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https://www.readbyqxmd.com/read/29145165/long-non-coding-rna-dlx6-as1-aggravates-hepatocellular-carcinoma-carcinogenesis-by-modulating-mir-203a-mmp-2-pathway
#1
Lei Zhang, Xiaowei He, Ting Jin, Li Gang, Zhenlin Jin
Long non-coding RNAs (lncRNAs) have been wildly verified to modulate multiple tumorigenesis, especially hepatocellular carcinoma (HCC). In present study, our team aims to investigate the role of lncRNA DLX6-AS1 in the HCC carcinogenesis. Results of early-stage experiments found that DLX6-AS1 expression level was up-regulated in 60 cases of HCC tissue samples compared with adjacent normal tissue. Moreover, the aberrant overexpression of DLX6-AS1 indicated the poor prognosis of HCC patients. Loss-of-function experiments revealed that DLX6-AS1 knockdown inhibited the proliferation, migration and invasion of HCC cells in vitro, and decreased the tumor growth in vivo...
October 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29138205/long-term-prognosis-of-young-breast-cancer-patients-%C3%A2-40-years-who-did-not-receive-adjuvant-systemic-treatment-protocol-for-the-paradigm-initiative-cohort-study
#2
Gwen Mhe Dackus, Natalie D Ter Hoeve, Mark Opdam, Willem Vreuls, Zsuzsanna Varga, Esther Koop, Stefan M Willems, Carolien Hm Van Deurzen, Emilie J Groen, Alicia Cordoba, Jos Bart, Antien L Mooyaart, Jan G van den Tweel, Vicky Zolota, Jelle Wesseling, Anna Sapino, Ewa Chmielik, Ales Ryska, Frederic Amant, Annegien Broeks, Ron Kerkhoven, Nikolas Stathonikos, Mitko Veta, Adri Voogd, Katarzyna Jozwiak, Michael Hauptmann, Marlous Hoogstraat, Marjanka K Schmidt, Gabe Sonke, Elsken van der Wall, Sabine Siesling, Paul J van Diest, Sabine C Linn
INTRODUCTION: Currently used tools for breast cancer prognostication and prediction may not adequately reflect a young patient's prognosis or likely treatment benefit because they were not adequately validated in young patients. Since breast cancers diagnosed at a young age are considered prognostically unfavourable, many treatment guidelines recommend adjuvant systemic treatment for all young patients. Patients cured by locoregional treatment alone are, therefore, overtreated. Lack of prognosticators for young breast cancer patients represents an unmet medical need and has led to the initiation of the PAtients with bReAst cancer DIaGnosed preMenopausally (PARADIGM) initiative...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29136039/exposure-time-running-and-skill-related-performance-in-international-u20-rugby-union-players-during-an-intensified-tournament
#3
Christopher J Carling, Mathieu Lacome, Eamon Flanagan, Pearse O'Doherty, Julien Piscione
PURPOSE: This study investigated exposure time, running and skill-related performance in two international u20 rugby union teams during an intensified tournament: the 2015 Junior World Rugby Championship. METHOD: Both teams played 5 matches in 19 days. Analyses were conducted using global positioning system (GPS) tracking (Viper 2™, Statsports Technologies Ltd) and event coding (Opta Pro®). RESULTS: Of the 62 players monitored, 36 (57.1%) participated in 4 matches and 23 (36...
2017: PloS One
https://www.readbyqxmd.com/read/29123350/evaluation-of-community-based-palliative-care-services-perspectives-from-various-stakeholders
#4
Venugopal Vinayagamoorthy, Elayaperumal Suguna, Amol R Dongre
Background: As a part of Memorandum of Understanding with Tamil Nadu Institute of Palliative Medicine, community-based palliative care services have been initiated 2 years back in our urban field practice areas. Aim: The aim of this study was to evaluate the home care service, a major component of our community-based palliative care, with a view to identify the unmet needs of the services rendered for decision-making about the program. Materials and Methods: It was a descriptive qualitative design carried out by the authors trained in qualitative research methods...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29120252/interprofessional-ethics-education-seminar-for-undergraduate-health-science-students-a-pilot-study
#5
Kathleen Cino, Rita Austin, Cristina Casa, Christine Nebocat, Adele Spencer
To prepare for the modern collaborative healthcare system, health science academia is charged with educating future professionals to be competent members of the interprofessional team. The purpose of this pilot study was to assess self-efficacy for interprofessional education (IPE) in medical laboratory technology, dental hygiene, and nursing students before and after an IPE session. The specific topic of ethics was the focus of the session. The interprofessional seminar was designed to compare the codes of ethics from each programme through discussion and a case-based approach...
November 9, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29119562/validating-performance-of-triss-tarn-and-normit-survival-prediction-models-in-a-norwegian-trauma-population
#6
N O Skaga, T Eken, S Søvik
INTRODUCTION: Anatomic injury, physiological derangement, age, injury mechanism and pre-injury comorbidity are well-founded predictors of trauma outcome. Statistical prediction models may have poorer discrimination, calibration and accuracy when applied in new locations. We aimed to compare the TRISS, TARN and NORMIT survival prediction models in a Norwegian trauma population. METHODS: Consecutive patients admitted to Oslo University Hospital Ullevål within 24 h after injury, with Injury Severity Score ≥ 10, proximal penetrating injuries, or received by trauma team, were studied...
November 8, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29118952/24-hour-survival-after-cardiopulmonary-resuscitation-is-reduced-in-patients-with-diabetes-mellitus
#7
Ali Movahedi, Seyed Reza Mirhafez, Hamidreza Behnam-Voshani, Hamidreza Reihani, Gordon A Ferns, Javad Malekzadeh
Introduction: Diabetes mellitus is a risk factor for cardiovascular disease. Some recent studies have shown an association between diabetes and out-of-hospital cardiac arrest incidence and survival. We aimed to investigate whether there is an association between the presence of diabetes mellitus and survival after cardiopulmonary resuscitation (CPR) in patients with an in-hospital cardiac arrest. Methods: A cross-sectional study was conducted during the period of January to February 2014, among 80 cases of cardiopulmonary arrest in patients at Qaem hospital of Mashhad, Iran...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/29118251/interprofessional-education-in-dental-hygiene-programs-and-coda-standards-dental-hygiene-program-directors-perspectives
#8
Danielle Furgeson, Marita Rohr Inglehart
Purpose: The Patient Protection and Affordable Care Act changed the paradigm of health care delivery by addressing interprofessional education (IPE) and care (IPC). These considerations, combined with evolving dental hygiene (DH) workforce models, challenge DH educators and clinicians alike to embrace IPE and IPC. The objectives of this study were to determine DH program directors' perceptions of the importance of IPE, to assess current and planned activities related to Commission on Dental Accreditation (CODA) standards that imply competency in IPE, and assessment of outcomes...
April 2017: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29116955/patient-injury-assessment-and-treatment-characteristics-and-return-to-play-timelines-after-sport-related-concussion-an-investigation-from-the-athletic-training-practice-based-research-network
#9
Tamara C Valovich McLeod, Nicholas Kostishak, Barton E Anderson, Cailee E Welch Bacon, Kenneth C Lam
OBJECTIVE: To describe the patient, injury, assessment and treatment characteristics, as well as return-to-play timelines and clinical findings at discharge for adolescent patients after sport-related concussion. DESIGN: Retrospective analysis of electronic medical records. SETTING: Athletic training facilities of secondary school members of the Athletic Training Practice-Based Research Network (AT-PBRN). PATIENTS: In total, 1886 patient records were reviewed...
October 25, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29115749/when-study-participants-are-vulnerable-getting-and-keeping-the-right-team
#10
Nikki L Hill, Jacqueline Mogle, Rachel Wion, Ann M Kolanowski, Donna Fick, Liza Behrens, Paula Muhall, Jane McDowell
BACKGROUND: Research assistants (RAs) are critical members of all research teams. When a study involves vulnerable populations, it is particularly important to have the right team members. AIM: To describe the motivations, personal characteristics and team characteristics that promoted the job satisfaction of RAs who worked on two multi-year, randomised clinical trials involving older adults with dementia. DISCUSSION: A survey was conducted with 41 community members who worked as RAs for up to five years...
September 19, 2017: Nurse Researcher
https://www.readbyqxmd.com/read/29110969/how-do-patients-describe-their-disabilities-a-coding-system-for-categorizing-patients-descriptions
#11
Megan A Morris, Jonathan Inselman, Julie M G Rogers, Colin Halverson, Megan Branda, Joan M Griffin
BACKGROUND: To provide care that meets the values and preferences of patients with disabilities, health care providers need to understand patients' perceptions and understanding of their disability. No studies have explored patients' definitions of disability within the healthcare setting. OBJECTIVE: The aim of the study was to understand how patients' define their disability in the healthcare setting and to develop a coding system for categorizing how they describe their disability...
October 23, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29110523/access-to-primary-care-child-weight-management-programs-urban-parent-barriers-and-facilitators-to-participation
#12
Noel L Kulik, Erica M Thomas, Samantha Iovan, Margaret McKeough, Stephanie Kendzierski, Stacy Leatherwood
The prevalence and comorbidities of childhood obesity among low-income urban children are a significant health issue in the United States. Programs designed to assist families are underutilized. The aim of this study is to describe barriers and facilitators relevant to intervention program participation from the perspective of parents who have children who are overweight or obese. Systematic thematic analysis of focus groups and semi-structured interviews with parents from multiple urban pediatrics and family medicine practices were used to gather data...
January 1, 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29109114/pointers-to-earlier-diagnosis-of-endometriosis-a-nested-case-control-study-using-primary-care-electronic-health-records
#13
Christopher Burton, Lisa Iversen, Sohinee Bhattacharya, Dolapo Ayansina, Lucky Saraswat, Derek Sleeman
BACKGROUND: Endometriosis is a condition with relatively non-specific symptoms, and in some cases a long time elapses from first-symptom presentation to diagnosis. AIM: To develop and test new composite pointers to a diagnosis of endometriosis in primary care electronic records. DESIGN AND SETTING: This is a nested case-control study of 366 cases using the Practice Team Information database of anonymised primary care electronic health records from Scotland...
November 6, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29100653/understanding-the-struggles-to-be-a-medical-provider-view-through-medical-student-essays
#14
William J Peterson, Joseph B House, Cemal B Sozener, Sally A Santen
BACKGROUND: The clinical learning environment helps to shape the professional identity of medical students. This process begins from existing personal identity and is influenced by various factors, including clinical experiences and clinical learning environment. OBJECTIVE: The purpose of this study was to examine medical students' reflections as a way to identify and better characterize the modern struggles that medical students face, in order to inform the development of professional identity...
October 31, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29099778/upper-gastrointestinal-bleeding-in-children-a-tertiary-united-kingdom-children-s-hospital-experience
#15
Omar Nasher, David Devadason, Richard J Stewart
The aim of this study was to review the aetiology, presentation and management of these patients with upper gastrointestinal bleeding (UGIB) at a tertiary children's unit in the United Kingdom. This was a retrospective single-institution study on children (<16 years) who presented with acute UGIB over a period of 5 years using known International Classification of Diseases (ICD) codes. A total of 32 children (17 males, 15 females) were identified with a total median age at presentation of 5.5 years. The majority (24/32) of patients presented as an emergency...
November 3, 2017: Children
https://www.readbyqxmd.com/read/29097448/using-simulation-to-develop-care-models-for-rapid-response-and-code-teams-at-a-satellite-facility
#16
Amy R L Rule, Julie Snider, Cheryl Marshall, Kathleen Kramer, Gary L Geis, Ken Tegtmeyer, Craig H Gosdin
BACKGROUND: Our institution recently completed an expansion of an acute care inpatient unit within a satellite hospital that does not include an on-site ICU or PICU. Because of expected increases in volume and acuity, new care models for Rapid Response Teams (RRTs) and Code Blue Teams were necessary. OBJECTIVES: Using simulation-based training, our objectives were to define the optimal roles and responsibilities for team members (including ICU physicians via telemedicine), refine the staffing of RRTs and code Teams, and identify latent safety threats (LSTs) before opening the expanded inpatient unit...
November 2, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29091916/stakeholder-s-experiences-expectations-and-decision-making-on-reproductive-care-an-ethnographic-study-of-three-districts-in-northern-ghana
#17
Martin Amogre Ayanore, Milena Pavlova, Regien Biesma, Wim Groot
BACKGROUND: In Ghana, priority-setting for reproductive health service interventions is known to be rudimentary with little wider stakeholder involvement. In recognizing the need for broad stakeholder engagement to advance reproductive care provision and utilization, it is necessary to jointly study the varied stakeholder views on reproductive care services. METHODS: We applied an ethnographic study approach where field data was collected between March-May 2015 in three rural districts of northern Ghana...
2017: PloS One
https://www.readbyqxmd.com/read/29088920/-some-men-just-don-t-want-to-get-hurt-perspectives-of-u-s-virgin-islands-men-toward-partner-violence-and-hiv-risks
#18
Kamila A Alexander, Noelle M St Vil, Marilyn A Braithwaite-Hall, Michael Sanchez, Aletha Baumann, Gloria B Callwood, Jacquelyn C Campbell, Doris W Campbell
OBJECTIVES: Global evidence suggests that individuals who experience intimate partner violence (IPV) can have accelerated risk for HIV transmission. The U.S. Virgin Islands (USVI) has high per capita rates of HIV and IPV that can have devastating effects on women's health. Catalysts for these health disparities may be shaped by cultural and social definitions of conventional masculinity. Thus, understanding USVI men's perceptions about HIV risks and IPV are a necessary component of developing strategies to improve women's health...
October 31, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29083254/interprofessional-practice-in-different-patient-care-settings-a-qualitative-exploration
#19
Deborah DiazGranados, Alan W Dow, Nital Appelbaum, Paul E Mazmanian, Sheldon M Retchin
Increasing interprofessional practice is seen as a path to improved quality, decreased cost, and enhanced patient experience. However, little is known about how context shapes interprofessional work and how interventions should be crafted to account for a specific setting of interprofessional practice. To better understand, how the work of interprofessional practice differs across patient care settings we sought to understand the social processes found in varying work contexts to better understand how care is provided...
October 30, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29077844/pathways-to-high-and-low-performance-factors-differentiating-primary-care-facilities-under-performance-based-financing-in-nigeria
#20
Shunsuke Mabuchi, Temilade Sesan, Sara C Bennett
The determinants of primary health facility performance in developing countries have not been well studied. One of the most under-researched areas is health facility management. This study investigated health facilities under the pilot performance-based financing (PBF) scheme in Nigeria, and aimed to understand which factors differentiated primary health care centres (PHCCs) which had performed well, vs those which had not, with a focus on health facility management practices. We used a multiple case study where we compared two high-performing PHCCs and two low-performing PHCCs for each of the two PBF target states...
October 25, 2017: Health Policy and Planning
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