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Hip maturity

Jillian Lye, Stephanie Parkinson, Nicola Diamond, Jenny Downs, Susan Morris
The strategy used to generate power for forward propulsion in walking and running has recently been highlighted as a marker of gait maturation and elastic energy recycling. This study investigated ankle and hip power generation as a propulsion strategy (PS) during the late stance/early swing phases of walking and running in typically developing (TD) children (15: six to nine years; 17: nine to 13years) using three-dimensional gait analysis. Peak ankle power generation at push-off (peakA2), peak hip power generation in early swing (peakH3) and propulsion strategy (PS) [peakA2/(peakA2+peakH3)] were calculated to provide the relative contribution of ankle power to total propulsion...
October 17, 2016: Human Movement Science
Simona Gurzu, Sabin Gligore Turdean, Sorin Tudor Pop, Ancuta Zazgyva, Ciprian Oliviu Roman, Mihaela Opris, Ioan Jung
PURPOSE: To present a hypothesis regarding the pathways of angiogenesis in primary versus secondary hip osteoarthritis (OA). METHODS: In synovial tissue samples provided by 57 consecutive patients who underwent hip arthroplasty, immunohistochemical examinations were performed using the following angiogenesis-related antibodies: VEGF-A, COX-2, maspin and the endothelial cells markers CD31 and CD105. The cases were divided into three categories: classic primary hip OA (group A; n = 16), rapidly destructive hip OA (group B; n = 24) and hip OA secondary to avascular osteonecrosis of the femoral head (group C; n = 17)...
October 4, 2016: International Orthopaedics
Aniss Chagou, Abdelatif Benbouha, Abdelkarim Rhanim, Abdou Lahlou, Mohammed Saleh Berrada, Moradh El Yaacoubi
Coxalgia causes osteocartilaginous destructions of the hip joint; these lesions are responsible for severe pain leading to functional discomfort and limitations in everyday life. Their surgical treatment is still not well established. The aim of our study was to demonstrate the interest of total hip arthroplasty associated with anti-tuberculous chemotherapy to improve patients' quality of life. We report a retrospective study of 10 cases of total hip replacement following coxalgia at the Department of Orthopaedics and Trauma of Rabat University Hospital from 2002 to 2011...
2016: Pan African Medical Journal
Anh-Dung Nguyena, Emma F Zuka, Andrea L Baellowa, Kate R Pfileb, Lindsay J DiStefanoc, Michelle C Bolingd
CONTEXT: Risk of ACL injuries in young female athletes increases with age, appearing to peak during maturation. Changes in hip muscle strength and range of motion (ROM) during this time may contribute to altered dynamic movement patterns that are known to increase risk of ACL injuries. Understanding the longitudinal changes in hip strength and ROM is needed in order to develop appropriate interventions to reduce the risk of ACL injuries. OBJECTIVE: To examine the longitudinal changes in hip strength and ROM in female youth soccer players...
August 24, 2016: Journal of Sport Rehabilitation
Christoph E Albers, Andrea Schwarz, Markus S Hanke, Karl-Philipp Kienle, Stefan Werlen, Klaus A Siebenrock
BACKGROUND: Although the etiology of primary femoroacetabular impingement (FAI) is considered developmental, the underlying pathogenic mechanisms remain poorly understood. In particular, research identifying etiologic factors associated with pincer FAI is limited. Knowledge of the physiologic growth patterns of the acetabulum during skeletal maturation might allow conclusions on deviations from normal development that could contribute to pincer-related pathomorphologies. QUESTIONS/PURPOSES: In a population of healthy children, we asked if there were any differences related to skeletal maturation with regard to (1) acetabular version; (2) acetabular depth/width ratio; and (3) femoral head coverage in the same children as assessed by MRIs obtained 1 year apart...
September 1, 2016: Clinical Orthopaedics and related Research
Araceli Espinosa-Jeffrey, Bruno Blanchi, Juan Carlos Biancotti, Shalini Kumar, Megumi Hirose, Berhan Mandefro, Dodanim Talavera-Adame, Nissim Benvenisty, Jean de Vellis
Here we document three highly reproducible protocols: (1) a culture system for the derivation of human oligodendrocytes (OLs) from human induced pluripotent stem cells (hiPS) and their further maturation-our protocol generates viral- and integration-free OLs that efficiently commit and move forward in the OL lineage, recapitulating all the steps known to occur during in vivo development; (2) a method for the isolation, propagation and maintenance of neural stem cells (NSCs); and (3) a protocol for the production, isolation, and maintenance of OLs from perinatal rodent and human brain-derived NSCs...
2016: Current Protocols in Stem Cell Biology
Ming-Yue Xiong, Li-Qiang Liu, Shi-Qiong Liu, Zhen-Hui Liu, Hang-Fei Gao
Avascular necrosis of femoral head (AVFH) is a clinically recalcitrant disease of hip that leads to joint destruction. Osteoprotegerin (OPG), receptor activator of nuclear factor kappa-B (RANK) and RANK ligand (RANKL) regulates the balance, maturation and function of osteoclast and bone remodeling. This study aims to investigate molecular pathways which leads to AVN by studying expression profile of OPG, RANK and RANKL genes. Quantitative Real Time-PCR is used to evaluate mRNA expression of OPG, RANK and RANKL...
2016: American Journal of Translational Research
T M Hill, J D Quigley, H G Bateman, F X Suarez-Mena, T S Dennis, R L Schlotterbeck
Calves fed >0.7kg of dry matter from milk replacer (MR) typically have greater growth preweaning but lower growth postweaning. This is partially explained by lower digestibility of starter due to less development of the rumen at and after weaning; however, it is unclear when digestibility matures postweaning to levels typical of mature ruminants. Thus, we fed Holstein calves (initially 2 to 3d of age) 3 MR programs (MOD=0.66kg daily for 39d, and then 0.33kg daily for 3d, n=15 calves; HIMOD=0.88kg daily for 5d, then 1...
October 2016: Journal of Dairy Science
D L Van De Stroet, J A Calderón Díaz, K J Stalder, A J Heinrichs, C D Dechow
The objective of this study was to understand the associations of calf growth traits with subsequent milk yield and body weight (BW). Data were collected for 281 Holstein heifer calves from 6 different calf trials of varying lengths (4 to 8 wk) conducted at Pennsylvania State University between 2003 and 2010. Calves were classified as high, medium, or low for hip height, starter feed intake, BW, and growth rate. Milk yield and cow BW were recorded during subsequent lactations. In total, there were 169,734 daily milk records and 136,153 cow BW records available...
October 2016: Journal of Dairy Science
Anh-Dung Nguyen, Emma F Zuk, Andrea L Baellow, Kate R Pfile, Lindsay J DiStefano, Michelle C Boling
CONTEXT: Risk of ACL injuries in young female athletes increases with age, appearing to peak during maturation. Changes in hip muscle strength and range of motion (ROM) during this time may contribute to altered dynamic movement patterns that are known to increase risk of ACL injuries. Understanding the longitudinal changes in hip strength and ROM is needed in order to develop appropriate interventions to reduce the risk of ACL injuries. OBJECTIVE: To examine the longitudinal changes in hip strength and ROM in female youth soccer players...
July 21, 2016: Journal of Sport Rehabilitation
John P Wilson, D Cary Woodruff, Jacob D Gardner, Holley M Flora, John R Horner, Chris L Organ
Rugose projections on the anterior and posterior aspects of vertebral neural spines appear throughout Amniota and result from the mineralization of the supraspinous and interspinous ligaments via metaplasia, the process of permanent tissue-type transformation. In mammals, this metaplasia is generally pathological or stress induced, but is a normal part of development in some clades of birds. Such structures, though phylogenetically sporadic, appear throughout the fossil record of non-avian theropod dinosaurs, yet their physiological and adaptive significance has remained unexamined...
2016: PloS One
Yunus Oc, Muhammed Sefa Ozcan, Hasan Basri Sezer, Bekir Eray Kilinc, Osman Tugrul Eren
In most of the cases trauma is the leading etiology and the nontraumatic myositis ossificans (MO) is a very rare condition. We present an MO case without any trauma occurring. A 36-year-old female patient with a history of pain and restriction of range of motion of the left hip was admitted. Hip motions were restricted with 10-60° of flexion, 10° of internal rotation, 20° of external rotation, 10° of abduction, and 10° of adduction. There was no history of trauma and familial involvement. The biopsy of the lesion revealed mature bone tissue confirming our diagnosis of MO...
2016: Case Reports in Orthopedics
Risa Kagan, Barry S Komm, Kelly A Ryan, Joanne Lavenberg, Ching-Ray Yu, JoAnn V Pinkerton
OBJECTIVE: The aim of the study was to determine the time course of effect with conjugated estrogens/bazedoxifene (CE/BZA) in nonhysterectomized postmenopausal women in five phase 3 trials. METHODS: This post hoc analysis identified when CE 0.45 mg/BZA 20 mg and CE 0.625 mg/BZA 20 mg first achieved a statistically significant difference (P < 0.05) versus placebo in individual trials and the duration the difference persisted for prespecified efficacy endpoints...
July 18, 2016: Menopause: the Journal of the North American Menopause Society
Yinxiu Ding, Zixin Zhang, Jiangbo Ma, Hechun Xia, Yin Wang, Yinming Liu, Quanrui Ma, Tao Sun, Juan Liu
Parkinson's disease (PD) is a severe neurodegenerative disorder. Although the detailed underlying molecular mechanism remains to be elucidated, the major pathological feature of PD is the loss of dopaminergic (DA) neurons of the substantia nigra. The use of donor stem cells to replace DA neurons may be a key breakthrough in the treatment of PD. In the present study, the growth kinetics of hippocampal neural stem cells (Hip‑NSCs) isolated from postnatal mice and cultured in vitro were observed, specifically the generation of cells expressing DA neuronal markers nuclear receptor related‑1 protein (Nurr1) and tyrosine hydroxylase (TH)...
September 2016: Molecular Medicine Reports
Mark Alan Seeley, Andrew G Georgiadis, Wudbhav N Sankar
Throughout development, the vascular supply to the proximal femur and acetabulum undergoes a series of changes during which it is susceptible to injury. Before age 3 months, the ligamentum teres and lateral epiphyseal arteries are the dominant supply to the developing head. The dominant supply shifts to the lateral epiphyseal vessels by age 18 months. The distinct metaphyseal and epiphyseal circulations of the adult proximal femur form in adolescence when an increasingly rich metaphyseal circulation supplies the subphyseal region, terminating at the physeal plate...
August 2016: Journal of the American Academy of Orthopaedic Surgeons
Diana Kuh, Stella G Muthuri, Adam Moore, Tim J Cole, Judith E Adams, Cyrus Cooper, Rebecca Hardy, Kate A Ward
OBJECTIVES: To investigate the effect of pubertal timing, assessed in adolescence, on bone size, strength and density in men and women in early old age. DESIGN: A British birth cohort study with prospective indicators of pubertal timing based on age at menarche, clinical assessment of pubertal stage, and growth tempo from serial height measures, and bone measures derived from peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA) at 60-64 years of age among 866 women and 792 men...
July 10, 2016: International Journal of Epidemiology
Caleb A Ford, Niamh C Nowlan, Stavros Thomopoulos, Megan L Killian
The mechanical loading environment influences the development and maturation of joints. In this study, the influence of imbalanced muscular loading on joint development was studied using localized chemical denervation of hip stabilizing muscle groups in neonatal mice. It was hypothesized that imbalanced muscle loading, targeting either gluteal muscles or quadriceps muscles, would lead to bilateral hip joint asymmetry, as measured by acetabular coverage, femoral head volume and bone morphometry, and femoral-acetabular shape...
July 8, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Jae-Young Hong, Keon-Woo Kim, Seung-Woo Suh, Si-Young Park, Jae-Hyuk Yang
STUDY DESIGN: Radiographic analysis with scoliosis patients. OBJECTIVES: To analyze correlations between sagittal spinal alignment and coronal scoliotic curvature. SUMMARYOF BACKGROUND DATA: Sagittal spinal alignment and scoliosis may have a significant relationship, and schematic analysis is needed. METHODS: The study group was comprised of 163 patients with adolescent idiopathic scoliosis. Subjects underwent antero-posterior and lateral radiographs of the whole spine including hip joints...
June 28, 2016: Clinical Spine Surgery
Elisa V Bandera, Stephanie H Fay, Edward Giovannucci, Michael F Leitzmann, Rachel Marklew, Anne McTiernan, Amy Mullee, Isabelle Romieu, Inger Thune, Ricardo Uauy, Martin J Wiseman
Anthropometric measures relating to body size, weight and composition are increasingly being associated with cancer risk and progression. Whilst practical in epidemiologic research, where population-level associations with disease are revealed, it is important to be aware that such measures are imperfect markers of the internal physiological processes that are the actual correlates of cancer development. Body mass index (BMI), the most commonly used marker for adiposity, may mask differences between lean and adipose tissue, or fat distribution, which varies across individuals, ethnicities, and stage in the lifespan...
December 1, 2016: International Journal of Cancer. Journal International du Cancer
Joanna Wawrzuta, Kate L Willoughby, Charlotte Molesworth, Soon Ghee Ang, Benjamin J Shore, Pam Thomason, H Kerr Graham
AIM: We studied 'hip health' in a population-based cohort of adolescents and young adults with cerebral palsy to investigate associations between hip morphology, pain, and gross motor function. METHOD: Ninety-eight young adults (65 males, 33 females) from the birth cohort were identified as having developed hip displacement (migration percentage >30) and were reviewed at a mean age of 18 years 10 months (range 15-24y). Hip morphology was classified using the Melbourne Cerebral Palsy Hip Classification Scale (MCPHCS)...
June 17, 2016: Developmental Medicine and Child Neurology
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