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https://www.readbyqxmd.com/read/29351550/differential-actions-of-ppar-%C3%AE-and-ppar-%C3%AE-%C3%AE-on-beige-adipocyte-formation-a-study-in-the-subcutaneous-white-adipose-tissue-of-obese-male-mice
#1
Tamiris Lima Rachid, Flavia Maria Silva-Veiga, Francielle Graus-Nunes, Isabele Bringhenti, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello
BACKGROUND AND AIMS: Obesity compromises adipocyte physiology. PPARs are essential to adipocyte plasticity, but its isolated role in the browning phenomenon is not clear. This study aimed to examine whether activation of PPAR-α or PPAR-β/δ could induce beige cell depots in the subcutaneous white adipose tissue of diet-induced obese mice. MATERIAL AND METHODS: Sixty animals were randomly assigned to receive a control diet (C, 10% lipids) or a high-fat diet (HF, 50% lipids) for ten weeks...
2018: PloS One
https://www.readbyqxmd.com/read/29343263/knowledge-use-and-disuse-of-unconventional-food-plants
#2
Mayana Lacerda Leal, Rubana Palhares Alves, Natalia Hanazaki
BACKGROUND: People's diets are usually restricted to a small number of plant species, even in regions with great diversity. We investigated the knowledge of residents in Ribeirão da Ilha, a district of Florianópolis (Santa Catarina, Brazil), about unconventional food plants (UFP). We report the UFP of the region, the parts used, the methods of processing, and the reasons for reduced use or even lack of use. METHODS: From June 2014 to January 2015, we interviewed 26 long-established residents and made free listings of plant resources in the region...
January 17, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29340489/tuberculosis-infection-among-primary-health-care-workers
#3
Thamy Carvalho Lacerda, Fernanda Mattos de Souza, Thiago Nascimento do Prado, Rodrigo Leite Locatelli, Geisa Fregona, Rita de Cássia Duarte Lima, Ethel Leonor Maciel
OBJECTIVE: To estimate the prevalence of and determine the risk factors associated with latent Mycobacterium tuberculosis infection (LTBI) among primary health care workers in the city of Vitória, Brazil. METHODS: This was a cross-sectional study with data collected through a survey regarding socio-demographic, occupational, clinical, and exposure characteristics, as well as knowledge about tuberculosis, conducted between 2011 and 2012. All participants underwent a tuberculin skin test (TST), and TSTs were read at 72 h by a trained professional...
November 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29324958/enhancing-the-process-of-teaching-and-learning-homecare
#4
Ana Paula Hermann, Maria Ribeiro Lacerda, Jaqueline Dias do Nascimento, Ingrid Meireles Gomes, Débora Cristina Paes Zatoni
OBJECTIVE: to identify possibilities for improvement in the process of teaching and learning homecare in nursing, pharmacy, medicine, nutrition, dentistry and occupational therapy courses. METHOD: qualitative research using the Grounded Theory approach. Sixty-three semi-structured interviews were conducted with students, teachers and graduates of the six mentioned courses at a public university in the south of Brazil. Data analysis was performed through open, axial and selective coding...
January 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29323413/extracorporeal-membrane-oxygenation-for-refractory-severe-respiratory-failure-in-acute-interstitial-pneumonia
#5
Gabriela Gonçalves-Venade, Nuno Lacerda-Príncipe, Roberto Roncon-Albuquerque, José Artur Paiva
Acute interstitial pneumonia (AIP) is a rare idiopathic interstitial lung disease with rapid progressive respiratory failure and high mortality. In the present report, three cases of AIP complicated by refractory respiratory failure supported with extracorporeal membrane oxygenation (ECMO) are presented. One male and two female patients (ages 27-59) were included. Venovenous ECMO support was provided using miniaturized systems, with two-site femoro-jugular circuit configuration. Despite lung protective ventilation, prone position and neuromuscular blockade, refractory respiratory failure of unknown etiology supervened (ratio of arterial oxygen partial pressure to fractional inspired oxygen 46-130) and ECMO was initiated after 3-7 days of mechanical ventilation...
January 11, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29322345/freshwater-shrimps-macrobrachium-depressimanum-and-macrobrachium-jelskii-as-biomonitors-of-hg-availability-in-the-madeira-river-basin-western-amazon
#6
R C F Galvão, I B B Holanda, D P De Carvalho, R Almeida, C M M Souza, L D Lacerda, W R Bastos
Total mercury (THg) concentrations measured in two freshwater shrimp species (Macrobrachium depressimanum and Macrobrachium jelskii) showed a relationship with the location of artisanal and small-scale gold mining (ASGM) from the Madeira River Basin, Western Amazon. Between August 2009 and May 2010, 212 shrimp samples were collected in the confluence of the Madeira River with three of its tributaries (Western Amazon). THg concentration was quantified in the exoskeleton, hepatopancreas and muscle tissue of the shrimps by cold vapor atomic absorption spectrophotometry...
January 10, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29319739/translation-cultural-adaptation-and-validation-of-the-diabetes-attitudes-scale-third-version-into-brazilian-portuguese
#7
Gisele de Lacerda Chaves Vieira, Adriana Silvino Pagano, Ilka Afonso Reis, Júlia Santos Nunes Rodrigues, Heloísa de Carvalho Torres
OBJECTIVE: to perform the translation, adaptation and validation of the Diabetes Attitudes Scale - third version instrument into Brazilian Portuguese. METHODS: methodological study carried out in six stages: initial translation, synthesis of the initial translation, back-translation, evaluation of the translated version by the Committee of Judges (27 Linguists and 29 health professionals), pre-test and validation. The pre-test and validation (test-retest) steps included 22 and 120 health professionals, respectively...
January 8, 2018: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29319731/comparison-among-bone-marrow-mesenchymal-stem-and-mononuclear-cells-to-promote-functional-recovery-after-spinal-cord-injury-in-rabbits
#8
Antônio Filipe Braga Fonseca, Jussara Peters Scheffer, Arthur Giraldi-Guimarães, Bárbara Paula Coelho, Raphael Mansur Medina, André Lacerda Abreu Oliveira
PURPOSE: To investigate the efficacy of allogeneic mesenchymal stem-cells and autologous mononuclear cells to promote sensorimotor recovery and tissue rescue. METHODS: Female rabbits were submitted to the epidural balloon inflation method and the intravenous cells administrations were made after 8 hours or seven days after injury induction. Sensorimotor evaluation of the hindlimbs was performed, and the euthanasia was made thirty days after the treatment. Spinal cords were stained with hematoxylin and eosin...
December 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29316918/in-silico-epitope-mapping-and-experimental-evaluation-of-the-merozoite-adhesive-erythrocytic-binding-protein-maebl-as-a-malaria-vaccine-candidate
#9
Pedro Cravo, Renato B Machado, Juliana A Leite, Taizy Leda, Rossarin Suwanarusk, Najara Bittencourt, Letusa Albrecht, Carla Judice, Stefanie C P Lopes, Marcus V G Lacerda, Marcelo U Ferreira, Irene S Soares, Yun Shan Goh, Daniel Y Bargieri, François Nosten, Bruce Russell, Laurent Rénia, Fabio T M Costa
BACKGROUND: Technical limitations for culturing the human malaria parasite Plasmodium vivax have impaired the discovery of vaccine candidates, challenging the malaria eradication agenda. The immunogenicity of the M2 domain of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) antigen cloned from the Plasmodium yoelii murine parasite, has been previously demonstrated. RESULTS: Detailed epitope mapping of MAEBL through immunoinformatics identified several MHCI, MHCII and B cell epitopes throughout the peptide, with several of these lying in the M2 domain and being conserved between P...
January 10, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29306074/association-between-developmental-defects-of-enamel-and-celiac-disease-a-meta-analysis
#10
REVIEW
Débora Souto-Souza, Maria Eliza da Consolação Soares, Vanessa Silva Rezende, Paulo César de Lacerda Dantas, Endi Lanza Galvão, Saulo Gabriel Moreira Falci
OBJECTIVES: Studies have observed the presence of extra-intestinal manifestations of celiac disease (CD), including involvement of the oral cavity, such that developmental defects of enamel (DDE) occur. Thus, the aim of this review was to access the polled prevalence of DDE in individuals with CD, and to establish the strength of the association between these two variables. METHODS: To carry out the systematic review, four electronic databases and the Grey Literature were searched, complemented by a manual search of reference lists within the selected articles...
December 28, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29303860/mandibular-osteonecrosis-associated-with-raloxifene
#11
Hélder Antônio Rebelo Pontes, Lucas Lacerda de Souza, Daniel Cavalléro Colares Uchôa, João Mateus Mendes Cerqueira
Osteonecrosis is a disease with diverse pathophysiology, clinical presentation, and management. It may be associated with some medications used to treat systemic issues with bone metabolism. A few cases of jaw bone osteonecrosis have been associated with raloxifene. In this paper, the authors present a clinical report of a 64-year-old woman who presented with a necrosis foci in the right alveolar ridge of the mandible, associated with continued raloxifene use.
January 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29297949/effect-of-17-allylamino-17-demethoxygeldanamycin-17-aag-on-akt-protein-expression-is-more-effective-in-head-and-neck-cancer-cell-lineages-that-retain-pten-protein-expression
#12
Flávia Sirotheau Corrêa Pontes, Hélder Antônio Rebelo Pontes, Lucas Lacerda de Souza, Adriana Souza de Jesus, Andrea Maia Correa Joaquim, Ligia Akiko Ninokata Miyahara, Felipe Paiva Fonseca, Décio Dos Santos Pinto Júnior
OBJECTIVES: The aim of this study was to evaluate the expression of Akt, PTEN, Mdm2 and p53 proteins in three different head and neck squamous cell carcinoma (HNSCC) cell lines (HN6, HN19 and HN30), all of them treated with epidermal growth factor (EGF) and 17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of Hsp90 protein. MATERIAL AND METHODS: Immunofluorescence and western blot were performed in order to analyze the location and quantification, respectively, of proteins under the action 17-AAG and EGF...
January 3, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29297842/sterilization-of-hybrid-marmoset-callithrix-sp-females-an-evaluation-of-two-surgical-methods
#13
Fábio Ferreira de Queiroz, Giane Chaves Kristosch, Flávio Landim Soffiati, Mônica Jorge Luz, André Lacerda de Abreu Oliveira, Tânia Ribeiro Junqueira Borges, Carlos Ramón Ruiz Miranda, Leonardo Serafim da Silveira
Population control techniques, either permanent or reversible, are important tools for the management of wildlife in captive and natural environments. Among these, surgical sterilization provides a permanent solution to unwanted reproduction. Surgical techniques can differ in their invasiveness and in the subsequent effect on behavior and physiology. For social animals, techniques that preserve gonads, such as vasectomy for males and ligation of uterine tubes for females, may be preferred because they maintain important physiology that influences behavior...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29286970/a-child-with-a-rare-extraosseous-extension-and-pathologic-fracture-from-a-vertebral-hemangioma-a-case-report
#14
Pawin Gajaseni, Luca Labianca, Iara Lacerda, Stuart Weinstein
CASE: We present a case of a pathologic vertebral fracture and encroachment into the spinal canal from a vertebral hemangioma in a 13-year-old boy. The original approach of embolization followed by an anterior-posterior resection and stabilization through a costotransversectomy had to be converted intraoperatively to a combined anterior and posterior approach secondary to excessive bleeding. CONCLUSION: Because of the hypervascularity and the extensive nature of aggressive vertebral hemangiomas, surgeons attempting procedures similar to the case described herein must be prepared to adapt to the circumstances when preoperative embolization is not totally effective...
October 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29282130/what-does-not-kill-it-makes-it-weaker-effects-of-sub-lethal-concentrations-of-ivermectin-on-the-locomotor-activity-of-anopheles-aquasalis
#15
Vanderson de Souza Sampaio, Gustavo Bueno da Silva Rivas, Kevin Kobylinski, Yudi Tatiana Pinilla, Paulo Filemon Paolluci Pimenta, José Bento Pereira Lima, Rafaela Vieira Bruno, Marcus Vinícius Guimarães Lacerda, Wuelton Marcelo Monteiro
BACKGROUND: Malaria remains a major public health concern. Vector control measures based solely on insecticide treated nets (ITNs) and indoor residual spraying (IRS) have demonstrated not to be feasible for malaria elimination. It has been shown that ivermectin affects several aspects of Anopheles species biology. Along the Latin American seacoast, Anopheles aquasalis Curry plays an important role in malaria transmission. The observation of mosquitoes locomotor activity under laboratory conditions can reveal details of their daily activity rhythms, which is controlled by an endogenous circadian clock that seems to be influenced by external signals, such as light and temperature...
December 28, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29280659/prevalence-of-hypovitaminosis-d-and-associated-factors-in-adolescent-students-of-a-capital-of-northeastern-brazil
#16
Euarda Pontes Dos Santos Araújo, Dayanna Joyce Marques Queiroz, Juliana Padilha Ramos Neves, Lavoisiana Mateus de Lacerda, Maria Da Conceição Rodrigues Gonçalves, Alice Teles de Carvalho
BACKGROUND: Hypovitaminosis D is a frequent problem in the world and can be influenced by several factors. OBJECTIVE: To estimate the prevalence of hypovitaminosis D and associated factors in adolescent students of a capital city of northeastern Brazil. METHODS: Cross-sectional epidemiological study assessing 220 school adolescents of both sexes aged 15 to 19 years. A questionnaire was applied to assess sociodemographic (skin color, mother's education and receiving social benefits) and behavioral data (number of hours of sleep per day, sun exposure, physical activity and dietary vitamin D intake)...
November 16, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29280433/cd45ro-t-cells-and-t-cell-activation-in-the-long-lasting-immunity-after-leishmania-infantum-infection
#17
João F Rodrigues-Neto, Gloria R Monteiro, Tatjana S L Keesen, Henio G Lacerda, Edgar M Carvalho, Selma M B Jeronimo
Manifestations of Leishmania infantum infection range from asymptomatic to symptomatic visceral leishmaniasis (VL). People with symptomatic VL (sVL) have suppressed immune responses against Leishmania antigens that are reversed after clinical cure. The intradermal leishmanin skin test (LST) is negative during sVL, but it becomes positive after treatment. The aim of this study was to compare T cell responses in individuals with sVL, recovered VL (RecVL), and endemic controls. Endemic controls were household contacts of a VL case and they were grouped by their LST results, either positive (LST+) or negative (LST-)...
December 26, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29279067/-breast-cancer-value-based-healthcare-costs-and-financing
#18
Ana Harfouche, Silvia Silva, João Faria, Rui Araújo, António Gouveia, Maria Lacerda, Luís D'Orey
INTRODUCTION: Breast cancer is the second most common oncological disease worldwide. To analyse the new disease specific funding programme (breast cancer) implemented at the Francisco Gentil Portuguese Institute of Oncology, Lisbon Center (Instituto Português de Oncologia de Lisboa Francisco Gentil), the actual costs of the patients were examined using activity-based costing as a costing methodology. This study addresses the following question: "How much does it cost to treat breast cancer per 'patient-month' compared to the monthly fixed 'funding envelope'?"...
November 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29273053/are-respiratory-complications-of-plasmodium-vivax-malaria-an-underestimated-problem
#19
Fernando Val, Sara Avalos, André Alexandre Gomes, José Evelio Albornoz Zerpa, Gustavo Fontecha, André Machado Siqueira, Quique Bassat, Maria Graças Costa Alecrim, Wuelton Marcelo Monteiro, Marcus Vinícius Guimarães Lacerda
BACKGROUND: Respiratory complications are uncommon, but often life-threatening features of Plasmodium vivax malaria. This study aimed to estimate the prevalence and lethality associated with such complications among P. vivax malaria patients in a tertiary hospital in the Western Brazilian Amazon, and to identify variables associated with severe respiratory complications, intensive care need and death. Medical records from 2009 to 2016 were reviewed aiming to identify all patients diagnosed with P...
December 22, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29273020/trends-in-cause-and-place-of-death-for-children-in-portugal-a-european-country-with-no-paediatric-palliative-care-during-1987-2011-a-population-based-study
#20
Ana Forjaz de Lacerda, Barbara Gomes
BACKGROUND: Children and adolescents dying from complex chronic conditions require paediatric palliative care. One aim of palliative care is to enable a home death if desired and well supported. However, there is little data to inform care, particularly from countries without paediatric palliative care, which constitute the majority worldwide. METHODS: This is an epidemiological study analysing death certificate data of decedents aged between 0 and 17 years in Portugal, a developed Western European country without recognised provision of paediatric palliative care, from 1987 to 2011...
December 22, 2017: BMC Pediatrics
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