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Vitamin A toxic

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https://www.readbyqxmd.com/read/27912044/mutations-in-prosc-disrupt-cellular-pyridoxal-phosphate-homeostasis-and-cause-vitamin-b6-dependent-epilepsy
#1
Niklas Darin, Emma Reid, Laurence Prunetti, Lena Samuelsson, Ralf A Husain, Matthew Wilson, Basma El Yacoubi, Emma Footitt, W K Chong, Louise C Wilson, Helen Prunty, Simon Pope, Simon Heales, Karine Lascelles, Mike Champion, Evangeline Wassmer, Pierangelo Veggiotti, Valérie de Crécy-Lagard, Philippa B Mills, Peter T Clayton
Pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, functions as a cofactor in humans for more than 140 enzymes, many of which are involved in neurotransmitter synthesis and degradation. A deficiency of PLP can present, therefore, as seizures and other symptoms that are treatable with PLP and/or pyridoxine. Deficiency of PLP in the brain can be caused by inborn errors affecting B6 vitamer metabolism or by inactivation of PLP, which can occur when compounds accumulate as a result of inborn errors of other pathways or when small molecules are ingested...
December 1, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27909615/the-histopathological-evaluation-of-healing-effects-of-vitamin-c-administered-before-methotrexate-therapy-on-testicular-injury-induced-by-methotrexate
#2
Aysun Sayılmaz, Yasemin Yuyucu Karabulut, Aydan Özgörgülü
OBJECTIVE: Methotrexate (MTX) leads to acute toxic side effects in tissues or organs containing rapidly dividing cells such as seminiferous tubules. In this study, we investigated the protective effects of vitamin C against MTX-induced injury in rat testis. MATERIAL AND METHODS: A total of 31 rats were divided into 4 groups, including the control group. The study was completed within 4 weeks and the rats received daily doses of 2 mL/kg SF, 100 mg/kg vitamin C and 10 mg/kg/day MTX i...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27903519/dairy-intake-and-fecundability-in-2-preconception-cohort-studies
#3
Lauren A Wise, Amelia K Wesselink, Ellen M Mikkelsen, Heidi Cueto, Kristen A Hahn, Kenneth J Rothman, Katherine L Tucker, Henrik Toft Sørensen, Elizabeth E Hatch
BACKGROUND: Animal studies have shown that a high intake of galactose, a breakdown product of lactose, increases ovarian toxicity. Few epidemiologic studies, to our knowledge, have examined the association between dairy intake and fertility, and they have had conflicting findings. OBJECTIVE: We prospectively evaluated dairy intake in relation to fecundability among women who were planning for pregnancy. DESIGN: Data were derived from preconception cohort studies in Denmark (Snart Foraeldre) and North America [PRESTO (Pregnancy Study Online)] in which women completed a validated food-frequency questionnaire 10 d after enrollment...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27893995/combined-effects-of-cadmium-temperature-and-hypoxia-reoxygenation-on-mitochondrial-function-in-rainbow-trout-oncorhynchus-mykiss
#4
John O Onukwufor, Don Stevens, Collins Kamunde
Although aquatic organisms face multiple environmental stressors that may interact to alter adverse outcomes, our knowledge of stressor-stressor interaction on cellular function is limited. We investigated the combined effects of cadmium (Cd), hypoxia-reoxygenation (H-R) and temperature on mitochondrial function. Liver mitochondria from juvenile rainbow trout were exposed to Cd (0-20μM) and H-R (0 and 5min) at 5, 13 and 25°C followed by measurements of mitochondrial Cd load, volume, complex І active (A)↔deactive (D) transition, membrane potential, ROS release and ultrastructural changes...
November 18, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27892893/photoprotective-and-radioprotective-properties-of-nitroxides-and-their-application-in-magnetic-resonance-imaging
#5
Marcin Lewandowski, Krzysztof Gwoździński
Nitroxides are a group of stable organic radicals of low molecular weight having a nitroxyl group > N-.O, which has an unpaired electron. The presence of this group allows a nitroxide to participate in redox reactions. They serve as mimics of superoxide dismutase (SOD) and have stimulative properties towards haemoproteins with catalase-like activity. Nitroxides oxidize Fe (II) to Fe (III) preventing the Fenton and Haber-Weiss reactions. As the radicals have the ability to scavenge other free radicals. Nitroxides are not immunogenic, and mutagenic and do not show toxicity to the human cells...
October 14, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27889885/investigating-factors-involved-in-post-laparoscopic-sleeve-gastrectomy-lsg-neuropathy
#6
Almaha Alsabah, Salman Al Sabah, Suleiman Al-Sabah, Ahmad Al-Serri, Eliana Al Haddad, Waleed M Renno
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has gained popularity as the leading bariatric procedure for the treatment of morbid obesity. Due to the rising numbers of bariatric surgeries, neurologic complications have become increasingly recognized. Our aim was to examine biochemical and hormonal factors that are associated with neuropathy post-LSG. METHODS: Thirty-two patients were included: 16 patients with neuropathy in the neuropathic group (NG) and 16 patients without neuropathy in the control group (CG)...
November 26, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27882116/in-vitro-and-in-vivo-assessment-of-high-dose-vitamin-c-against-murine-tumors
#7
Guoping Wang, Tao Yin, Yongsheng Wang
Vitamin C is widely used in clinical settings and is well known for its safety. Previous studies have shown the efficacy of intravenous vitamin C; however, intratumoral delivery of vitamin C has yet to be attempted. In the present study, the biological effects of high-dose vitamin C on tumor cells were investigated in vitro by using the MTT assay and flow cytometry. When administered in vitro, high-dose vitamin C inhibited the proliferation of murine colon and breast cancer cells, and induced tumor cell apoptosis...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27879469/frequency-of-common-vkorc1-polymorphisms-and-their-impact-on-warfarin-dose-requirement-in-pakistani-population
#8
Aisha Qayyum, Muzammil Hasan Najmi, Qaisar Mansoor, Muhammad Irfan, Abdul Khaliq Naveed, Andleeb Hanif, Ali Raza Kazmi, Muhammad Ismail
Polymorphisms in vitamin K epoxide reductase complex subunit 1 (VKORC1) gene lead to interindividual variability in warfarin dose requirement. The characterization of genotype frequency distribution is required in different populations for construction of customized dosing algorithms to enhance the efficacy and reduce the toxicity of warfarin therapy. This study was carried out in Pakistani population to evaluate the contribution of common VKORC1 polymorphisms to warfarin therapy. A total of 550 stable patients taking warfarin were enrolled after medical history, physical examination, and laboratory investigations...
November 21, 2016: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27869747/the-vitamin-e-analog-gamma-tocotrienol-gt3-and-statins-synergistically-up-regulate-endothelial-thrombomodulin-tm
#9
Rupak Pathak, Sanchita P Ghosh, Daohong Zhou, Martin Hauer-Jensen
Statins; a class of routinely prescribed cholesterol-lowering drugs; inhibit 3-hydroxy-3-methylglutaryl-coenzymeA reductase (HMGCR) and strongly induce endothelial thrombomodulin (TM); which is known to have anti-inflammatory; anti-coagulation; anti-oxidant; and radioprotective properties. However; high-dose toxicity limits the clinical use of statins. The vitamin E family member gamma-tocotrienol (GT3) also suppresses HMGCR activity and induces TM expression without causing significant adverse side effects; even at high concentrations...
November 18, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27863301/antioxidant-and-anticancer-effects-and-bioavailability-studies-of-the-flavonoid-baicalin-and-its-oxidovanadium-iv-complex
#10
Juan J Martínez Medina, Luciana G Naso, Ana L Pérez, Alberto Rizzi, Evelina G Ferrer, Patricia A M Williams
Based on the known antioxidant effect of flavonoids, baicalin (baic) found in roots of Scutellaria has been selected. Its coordination complex with the oxidovanadium(IV) cation, Na4[VO(baic)2].6H2O (V(IV)O(baic)), was synthesized at pH9 in ethanol and characterized by physicochemical methods. Spectrophotometric studies at pH9 showed a ligand: metal stoichiometry of 2:1. By vibrational spectroscopy a coordination mode through the cis 5-OH and 6-OH deprotonated groups is inferred. EPR spectroscopy shows an environment of four aryloxide (ArO(-)) groups in the equatorial plane of the VO moiety, both in solution and in the solid complex...
November 5, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27862983/denosumab-prevention-and-management-of-hypocalcemia-osteonecrosis-of-the-jaw-and-atypical-fractures
#11
REVIEW
Kenneth Pittman, Yoland C Antill, Amanda Goldrick, Jeffrey Goh, Richard H de Boer
Denosumab, a bone-modifying agent, reduces the risk of skeletal-related events in patients with bone metastases from solid tumors and is generally well tolerated. However, hypocalcemia, osteonecrosis of the jaw (ONJ) and atypical fracture are potential and important toxicities of denosumab therapy that require attention. In pivotal phase III trials in patients with bone metastases from solid tumors, the incidence of hypocalcemia was 9.6% in denosumab-treated patients, with most events being asymptomatic, grade 2 and resolving by week 4...
November 10, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27845199/in-vitro-toxicity-of-pirimiphos-methyl-in-atlantic-salmon-hepatocytes
#12
Pål A Olsvik, Marc H G Berntssen, Liv Søfteland
Recent screening of Atlantic salmon feeds has uncovered residues of several pesticides, including pirimiphos-methyl. Pirimiphos-methyl is an organophosphate (OP) insecticide, causing inhibition of acetylcholinesterase in target organisms. The aim of this study was to examine pirimiphos-methyl non-targeted mode of action toxicity in Atlantic salmon using in vitro exposure. Hepatocyte cells were exposed to pirimiphos-methyl (control-0.1-1.0-10-100-1000μM) for 48h. Transcriptomics (RNA-seq) and non-targeted metabolomics were used to screen for effects of the pesticide...
November 12, 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/27830507/vitamin-a-and-vision
#13
John C Saari
Visual systems detect light by monitoring the effect of photoisomerization of a chromophore on the release of a neurotransmitter from sensory neurons, known as rod and cone photoreceptor cells in vertebrate retina. In all known visual systems, the chromophore is 11-cis-retinal complexed with a protein, called opsin, and photoisomerization produces all-trans-retinal. In mammals, regeneration of 11-cis-retinal following photoisomerization occurs by a thermally driven isomerization reaction. Additional reactions are required during regeneration to protect cells from the toxicity of aldehyde forms of vitamin A that are essential to the visual process...
2016: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/27821044/comparative-transcriptome-profiling-of-two-brassica-napus-cultivars-under-chromium-toxicity-and-its-alleviation-by-reduced-glutathione
#14
Rafaqat A Gill, Basharat Ali, Peng Cui, Enhui Shen, Muhammad A Farooq, Faisal Islam, Shafaqat Ali, Bizeng Mao, Weijun Zhou
BACKGROUND: Chromium (Cr) being multifarious industrial used element, is considered a potential environmental threat. Cr found to be a prospective water and soil pollutant, and thus it is a current area of concern. Oilseed rape (Brassica napus L.) is well known as a major source of edible oil around the globe. Due to its higher growth, larger biomass and capability to uptake toxic materials B. napus is considered a potential candidate plant against unfavorable conditions. To date, no study has been done that described the Cr and GSH mechanism at RNA-Seq level...
November 7, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27818732/evaluation-of-some-biochemical-parameters-and-brain-oxidative-stress-in-experimental-rats-exposed-chronically-to-silver-nitrate-and-the-protective-role-of-vitamin-e-and-selenium
#15
Mouna Gueroui, Zine Kechrid
Due to undesirable hazardous interactions with biological systems, this investigation was undertaken to evaluate the effect of chronic exposure to silver on certain biochemical and some oxidative stress parameters with histopathological examination of brain, as well as the possible protective role of selenium and/or vitamin E as nutritional supplements. Thirty six male rats were divided into six groups of six each: the first group used as a control group. Group II given both vitamin E (400 mg/kg) of diet and selenium (Se) (1 mg/L) in their drinking water...
October 2016: Toxicological Research
https://www.readbyqxmd.com/read/27818322/an-overview-of-herb-and-dietary-supplement-efficacy-safety-and-government-regulations-in-the-united-states-with-suggested-improvements-part-1-of-5-series
#16
REVIEW
Amy Christine Brown
This is the first of five review articles investigating dietary supplements (DS; includes herbs) that now exceed over 50,000 in the Office of Dietary Supplement's "Dietary Supplement Label Database." Four review articles follow summarizing published medical case reports of DS related to liver toxicity, kidney toxicity, heart toxicity, and cancer. The most popular DS were vitamin or mineral supplements (43%) followed by specialty supplements (20%), botanicals (herbs; 20%), and sports supplements (16%). The 2013 Annual Report of the American Association of Poison Control Centers revealed 1692 fatalities due to drugs and zero deaths due to DS...
November 3, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27816611/vitamin-e-emerging-aspects-and-new-directions
#17
REVIEW
Francesco Galli, Angelo Azzi, Marc Birringer, Joan M Cook-Mills, Manfred Eggersdorfer, Jan Frank, Gabriele Cruciani, Stefan Lorkowski, Nesrin Kartal Özer
The discovery of vitamin E will have its 100th anniversary in 2022, but we still have more questions than answers regarding the biological functions and the essentiality of vitamin E for human health. Discovered as a factor essential for rat fertility and soon after characterized for its properties of fat-soluble antioxidant, vitamin E was identified to have signaling and gene regulation effects in the 1980s. In the same years the cytochrome P-450 dependent metabolism of vitamin E was characterized and a first series of studies on short-chain carboxyethyl metabolites in the 1990s paved the way to the hypothesis of a biological role for this metabolism alternative to vitamin E catabolism...
November 2, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27790858/epidemiology-of-complementary-and-alternative-medicine-therapy-use-in-allogeneic-hematopoietic-stem-cell-transplant-survivorship-patients-in-australia
#18
Julian Lindsay, Masrura Kabir, Nicole Gilroy, Gemma Dyer, Lisa Brice, John Moore, Matthew Greenwood, Mark Hertzberg, David Gottlieb, Stephen R Larsen, Megan Hogg, Louisa Brown, Gillian Huang, Jeff Tan, Christopher Ward, Ian Kerridge
In addition to prescribed conventional medicines, many allogeneic hematopoietic stem cell transplant (HSCT) survivors also use complementary and alternative medical therapies (CAM), however, the frequency and types of CAMs used by allogeneic HSCT survivors remain unclear. Study participants were adults who had undergone an allogeneic HSCT between 1st January 2000 and 31st December 2012. Participants completed a 402-item questionnaire regarding the use of CAM, medical complications, specialist referrals, medications and therapies, infections, vaccinations, cancer screening, lifestyle, and occupational issues and relationship status following stem cell transplantation...
October 27, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27784232/melissa-of%C3%AF-cinalis-and-vitamin-e-as-the-potential-therapeutic-candidates-for-reproductive-toxicity-caused-by-anti-cancer-drug-cisplatin-in-male-rats
#19
Maryam Iman, Mostafa Araghi, Toktam Heidari, Vahid Mohammadi
BACKGROUND: High doses of Cisplatin (CP) can disrupt the normal function of various tissues such as ovaries and testis. In almost all the patients, spermiotoxicity of CP causes temporary or permanent azoospermia. OBJECTIVE: In this study, the defensive effect of Melissa officinalis and vitamin E against testicular injuries caused by CP in male rats was evaluated. METHOD: Thirty six male rats were distributed into 6 groups. Group 1 used as the negative control...
October 26, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27783938/vitamin-d-promotes-protein-homeostasis-and-longevity-via-the-stress-response-pathway-genes-skn-1-ire-1-and-xbp-1
#20
Karla A Mark, Kathleen J Dumas, Dipa Bhaumik, Birgit Schilling, Sonnet Davis, Tal Ronnen Oron, Dylan J Sorensen, Mark Lucanic, Rachel B Brem, Simon Melov, Arvind Ramanathan, Bradford W Gibson, Gordon J Lithgow
Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an increased risk of age-related chronic diseases, including Alzheimer's disease, Parkinson's disease, cognitive impairment, and cancer. In this study, we utilized Caenorhabditis elegans to examine the mechanism by which vitamin D influences aging. We found that vitamin-D3-induced lifespan extension requires the stress response pathway genes skn-1, ire-1, and xbp-1...
October 25, 2016: Cell Reports
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