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https://www.readbyqxmd.com/read/28935426/cis-rucl-bzcn-bipy-dppe-pf6-induces-anti-angiogenesis-and-apoptosis-by-a-mechanism-of-caspase-dependent-involving-dna-damage-parp-activation-and-tp53-induction-in-ehrlich-tumor-cells
#1
Lorena Félix Magalhães, Francyelli Mello-Andrade, Wanessa Carvalho Pires, Hugo Delleon Silva, Larissa Matuda Macedo, Carlos Henrique de Castro, Cristiene Costa Carneiro, Clever Gomes Cardoso, Paulo Roberto de Melo Reis, Laís Camargo de Oliveira, Renata Rodrigues Caetano, Alzir A Batista, Elisângela de Paula Silveira-Lacerda
Antimetastatic activities, low toxicity to normal cells and high selectivity for tumor cells make of the ruthenium complexes promising candidates in the search for develop new chemotherapeutic agents for the treatment of cancer. This study aimed to determine the cytotoxic, genotoxic and to elucidate the signaling pathway involved in the death cell process induced by cis-[RuCl(BzCN) (bipy) (dppb)]PF6(1) and cis-[RuCl(BzCN) (bipy) (dppe)]PF6(2) in Ehrlich ascites carcinoma (EAC) in vitro. Moreover, we report for the first time the anti-angiogenic potential on chick embryo chorioallantoic membrane (CAM) model...
September 18, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28927874/zika-detection-comparison-of-methodologies
#2
Tatiana Elias Colombo, Ana Carolina Bernardes Terzian, João Pessoa Araújo Júnior, Ricardo Parreira, Eliana Márcia Sotello Cabrera, Izalco Nuremberg Penha Dos Santos, Andréia Francesli Negri Reis, Fabiana Rodrigues Costa, Lilian Elisa Arão Antônio Cruz, Patrícia Lopes Rombola, Maurício Lacerda Nogueira
Many countries in the Americas have detected local transmission of multiple arboviruses that cause febrile illnesses. Therefore, laboratory testing has become an important tool for confirming the etiology of these diseases. The present study aimed to compare the sensitivity and specificity of three different Zika virus detection assays. One hundred serum samples from patients presenting with acute febrile symptoms were tested using a previously reported TaqMan(®) RT-qPCR assay. We used a SYBR(®) Green RT-qPCR and a conventional PCR methodologies to compare the results...
August 30, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28927849/metabolome-wide-association-study-of-peripheral-parasitemia-in-plasmodium-vivax-malaria
#3
Luiz Gustavo Gardinassi, Regina Joice Cordy, Marcus V G Lacerda, Jorge L Salinas, Wuelton M Monteiro, Gisely C Melo, André M Siqueira, Fernando F Val, ViLinh Tran, Dean P Jones, Mary R Galinski, Shuzhao Li
BACKGROUND: Plasmodium vivax is one of the leading causes of malaria worldwide. Infections with this parasite cause diverse clinical manifestations, and recent studies revealed that infections with P. vivax can result in severe and fatal disease. Despite these facts, biological traits of the host response and parasite metabolism during P. vivax malaria are still largely underexplored. Parasitemia is clearly related to progression and severity of malaria caused by P. falciparum, however the effects of parasitemia during infections with P...
September 6, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28927386/patients-perception-regarding-the-influence-of-individual-and-social-vulnerabilities-on-the-adherence-to-tuberculosis-treatment-a-qualitative-study
#4
Rosiane Davina da Silva, Fernanda Darliane Tavares de Luna, Aguinaldo José de Araújo, Edwirde Luiz Silva Camêlo, Maria Rita Bertolozzi, Paula Hino, Sheylla Nadjane Batista Lacerda, Sayonara Maria Lia Fook, Tânia Maria Ribeiro Monteiro de Figueiredo
BACKGROUND: Tuberculosis remains an important disease which mainly affects the majority of vulnerable individuals in society, who are subjected to poor living conditions and difficulties to access the services of public health. Under these circumstances, the present study aims to understand patients' perception in relation to the influence of individual and social vulnerabilities on the adherence to tuberculosis treatment. METHODS: A qualitative descriptive cross sectional study was conducted in one large municipality at the state of Paraíba, Northeast of Brazil...
September 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28918127/clinical-laboratory-and-virological-data-from-suspected-zikv-patients-in-an-endemic-arbovirus-area
#5
Tatiana Elias Colombo, Cássia Fernanda Estofolete, Andréia Francesli Negri Reis, Natal Santos da Silva, Morgana Lima Aguiar, Eliana Márcia Sotello Cabrera, Izalco Nuremberg Penha Dos Santos, Fabiana Rodrigues Costa, Lilian Elisa Arão Antônio Cruz, Patrícia Lopes Rombola, Ana Carolina Bernardes Terzian, Maurício Lacerda Nogueira
BACKGROUND: The emergence of Zika virus (ZIKV) presents new challenges to both clinicians and public health authorities. Overlapping clinical features between the diseases caused by ZIKV, dengue (DENV) and chikungunya (CHIKV) and the lack of validated serological assays for ZIKV make accurate diagnosis difficult. Brazilian authorities largely rely on clinical and epidemiological data for the epidemiological and clinical classifications of most ZIKV cases. OBJECTIVE: To report the laboratory and clinical profiles of patients diagnosed with Zika fever based only on clinical and epidemiological data...
September 9, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28917795/portable-near-infrared-spectroscopy-applied-to-quality-control-of-brazilian-coffee
#6
Radigya M Correia, Flavia Tosato, Eloilson Domingos, Rayza R T Rodrigues, Luiz Felipe M Aquino, Paulo R Filgueiras, Valdemar Lacerda, Wanderson Romão
The use of portable micro-spectrometers such as a micro near infrared region (microNIR) spectrometer is a promising technique for solving analytical problems in several areas of science. This work evaluated the potential of microNIR in quality control of Arabica coffee. Arabica coffee has a high commercial value product, motivating the development of analytical methods with high sensitivity and accuracy for detection of its adulteration. Herein, microNIR was successfully used to determine the quality of Arabica coffee by identification and quantification of adulterations such as Robusta coffee (in different roasting levels), as well as corn, peels, and sticks...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28913723/therapeutic-implications-of-the-molecular-and-immune-landscape-of-triple-negative-breast-cancer
#7
REVIEW
Ana C Gregório, Manuela Lacerda, Paulo Figueiredo, Sérgio Simões, Sérgio Dias, João Nuno Moreira
Treatment and management of breast cancer imposes a heavy burden on public health care, and incidence rates continue to increase. Breast cancer is the most common female neoplasia and primary cause of death among women worldwide. The recognition of breast cancer as a complex and heterogeneous disease, comprising different molecular entities, was a landmark in our understanding of this malignancy. Valuing the impact of the molecular characteristics on tumor behavior enabled a better assessment of a patient's prognosis and increased the predictive power to therapeutic response and clinical outcome...
September 14, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28894335/primary-osteosarcoma-of-the-cranial-vault
#8
Gabriel Lacerda Fernandes, Marcelo Ricardo Canuto Natal, Célio Lúcio Palha da Cruz, Rafael Lemos Nascif, Niedja Santos Gonçalves Tsuno, Marco Yukio Tsuno
Only 5-10% of osteosarcomas arise from the craniofacial bones. We report the case of a 14-year-old female patient who presented with headache and a mass that had been growing in the left frontoparietal region for six months. We describe the findings on conventional radiography, computed tomography, and magnetic resonance imaging.
July 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28892806/a-novel-missense-gla-mutation-p-g35v-detected-in-hemodialysis-screening-leads-to-severe-systemic-manifestations-of-fabry-disease-in-men-and-women
#9
Valeria Soares Pigozzi Veloso, Thiago Lacerda Ataides, Maria Eugênia Fernandes Canziani, Mariana Pigozzi Veloso, Nilzio Antônio da Silva, Daniela Veit Barreto, Edna Regina Silva Pereira, Luiz Antonio Ribeiro de Moura, Fellype Carvalho Barreto
BACKGROUND/AIMS: Fabry disease (FD), an X-linked lysosomal storage disorder, leads to accumulation of globotriaosylceramide. Screening in dialysis patients may identify genetic variants of unknown clinical significance. We aimed to characterize the pathogenicity of a novel GLA gene mutation identified during hemodialysis screening and the histologic findings of early Fabry nephropathy. METHODS: One out of 108 male hemodialysis patients screened for FD presented low α-galactosidase A activity...
September 12, 2017: Nephron
https://www.readbyqxmd.com/read/28892517/naturally-acquired-antibody-responses-to-more-than-300-plasmodium-vivax-proteins-in-three-geographic-regions
#10
Rhea J Longley, Michael T White, Eizo Takashima, Masayuki Morita, Bernard N Kanoi, Connie S N Li Wai Suen, Inoni Betuela, Andrea Kuehn, Piyarat Sripoorote, Camila T Franca, Peter Siba, Leanne J Robinson, Marcus Lacerda, Jetsumon Sattabongkot, Takafumi Tsuboi, Ivo Mueller
Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2-3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input...
September 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28889187/measurements-between-the-hepatic-veins-and-portal-venous-system-in-human-cirrhotic-liver-a-cast-study
#11
José-Olímpio M Vasconcelos-Filho, Adamastor H Pereira, Guilherme B B Pitta, Laécio Leitão-Batista, Aldemar A Castro, Alberto Ribeiro Souza-Leão, Cláudio M Lacerda
PURPOSE: To measure the distance between the right and middle hepatic veins and portal vein branches, in human cirrhotic liver casts. Was this measure actually smaller in the cirrhotic liver than in normal one? MATERIALS AND METHODS: This study was authorized by an area Research Ethics Committee, and each study subject or legal representative granted signed informed consent. Acrylic corrosion casts of 21 resected cirrhotic livers were generated. Diameters of hepatic veins and portal branches and pertinent intervening distances were measured...
September 9, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28888743/htlv-1-infected-thymic-epithelial-cells-convey-the-virus-to-cd4-t-lymphocytes
#12
Luciana Rodrigues Carvalho Barros, Leandra Linhares-Lacerda, Klaysa Moreira-Ramos, Marcelo Ribeiro-Alves, Maria Cristina Machado Motta, Dumith Chequer Bou-Habib, Wilson Savino
The human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of adult T cell leukemia/lymphoma (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4(+)T cells are the main target of HTLV-1, but other cell types are known to be infected, including immature lymphocytes. Developing T cells undergo differentiation in the thymus, through migration and interaction with the thymic microenvironment, in particular with thymic epithelial cells (TEC) the major component of this three dimensional meshwork of non-lymphoid cells...
August 14, 2017: Immunobiology
https://www.readbyqxmd.com/read/28887661/widening-the-spectrum-of-deletions-and-molecular-mechanisms-underlying-alpha-thalassemia
#13
José Ferrão, Marisa Silva, Lúcia Gonçalves, Susana Gomes, Pedro Loureiro, Andreia Coelho, Armandina Miranda, Filomena Seuanes, Ana Batalha Reis, Francisca Pina, Raquel Maia, Paula Kjöllerström, Estela Monteiro, João F Lacerda, João Lavinha, João Gonçalves, Paula Faustino
Inherited deletions of α-globin genes and/or their upstream regulatory elements (MCSs) give rise to α-thalassemia, an autosomal recessive microcytic hypochromic anemia. In this study, multiplex ligation-dependent probe amplification performed with commercial and synthetic engineered probes, Gap-PCR, and DNA sequencing were used to characterize lesions in the sub-telomeric region of the short arm of chromosome 16, possibly explaining the α-thalassemia/HbH disease phenotype in ten patients. We have found six different deletions, in heterozygosity, ranging from approximately 3...
September 8, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28876427/geographical-distribution-of-medical-graduates-from-a-public-university
#14
Oscarina da Silva Ezequiel, Giancarlo Lucchetti, Alessandra Lamas Granero Lucchetti, Maria Helena Senger, Lucas Braga, Rafael Lacerda, Marlon Filippo, Fernando Colugnati, Danette McKinley, Eliana Amaral
Objective: To evaluate the geographic distribution and career trajectory of medical graduates and the factors associated with their choice of practice location. Method: A cross-sectional study involving graduates from December 2001 to December 2010 was conducted. A self-administered questionnaire collected demographics and geographic information (place of birth, place of residence at the time of medical school admission, place of residency training and practice location), and reason for choosing the current location...
June 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28876382/detection-purification-and-characterization-of-a-lectin-from-freshwater-green-algae-spirogyra-spp
#15
Antônia S DE Oliveira, Cláudia F Lóssio, Anne J Rangel, Maria G Q Martins, Fernando E P DO Nascimento, Maria L L DE Andrade, Benildo S Cavada, Sírleis R Lacerda, Kyria S DO Nascimento
Freshwater algae are rich sources of structurally biologically active metabolites, such as fatty acids, steroids, carotenoids and polysaccharides. Among these metabolites, lectins stand out. Lectins are proteins or glycoproteins of non-immune origin which bind to carbohydrates or glycoconjugates, without changing ligand structure. Many studies have reported on the use of Spirogyra spp. as effective bioindicators of heavy metals; however, reports on Spirogyra molecular bioprospecting are quite limited. Therefore, this study aimed to detect, isolate, purify and characterize a lectin present in the freshwater green algae Spirogyra...
August 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28874800/mechanism-of-splenic-cell-death-and-host-mortality-in-a-plasmodium-yoelii-malaria-model
#16
Norinne Lacerda-Queiroz, Nicolas Riteau, Richard T Eastman, Kevin W Bock, Marlene S Orandle, Ian N Moore, Alan Sher, Carole A Long, Dragana Jankovic, Xin-Zhuan Su
Malaria is a fatal disease that displays a spectrum of symptoms and severity, which are determined by complex host-parasite interactions. It has been difficult to study the effects of parasite strains on disease severity in human infections, but the mechanisms leading to specific disease phenotypes can be investigated using strains of rodent malaria parasites that cause different disease symptoms in inbred mice. Using a unique mouse malaria model, here we investigated the mechanisms of splenic cell death and their relationship to control of parasitemia and host mortality...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28873739/effect-of-symbiotic-interaction-between-a-fructooligosaccharide-and-probiotic-on-the-kinetic-fermentation-and-chemical-profile-of-maize-blended-rice-beverages
#17
Ana Luiza Freire, Cintia Lacerda Ramos, Rosane Freitas Schwan
There is an important demand for the development of new non-dairy probiotic beverages in the functional food market. This work aimed to develop new fermented beverages from maize and rice. Lactobacillus plantarum CCMA 0743, Torulaspora delbrueckii CCMA 0235, and the commercial probiotic Lactobacillus acidophilus LACA 4, were used as a mixed starter culture. Two prebiotic concentrations, 20 and 50g/L fructooligosaccharide (FOS) were tested. The growth of L. acidophilus LACA 4 was favored by 50g/L FOS and after refrigerated storage at 4°C for 28days, its population remained above 10(7)CFU/mL...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28855720/side-effects-of-pesticides-on-the-generalist-endoparasitoid-palmistichus-elaeisis-hymenoptera-eulophidae
#18
Ricardo Alcántara-de la Cruz, José Cola Zanuncio, Mabio Chrisley Lacerda, Carlos Frederico Wilcken, Flávio Lemes Fernandes, Wagner de Souza Tavares, Marcus Alvarenga Soares, Carlos Sigueyuki Sediyama
New plant protection strategies focus on minimizing chemical pesticide use and increasing their compatibility with biological control agents. The objective was to evaluate the side-effects of glyphosate, diflubenzuron, malathion, tebuconazole and triflumuron (at 720, 45, 400, 150 and 20 g ai ha(-1), respectively), pesticides authorized for soybean crops in Brazil, on the parasitoid Palmistichus elaeisis (Hymenoptera: Eulophidae) reared on Anticarsia gemmatalis (Lepidoptera: Noctuidae). The emergence and female numbers produced per P...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28847026/relationship-between-anxiety-and-interleukin-10-in-female-soccer-players-with-and-without-premenstrual-syndrome-pms
#19
Roberta Foster, Mauro Vaisberg, Maíta Poli de Araújo, Marcia Aparecida Martins, Tiago Capel, Andre Luis Lacerda Bachi, Zsuzsanna Ilona Katalin de Jármy-Di Bella
Objective To investigate the level of anxiety and its relationship with interleukin (IL)-10 (anti inflammatory cytokine that modulates mood swings) in a group of female soccer players. Methods Fifty-two eumenorrheic soccer players were evaluated (age 19.8 ± 4.7 years). The presence of premenstrual syndrome (PMS) and phases of the menstrual cycle were determined by a daily symptom report (DSR) kept for 3 consecutive months. The concentration of cytokine IL-10 was determined from urine samples collected at four moments: at the follicular and luteal phases of the menstrual cycle, and before (pre) and after (post) the simulated game, and it was quantified by flow cytometry (Luminex xMAP - EMD Millipore, Billerica, MA, USA)...
August 28, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28846929/glyphosate-based-herbicides-toxicity-on-life-history-parameters-of-zoophytophagous-podisus-nigrispinus-heteroptera-pentatomidae
#20
José C Zanuncio, Mabio C Lacerda, Ricardo Alcántara-de la Cruz, Bruno P Brügger, Alexandre I A Pereira, Carlos F Wilcken, José E Serrão, Carlos S Sediyama
The increase of agricultural areas with glyphosate-resistant (GR) crops, and use of this herbicide in Brazil, makes necessary to assess its impacts on non-target organisms. The objective was to evaluate the development, reproduction and life table parameters of Podisus nigrispinus (Heteroptera: Pentatomidae) reared on GR-soybean plants treated with glyphosate formulations (Zapp-Qi, Roundup-Transorb-R and Roundup-Original) at the recommended field dose (720g acid equivalent ha(-1)). Glyphosate formulations had no affect on nymph and adult weight of this predator...
August 25, 2017: Ecotoxicology and Environmental Safety
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