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https://www.readbyqxmd.com/read/28089578/dual-influences-of-early-life-maternal-deprivation-on-histone-deacetylase-activity-and-recognition-memory-in-rats
#1
Manoel Osório Albuquerque Filho, Betânia Souza de Freitas, Rebeca Carvalho Lacerda Garcia, Pedro Castilhos de Freitas Crivelaro, Nadja Schröder, Maria Noêmia Martins de Lima
Exposure to stress early in life may negatively impact nervous system functioning, including increasing the proneness to learning and memory impairments later in life. Maternal deprivation, a model of early-life stress, hinders memory in adult rats and lessens brain-derived neurotrophic factor (BDNF) levels in the hippocampus in a very heterogeneous way among individuals. The main goal of the present study was to investigate the possible epigenetic modulation underlying recognition memory impairment and reduced BDNF levels in the hippocampus of adult maternally deprived rats...
January 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28087323/severe-hemorrhagic-syndrome-after-lonomia-caterpillar-envenomation-in-the-western-brazilian-amazon-how-many-more-cases-are-there
#2
João Hugo A Santos, Sâmella S Oliveira, Eliane C Alves, Iran Mendonça-da-Silva, Jacqueline A G Sachett, Antonio Tavares, Luiz Carlos Ferreira, Hui Wen Fan, Marcus V G Lacerda, Wuelton M Monteiro
Contact with Lonomia caterpillars can cause a hemorrhagic syndrome. In Brazil, Lonomia obliqua and Lonomia achelous are known to cause this venom-induced disease. In the Brazilian Amazon, descriptions of this kind of envenomation are scarce. Herein, we report a severe hemorrhagic syndrome caused by Lonomia envenomation in the Amazonas state, Western Brazilian Amazon. The patient showed signs of hemorrhage lasting 8 days and required Lonomia antivenom administration, which resulted in resolution of hemorrhagic syndrome...
January 10, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28057425/oral-phaeohyphomycosis-in-a-patient-with-squamocellular-carcinoma-of-the-lip-second-case-report
#3
Suanni Lemos de Andrade, André Ferraz Goiana Leal, Armando Marsden Lacerda Filho, Danielle Patrícia Cerqueira Macêdo, Maria do Carmo Carvalho de Abreu E Lima, Rejane Pereira Neves
This communication reports the second known case of oral phaeohyphomycosis in a patient with squamocellular carcinoma of the lip. The patient, an 82-year-old black woman, a former smoker (for more than 30 years), suffering from an ulcerous vegetative lesion in the middle third of the lower lip for approximately 12 months. The result of the histopathological analysis indicated carcinoma, with well-differentiated keratinized squamous cells and the presence of septate mycelial filaments. In the direct mycological examination, thick and dematiaceous septate mycelial filaments were observed...
December 22, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28054334/comprehensive-candidate-gene-analysis-for-symptomatic-or-asymptomatic-outcomes-of-leishmania-infantum-infection-in-brazil
#4
Jason L Weirather, Priya Duggal, Eliana L Nascimento, Gloria R Monteiro, Daniella R Martins, Henio G Lacerda, Michaela Fakiola, Jenefer M Blackwell, Selma M B Jeronimo, Mary E Wilson
Genetic risk factors contribute to asymptomatic versus symptomatic visceral leishmaniasis (VL) outcomes following infection with Leishmania infantum. We therefore carried out a family-based (n = 918 post-quality control fully genotyped and phenotyped individuals) candidate gene study for symptomatic VL or asymptomatic delayed-type hypersensitivity (DTH) skin test phenotypes in highly endemic neighborhoods of northeast Brazil. A total of 248 SNPs were genotyped in 42 genes selected as candidates on the basis of prior genetic, immunological, and transcriptional profiling studies...
January 4, 2017: Annals of Human Genetics
https://www.readbyqxmd.com/read/28052760/evaluation-of-the-importance-of-fever-with-respect-to-dengue-prognosis-according-to-the-2009-who-classification-a-retrospective-study
#5
Caroline Tukasan, Nathália Barbosa Furlan, Cássia Fernanda Estofolete, Maurício Lacerda Nogueira, Natal Santos da Silva
BACKGROUND: The 2009 revised World Health Organization (WHO) guidelines for dengue describe fever as the core symptom. Accordingly, the diagnosis of non-febrile patients is complicated. The aim of this study was to evaluate the importance of fever in patients with dengue according to the 2009 revised WHO classification. METHODS: In this study, we assessed 30,670 dengue cases using enzyme-linked immunosorbent assay, detection of the non-structural protein 1, or polymerase chain reaction for diagnostic confirmation...
January 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28040324/metabolomics-and-lipidomics-analyses-by-1-h-nuclear-magnetic-resonance-of-schizophrenia-patient-serum-reveal-potential-peripheral-biomarkers-for-diagnosis
#6
Ljubica Tasic, João G M Pontes, Michelle S Carvalho, Guilherme Cruz, Carolines Dal Mas, Sumit Sethi, Mariana Pedrini, Lucas B Rizzo, Maiara Zeni-Graiff, Elson Asevedo, Acioly L T Lacerda, Rodrigo A Bressan, Ronei Jesus Poppi, Elisa Brietzke, Mirian A F Hayashi
Using (1)H NMR-based metabolomics in association to chemometrics analysis, we analyzed here the metabolic differences between schizophrenia patients (SCZ) compared to healthy controls (HCs). HCs and SCZ patients underwent clinical interview using the Structured Clinical Interview for DSM Disorders (SCID). SCZ patients were further assessed by Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale, Global Assessment of Functioning Scale (GAF), and Clinical Global Impressions Scale (CGI). Using the principal component analysis (PCA) and supervised partial least-squares discriminate analysis (PLS-DA) in obtained NMR data, a clear group separation between HCs and SCZ patients was achieved...
December 28, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/28029189/morphological-and-immunohistochemical-analysis-of-the-biocompatibility-of-resin-modified-cements
#7
Janaina Almeida Mesquita, Rogério Lacerda-Santos, Gustavo Pina Godoy, Cassiano Franscisco Weege Nonaka, Pollianna Muniz Alves
The aim of this double-blind randomized study was to evaluate the biocompatibility of resin-modified glass ionomer cements (RMGIC) by means of morphological and immunohistochemical analyses. RMGICs were selected and divided into four groups: Group CK (Crosslink Orthodontic Band Cement); Group RS (Resilience Light Cure Band Cement) Group RMO (RMO Band Cement), Group TP (Transbond Plus Light Cure Band), and Group C (Control-polyethylene). The materials were implanted in rat subcutaneous tissues, randomly selected for this study...
December 28, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28027593/behavior-of-sheep-fed-babassu-cake-orbygnia-speciosa-as-a-substitution-for-elephant-grass-silage
#8
Ernestina Ribeiro Dos Santos Neta, Kaliandra Souza Alves, Rafael Mezzomo, Daiany Íris Gomes, Luis Rennan Sampaio Oliveira, Francisco Fernando Ramos de Carvalho, Janaina Barros Luz, Natália Gomes Lacerda, Venucia de Diniella Dos Santos Bourdon
This study aimed to evaluate the behavior of sheep fed babassu cake as a substitution for elephant grass silage. The experiment was conducted at the Federal Rural University of Amazonia (Universidade Federal Rural da Amazônia - UFRA), Brazil, using 45 sheep housed in individual stalls, with unlimited access to feed and distributed in a completely randomized design with five treatments (0, 12.5, 25, 37.5 and 50% inclusion of babassu cake) and nine replications. All of the treatments contained a roughage-to-concentrate ratio of 40:60...
December 27, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28025688/mercury-concentrations-in-tuna-thunnus-albacares-and-thunnus-obesus-from-the-brazilian-equatorial-atlantic-ocean
#9
L D Lacerda, F Goyanna, M F Bezerra, G B Silva
Average total Hg concentrations measured in muscle of two species of tuna (Thunnus obesus and T. albacares) captured in the Brazilian Equatorial Atlantic Ocean varied from 95 to 1748 ng.g(-1) wet weight in T. obesus and 48 to 500 ng.g(-1) wet weight in T. albacares. Higher concentrations in T. obesus are probably related to foraging on deep water carnivorous fish. Smaller individuals of both species showed the lowest concentrations, but a significant positive relationship between fish weight and length and Hg concentrations was found for T...
December 26, 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28003150/concomitant-helminth-infection-downmodulates-the-vaccinia-virus-specific-immune-response-and-potentiates-virus-associated-pathology
#10
Pedro Henrique Gazzinelli-Guimarães, Lorena Falabella Daher de Freitas, Ana Clara Gazzinelli-Guimarães, Fabiana Coelho, Fernando Sérgio Barbosa, Denise Nogueira, Chiara Amorim, Lucas de Carvalho Dhom-Lemos, Luciana Maria Oliveira, Alexandre Barcelos da Silveira, Flávio Guimarães da Fonseca, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara
The aim of this work was to elucidate the immunopathological mechanisms of how helminths may influence the course of a viral infection, using a murine model. Severe virulence, a relevant increase in the virus titres in the lung and a higher mortality rate were observed in Ascaris and Vaccinia virus (VACV) co-infected mice, compared with VACV mono-infected mice. Immunopathological analysis suggested that the ablation of CD8(+) T cells, the marked reduction of circulating CD4(+) T cells producing IFN-γ, and the robust pulmonary inflammation were associated with the increase of morbidity/mortality in co-infection and subsequently with the negative impact of concomitant pulmonary ascariasis and respiratory VACV infection for the host...
December 18, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27994205/polymorphism-in-ficolin-1-fcn1-gene-is-associated-with-an-earlier-onset-of-type-1-diabetes-mellitus-in-children-and-adolescents-from-northeast-brazil
#11
Zilma Pereira Dos Anjosa, Manuella Maria Silva Santos, Natassia Javorski Rodrigues, Glaucia Alyne Nunes De Lacerda, Jaqueline Araujo, Jaqueline De Azevêdo Silva, Nathália De Alencar Cunha Tavares, Rafael Lima Guimarães, Sergio Crovella, Lucas André Cavalcanti Brandão
No abstract text is available yet for this article.
December 2016: Journal of Genetics
https://www.readbyqxmd.com/read/27992039/-evaluation-of-the-mobile-emergency-care-service-in-santa-catarina-state-brazil
#12
Angela Maria Blatt Ortiga, Josimari Telino de Lacerda, Sonia Natal, Maria Cristina Marino Calvo
This case study evaluated the Mobile Emergency Care Service (SAMU) in Santa Catarina State, Brazil, in 2013/2014. The theoretical log frame and evaluation matrix were validated by expert consensus workshops. Two dimensions were proposed: emergency care management and emergency care, analyzed with 22 indicators. Data collection used interviews, direct observation in the eight regional SAMU dispatches, and a questionnaire sent to the coordinators of the municipal SAMU. The analysis and value judgment according to separate dimensions, sub-dimensions, and indicators allowed identifying strengths and weaknesses amenable to intervention...
December 15, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27991993/caregivers-resilience-is-independent-from-the-clinical-symptoms-of-dementia
#13
Rachel Dias, José Pedro Simões-Neto, Raquel Luiza Santos, Maria Fernanda Barroso de Sousa, Maria Alice Tourinho Baptista, Isabel Barbeito Lacerda, Nathalia Ramos Santos Kimura, Marcia Cristina Nascimento Dourado
Resilience is the capacity for successful adaptation when faced with the stress of adversity. We aimed to investigate the relationship between caregivers' resilience and the sociodemographic and clinical factors of people with dementia. Cross-sectional assessment of 58 people with dementia and their caregiver dyads showed that most caregivers were female adult children. The caregivers reported moderate to higher levels of resilience, lower levels of anxiety and depressive symptoms and moderate levels of burden...
December 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27988484/fixed-dose-artesunate-amodiaquine-combination-vs-chloroquine-for-treatment-of-uncomplicated-blood-stage-p-vivax-infection-in-the-brazilian-amazon-an-open-label-randomized-controlled-trial
#14
Andre M Siqueira, Aline C Alencar, Gisely C Melo, Belisa L Magalhaes, Kim Machado, Aristóteles C Alencar Filho, Andrea Kuehn, Marly M Marques, Monica Costa Manso, Ingrid Felger, José L F Vieira, Valerie Lameyre, Claudio T Daniel-Ribeiro, Marcus V G Lacerda
BACKGROUND: Despite increasing evidence of the development of Plasmodium vivax chloroquine (CQ) resistance, there have been no trials comparing its efficacy with that of artemisinin-based combination therapies (ACTs) in Latin America. METHODS: This randomized controlled trial compared the antischizontocidal efficacy and safety of a 3-day supervised treatment of the fixed-dose combination artesunate-amodiaquine Winthrop(®) (ASAQ) versus CQ for treatment of uncomplicated P...
January 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27986827/potential-of-semiarid-soil-from-caatinga-biome-as-a-novel-source-for-mining-lignocellulose-degrading-enzymes
#15
Gileno Lacerda Júnior, Melline Noronha, Sanderson Tarciso de Sousa, Lucélia Cabral, Daniela Domingos, Mírian Sáber, Itamar de Melo, Valéria Oliveira
The litterfall is the major organic material deposited in soil of Brazilian Caatinga biome, thus providing the ideal conditions for plant biomass-degrading microorganisms to thrive. Herein, the phylogenetic composition and lignocellulose degrading capacity have been explored for the first time from a fosmid library dataset of Caatinga soil by sequence-based screening. A complex bacterial community dominated by Proteobacteria and Actinobacteria was unraveled. SEED subsystems-based annotations revealed a broad range of genes assigned to carbohydrate and aromatic compounds metabolism, indicating microbial ability to utilize plant-derived material...
December 15, 2016: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/27986616/thermogenesis-fatty-acid-synthesis-with-oxidation-and-inflammation-in-the-brown-adipose-tissue-of-ob-ob-mice
#16
Fabiane Ferreira Martins, Thereza Cristina Lonzetti Bargut, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Brown adipose tissue (BAT) is specialized in heat production, but its metabolism in ob/ob mice is still a matter of debate. We aimed to verify ob/ob mice BAT using C57Bl/6 male mice (as the wild-type, WT) and leptin-deficient ob/ob mice (on the C57Bl/6 background strain), at three months of age (n=10/group). At euthanasia, animals had their interscapular BAT weighed, and prepared for analysis (Western blot, and RT-qPCR). In comparison with the WT group, the ob/ob group showed reduced thermogenic signaling markers (gene expression of beta 3-adrenergic receptor, beta3-AR; PPARgamma coactivator 1 alpha, PGC1alpha, and uncoupling protein 1, UCP1)...
December 13, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27984144/lectin-from-seeds-of-a-brazilian-lima-bean-variety-phaseolus-lunatus-l-var-cascavel-presents-antioxidant-antitumour-and-gastroprotective-activities
#17
Rodrigo Rodrigues E Lacerda, Edilza Silva do Nascimento, José Thalles Jocelino Gomes de Lacerda, Luciano da Silva Pinto, Caroline Rizzi, Mirna Marques Bezerra, Isabela Ribeiro Pinto, Samuel Mateus Pereira Filho, Vicente de Paulo Texeira Pinto, Gerardo Cristino Filho, Carlos Alberto de Almeida Gadelha, Tatiane Santi Gadelha
Lectins are proteins able to interact specifically and reversibly with carbohydrates. They are present in all living beings, particularly in legume seeds, which have many biological functions. The aim of this study was to isolate, characterize and verify antioxidant, anti-hemolytic, antitumor and gastroprotective activities in a lectin present in seeds of Phaseolus lunatus L. var. cascavel (PLUN). The isolation of lectin was performed by size exclusion chromatography on Sephadex G-100, which was isolated from a protein capable of agglutinating only human erythrocytes type A, being this the only inhibited haemagglutination n-acetyl-d-galactosamine...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27982334/modified-technique-for-preparation-of-venous-circulation-resin-casts-in-the-cirrhotic-liver
#18
José Olímpio Maia DE Vasconcelos, Laécio Leitão Batista, Guilherme Benjamin Brandão Pitta, Cláudio Moura Lacerda
This study describes two major adaptations for the preparation of resin casts in human cirrhotic liver, harvested at the time of transplantation. The first is the way of fixing the catheter in the ostia of the hepatic and portal veins through a cerclage, so as to prevent displacement of the catheter and / or leakage of the resin during its injection. The second is the extension of corrosion time in the NaOH solution, averaging 6.8 days, with daily replacement the solution until complete removal of parenchymal tissue...
September 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27982326/analysis-of-the-revised-trauma-score-rts-in-200-victims-of-different-trauma-mechanisms
#19
Bruno Durante Alvarez, Danilo Mardegam Razente, Daniel Augusto Mauad Lacerda, Nicole Silveira Lother, Luiz Carlos VON-Bahten, Carla Martinez Menini Stahlschmidt
Objective: to analyze the epidemiological profile and mortality associated with the Revised Trauma Score (RTS) in trauma victims treated at a university hospital. Methods: we conducted a descriptive, cross-sectional study of trauma protocols (prospectively collected) from December 2013 to February 2014, including trauma victims admitted in the emergency room of the Cajuru University Hospital. We set up three groups: (G1) penetrating trauma to the abdomen and chest, (G2) blunt trauma to the abdomen and chest, and (G3) traumatic brain injury...
September 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27982191/effects-of-image-compression-on-linear-measurements-of-digital-panoramic-radiographs
#20
Leonardo Francisco Provedel, Bruna Natália Alves da Silva Pimentel, Tarcísio Martins de Jesus, Ana Paula Souza Lacerda, Izabel Regina Fischer Rubira-Bullen, Viviane Almeida Sarmento
This study aimed to evaluate the accuracy of panoramic radiographs obtained by digital system based on charge coupled device (CCD) and a phosphor storage plate (PSP) system with two different file formats, JPEG irreversible type and BMP. Linear measurements of artificial bony defects were made in dry mandibles with a digital caliper. Measures of digital panoramic radiographs were taken in ImageJ(r) software. Each measurement was performed twice by an experienced examiner. The intra-rater agreement was considered very strong (Pearson's correlation coefficient of 0...
October 2016: Brazilian Dental Journal
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