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https://www.readbyqxmd.com/read/28102733/plk1-polo-like-kinase-1-inhibits-mtor-complex-1-and-promotes-autophagy
#1
Stefanie Ruf, Alexander Martin Heberle, Miriam Langelaar-Makkinje, Sara Gelino, Deepti Wilkinson, Carolin Gerbeth, Jennifer Jasmin Schwarz, Birgit Holzwarth, Bettina Warscheid, Chris Meisinger, Marcel A T M van Vugt, Ralf Baumeister, Malene Hansen, Kathrin Thedieck
Mechanistic target of rapamycin complex 1 (MTORC1) and PLK1 (polo like kinase 1) are major drivers of cancer cell growth and proliferation, and inhibitors of both protein kinases are currently being investigated in clinical studies. To date, MTORC1's and PLK1's functions are mostly studied separately, and reports on their mutual crosstalk are scarce. Here, we identify PLK1 as a physical MTORC1 interactor in human cancer cells. PLK1 inhibition enhances MTORC1 activity under nutrient sufficiency and in starved cells, and PLK1 directly phosphorylates the MTORC1 component RPTOR/RAPTOR in vitro...
January 19, 2017: Autophagy
https://www.readbyqxmd.com/read/28048459/we-g-204-01-building-a-career-in-academic-medical-physics-the-hardest-and-best-job-you-will-ever-have
#2
J Hazle
While many indicators for academic medical physics are distressing - jobs are tight, demands on clinical time are high (and getting worse) and national funding has been flat for several years (meaning less money in reality) the present is perhaps one of the most exciting times in cancer research history, and medical physicists have an opportunity to make a difference. Many of us predict the impact of medical physics on cancer research over the next decade to be more significant than ever. Why is that? First, medical imaging is used for every cancer patient in developed countries...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047034/we-d-204-02-errors-and-process-improvements-in-radiation-therapy
#3
D Fontenla
: Speakers in this session will present overview and details of a specific rotation or feature of their Medical Physics Residency Program that is particularly exceptional and noteworthy. The featured rotations include foundational topics executed with exceptional acumen and innovative educational rotations perhaps not commonly found in Medical Physics Residency Programs. A site-specific clinical rotation will be described, where the medical physics resident follows the physician and medical resident for two weeks into patient consultations, simulation sessions, target contouring sessions, planning meetings with dosimetry, patient follow up visits, and tumor boards, to gain insight into the thought processes of the radiation oncologist...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046839/we-g-204-02-so-you-want-to-do-research-two-approaches-to-beginning-a-career-in-medical-physics-research
#4
J Deasy
While many indicators for academic medical physics are distressing - jobs are tight, demands on clinical time are high (and getting worse) and national funding has been flat for several years (meaning less money in reality) the present is perhaps one of the most exciting times in cancer research history, and medical physicists have an opportunity to make a difference. Many of us predict the impact of medical physics on cancer research over the next decade to be more significant than ever. Why is that? First, medical imaging is used for every cancer patient in developed countries...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046388/we-g-204-00-post-graduate-training-of-the-next-generation-of-academic-medical-physicists
#5
John Hazle
While many indicators for academic medical physics are distressing - jobs are tight, demands on clinical time are high (and getting worse) and national funding has been flat for several years (meaning less money in reality) the present is perhaps one of the most exciting times in cancer research history, and medical physicists have an opportunity to make a difference. Many of us predict the impact of medical physics on cancer research over the next decade to be more significant than ever. Why is that? First, medical imaging is used for every cancer patient in developed countries...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28017705/provision-of-rehabilitation-services-in-residential-care-facilities-evidence-from-a-national-survey
#6
Soumitra S Bhuyan, Aastha Chandak, Niodita Gupta, David Wyant, Jungyoon Kim, Jay Bhatt, Ayesha Singh, Sean Gilmore, SangNam Ahn, Cyril F Chang
OBJECTIVE: The objective of this study is to examine the association between organizational factors and provision of rehabilitation services that include physical therapy (PT) and occupational therapy (OT) in Residential Care Facilities in the United States. DESIGN: This is a cross-sectional, observational study conducted using a national sample from the 2010 National Survey of Residential Care Facilities (NSRCF) conducted by the Center for Disease Control and Prevention's National Center for Health Statistics...
December 22, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27982486/the-effect-of-laughter-therapy-on-the-quality-of-life-of-nursing-home-residents
#7
Nilgün Kuru, Gülümser Kublay
AIMS AND OBJECTIVES: To carry out laughter therapy and evaluate its effect on the quality of life of nursing home residents. BACKGROUND: By improving the quality of life of residents living in nursing homes and allowing them to have a healthier existence, their lives can be extended. Therefore, interventions impacting the quality of life of older adults are of critical importance. DESIGN: Quasi-experimental design. METHOD: The study was conducted between March 2 and May 25, 2015...
December 16, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27910052/a-needleless-liquid-jet-injection-delivery-approach-for-cardiac-gene-therapy
#8
Anthony S Fargnoli, Michael G Katz, Charles R Bridges
Fundamentally, cardiac gene therapy clinical trials have demonstrated that route efficiency is paramount in achieving maximum myocardial expression within safety limits. Gene transfer phenomena are largely influenced by physical transport principles (i.e., pressure, residence time, dispersion trafficking, mechanical resistance) that are independent of therapeutic characteristics. An alternative to intracoronary infusion methods, in an effort to improve efficiency in terms of cardiac specificity, is direct myocardial delivery via surgical injection...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27829573/advancing-interprofessional-primary-health-care-services-in-rural-settings-for-people-with-chronic-low-back-disorders-protocol-of-a-community-based-randomized-controlled-trial
#9
Brenna Bath, Stacey Lovo Grona, Stephan Milosavljevic, Nazmi Sari, Biaka Imeah, Megan E O'Connell
BACKGROUND: Chronic low back disorders (CLBDs) are a substantial burden on individuals and societies, and impact up to 20% of Canadians. Rural and remote residents are approximately 30% more likely to have CLBDs. Reduced access to appropriate team-based health services, including physical therapy, is a key factor that may magnify the impact of CLBD on pain, physical function, overall quality of life, health-related system costs, and individual costs. OBJECTIVE: The purpose of this project is to evaluate the validity, comparative effectiveness, costs, barriers, and facilitators of an interprofessional management approach for people with CLBDs, delivered via telehealth...
November 9, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27776786/preventing-falls-in-assisted-living-results-of-a-quality-improvement-pilot-study
#10
Sheryl Zimmerman, Angela Greene, Philip D Sloane, Madeline Mitchell, Carol Giuliani, Kirsten Nyrop, Edith Walsh
Residents of assisted living (AL) communities are at high risk for falls, which result in negative outcomes and high health care costs. Adapting effective falls prevention programs for AL quality improvement (QI) has the potential to reduce falls, improve resident quality of life, and reduce costs. This project tested the feasibility and outcomes of an evidence-based multi-component QI program, the Assisted Living Falls Prevention and Monitoring Program (AL-FPMP). Resident posture and gait improved, likely due to exercise and/or physical therapy...
October 21, 2016: Geriatric Nursing
https://www.readbyqxmd.com/read/27765770/pim-1l-protects-cell-surface-resident-abca1-from-lysosomal-degradation-in-hepatocytes-and-thereby-regulates-plasma-high-density-lipoprotein-level
#11
Akira Katsube, Hisamitsu Hayashi, Hiroyuki Kusuhara
OBJECTIVE: ATP-binding cassette transporter A1 (ABCA1) exerts an atheroprotective action through the biogenesis of high-density lipoprotein in hepatocytes and prevents the formation of foam cells from macrophages. Controlling ABCA1 is a rational approach to improving atherosclerotic cardiovascular disease. Although much is known about the regulatory mechanism of ABCA1 synthesis, the molecular mechanism underpinning its degradation remains to be clearly described. APPROACH AND RESULTS: ABCA1 possesses potential sites of phosphorylation by serine/threonine-protein kinase Pim-1 (Pim-1)...
October 20, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27759337/management-practices-in-indian-patients-with-uncontrolled-hypertension
#12
Rajkumar Bharatia, Manoj Chitale, Ganesh Narain Saxena, Raman Ganesh Kumar, Chikkalingaiah, Abhijit Trailokya, Kalpesh Dalvi, Suhas Talele
INTRODUCTION: Hypertension (HTN), being a major risk factor for cardiovascular diseases (CVDs), is an important issue of medical and public health. High blood pressure (BP) is ranked as the third most important risk factor for attributable burden of disease in south Asia (2010). Hypertension (HTN) exerts a substantial public health burden on cardiovascular health status and healthcare systems in India. Uncontrolled hypertension among adults with hypertension is associated with increased mortality...
July 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27754000/db-02-2-strict-control-of-hypertension-in-the-frail-elderly-is-it-beneficial-con
#13
Hiromi Rakugi
European guidelines (ESH-ESC2013) for the elderly have discussed well about treatment blood pressure (BP) levels and targeting BP levels. In general, elderly patients with systolic BP (SBP) ≥160 mmHg including individuals older than 80 years in good physical and mental conditions are recommended reducing SBP to between 150 and 140 mmHg. Furthermore, fit elderly patients <80 years old are recommended to consider antihypertensive treatment at SBP values ≥140 mmHg with a target SBP <140 mmHg. On the other hand, frail elderly patients are recommended to leave decisions on antihypertensive therapy to the treating physician, and based on monitoring of the clinical effects of treatment...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27742077/clinical-residency-training-is-it-essential-to-the-doctor-of-nursing-practice-for-nurse-practitioner-preparation
#14
Doreen C Harper, Teena M McGuinness, Jean Johnson
BACKGROUND: The Doctor of Nursing Practice (DNP) degree positions nurse practitioners (NPs) and other advanced practice registered nurses, with clinical competencies similar to other disciplines requiring doctoral education (medicine, physical therapy, psychology, and pharmacy). In addition, all these disciplines also offer residencies. However, nursing is the only discipline that does not require a doctoral degree and/or have a systematic approach to residency training for advanced practice roles...
August 31, 2016: Nursing Outlook
https://www.readbyqxmd.com/read/27739264/st-segment-elevated-acute-myocardial-infarction-changing-profile-over-last-24-years
#15
Trinath Kumar Mishra, Biswajit Das
BACKGROUND: Coronary artery disease (CAD) is rising in epidemic proportions with India not being an exception. CAD in Indian scenario has its onset at a younger age with multitude of risk factors. OBJECTIVE: This study was carried out to obtain complete information about demographic profile, risk factors, clinical scenario, therapeutic modalities, natural course, outcome and changing profile of acute ST-segment elevated myocardial infarction (STEMI) patients. METHODS: This cross-sectional study was conducted in 45,122 acute STEMI patients admitted 1st March 1990 to 1st March 2014...
June 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27679723/renew-a-renal-redesign-project-in-predialysis-patient-care
#16
Josephine Sau Fan Chow, Kim Jobburn, Margaret Chapman, Michael Suranyi
BACKGROUND: An ageing population and geographical growth, along with an increase in the number of people that reside in specific location, are increasing the demand for renal replacement therapies. Hospital-based haemodialysis units are struggling to cope with the associated physical, staffing and cost demands. Home-based dialysis therapies are known to be more cost effective with superior social, physical health and survival outcomes. METHODS: 'RENEW, a renal redesign project, examined the pre-dialysis health care experience of renal patients to find opportunities to improve patient care outcomes and increase the uptake of home-based dialysis therapies...
October 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27676320/headache-disorders-may-be-a-risk-factor-for-the-development-of-new-onset-hypothyroidism
#17
Andrew T Martin, Susan M Pinney, Changchun Xie, Robert L Herrick, Yun Bai, Jeanette Buckholz, Vincent T Martin
OBJECTIVE: To determine whether headache disorders are a risk factor for the development of new onset hypothyroidism. BACKGROUND: Past studies have reported associations between headache disorders and hypothyroidism, but the directionality of the association is unknown. METHODS: This was a longitudinal retrospective cohort study using data from the Fernald Medical Monitoring Program (FMMP). Residents received physical examinations and thyroid function testing every 3 years during the 20 year program...
January 2017: Headache
https://www.readbyqxmd.com/read/27642911/db-02-2-strict-control-of-hypertension-in-the-frail-elderly-is-it-beneficial-con
#18
Hiromi Rakugi
European guidelines (ESH-ESC2013) for the elderly have discussed well about treatment blood pressure (BP) levels and targeting BP levels. In general, elderly patients with systolic BP (SBP) ≥160 mmHg including individuals older than 80 years in good physical and mental conditions are recommended reducing SBP to between 150 and 140 mmHg. Furthermore, fit elderly patients <80 years old are recommended to consider antihypertensive treatment at SBP values ≥140 mmHg with a target SBP <140 mmHg. On the other hand, frail elderly patients are recommended to leave decisions on antihypertensive therapy to the treating physician, and based on monitoring of the clinical effects of treatment...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27583245/from-here-to-there-progenitor-cells-and-stem-cells-are-everywhere-in-lung-vascular-remodeling
#19
REVIEW
Rebecca L Heise, Patrick A Link, Laszlo Farkas
The field of stem cell biology, cell therapy, and regenerative medicine has expanded almost exponentially, in the last decade. Clinical trials are evaluating the potential therapeutic use of stem cells in many adult and pediatric lung diseases with vascular component, such as bronchopulmonary dysplasia (BPD), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), or pulmonary arterial hypertension (PAH). Extensive research activity is exploring the lung resident and circulating progenitor cells and their contribution to vascular complications of chronic lung diseases, and researchers hope to use resident or circulating stem/progenitor cells to treat chronic lung diseases and their vascular complications...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27538884/effectiveness-of-interventions-utilising-telephone-follow-up-in-reducing-hospital-readmission-within-30-days-for-individuals-with-chronic-disease-a-systematic-review
#20
Amanda Jayakody, Jamie Bryant, Mariko Carey, Breanne Hobden, Natalie Dodd, Robert Sanson-Fisher
BACKGROUND: Rates of readmission to hospital within 30 days are highest amongst those with chronic diseases. Effective interventions to reduce unplanned readmissions are needed. Providing support to patients with chronic disease via telephone may help prevent unnecessary readmission. This systematic review aimed to determine the methodological quality and effectiveness of interventions utilising telephone follow up (TFU) alone or in combination with other components in reducing readmission within 30 days amongst patients with cardiovascular disease, chronic respiratory disease and diabetes...
2016: BMC Health Services Research
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