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3d printing kidney

Friedrich-Carl von Rundstedt, Jason M Scovell, Smriti Agrawal, Jacques Zaneveld, Richard E Link
OBJECTIVE: Surgical planning for robotic partial nephrectomy (RALPN) depends on preoperative imaging and interpretation of spatial relationships between tumor and renal anatomy. We describe our experience using patient specific tissue-like kidney models created with advanced 3D printing technology for preoperative planning and surgical rehearsal prior to RALPN . PATIENTS AND METHODS: A feasibility study of 10 patients with solid renal masses who underwent RALPN after preoperative rehearsal using 3D print models...
November 10, 2016: BJU International
Fabian Adams, Tian Qiu, Andrew Mark, Benjamin Fritz, Lena Kramer, Daniel Schlager, Ulrich Wetterauer, Arkadiusz Miernik, Peer Fischer
Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology and the physical properties of human organs. In this paper, we report a novel fabrication process to make a human kidney phantom with realistic anatomical structures and physical properties. The detailed anatomical structure was directly acquired from high resolution CT data sets of human cadaveric kidneys...
November 9, 2016: Annals of Biomedical Engineering
Yasser A Noureldin, Sero Andonian
OBJECTIVES: Percutaneous renal access (PCA) is a challenging step during percutaneous nephrolithotomy. The aim of this study is to review the literature for different types of simulators described for PCA. METHODS: Databases of Medline, Embase, Cochrane Library, OvidSP, and Google Scholar were systematically searched until May 2016. The studies were analyzed regarding the type of simulator (nonbiologic, biologic, live animal, and virtual reality [VR]), type of validity (face, content, construct, and predictive), cost-effectiveness, and whether these simulators have been used for training and/or assessment of PCA...
October 11, 2016: Journal of Endourology
T Smektala, A Goląb, M Królikowski, M Slojewski
OBJECTIVE: The aim of this brief report was to present and evaluate workflow of preparation of lowcost individual silicone replicas of kidneys for laparoscopic training and surgical simulation of difficult nephron sparing surgeries. METHODS: The work flow consists of four steps: 1.Image segmentation; 2.Casting mould designing; 3.Manufacturing of casting mould; 4.Silicone replica casting. To evaluate the cost and time required to execute the presented method, authors prepared 5 silicone models for 5 consecutive patients undergoing laparoscopic kidney tumorectomy due to renal cell cancer...
September 2016: Archivos Españoles de Urología
Adam Golab, Marcin Slojewski, Miroslaw Brykczynski, Magdalena Lukowiak, Marek Boehlke, Daniel Matias, Tomasz Smektala
Three-dimensional (3D) printing involves preparing 3D objects from a digital model. These models can be used to plan and practice surgery. We used 3D printing to plan for a rare complicated surgery involving the removal of a renal tumor and neoplastic mass, which reached the heart atrium. A printed kidney model was an essential element of communication for physicians with different specializations.
2016: Heart Surgery Forum
Hasan Anıl Atalay, Volkan Ülker, İlter Alkan, Halil Lütfi Canat, Ünsal Özkuvancı, Fatih Altunrende
OBJECTIVE: To investigate the impact of three-dimensional (3D) printed pelvicaliceal system models on residents' understanding of pelvicaliceal system anatomy before percutaneous nephrolithotripsy (PCNL). MATERIALS AND METHODS: Patients with unilateral complex renal stones indicating PCNL were selected. Usable data of patients were obtained from CT-scans in Digital Imaging and Communications in Medicine (DICOM) format. Mimics software version 16.0 (Materialise, Belgium) was used for segmentation and extraction of pelvicaliceal systems (PCSs)...
October 2016: Journal of Endourology
Johannes Tran-Gia, Susanne Schlögl, Michael Lassmann
: Currently, the validation of multimodal quantitative imaging and absorbed dose measurements is impeded by the lack of suitable, commercially available anthropomorphic phantoms of variable sizes and shapes. To demonstrate the potential of 3-dimensional (3D) printing techniques for quantitative SPECT/CT imaging, a set of kidney dosimetry phantoms and their spherical counterparts was designed and manufactured with a fused-deposition-modeling 3D printer. Nuclide-dependent SPECT/CT calibration factors were determined to assess the accuracy of quantitative imaging for internal renal dosimetry...
December 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Andrew P Robinson, Jill Tipping, David M Cullen, David Hamilton, Richard Brown, Alex Flynn, Christopher Oldfield, Emma Page, Emlyn Price, Andrew Smith, Richard Snee
BACKGROUND: Patient-specific absorbed dose calculations for molecular radiotherapy require accurate activity quantification. This is commonly derived from Single-Photon Emission Computed Tomography (SPECT) imaging using a calibration factor relating detected counts to known activity in a phantom insert. METHODS: A series of phantom inserts, based on the mathematical models underlying many clinical dosimetry calculations, have been produced using 3D printing techniques...
December 2016: EJNMMI Physics
Anh-Vu Do, Adil Akkouch, Brian Green, Ibrahim Ozbolat, Amer Debabneh, Sean Geary, Aliasger K Salem
Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC)...
May 27, 2016: Annals of Biomedical Engineering
Grzegorz Guzik
BACKGROUND: Metastases from malignant tumors most commonly occur in the axial skeleton (spine, ribs and pelvis). Bony metastases most often arise from breast, prostate and kidney cancer as well as myeloma, in which patient survival is relatively long. Large lytic defects within the pelvis, and especially the acetabular area, necessitate surgical treatment with specially designed prostheses, which significantly improves the patients' quality of life. The aim of the study was to determine the indications and early outcomes and describe the surgical technique of implantation of the Lumic prosthesis...
November 2015: Ortopedia, Traumatologia, Rehabilitacja
Yoshinobu Komai, Maki Sugimoto, Naoto Gotohda, Nobuaki Matsubara, Tatsushi Kobayashi, Yasuyuki Sakai, Yoshiyuki Shiga, Norio Saito
OBJECTIVE: To report our initial experience with a novel style of 3-dimensional (3D) printed kidney, which we call "4D" surgical navigation in minimally invasive off-clamp partial nephrectomy (PN). MATERIALS AND METHODS: Ten patients with a R.E.N.A.L. nephrometry score ≥8 renal mass underwent minimally invasive off-clamp PN navigated with the aid of a patient-specific 3D printed kidney. To enhance the advantage of a 3D printed organ, we herein designed our 3D printed kidneys so that the tumor and its margin could be removed...
May 2016: Urology
Jin Woo Jung, Jung-Seob Lee, Dong-Woo Cho
Recently, much attention has focused on replacement or/and enhancement of biological tissues via the use of cell-laden hydrogel scaffolds with an architecture that mimics the tissue matrix, and with the desired three-dimensional (3D) external geometry. However, mimicking the heterogeneous tissues that most organs and tissues are formed of is challenging. Although multiple-head 3D printing systems have been proposed for fabricating heterogeneous cell-laden hydrogel scaffolds, to date only the simple exterior form has been realized...
2016: Scientific Reports
Ryota Souzaki, Yoshiaki Kinoshita, Satoshi Ieiri, Naonori Kawakubo, Satoshi Obata, Takahiro Jimbo, Yuhki Koga, Makoto Hashizume, Tomoaki Taguchi
BACKGROUND: Three-dimensional (3D) printed models based on computed tomography (CT) images facilitate the visualization of complex structures and are useful for understanding the surgical anatomy preoperatively. We developed a preoperative surgical simulation method using a 3D printed model based on CT images obtained prior to laparoscopic adrenalectomy for adrenal neuroblastomas (NBs). MATERIALS AND METHODS: The multi-detector CT images were transferred to a 3D workstation, and 3D volume data were obtained by reconstructing the sections...
December 2015: Journal of Pediatric Surgery
Michael Del Junco, Renai Yoon, Zhamshid Okhunov, Garen Abedi, Christina Hwang, Benjamin Dolan, Jaime Landman
PURPOSE: We compared the flow characteristics of novel three-dimensional (3D) printed ureteral stents with four conventional double-pigtail stents in an ex vivo porcine model. MATERIALS AND METHODS: In six ex vivo porcine urinary systems with kidneys and ureters intact, we deployed a 5F occlusion catheter in an interpolar calix. We tested each system with antegrade irrigation with a 0.9% saline bag placed 35 cm above the renal pelvis. We evaluated four standard stents (6F Universa® Soft, 7F Percuflex,™ 7/10F Applied Endopyelotomy, 8...
September 2015: Journal of Endourology
Jean-Christophe Bernhard, Shuji Isotani, Toru Matsugasumi, Vinay Duddalwar, Andrew J Hung, Evren Suer, Eduard Baco, Raj Satkunasivam, Hooman Djaladat, Charles Metcalfe, Brian Hu, Kelvin Wong, Daniel Park, Mike Nguyen, Darryl Hwang, Soroush T Bazargani, Andre Luis de Castro Abreu, Monish Aron, Osamu Ukimura, Inderbir S Gill
PURPOSE: To assess the impact of 3D printed models of renal tumor on patient's understanding of their conditions. Patient understanding of their medical condition and treatment satisfaction has gained increasing attention in medicine. Novel technologies such as additive manufacturing [also termed three-dimensional (3D) printing] may play a role in patient education. METHODS: A prospective pilot study was conducted, and seven patients with a primary diagnosis of kidney tumor who were being considered for partial nephrectomy were included after informed consent...
March 2016: World Journal of Urology
Margaret Knoedler, Allison H Feibus, Andrew Lange, Michael M Maddox, Elisa Ledet, Raju Thomas, Jonathan L Silberstein
OBJECTIVE: To evaluate the effect of 3-dimensionally (3D) printed physical renal models with enhancing masses on medical trainee characterization, localization, and understanding of renal malignancy. METHODS: Proprietary software was used to import standard computed tomography (CT) cross-sectional imaging into 3D printers to create physical models of renal units with enhancing renal lesions in situ. Six different models were printed from a transparent plastic resin; the normal parenchyma was printed in a clear, translucent plastic, with a red hue delineating the suspicious renal lesion...
June 2015: Urology
Yi Zhang, Hong-wei Ge, Ning-chen Li, Cheng-fan Yu, Hong-feng Guo, Shi-hua Jin, Jin-shun Liu, Yan-qun Na
OBJECTIVES: To investigate the impact of three-dimensional (3D) printing on the surgical planning, potential of training and patients' comprehension of minimally invasive surgery for renal tumors. METHODS: Patients of a T1N0M0 single renal tumor and indicated for laparoscopic partial nephrectomy were selected. CT data were sent for post-processing and output to the 3D printer to create kidney models with tumor. By presenting to experienced laparoscopic urologists and patients, respectively, the models' realism, effectiveness for surgical planning and training, and patients' comprehension of disease and procedure were evaluated with plotted questionnaires (10-point rating scales, 1-not at all useful/not at all realistic/poor, 10-very useful/very realistic/excellent)...
April 2016: World Journal of Urology
Liliang Ouyang, Rui Yao, Xi Chen, Jie Na, Wei Sun
3D printing has evolved into a versatile technology for fabricating tissue-engineered constructs with spatially controlled cells and biomaterial distribution to allow biomimicking of in vivo tissues. In this paper, we reported a novel study of 3D printing of cell lines derived from human embryonic kidney tissue into a macroporous tissue-like construct. Nozzle temperature, chamber temperature and the composition of the matrix material were studied to achieve high cell viability (>90%) after 3D printing and construct formation...
2015: Biofabrication
Chang H Lee, Scott A Rodeo, Lisa Ann Fortier, Chuanyong Lu, Cevat Erisken, Jeremy J Mao
Regeneration of complex tissues, such as kidney, liver, and cartilage, continues to be a scientific and translational challenge. Survival of ex vivo cultured, transplanted cells in tissue grafts is among one of the key barriers. Meniscus is a complex tissue consisting of collagen fibers and proteoglycans with gradient phenotypes of fibrocartilage and functions to provide congruence of the knee joint, without which the patient is likely to develop arthritis. Endogenous stem/progenitor cells regenerated the knee meniscus upon spatially released human connective tissue growth factor (CTGF) and transforming growth factor-β3 (TGFβ3) from a three-dimensional (3D)-printed biomaterial, enabling functional knee recovery...
December 10, 2014: Science Translational Medicine
Shiqin Su, Kathryn Moran, James L Robar
This is a proof-of-concept study demonstrating the capacity for modulated electron radiation therapy (MERT) dose distributions using 3D printed bolus. Previous reports have involved bolus design using an electron pencil beam model and fabrication using a milling machine. In this study, an in-house algorithm is presented that optimizes the dose distribution with regard to dose coverage, conformity, and homogeneity within the planning target volume (PTV). The algorithm takes advantage of a commercial electron Monte Carlo dose calculation and uses the calculated result as input...
2014: Journal of Applied Clinical Medical Physics
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