velásquez, José Bento Pereira Lima, Paulo Filemon Paolucci Pimenta, Quique Bassat, Ivo Müller, Marcus Lacerda, Wuelton M Monteiro, Maria das Graças V Barbosa Guerra
BACKGROUND: Asymptomatic individuals are one of the major challenges for malaria elimination programs in endemic areas. In the absence of clinical symptoms and with a lower parasite density they constitute silent reservoirs considered important for maintaining transmission of human malaria. Studies from Brazil have shown that infected individuals may carry these parasites for long periods. RESULTS: Patients were selected from three periurban endemic areas of the city of Manaus, in the western Brazilian Amazon...
May 4, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29723584/preclinical-safety-evaluation-of-the-ethanolic-extract-from-guavira-fruits-campomanesia-pubescens-d-c-o-berg-in-experimental-models-of-acute-and-short-term-toxicity-in-rats
#17
Gustavo Roberto Villas Boas, Ariany Carvalho Dos Santos, Roosevelt Isaias Carvalho Souza, Flávio Henrique Souza de Araújo, Giseli Karenina Traesel, Jhony Moreira Marcelino, Ana Paula Stefanello da Silveira, Brunna Charla Feitosa Farinelli, Claudia Andréa Lima Cardoso, Roseli Boerngen de Lacerda, Silvia Aparecida Oesterreich
Campomanesia pubescens is a fruit plant widely distributed in South America and used by the population for medicinal and nutritional purposes, with important economic and cultural value. This study evaluated the toxic potential of the ethanolic extract from C. pubescens (EEFCP) fruits through acute and short-term toxicity tests. For the acute toxicity test, female rats received a single oral dose of 2000 mg/kg body weight of EEFCP and were observed for 14 days. In the short-term toxicity test, male and female rats received repeated oral doses of 125, 250, 500 or 1000 mg/kg of EEFCP, being treated and observed for 28 days, and after the treatment period, a satellite and satellite control group remained under observation for another 14 days...
April 30, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29722619/whole-body-vibration-training-increases-physical-measures-and-quality-of-life-without-altering-inflammatory-oxidative-biomarkers-in-patients-with-moderate-copd
#18
Camila Danielle Cunha Neves, Ana Cristina Rodrigues Lacerda, Vanessa Kelly Silva Lage, Aline Alves Soares, Maria Gabriela Abreu Chaves, Liliana Pereira Lima, Thyago José Silva, Érica Leandro Marciano Vieira, Antônio Lúcio Teixeira, Hércules Ribeiro Leite, Mariana Aguiar Matos, Vanessa Amaral Mendonça
The whole-body vibration training (WBVT) has been identified as an alternative intervention to improve exercise capacity and quality of life of patients with Chronic Obstructive Pulmonary Disease (COPD). However, the effect of WBVT on inflammatory-oxidative biomarkers remains unknown. The aim of this trial was to investigate the effects of WBVT on quality of life and physical and inflammatory-oxidative parameters in patients with COPD. Twenty patients were equally divided into: 1) intervention group (IG) that performed the WBVT, and 2) control group (CG) that did not receive any intervention...
May 3, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29710028/vitamin-d-deficiency-increases-lipogenesis-and-reduces-beta-oxidation-in-the-liver-of-diet-induced-obese-mice
#19
Celina Carvalho Borges, Andreza Fernandes Salles, Isabele Bringhenti, Carlos Alberto Mandarim-DE-Lacerda, Marcia Barbosa Aguila
The study was conducted to understand better the mechanisms involved in liver changes when there is a combination of diet-induced obesity (DIO) and vitamin D deficiency (VDD). After 8 wk of feeding a control diet (C group) or a high-fat diet (HF), both with vitamin D, and counterpart groups without vitamin D (VitD- groups), we found in plasma: higher alanine aminotransferase, and aspartate aminotransferase in the VitD- groups, and more elevated total cholesterol in the HF group. Compared to their counterparts, HF and HF/VitD- showed hyperinsulinemia and higher hepatic triglycerides and steatosis...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29694776/apparent-softening-of-wet-graphene-membranes-on-a-microfluidic-platform
#20
Gustavo A Ferrari, Alan B de Oliveira, Ive Silvestre, Matheus J S Matos, Ronaldo J C Batista, Thales F D Fernandes, Leonel M Meireles, Gomes S N Eliel, Helio Chacham, Bernardo R A Neves, Rodrigo G Lacerda
Graphene is regarded as the toughest two-dimensional material (highest in-plane elastic properties) and, as a consequence, it has been employed/proposed as an ultrathin membrane in a myriad of microfluidic devices. Yet, an experimental investigation of eventual variations on the apparent elastic properties of a suspended graphene membrane in contact with air or water is still missing. In this work, the mechanical response of suspended monolayer graphene membranes on a microfluidic platform is investigated via scanning probe microscopy experiments...
April 27, 2018: ACS Nano
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