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https://www.readbyqxmd.com/read/27576196/evaluation-of-feline-uterine-and-umbilical-arteries-blood-flow-in-a-pharmacologically-induced-abnormal-gestation-model
#1
P G Blanco, R Vercellini, A Rube, R Rodríguez, D O Arias, C Gobello
The aim of this study was to describe resistance index (RI) and systolic/diastolic ratio (S/D ratio) of uterine and umbilical arteries in an experimental model of abnormal pregnancy in felids. On days 30 to 35 (32 ± 2.9) after mating, 20 domestic short-hair pregnant queens were randomly assigned to one of the following treatment groups: a treated group (TG; n = 8), which received 10 mg/kg of aglepristone subcutaneously twice, 24 hours apart, and a control nontreated group (CG; n = 12). M-mode and Doppler ultrasonographic evaluations were performed at the initiation of the treatment (Day 0) and then every other day during 8 days...
August 4, 2016: Theriogenology
https://www.readbyqxmd.com/read/27533758/effects-of-digitalis-on-mortality-in-a-large-cohort-of-implantable-cardioverter-defibrillator-recipients-results-of-a-long-term-follow-up-study-in-1020-patients
#2
Julia W Erath, Mate Vamos, Stefan H Hohnloser
AIMS: The effects of digitalis on mortality in patients with structural heart disease are controversially discussed. We aimed to assess the effects of digitalis administration in implantable cardioverter defibrillator (ICD) recipients. METHODS AND RESULTS: This retrospective analysis comprises 1020 consecutive patients who received an ICD at our institution and who were followed for up to 10 years (median 37 months). A total of 438 patients were receiving digitalis at the time of ICD implantation and 582 did not...
July 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/27496489/comparison-of-mechanical-circulatory-support-by-the-use-of-pulsatile-left-ventricular-assist-devices-polvad-mev-and-continuous-flow-heart-ware-and-heart-mate-ii-in-a-single-center-experience
#3
P Nadziakiewicz, J Pacholewicz, M Zakliczynski, T Niklewski, J Borkowski, T Hrapkowicz, M Zembala
BACKGROUND: Mechanical circulatory support is increasingly used in patients with heart failure as a bridge to transplant or recovery. Results of use the Polish POLVAD MEV pulsatile circulatory support system and its comparison with novel devices never was done. We compared the course of patients with left ventricular circulatory support (left ventricular assist device [LVAD]) supported by POLVAD MEV or continuous flow devices Heart Mate II (HM II) and Heart Ware (HW) in single-center cohort...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27402911/advanced-maternal-age-causes-adverse-programming-of-mouse-blastocysts-leading-to-altered-growth-and-impaired-cardiometabolic-health-in-post-natal-life
#4
M A Velazquez, C G C Smith, N R Smyth, C Osmond, T P Fleming
STUDY QUESTION: Does advanced maternal age (AMA) in mice affect cardiometabolic health during post-natal life in offspring derived from an assisted reproduction technology (ART) procedure? SUMMARY ANSWER: Offspring derived from blastocysts collected from aged female mice displayed impaired body weight gain, blood pressure, glucose metabolism and organ allometry during post-natal life compared with offspring derived from blastocysts from young females; since all blastocysts were transferred to normalized young mothers, this effect is independent of maternal pregnancy conditions...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/27356851/mechanism-of-uncoupling-protein%C3%A2-2%C3%A2-mediated-myocardial-injury-in-hypothermic-preserved-rat-hearts
#5
Gai-Ge Chen, Jin-Bin Yan, Xu-Ming Wang, Ming-Zhi Zheng, Jian-Ping Jiang, Xin-Mei Zhou, Bin Cai, Yue-Liang Shen
In the present study, the alterations in uncoupling protein 2 (UCP2) expression following hypothermic preservation in rat hearts were investigated. Isolated rat hearts were preserved in Celsior solution for 3‑12 h followed by 60 min of reperfusion. The cardiac function was evaluated using the Langendorff perfusion system. UCP2 and silent mating type information regulation 2 homolog 1 (SIRT1) proteins were detected by western blot analysis. The ATP production and mitochondrial reactive oxygen species (ROS) levels were assessed...
August 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27208803/prevalence-and-predictors-of-metformin-prescribing-in-adults-with-type-2-diabetes-mellitus-a-national-cross-sectional-study
#6
Mate M Soric, John M Moorman, Jaclyn A Boyle, Christine M Dengler-Crish
OBJECTIVE: Metformin is the first-line oral type 2 diabetes treatment. Despite an abundance of evidence, metformin is routinely underused. This study evaluated the rates of metformin use in an appropriate outpatient type 2 diabetes population and identified predictors of metformin use. METHODS: A national cross-sectional study was conducted using data from the National Ambulatory Medical Care Survey. Office visits involving patients aged 18-79 years with a diagnosis of type 2 diabetes were included, and visits involving patients with a diagnosis of chronic renal failure or heart failure were excluded...
July 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27185937/pravastatin-ameliorates-placental-vascular-defects-fetal-growth-and-cardiac-function-in-a-model-of-glucocorticoid-excess
#7
Caitlin S Wyrwoll, June Noble, Adrian Thomson, Dijana Tesic, Mark R Miller, Eva A Rog-Zielinska, Carmel M Moran, Jonathan R Seckl, Karen E Chapman, Megan C Holmes
Fetoplacental glucocorticoid overexposure is a significant mechanism underlying fetal growth restriction and the programming of adverse health outcomes in the adult. Placental glucocorticoid inactivation by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) plays a key role. We previously discovered that Hsd11b2(-/-) mice, lacking 11β-HSD2, show marked underdevelopment of the placental vasculature. We now explore the consequences for fetal cardiovascular development and whether this is reversible. We studied Hsd11b2(+/+), Hsd11b2(+/-), and Hsd11b2(-/-) littermates from heterozygous (Hsd11b(+/-)) matings at embryonic day (E)14...
May 31, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27093953/knockout-of-the-prostaglandin-e2-receptor-subtype-3-promotes-eccentric-cardiac-hypertrophy-and-fibrosis-in-mice
#8
Shuang Liu, Yawei Ji, Jian Yao, Xiaodan Zhao, Hu Xu, Youfei Guan, Richard M Breyer, Hongzhuan Sheng, Jianhua Zhu
BACKGROUND: Prostaglandin E2 receptor subtype 3 (EP3), a Gi protein-coupled receptor activated by prostaglandin E2, plays a particular role in cardioprotection. This study aimed to investigate the impact of EP3 deletion on cardiac remodeling and further elucidate the related involvement of possible signaling pathways. METHODS AND RESULTS: The animals used were EP3 receptor knockout (EP3KO) mice and wild-type (WT) litter mate controls at 16-18 weeks old. The high-resolution echocardiography and weight index indicated that eccentric cardiac hypertrophy might occur in EP3KO mice, which were having worse cardiac function than WT litter mates...
April 18, 2016: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27090167/complete-antegrade-transapical-deployment-of-a-branched-aortic-arch-endograft-a-porcine-feasibility-study
#9
Sabine Wipper, Christina Lohrenz, Jan F Kersten, Mohamad Marwan Akkra, Nikos Tsilimparis, Christian Detter, Yskert von Kodolitsch, Axel Larena-Avellaneda, Eike Sebastian Debus, Tilo Kölbel
PURPOSE: To describe and prove the concept of a technique for complete transapical deployment of a single-branch aortic arch endograft in a porcine model. METHODS: Eight domestic pigs underwent antegrade transapical delivery of a single-branch arch endograft, including a mating stent-graft to the innominate artery. Technical feasibility, operating time, radiation parameters, and hemodynamic changes were studied according to a standardized protocol during baseline (T0), after establishing the transapical access and through-and-through wire (T1), and after stent-graft deployment (T2)...
June 2016: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/27086670/new-treatment-for-percutaneous-sites-in-patients-with-a-ventricular-assist-device-nihon-university-crystal-violet-method
#10
Akira Sezai, Tetsuya Niino, Shunji Osaka, Hiroko Yaoita, Munehito Arimoto, Hiroaki Hata, Motomi Shiono
BACKGROUND: Infection of the percutaneous site of a ventricular assist device (VAD) is a challenging complication. We report our experience with crystal violet Solbase (Nihon University crystal violet method) for prevention of driveline or cannula infections in VAD patients. PATIENTS AND METHODS: The crystal violet method was used in 10 patients (prophylaxis in nine and treatment in one). Eight patients had an extracorporeal VAD (Nipro) and two had an implantable VAD (Heart Mate II)...
August 23, 2016: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27065125/heart-rate-patterns-during-courtship-and-mating-in-rams-and-in-estrous-and-nonestrous-ewes
#11
A Orihuela, J C Omaña, R Ungerfeld
The aim of this study was to compare the heart rate (HR) patterns in rams mated with estrous or nonestrous ewes and in mated estrous and nonestrous ewes () during courtship and mating. For this purpose, HR and behavior were recorded using a radio telemetry recording system and a closed-circuit television system with video recording, respectively. Rams were joined with either an estrous ( = 10) or a nonestrous ( = 10) ewe that was restrained in a stanchion by the neck. Data were continuously recorded until each ram performed 3 ejaculations...
February 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27038779/type-2-diabetes-mellitus-induces-congenital-heart-defects-in-murine-embryos-by-increasing-oxidative-stress-endoplasmic-reticulum-stress-and-apoptosis
#12
Yanqing Wu, E Albert Reece, Jianxiang Zhong, Daoyin Dong, Wei-Bin Shen, Christopher R Harman, Peixin Yang
BACKGROUND: Maternal type 1 and 2 diabetes mellitus are strongly associated with high rates of severe structural birth defects, including congenital heart defects. Studies in type 1 diabetic embryopathy animal models have demonstrated that cellular stress-induced apoptosis mediates the teratogenicity of maternal diabetes leading to congenital heart defect formation. However, the mechanisms underlying maternal type 2 diabetes mellitus-induced congenital heart defects remain largely unknown...
September 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26987204/-study-on-congenital-cardiac-anomalies-induced-by-arsenic-exposure-before-and-during-maternal-pregnancy-in-fetal-rats
#13
Yuan Lin, Lingzi Zhuang, Hong Ma, Lixiang Wu, Hailong Huang, Huanhuan Guo
OBJECTIVE: To investigate the effects of arsenic exposure before and during maternal pregnancy on heart development of fetal rats. METHODS: According to body weight, thirty-two female SD rats (30 to 40 days of age) were randomly divided into control group, low dose group, middle dose group and high dose group with 8 rats per group. They were allowed free access to drinking water with 0, 37.5, 75 and 150 mg/L of sodium arsenite (NaAsO2) for 6 weeks, respectively...
January 2016: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/26721914/antiplatelet-therapy-and-adverse-hematologic-events-during-heart-mate-ii-support
#14
COMPARATIVE STUDY
Omar Saeed, Aman Shah, Faraj Kargoli, Shivank Madan, Allison P Levin, Snehal R Patel, Rita Jermyn, Cesar Guerrero, Jenni Nguyen, Daniel B Sims, Julia Shin, David D'Alessandro, Daniel J Goldstein, Ulrich P Jorde
BACKGROUND: Hematologic adverse events are common during continuous flow left ventricular assist device support; yet, their relation to antiplatelet therapy, including aspirin (ASA) dosing, is uncertain. METHODS AND RESULTS: A single-center retrospective review of all patients supported by a continuous flow left ventricular assist device (Heart Mate II) from June 2006 to November 2014 was conducted. Patients were categorized into 3 groups: (1) ASA 81 mg+dipyridamole 75 mg daily (n = 26) with a target international normalized ratio (INR) of 2 to 3 from June 2006 to August 2009; (2) ASA 81 mg daily (n = 18) from September 2009 to August 2011 with a target INR of 1...
January 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/26701316/the-opportunity-for-post-copulatory-sexual-selection-in-the-ectoparasitic-pea-crab-dissodactylus-primitivus-brachyura-pinnotheridae
#15
Robert B Prather, Stephen M Shuster
Pea crabs, Dissodactylus primitivus, inhabit multiple echinoid (heart urchin) hosts. Male and female crabs move among hosts in search for mates, and both sexes mate multiple times, creating opportunities for post-copulatory sexual selection. For such selection to occur, only a fraction of the males who succeed in mating can also succeed in siring progeny. Jossart et al. 2014 used 4 microsatellite loci to document parentage and mating frequencies of both sexes in D. primitivus. From these data we identified the mean and variance in female offspring numbers, as well as the proportions of the female population that were gravid and not bearing offspring...
2015: PloS One
https://www.readbyqxmd.com/read/26661577/effect-of-an-ilex-paraguariensis-yerba-mate-extract-on-infarct-size-in-isolated-rat-hearts-the-mechanisms-involved
#16
Luisa F González Arbeláez, Juliana C Fantinelli, Alejandro Ciocci Pardo, Claudia I Caldiz, José Luis Ríos, Guillermo R Schinella, Susana M Mosca
Tea made from Ilex paraguariensis (IP) dried and minced leaves is a beverage widely consumed by large populations in South America as a source of caffeine (stimulant action) and for its medicinal properties. However, there is little information about the action of IP on the myocardium in the ischemia-reperfusion condition. Therefore, the objective of this study was to examine the effects of an aqueous extract of IP on infarct size in a model of regional ischemia. Isolated rat hearts were perfused by the Langendorff technique and subjected to 40 min of coronary artery occlusion followed by 60 min of reperfusion (ischemic control hearts)...
February 2016: Food & Function
https://www.readbyqxmd.com/read/26609873/atrioventricular-valvular-anomalies-and-their-role-in-the-etiopathogenesis-of-cardiorespiratory-syndrome-in-farmed-common-foxes-vulpes-vulpes
#17
Agnieszka Noszczyk-Nowak, Tomasz Piasecki, Alicja Cepiel, Marcin Nowak, Izabela Janus, Urszula Pasławska
BACKGROUND: Cardiorespiratory syndrome of common foxes is associated with a mortality rate ranging from 2.1% to 20%. OBJECTIVE: The aim of this study was to analyze the prevalence of cardiac abnormalities in common foxes (Vulpes vulpes) from Polish farms with a history of cardiorespiratory syndrome. ANIMALS AND METHODS: The prevalence of cardiac abnormalities in common foxes from a Polish farm with a history of cardiorespiratory syndrome was assessed as well as morphological examination of 60 heart specimens from clinically healthy animals...
2016: Veterinary Quarterly
https://www.readbyqxmd.com/read/26581635/inflammatory-and-fibrotic-processes-are-involved-in-the-cardiotoxic-effect-of-sunitinib-protective-role-of-l-carnitine
#18
Antonio J Blanca, María V Ruiz-Armenta, Sonia Zambrano, José L Miguel-Carrasco, José L Arias, Miguel Arévalo, Alfonso Mate, Oscar Aramburu, Carmen M Vázquez
Sunitinib (Su) is currently approved for treatment of several malignances. However, along with the benefits of disease stabilization, cardiovascular toxicities have also been increasingly recognized. The aim of this study was to analyze which mechanisms are involved in the cardiotoxicity caused by Su, as well as to explore the potential cardioprotective effects of l-carnitine (LC). To this end, four groups of Wistar rats were used: (1) control; (2) rats treated with 400mg LC/kg/day; (3) rats treated with 25mg Su/kg/day; and (4) rats treated with LC+Su simultaneously...
January 22, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/26566220/effects-of-high-intensity-interval-training-on-pregnant-rats-and-the-placenta-heart-and-liver-of-their-fetuses
#19
Nils Thomas Songstad, Knut-Helge Frostmo Kaspersen, Anne Dragøy Hafstad, Purusotam Basnet, Kirsti Ytrehus, Ganesh Acharya
OBJECTIVE: To investigate the effects of high intensity interval training (HIIT) on the maternal heart, fetuses and placentas of pregnant rats. METHODS: Female Sprague-Dawley rats were randomly assigned to HIIT or sedentary control groups. The HIIT group was trained for 6 weeks with 10 bouts of high intensity uphill running on a treadmill for four minutes (at 85-90% of maximal oxygen consumption) for five days/week. After three weeks of HIIT, rats were mated. After six weeks (gestational day 20 in pregnant rats), echocardiography was performed to evaluate maternal cardiac function...
2015: PloS One
https://www.readbyqxmd.com/read/26530934/effects-of-high-fat-feeding-on-ectopic-fat-storage-and-postprandial-lipid-metabolism-in-mouse-offspring
#20
Petronella A van Ewijk, Sabina Paglialunga, M Eline Kooi, Patricia M Nunes, Anne Gemmink, Jos Slenter, Esther Kornips, Johanna A Jörgensen, Joris Hoeks, Joachim E Wildberger, Matthijs K C Hesselink, Jan F C Glatz, Arend Heerschap, Sander Kersten, Patrick Schrauwen, Vera B Schrauwen-Hinderling
OBJECTIVE: Parental high-fat feeding was proposed to negatively impact metabolic health in offspring. Here, the ectopic fat storage in heart and liver in offspring was investigated, and the effects on mitochondrial function, de novo lipogenesis, and postprandial lipid metabolism were explored in detail. METHODS: Male and female mice received either a high-fat (HF) or standard chow (LF) diet during mating, gestation and lactation. All offspring animals received the HF diet...
November 2015: Obesity
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