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https://www.readbyqxmd.com/read/28633629/prevalence-of-and-risk-factors-for-severe-cognitive-and-sleep-symptoms-in-me-cfs-and-ms
#1
Vageesh Jain, Amit Arunkumar, Caroline Kingdon, Eliana Lacerda, Luis Nacul
BACKGROUND: There are considerable phenotypic and neuroimmune overlaps between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and multiple sclerosis (MS). While the precise aetiologies of both MS and ME/CFS are unclear, evidence suggests that deterioration in cognitive function is widely prevalent in patients with either condition. Little is known about differing risk factors or exposures, which may lead to severe cognitive or sleep symptoms. This study aims to gauge the extent of cognitive and sleep symptoms in ME/CFS and MS patients participating in the UK ME/CFS Biobank and identify the characteristics of those experiencing severe symptoms...
June 20, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28632748/trimetazidine-therapy-for-diabetic-mouse-hearts-subjected-to-ex-vivo-acute-heart-failure
#2
Emilene Breedt, Lydia Lacerda, M Faadiel Essop
Acute heart failure (AHF) is the most common primary diagnosis for hospitalized heart diseases in Africa. As increased fatty acid β-oxidation (FAO) during heart failure triggers detrimental effects on the myocardium, we hypothesized that trimetazidine (TMZ) (partial FAO inhibitor) offers cardioprotection under normal and obese-related diabetic conditions. Hearts were isolated from 12-14-week-old obese male and female diabetic (db/db) mice versus lean non-diabetic littermates (db/+) controls. The Langendorff retrograde isolated heart perfusion system was employed to establish an ex vivo AHF model: a) Stabilization phase-Krebs Henseleit buffer (10 mM glucose) at 100 mmHg (25 min); b) Critical Acute Heart Failure (CAHF) phase-(1...
2017: PloS One
https://www.readbyqxmd.com/read/28629754/improving-compliance-with-surgical-antibiotic-prophylaxis-guidelines-a-multicenter-evaluation
#3
Cristiane Schmitt, Rubia Aparecida Lacerda, Ruth Natalia Teresa Turrini, Maria Clara Padoveze
BACKGROUND: Improving surgical antibiotic prophylaxis (SAP) use is an important element in the control of antimicrobial resistance. However, compliance with SAP guidelines is unsatisfactory. This study investigated the level of compliance with SAP guidelines in neurosurgery, and institutional characteristics associated with compliance. METHODS: This study assessed surgeries in 9 Brazilian hospitals. Medical record reviews and a structured questionnaire were used to assess compliance and to describe institutional characteristics...
June 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28625550/maternal-exposure-to-western-diet-affects-adult-body-composition-and-voluntary-wheel-running-in-a-genotype-specific-manner-in-mice
#4
Layla Hiramatsu, Jarren Kay, Zoe Thompson, Jennifer Singleton, Gerald Claghorn, Ralph Lacerda de Albuquerque, Brittany Ho, Brett Ho, Gabriela Sanchez, Theodore Garland
Some human diseases, including obesity, Type II diabetes, and numerous cancers, are thought to be influenced by environments experienced in early life, including in utero. Maternal diet during the perinatal period may be especially important for adult offspring energy balance, potentially affecting both body composition and physical activity. This effect may be mediated by the genetic background of individuals, including, for example, potential "protective" mechanisms for individuals with inherently high levels of physical activity or high basal metabolic rates...
June 15, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28620766/phenotype-transformation-of-aortic-valve-interstitial-cells-due-to-applied-shear-stresses-within-a-microfluidic-chip
#5
Xinmei Wang, Joohyung Lee, Mir Ali, Jungkyu Kim, Carla M R Lacerda
Despite valvular heart diseases constituting a significant medical problem, the acquisition of information describing their pathophysiology remains difficult. Due to valvular size, role and location within the body, there is a need for in vitro systems that can recapitulate disease onset and progression. This study combines the development of an in vitro model and its application in the mechanical stimulation of valvular cell transformation. Specifically, porcine aortic valvular interstitial cells (PAVIC) were cultured on polydimethylsiloxane microfluidic devices with or without exposure to shear stresses...
June 15, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28614503/user-satisfaction-with-primary-health-care-by-region-in-brazil-1st-cycle-of-external-evaluation-from-pmaq-ab
#6
Ane Polline Lacerda Protasio, Luciano Bezerra Gomes, Liliane Dos Santos Machado, Ana Maria Gondim Valença
The National Program for Access and Quality Improvement in Primary Care (Programa Nacional de Melhoria do Acesso e da Qualidade da Atenção Básica, PMAQ-AB) aimed to improve healthcare public service quality and satisfaction of health service users. This study's objective was to identify the main factors influencing user satisfaction with primary care (PC) services by region in Brazil. Using secondary data from the 1st Cycle of PMAQ-AB, logistic regression models were developed by region, with user satisfaction as the dependent variable, as defined by cluster analysis...
June 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28614161/multiple-cerebral-infarcts-in-a-young-patient-associated-with-marijuana-use
#7
Leila Costa Volpon, Camila Lacerda Muniz de Melo Sousa, Silvia Keiko Kavaguti Moreira, Sara Reis Teixeira, Ana Paula de Carvalho Panzeri Carlotti
: Cerebrovascular events associated with marijuana use have been reported previously. This association is plausible, but not well-established yet. A 14-year-old girl, long-term heavy cannabis user, presented with generalized tonic-clonic seizures and decreased level of consciousness a few hours after smoking cannabis. Brain magnetic resonance imaging showed multiple areas of acute, subacute and chronic ischemic lesions in the left frontal lobe, basal ganglia, and corpus callosum. History of other illicit drug use and other known causes of stroke were ruled out...
June 13, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28610162/revalidation-of-i-platystigma-i-kennedy-1920-with-a-synopsis-of-the-i-quadratum-i-species-group-and-the-description-of-three-new-species-odonata-pseudostigmatidae
#8
Angelo B M Machado, Déborah S Soldati Lacerda
The genus Platystigma Kennedy, 1920 is revalidated based mainly on the third segment of the penis that is plate-like, whereas in the other Pseudostigmatidae it is a flagellum. Dijkstra et al (2014) have merged this family into the Coenagrionidae. However, we prefer to maintain the long-used name Pseudostigmatidae until more detailed phylogenetic studies with more sampling are done. Eight species are here considered in the genus, three of which are described as new: P. humaita, P. minimum and P. quadratum. The genus is divided in two species group, jocaste and quadratum, the latter studied here...
March 13, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609914/a-new-caprellid-species-crustacea-amphipoda-senticaudata-from-brazil
#9
Macarena Ros, Mariana B Lacerda, José M Guerra-García
A new species of caprellid, Pseudaeginella arraialensis, is described from Arraial do Cabo, Rio de Janeiro, Brazil. Abundant material was collected in Praia do Forno, associated to hydroids and algae of natural rocky substrata and fouling communities of artificial floating structures. The new species can be distinguished easily from the remaining species in the genus mainly by the pattern of dorsal projections, and by the setose antennae and gnathopod 2 in males. The dietary analysis revealed that the species is omnivorous, with a high contribution of small crustaceans in its diet...
May 1, 2017: Zootaxa
https://www.readbyqxmd.com/read/28602961/progress-and-biotechnological-prospects-in-fish-transgenesis
#10
REVIEW
Fernanda M P Tonelli, Samyra M S N Lacerda, Flávia C P Tonelli, Guilherme M J Costa, Luiz Renato de França, Rodrigo R Resende
The history of transgenesis is marked by milestones such as the development of cellular transdifferentiation, recombinant DNA, genetic modification of target cells, and finally, the generation of simpler genetically modified organisms (e.g. bacteria and mice). The first transgenic fish was developed in 1984, and since then, continuing technological advancements to improve gene transfer have led to more rapid, accurate, and efficient generation of transgenic animals. Among the established methods are microinjection, electroporation, lipofection, viral vectors, and gene targeting...
June 8, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28598340/effects-of-drinking-desalinated-seawater-on-cell-viability-and-proliferation
#11
Camila Longhi Macarrão, André Luis Lacerda Bachi, Mario Mariano, Lucia Jamli Abel
Desalination of seawater is becoming an important means to address the increasing scarcity of freshwater resources in the world. Seawater has been used as drinking water in the health, food, and medical fields and various beneficial effects have been suggested, although not confirmed. Given the presence of 63 minerals and trace elements in drinking desalinated seawater (63 DSW), we evaluated their effects on the behavior of tumorigenic and nontumorigenic cells through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and annexin-V-fluorescein isothiocyanate/propidium iodide staining...
June 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/28598250/telehealth-centers-a-proposal-of-a-theoretical-model-for-evaluation
#12
Luana Gabriele Nilson, Luise Lüdke Dolny, Sônia Natal, Josimari Telino de Lacerda, Maria Cristina Marino Calvo
BACKGROUND: Telehealth is a form of assistance support and continuing education for professionals who work in Primary Healthcare. INTRODUCTION: The implementation of the Brazilian Telehealth Program has extended the need for evaluation of its results to improve its use and benefits. Thus, it is necessary to systematize the theory, principals, and guidelines that guide the program organization, its activities, and resources. The objective of this study is to propose a theoretical model of functioning and organization for telehealth centers of the Brazilian Telehealth Program...
June 9, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28595183/association-between-leptin-adiponectin-and-leptin-adiponectin-ratio-with-clustered-metabolic-risk-factors-in-portuguese-adolescents-the-labmed-physical-activity-study
#13
César A Agostinis-Sobrinho, Edmar Lacerda Mendes, Carla Moreira, Sandra Abreu, Luís Lopes, José Oliveira-Santos, Albertas Skurvydas, Jorge Mota, Rute Santos
INTRODUCTION: Circulating leptin and adiponectin levels have been associated with impaired vascular function, insulin resistance, and acute cardiovascular evens. This study aimed to evaluate the associations of leptin, adiponectin, and the leptin/adiponectin (L/A) ratio with a clustering of metabolic risk factors (MRF) in adolescents aged 12-18 years. METHODS: This is a cross-sectional analysis with 529 Portuguese adolescents aged 12-18 years. Blood samples were taken to analyze total cholesterol (TC) and high-density lipoprotein (HDL) cholesterol (HDL-c), triglycerides glucose, insulin, leptin, and adiponectin levels...
June 9, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28593475/functional-metagenomics-of-oil-impacted-mangrove-sediments-reveals-high-abundance-of-hydrolases-of-biotechnological-interest
#14
Júlia Ronzella Ottoni, Lucélia Cabral, Sanderson Tarciso Pereira de Sousa, Gileno Vieira Lacerda Júnior, Daniela Ferreira Domingos, Fábio Lino Soares Junior, Mylenne Calciolari Pinheiro da Silva, Joelma Marcon, Armando Cavalcante Franco Dias, Itamar Soares de Melo, Anete Pereira de Souza, Fernando Dini Andreote, Valéria Maia de Oliveira
Mangroves are located in coastal wetlands and are susceptible to the consequences of oil spills, what may threaten the diversity of microorganisms responsible for the nutrient cycling and the consequent ecosystem functioning. Previous reports show that high concentration of oil favors the incidence of epoxide hydrolases and haloalkane dehalogenases in mangroves. This finding has guided the goals of this study in an attempt to broaden the analysis to other hydrolases and thereby verify whether oil contamination interferes with the prevalence of particular hydrolases and their assigned microorganisms...
July 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28566098/fish-parasites-as-indicators-of-organic-pollution-in-southern-brazil
#15
A C F Lacerda, K Roumbedakis, J G S Bereta Junior, A P O Nuñer, M M Petrucio, M L Martins
Increasing urbanization along riverbanks is a constant source of stressors to the aquatic community, and the use of bioindicators is suitable to detect and monitor the effect of each stressor. We investigated the parasites of the 'cará' fish (Geophagus brasiliensis) as potential bioindicators in a river whose banks are subject to increasing anthropogenic pressure. Samples were taken at four points of the Sangradouro River, in Florianópolis, southern Brazil, bimonthly for 12 months. Water temperature, pH, dissolved oxygen, conductivity and salinity were measured at each point and water samples were taken for nutrient analysis (total nitrogen, nitrite, total ammonia nitrogen, total phosphorus, phosphate), and total and faecal coliforms...
June 1, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28562797/integrality-of-care-challenges-for-the-nurse-practice
#16
Solange Meira de Sousa, Elizabeth Bernardino, Karla Crozeta, Aida Maris Peres, Maria Ribeiro Lacerda
Objective: to understand the role of the nurse in the collegiate management model of a teaching hospital, in the integrality of care perspective. Method: a single case study with multiple units of analysis, with the theoretical proposition "integrality of care is a result of the care offered to the user by multiple professionals, including the nurse". Data were obtained in a functional unit of a teaching hospital through interviews with 13 nurses in a non-participant observation and document analysis...
May 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28562786/structure-dynamics-of-a-fish-community-over-ten-years-of-formation-in-the-reservoir-of-the-hydroelectric-power-plant-in-upper-uruguay-river
#17
G Schork, E Zaniboni-Filho
The objective of this study was to evaluate the structure of the fish assemblage in the ten years following the closing of the lake of the Itá Hydroelectric Power Plant. Seasonal collections were conducted from 2001 to 2010. During this period, 44,834 fish were captured, totaling 3,818.01 kg, among 8 orders, 24 families and 84 species. In general, profound changes were not observed in the fish assemblage in the ten years after the formation of the Itá lake. Few species changed in dominance over time, while many were rare in the environment...
May 25, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28562766/wuchereria-bancrofti-infection-in-haitian-immigrants-and-the-risk-of-re-emergence-of-lymphatic-filariasis-in-the-brazilian-amazon
#18
Edson Fidelis da Silva, Marcus Vinícius Guimarães de Lacerda, Gilberto Fontes, Maria Paula Gomes Mourão, Marilaine Martins
INTRODUCTION: Lymphatic filariasis (LF) is a public health problem in Haiti. Thus, the emigration of Haitians to Brazil is worrisome because of the risk for LF re-emergence. METHODS: Blood samples of Haitian immigrants, aged ≥18 years, who emigrated to Manaus (Brazilian Amazon), were examined using thick blood smears, membrane blood filtration, and immunochromatography. RESULTS: Of the 244 immigrants evaluated, 1 (0.4%) tested positive for W...
March 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28562748/implications-of-snps-on-toll-like-receptor-genes-in-malaria-what-do-we-know
#19
EDITORIAL
Allyson Guimarães Costa, Rajendranath Ramasawmy, Adriana Malheiro, Marcus Vinícius Guimarães Lacerda
No abstract text is available yet for this article.
March 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28554971/the-67p-churyumov-gerasimenko-observation-campaign-in-support-of-the-rosetta-mission
#20
C Snodgrass, M F A'Hearn, F Aceituno, V Afanasiev, S Bagnulo, J Bauer, G Bergond, S Besse, N Biver, D Bodewits, H Boehnhardt, B P Bonev, G Borisov, B Carry, V Casanova, A Cochran, B C Conn, B Davidsson, J K Davies, J de León, E de Mooij, M de Val-Borro, M Delacruz, M A DiSanti, J E Drew, R Duffard, N J T Edberg, S Faggi, L Feaga, A Fitzsimmons, H Fujiwara, E L Gibb, M Gillon, S F Green, A Guijarro, A Guilbert-Lepoutre, P J Gutiérrez, E Hadamcik, O Hainaut, S Haque, R Hedrosa, D Hines, U Hopp, F Hoyo, D Hutsemékers, M Hyland, O Ivanova, E Jehin, G H Jones, J V Keane, M S P Kelley, N Kiselev, J Kleyna, M Kluge, M M Knight, R Kokotanekova, D Koschny, E A Kramer, J J López-Moreno, P Lacerda, L M Lara, J Lasue, H J Lehto, A C Levasseur-Regourd, J Licandro, Z Y Lin, T Lister, S C Lowry, A Mainzer, J Manfroid, J Marchant, A J McKay, A McNeill, K J Meech, M Micheli, I Mohammed, M Monguió, F Moreno, O Muñoz, M J Mumma, P Nikolov, C Opitom, J L Ortiz, L Paganini, M Pajuelo, F J Pozuelos, S Protopapa, T Pursimo, B Rajkumar, Y Ramanjooloo, E Ramos, C Ries, A Riffeser, V Rosenbush, P Rousselot, E L Ryan, P Santos-Sanz, D G Schleicher, M Schmidt, R Schulz, A K Sen, A Somero, A Sota, A Stinson, J M Sunshine, A Thompson, G P Tozzi, C Tubiana, G L Villanueva, X Wang, D H Wooden, M Yagi, B Yang, B Zaprudin, T J Zegmott
We present a summary of the campaign of remote observations that supported the European Space Agency's Rosetta mission. Telescopes across the globe (and in space) followed comet 67P/Churyumov-Gerasimenko from before Rosetta's arrival until nearly the end of the mission in September 2016. These provided essential data for mission planning, large-scale context information for the coma and tails beyond the spacecraft and a way to directly compare 67P with other comets. The observations revealed 67P to be a relatively 'well-behaved' comet, typical of Jupiter family comets and with activity patterns that repeat from orbit to orbit...
July 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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