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https://www.readbyqxmd.com/read/28544594/diversity-of-aromatic-hydroxylating-dioxygenase-genes-in-mangrove-microbiome-and-their-biogeographic-patterns-across-global-sites
#1
Sanderson T P de Sousa, Lucélia Cabral, Gileno Vieira Lacerda Júnior, Valéria M Oliveira
Aromatic hydrocarbons (AH), such as polycyclic aromatic hydrocarbons, are compounds largely found in nature. Aromatic-ring-hydroxylating dioxygenases (ARHD) are proteins involved in AH degradation pathways. We used ARHD functional genes from an oil-impacted mangrove area and compared their diversity with other sites around the world to understand the ARHD biogeographic distribution patterns. For this, a comprehensive database was established with 166 operational protein families (OPFs) from 1,758 gene sequences obtained from 15 different sites worldwide, of which twelve are already published studies and three are unpublished...
May 23, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28540556/the-use-of-bacterial-bioremediation-of-metals-in-aquatic-environments-in-the-twenty-first-century-a-systematic-review
#2
Feliphe Lacerda Souza de Alencar, Julio Alejandro Navoni, Viviane Souza do Amaral
Metal pollution is a current environmental issue as a consequence of unregulated anthropic activiy. A wide range of bioremediation strategies have been successfully implemented to recover contaminated areas. Among them, bacterial bioremediation stands out as a promising tool to confront these types of concerns. This study aimed to compare and discuss worldwide scientific evolution of bacterial potential for metal bioremediation in aquatic ecosystems. The study consisted of a systematic review, elaborated through a conceptual hypothesis model, during the period from 2000 to 2016, using PubMed, MEDLINE, and SciELO databases as data resources...
May 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28538797/-evaluation-of-municipal-administration-of-healthcare-actions-for-the-elderly
#3
Keila Cristina Rausch Pereira, Josimari Telino de Lacerda, Sonia Natal
Aging individuals can experience frailty and loss of independence and autonomy. Healthcare for the elderly should help them recover their health and maintain their autonomy, in keeping with the Brazilian Statute of the Elderly and underlying policies in the Brazilian Unified National Health System. Based on a multiple case study, the objective was to assess the capacity of municipal administration to provide healthcare for the elderly. The assessment was oriented by an evaluative model validated by experts in administration and evaluation, with 16 indicators analyzing political, organizational, technical, and operational factors...
May 18, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28534168/father-s-obesity-programs-the-adipose-tissue-in-the-offspring-via-the-local-renin-angiotensin-system-and-mapks-pathways-especially-in-adult-male-mice
#4
Fernanda Ornellas, Isabele Bringhenti, Brenda Akemi N F Mattos, Carlos Alberto Mandarim-de-Lacerda, Marcia Barbosa Aguila
PURPOSE: Studies demonstrated the influence of mother's obesity on offspring. However, the father is also related to programming the future generation. The study aimed to evaluate the effects of father's obesity upon white adipose tissue (WAT) remodeling, resulting in activation of signaling pathways and inflammation in male and female offspring. METHODS: Male C57BL/6 mice received control diet (lean father group; 17% energy from lipids) or high-fat diet (obese father group; 49% energy from lipids) for 8 weeks before mating...
May 22, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28515791/vildagliptin-has-the-same-safety-profile-as-a-sulfonylurea-on-bone-metabolism-and-bone-mineral-density-in-post-menopausal-women-with-type-2-diabetes-a-randomized-controlled-trial
#5
Andre Gustavo Daher Vianna, Claudio Silva de Lacerda, Luciana Muniz Pechmann, Michelle Garcia Polesel, Emerson Cestari Marino, Victoria Zeghbi Cochenski Borba, Fellype de Carvalho Barreto
BACKGROUND: Several antidiabetic therapies affect bone metabolism. Sulfonylureas have the lowest impact on bone among oral antidiabetics. The objective of this study is to compare the effects of vildagliptin and gliclazide modified release (MR) on bone turnover markers (BTMs) and bone mineral density (BMD) in postmenopausal women with uncontrolled type 2 diabetes (T2D). METHODS: Forty-two postmenopausal women with uncontrolled T2D were randomly allocated into vildagliptin or gliclazide MR (control) groups...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28515344/kidney-brain-axis-inflammatory-cross-talk-from-bench-to-bedside
#6
REVIEW
Aline Silva Miranda, Thiago Macedo Cordeiro, Thomas Mucida Dos Santos Lacerda Soares, Rodrigo Novaes Ferreira, Ana Cristina Simões E Silva
Epidemiologic data suggest that individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing neuropsychiatric disorders, cognitive impairment, and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including cytokine/chemokine release, production of reactive oxygen species (ROS), circulating and local formation of trophic factors and of renin-angiotensin system (RAS) molecules, could also be involved, especially in the absence of obvious cerebrovascular disease...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28510253/feline-immunodeficiency-virus-and-feline-leukemia-virus-frequency-and-associated-factors-in-cats-in-northeastern-brazil
#7
L C Lacerda, A N Silva, J S Freitas, R D S Cruz, R A Said, A D Munhoz
Our aims were to determine the frequencies of feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) in owned and stray cats in the northeastern region of Brazil, ascertain the status of FeLV infection, and investigate potential associated factors among the owned cats. Blood samples from 200 asymptomatic owned cats and 30 stray cats were processed using nested PCR and commercial immunochromatographic tests to diagnose infections. To evaluate the factors associated with FIV and/or FeLV in owned cats, a semi-structured interview was conducted with each owner about the animal's environment, and these data were subjected to unconditional logistic regression...
May 10, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28506466/impaired-steroidogenesis-in-the-testis-of-leptin-deficient-mice-ob-ob
#8
Fabiane Ferreira Martins, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
The obesity and its comorbidities, including resistance to leptin, impacts the reproductive function. Testes express leptin receptors in the germ cells and Leydig cells. Then, leptin-deficient animals are obese and infertile. We aimed to evaluate the structure and steroidogenic pathway of the testis of deficient leptin mice. Three months old male C57BL/6 mice (wild-type, WT) and deficient leptin (ob/ob) mice had their testes dissected and prepared for analyses. Compared to the WT group, the ob/ob group showed a greater body mass with smaller testes, and alterations in the germinative epithelium: fewer spermatogonia, spermatocytes, and spermatids...
May 13, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28505535/thiosemicarbazones-and-4-thiazolidinones-indole-based-derivatives-synthesis-evaluation-of-antiproliferative-activity-cell-death-mechanisms-and-topoisomerase-inhibition-assay
#9
Jamerson Ferreira de Oliveira, Talitha Santos Lima, Débora Barbosa Vendramini-Costa, Sybelle Christianne Batista de Lacerda Pedrosa, Elizabeth Almeida Lafayette, Rosali Maria Ferreira da Silva, Sinara Monica Vitalino de Almeida, Ricardo Olímpio de Moura, Ana Lúcia Tasca Gois Ruiz, João Ernesto de Carvalho, Maria do Carmo Alves de Lima
In this study, we report the synthesis and structural characterization of a series of thiosemicarbazone and 4-thiazolidinones derivatives, as well as their in vitro antiproliferative activity against eight human tumor cell lines. For the most potent compound further studies were performed evaluating cell death induction, cell cycle profile, ctDNA interaction and topoisomerase IIα inhibition. A synthetic three-step route was established for compounds (2a-e and 3a-d) with yields ranging from 32 to 95%. Regarding antiproliferative activity, compounds 2a-e and 3a-d showed mean GI50 values ranging between 1...
May 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28495843/treating-fructose-induced-metabolic-changes-in-mice-with-high-intensity-interval-training-insights-in-the-liver-white-adipose-tissue-and-skeletal-muscle
#10
Victor Faria Motta, Thereza Lonzetti Bargut, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Fructose-rich caloric sweeteners induce adverse changes in the population metabolism. The study evaluated the effects of high-intensity interval training (HIIT) on a fructose feeding model, focusing on the liver, white adipose tissue (WAT), skeletal muscle, and their interplay. Male C57BL/6 mice were fed for 18 weeks one of the following diets: control (C; 5 % of total energy from fructose), or fructose (F; 55 % of total energy from fructose). In the 10th week, for an additional eight-week period the groups were divided into non-trained (NT) or HIIT groups, totaling four groups: C-NT, C-HIIT, F-NT, and F-HIIT...
May 11, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28492780/-epidemiological-profile-of-traffic-accidents-in-mar%C3%A3-lia-s%C3%A3-o-paulo-state-brazil-2012
#11
Carina Rejane Fernandes Biffe, Airi Harada, Alexander Bocchi Bacco, Carine Silveira Coelho, João Lucas Ferrareto Baccarelli, Karoline Lopes Silva, Luzmarina Aparecida Doretto Braccialli, Margarete Beloni, Maria Luiza Guidinho Bernardes, Stephanie Ribeiro Lacerda, Thainá Inoue Silva
OBJECTIVE: to describe the profile of victims of traffic accidents and traffic-related deaths in Marília-SP, Brazil. METHODS: this is a descriptive study, based on data from police reports (PR) and Death Certificates (DC), in 2012. RESULTS: 1,537 PR were gathered; among the 3,257 individuals involved in traffic accidents, 67.3% were men, and 53.3% were between 20-39 years of age; most accidents occurred on road intersections (35.2%), at 8 a...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28492774/the-burden-of-cardiovascular-diseases-in-santa-catarina-state-brazil-in-2009
#12
Jefferson Traebert, Leandro Giacomello, Áureo Dos Santos, Daniel Fernandes Martins, Eliane Traebert, Josimari Telino de Lacerda
OBJECTIVE: to estimate the burden of cardiovascular diseases in Santa Catarina State, Brazil. METHODS: this is an ecological study with the nine health macroregions of the state as units of analysis; the number of years of life lost, the number of years lived with disability and the number disability-adjusted life years (DALYs) for 2009 were estimated. RESULTS: a total of 358,777 DALYs were estimated, with a rate of 5,852 DALYs/100,000 inhabitants, 51...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28492719/does-aortic-valve-repair-in-valve-sparing-aortic-root-reconstruction-compromise-the-longevity-of-the-procedure
#13
Ricardo Ribeiro Dias, José Augusto Duncan, Fabrício José de Souza Dinato, Lucas Lacerda Araújo, Hugo Monteiro Neder Issa, Fábio Fernandes, Charles Mady, Fábio Biscegli Jatene
OBJECTIVES: The effect of performing aortic valve repair in combination with valve-sparing operation on the length of time for which patients are free from reoperation is unclear. The objective of this study was to determine if the performance of aortic valve repair during valve-sparing operation modified the freedom from reoperation time. METHODS: From January 2003 to July 2014, 78 patients with a mean age of 49±15 years underwent valve-sparing operation. Sixty-eight percent of these patients were male...
April 2017: Clinics
https://www.readbyqxmd.com/read/28489166/anatomic-variations-of-hepatic-artery-a-study-in-479-liver-transplantations
#14
Olival Cirilo Lucena da Fonseca-Neto, Heloise Caroline de Souza Lima, Priscylla Rabelo, Paulo Sérgio Vieira de Melo, Américo Gusmão Amorim, Cláudio Moura Lacerda
Background: The incidence of anatomic variations of hepatic artery ranges from 20-50% in different series. Variations are especially important in the context of liver orthotopic transplantation, since, besides being an ideal opportunity for surgical anatomical study, their precise identification is crucial to the success of the procedure. Aim: To identify the anatomical variations in the hepatic arterial system in hepatic transplantation. Methods: 479 medical records of transplanted adult patients in the 13-year period were retrospectively analyzed, and collected data on hepatic arterial anatomy of the deceased donor...
January 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28480600/ophthalmic-parameters-in-adult-lowland-paca-cuniculus-paca-raised-in-captivity
#15
Camila P Balthazar da Silveira, Tiago B Lima, Roberta M Crivelaro, Luciana C C de Lacerda, Ivan R M Pádua, Roberta Renzo, Alexandre A F de Barros Sobrinho, Fabrício S Oliveira, Marcela Aldrovani, José L Laus
OBJECTIVE: To investigate the ophthalmic parameters of lowland pacas, including the anatomic features, tear production, intraocular pressure, central corneal thickness, and morphology of the corneal endothelium. ANIMALS STUDIED: Thirteen adult, anesthetized Cuniculus paca. PROCEDURE: Eyes were evaluated using slit-lamp biomicroscopy, the Schirmer tear test I, digital applanation tonometry, binocular indirect ophthalmoscopy, and noncontact specular microscopy...
May 8, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28470934/lanthanide-complexes-in-molecular-magnetic-resonance-imaging-and-theranostics
#16
Eva Toth, Sara Lacerda
Lanthanide complexes have attracted continuous attention in the biomedical field and today various imaging applications make use of their versatile magnetic and luminescence properties. In this minireview, we give insights into the mechanistic aspects that allow modulating the relaxation or chemical exchange saturation transfer (CEST) features, thus the MRI efficiency of paramagnetic lanthanide chelates in order to create agents that are capable of providing an MRI response as a function of a specific biomarker...
May 4, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28447334/-1-h-nmr-1-h-nmr-t2-edited-and-2d-nmr-in-bipolar-disorder-metabolic-profiling
#17
Sumit Sethi, Mariana Pedrini, Lucas B Rizzo, Maiara Zeni-Graiff, Caroline Dal Mas, Ana Cláudia Cassinelli, Mariane N Noto, Elson Asevedo, Quirino Cordeiro, João G M Pontes, Antonio J M Brasil, Acioly Lacerda, Mirian A F Hayashi, Ronei Poppi, Ljubica Tasic, Elisa Brietzke
BACKGROUND: The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics. METHODS: Metabolomic profiling, employing (1)H-NMR, (1)H-NMR T2-edited, and 2D-NMR spectroscopy and chemometrics of human blood serum samples from patients with bipolar disorder (n = 26) compared with healthy volunteers (n = 50) was performed. RESULTS: The investigated groups presented distinct metabolic profiles, in which the main differential metabolites found in the serum sample of bipolar disorder patients compared with those from controls were lipids, lipid metabolism-related molecules (choline, myo-inositol), and some amino acids (N-acetyl-L-phenyl alanine, N-acetyl-L-aspartyl-L-glutamic acid, L-glutamine)...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28425875/occurrence-of-qnrb1-and-qnrb12-genes-mutation-in-gyra-and-ramr-and-expression-of-efflux-pumps-in-isolates-of-klebsiella-pneumoniae-carriers-of-blakpc-2
#18
Alexsandra Maria Lima Scavuzzi, Maria Amélia Vieira Maciel, Heloísa Ramos Lacerda de Melo, Luiz Carlos Alves, Fábio André Brayner, Ana Catarina Souza Lopes
PURPOSE: The occurrence of quinolone-resistance genes (qnrA, qnrB and qnrS), the presence of mutations in gyrA, gyrB and parC, as well as the expression of efflux pumps (acrB and acrF) and mutations in the gene ramR. METHODOLOGY: Were investigated in 30 blaKPC-2-positive isolates of Klebsiella pneumoniae taken from infection and colonization in hospital patients from Recife-PE, Brazil. The detection of the qnr, acrB and acrF genes and analysis of the mutations in ramR and the quinolone-resistance-determining regions of gyrA, gyrB and parC were performed by PCR followed by DNA sequencing...
April 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28425872/increase-in-human-immunodeficiency-virus-1-diversity-and-detection-of-various-subtypes-and-recombinants-in-north-eastern-brazil
#19
Kledoaldo Lima, Élcio Leal, Ana Maria Salustiano Cavalcanti, Daniela Medeiros Salustiano, Luzidalva Barbosa de Medeiros, Sirleide Pereira da Silva, Heloísa Ramos Lacerda
PURPOSE: Diverse human immunodeficiency virus 1 (HIV-1) subtypes and circulating recombinant forms are found in Brazil. The majority of HIV-1 molecular epidemiological studies in Brazil have been conducted in the southern and south-eastern regions of the country, although several recent studies in the north-eastern region have addressed this issue. The objective of this study was to molecularly characterize HIV-1 circulating in Pernambuco, north-eastern Brazil. METHODOLOGY: A total of 64 samples were collected from 2002 to 2003, and another 103 were collected from 2007 to 2009...
April 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28422366/oral-paracoccidioidomycosis-retrospective-analysis-of-55-brazilian-patients
#20
Aline Heloísa Trindade, Henrique Côrtes Meira, Igor Figueiredo Pereira, Julio César Tanos de Lacerda, Ricardo Alves de Mesquita, Vagner Rodrigues Santos
Paracoccidioidomycosis (PCM) is a rare fungal infection in the world, but endemic and acquired exclusively in Latin America, with the highest prevalence in South America and Brazil, particularly. Changes in oral cavity are common and constitute the first clinical manifestation in many patients. The aim of this study was to describe the prevalence of oral PCM and analyse the profile of the disease and patients. Retrospective research, consisting of information present in the medical records in the period 1998-2015, whose histopathological diagnosis was oral PCM...
April 19, 2017: Mycoses
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