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https://www.readbyqxmd.com/read/29906596/are-we-missing-respiratory-viral-infections-in-infants-and-children-comparison-of-a-hospital-based-quality-management-system-with-standard-of-care
#1
Maren Alchikh, Tim Conrad, Christian Hoppe, Xiaolin Ma, Eeva Broberg, Pasi Penttinen, Janine Reiche, Barbara Biere, Brunhilde Schweiger, Barbara Rath
OBJECTIVES: Hospital-based surveillance of influenza and acute respiratory infections relies on ICD-codes and hospital laboratory reports (Standard-of-Care). It is unclear how many cases are missed with either method, i.e. remain undiagnosed/coded as influenza and other respiratory virus infections. Various influenza-like illness (ILI) definitions co-exist with little guidance on how to use them. We are comparing the diagnostic accuracy of standard surveillance methods with a prospective quality management (QM-Program) at a Berlin children's hospital with the Robert-Koch-Institute (RKI)...
June 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29906594/diagnostic-accuracy-of-a-prototype-rapid-chlamydia-and-gonorrhoea-recombinase-polymerase-amplification-assay-a-multi-centre-cross-sectional-pre-clinical-evaluation
#2
Emma M Harding-Esch, Sebastian S Fuller, S-L Christine Chow, Achyuta V Nori, Mark A Harrison, Mathew Parker, Olaf Piepenburg, Matthew S Forrest, David G Brooks, Rajul Patel, Phillip Hay, Nicola Fearnley, Marcus J Pond, J Kevin Dunbar, Philip D Butcher, Timothy Planche, Catherine M Lowndes, S Tariq Sadiq
OBJECTIVES: Rapid and accurate sexually transmitted infection diagnosis can reduce onward transmission and improve treatment efficacy. We evaluated the accuracy of a 15-minute run-time recombinase polymerase amplification (RPA)-based prototype point-of-care test (TwistDx) for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). METHODS: Prospective, multi-centre study of symptomatic and asymptomatic patients attending three English sexual health clinics. Research samples provided were: additional self-collected vulvo-vaginal swab (SCVS) (females); first-catch urine (FCU) aliquot (females and males)...
June 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29906592/how-to-evaluate-a-diagnostic-test
#3
REVIEW
Mariska M G Leeflang, Franz Allerberger
BACKGROUND: The development of an in vitro diagnostic test from a good idea to a clinically relevant tool takes several steps, with more stringent requirements at every step. AIMS: This article aims to summarize the necessary questions to be asked about a test and to illustrate study designs answering these questions. We also aim to relate the Regulation (EU) 2017/746 to the needs of evidence-based diagnostic testing, where applicable. SOURCES: We used literature on evidence-based diagnostics, a text book on clinical trials in the development and marketing of medical devices and the English version of Regulation 2017/746 of the European Parliament and of the Council on in vitro diagnostic medical devices...
June 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29906417/selection-and-application-of-tissue-micrornas-for-non-endoscopic-diagnosis-of-barrett-s-esophagus
#4
Xiaodun Li, Sam Kleeman, Sally B Coburn, Carlo Fumagalli, Juliane Perner, Sriganesh Jammula, Ruth M Pfeiffer, Linda Orzolek, Haiping Hao, Philip R Taylor, Ahmad Miremadi, Núria Galeano-Dalmau, Pierre Lao-Sirieix, Maria Tennyson, Shona MacRae, Michael B Cook, Rebecca C Fitzgerald
BACKGROUND & AIMS: MicroRNA (miRNA) is highly stable in biospecimens and provides tissue-specific profiles, making it a useful biomarker of carcinogenesis. We aimed to discover a set of miRNAs that could accurately discriminate Barrett's esophagus (BE) from normal esophageal tissue and to test its diagnostic accuracy when applied to samples collected by a non-invasive esophageal cell sampling device. METHODS: We analyzed miRNA expression profiles of 2 independent sets of esophageal biopsy tissues collected during endoscopy from 38 patients with BE and 26 patients with normal esophagus (controls) using Agilent microarray and Nanostring counter assays...
June 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29906148/radiation-induced-chemical-dynamics-in-ar-clusters-exposed-to-strong-x-ray-pulses
#5
Yoshiaki Kumagai, Zoltan Jurek, Weiqing Xu, Hironobu Fukuzawa, Koji Motomura, Denys Iablonskyi, Kiyonobu Nagaya, Shin-Ichi Wada, Subhendu Mondal, Tetsuya Tachibana, Yuta Ito, Tsukasa Sakai, Kenji Matsunami, Toshiyuki Nishiyama, Takayuki Umemoto, Christophe Nicolas, Catalin Miron, Tadashi Togashi, Kanade Ogawa, Shigeki Owada, Kensuke Tono, Makina Yabashi, Sang-Kil Son, Beata Ziaja, Robin Santra, Kiyoshi Ueda
We show that electron and ion spectroscopy reveals the details of the oligomer formation in Ar clusters exposed to an x-ray free electron laser (XFEL) pulse, i.e., chemical dynamics triggered by x rays. With guidance from a dedicated molecular dynamics simulation tool, we find that van der Waals bonding, the oligomer formation mechanism, and charge transfer among the cluster constituents significantly affect ionization dynamics induced by an XFEL pulse of moderate fluence. Our results clearly demonstrate that XFEL pulses can be used not only to "damage and destroy" molecular assemblies but also to modify and transform their molecular structure...
June 1, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29905558/urinary-malondialdehyde-as-a-predictive-and-diagnostic-marker-for-neonatal-acute-kidney-injury
#6
Y Hodovanets, A Babintseva, L Agafonova, O Makarova, A Frunza
Newborns are especially prone to oxidative stress (OS). Many free radical-mediated diseases have been described in newborns including bronchopulmonary dysplasia, respiratory distress syndrome, encephalopathy, and kidney injury. Objective of this work was to determine predictive and diagnostic value of urinary malondialdehyde (UMDA) as a marker for acute kidney injury (AKI) in critically sick full-term newborns. 67 critically sick full-term neonates were enrolled in the study including 31 newborns with AKI (group I) and 36 newborns without AKI (group II)...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905515/diagnosis-of-primary-ciliary-dyskinesia-an-official-american-thoracic-society-clinical-practice-guideline
#7
Adam J Shapiro, Stephanie D Davis, Deepika Polineni, Michele Manion, Margaret Rosenfeld, Sharon D Dell, Mark A Chilvers, Thomas W Ferkol, Maimoona A Zariwala, Scott D Sagel, Maureen Josephson, Lucy Morgan, Ozge Yilmaz, Kenneth N Olivier, Carlos Milla, Jessica E Pittman, M Leigh Anne Daniels, Marcus Herbert Jones, Ibrahim A Janahi, Stephanie M Ware, Sam J Daniel, Matthew L Cooper, Lawrence M Nogee, Billy Anton, Tori Eastvold, Lynn Ehrne, Elena Guadagno, Michael R Knowles, Margaret W Leigh, Valery Lavergne
BACKGROUND: This document presents the American Thoracic Society clinical practice guidelines for the diagnosis of primary ciliary dyskinesia (PCD). TARGET AUDIENCE: Clinicians investigating adult and pediatric patients for possible PCD. METHODS: Systematic reviews and, when appropriate, meta-analyses were conducted to summarize all available evidence pertinent to our clinical questions. Evidence was assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach for diagnosis and discussed by a multidisciplinary panel with expertise in PCD...
June 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29904725/serum-level-of-interleukin-13-receptor-alpha-2-in-infants-with-biliary-atresia-is-it-of-value
#8
Nermin Adawy, Hanaa El-Araby, Alif Allam, Soha Elshenawy, Mohammed Khedr, Yasmine Ibrahim, Haidy M Zakaria
Aim of the study: We aimed to assess the utility of serum level IL-13Rα2 receptors as a non-invasive marker for early diagnosis of biliary atresia (BA) and selection of BA patients indicated for Kasai portoenterostomy. Material and methods: The study included 60 infants with neonatal cholestasis in three groups; early BA group ( n = 20), delayed BA group ( n = 20) and non-BA cholestasis group ( n = 20). A fourth group of 20 healthy neonates ( n = 20) served as controls...
June 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29904421/contrast-enhanced-magnetic-resonance-imaging-with-a-novel-nano-size-contrast-agent-for-the-clinical-diagnosis-of-patients-with-lung-cancer
#9
Jianwei Gao, Lei Li, Xia Liu, Rui Guo, Bin Zhao
Recent studies have indicated that magnetic resonance imaging (MRI) efficiently diagnoses lung cancer. However, the efficacy of MRI in diagnosing lung cancer requires improving for patients in the early stage of the disease. In the present study, a novel nano-sized contrast agent of chistosan/Fe3 O4 -enclosed bispecific antibodies (BsAbCENS) was introduced, which targeted carcino-embryonic antigen (CEA) and neuron-specific enolase (NSE) in lung cancer cells. The diagnostic efficacy of contrast-enhanced MRI with BsAbCENS (CEMRI-BsAbCENS) was investigated in a total of 182 patients with suspected lung cancer who had high serum levels of CEA and NSE...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29903874/assessment-of-digital-pcr-as-a-primary-reference-measurement-procedure-to-support-advances-in-precision-medicine
#10
Alexandra S Whale, Gerwyn M Jones, Jernej Pavšič, Tanja Dreo, Nicholas Redshaw, Sema Akyurek, Muslum Akgoz, Carla Divieto, Maria PaolaSassi, Hua-Jun He, Kenneth D Cole, Young-Kyung Bae, Sang-Ryoul Park, Liesbet Deprez, Philippe Corbisier, Sonia Garrigou, Valérie Taly, Raquel Larios, Simon Cowen, Denise M O'Sullivan, Claire A Bushell, Heidi Goenaga-Infante, Carole A Foy, Alison J Woolford, Helen Parkes, Jim F Huggett, Alison S Devonshire
BACKGROUND: Genetic testing of tumor tissue and circulating cell-free DNA for somatic variants guides patient treatment of many cancers. Such measurements will be fundamental in the future support of precision medicine. However, there are currently no primary reference measurement procedures available for nucleic acid quantification that would support translation of tests for circulating tumor DNA into routine use. METHODS: We assessed the accuracy of digital PCR (dPCR) for copy number quantification of a frequently occurring single-nucleotide variant in colorectal cancer ( KRAS c...
June 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29903493/a-decision-support-system-for-type-1-diabetes-mellitus-diagnostics-based-on-dual-channel-analysis-of-red-blood-cell-membrane-fluidity
#11
Ermanno Cordelli, Giuseppe Maulucci, Marco De Spirito, Alessandro Rizzi, Dario Pitocco, Paolo Soda
BACKGROUND AND OBJECTIVE: Investigation of membrane fluidity by metabolic functional imaging opens up a new and important area of translational research in type 1 diabetes mellitus, being a useful and sensitive biomarker for disease monitoring and treatment. We investigate here how data on membrane fluidity can be used for diabetes monitoring. METHODS: We present a decision support system that distinguishes between healthy subjects, type 1 diabetes mellitus patients, and type 1 diabetes mellitus patients with complications...
August 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29903489/skin-lesion-segmentation-in-dermoscopy-images-via-deep-full-resolution-convolutional-networks
#12
Mohammed A Al-Masni, Mugahed A Al-Antari, Mun-Taek Choi, Seung-Moo Han, Tae-Seong Kim
BACKGROUND AND OBJECTIVE: Automatic segmentation of skin lesions in dermoscopy images is still a challenging task due to the large shape variations and indistinct boundaries of the lesions. Accurate segmentation of skin lesions is a key prerequisite step for any computer-aided diagnostic system to recognize skin melanoma. METHODS: In this paper, we propose a novel segmentation methodology via full resolution convolutional networks (FrCN). The proposed FrCN method directly learns the full resolution features of each individual pixel of the input data without the need for pre- or post-processing operations such as artifact removal, low contrast adjustment, or further enhancement of the segmented skin lesion boundaries...
August 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29903029/a-protocol-for-a-systematic-review-of-the-diagnostic-accuracy-of-loop-mediated-isothermal-amplification-lamp-in-diagnosis-of-invasive-meningococcal-disease-in-children
#13
Thomas Waterfield, Derek Fairley, Fiona Lynn, Bronagh Blackwood, Michael D Shields
BACKGROUND: Meningococcal disease (MD) is notoriously difficult to diagnose in the early stages of the illness and presents similarly to many self-limiting viral infections. This mandates a cautious approach to diagnosis and initial management of suspected MD with many children receiving precautionary broad-spectrum intravenous antibiotics. Despite this approach, some children are still diagnosed late. In the last 10 years, there have been advances in nucleic acid amplification techniques, and there is now a rapid test that can detect meningococcal DNA in under 30 min...
June 15, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29902678/novel-urinary-biomarkers-for-the-detection-of-bladder-cancer-a-systematic-review
#14
REVIEW
Wei Shen Tan, Wei Phin Tan, Mae-Yen Tan, Pramit Khetrapal, Liqin Dong, Patricia deWinter, Andrew Feber, John D Kelly
BACKGROUND: Urinary biomarkers for the diagnosis of bladder cancer represents an area of considerable research which has been tested in both patients presenting with haematuria and non-muscle invasive bladder cancer patients requiring surveillance cystoscopy. In this systematic review, we identify and appraise the diagnostic sensitive and specificity of reported novel biomarkers of different 'omic' class and highlight promising biomarkers investigated to date. METHODS: A MEDLINE/Pubmed systematic search was performed between January 2013 and July 2017 using the following keywords: (bladder cancer OR transitional cell carcinoma OR urothelial cell carcinoma) AND (detection OR diagnosis) AND urine AND (biomarker OR assay)...
May 29, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29902633/proton-elisa-electrochemical-immunoassay-on-a-dual-gated-isfet-array
#15
Duane S Juang, Ching-Hui Lin, Yi-Ren Huo, Chia-Yu Tang, Chun-Ren Cheng, Hua-Shu Wu, Shih-Fen Huang, Alexander Kalnitsky, Chun-Cheng Lin
Here we report an electrochemical immunoassay platform called Proton-ELISA (H-ELISA) for the detection of bioanalytes. H-ELISA uniquely utilizes protons as an immunoassay detection medium, generated by the enzyme glucose oxidase (GOx) coupled with Fenton's reagent in a proton amplification reaction cascade that results in a highly amplified signal. A proton-sensitive dual-gated ion-sensitive field effect transistor (DG-ISFET) sensor was also developed for sensitive and accurate detection of the proton signal in H-ELISA...
June 7, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29902075/the-diagnostic-value-of-combining-conventional-diffusion-weighted-imaging-and-dynamic-contrast-enhanced-mri-for-salivary-gland-tumors
#16
Ning Zheng, Rui Li, Wenjuan Liu, Shuo Shao, Shan Jiang
OBJECTIVES: To determine the diagnostic value of combining conventional MRI, diffusion-weighted (DWI) and dynamic contrast enhanced MRI (DCE-MRI) in salivary gland tumors. METHODS: Forty-five patients with salivary gland tumors were evaluated with conventional MRI, DWI and DCE-MRI prior to surgery and confirmed by pathologic findings. The apparent diffusion coefficient (ADC) was calculated from DWI that was obtained with a factor of 0 and 1000 s/mm2 . A time-intensity curve (TIC) was obtained from DCE-MRI...
June 14, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29901627/comparison-of-endoscopic-ultrasound-guided-fine-needle-aspiration-and-biopsy-with-22-gauge-and-25-gauge-needles-for-the-precision-medicine-of-pancreatic-cancer-a-retrospective-study
#17
Naohiko Yoshizawa, Reiko Yamada, Takashi Sakuno, Hiroyuki Inoue, Hiroshi Miura, Toshifumi Takeuchi, Misaki Nakamura, Yasuhiko Hamada, Masaki Katsurahara, Kyosuke Tanaka, Noriyuki Horiki, Yoshiyuki Takei
We compared the sample volume of endoscopic ultrasound-guided fine-needle aspiration and biopsy (EUS-FNAB) specimens obtained by 22-gauge (22G) and 25-gauge (25G) needles, and the accuracy rate.This was a retrospective study in a single tertiary referral center. We investigated 153 patients with pancreatic ductal adenocarcinoma (PDAC) who underwent diagnostic EUS-FNAB before neoadjuvant gemcitabine-based chemoradiotherapy between October 2006 and November 2015. We performed immunohistochemical (IHC) analysis of human equilibrative nucleoside transporter 1 using the remnant cell blocks following pathological PDAC diagnosis...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901579/electrocardiogram-criteria-of-limb-leads-predicting-right-coronary-artery-as-culprit-artery-in-inferior-wall-myocardial-infarction-a-meta-analysis
#18
Hao Liang, Lan Wu, Yingchen Li, Yidi Zeng, Zhixi Hu, Xinchun Li, Xiang Sun, Qiuyan Zhang, Xiaoqing Zhou
BACKGROUND: Prior studies have proposed several electrocardiogram (ECG) criteria in limb leads for identifying the culprit coronary artery (CCA) in patients with acute inferior wall myocardial infarction (IWMI). The aim of our study was to conduct an evidence-based evaluation and test accuracy comparison of these criteria. METHODS: We searched the PubMed, Embase, and Ovid. Eligible studies to assess the diagnostic performance of ECG criteria predicting CCA in IWMI were reviewed for inclusion...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901532/sampling-utility-of-the-convex-probe-endobronchial-ultrasound-visible-intrapulmonary-lesion
#19
Francisco A Almeida, Shameen Salam, Atul C Mehta, Luke Yuhico, Yash Sarda, Humberto Choi, Joseph C Cicenia, Thomas Gildea, Michael Machuzak, Peter Mazzone, Eduardo Oliveira, Sonali Sethi, Xiao-Feng Wang, Jordan P Reynolds
BACKGROUND: The value of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the mediastinal staging of lung cancer has been well established. However, data regarding its utility in the diagnosis of intrapulmonary lesions has been sparse. This study assesses the sampling utility of convex probe EBUS-visible intrapulmonary lesions not visualized by the white-light bronchoscopy. METHODS: A retrospective analysis of EBUS-TBNA of EBUS-visible intrapulmonary lesions was performed between January 2010 and March 2015...
June 12, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29901465/diagnostic-accuracy-of-inferior-vena-caval-respiratory-variation-in-detecting-fluid-unresponsiveness-a-systematic-review-and-meta-analysis
#20
Saurabh K Das, Nang S Choupoo, Debasis Pradhan, Priyam Saikia, Xavier Monnet
BACKGROUND: The accuracy of respiratory variation of the inferior vena cava (rvIVC) in predicting fluid responsiveness, particularly in spontaneously breathing patients is unclear. OBJECTIVES: To consider the evidence to support the accuracy of rvIVC in identifying patients who are unlikely to benefit from fluid administration. DESIGN: Systematic review and meta-analysis. DATA SOURCE: We searched MEDLINE, EMBASE, Cochrane Library, KoreaMed, LILCAS and WHO Clinical Trial Registry from inception to June 2017...
June 12, 2018: European Journal of Anaesthesiology
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