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https://www.readbyqxmd.com/read/28820410/-changing-of-stillbirth-risks-in-different-options-of-its-registration
#1
S Mamedova
Purpose of the study - comparing of stillbirth rates and some of its risk factors in different options (after 22 and 28 completed weeks of gestation) of its registration. This study was conducted on the basis of a regional prenatal centre. Monitoring was conducted retrospectively with continuous coverage of all cases of completed pregnancy after 22 completed weeks of gestation. Stillbirth coefficient was calculated based on body weight (500 grams or more - I option, and a 1000 grams - II option) based on 100 of all birth cases (corresponding to 500 grams body weight or more, and 1,000 grams or more)...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28819941/maternal-and-neonatal-outcomes-of-pregnancy-at-39-weeks-and-beyond-with-mild-gestational-diabetes-mellitus
#2
Hanqing Chen, Suhua Zou, Jianbo Yang, Songqing Deng, Jian Cai, Zilian Wang
OBJECTIVES: The purpose of this study was to retrospectively analyze maternal and neonatal outcomes in pregnant women with mild gestational diabetes mellitus at 39 weeks compared to 40 weeks. MATERIAL AND METHODS: Clinical data of 372 cases of mild gestational diabetes mellitus form First Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively. There were 108 mild GDM patients that delivered at 40-40+6 weeks in our research group, and 264 patients that delivered in 39-39+6 weeks in the control group...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28819576/pitfall-in-the-diagnosis-of-diabetes-insipidus-and-pregnancy
#3
Melissa Sum, Jessica B Fleischer, Alexander G Khandji, Sharon L Wardlaw
Diabetes insipidus (DI) during pregnancy and the perinatal period is an uncommon medical problem characterized by polyuria and excessive thirst. Diagnosis of DI may be overlooked in the setting of pregnancy, a time when increased water intake and urine output are commonly reported. We report two cases: one of transient DI in a young woman during her third trimester of twin pregnancy in association with acute fatty liver and hypertension and one of postpartum DI secondary to Sheehan syndrome from rupture of a splenic artery aneurysm...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28817576/gestational-diabetes-mellitus-is-associated-with-increased-pro-migratory-activation-of-vascular-endothelial-growth-factor-receptor-2-and-reduced-expression-of-vascular-endothelial-growth-factor-receptor-1
#4
Felipe Troncoso, Jesenia Acurio, Kurt Herlitz, Claudio Aguayo, Patricio Bertoglia, Enrique Guzman-Gutierrez, Marco Loyola, Marcelo Gonzalez, Meriem Rezgaoui, Gernot Desoye, Carlos Escudero
Placentas from gestational diabetes mellitus (GDM) are often hypervascularized; however, participation of vascular endothelial growth factor (VEGF) and its receptors in this placental adaptation is unclear. We aimed to test whether changes in phosphorylation of tyrosine 951 or tyrosine 1175 (pY951 or pY1175) of the vascular endothelial growth factor receptor 2 (KDR) are associated with the proangiogenic state observed in placentas from GDM. We obtained placental samples from women with normal pregnancies (n = 24) or GDM (n = 18)...
2017: PloS One
https://www.readbyqxmd.com/read/28817230/recent-findings-on-fulminant-type-1-diabetes
#5
REVIEW
Lan Liu, Ling Zeng, Dan Sang, Zeyuan Lu, Jie Shen
Fulminant type 1 diabetes (fT1D) is a new subtype of type 1 diabetes proposed by Imagawa in 2000. It is a clinical syndrome characterized by a markedly rapid and almost complete destruction of pancreatic β cells. Metabolic derangement is more severe in this subtype than in autoimmune type 1 diabetes. The incidence of fT1D is associated with HLA DRB1*04:05DQB1*04:01, both innate and acquired immune disorders might contribute to the development of fT1D. The presence of specific innate immune responses to enterovirus infection connected with enhanced adoptive immune pathways responsible for aggressive β cell toxicity in fT1D...
August 17, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28810587/association-of-polycystic-ovary-syndrome-with-metabolic-syndrome-and-gestational-diabetes-aggravated-complication-of-pregnancy
#6
Kui Yao, Ce Bian, Xia Zhao
Polycystic ovary syndrome (PCOS) affects 5-20% of the reproductive age women globally. PCOS is diagnosed by the presence of hyperandrogenism, oligo-anovulation, and polycystic morphology of at least one ovary. Insulin resistance (IR), hyperinsulinemia and associated metabolic abnormalities including metabolic syndrome play a significant role in the development of PCOS. The chances of developing MS in PCOS women was shown to increase by almost 14-fold in patients with increasing body mass index. Even in the absence of overt obesity, a preferential deposition of intra-abdominal fat is noted in PCOS women and this intra-abdominal fat leads to impaired insulin action and functional IR and hyperandrogenism...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810177/use-of-atypical-antipsychotics-in-pregnancy-and-maternal-gestational-diabetes
#7
Alice Panchaud, Sonia Hernandez-Diaz, Marlene P Freeman, Adele C Viguera, Sarah C MacDonald, Alexandra Z Sosinsky, Lee S Cohen
BACKGROUND: Second generation antipsychotic medications (SGAs) are widely used by reproductive-age women to treat a number of psychiatric illnesses. Some SGAs have been associated with an increased risk of developing diabetes, although information regarding their diabetogenic effect in pregnant women is scarce. OBJECTIVE: To evaluate the risk of gestational diabetes (GDM) among women treated with SGA. METHOD: The Massachusetts General Hospital (MGH) National Pregnancy Registry for Atypical Antipsychotics (NPRAA) collects data on drug use, pregnancy outcomes, and other characteristics from pregnant women, ages 18-45 years, using 3 phone interviews conducted at (1) enrollment during pregnancy, (2) 7 months' gestation, and (3) 2-3 months postpartum...
July 29, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28810088/the-impact-of-maternal-diabetes-obesity-and-race-on-infant-birth-weights-in-south-dakota
#8
Kari L Halvorson, H Bruce Vogt, Lon Kightlinger, Dennis Stevens
INTRODUCTION: Maternal obesity, high gestational weight gain and diabetes mellitus during pregnancy are known risk factors that correlate with high infant birth weight and the mother's race. Previous studies have focused on low birth weight, prematurity and infant mortality. This study examined the interaction between race, maternal risk factors and high infant birth weights at the population level in South Dakota to identify factors contributing to the high Native American infant birth weights...
February 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28808645/effect-of-vitamin-d-supplementation-on-the-incidence-of-gestational-diabetes
#9
Hatav Ghasemi Tehrani, Fatemeh Mostajeran, Behnaz Banihashemi
BACKGROUND: The aim of this study was survey of the effect of Vitamin D supplementation on the incidence of gestational diabetes (GDM) in pregnant women. MATERIALS AND METHODS: This randomized clinical trial was conducted at Alzahra and Shahid Beheshti Hospital in Isfahan, Iran, from January, 2013 to January, 2014 on 210 pregnant women referred to gynecology clinics. Serum levels of Vitamin D were measured, and those with lower serum levels of 10 nmol/L randomly divided into two groups of A and B...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28807878/sex-dependent-changes-in-lipid-metabolism-ppar-pathways-and-micrornas-that-target-ppars-in-the-fetal-liver-of-rats-with-gestational-diabetes
#10
Daiana Fornes, Verónica White, Romina Higa, Florencia Heinecke, Evangelina Capobianco, Alicia Jawerbaum
Gestational diabetes mellitus (GDM) is a prevalent disease that impairs fetal metabolism and development. We have previously characterized a rat model of GDM induced by developmental programming. Here, we analyzed lipid content, the levels of the three PPAR isotypes and the expression of microRNAs that regulate PPARs expression in the liver of male and female fetuses of control and GDM rats on day 21 of pregnancy. We found increased levels of triglycerides and cholesterol in the livers of male fetuses of GDM rats compared to controls, and, oppositely, reduced levels of triglycerides, cholesterol, phospholipids and free fatty acids in the livers of female fetuses of GDM rats compared to controls...
August 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28806491/the-association-between-dysregulated-adipocytokines-in-early-pregnancy-and-development-of-gestational-diabetes
#11
Sally K Abell, Soulmaz Shorakae, Cheryce L Harrison, Danielle Hiam, Alba Moreno-Asso, Nigel K Stepto, Barbora De Courten, Helena J Teede
BACKGROUND: To investigate the association of adipocytokines and other inflammatory markers with development of GDM. METHODS: Serum adipocytokines and inflammatory markers were studied at 12-15 weeks gestation using biobanked control samples from a randomised trial. Study participants were identified as high risk for GDM using a validated clinical risk prediction tool. Markers were tested using commercial ELISA kits for high molecular weight (HMW) adiponectin, interleukin-6 (IL-6), plasminogen activator inhibitor-1, visfatin, omentin-1, sex-hormone binding globulin, monocyte chemoattractant protein and asymmetrical dimethylarginine...
August 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28805180/diabetes-and-pregnancy-in-wistar-rats-renal-effects-for-mothers-in-the-postpartum-period
#12
N França-Silva, N G Reis, P F Santos, A P C Balbi
In this study, diabetes mellitus (DM) was induced in Wistar rats during pregnancy and maintained in the postpartum period (PP) and we evaluated systolic blood pressure (SBP), glomerular filtration rate (GFR) and renal immunohistochemical and morphometric studies from different groups: G1 (non-pregnant control rats), G2 (non-pregnant diabetic rats), G3 (control mothers) and G4 (diabetic mothers). We found that there were no differences in relation to SBP, but there was a tendency for reduction in GFR from G4 compared with the other groups (G)...
August 14, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28804631/the-influence-of-d-chiro-inositol-and-d-myo-inositol-in-pregnant-women-with-glucose-intolerance
#13
Domenico Dell'Edera, Francesca Sarlo, Arianna Allegretti, Francesca Simone, Maria Giovanna Lupo, Annunziata Anna Epifania
The aim of the present study was to demonstrate that the use of inositol and folic acid from the first trimester of pregnancy, counteracts the onset of gestational diabetes mellitus (GDM) in women at risk, preserving the infants from macrosomia, hypoglycemia and preterm delivery. The authors collected data from the pregnant women at the laboratory (Unit of Cytogenic and Molecular Genetics), from January 2014 to April 2016, all with first trimester fasting plasma glucose (FPG) >92 mg/dl. A total of 40 women were treated with 250 mg/day D-chiro-inositol, 1...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28801435/differences-in-the-pregnancy-gestation-period-and-mean-birth-weights-in-infants-born-to-indian-pakistani-bangladeshi-and-white-british-mothers-in-luton-uk-a-retrospective-analysis-of-routinely-collected-data
#14
Rebecca Garcia, Nasreen Ali, Andy Guppy, Malcolm Griffiths, Gurch Randhawa
OBJECTIVE: To compare mean birth weights and gestational age at delivery of infants born to Indian, Pakistani, Bangladeshi and white British mothers in Luton, UK. DESIGN: Retrospective analysis using routinely recorded secondary data in Ciconia Maternity information System, between 2008 and 2013. SETTING: Luton, UK. PARTICIPANTS: Mothers whose ethnicity was recorded as white British, Bangladeshi, Pakistani or Indian and living in Luton, aged over 16, who had a live singleton birth over 24 weeks of gestation were included in the analysis (n=14 871)...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801424/a-cost-effectiveness-comparison-of-the-nice-2015-and-who-2013-diagnostic-criteria-for-women-with-gestational-diabetes-with-and-without-risk-factors
#15
Paul Brian Jacklin, Michael Ja Maresh, Chris C Patterson, Katharine P Stanley, Anne Dornhorst, Shona Burman-Roy, Rudy W Bilous
OBJECTIVES: To compare the cost-effectiveness (CE) of the National Institute for Health and Care Excellence (NICE) 2015 and the WHO 2013 diagnostic thresholds for gestational diabetes mellitus (GDM). SETTING: The analysis was from the perspective of the National Health Service in England and Wales. PARTICIPANTS: 6221 patients from four of the Hyperglycaemia and Adverse Pregnancy Outcomes (HAPO) study centres (two UK, two Australian), 6308 patients from the Atlantic Diabetes in Pregnancy study and 12 755 patients from UK clinical practice...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28800568/causes-and-consequences-of-gestational-diabetes-in-south-asians-living-in-canada-results-from-a-prospective-cohort-study
#16
Sonia S Anand, Milan Gupta, Koon K Teo, Karleen M Schulze, Dipika Desai, Nora Abdalla, Michael Zulyniak, Russell de Souza, Gita Wahi, Mateen Shaikh, Joseph Beyene, Eileen de Villa, Katherine Morrison, Sarah D McDonald, Hertzel Gerstein
BACKGROUND: The reasons for the increased risk of gestational diabetes among South Asian women are not well understood. We sought to identify the determinants of gestational diabetes and its impact on newborn health in a prospective birth cohort of South Asian women and their babies. METHODS: As part of the South Asian Birth Cohort (START) prospective birth cohort study in Ontario, we recruited 1012 South Asian women with singleton pregnancies in the second trimester of pregnancy between July 11, 2011, and Nov...
August 9, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28799164/preconception-care-for-diabetic-women-for-improving-maternal-and-infant-health
#17
REVIEW
Joanna Tieu, Philippa Middleton, Caroline A Crowther, Emily Shepherd
BACKGROUND: Infants born to mothers with pre-existing type 1 or type 2 diabetes mellitus are at greater risk of congenital anomalies, perinatal mortality and significant morbidity in the short and long term. Pregnant women with pre-existing diabetes are at greater risk of perinatal morbidity and diabetic complications. The relationship between glycaemic control and health outcomes for both mothers and infants indicates the potential for preconception care for these women to be of benefit...
August 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28799123/application-of-one-step-iadpsg-versus-two-step-diagnostic-criteria-for-gestational-diabetes-in-the-real-world-impact-on-health-services-clinical-care-and-outcomes
#18
REVIEW
Florence M Brown, Jennifer Wyckoff
PURPOSE OF REVIEW: This paper seeks to summarize the impact of the one-step International Association of Diabetes and Pregnancy Study Groups (IADPSG) versus the two-step gestational diabetes mellitus (GDM) criteria with regard to prevalence, outcomes, healthcare delivery, and long-term maternal metabolic risk. RECENT FINDINGS: Studies demonstrate a 1.03-3.78-fold rise in the prevalence of GDM with IADPSG criteria versus baseline criteria. Women with GDM by IADPSG criteria have more adverse pregnancy outcomes than women with normal glucose tolerance (NGT)...
August 10, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28798896/pregnancy-outcomes-in-hiv-infected-women-experience-from-a-tertiary-care-center-in-india
#19
Vatsla Dadhwal, Aparna Sharma, Kavita Khoiwal, Dipika Deka, Plaboni Sarkar, P Vanamail
BACKGROUND AND OBJECTIVES: There is conflicting data on the effect of HIV infection as well as antiretroviral therapy (ART) on pregnancy outcome. The objectives of this study were to compare pregnancy outcomes in women with and without HIV infection, and to evaluate the effect of HAART on pregnancy in HIV-infected women. METHODS: This is a prospective case record analysis of 212 HIV-infected women delivering between 2002 and 2015, in a tertiary health care center in India...
2017: International Journal of MCH and AIDS
https://www.readbyqxmd.com/read/28798085/the-association-of-falling-insulin-requirements-with-maternal-biomarkers-and-placental-dysfunction-a-prospective-study-of-women-with-pre-existing-diabetes-in-pregnancy
#20
Suja Padmanabhan, Vincent W Lee, Mark Mclean, Neil Athayde, Valeria Lanzarone, Qemer Khoshnow, Michael J Peek, N Wah Cheung
OBJECTIVE: To investigate the association of falling insulin requirements (FIR) among women with pre-existing diabetes with adverse obstetric outcomes and maternal biomarkers longitudinally in pregnancy. RESEARCH DESIGN AND METHODS: A multicenter prospective cohort study of 158 women (41 with type 1 diabetes and 117 with type 2 diabetes) was conducted. Women with FIR of ≥15% from the peak total daily dose after 20 weeks gestation were considered case subjects (n = 32)...
August 10, 2017: Diabetes Care
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