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Bel's Palsy

Ju Mizuno, Chikara Namba, Toru Takahashi
We investigated external pressure on peroneal nerve tract coming in contact with two kinds of leg holders using pressure distribution measurement system BIG- MAT® (Nitta Corp., Osaka) in the lithotomy position Peak contact (active) pressure at the left fibular head region coming in contact with knee-crutch-type leg holder M® (Takara Belmont Corp., Osaka), which supports the left popliteal fossa, was 78.0 ± 26.4 mmHg. On the other hand, peak contact pressure at the left lateral lower leg region coming in contact with boot-support-type leg holder Bel Flex® (Takara Belmont Corp...
October 2014: Masui. the Japanese Journal of Anesthesiology
Jill B De Vis, Jeroen Hendrikse, Esben T Petersen, Linda S de Vries, Frank van Bel, Thomas Alderliesten, Simona Negro, Floris Groenendaal, Manon J N L Benders
PURPOSE: Hyperperfusion may be related to outcome in neonates with hypoxic-ischemic encephalopathy (HIE). The purpose of this study was to evaluate whether arterial spin labelling (ASL) perfusion is associated with outcome in neonates with HIE and to compare the predictive value of ASL MRI to known MRI predictive markers. METHODS: Twenty-eight neonates diagnosed with HIE and assessed with MR imaging (conventional MRI, diffusion-weighted MRI, MR spectroscopy [MRS], and ASL MRI) were included...
January 2015: European Radiology
Robert Galinsky, Laura Bennet, Floris Groenendaal, Christopher A Lear, Sidhartha Tan, Frank van Bel, Sandra E Juul, Nicola J Robertson, Carina Mallard, Alistair J Gunn
There is an important unmet need to further improve the outcome of neonatal encephalopathy in term infants. Meta-analyses of large controlled trials now suggest that maternal magnesium sulfate (MgSO4) therapy is associated with a reduced risk of cerebral palsy and gross motor dysfunction after premature birth, but that it has no effect on death or disability. Because of this inconsistency, it remains controversial whether MgSO4 is clinically neuroprotective and, thus, it is unclear whether it would be appropriate to test MgSO4 for treatment of encephalopathy in term infants...
2014: Developmental Neuroscience
Manon J Benders, Niek E van der Aa, Maurice Roks, Henrica L van Straaten, Ivana Isgum, Max A Viergever, Floris Groenendaal, Linda S de Vries, Frank van Bel
OBJECTIVE: To perform a feasibility and safety study with recombinant human erythropoietin (rhEPO) in neonates with perinatal arterial ischemic stroke. STUDY DESIGN: Neonates with a magnetic resonance imaging-confirmed perinatal arterial ischemic stroke (n = 21) were treated with 1000 IU/kg rhEPO immediately after diagnosis and at 24 and 48 hours after the first dose. Repeat magnetic resonance imaging was performed when the patients were 3 months of age. Coagulation and hematologic variables (red blood cells, white blood cells, platelet counts) were performed in the first week after initiation of treatment...
March 2014: Journal of Pediatrics
Laura Bennet, Sidhartha Tan, Lotte Van den Heuij, Matthew Derrick, Floris Groenendaal, Frank van Bel, Sandra Juul, Stephen A Back, Frances Northington, Nicola J Robertson, Carina Mallard, Alistair Jan Gunn
Perinatal hypoxic-ischemic brain injury remains a major cause of cerebral palsy. Although therapeutic hypothermia is now established to improve recovery from hypoxia-ischemia (HI) at term, many infants continue to survive with disability, and hypothermia has not yet been tested in preterm infants. There is increasing evidence from in vitro and in vivo preclinical studies that stem/progenitor cells may have multiple beneficial effects on outcome after hypoxic-ischemic injury. Stem/progenitor cells have shown great promise in animal studies in decreasing neurological impairment; however, the mechanisms of action of stem cells, and the optimal type, dose, and method of administration remain surprisingly unclear, and some studies have found no benefit...
May 2012: Annals of Neurology
Sandra E A de Jong, Floris Groenendaal, Frank van Bel, Karin J Rademaker
Background/Objective. Hydrocortisone, administered to ventilated preterm neonates to facilitate extubation, has no adverse long-term effects, but short-term pulmonary effects have not been described previously. In the present study, we analyzed effects of hydrocortisone on ventilator settings and FiO(2) in ventilator-dependent preterm infants. Patients and Methods. Fifty-five preterm children were included in this retrospective cohort study. Hydrocortisone was administered at a postnatal age of > 7 days to treat chronic lung disease (CLD)...
2011: International Journal of Pediatrics
Joepe J Kaandorp, Manon J N L Benders, Carin M A Rademaker, Helen L Torrance, Martijn A Oudijk, Timo R de Haan, Kitty W M Bloemenkamp, Monique Rijken, Maria G van Pampus, Arie F Bos, Martina M Porath, Sidarto Bambang Oetomo, Christine Willekes, A W Danilo Gavilanes, Maurice G A J Wouters, Ruurd M van Elburg, Anjoke J M Huisjes, Saskia C M J E R Bakker, Claudia A van Meir, Jeannette von Lindern, Janine Boon, Inge P de Boer, Robbert Jp Rijnders, Corrie J W F M Jacobs, Cuno S P M Uiterwaal, Ben Willem J Mol, Gerard H A Visser, Frank van Bel, Jan B Derks
BACKGROUND: Hypoxic-ischaemic encephalopathy is associated with development of cerebral palsy and cognitive disability later in life and is therefore one of the fundamental problems in perinatal medicine. The xanthine-oxidase inhibitor allopurinol reduces the formation of free radicals, thereby limiting the amount of hypoxia-reperfusion damage. In case of suspected intra-uterine hypoxia, both animal and human studies suggest that maternal administration of allopurinol immediately prior to delivery reduces hypoxic-ischaemic encephalopathy...
2010: BMC Pregnancy and Childbirth
Karin J Rademaker, Cuno S P M Uiterwaal, Floris Groenendaal, Monica M A T Uniken Venema, Frank van Bel, Frederik J Beek, Ingrid C van Haastert, Diederick E Grobbee, Linda S de Vries
OBJECTIVE: To investigate neurodevelopment at school age in preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) in the neonatal period. STUDY DESIGN: Preterm infants (n = 226; gestational age < or = 32 weeks and/or body weight < or = 1500 grams) performed subtests of the Wechsler Intelligence Scale for Children-Revised, the Visual Motor Integration test, a 15-Word Memory Test and the Movement Assessment Battery for Children at school age...
April 2007: Journal of Pediatrics
Rosa Rademakers, Stacey Melquist, Marc Cruts, Jessie Theuns, Jurgen Del-Favero, Parvoneh Poorkaj, Matt Baker, Kristel Sleegers, Richard Crook, Tim De Pooter, Samira Bel Kacem, Jennifer Adamson, Dirk Van den Bossche, Marleen Van den Broeck, Jennifer Gass, Ellen Corsmit, Peter De Rijk, Natalie Thomas, Sebastiaan Engelborghs, Michael Heckman, Irene Litvan, Julia Crook, Peter P De Deyn, Dennis Dickson, Gerard D Schellenberg, Christine Van Broeckhoven, Michael L Hutton
Two extended haplotypes exist across the tau gene-H1 and H2-with H1 consistently associated with increased risk of progressive supranuclear palsy (PSP). Using 15 haplotype tagging SNPs (htSNPs), capturing >95% of MAPT haplotype diversity, we performed association analysis in a US sample of 274 predominantly pathologically confirmed PSP patients and 424 matched control individuals. We found that PSP risk is associated with one of two major ancestral H1 haplotypes, H1B, increasing from 14% in control individuals to 22% in PSP patients (P<0...
November 1, 2005: Human Molecular Genetics
F van Bel
Neonatal glucocorticosteroid therapy is increasingly being used for the prevention of chronic lung disease in very premature infants. In the short term this therapy is usually successful. There is, however, increasing evidence for long-term adverse effects. In particular there seems to be an increased chance of abnormal brain development, which later results in locomotory dysfunction, developmental delay and cerebral palsy. From experimental studies there are indications that cardiovascular and immunological complications may occur during adult life...
December 29, 2001: Nederlands Tijdschrift Voor Geneeskunde
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