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Vitamin A toxic

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https://www.readbyqxmd.com/read/29149414/role-of-tctp-for-cellular-differentiation-and-cancer-therapy
#1
Ean-Jeong Seo, Nicolas Fischer, Thomas Efferth
The translationally controlled tumor protein (TCTP) is a highly conserved protein that is regulated due to a high number of extracellular stimuli. TCTP has an important role for cell cycle and normal development. On the other side, tumor reversion and malignant transformation have been associated with TCTP. TCTP has been found among the 12 genes that are differentially expressed during mouse oocyte maturation, and an overexpression of this gene was reported in a wide variety of different cancer types. Its antiapoptotic effect is indicated by the interaction with several proapoptotic proteins of the Bcl-2 family and the p53 tumor suppressor protein...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/29137047/massive-neonatal-intracranial-hemorrhage-caused-by-bromadiolone-a-case-report
#2
Mingsheng Ma, Mengqi Zhang, Xiaoyan Tang, Zhenghong Li
RATIONALE: Bromadiolone, often called a super-warfarin, is a potent rodenticide with long half-life. Skin and mucosal bleeding is the most common clinical manifestations of its intoxication. Bromadiolone intoxications in adults and children have been reported, but this phenomenon is rarely seen in fetuses. This paper presents a case of neonate with massive intracranial hemorrhage mediated by bromadiolone intoxication, highlighting that the bromadiolone is potentially lethal to the fetus...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29122613/hemin-and-myoglobin-catalyzed-reaction-of-1-palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine-13-hydroperoxide-with-%C3%AE-tocopherol-in-micelles-and-liposomes
#3
Ryo Yamauchi, Tomomi Kinoshita, Yoshinori Hasegawa, Satoshi Iwamoto
The secondary process of lipid peroxidation proceeds by the free radical reaction to produce some toxic aldehydes. Since γ-tocopherol (γ-TH), one of the major forms of vitamin E in some vegetable oils, acts as a free radical scavenger, γ-TH may suppress the formation of such aldehydes. This study reports the effect and reaction products of γ-TH on the hemin- or myoglobin-catalyzed decomposition of 1-palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine 13-hydroperoxide (PLPC-OOH) in micelles and liposomes. γ-TH and PLPC-OOH in micelles were reacted in the presence of hemin, and the reaction products were characterized as 1-palmitoyl-2-[(8a-dioxy-γ-tocopherone)-12,13-epoxyoctadecenoyl]-3-sn-phosphatidylcholines (γT-OO-epoxyPLPC), 1-palmitoyl-2-[(γ-tocopheroxy)-12,13-epoxyoctadecenoyl]-3-sn-phosphatidylcholines (γT-epoxyPLPC), and the adducts of γ-TH dimer with PLPC-OOH derived epoxyperoxyl and epoxyalkyl radicals (γTD-OO-epoxyPLPC and γTD-epoxyPLPC)...
November 7, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29120005/peripheral-neuropathy-due-to-recreational-use-of-nitrous-oxide-presenting-after-an-ankle-sprain-with-foot-drop
#4
Jackson A Middleton, John A Roffers
A 22-year-old man was referred for orthopedic follow-up after an ankle injury. Initial evaluation in urgent care included radiographs with negative findings. After a delayed presentation, a course of functional treatment was recommended. Subsequently, he developed a deep venous thrombosis and pulmonary emboli. He was found to be factor V Leiden deficient and was fully anticoagulated on warfarin. Later reevaluation revealed a steppage gait and foot drop. Electrodiagnostic studies (ie, electromyography and nerve conduction studies) revealed a severe peripheral polyneuropathy...
November 8, 2017: Orthopedics
https://www.readbyqxmd.com/read/29108440/cardiopreventive-effects-of-camel-milk-against-carbon-tetrachloride-induced-oxidative-stress-biochemical-and-histological-alterations-in-mice
#5
Houda Hamed, Manel Gargouri, Khaled Bellassoued, Zied Ghannoudi, Abdelfattah Elfeki, Ahmed Gargouri
The present study was designed to examine the preventive effects of camel milk (CM) against the toxic effects of acute exposure to carbon tetrachloride (CCl4) on the heart tissue of mice. Administration of a single dose of CCl4 caused cardio toxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances), protein carbonyl level and antioxidant markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione and vitamin C) in the heart tissue. Moreover, CCl4 caused a distinguished rise of plasma aspartate aminotransferase, lactate dehydrogenase, troponin I, and creatine kinase activities...
November 6, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29106434/nanoprodrug-of-retinoic-acid-modified-paclitaxel
#6
Zijun Zhou, Jingzhe Yan, Tingting Sun, Xin Wang, Zhigang Xie
All-trans-retinoic acid (RA) is a non-toxic physiological metabolite of vitamin A. A paclitaxel (PTX) prodrug (RA-PTX) with high PTX content of 75% was synthesized via an easy condensation reaction. RA-PTX nanoparticles (RA-PTX NPs) were prepared through a nanoprecipitation method which increased the water solubility of PTX. RA-PTX NPs were spherical in shape and exhibited favorable structural stability in both water and the physiological environment. RA-PTX NPs possessed effective cellular uptake as revealed by confocal laser scanning microscopy and exerted potent cytotoxicity...
November 6, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29104938/vitamin-and-amino-acid-auxotrophy-in-anaerobic-consortia-operating-under-methanogenic-conditions
#7
Valerie Hubalek, Moritz Buck, BoonFei Tan, Julia Foght, Annelie Wendeberg, David Berry, Stefan Bertilsson, Alexander Eiler
Syntrophy among Archaea and Bacteria facilitates the anaerobic degradation of organic compounds to CH4 and CO2. Particularly during aliphatic and aromatic hydrocarbon mineralization, as in the case of crude oil reservoirs and petroleum-contaminated sediments, metabolic interactions between obligate mutualistic microbial partners are of central importance. Using micromanipulation combined with shotgun metagenomic approaches, we describe the genomes of complex consortia within short-chain alkane-degrading cultures operating under methanogenic conditions...
September 2017: MSystems
https://www.readbyqxmd.com/read/29102624/antitumoral-effects-of-the-alkynylphosphonate-analogue-of-calcitriol-em1-on-glioblastoma-multiforme-cells
#8
María Julia Ferronato, Eliana Noelia Alonso, Débora Gisele Salomón, María Eugenia Fermento, Norberto Ariel Gandini, Mario Alfredo Quevedo, Evangelina Mascaró, Cristian Vitale, Yagamare Fall, María Marta Facchinetti, Alejandro Carlos Curino
Glioblastoma multiforme (GBM) is the worst and most common brain tumor, characterized by high proliferation and invasion rates. The current standard treatment is mainly based on chemoradiotherapy and this approach has slightly improved patient survival. Thus, novel strategies aimed at prolonging the survival and ensuring a better quality of life are necessary. In the present work, we investigated the antitumoral effect of the novel analogue of calcitriol EM1 on GBM cells employing in vitro, in silico, and in vivo assays...
November 1, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29100878/n-acetyl-l-cysteine-and-mn-2-attenuate-cd-2-induced-disturbance-of-the-intracellular-free-calcium-homeostasis-in-cultured-cerebellar-granule-neurons
#9
Nickolay K Isaev, Svetlana Avilkina, Sergey A Golyshev, Elisaveta E Genrikhs, Olga P Alexandrova, Marina R Kapkaeva, Elena V Stelmashook
Cadmium is a highly toxic heavy metal that is capable of accumulating in the body via direct exposure or through the alimentary and respiratory tract, leading to neurodegeneration. In this article, we show that the application of CdCl2 (0.001-0.005mM) for 48h induced high dose-dependent death rate of cultured cerebellar granule neurons (CGNs). Unlike Trolox or vitamin E, antioxidant N-acetyl-l-cysteine (NAC, 1mM) and Mn(2+) (0.0025-0.005mM) significantly protected CGNs from this toxic effect. Using Fluo-4 AM, measurements of intracellular calcium ions demonstrated that 24h-exposure to Cd(2+) induced intensive increase of Fluo-4 fluorescence in neurons accompanied by mitochondria swelling...
October 31, 2017: Toxicology
https://www.readbyqxmd.com/read/29094039/host-directed-therapeutic-strategies-for-tuberculosis
#10
REVIEW
Afsal Kolloli, Selvakumar Subbian
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of morbidity and mortality in humans worldwide. Currently, the standard treatment for TB involves multiple antibiotics administered for at least 6 months. Although multiple antibiotics therapy is necessary to prevent the development of drug resistance, the prolonged duration of treatment, combined with toxicity of drugs, contributes to patient non-compliance that can leads to the development of drug-resistant Mtb (MDR and XDR) strains...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29092993/the-effect-of-a-single-early-high-dose-vitamin-d-supplement-on-fracture-union-in-patients-with-hypovitaminosis-d-a-prospective-randomised-trial
#11
N Haines, L B Kempton, R B Seymour, M J Bosse, C Churchill, K Hand, J R Hsu, D Keil, J Kellam, N Rozario, S Sims, M A Karunakar
AIMS: To evaluate the effect of a single early high-dose vitamin D supplement on fracture union in patients with hypovitaminosis D and a long bone fracture. PATIENTS AND METHODS: Between July 2011 and August 2013, 113 adults with a long bone fracture were enrolled in a prospective randomised double-blind placebo-controlled trial. Their serum vitamin D levels were measured and a total of 100 patients were found to be vitamin D deficient (< 20 ng/ml) or insufficient (< 30 ng/mL)...
November 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29092737/oxalate-nephropathy-following-vitamin-c-intake-within-intensive-care-unit%C3%A2
#12
Eloïse Colliou, Arnaud Mari, Audrey Delas, Antoine Delarche, Stanislas Faguer
OBJECTIVE: To report a case of acute oxalate nephropathy related to vitamin C intake within the intensive care unit (ICU). DESIGN: Case report. SETTING: ICU and nephrology department of a French university hospital. PATIENT: A 57-year-old woman with septic shock related to Legionella pneumophila pneumonia complicated by acute respiratory distress syndrome and acute kidney injury who required renal replacement therapy for 75 days...
October 26, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29091903/chemoprotective-role-of-ethanol-extract-of-urtica-urens-l-against-the-toxicity-of-imidacloprid-on-endocrine-disruption-and-ovarian-morphometric-in-female-rats-gc-ms-analysis
#13
Massara Mzid, Zohra Ghlissi, Maryem Ben Salem, Sameh Ben Khedir, Khansa Chaabouni, Fatma Ayedi, Zouheir Sahnoun, Ahmed Hakim, Tarek Rebai
Imidacloprid (IMI) is a widely used in Tunisia and abroad, and high doses of IMI have been known to cause endocrine disruption. Some reports claim that Urtica urens L. (UU) can reduce toxicity thanks to it anti-inflammatory and antioxidant activities, but there is no scientific evidence justifying its use, which lets us think to its direct effect on the metabolism of the ovarian tissue. The present study was undertaken to evaluate the protective effect of UU against the toxicity of Confidor(®), whose active substance is imidacloprid (IMI), in female rat, as well as the chemical compositions of UU ethanol (EtOH) extract by GC-MS...
October 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29080450/beneficial-effects-of-fermented-camel-milk-by-lactococcus-lactis-subsp-cremoris-on-cardiotoxicity-induced-by-carbon-tetrachloride-in-mice
#14
Houda Hamed, Fatma Chaari, Zied Ghannoudi, Abdelfattah ElFeki, Semia Chaabouni Ellouz, Ahmed Gargouri
Carbon tetrachloride (CCl4) is a xenobiotic present in the environment, can cause harmful effects on human health. In the present study, we attempted to elucidate the cardiopreventive potential of the fermented camel milk by lactococcus lactis subsp cremoris (FCM-LLC) against the toxic effects of acute exposure to CCl4 on heart tissue of mice. Twenty-eight mice's were divided into four groups of seven each: group (C) served as control; group (FCM-LLC) received only 100mgL of FCM-LLC/kg body weight daily for 15days; group (CCl4) was administered by a single dose of CCl4 (10mL/kg in 0...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29080344/bile-acids-and-cancer-direct-and-environmental-dependent-effects
#15
Agostino Di Ciaula, David Q-H Wang, Emilio Molina-Molina, Raquel Lunardi Baccetto, Giuseppe Calamita, Vincenzo O Palmieri, Piero Portincasa
Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but have also a key role as singalling molecules and in the modulation of epithelial cell proliferation, gene expression and metabolism. These homeostatic pathways, when disrupted, are able to promote local inflammation, systemic metabolic disorders and, ultimately, cancer. The effect of hydrophobic BAs, in particular, can be linked with cancer in several digestive (mainly oesophagus, stomach, liver, pancreas, biliary tract, colon) and extra-digestive organs (i...
October 28, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/29076678/vitamin-d-toxicity-and-other-non-malignant-causes-of-hypercalcemia-a-retrospective-study-at-a-tertiary-care-hospital-in-pakistan
#16
Muhammad Naeem Khan, Muhammad Qamar Masood, Mohammad Arsalan Siddiqui, Sabahat Naz, Najmul Islam
BACKGROUND: Hypercalcemia is a common clinical problem; primary hyperparathyroidism and malignancy is commonest causes of hypercalcemia. Aetiology of hypercalcemia are changing, causes that were diseases of the past like Vitamin-D toxicity and milk alkali syndrome are observed more often. Vitamin-D deficiency is an important problem and overzealous replacement of Vitamin-D has been observed, suspected to cause toxicity. METHODS: This was a retrospective review of patients admitted at the Aga Khan University Hospital from January 2008 to December 2013 with hypercalcemia...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29072525/evaluation-of-epigallocatechin-gallate-and-epicatechin-gallate-effects-on-acrylamide-induced-neurotoxicity-in-rats-and-cytotoxicity-in-pc-12-cells
#17
Elahe Esmaeelpanah, Bibi Marjan Razavi, Faezeh Vahdati Hasani, Hossein Hosseinzadeh
The neurotoxicity of acrylamide (ACR) monomer occurs through different mechanisms such as oxidative stress. Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) are green tea catechins which are known as powerful antioxidants. In this study, we examined the possible protective effects of ECG and EGCG on ACR neurotoxicity in both in-vitro and in-vivo models. PC12 cells were exposed to different concentrations of ECG and EGCG. After 24 and 48 hours, ACR was added to the cells (IC50 = 4.85 mM) and cell viability was measured through MTT assay after 24 hours...
October 26, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29070711/dietary-b-vitamin-intake-is-associated-with-lower-urinary-monomethyl-arsenic-and-oxidative-stress-marker-15-f2t-isoprostane-among-new-hampshire-adults
#18
Caitlin G Howe, Zhigang Li, Michael S Zens, Thomas Palys, Yu Chen, Jacqueline Y Channon, Margaret R Karagas, Shohreh F Farzan
Background: Arsenic exposure has been associated with an increased risk of cardiovascular disease (CVD). Growing evidence suggests that B vitamins facilitate arsenic metabolism and may protect against arsenic toxicity. However, to our knowledge, few studies have evaluated this in US populations.Objective: Our objective was to examine whether higher B vitamin intake is associated with enhanced arsenic metabolism and lower concentrations of preclinical markers of CVD among New Hampshire adults.Methods: We used weighted quantile sum (WQS) regression to evaluate the collective impact of 6 dietary B vitamins (thiamin, riboflavin, folate, niacin, and vitamins B-6 and B-12) on 1) the proportion of arsenic metabolites in urine and 2) 6 CVD-related markers [including urinary 15-F2t-isoprostane (15-F2t-IsoP)] among 418 participants (26-75 y of age) from the New Hampshire Health Study...
October 25, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/29069637/redox-active-metals-and-h2o2-mediate-the-increased-efficacy-of-pharmacological-ascorbate-in-combination-with-gemcitabine-or-radiation-in-pre-clinical-sarcoma-models
#19
Joshua D Schoenfeld, Zita A Sibenaller, Kranti A Mapuskar, Megan D Bradley, Brett A Wagner, Garry R Buettner, Varun Monga, Mohammed Milhem, Douglas R Spitz, Bryan G Allen
Soft tissue sarcomas are a histologically heterogeneous group of rare mesenchymal cancers for which treatment options leading to increased overall survival have not improved in over two decades. The current study shows that pharmacological ascorbate (systemic high dose vitamin C achieving ≥ 20mM plasma levels) is a potentially efficacious and easily integrable addition to current standard of care treatment strategies in preclinical models of fibrosarcoma and liposarcoma both in vitro and in vivo. Furthermore, enhanced ascorbate-mediated toxicity and DNA damage in these sarcoma models were found to be dependent upon H2O2 and intracellular labile iron...
September 28, 2017: Redox Biology
https://www.readbyqxmd.com/read/29068590/vitamin-e-%C3%AE-tocopherol-attenuates-toxicity-and-oxidative-stress-induced-by-aflatoxin-in-rats
#20
Seval Yılmaz, Emre Kaya, Selim Comakli
BACKGROUND: Aflatoxins are toxic metabolites produced by Aspergillus flavus and Aspergillus parasiticus and are classified as group I carcinogens by the International Agency for Research on Cancer (IARC). OBJECTIVES: The purpose of this study was to investigate the possible preventive role of vitamin E (Vit E) on aflatoxin (AF) induced toxicity by using biochemical and histopathological approaches. MATERIAL AND METHODS: Wistar-Albino rats were divided into 4 groups as follows: control group, Vit E group (Vit E was administered), AFB1 group (a single dose of AFB1 was administered), AF + Vit E group (AF and Vit E were administered)...
September 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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