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https://www.readbyqxmd.com/read/29141627/in-vitro-properties-of-concentrated-canine-platelets-stored-in-two-additive-solutions-a-comparative-study
#1
N Hlavac, C S Lasta, M L Dalmolin, L A Lacerda, D de Korte, N A Marcondes, S R Terra, F B Fernandes, F H D González
BACKGROUND: Platelet transfusion therapy poses many challenges in veterinary clinical practice. Lack of readily available blood donors, short shelf-life, and inability to administer a sufficient number of platelets to meet a dog's transfusion need are the major difficulties encountered. Platelet additive solutions are already in use at American and European human blood banks, showing to be a realistic alternative. This study compares the in vitro platelet function in plasma, Composol, or SSP+ during storage for 13 days...
November 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29140260/vaccinia-virus-natural-infections-in-brazil-the-good-the-bad-and-the-ugly
#2
REVIEW
Jaqueline Silva de Oliveira, Poliana de Oliveira Figueiredo, Galileu Barbosa Costa, Felipe Lopes de Assis, Betânia Paiva Drumond, Flávio Guimarães da Fonseca, Maurício Lacerda Nogueira, Erna Geessien Kroon, Giliane de Souza Trindade
The orthopoxviruses (OPV) comprise several emerging viruses with great importance to human and veterinary medicine, including vaccinia virus (VACV), which causes outbreaks of bovine vaccinia (BV) in South America. Historically, VACV is the most comprehensively studied virus, however, its origin and natural hosts remain unknown. VACV was the primary component of the smallpox vaccine, largely used during the smallpox eradication campaign. After smallpox was declared eradicated, the vaccination that conferred immunity to OPV was discontinued, favoring a new contingent of susceptible individuals to OPV...
November 15, 2017: Viruses
https://www.readbyqxmd.com/read/29133154/adverse-birth-outcomes-associated-with-zika-virus-exposure-during-pregnancy-in-s%C3%A3-o-jos%C3%A3-do-rio-preto-brazil
#3
Mauricio Lacerda Nogueira, Nivison Ruy Rocha Nery Júnior, Cássia Fernanda Estofolete, Ana Carolina Bernardes Terzian, Georgia de Freitas Guimarães, Nathalia Zini, Rafael Alves da Silva, Gislaine Celestino Dutra Silva, Ligia Cosentino Junqueira Franco, Paula Rahal, Cintia Bittar, Bruno Carneiro, Pedro Fernando Vasconcelos da Costa, Daniele Freitas Henriques, Deusenia Machado Ulisses Barbosa, Patrícia Lopes Rombola, Luciana de Grande, Andréia Francesli Negri Reis, Sacha Ariane Palomares, Marcia Wakai Catelan, Lilian Elisa Arão Antonio Cruz, Silvia Helena Necchi, Rita de Cassia Vilella Mendonça, Izalco Nuremberg Penha Dos Santos, Suzimeiri Brigatti Alavarse Caron, Federico Costa, Fernando A Bozza, Antonio Soares de Souza, Cinara Cássia Brandão de Mattos, Luiz Carlos de Mattos, Nikos Vasilakis, Antonio Helio Oliani, Denise Cristina Mós Vaz Oliani, Albert Icksang Ko
OBJECTIVE: We aimed to report the first 54 cases of pregnant women infected by Zika vírus (ZIKV) and their virological and clinical outcomes, as well as the newborns' outcomes in 2016, after the emergence of ZIKV in dengue endemic areas of São Paulo, Brazil. METHODS: This is a descriptive study performed from February to October 2016 on 54 qPCR ZIKV-positive pregnant women identified by the Public Health Authority of São Jose do Rio Preto, São Paulo, Brazil...
November 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29116300/cymbopogon-citratus-essential-oil-effect-on-polymicrobial-caries-related-biofilm-with-low-cytotoxicity
#4
Maria Alcionéia Carvalho de Oliveira, Aline Chiodi Borges, Fernanda Lourenção Brighenti, Marcos José Salvador, Aline Vidal Lacerda Gontijo, Cristiane Yumi Koga-Ito
The objective of this study was to evaluate the effects of Cymbopogon citratus essential oil and its main compound (citral) against primary dental colonizers and caries-related species. Chemical characterization of the essential oil was performed by gas chromatography/mass spectroscopy (GC/MS), and the main compound was determined. Antimicrobial activity was tested against Actinomyces naeslundii, Lactobacillus acidophilus, S. gordonii, S. mitis, S. mutans, S. sanguinis and S. sobrinus. Minimum inhibitory and bactericide concentrations were determined by broth microdilution assay for streptococci and lactobacilli reference, and for clinical strains...
November 6, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/29116093/the-challenge-of-mapping-the-human-connectome-based-on-diffusion-tractography
#5
Klaus H Maier-Hein, Peter F Neher, Jean-Christophe Houde, Marc-Alexandre Côté, Eleftherios Garyfallidis, Jidan Zhong, Maxime Chamberland, Fang-Cheng Yeh, Ying-Chia Lin, Qing Ji, Wilburn E Reddick, John O Glass, David Qixiang Chen, Yuanjing Feng, Chengfeng Gao, Ye Wu, Jieyan Ma, H Renjie, Qiang Li, Carl-Fredrik Westin, Samuel Deslauriers-Gauthier, J Omar Ocegueda González, Michael Paquette, Samuel St-Jean, Gabriel Girard, François Rheault, Jasmeen Sidhu, Chantal M W Tax, Fenghua Guo, Hamed Y Mesri, Szabolcs Dávid, Martijn Froeling, Anneriet M Heemskerk, Alexander Leemans, Arnaud Boré, Basile Pinsard, Christophe Bedetti, Matthieu Desrosiers, Simona Brambati, Julien Doyon, Alessia Sarica, Roberta Vasta, Antonio Cerasa, Aldo Quattrone, Jason Yeatman, Ali R Khan, Wes Hodges, Simon Alexander, David Romascano, Muhamed Barakovic, Anna Auría, Oscar Esteban, Alia Lemkaddem, Jean-Philippe Thiran, H Ertan Cetingul, Benjamin L Odry, Boris Mailhe, Mariappan S Nadar, Fabrizio Pizzagalli, Gautam Prasad, Julio E Villalon-Reina, Justin Galvis, Paul M Thompson, Francisco De Santiago Requejo, Pedro Luque Laguna, Luis Miguel Lacerda, Rachel Barrett, Flavio Dell'Acqua, Marco Catani, Laurent Petit, Emmanuel Caruyer, Alessandro Daducci, Tim B Dyrby, Tim Holland-Letz, Claus C Hilgetag, Bram Stieltjes, Maxime Descoteaux
Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth tracts, we organized an open international tractography challenge, which resulted in 96 distinct submissions from 20 research groups. Here, we report the encouraging finding that most state-of-the-art algorithms produce tractograms containing 90% of the ground truth bundles (to at least some extent)...
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29111230/high-intensity-interval-training-modulates-hippocampal-oxidative-stress-bdnf-and-inflammatory-mediators-in-rats
#6
Daniel A Freitas, Etel Rocha-Vieira, Bruno A Soares, Luiza F Nonato, Sueli R Fonseca, Jeanne B Martins, Vanessa Amaral Mendonça, Ana C Lacerda, André R Massensini, Jacques R Poortamns, Romain Meeusen, Hércules R Leite
Although High Intensity Interval Training (HIIT) are being associated to increase cardiovascular and metabolic adaptation, there is controversy and limited information about the effects of HIIT on hippocampal oxidative stress, pro- and anti-inflammatory cytokines balance and neurotrophic status. Thus, this study evaluated the effects of six weeks of HIIT on hippocampal redox state (oxidative damage and enzymatic and non-enzymatic antioxidant defenses), neuroimmune mediators (TNFα, IL-6, IL-1β and IL-10) and brain-derived neurotrophic (BDNF) levels...
October 28, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29110687/effects-of-high-frequency-transcranial-magnetic-stimulation-on-functional-performance-in-individuals-with-incomplete-spinal-cord-injury-study-protocol-for-a-randomized-controlled-trial
#7
Amanda Vitória Lacerda de Araújo, Valéria Ribeiro Nogueira Barbosa, Gilma Serra Galdino, Felipe Fregni, Thais Massetti, Sara Lynn Fontes, Danilo de Oliveira Silva, Talita Dias da Silva, Carlos Bandeira de Mello Monteiro, James Tonks, Fernando Henrique Magalhães
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has been investigated as a new tool in neurological rehabilitation of individuals with spinal cord injury (SCI). However, due to the inconsistent results regarding the effects of rTMS in people with SCI, a randomized controlled double-blind crossover trial is needed to clarify the clinical utility and to assess the effect size of rTMS intervention in this population. Therefore, this paper describes a study protocol designed to investigate whether the use of rTMS can improve the motor and sensory function, as well as reduce spasticity in patients with incomplete SCI...
November 6, 2017: Trials
https://www.readbyqxmd.com/read/29107586/ru-fe-bimetallic-complexes-synthesis-characterization-cytotoxicity-and-study-of-their-interactions-with-dna-hsa-and-human-topoisomerase-ib
#8
Jessica E Takarada, Adriana P M Guedes, Rodrigo S Correa, Elisângela de P Silveira-Lacerda, Silvia Castelli, Federico Iacovelli, Victor Marcelo Deflon, Alzir Azevedo Batista, Alessandro Desideri
Three ruthenium/iron-based compounds, 1: [Ru(MIm)(bipy)(dppf)]PF6 (MIm = 2-mercapto-1-methylimidazole anion), 2: [RuCl(Im)(bipy)(dppf)]PF6 (Im = imidazole), and 3: [Ru(tzdt)(bipy)(dppf)]PF6 (tzdt = 1,3-thiazolidine-2-thione anion) (dppf = 1,1'-bis(diphenylphosphine)ferrocene and bipy = 2,2'-bipyridine), were synthesized, and characterized by elemental analyses, conductivity, UV/Vis, IR, (1)H, (13)C and (31)P{1H} NMR spectroscopies, and by electrochemical technique. The complex 3 was also characterized by single-crystal X-ray...
October 28, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29104033/oral-and-maxillofacial-manifestations-of-chronic-kidney-disease-mineral-and-bone-disorder-a-multicenter-retrospective-study
#9
Flávia Sirotheau Corrêa Pontes, Márcio Ajudarte Lopes, Lucas Lacerda de Souza, Diogo Dos Santos da Mata Rezende, Alan Roger Santos-Silva, Jacks Jorge, Wagner Gomes da Silva, Fábio Ramôa Pires, André Caroli Rocha, Wladimir Gushiken de Campos, Milena Coelho Fernandes Caldato, Regina Matsunaga Martin, Felipe Paiva Fonseca, Hélder Antônio Rebelo Pontes
OBJECTIVE: To describe the oral and maxillofacial manifestations of patients diagnosed with chronic kidney disease-mineral and bone disorders. STUDY DESIGN: Over a 13-year period, clinicopathologic data of patients diagnosed with CKD-MBD who had oral and maxillofacial alterations were retrieved from the files of 4 Brazilian institutions. Data included clinical, radiographic, microscopic, and biochemical findings; treatment employed; and follow-up status. RESULTS: Twenty-one cases were identified, with 13 patients diagnosed as brown tumor of hyperparathyroidism (BTH) and 8 as osteitis fibrosa/renal osteodystrophy (OF/RO) (4 of them clinically consistent with Sagliker syndrome)...
October 10, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29099306/eif3-a-factor-for-human-health-and-disease
#10
Andreia Gomes-Duarte, Rafaela Lacerda, Juliane Menezes, Luísa Romão
The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal recycling. Accordingly, deregulated eIF3 expression is associated with different pathological conditions, including cancer. In this manuscript, we discuss the interactome and function of each subunit of the human eIF3 complex. Furthermore, we review how altered levels of eIF3 subunits correlate with neurodegenerative disorders and cancer onset and development; in addition, we evaluate how such misregulation may also trigger infection cascades...
November 3, 2017: RNA Biology
https://www.readbyqxmd.com/read/29091881/phytochemical-profile-and-mechanisms-involved-in-the-anti-nociception-caused-by-the-hydroethanolic-extract-obtained-from-tocoyena-formosa-cham-schltdl-k-schum-jenipapo-bravo-leaves-in-mice
#11
Francisco Rafael Alves Santana Cesário, Thaís Rodrigues de Albuquerque, Giovana Mendes de Lacerda, Maria Rayane Correia de Oliveira, Lindaiane Bezerra Rodrigues, Anita Oliveira Brito Pereira Bezerra Martins, Aline Augusti Boligon, Lucindo José Quintans Júnior, Adriano Antunes de Souza Araújo, Mariana Lima Vale, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes
Tocoyena formosa, a small ornamental tree growing in the dry regions of central Brazil, is commonly known as 'genipapo do bravo'. This is a medicinal plant traditionally used as an analgesic for rheumatic pain, lower back pain and myalgia, however its use is carried out without scientific evidence, which thus justifies the development of studies to investigate and prove its therapeutic potential. Therefore, the objective of this study was to evaluate the phytochemical profile of Tocoyena formosa (Cham. & Schlecht...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29091110/evaluation-in-vivo-of-biocompatibility-of-differents-resin-modified-cements-for-bonding-orthodontic-bands
#12
Janaina A Mesquita, Rogério Lacerda-Santos, Gêisa A M Sampaio, Gustavo P Godoy, Cassiano F W Nonaka, Pollianna M Alves
The focus of this study was to test the hypothesis that there would be no difference between the biocompatibility of resin-modified glass ionomer cements. Sixty male Wistar rats were selected and divided into four groups: Control Group; Crosslink Group; RMO Group and Transbond Group. The materials were inserted into rat subcutaneous tissue. After time intervals of 7, 15 and 30 days morphological analyses were performed. The histological parameters assessed were: inflammatory infiltrate intensity; reaction of multinucleated giant cells; edema; necrosis; granulation reaction; young fibroblasts and collagenization...
October 26, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29071187/gadolinium-and-platinum-in-tandem-real-time-multi-modal-monitoring-of-drug-delivery-by-mri-and-fluorescence-imaging
#13
Hongguang Li, Bethany I Harriss, Alkystis Phinikaridou, Sara Lacerda, Gregory Ramniceanu, Bich-Thuy Doan, Ka-Lok Ho, Chi-Fai Chan, Wai-Sum Lo, René M Botnar, Rongfeng Lan, Cyrille Richard, Ga-Lai Law, Nicholas J Long, Ka-Leung Wong
A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r1 relaxivity of 23.4 mM(-1)s(-1) at 3T, 25 (o)C) is a photo-activated cisplatin prodrug (PtGdL) which enables real-time monitoring of anti-cancer efficacy. PtGdL is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control GdL...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/29069228/different-levels-of-brain-derived-neurotrophic-factor-and-cortisol-in-healthy-heavy-smokers
#14
C D C Neves, A C R Lacerda, L P Lima, V K S Lage, C H Balthazar, H R Leite, V A Mendonça
Studies suggest that brain-derived neurotrophic factor (BDNF) and the hypothalamic-pituitary-adrenal (HPA) axis modulate dopaminergic activity in response to nicotine and that the concentrations of BDNF and cortisol seem to be dependent on the amount and duration of smoking. Therefore, we investigated BDNF and cortisol levels in smokers ranked by daily cigarette consumption. Twenty-seven adult males (13 non-smokers and 14 smokers) participated in the study. The smokers were divided in two groups: light (n=7) and heavy smokers (n=7)...
October 19, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29069194/worker-s-surveillance-in-the-primary-care-learning-with-family-health-team-of-jo%C3%A3-o-pessoa-para%C3%A3-ba-brazil
#15
Luciana de Assis Amorim, Thais Lacerda E Silva, Horácio Pereira de Faria, Jorge Mesquita Huet Machado, Elizabeth Costa Dias
This study analyzed the Worker's Surveillance activities of Family Health teams, based on the perceptions of physicians and nurses in the city of João Pessoa. We used a 30-question questionnaire split into four blocks: data on the professional, occupational healthcare practices focusing on the production and epidemiological profile, and matrix and institutional support to the teams. A total of 179 professionals participated, 82% of them were female, and 46% aged 50 or more; 60% had worked in the area for more than 10 years...
October 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29058562/does-l-tryptophan-supplementation-reduce-chewing-deficits-in-an-experimental-model-of-cerebral-palsy
#16
Diego Cabral Lacerda, Raul Manhães-de-Castro, Kelli Nogueira Ferraz-Pereira, Ana Elisa Toscano
Children with cerebral palsy commonly present with feeding difficulties that result from multiple orofacial sequelae, especially deficits in mastication. A previous study demonstrated that perinatal protein undernutrition accentuated the chewing impact in an experimental model of cerebral palsy. Therefore, the present study investigated whether nutritional manipulation reversed or minimized the chewing sequelae in cerebral palsy. We emphasized the relevance of evaluating the therapeutic potential of nutrients, especially tryptophan supplementation, to reduce the chewing deficits that are typical of this syndrome...
October 23, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29036700/experimental-evaluation-of-neutron-shielding-materials
#17
X Campo, R Méndez, M A S Lacerda, D Garrido, M Embid, J Sanz
A new proposed design of neutron shielding material-based on the commercial material Borotron UH050 with an addition of Al(OH)3-is evaluated in order to determine if its neutron and gamma shielding properties match those of a reference material, NS4FR. Neutron and gamma dosimetry measurements are performed, as well as neutron spectrometry measurements and Monte Carlo simulations. Negligible differences are found between the materials for neutron shielding, while significant differences are found for gamma shielding...
September 28, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29032608/microrna-profiling-reveals-dysregulated-micrornas-and-their-target-gene-regulatory-networks-in-cemento-ossifying-fibroma
#18
Thaís Dos Santos Fontes Pereira, João Artur Ricieri Brito, André Luiz Sena Guimarães, Carolina Cavaliéri Gomes, Júlio Cesar Tanos de Lacerda, Wagner Henriques de Castro, Roney Santos Coimbra, Marina Gonçalves Diniz, Ricardo Santiago Gomez
BACKGROUND: Cemento-ossifying fibroma (COF) is a benign fibro-osseous neoplasm of uncertain pathogenesis, and its treatment results in morbidity. MicroRNAs (miRNA) are small non-coding RNAs that regulate gene expression and may represent therapeutic targets. The purpose of the study was to generate a comprehensive miRNA profile of COF compared to normal bone. Additionally, the most relevant pathways and target genes of differentially expressed miRNA were investigated by in silico analysis...
October 15, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29031078/structural-design-synthesis-and-pharmacological-evaluation-of-thiazoles-against-trypanosoma-cruzi
#19
Gevanio Bezerra de Oliveira Filho, Marcos Veríssimo de Oliveira Cardoso, José Wanderlan Pontes Espíndola, Dayane Albuquerque Oliveira E Silva, Rafaela Salgado Ferreira, Pollyanne Lacerda Coelho, Pâmela Silva Dos Anjos, Emanuelle de Souza Santos, Cássio Santana Meira, Diogo Rodrigo Magalhaes Moreira, Milena Botelho Pereira Soares, Ana Cristina Lima Leite
Chagas disease is one of the most significant health problems in the American continent. benznidazole (BDZ) and nifurtimox (NFX) are the only drugs approved for treatment and exhibit strong side effects and ineffectiveness in the chronic stage, besides different susceptibility among T. cruzi DTUs (Discrete Typing Units). Therefore, new drugs to treat this disease are necessary. Thiazole compounds have been described as potent trypanocidal agents. Here we report the structural planning, synthesis and anti-T...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29020124/glucose-6-phosphate-dehydrogenase-deficiency-and-the-use-of-primaquine-top-down-and-bottom-up-estimation-of-professional-costs
#20
Henry Maia Peixoto, Marcelo Augusto Mota Brito, Gustavo Adolfo Sierra Romero, Wuelton Marcelo Monteiro, Marcus Vinícius Guimarães de Lacerda, Maria Regina Fernandes de Oliveira
The aim of this study has been to study whether the top-down method, based on the average value identified in the Brazilian Hospitalization System (SIH/SUS), is a good estimator of the cost of health professionals per patient, using the bottom-up method for comparison. The study has been developed from the context of hospital care offered to the patient carrier of glucose-6-phosphate dehydrogenase (G6PD) deficiency with severe adverse effect because of the use of primaquine, in the Brazilian Amazon. The top-down method based on the spending with SIH/SUS professional services, as a proxy for this cost, corresponded to R$60...
October 5, 2017: Revista de Saúde Pública
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