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https://www.readbyqxmd.com/read/28715874/detection-of-bacterial-infection-by-a-technetium-99m-labeled-peptidoglycan-aptamer
#1
Iêda Mendes Ferreira, Camila Maria de Sousa Lacerda, Sara Roberta Dos Santos, André Luís Branco de Barros, Simone Odília Fernandes, Valbert Nascimento Cardoso, Antero Silva Ribeiro de Andrade
Nuclear medicine clinicians are still waiting for the optimal scintigraphic imaging agents capable of distinguishing between infection and inflammation, and between fungal and bacterial infections. Aptamers have several properties that make them suitable for molecular imaging. In the present study, a peptidoglycan aptamer (Antibac1) was labeled with (99m)Tc and evaluated by biodistribution studies and scintigraphic imaging in infection-bearing mice. Labeling with (99m)Tc was performed by the direct method and the complex stability was evaluated in saline, plasma and in the molar excess of cysteine...
July 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28714806/loss-of-control-over-the-ethanol-consumption-differential-transcriptional-regulation-in-prefrontal-cortex
#2
Carolina de Paiva Lima, Daniel Almeida da Silva E Silva, Samara Damasceno, Andrea Frozino Ribeiro, Cristiane S Rocha, Alexandre H Berenguer de Matos, Diego Correia, Roseli Boerngen-Lacerda, Ana Lúcia Brunialti Godard
Alcohol use disorder (AUD) is a complex multifactorial disease with heritability of ∼50% and corresponds to the state in which the body triggers a reinforcement or reward compulsive behavior due to ethanol consumption, even when faced with negative consequences. Although several studies have shown the impact of high ethanol intake on the prefrontal cortex (PFC) gene expression, few have addressed the relationship between the patterns of gene expression underlying the compulsive behaviour associated with relapsing...
July 17, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/28713482/comparative-therapeutic-effects-of-minocycline-treatment-and-bone-marrow-mononuclear-cell-transplantation-following-striatal-stroke
#3
Celice C Souza, Michelle Castro da Silva, Rosana Telma Lopes, Marcelo M Cardoso, Lucas Lacerda de Souza, Adriano Guimarães Santos, Ijair Rogério Dos Santos, Edna C S Franco, Walace Gomes-Leal
We explored the comparative effects of minocycline treatment and intrastriatal BMMC transplantation after experimental striatal stroke in adult rats. Male Wistar adult rats were divided as follows: saline-treated (N = 5), minocycline-treated (N = 5), and BMMC-transplanted (N = 5) animals. Animals received intrastriatal microinjections of 80 pmol of endothelin-1 (ET-1). Behavioral tests were performed at 1, 3, and 7 days postischemia. Animals were treated with minocycline (50 mg/kg, i.p.) or intrastriatal transplants of 106 BMMCs at 24 h postischemia...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28712638/canal-transportation-unprepared-areas-and-dentin-removal-after-preparation-with-bt-race-and-protaper-next-systems
#4
Sabrina C Brasil, Marília F Marceliano-Alves, Márcia L Marques, João P Grillo, Mariane F L S Lacerda, Flávio R F Alves, José F Siqueira, José C Provenzano
INTRODUCTION: This study compared the shaping ability of ProTaper Next (Dentsply Sirona, Tulsa, OK) and BT-RaCe (FKG Dentaire, La Chaux-de-Fonds, Switzerland) instrument systems in the mesial canals of mandibular molars using micro-computed tomographic (micro-CT) imaging. METHODS: A total of 17 type IV mesial roots of extracted first mandibular molars were scanned using micro-CT imaging before and after root canal preparation with the 2 instrument systems. Both systems were used in the same root but alternating the mesial canals from root to root...
July 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28711683/anti-obesogenic-effects-of-wy14643-ppar-alpha-agonist-hepatic-mitochondrial-enhancement-and-suppressed-lipogenic-pathway-in-diet-induced-obese-mice
#5
Flavia Maria Silva Veiga, Francielle Graus-Nunes, Tamiris Lima Rachid, Aline Barcellos Barreto, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello
Non-alcoholic fatty liver disease (NAFLD) presents with growing prevalence worldwide, though its pharmacological treatment remains to be established. This study aimed to evaluate the effects of a PPAR-alpha agonist on liver tissue structure, ultrastructure, and metabolism, focusing on gene and protein expression of de novo lipogenesis and gluconeogenesis pathways, in diet-induced obese mice. Male C57BL/6 mice (three months old) received a control diet (C, 10% of lipids, n = 10) or a high-fat diet (HFD, 50% of lipids, n = 10) for ten weeks...
July 12, 2017: Biochimie
https://www.readbyqxmd.com/read/28704618/paracoccidioides-brasiliensis-presents-metabolic-reprogramming-and-secretes-a-serine-proteinase-during-murine-infection
#6
Laurine Lacerda Pigosso, Lilian Cristiane Baeza, Mariana Vieira Tomazett, Mariana Batista Rodrigues Faleiro, Veridiana Maria Brianezi Dignani de Moura, Alexandre Melo Bailão, Clayton Luiz Borges, Juliana Alves Parente Rocha, Gabriel Rocha Fernandes, Gregory M Gauthier, Celia Maria de Almeida Soares
Paracoccidoides brasiliensis and Paracoccidioides lutzii, the etiologic agents of paracoccidioidomycosis, cause disease in healthy and immunocompromised persons in Latin America. We developed a method for harvesting P. brasiliensis yeast cells from infected murine lung to facilitate in vivo transcriptional and proteomic profiling. P. brasiliensis harvested at 6 h post-infection were analyzed using RNAseq and LC-MS(E). In vivo yeast cells had 594 differentially expressed transcripts and 350 differentially expressed proteins...
July 13, 2017: Virulence
https://www.readbyqxmd.com/read/28703274/pterostilbene-reduces-oxidative-stress-prevents-hypertrophy-and-preserves-systolic-function-of-right-ventricle-in-cor-pulmonale-model
#7
Denise Dos Santos Lacerda, Patrick Türck, Bruna Gazzi de Lima-Seolin, Rafael Colombo, Vanessa Duarte Ortiz, Jéssica Hellen Poletto Bonetto, Cristina Campos-Carraro, Sara Elis Bianchi, Adriane Belló-Klein, Valquiria LinckBassani, Alex Sander da Rosa Araujo
BACKGROUND AND PURPOSE: In cor pulmonale, the increased afterload imposed on the right ventricle (RV) generates a maladaptive response, impairing the contractile cardiac function. Oxidative mechanisms play an important role in the pathophysiology and progression of this disease. The administration of pterostilbene (PTS), a phyto-phenol with antioxidant potential, may represent a therapeutic alternative. In the present study, the objective was to evaluate the effect of PTS complexed with hydroxypropyl-β-cyclodextrin (HPβCD) on hypertrophy, contractile function and oxidative parameters in the RV of rats with pulmonary hypertension induced by monocrotaline administration...
July 12, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28702166/venous-occlusion-test-applied-to-the-tributaries-of-the-superior-mesenteric-veins-of-the-pancreas-head-infiltrated-by-tumor
#8
Enio Campos Amico, José Roberto Alves, Samir Assi João, Joafran Alexandre Costa de Medeiros, Rogério Lacerda Sousa
A 64-year-old white woman presented with cholestatic jaundice, weight loss and a solid lesion in the pancreas head. At multislice computed tomography, a superior mesenteric vein (SMV) and one of it tributaries showed signs of tumor infiltration. At surgery, a venous occlusion test applied to the infiltrated tributary of the SMV showed immediate venous congestion in two-thirds of the distal small intestine. No reconstruction attempt was made due to the small size of the vessel. A biliodigestive anastomosis and lymph node biopsy was performed...
June 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28700692/gallic-acid-hydroxypropyl-%C3%AE-cyclodextrin-complex-improving-solubility-for-application-on-in-vitro-in-vivo-candida-albicans-biofilms
#9
Guilherme Rodrigues Teodoro, Aline Vidal Lacerda Gontijo, Aline Chiodi Borges, Márcia Hiromi Tanaka, Gabriela de Morais Gouvêa Lima, Marcos José Salvador, Cristiane Yumi Koga-Ito
The aim of this study was to increase the solubility of gallic acid (GA) for the treatment of Candida albicans biofilm, which is very difficult to treat and requires high drug concentrations. Cyclodextrins (CDs) were used for this purpose. Complexes were evaluated by phase-solubility studies, prepared by spray drying and characterized by drug loading, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The complexes were tested on C. albicans biofilm using in vitro and in vivo models...
2017: PloS One
https://www.readbyqxmd.com/read/28692641/poor-efficacy-of-preemptive-amoxicillin-clavulanate-for-preventing-secondary-infection-from-bothrops-snakebites-in-the-brazilian-amazon-a-randomized-controlled-clinical-trial
#10
Jacqueline A G Sachett, Iran Mendonça da Silva, Eliane Campos Alves, Sâmella S Oliveira, Vanderson S Sampaio, Fábio Francesconi do Vale, Gustavo Adolfo Sierra Romero, Marcelo Cordeiro Dos Santos, Hedylamar Oliveira Marques, Mônica Colombini, Ana Maria Moura da Silva, Fan Hui Wen, Marcus V G Lacerda, Wuelton M Monteiro, Luiz C L Ferreira
BACKGROUND: Secondary bacterial infections from snakebites contribute to the high complication rates that can lead to permanent function loss and disabilities. Although common in endemic areas, routine empirical prophylactic use of antibiotics aiming to prevent secondary infection lacks a clearly defined policy. The aim of this work was to estimate the efficacy of amoxicillin clavulanate for reducing the secondary infection incidence in patients bitten by Bothrops snakes, and, secondarily, identify risk factors for secondary infections from snakebites in the Western Brazilian Amazon...
July 10, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28683356/scintigraphic-imaging-of-staphylococcus-aureus-infection-using-99m-tc-radiolabeled-aptamers
#11
Sara Roberta Dos Santos, Camila Maria de Sousa Lacerda, Iêda Mendes Ferreira, André Luís Branco de Barros, Simone Odília Fernandes, Valbert Nascimento Cardoso, Antero Silva Ribeiro de Andrade
Staphylococcus aureus is a specie of great medical importance associated with many infections as bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device related infections. Early identification of infectious foci is crucial for successful treatment. Scintigraphy could contribute to this purpose since specific radiotracers were available. Aptamers due to their high specificity have great potential for radiopharmaceuticals development. In the present study scintigraphic images of S...
June 28, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28681199/beneficial-effects-of-liraglutide-glp1-analog-in-the-hippocampal-inflammation
#12
Andre R C Barreto-Vianna, Marcia B Aguila, Carlos A Mandarim-de-Lacerda
The brain is very sensitive to metabolic dysfunctions induced by diets high in saturated fatty acids, leading to neuroinflammation. The liraglutide has been found to have neuroprotective effects. However, its neuroprotective action in a model of palmitate-induced neuroinflammation had not yet been evaluated. Mice were intracerebroventricular (ICV) infused with palmitate and received subcutaneous liraglutide. The hippocampal dentate gyrus and CA1 regions were analyzed (morphology and inflammation-related proteins in microglia and astrocyte by confocal microscopy)...
July 5, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28676757/greater-cortical-thickness-in-elderly-female-yoga-practitioners-a-cross-sectional-study
#13
Rui F Afonso, Joana B Balardin, Sara Lazar, João R Sato, Nadja Igarashi, Danilo F Santaella, Shirley S Lacerda, Edson Amaro, Elisa H Kozasa
Yoga, a mind-body activity that requires attentional engagement, has been associated with positive changes in brain structure and function, especially in areas related to awareness, attention, executive functions and memory. Normal aging, on the other hand, has also been associated with structural and functional brain changes, but these generally involve decreased cognitive functions. The aim of this cross-sectional study was to compare brain cortical thickness (CT) in elderly yoga practitioners and a group of age-matched healthy non-practitioners...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28676055/malaria-in-brazil-colombia-peru-and-venezuela-current-challenges-in-malaria-control-and-elimination
#14
REVIEW
Judith Recht, André M Siqueira, Wuelton M Monteiro, Sonia M Herrera, Sócrates Herrera, Marcus V G Lacerda
In spite of significant progress towards malaria control and elimination achieved in South America in the 2000s, this mosquito-transmitted tropical disease remains an important public health concern in the region. Most malaria cases in South America come from Amazon rain forest areas in northern countries, where more than half of malaria is caused by Plasmodium vivax, while Plasmodium falciparum malaria incidence has decreased in recent years. This review discusses current malaria data, policies and challenges in four South American Amazon countries: Brazil, Colombia, Peru and the Bolivarian Republic of Venezuela...
July 4, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28670025/high-resolution-computed-tomography-findings-in-eight-patients-with-hantavirus-pulmonary-syndrome
#15
Diego de Lacerda Barbosa, Bruno Hochhegger, Arthur Soares Souza, Gláucia Zanetti, Dante Luiz Escuissato, Gustavo de Souza Portes Meirelles, Marcelo Buarque de Gusmão Funari, Edson Marchiori
OBJECTIVE: The purpose of this study was to describe the high-resolution computed tomography (HRCT) findings in patients with hantavirus pulmonary syndrome (HPS). MATERIALS AND METHODS: We retrospectively reviewed HRCT findings from eight cases of HPS. All patients were men, aged 19-70 (mean, 41.7) years. Diagnoses were established by serological test (enzyme-linked immunosorbent assay) in all patients. Two chest radiologists analyzed the images and reached decisions by consensus...
May 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28658459/advertising-of-tobacco-products-at-point-of-sale-who-are-more-exposed-in-brazil
#16
Adriana Bacelar Ferreira-Gomes, Lenildo de Moura, Silvânia Suely de Araújo-Andrade, Felipe Lacerda-Mendes, Cristina A Perez, Zohra Abaakouk
Objective: To describe the adult population perception of cigarette advertising at point of sale, according their tobacco-use status and socio-demographic characteristics such as sex, age, race/color, region, household location and schooling. Materials and methods: A multivariable analysis was carried out using data from the Global Adult Tobacco Survey in 2008 and the National Health Survey in 2013. Results: Both surveys showed that among nonsmokers: women, young adults and those who had over 10 years of schooling had more frequently noticed advertising of cigarettes at point of sale...
2017: Salud Pública de México
https://www.readbyqxmd.com/read/28658359/the-influence-of-sagittal-position-of-the-mandible-in-facial-attractiveness-and-social-perception
#17
Lorena Marques Ferreira de Sena, Lislley Anne Lacerda Damasceno E Araújo, Arthur Costa Rodrigues Farias, Hallissa Simplício Gomes Pereira
OBJECTIVE: This study aims at comparing the perception of orthodontists, maxillofacial surgeons, visual artists and laypersons when evaluating the influence of sagittal position of the mandible - in lateral view - in facial attractiveness; at a job hiring; and in the perception of socioeconomic profile. METHODS: A black male, a white male, a black female and a white female with harmonic faces served as models to obtain a facial profile photograph. Each photograph was digitally manipulated to obtain seven facial profiles: an ideal, three simulating mandibular advancement and three simulating mandibular retrusion, producing 28 photographs...
March 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28658330/transaxillary-single-port-subtotal-parathyroidectomy-feasibility-study-in-cadavers
#18
Alexandre Elmães de Marsillac, Rossano Kepler Alvim Fiorelli, Henrique Neubarth Phillips, Pietro Novellino, André Lacerda Oliveira, Ricardo Paiva A Scheiba Zorron
Objective : to test the minimally invasive technique of single-port transaxillary subtotal parathyroidectomy in non-formalized cadavers to evaluate its viability and reproduction. Method : we performed ten subtotal parathyroidectomies through a transaxillary TriPort access in cadavers. The technique consisted of access through the axillary fossa, creating a subcutaneous tunnel to the anterior cervical region, for handling of the thyroid gland and dissection and resection of the parathyroid glands...
March 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28654470/team-approach-pyomyositis
#19
John F Lovejoy, Kenneth Alexander, David Dinan, Dennis Drehner, Nazeema Khan-Assad, Iara R A Lacerda
No abstract text is available yet for this article.
June 2017: JBJS Reviews
https://www.readbyqxmd.com/read/28649428/the-uk-me-cfs-biobank-for-biomedical-research-on-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-and-multiple-sclerosis
#20
Eliana M Lacerda, Erinna W Bowman, Jacqueline M Cliff, Caroline C Kingdon, Elizabeth C King, Ji-Sook Lee, Taane G Clark, Hazel M Dockrell, Eleanor M Riley, Hayley Curran, Luis Nacul
The UK ME/CFS Biobank was launched in August 2011 following extensive consultation with professionals and patient representatives. The bioresource aims to enhance research on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), related to pathophysiology, biomarkers and therapeutic approaches. The cohort includes 18-60 year olds, encompassing 284 clinically-confirmed ME/CFS cases, 60 neurologist-diagnosed multiple sclerosis (MS) cases, and 135 healthy individuals. The Biobank contains blood samples, aliquoted into serum, plasma, peripheral blood mononuclear cells (PBMC), red blood cells/granulocyte pellet, whole blood, and RNA (totalling 29,863 aliquots)...
2017: Open J Bioresour
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