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https://www.readbyqxmd.com/read/29304997/cellular-biomechanics-in-skeletal-muscle-regeneration
#1
Edward W Li, Olivia C McKee-Muir, Penney M Gilbert
Satellite cells, adult stem cells in skeletal muscle tissue, reside within a mechanically dynamic three-dimensional microenvironment. With each contraction-relaxation cycle, a satellite cell is expected to experience tensile, shear, and compressive stresses, and through cell-extracellular matrix interactions, also gauge the stiffness of the niche. Via mechanoreceptors, cells can sense these biophysical parameters of the niche, which serve to physically induce conformational changes that impact biomolecule activity, and thereby alter downstream signal transduction pathways and ultimately cell fate...
2018: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/29298407/a-hybrid-form-of-telemedicine-a-unique-way-to-extend-intensive-care-service-to-neonates-in-medically-underserved-areas
#2
Abhishek Makkar, Mike McCoy, Gene Hallford, Marilyn Escobedo, Edgardo Szyld
BACKGROUND: More than 90% of neonatal intensive care units (NICUs) in the United States are in urban areas, denying rural residents' easy NICU access. Telemedicine use for patient contact and management, although studied in adults and children, is understudied in neonates. A hybrid telemedicine system, with 24/7 neonatal nurse practitioner coverage and with a neonatologist physically present 3 days per week and telemedicine coverage the remaining days, was recently implemented at Comanche County Memorial Hospital's (CCMH) Level II NICU...
January 3, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29278305/biological-characteristics-of-human-menstrual-blood-derived-endometrial-stem-cells
#3
Yanli Liu, Rongcheng Niu, Fen Yang, Yan Yan, Shengying Liang, Yuliang Sun, Ping Shen, Juntang Lin
Successful isolation of human endometrial stem cells from menstrual blood, namely menstrual blood-derived endometrial stem cells (MenSCs), has provided enticing alternative seed cells for stem cell-based therapy. MenSCs are enriched in the self-regenerative tissue, endometrium, which shed along the periodic menstrual blood and thus their acquisition involves no physical invasiveness. However, the impact of the storage duration of menstrual blood prior to stem cell isolation, the age of the donor, the number of passages on the self-renewing of MenSCs, the paracrine production of biological factors in MenSCs and expression of adhesion molecules on MenSCs remain elusive...
December 26, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29229109/evaluation-and-quantification-of-treatment-preferences-for-patients-with-asthma-or-copd-using-discrete-choice-experiment-surveys
#4
Henrik Svedsater, David Leather, Terry Robinson, Helen Doll, Beenish Nafees, Lisa Bradshaw
INTRODUCTION: To investigate treatment preferences of patients with asthma or chronic obstructive pulmonary disease (COPD), previously identified influential treatment factors were used to develop a discrete choice experiment (DCE) survey. METHODS: An internet-based survey was conducted with UK-resident adults (recruited using a commercial panel) who were currently receiving asthma/COPD treatment and had not taken part in the previous phase of this study (qualitative interviews to understand patient burden, life impact and treatment preferences)...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29220527/inverse-association-between-neck-pain-and-all-cause-mortality-in-community-dwelling-older-adults
#5
Antonio Muscari, Giampaolo Bianchi, Paola Forti, Donatella Magalotti, Paolo Pandolfi, Marco Zoli
Objective: In a previous study, we found an apparent protective effect of neck pain on all-cause mortality in subjects older than age 85 years. The present longitudinal investigation was performed to verify this unexpected finding in a larger sample and to establish its significance. Design: Population follow-up study. Setting: Three towns of Northern Italy. Subjects: We examined 5,253 community-dwelling residents age 65-102 years (55% female)...
December 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29200624/exercise-using-a-robotic-knee-orthosis-in-stroke-patients-with-hemiplegia
#6
Shuhei Iida, Dai Kawakita, Takuya Fujita, Hirohumi Uematsu, Takahisa Kotaki, Kikuko Ikeda, Chikara Aoki
[Purpose] The Robotics Knee Orthosis (RKO) is a knee-ankle-foot orthosis with active robot assisting technology. The purpose of this study is to examine the effects of exercise with the RKO (RKO-exercise) in stroke patients with hemiplegia. [Subjects and Methods] Participants were nine stroke patients with hemiplegia, residing in a convalescent rehabilitation ward. The duration of the RKO-exercise program was 10 days. Participants were evaluated three times prior to intervention, once after intervention, and one month post intervention...
November 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29181256/sports-physical-therapy-curricula-in-physical-therapist-professional-degree-programs
#7
Edward P Mulligan, Julie DeVahl
Background: The specialty niche of sports physical therapy has grown at a significant rate over the past 40 years. Despite this growth there is little information or direction from the physical therapy education accreditation body or professional association to guide academic programs on the interest or necessity of this type of practice content in physical therapy professional degree programs. Purpose: The purpose of this survey study is to report on the prevalence, attitudes, barriers, resources, and faculty expertise in providing required or elective sports physical therapy course work...
October 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29158832/clinical-translation-and-first-in-human-use-of-44sc-sc-psma-617-for-pet-imaging-of-metastasized-castrate-resistant-prostate-cancer
#8
Elisabeth Eppard, Ana de la Fuente, Martina Benešová, Ambreen Khawar, Ralph A Bundschuh, Florian C Gärtner, Barbara Kreppel, Klaus Kopka, Markus Essler, Frank Rösch
BACKGROUND: Various trivalent radiometals are well suited for labeling of DOTA-conjugated variants of Glu-ureido-based prostate-specific membrane antigen (PSMA) inhibitors. The DOTA-conjugate PSMA-617 has proven high potential in PSMA radioligand therapy (PSMA-RLT) of prostate cancer as well as PET imaging when labeled with lutetium-177 and gallium-68 respectively. Considering the relatively short physical half-life of gallium-68 this positron emitter precludes prolonged acquisition periods, as required for pre-therapeutic dosimetry or intraoperative applications...
2017: Theranostics
https://www.readbyqxmd.com/read/29141626/health-related-quality-of-life-of-hiv-aids-patients-on-highly-active-anti-retroviral-therapy-at-a-university-referral-hospital-in-ethiopia
#9
Abdrrahman Shemsu Surur, Fitsum Sebsibe Teni, Wondwessen Wale, Yihenew Ayalew, Betel Tesfaye
BACKGROUND: Highly active antiretroviral therapy improves the longevity of patients living with HIV/AIDS. We conducted the study in order to assess health related quality of life of HIV/AIDS patients and the association of socio-demographic and disease related variables with health related quality of life. METHODS: Health facility based cross-sectional study among 400 HIV/AIDS patients taking highly active anti-retroviral therapy from Gondar University referral hospital was conducted...
November 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29043770/a-novel-negative-allosteric-modulator-selective-for-glun2c-2d-containing-nmda-receptors-inhibits-synaptic-transmission-in-hippocampal-interneurons
#10
Sharon A Swanger, Katie M Vance, Timothy M Acker, Sommer S Zimmerman, John O DiRaddo, Scott J Myers, Christoffer Bundgaard, Cara A Mosley, Samantha L Summer, David S Menaldino, Henrik S Jensen, Dennis C Liotta, Stephen F Traynelis
N-Methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in numerous neurological disorders. NMDARs typically comprise two GluN1 and two GluN2 subunits. The four GluN2 subtypes (GluN2A-GluN2D) have distinct functional properties and gene expression patterns, which contribute to diverse functional roles for NMDARs in the brain. Here, we present a series of GluN2C/2D-selective negative allosteric modulators built around a N-aryl benzamide (NAB) core...
November 2, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28969949/variability-and-comprehensiveness-of-north-american-online-available-physical-therapy-protocols-following-hip-arthroscopy-for-femoroacetabular-impingement-and-labral-repair
#11
Gregory L Cvetanovich, Vincent Lizzio, Fabien Meta, Derek Chan, Ira Zaltz, Shane J Nho, Eric C Makhni
PURPOSE: To assess comprehensiveness and variability of postoperative physical therapy protocols published online following hip arthroscopy for femoroacetabular impingement (FAI) and/or labral repair. METHODS: Surgeons were identified by the International Society for Hip Arthroscopy "Find a Surgeon" feature in North America (http://www.isha.net/members/, search August 10, 2016). Exclusion criteria included nonsurgeons and protocols for conditions other than hip arthroscopy for FAI and/or labral tear...
November 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28948436/mapping-health-related-quality-of-life-scores-from-fact-g-faact-and-facit-f-onto-preference-based-eq-5d-5l-utilities-in-non-small-cell-lung-cancer-cachexia
#12
Michela Meregaglia, Ludovica Borsoi, John Cairns, Rosanna Tarricone
BACKGROUND: Health-related quality of life (HRQoL) measurements from disease-specific tools cannot be directly used in economic evaluations. This study aimed to develop and validate mapping algorithms that predicted EuroQol 5-Dimensions 5-Levels (EQ-5D-5L) utilities from Functional Assessment of Anorexia-Cachexia Therapy (FAACT) and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and their common component (Functional Assessment of Cancer Therapy-General-FACT-G) in patients with non-small cell lung cancer cachexia...
September 25, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28895282/a-patient-safety-education-program-in-a-medical-physics-residency
#13
Eric C Ford, Matthew Nyflot, Matthew B Spraker, Gabrielle Kane, Kristi R G Hendrickson
Education in patient safety and quality of care is a requirement for radiation oncology residency programs according to accrediting agencies. However, recent surveys indicate that most programs lack a formal program to support this learning. The aim of this report was to address this gap and share experiences with a structured educational program on quality and safety designed specifically for medical physics therapy residencies. Five key topic areas were identified, drawn from published recommendations on safety and quality...
September 12, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28891033/targeted-alpha-therapy-of-mcrpc-dosimetry-estimate-of-213-bismuth-psma-617
#14
Clemens Kratochwil, Karl Schmidt, Ali Afshar-Oromieh, Frank Bruchertseifer, Hendrik Rathke, Alfred Morgenstern, Uwe Haberkorn, Frederik L Giesel
PURPOSE: PSMA-617 is a small molecule targeting the prostate-specific membrane antigen (PSMA). In this work, we estimate the radiation dosimetry for this ligand labeled with the alpha-emitter (213)Bi. METHODS: Three patients with metastatic prostate cancer underwent PET scans 0.1 h, 1 h, 2 h, 3 h, 4 h and 5 h after injection of (68)Ga-PSMA-617. Source organs were kidneys, liver, spleen, salivary glands, bladder, red marrow and representative tumor lesions...
September 11, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28890435/pain-control-in-thoracic-oncology
#15
Christine Peeters-Asdourian, Gilbert Massard, Paragi H Rana, Paul Van Houtte, Andrew P White, Bogdan Grigoriu, Dominique Lossignol, Mohammed Almalki, Jean Alexiou, Jean-Luc Engelholm, Jean-Paul Sculier
This review of pain management in lung cancer is based on the presentation of four cases of thoracic oncology patients with pain at various stages of their disease. The approach will be multidisciplinary, involving a thoracic oncologist, radiologist, thoracic and orthopaedic spine surgeon, radiation therapist, pain medicine specialist, and palliative care specialist. This multispecialty approach to the management of different painful presentations in thoracic oncology will demonstrate the complexity of each case and the improved patient outcomes which result from the involvement of different disciplines working in concert...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28859037/health-related-quality-of-life-and-associated-factors-among-thalassemia-major-patients-southeast-of-iran
#16
Ali Bazi, Omolbanin Sargazi-Aval, Amin Safa, Ebrahim Miri-Moghaddam
Low quality of life (QOL) is a feature that has been overlooked in thalassemia major (TM) patients. Our aim was to assess QOL in school-aged TM patients in Zabol city and surrounding rural areas in southeast of Iran. The study was performed in 2014. QOL was evaluated using Pediatric Quality of Life Inventory 4 (PedsQL4) questionnaire addressing physical, emotional, social, and educational, along with psychological health in 80 TM patients. Also, 80 age-matched and sex-matched subjects without any chronic illness served as control group...
October 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28801082/-how-to-videos-improve-residents-performance-of-essential-perioperative-electronic-medical-records-and-clinical-tasks
#17
Veronica Zoghbi, Robert C Caskey, Kristoffel R Dumon, Jacqueline M Soegaard Ballester, Ari D Brooks, Jon B Morris, Daniel T Dempsey
OBJECTIVE: The ability to use electronic medical records (EMR) is an essential skill for surgical residents. However, frustration and anxiety surrounding EMR tasks may detract from clinical performance. We created a series of brief, 1-3 minutes "how to" videos demonstrating 7 key perioperative EMR tasks: booking OR cases, placing preprocedure orders, ordering negative-pressure wound dressing supplies, updating day-of-surgery history and physical notes, writing brief operative notes, discharging patients from the postanesthesia care unit, and checking vital signs...
August 8, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28794663/physician-perspectives-on-education-training-and-implementation-of-complementary-and-alternative-medicine
#18
Sejal J Patel, Kathi J Kemper, Joseph P Kitzmiller
Over recent decades, the demand for complementary and alternative medicine (CAM) has continued to rise in the US. Like the practice of traditional Western medicine, CAM is associated with not only significant health benefits but also significant risks. Unlike traditional Western medicine, however, much of CAM use is less regulated and often occurs unbeknownst to a patient's medical doctor. The use of herbals, dietary supplements, and over-the-counter (OTC) medications can result in adverse effects, and many significant interactions can occur when their use is combined with allopathic medications...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28717892/a-population-based-study-of-injuries-to-the-brachial-plexus-and-to-the-peripheral-nerves-of-the-shoulder-girdle-and-upper-limb-in-the-italian-region-friuli-venezia-giulia
#19
Francesca Valent, Roberto Eleopra, Paolo Manganotti, Paolo Passadore
The aim of this study was to estimate the incidence, identify the causes, and explore treatments of the injuries to the brachial plexus and peripheral nerves of the shoulder girdle and upper limb in the 1,220,000-inhabitant Italian region Friuli Venezia Giulia.We linked at the individual patient level various administrative databases using an anonymous stochastic key: list of residents, hospital discharge, emergency department, and outpatient care prescriptions database. We abstracted hospital discharge records with at least one discharge diagnosis code ICD-9-CM 953...
July 17, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28702683/blood-on-the-tracks-hematopoietic-stem-cell-endothelial-cell-interactions-in-homing-and-engraftment
#20
REVIEW
Julie R Perlin, Audrey Sporrij, Leonard I Zon
Cells of the hematopoietic system undergo rapid turnover. Each day, humans require the production of about one hundred billion new blood cells for proper function. Hematopoietic stem cells (HSCs) are rare cells that reside in specialized niches and are required throughout life to produce specific progenitor cells that will replenish all blood lineages. There is, however, an incomplete understanding of the molecular and physical properties that regulate HSC migration, homing, engraftment, and maintenance in the niche...
August 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
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