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https://www.readbyqxmd.com/read/28425875/occurrence-of-qnrb1-and-qnrb12-genes-mutation-in-gyra-and-ramr-and-expression-of-efflux-pumps-in-isolates-of-klebsiella-pneumoniae-carriers-of-blakpc-2
#1
Alexsandra Maria Lima Scavuzzi, Maria Amélia Vieira Maciel, Heloísa Ramos Lacerda de Melo, Luiz Carlos Alves, Fábio André Brayner, Ana Catarina Souza Lopes
PURPOSE: The occurrence of quinolone-resistance genes (qnrA, qnrB and qnrS), the presence of mutations in gyrA, gyrB and parC, as well as the expression of efflux pumps (acrB and acrF) and mutations in the gene ramR. METHODOLOGY: Were investigated in 30 blaKPC-2-positive isolates of Klebsiella pneumoniae taken from infection and colonization in hospital patients from Recife-PE, Brazil. The detection of the qnr, acrB and acrF genes and analysis of the mutations in ramR and the quinolone-resistance-determining regions of gyrA, gyrB and parC were performed by PCR followed by DNA sequencing...
April 21, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28425872/increase-in-human-immunodeficiency-virus-1-diversity-and-detection-of-various-subtypes-and-recombinants-in-north-eastern-brazil
#2
Kledoaldo Lima, Élcio Leal, Ana Maria Salustiano Cavalcanti, Daniela Medeiros Salustiano, Luzidalva Barbosa de Medeiros, Sirleide Pereira da Silva, Heloísa Ramos Lacerda
PURPOSE: Diverse human immunodeficiency virus 1 (HIV-1) subtypes and circulating recombinant forms are found in Brazil. The majority of HIV-1 molecular epidemiological studies in Brazil have been conducted in the southern and south-eastern regions of the country, although several recent studies in the north-eastern region have addressed this issue. The objective of this study was to molecularly characterize HIV-1 circulating in Pernambuco, north-eastern Brazil. METHODOLOGY: A total of 64 samples were collected from 2002 to 2003, and another 103 were collected from 2007 to 2009...
April 21, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28422366/oral-paracoccidioidomycosis-retrospective-analysis-of-55-brazilian-patients
#3
Aline Heloísa Trindade, Henrique Côrtes Meira, Igor Figueiredo Pereira, Julio César Tanos de Lacerda, Ricardo Alves de Mesquita, Vagner Rodrigues Santos
Paracoccidioidomycosis (PCM) is a rare fungal infection in the world, but endemic and acquired exclusively in Latin America, with the highest prevalence in South America and Brazil, particularly. Changes in oral cavity are common and constitute the first clinical manifestation in many patients. The aim of this study was to describe the prevalence of oral PCM and analyse the profile of the disease and patients. Retrospective research, consisting of information present in the medical records in the period 1998-2015, whose histopathological diagnosis was oral PCM...
April 19, 2017: Mycoses
https://www.readbyqxmd.com/read/28420735/correction-the-soluble-pattern-recognition-receptor-ptx3-links-humoral-innate-and-adaptive-immune-responses-by-helping-marginal-zone-b-cells
#4
Alejo Chorny, Sandra Casas-Recasens, Jordi Sintes, Meimei Shan, Nadia Polentarutti, Ramón García-Escudero, A Cooper Walland, John R Yeiser, Linda Cassis, Jorge Carrillo, Irene Puga, Cristina Cunha, Hélder Bastos, Fernando Rodrigues, João F Lacerda, António Morais, Rebeca Dieguez-Gonzalez, Peter S Heeger, Giovanni Salvatori, Agostinho Carvalho, Adolfo Garcia-Sastre, J Magarian Blander, Alberto Mantovani, Cecilia Garlanda, Andrea Cerutti
No abstract text is available yet for this article.
April 18, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28406074/editorial-old-drugs-%C3%A3-new-perspectives-new-compounds-%C3%A3-old-necessities-focusing-on-combating-microbial-resistance-part-ii
#5
EDITORIAL
Andre Luis Souza Dos Santos, Lucimar Ferreira Kneipp, Claudia Masini d'Avila-Levy, Catia Lacerda Sodre, Marta Helena Branquinha
No abstract text is available yet for this article.
2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28394223/gestational-outcomes-in-patients-with-neuropsychiatric-systemic-lupus-erythematosus
#6
G R de Jesus, B C Rodrigues, M I Lacerda, F C Dos Santos, N R de Jesus, E M Klumb, R A Levy
This study analyzed maternal and fetal outcomes of pregnancies of neuropsychiatric systemic lupus erythematosus patients followed in a reference unit. This retrospective cohort study included 26 pregnancies of patients seen between 2011 and 2015 included with history and/or active neuropsychiatric systemic lupus erythematosus among 135 pregnancies. Three patients had active neuropsychiatric systemic lupus erythematosus at conception, but only one remained with neurological activity during gestation, characteristically related to the inadvertent suspension of medications...
April 2017: Lupus
https://www.readbyqxmd.com/read/28391717/modulation-of-antibiotic-activity-by-the-hydroalcoholic-extract-from-leaves-of-caryocar-coriaceum-wittm
#7
Luís J de Lacerda Neto, A G B Ramos, M R Kerntopf, H D M Coutinho, L J Quintans-Junior, J R G S Almeida, J Ribeiro-Filho, I R A Menezes
The aim of this study was to identify the presence of tannins, phenols and flavonoids on the hydroalcoholic extract of Caryocar coriaceum leaves (HECCL) and to determine the antioxidant and antibacterial activity of this extract. The extract was tested alone (1024-1 μg/mL) or associated (MIC/8) with several antibiotics in order to identify any antibacterial activity against multiresistant bacterial strains (Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa). The existence of tannins, total phenols (901...
April 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28390393/regulatory-monocytes-in-helminth-infections-insights-from-the-modulation-during-human-hookworm-infection
#8
Lívia Silva Araújo Passos, Pedro Henrique Gazzinelli-Guimarães, Tiago Antônio de Oliveira Mendes, Ana Clara Gazzinelli Guimarães, Denise da Silveira Lemos, Natasha Delaqua Ricci, Ricardo Gonçalves, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno
BACKGROUND: While the macrophage polarization is well characterized in helminth infections, the natural heterogeneity of monocytes with multiple cell phenotypes might influence the outcome of neglected diseases, such hookworm infection. Here, we report the profile of monocytes in human hookworm infections as a model to study the regulatory subpopulation of monocytes in helminth infections. METHODS: Blood samples were collected from 19 Necator americanus-infected individuals and 13 healthy individuals...
April 8, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28389392/il-10-overexpression-predisposes-to-invasive-aspergillosis-by-suppressing-antifungal-immunity
#9
Cristina Cunha, Samuel M Gonçalves, Cláudio Duarte-Oliveira, Luís Leite, Katrien Lagrou, António Marques, Carmen B Lupiañez, Inês Mesquita, Joana Gaifem, Ana Margarida Barbosa, Carlos Pinho Vaz, Rosa Branca, Fernando Campilho, Fátima Freitas, Dário Ligeiro, Cornelia Lass-Flörl, Jürgen Löffler, Manuel Jurado, Margarida Saraiva, Oliver Kurzai, Fernando Rodrigues, António G Castro, Ricardo Silvestre, Juan Sainz, Johan A Maertens, Egídio Torrado, Ilse D Jacobsen, João F Lacerda, António Campos, Agostinho Carvalho
We show that the genetically-determined overexpression of IL-10 is a risk factor for invasive aspergillosis after stem-cell transplantation. Our results identify an IL-10-mediated mechanism that regulates the balance between anti- and proinflammatory antifungal immunity.
April 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28384192/plasmodium-vivax-gametocytes-in-the-bone-marrow-of-an-acute-malaria-patient-and-changes-in-the-erythroid-mirna-profile
#10
Barbara Baro, Katrien Deroost, Tainá Raiol, Marcelo Brito, Anne C G Almeida, Armando de Menezes-Neto, Erick F G Figueiredo, Aline Alencar, Rodrigo Leitão, Fernando Val, Wuelton Monteiro, Anna Oliveira, Maria Del Pilar Armengol, Carmen Fernández-Becerra, Marcus V Lacerda, Hernando A Del Portillo
No abstract text is available yet for this article.
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28380129/factors-associated-with-user-satisfaction-regarding-treatment-offered-in-brazilian-primary-health-care
#11
Ane Polline Lacerda Protasio, Luciano Bezerra Gomes, Liliane Dos Santos Machado, Ana Maria Gondim Valença
The Program for Access and Quality Improvement in Primary Care (PMAQ-AB) aimed to improve healthcare public service quality. The purpose of this study was to identify the main factors that influence user satisfaction in Brazilian primary health care services. This research was carried out using secondary data from the first cycle of the PMAQ-AB. A cluster analysis was carried out to find the dependent variable of user satisfaction; and logistic regression was applied in order to obtain the decision model. From the resulting regression model, two factors can be highlighted as regards influencing user satisfaction in Brazil: the user's perception that the team did not attempt to address their needs/problems within the health unit; and the user not feeling respected by the professionals in relation to cultural habits, customs, and religion or only sometimes feeling so...
March 30, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28375484/mutational-profile-of-tp53-in-esophageal-squamous-cell-carcinoma-associated-with-chagasic-megaesophagus
#12
C F Lacerda, A Cruvinel-Carloni, A T Torres de Oliveira, C Scapulatempo-Neto, R V M López, E Crema, S J Adad, M A M Rodrigues, M A C A Henry, D P Guimarães, R M Reis
Chaga's disease is an important communicable neglected disease that is gaining wider attention due to its increasing incidence worldwide. Achalasia due to chagasic megaesophagus (CM), a complication of this disease, is a known-yet, poorly understood-etiological factor for esophageal squamous cell carcinoma (ESCC) development. In this study, we aimed to perform the analysis of TP53 mutations in a series of Brazilian patients with ESCC that developed in the context CM (ESCC/CM), and to compare with the TP53 mutation profile of patients with benign CM and patients with nonchagasic ESCC...
April 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28371150/polyester-fibers-can-be-rendered-calcium-phosphate-binding-by-surface-functionalization-with-bisphosphonate-groups
#13
Alessandro Polini, Daniela Geta Petre, Michele Iafisco, Sonia de Lacerda Schickert, Anna Tampieri, Jeroen van den Beucken, Sander C G Leeuwenburgh
Fibers are often used as structural elements to improve the mechanical properties of materials such as brittle ceramic matrices by facilitating the dissipation of energy. However, this energy dissipation is mainly controlled by the interface between the two components, and a poorly designed fiber-matrix interface strongly reduces the efficacy of fiber reinforcement. Here, we present a versatile approach to control the affinity of biocompatible fibers to calcium-containing matrices in order to maximize the efficacy of reinforcement of calcium phosphates based bioceramics by means of polymeric fibers...
March 28, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28344091/determination-of-structural-and-thermodynamic-parameters-of-bovine-%C3%AE-trypsin-isoform-in-aqueous-organic-media
#14
Dayanne Pinho Rosa, Evaldo Vitor Pereira, Antonio Victor Baioco Vasconcelos, Maria Aparecida Cicilini, André Romero da Silva, Caroline Dutra Lacerda, Jamil Silvano de Oliveira, Marcelo Matos Santoro, Juliana Barbosa Coitinho, Alexandre Martins Costa Santos
The α-trypsin isoform is a globular protein that belongs to serine-protease family and has a polypeptide chain of 223 amino acid residues, six disulfide bridges and two domains with similar structures. The effects of aqueous-organic solvent (ethanol) in different concentration on the α-trypsin structure have been investigated by spectroscopic techniques and thermodynamic data analysis. The results from spectroscopic measurements, including far-UV Circular Dichroism, UV-vis absorption spectroscopy, intrinsic tryptophan fluorescence and dynamic light scattering (DLS) suggest the formation of partially folded states, instead of aggregate states, at high ethanol concentration (>60% v/v ethanol), with little loss of secondary structure, but with significant tertiary structure changes...
March 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28343961/protein-depletion-using-the-arabinose-promoter-in-xanthomonas-citri-subsp-citri
#15
Lilian A Lacerda, Lucia B Cavalca, Paula M M Martins, José S Govone, Maurício Bacci, Henrique Ferreira
Xanthomonas citri subsp. citri (X. citri) is a plant pathogen and the etiological agent of citrus canker, a severe disease that affects all the commercially important citrus varieties, and has worldwide distribution. Citrus canker cannot be healed, and the best method known to control the spread of X. citri in the orchards is the eradication of symptomatic and asymptomatic plants in the field. However, in the state of São Paulo, Brazil, the main orange producing area in the world, control is evolving to an integrated management system (IMS) in which growers have to use less susceptible plants, windshields to prevent bacterial spread out and sprays of cupric bactericidal formulations...
March 24, 2017: Plasmid
https://www.readbyqxmd.com/read/28330129/the-recombinant-pea-defensin-drr230a-is-active-against-impacting-soybean-and-cotton-pathogenic-fungi-from-the-genera-fusarium-colletotrichum-and-phakopsora
#16
Ariane Ferreira Lacerda, Rafael Perseghini Del Sarto, Marilia Santos Silva, Erico Augusto Rosas de Vasconcelos, Roberta Ramos Coelho, Vanessa Olinto Dos Santos, Claudia Vieira Godoy, Claudine Dinali Santos Seixas, Maria Cristina Mattar da Silva, Maria Fatima Grossi-de-Sa
Plant defensins are antifungal peptides produced by the innate immune system plants developed to circumvent fungal infection. The defensin Drr230a, originally isolated from pea, has been previously shown to be active against various entomopathogenic and phytopathogenic fungi. In the present study, the activity of a yeast-expressed recombinant Drr230a protein (rDrr230a) was tested against impacting soybean and cotton fungi. First, the gene was subcloned into the yeast expression vector pPICZαA and expressed in Pichia pastoris...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329027/prevalence-and-predictors-for-compensated-advanced-chronic-liver-disease-c-acld-in-patients-with-chronic-hepatitis-delta-virus-hdv-infection
#17
Ingrid Couto, Marilu Victoria, Valdiléa G Veloso, Lorena Rodrigues, Beatriz Grinsztejn, Marcus Lacerda, Flamir Victoria, Hugo Perazzo
OBJECTIVE: The study aimed to evaluate the prevalence and predictor factors for compensated advanced chronic liver disease (c-ACLD) in patients with hepatitis Delta virus (HDV) infection. METHODS: This cross-sectional study included consecutive HDV-infected patients defined by positive anti-HDV. Patients with hepatitis C coinfection, liver transplantation or presence of conditions that limit liver (LSM) or spleen stiffness measurement (SSM) were excluded. Blood tests, abdominal ultrasound, SSM and LSM by transient elastography (FibroScan®) were performed at the same day...
2017: PloS One
https://www.readbyqxmd.com/read/28328530/imaging-methods-for-bone-mass-evaluation-during-childhood-and-adolescence-an-update
#18
Isabela Leite Pezzuti, Adriana Maria Kakehasi, Maria Tereza Filgueiras, Juliana Albano de Guimarães, Isabela Alves Campos de Lacerda, Ivani Novato Silva
The objective of the work was to prepare an update on imaging methods for bone evaluation during childhood and adolescence. The text was based on original and review articles on imaging methods for clinical evaluation of bone mass in children and adolescents up to 20 years old. They were selected from BIREME and PUBMED by means of the following keywords: bone density; osteoporosis/diagnosis; densitometry; tomography; ultrasonography; magnetic resonance imaging; and radiogrammetry and published in Portuguese or English, in the last 10 years (2006-2016)...
March 22, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28327877/anxiety-stress-and-depression-in-family-members-of-patients-with-heart-failure
#19
Marianna Sobral Lacerda, Melissa Alves Cirelli, Alba Lúcia Bottura Leite de Barros, Juliana de Lima Lopes
OBJECTIVE: Identifying the level of anxiety, stress and depression symptoms in family members of patients with heart failure; identifying the relationship between these feelings with sociodemographic and clinical variables. METHOD: A cross-sectional study carried out with 100 family members. Depression, anxiety, and stress were evaluated by the Beck Depression and Anxiety Inventories and the Perceived Stress Scale - 10. The relationship between feelings and variables was performed through the t-test, Mann-Whitney or Kruskal-Wallis...
March 20, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28323068/vitamin-d-receptor-expression-and-hepcidin-levels-in-the-protection-or-severity-of-leprosy-a-systematic-review
#20
Ana Laura Grossi de Oliveira, Ana Thereza Chaves, Cristiane Alves Silva Menezes, Nathalia Sernizon Guimarães, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara, Manoel Otávio da Costa Rocha
Leprosy is a chronic infectious disease whose disequilibrium in the host's genetic, immunological and clinical mechanisms leads to distinct manifestations defining the type of immunological response. This review focuses its attention on the influence of the Vitamin D Receptor and hepcidin expressions that can suggest the protection or severity of leprosy.
March 16, 2017: Microbes and Infection
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