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Hip maturity

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https://www.readbyqxmd.com/read/29128864/association-of-%C3%AE-2-hs-glycoprotein-with-neurogenic-heterotopic-ossification-in-patients-with-spinal-cord-injury
#1
Liwei Dong, Guodong Dong, Jianye Cao, Jing Zhang
BACKGROUND The aim of this study was to explore the relationship between the α2-HS glycoprotein concentrations in serum and the occurrence of neurogenic heterotopic ossification (NHO) in patients with spinal cord injury (SCI). MATERIAL AND METHODS During the period between January 2011 and January 2012, 75 patients (67 male) with paraplegia caused by spinal cord injury were enrolled. The patients were divided into 2 groups in accordance with the occurrence of heterotopic ossification based on the results high-frequency ultrasound on the bilateral hip joint...
November 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29080986/use-of-the-t%C3%A3-bingen-splint-for-the-initial-management-of-severely-dysplastic-and-unstable-hips-in-newborns-with-ddh-an-alternative-to-fettweis-plaster-and-pavlik-harness
#2
Hannes Kubo, Hakan Pilge, Kristina Weimann-Stahlschmidt, Karoline Stefanovska, Bettina Westhoff, Ruediger Krauspe
AIM: Hip dysplasia is one of the most common skeletal disorders. As a late consequence 20-25% of the patients are at risk to develop secondary osteoarthritis and may require total hip replacement early in life. The treatment principles of hip dislocation are (1) concentric reposition, (2) retention, i.e., plaster in human post or Pavlik harness and (3) maturation in abduction flexion orthesis. The Tübingen splint was introduced as a further development of abduction devices for the treatment of (residual) hip dysplasia with stable hips...
October 28, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29076029/bariatric-surgery-registries-can-they-contribute-to-improved-outcomes
#3
REVIEW
Wendy A Brown, Andrew D MacCormick, John J McNeil, Ian D Caterson
PURPOSE OF REVIEW: Clinical registries systematically collect prospective information about patients with a particular medical condition, who have had a medical device implanted or who have undergone a particular procedure. When these variables are collected with pre-defined quality indices included, the benched-marked risk-adjusted data may be a valuable resource for providing feedback on outcomes, including performance, to practitioners, patients, health services and device manufacturers...
October 26, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/29038743/mature-induced-pluripotent-stem-cell-derived-human-podocytes-reconstitute-kidney-glomerular-capillary-wall-function-on-a-chip
#4
Samira Musah, Akiko Mammoto, Thomas C Ferrante, Sauveur S F Jeanty, Mariko Hirano-Kobayashi, Tadanori Mammoto, Kristen Roberts, Seyoon Chung, Richard Novak, Miles Ingram, Tohid Fatanat-Didar, Sandeep Koshy, James C Weaver, George M Church, Donald E Ingber
An in vitro model of the human kidney glomerulus - the major site of blood filtration - could facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a-chip technology has been used to model the human proximal tubule, yet a kidney-glomerulus-on-a-chip has not been possible because of the lack of functional human podocytes - the cells that regulate selective permeability in the glomerulus. Here, we demonstrate an efficient (> 90%) and chemically defined method for directing the differentiation of human induced pluripotent stem (hiPS) cells into podocytes that express markers of the mature phenotype (nephrin+, WT1+, podocin+, Pax2-) and that exhibit primary and secondary foot processes...
2017: Nature biomedical engineering
https://www.readbyqxmd.com/read/28972793/potential-discrepancy-between-plain-films-and-ct-scans-in-brooker-classification-of-heterotopic-ossification
#5
Tao Mary Jiayi, Probyn Linda, Poon Michael, Kreder Hans, Nousiainen Markku, Jenkinson Richard, Wan Bo Angela, Tsao May, Barnes Elizabeth, Chow Edward
OBJECTIVES: The Brooker classification is a commonly used tool to characterize the extent of heterotopic ossification (HTO), which is the dystrophic formation of mature lamellar bone in non-osseous tissues such as muscles, connective tissue or nerves. We aim to provide illustrative cases to describe the limitations and challenges of this system. METHODS: A retrospective review was conducted in all patients who had retrieved hip and/or pelvic radiotherapy for HTO prophylaxis at Sunnybrook Health Sciences Centre between July 1998 and August 2016...
December 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28963460/hedgehog-interacting-protein-hip-regulates-apoptosis-evasion-and-angiogenic-function-of-late-endothelial-progenitor-cells
#6
Bom Nae Rin Lee, Yeon Sung Son, Dabin Lee, Young-Jin Choi, Sang-Mo Kwon, Hyun-Kyung Chang, Pyung-Hwan Kim, Je-Yoel Cho
Late endothelial progenitor cells (LEPCs) are derived from mononuclear cells (MNCs) and are thought to directly incorporate into blood vessels and differentiate into mature endothelial cells (ECs). Using transcriptome and proteome analysis, we identified distinctive LEPC profiles and found that Hedgehog-interacting protein (HIP) is strongly expressed in LEPCs. Inhibition of HIP by lentiviral knockdown activated canonical hedgehog signaling in LEPCs, while it activated non-canonical hedgehog signaling in ECs...
September 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28828063/analysis-of-pelvic-fracture-pattern-and-overall-orthopaedic-injury-burden-in-children-sustaining-pelvic-fractures-based-on-skeletal-maturity
#7
M K Shaath, K L Koury, P D Gibson, V M Lelkes, J S Hwang, J A Ippolito, M R Adams, M S Sirkin, M C Reilly
PURPOSE: The purpose of this study was to review pelvic fractures and concomitant orthopaedic injuries in children who have a patent triradiate cartilage (TRO) compared with children whose triradiate cartilage has closed (TRC). We hypothesise that these injuries will differ, leading to correlated alterations in management. PATIENTS AND METHODS: Using a database, we retrospectively reviewed patients aged below 18 years with pelvic fractures presenting to our Level 1 trauma center...
June 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28815554/severe-disruption-and-disorganization-of-dermal-collagen-fibrils-in-early-striae-gravidarum
#8
F Wang, K Calderone, T T Do, N R Smith, Y R Helfrich, T R B Johnson, S Kang, J J Voorhees, G J Fisher
BACKGROUND: Striae gravidarum (SG), or stretch marks of pregnancy, begin as erythematous streaks, and mature into hypopigmented atrophic bands. OBJECTIVES: To investigate molecular alterations that may promote atrophy of SG, we investigated dermal type I collagen fibrils, which provide human skin with support. METHODS: We obtained skin samples of recently developed, erythematous abdominal SG from pregnant women. To examine the organization of collagen fibrils, second-harmonic generation imaging was performed using multiphoton microscopy...
August 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28767613/effect-of-greater-trochanteric-epiphysiodesis-after-femoral-varus-osteotomy-for-lateral-pillar-classification-b-and-b-c-border-legg-calv%C3%A3-perthes-disease-a-retrospective-observational-study
#9
Keun-Sang Kwon, Sung Il Wang, Ju-Hyung Lee, Young Jae Moon, Jung Ryul Kim
This is a retrospective observational study. Greater trochanteric epiphysiodesis (GTE) has been recommended to prevent Trendelenburg gait and limitation of the hip joint motion due to trochanteric overgrowth after femoral varus osteotomy (FVO) in Legg-Calvé-Perthes disease (LCPD). However, capital femoral physeal arrest frequently occurs in patients with severe disease (lateral pillar C), so GTE might not be as effective in these patients. The aim of this study was to compare trochanteric growth inhibition due to GTE after FVO between 2 age groups (<8 or >8 years) in patients with lateral pillar B and B/C border LCPD and evaluate the effectiveness of GTE compared with the normal, unaffected hip...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723877/human-spinal-bone-dust-as-a-potential-local-autograft-in-vitro-potent-anabolic-effect-on-human-osteoblasts
#10
Ryan Gao, Matthew Street, Mei Lin Tay, Karen E Callon, Dorit Naot, Alistair Lock, Jacob T Munro, Jillian Cornish, John Ferguson, David Musson
STUDY DESIGN: In Vitro Study. OBJECTIVE: To evaluate the effect that factors released from human posterior spinal bone dust have on primary human osteoblast growth and maturation. SUMMARY OF BACKGROUND DATA: Bone dust, created during spinal fusion surgeries has the potential to be used as an autologous bone graft by providing a source of viable autologous osteoblasts and mesenchymal stem cells with osteogenic potential. To date, no information is available on whether bone dust also provides a source of anabolic factors with the potential to enhance osteoblast proliferation and maturation, which would enhance its therapeutic potential...
July 18, 2017: Spine
https://www.readbyqxmd.com/read/28717864/diagnosing-developmental-dysplasia-of-the-hip-using-the-graf-ultrasound-method-risk-and-protective-factor-analysis-in-11-820-universally-screened-newborns
#11
Mohammad Schams, Rob Labruyère, Anne Zuse, Mikolaj Walensi
The essential role of ultrasound examinations in diagnosis and treatment of developmental dysplasia of the hip (DDH) is widely accepted while the weighting and correlation of protective factors and perinatal risk for DDH still give rise to debate. Our aim was to investigate the impact of single and twofold combined risk and protective factors on the newborns' hip maturity, assessed with the Graf ultrasound method. Therefore, data sets of 11,820 universally screened newborns were analyzed. Univariate and logistic regression analyses were performed to correlate risk and protective factors with mature or immature but appropriate for age and pathologic hip types...
September 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28717411/skeletal-muscle-generated-from-induced-pluripotent-stem-cells-induction-and-application
#12
REVIEW
Yuko Miyagoe-Suzuki, Shin'ichi Takeda
Human induced pluripotent stem cells (hiPS cells or hiPSCs) can be derived from cells of patients with severe muscle disease. If skeletal muscle induced from patient-iPSCs shows disease-specific phenotypes, it can be useful for studying the disease pathogenesis and for drug development. On the other hand, human iPSCs from healthy donors or hereditary muscle disease-iPSCs whose genomes are edited to express normal protein are expected to be a cell source for cell therapy. Several protocols for the derivation of skeletal muscle from human iPSCs have been reported to allow the development of efficient treatments for devastating muscle diseases...
June 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28661717/structural-strength-benefits-observed-at-the-hip-of-premenarcheal-gymnasts-are-maintained-into-young-adulthood-10-years-after-retirement-from-the-sport
#13
Marta C Erlandson, Shonah B Runalls, Stefan A Jackowski, Robert A Faulkner, Adam D G Baxter-Jones
PURPOSE: Premenarcheal female gymnasts have been consistently found to have greater bone mass and structural advantages. However, little is known about whether these structural advantages are maintained after the loading stimulus is removed. Therefore, the purpose of this study was to investigate the structural properties at the hip after long-term retirement from gymnastics. METHODS: Structural properties were derived from dual-energy X-ray absorptiometry scans using the hip structural analysis program for the same 24 gymnasts and 21 nongymnasts both in adolescence (8-15 y) and adulthood (22-30 y)...
November 1, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28661042/cd11b-promotes-the-differentiation-of-osteoclasts-induced-by-rankl-through-the-spleen-tyrosine-kinase-signalling-pathway
#14
Guoxi Yang, Xiaoyong Chen, Zhao Yan, Qingsheng Zhu, Chongfei Yang
Macrophage surface antigen-1 (Mac-1, CD11b/CD18) has been implicated in the regulation of osteoclastogenesis. In the synovial tissues of patients with aseptic loosening after total hip replacement, CD11b was up-regulated, which indicated that CD11b is closely involved in osteolysis around the prosthesis. We found that CD11b, but not CD18, promoted osteoclast (OC) maturation. Here, we show CD11b up-regulated the levels of spleen tyrosine kinase (Syk), c-Fos and nuclear factor of activated T cells, cytoplasmic-1 (NFATc1), as well as the activity of extracellular-regulated kinase (Erk), and as a result, osteoclast precursors (OCPs) differentiated and became tartrate-resistant acid phosphatase (TRAP)-positive...
June 29, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28630724/labral-reconstruction-with-tendon-allograft-histological-findings-show-revascularization-at-8-weeks-from-implantation
#15
Esther Moya Gómez, Carlomagno Cardenas, Emmanuelle Astarita, Vittorio Bellotti, Francesc Tresserra, Luis Gerardo Natera, Manel Ribas
This description shows the histological findings of a peroneus brevis tendon allograft used for labral reconstruction, implanted 8 weeks before being retrieved due to a postoperative complication unrelated to the graft. As far as we have knowledge this is the first description about revascularization of an allograft used for hip labral reconstruction. The histological report of the removed peroneus brevis tendon allograft shows evidence of vascular ingrowth represented by small vessels with a thin muscular wall in all layers of the graft and cellular migration mainly represented by mature fibroblasts...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28612306/bone-density-and-body-composition-in-newly-licenced-professional-jockeys
#16
K A Jackson, M T Sanchez-Santos, A L MacKinnon, A Turner, K Kuznik, S Ellis, C Box, J Hill, M K Javaid, C Cooper, N K Arden, J L Newton
The primary objective is the description of bone mineral density (BMD) and body composition in newly licensed jockeys. One in three male, flat jockeys has a very low bone mineral density. Further research is needed to assess the short-term risk of fractures and long-term health implications of these findings. INTRODUCTION: Describe bone mineral density (BMD) and body composition in entry-level male and female, flat and jump jockeys in Great Britain. METHODS: Data was collected on jockeys applying for a professional jockey license between 2013 and 2015...
June 13, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28576270/conservative-management-of-hip-dysplasia
#17
REVIEW
Tisha A M Harper
Hip dysplasia (HD) is a common orthopedic condition seen in small animal patients that leads to osteoarthritis of the coxofemoral joint. The disease can be managed conservatively or surgically. The goals of surgical treatment in the immature patient are to either prevent the clinical signs of HD or to prevent or slow the progression of osteoarthritis. In mature patients surgery is used as a salvage procedure to treat debilitating osteoarthritis. Conservative management can be used in dogs with mild or intermittent clinical signs and includes nutritional management and weight control, exercise modification, physical rehabilitation, pain management and disease-modifying agents...
July 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28525408/rebound-deformity-after-growth-modulation-in-patients-with-coronal-plane-angular-deformities-about-the-knee-who-gets-it-and-how-much
#18
Lise A Leveille, Ozan Razi, Charles E Johnston
BACKGROUND: With observed success and increased popularity of growth modulation techniques, there has been a trend toward use in progressively younger patients. Younger age at growth modulation increases the likelihood of complete deformity correction and need for implant removal before skeletal maturity introducing the risk of rebound deformity. The purpose of this study was to quantify magnitude and identify risk factors for rebound deformity after growth modulation. METHODS: We performed a retrospective review of all patients undergoing growth modulation with a tension band plate for coronal plane deformity about the knee with subsequent implant removal...
May 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28479005/-risk-of-developmental-dysplasia-of-the-hip-in-patients-subjected-to-the-external-cephalic-version
#19
Nerea Sarmiento Carrera, Eva González Colmenero, José Luis Vázquez Castelo, Ana Concheiro Guisán, Emilio Couceiro Naveira, José Ramón Fernández Lorenzo
INTRODUCTION: Developmental dysplasia of the hip (DDH) refers to the spectrum of abnormalities of maturation and development of the hip. Breech presentation is associated with DDH. This risk factor can be modified by external cephalic version (ECV). The aim of this study is to evaluate the incidence of DDH in patients who successfully underwent ECV, as well as to evaluate need for these children (breech for a period during gestation) to be included in the DDH screening protocol. MATERIAL AND METHODS: A prospective cohort study was conducted in the Hospital Universitario de Vigo from January 1, 2015 to December 31, 2015...
May 3, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28473651/how-well-are-we-managing-fragility-hip-fractures-a-narrative-report-on-the-review-with-the-attempt-to-setup-a-fragility-fracture-registry-in-hong-kong
#20
K S Leung, W F Yuen, W K Ngai, C Y Lam, T W Lau, K B Lee, K M Siu, N Tang, S H Wong, W H Cheung
INTRODUCTION: In setting up a disease registry for fragility fractures in Hong Kong, we conducted a retrospective systematic study on the management of fragility hip fractures. Patient outcomes were compared with the standards from our orthopaedic working group and those from the British Orthopaedic Association that runs a mature fracture registry in the United Kingdom. METHODS: Clinical data on fragility hip fracture patients admitted to six acute major hospitals in Hong Kong in 2012 were captured...
May 5, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
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