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https://www.readbyqxmd.com/read/27914178/longitudinal-assessment-of-examiner-experience-and-the-accuracy-of-sonographic-fetal-weight-estimation-at-term
#1
Florian Faschingbauer, Jutta Heimrich, Eva Raabe, Sven Kehl, Michael Schneider, Matthias Schmid, Matthias W Beckmann, Tobias Hepp, Anika Lübke, Andreas Mayr, Ralf L Schild
OBJECTIVES: To evaluate the influence of examiner experience on the accuracy of sonographic weight estimation and to further analyze examiners' individual learning curves. METHODS: In this multicenter study, 4613 sonographic weight estimations performed by 18 examiners at the beginning of their ultrasound training were included. To assess the effect of experience on the accuracy of weight estimation, a multivariable mixed regression model analysis was performed, with percentage error and absolute percentage error as outcome variables and the examiner, the examiner's experience (number of examinations), birth weight, gestational age, scan-to-delivery interval, and maternal body mass index as fixed effects and the perinatal center as random intercepts...
December 3, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27913867/comparison-of-different-concepts-for-interpretation-of-chromosomal-aberrations-in-urothelial-cells-detected-by-fluorescence-in-situ-hybridization
#2
Johannes Mischinger, Lutz Philipp Guttenberg, Jörg Hennenlotter, Georgios Gakis, Stefan Aufderklamm, Steffen Rausch, Eva Neumann, Jens Bedke, Stefan Kruck, Christian Schwentner, Arnulf Stenzl, Tilman Todenhöfer
PURPOSE: Urine fluorescence in situ hybridization (FISH) has become a broadly used marker for noninvasive detection of bladder cancer (BC). However, it has been discussed whether the interpretation algorithm proposed by the manufacturer could be improved. Aim of the present study was to compare alternative evaluation strategies of FISH for detection of BC. METHODS: We included 1048 patients suspicious for BC, who underwent urine FISH examination before cystoscopy (diagnostic cohort)...
December 2, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27913721/application-based-hearing-screening-in-the-elderly-population
#3
Leonid Livshitz, Reem Ghanayim, Carmi Kraus, Raymond Farah, Ella Even-Tov, Yaniv Avraham, Adi Sharabi-Nov, Peter Gilbey
OBJECTIVES: The effects of age-related hearing loss are severe. Early detection is essential for maximum benefit. However, most hearing-impaired adults delay obtaining treatment. Diagnostic hearing testing at an appropriate facility is impractical, and new methods for screening audiometry aim to provide easy access for patients and reliable outcomes. The purpose of this study was to examine the accuracy of application-based hearing screening in an elderly population. METHODS: The uHear application was downloaded to an iPad...
January 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27913298/a-novel-monoclonal-antibody-suitable-for-the-detection-of-leukotriene-b4
#4
Steffi Lütkecosmann, Axel Warsinke, Winfried Tschöpe, Rüdiger Eichler, Katja Hanack
Leukotriene B4 as an inflammatory mediator is an important biomarker for different respiratory diseases like asthma, chronic obstructive pulmonary disease or cystic lung fibrosis. Therefore the detection of LTB4 is helpful in the diagnosis of these pulmonary diseases. However, until now its determination in exhaled breath condensates suffers from problems of accuracy. Reasons for that could be improper sample collection and preparation methods of condensates and the lack of consistently assay specificity and reproducibility of the used immunoassay detection system...
November 29, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27912204/incremental-diagnostic-value-of-combined-quantitative-and-qualitative-parameters-of-magnetocardiography-to-detect-coronary-artery-disease
#5
Eun-Seok Shin, Yat-Yin Lam, Ae-Young Her, Johannes Brachmann, Friedrich Jung, Jai-Wun Park
BACKGROUND/OBJECTIVES: Magnetocardiography (MCG) has been proposed as a non-invasive and functional technique with high accuracy for diagnosis of myocardial ischemia. This study sought to investigate the incremental diagnostic value of combined quantitative and qualitative parameters of MCG to detect coronary artery disease (CAD). METHODS: Ninety six patients with suspected CAD who underwent coronary angiography were enrolled in the analysis to test the diagnostic accuracy of 2 MCG parameters (a quantitative parameter of the percent change of ST-segment fluctuation score and a qualitative parameter of non-dipole phenomenon)...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27911967/the-value-of-physical-examination-a-new-conceptual-framework
#6
Junaid Zaman, Abraham Verghese, Andrew Elder
The physical examination defines medical practice, yet its role is being questioned increasingly, with statistical comparisons of diagnostic accuracy often the sole metric used against newer technologies. We set out to highlight seven ways in which the physical examination has value beyond diagnostic accuracy to reaffirm its place in the core skills of a physician and guide future research, teaching, and curriculum design. We show that this more comprehensive approach to the physical examination of its "utility" beyond that of reaching a diagnosis can be beneficial to both doctor and patient...
December 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27911963/teaching-evidence-based-physical-diagnosis-six-bedside-lessons
#7
Steven McGee
Evidence-based physical diagnosis is an essential part of the bedside curriculum. By using the likelihood ratio, a simple measure of diagnostic accuracy, teachers can quickly adapt this approach to their bedside teaching. Six recurring themes in evidence-based physical diagnosis are fully reviewed, with examples, in this article.
December 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27911922/nucleic-acid-amplification-testing-and-sequencing-combined-with-acid-fast-staining-in-needle-biopsy-lung-tissues-for-the-diagnosis-of-smear-negative-pulmonary-tuberculosis
#8
Faming Jiang, Weiwei Huang, Ye Wang, Panwen Tian, Xuerong Chen, Zongan Liang
BACKGROUND: Smear-negative pulmonary tuberculosis (PTB) is common and difficult to diagnose. In this study, we investigated the diagnostic value of nucleic acid amplification testing and sequencing combined with acid-fast bacteria (AFB) staining of needle biopsy lung tissues for patients with suspected smear-negative PTB. METHODS: Patients with suspected smear-negative PTB who underwent percutaneous transthoracic needle biopsy between May 1, 2012, and June 30, 2015, were enrolled in this retrospective study...
2016: PloS One
https://www.readbyqxmd.com/read/27911315/decreased-expression-of-hsa-mir-4274-in%C3%A2-cerebrospinal-fluid-of-normal-pressure-hydrocephalus-mimics-with-parkinsonian-syndromes
#9
Ivana Jurjević, Masakazu Miyajima, Ikuko Ogino, Chihiro Akiba, Madoka Nakajima, Akihide Kondo, Mika Kikkawa, Mitsuyasu Kanai, Nobutaka Hattori, Hajime Arai
BACKGROUND: Patients presenting with the classical idiopathic normal pressure hydrocephalus (iNPH) triad often show additional parkinsonian spectrum signs. Accurate differential diagnosis strongly influences the long-term outcome of cerebrospinal fluid (CSF) shunting. OBJECTIVE: The aim of this study was to find potential CSF microRNA (miRNA) biomarkers for NPH mimics with parkinsonian syndromes that can reliably distinguish them from iNPH patients. METHODS: Two cohorts of 81 patients (cohort 1, n = 55; cohort 2, n = 26) with possible iNPH who were treated in two centers between January 2011 and May 2014 were studied...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911296/screening-for-mild-cognitive-impairment-and-dementia-with-automated-anonymous-online-and-telephone-cognitive-self-tests
#10
Lisa D Van Mierlo, Hans Wouters, Sietske A M Sikkes, Wiesje M Van der Flier, Niels D Prins, Jonne A E Bremer, Teddy Koene, Hein P J Van Hout
BACKGROUND: Many older people worry about cognitive decline. Early cognitive screening in an anonymous and easily accessible manner may reassure older people who are unnecessarily worried about normal cognitive aging while it may also expedite help seeking in case of suspicious cognitive decline. OBJECTIVE: To develop and validate online and telephone-based automated self-tests of cognitive function. METHODS: We examined the feasibility and validity of the self-tests in a prospective study of 117 participants of whom 34 had subjective cognitive decline (SCD), 30 had mild cognitive impairment (MCI), and 53 had dementia...
November 29, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27911263/contrast-enhanced-us-guided-percutaneous-biopsy-of-anterior-mediastinal-lesions
#11
Dong Yi, Mao Feng, Wang Wen Ping, Ji Zheng Biao, Pei Li Fan
PURPOSE: We aimed to explore the value of contrast-enhanced ultrasonography (CEUS) in guidance of percutaneous biopsy of anterior mediastinal lesions. METHODS: Ninety patients with solitary anterior mediastinal lesions (55 males, 35 females; mean age, 46±4 years) were included. Patients were randomly divided into CEUS group (n=45) and conventional ultrasonography (US) group (n=45). Real-time US-guided core needle (16 G) percutaneous biopsies were performed in all lesions...
December 2, 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27911001/diagnostic-accuracy-of-thyroid-imaging-reporting-and-data-system-in-the-prediction-of-malignancy-in-nodules-with-atypia-and-follicular-lesion-of-undetermined-significance-cytologies
#12
Husniye Baser, Bekir Cakir, Oya Topaloglu, Afra Alkan, Sefika Burcak Polat, Hayriye Tatli Dogan, Mustafa Omer Yazicioğlu, Cevdet Aydin, Reyhan Ersoy
OBJECTIVE: Thyroid Imaging Reporting and Data System (TIRADS) is a simple and reliable reporting system for the prediction of malignancy. We aimed to determine the role of TIRADS in the prediction of malignancy in subcategories of Bethesda Category III, atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS). DESIGN & PATIENTS: A total of 461 nodules with AUS cytology in 450 patients and 179 nodules with FLUS cytology in 168 patients were included...
November 7, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27910677/temperature-gradient-scale-length-measurement-a-high-accuracy-application-of-electron-cyclotron-emission-without-calibration
#13
S Houshmandyar, Z J Yang, P E Phillips, W L Rowan, A E Hubbard, J E Rice, J W Hughes, S M Wolfe
Calibration is a crucial procedure in electron temperature (Te) inference from a typical electron cyclotron emission (ECE) diagnostic on tokamaks. Although the calibration provides an important multiplying factor for an individual ECE channel, the parameter ΔTe/Te is independent of any calibration. Since an ECE channel measures the cyclotron emission for a particular flux surface, a non-perturbing change in toroidal magnetic field changes the view of that channel. Hence the calibration-free parameter is a measure of Te gradient...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910676/in-situ-wavelength-calibration-of-the-edge-cxs-spectrometers-on-jet
#14
E Delabie, N Hawkes, T M Biewer, M G O'Mullane
A method for obtaining an accurate wavelength calibration over the entire focal plane of the JET edge CXS spectrometers is presented that uses a combination of the fringe pattern created with a Fabry-Pérot etalon and a neon lamp for cross calibration. The accuracy achieved is 0.03 Å, which is the same range of uncertainty as when neglecting population effects on the rest wavelength of the CX line. For the edge CXS diagnostic, this corresponds to a flow velocity of 4.5 km/s in the toroidal direction or 1.9 km/s in the poloidal direction...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910670/alignment-and-absolute-wavelength-calibration-of-imaging-bragg-spectrometers
#15
G Bertschinger, O Marchuk, R Barnsley
In the present and the next generation of fusion devices, imaging Bragg spectrometers are key diagnostics to measure plasma parameters in the hot core, especially ion temperature and plasma rotation. The latter quantities are routinely obtained using the Doppler-width and -shift of the emitted spectral lines, respectively. Line shift measurements require absolute accuracies Δλ/λ of about 10 ppm, where λ-is the observed wavelength. For ITER and the present fusion devices, spectral lines of He-and H-like argon, iron, and krypton as well as Ne-like tungsten are foreseen for the measurements...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910667/x-ray-self-emission-imaging-used-to-diagnose-3-d-nonuniformities-in-direct-drive-icf-implosions
#16
A K Davis, D T Michel, R S Craxton, R Epstein, M Hohenberger, T Mo, D H Froula
As hydrodynamics codes develop to increase understanding of three-dimensional (3-D) effects in inertial confinement fusion implosions, diagnostics must adapt to evaluate their predictive accuracy. A 3-D radiation postprocessor was developed to investigate the use of soft x-ray self-emission images of an imploding target to measure the size of nonuniformities on the target surface. Synthetic self-emission images calculated from 3-D simulations showed a narrow ring of emission outside the ablation surface of the target...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910627/bayesian-tomography-and-integrated-data-analysis-in-fusion-diagnostics
#17
Dong Li, Y B Dong, Wei Deng, Z B Shi, B Z Fu, J M Gao, T B Wang, Yan Zhou, Yi Liu, Q W Yang, X R Duan
In this article, a Bayesian tomography method using non-stationary Gaussian process for a prior has been introduced. The Bayesian formalism allows quantities which bear uncertainty to be expressed in the probabilistic form so that the uncertainty of a final solution can be fully resolved from the confidence interval of a posterior probability. Moreover, a consistency check of that solution can be performed by checking whether the misfits between predicted and measured data are reasonably within an assumed data error...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910608/x-ray-transport-and-radiation-response-assessment-xtrra-experiments-at-the-national-ignition-facility
#18
K B Fournier, C G Brown, M F Yeoman, J H Fisher, S W Seiler, D Hinshelwood, S Compton, F R Holdener, G E Kemp, C D Newlander, R P Gilliam, N Froula, M Lilly, J F Davis, Maj A Lerch, B E Blue
Our team has developed an experimental platform to evaluate the x-ray-generated stress and impulse in materials. Experimental activities include x-ray source development, design of the sample mounting hardware and sensors interfaced to the National Ignition Facility's diagnostics insertion system, and system integration into the facility. This paper focuses on the X-ray Transport and Radiation Response Assessment (XTRRA) test cassettes built for these experiments. The test cassette is designed to position six samples at three predetermined distances from the source, each known to within ±1% accuracy...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910405/high-dynamic-range-neutron-time-of-flight-detector-used-to-infer-the-d-t-n-4-he-and-d-d-n-3-he-reaction-yield-and-ion-temperature-on-omega
#19
C J Forrest, V Yu Glebov, V N Goncharov, J P Knauer, P B Radha, S P Regan, M H Romanofsky, T C Sangster, M J Shoup, C Stoeckl
Upgraded microchannel-plate-based photomultiplier tubes (MCP-PMT's) with increased stability to signal-shape linearity have been implemented on the 13.4-m neutron time-of-flight (nTOF) detector at the Omega Laser Facility. This diagnostic uses oxygenated xylene doped with diphenyloxazole C15H11NO + p-bis-(o-methylstyryl)-benzene (PPO + bis-MSB) wavelength shifting dyes and is coupled through four viewing ports to fast-gating MCP-PMT's, each with a different gain to allow one to measure the light output over a dynamic range of 1 × 10(6)...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910340/analysis-method-for-thomson-scattering-diagnostics-in-gamma-10-pdx
#20
K Ohta, M Yoshikawa, R Yasuhara, M Chikatsu, Y Shima, J Kohagura, M Sakamoto, Y Nakasima, T Imai, M Ichimura, I Yamada, H Funaba, T Minami
We have developed an analysis method to improve the accuracies of electron temperature measurement by employing a fitting technique for the raw Thomson scattering (TS) signals. Least square fitting of the raw TS signals enabled reduction of the error in the electron temperature measurement. We applied the analysis method to a multi-pass (MP) TS system. Because the interval between the MPTS signals is very short, it is difficult to separately analyze each Thomson scattering signal intensity by using the raw signals...
November 2016: Review of Scientific Instruments
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