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https://www.readbyqxmd.com/read/28610214/revised-morphology-of-i-pycnonemosaurus-i-i-nevesi-i-kellner-amp-campos-2002-theropoda-abelisauridae-and-its-phylogenetic-relationships
#1
Rafael Delcourt
Abelisaurid theropods were most abundant in the Gondwana during the Cretaceous Period. Pycnonemosaurus nevesi Kellner & Campos, 2002 was the first abelisaurid dinosaur described from the Bauru Group (Brazil, Upper Cretaceous). Nevertheless, its initial description was based on the comparison of a restricted number of remains with other abelisaurids. In this paper, I present a new description of the morphology of Pycnonemosaurus nevesi, including three new caudal transverse processes and a discussion of several new characteristics based on perspectives derived from recently described abelisauroids...
June 9, 2017: Zootaxa
https://www.readbyqxmd.com/read/28513695/surface-passivation-and-self-regulated-shell-growth-in-selective-area-grown-gan-al-ga-n-core-shell-nanowires
#2
Martin Hetzl, Julia Winnerl, Luca Francaviglia, Max Kraut, Markus Döblinger, Sonja Matich, Anna Fontcuberta I Morral, Martin Stutzmann
The large surface-to-volume ratio of GaN nanowires implicates sensitivity of the optical and electrical properties of the nanowires to their surroundings. The implementation of an (Al,Ga)N shell with a larger band gap around the GaN nanowire core is a promising geometry to seal the GaN surface. We investigate the luminescence and structural properties of selective area-grown GaN-(Al,Ga)N core-shell nanowires grown on Si and diamond substrates. While the (Al,Ga)N shell allows a suppression of yellow defect luminescence from the GaN core, an overall intensity loss due to Si-related defects at the GaN/(Al,Ga)N interface has been observed in the case of Si substrates...
June 1, 2017: Nanoscale
https://www.readbyqxmd.com/read/28448170/mechanical-circulatory-support-devices-methods-to-optimize-hemodynamics-during-use
#3
Ben Bow Chung, Gabriel Sayer, Nir Uriel
Introduction Mechanical circulatory support (MCS) is an increasingly utilized mode of therapy in the management of advanced heart failure, both as bridge to heart transplantation and destination therapy. As MCS becomes more prevalent, it is ever more important to understand the complex hemodynamics of these devices, as well as the strategies for hemodynamic optimization. Areas Covered This review provides an overview of hemodynamics in the normal human heart and the failing heart. We discuss the various short-term mechanical circulatory support devices and their hemodynamic consequences...
April 27, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28344721/examining-the-impact-of-early-longitudinal-patient-exposure-on-medical-students-career-choices
#4
Jason Kwok, Vincent Wu, Anthony Sanfilippo, Kathryn Bowes, Sheila Pinchin
BACKGROUND: Medical schools include career direction experiences to help students make informed career decisions. Most experiences are short, precluding students from attaining adequate exposure to long-term encounters within medicine. We investigated the impact of the First Patient Program (FPP), which fosters longitudinal patient exposure by pairing junior medical students with chronically ill patients through their healthcare journey, in instilling career direction. METHODS: Medical students who completed at least 6-months in the FPP participated in a cross-sectional survey...
February 2017: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28130634/x-linked-hypophosphatemia-and-growth
#5
REVIEW
R Fuente, H Gil-Peña, D Claramunt-Taberner, O Hernández, A Fernández-Iglesias, L Alonso-Durán, E Rodríguez-Rubio, F Santos
X-Linked hypophosphatemia (XLH) is the most common form of hereditary rickets caused by loss-of function mutations in the PHEX gene. XLH is characterized by hypophosphatemia secondary to renal phosphate wasting, inappropriately low concentrations of 1,25 dihydroxyvitamin D and high circulating levels of fibroblast growth factor 23 (FGF23). Short stature and rachitic osseous lesions are characteristic phenotypic findings of XLH although the severity of these manifestations is highly variable among patients. The degree of growth impairment is not dependent on the magnitude of hypophosphatemia or the extent of legs´ bowing and height is not normalized by chronic administration of phosphate supplements and 1α hydroxyvitamin D derivatives...
March 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28114059/improving-large-scale-image-retrieval-through-robust-aggregation-of-local-descriptors
#6
Syed Sameed Husain, Miroslaw Bober
Visual search and image retrieval underpin numerous applications, however the task is still challenging predominantly due to the variability of object appearance and ever increasing size of the databases, often exceeding billions of images. Prior art methods rely on aggregation of local scale-invariant descriptors, such as SIFT, via mechanisms including Bag of Visual Words (BoW), Vector of Locally Aggregated Descriptors (VLAD) and Fisher Vectors (FV). However, their performance is still short of what is required...
September 27, 2016: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28024779/early-orthodontic-treatment-for-class-iii-malocclusion-a-systematic-review-and-meta-analysis
#7
REVIEW
See Choong Woon, Badri Thiruvenkatachari
INTRODUCTION: Class III malocclusion affects between 5% and 15% of our population. The 2 most common dilemmas surrounding Class III treatment are the timing of treatment and the type of appliance. A number of appliances have been used to correct a Class III skeletal discrepancy, but there is little evidence available on their effectiveness in the long term. Similarly, early treatment of Class III malocclusion has been practiced with increasing interest. However, there has been no solid evidence on the benefits in the long term...
January 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27973546/effect-of-regulatory-element-dna-methylation-on-tissue-type-plasminogen-activator-gene-expression
#8
Sylvie Dunoyer-Geindre, Anne-Sophie Rivier-Cordey, Carlos Caetano, Richard J Fish, Egbert K O Kruithof
Expression of the tissue-type plasminogen activator gene (t-PA; gene name PLAT) is regulated, in part, by epigenetic mechanisms. We investigated the relationship between PLAT methylation and PLAT expression in five primary human cell types and six transformed cell lines. CpG methylation was analyzed in the proximal PLAT gene promoter and near the multihormone responsive enhancer (MHRE) -7.3 kilobase pairs upstream of the PLAT transcriptional start site (TSS, -7.3 kb). In Bowes melanoma cells, the PLAT promoter and the MHRE were fully unmethylated and t-PA secretion was extremely high...
2016: PloS One
https://www.readbyqxmd.com/read/27909144/bone-area-provides-a-responsive-outcome-measure-for-bone-changes-in-short-term-knee-osteoarthritis-studies
#9
Michael A Bowes, Rose A Maciewicz, John C Waterton, David J Hunter, Philip G Conaghan
OBJECTIVE: To analyze the 3-D bone area from an osteoarthritis (OA) cohort demonstrating no change in cartilage thickness. METHODS: Twenty-seven women with painful medial knee OA had magnetic resonance images at 0, 3, and 6 months. Images were analyzed using active appearance models. RESULTS: At 3 and 6 months, the mean change in medial femoral bone area was 0.34% (95% CI 0.04-0.64) and 0.61% (95% CI 0.32-0.90), respectively. Forty-one percent of the subjects had progression greater than the smallest detectable difference at 6 months...
December 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27833291/a-case-report-of-acampomelic-campomelic-dysplasia-and-operative-difficulties-in-cleft-palate-reconstruction
#10
M Pasupathy, Vasant Radhakrishnan, Hirji Sorab Adenwalla, Puthucode V Narayanan
Acampomelic campomelic dysplasia (CD) is a type of CD (CD; OMIM #114290), a rare form of congenital short-limbed dwarfism and is due to mutations in SOX9 gene family. Characteristic phenotypes of CD include bowing of the lower limbs, a narrow thoracic cage, 11 pairs of ribs, hypoplastic scapulae, macrocephaly, flattened supraorbital ridges and nasal bridge, cleft palate and micrognathia. The bending of the long bones is not an obligatory feature and is absent in about 10% of cases, referred to as acampomelic CD...
May 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/27809640/loss-of-functional-osteoprotegerin-more-than-a-skeletal-problem
#11
Corinna Grasemann, Nicole Unger, Matthias Hövel, Diana Arweiler-Harbeck, Ralf Herrmann, Michael M Schündeln, Oliver Müller, Bernd Schweiger, Ekkehart Lausch, Thomas Meissner, Cordula Kiewert, Berthold P Hauffa, Nick J Shaw
Introduction: Juvenile Paget's disease (JPD), an ultra-rare, debilitating bone disease due to loss of functional osteoprotegerin (OPG), is caused by recessive mutations in TNFRFSF11B. A genotype-phenotype correlation spanning from mild to very severe forms is described. Aim: This study aimed to describe the complexity of the human phenotype of OPG deficiency in more detail and to investigate heterozygous mutation carriers for clinical signs of JPD. Patients: We investigated 3 children with JPD from families of Turkish, German, and Pakistani descent and 19 family members (14 heterozygous)...
January 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27803753/diagnostic-implications-of-computed-tomography-pulmonary-angiography-in-patients-with-pulmonary-embolism
#12
Ayman El-Menyar, Syed Nabir, Nadeem Ahmed, Mohammad Asim, Gaby Jabbour, Hassan Al-Thani
INTRODUCTION: Pulmonary embolism (PE) is a serious cardiovascular and pulmonary complication worldwide. We aimed to assess the implications of different computed tomography pulmonary angiography (CTPA) parameters in patients with acute PE. METHODS: A retrospective observational study to include patients presented with clinical suspicious of PE who underwent CTPA was conducted. Patients' demographics, clinical presentation, risk factors, laboratory investigations, management, and outcome were analyzed...
October 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27787584/dynamic-perception-of-dynamic-affordances-walking-on-a-ship-at-sea
#13
Hannah Walter, Jeffrey B Wagman, Nick Stergiou, Nurtekin Erkmen, Thomas A Stoffregen
Motion of the surface of the sea (waves, and swell) causes oscillatory motion of ships at sea. Generally, ships are longer than they are wide. One consequence of this structural difference is that oscillatory ship motion typically will be greater in roll (i.e., the ship rolling from side to side) than in pitch (i.e., the bow and stern rising and falling). For persons on ships at sea, affordances for walking on the open deck should be differentially influenced by ship motion in roll and pitch. Specifically, the minimum width of a walkable path should be greater when walking along the ship's short, or athwart axis than when walking along its long, or fore-aft axis...
February 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27678342/the-effectiveness-acceptability-and-cost-effectiveness-of-psychosocial-interventions-for-maltreated-children-and-adolescents-an-evidence-synthesis
#14
REVIEW
Geraldine Macdonald, Nuala Livingstone, Jennifer Hanratty, Claire McCartan, Richard Cotmore, Maria Cary, Danya Glaser, Sarah Byford, Nicky J Welton, Tania Bosqui, Lucy Bowes, Suzanne Audrey, Gill Mezey, Helen L Fisher, Wendy Riches, Rachel Churchill
BACKGROUND: Child maltreatment is a substantial social problem that affects large numbers of children and young people in the UK, resulting in a range of significant short- and long-term psychosocial problems. OBJECTIVES: To synthesise evidence of the effectiveness, cost-effectiveness and acceptability of interventions addressing the adverse consequences of child maltreatment. STUDY DESIGN: For effectiveness, we included any controlled study...
September 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27515058/position-97-of-hla-b-a-residue-implicated-in-pathogenesis-of-ankylosing-spondylitis-plays-a-key-role-in-cell-surface-free-heavy-chain-expression
#15
Liye Chen, Hui Shi, Jack Yuan, Paul Bowness
OBJECTIVE: Association of position 97 (P97) residue polymorphisms in human leucocyte antigen (HLA)-B, including HLA-B*27, with ankylosing spondylitis (AS) has recently been reported. We studied the effect of P97 variations on cell surface expression of the AS-associated HLA-B*27 and HLA-B*51, and the AS-protective HLA-B*7. METHODS: Flow cytometry was used to measure surface expression of HLA-B*27 in C1R/HeLa cells expressing HLA-B*27 (N97) and six mutants at P97 (N97T, N97S, N97V, N97R, N97W and N97D)...
March 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27478655/maxillofacial-changes-in-melnick-needles-syndrome
#16
Leilane Larissa Albuquerque do Nascimento, Monica da Consolação Canuto Salgueiro, Mariana Quintela, Victor Perez Teixeira, Ana Carolina Costa Mota, Camila Haddad Leal de Godoy, Sandra Kalil Bussadori
Background. Melnick-Needles Syndrome is rare congenital hereditary skeletal dysplasia caused by mutations in the FLNA gene, which codifies the protein filamin A. This condition leads to serious skeletal abnormalities, including the stomatognathic region. Case Presentation. This paper describes the case of a 13-year-old girl diagnosed with Melnick-Needles Syndrome presenting with different forms of skeletal dysplasia, such as cranial hyperostosis, short upper limbs, bowed long bones, metaphyseal thickening, genu valgum (knock-knee), shortened distal phalanges, narrow pelvis and shoulders, rib tapering and irregularities, elongation of the vertebrae, kyphoscoliosis, micrognathia, hypoplastic coronoid processes of the mandible, left stylohyoid ligament suggesting ossification, and dental development anomalies...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27466190/ift52-mutations-destabilize-anterograde-complex-assembly-disrupt-ciliogenesis-and-result-in-short-rib-polydactyly-syndrome
#17
Wenjuan Zhang, S Paige Taylor, Lisette Nevarez, Ralph S Lachman, Deborah A Nickerson, Michael Bamshad, Deborah Krakow, Daniel H Cohn
The short-rib polydactyly syndromes (SRPS) encompass a radiographically and genetically heterogeneous group of skeletal ciliopathies that are characterized by a long narrow chest, short extremities, and variable occurrence of polydactyly. Radiographic abnormalities include undermineralization of the calvarium, shortened and bowed appendicular bones, trident shaped acetabula and polydactyly. In a case of SRPS we identified compound heterozygosity for mutations in IFT52, which encodes a component of the anterograde intraflagellar transport complex...
September 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27422725/identifying-multiple-stressor-controls-on-phytoplankton-dynamics-in-the-river-thames-uk-using-high-frequency-water-quality-data
#18
M J Bowes, M Loewenthal, D S Read, M G Hutchins, C Prudhomme, L K Armstrong, S A Harman, H D Wickham, E Gozzard, L Carvalho
River phytoplankton blooms can pose a serious risk to water quality and the structure and function of aquatic ecosystems. Developing a greater understanding of the physical and chemical controls on the timing, magnitude and duration of blooms is essential for the effective management of phytoplankton development. Five years of weekly water quality monitoring data along the River Thames, southern England were combined with hourly chlorophyll concentration (a proxy for phytoplankton biomass), flow, temperature and daily sunlight data from the mid-Thames...
November 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27415328/search-for-microscopic-and-macroscopic-biaxiality-in-the-cybotactic-nematic-phase-of-new-oxadiazole-bent-core-mesogens
#19
Young-Ki Kim, Greta Cukrov, Francesco Vita, Eric Scharrer, Edward T Samulski, Oriano Francescangeli, Oleg D Lavrentovich
The possibility of biaxial orientational order in nematic liquid crystals is a subject of intense current interest. We explore the tendencies toward local and global biaxial ordering in the recently synthesized trimethylated oxadiazole-based bent-core mesogens with a pronounced asymmetric (bow-type) shape of molecules. The combination of x-ray diffraction and optical studies suggests that the biaxial order is expressed differently at the short- and long-range scales. Locally, at the scale of a few molecules, x-ray-diffraction data demonstrate biaxial packing...
June 2016: Physical Review. E
https://www.readbyqxmd.com/read/27311649/ultrasound-diagnosis-and-percutaneous-treatment-of-achilles-tendon-tethering-a-case-series
#20
Lulu He, Jason Genin, Patricia Delzell
The purpose of this article is to report 3 cases of Kager's fat pad scarring and tethering to the deep surface of the Achilles tendon in patients with Achilles tendinosis symptomatology. The 3 patients were diagnosed sonographically by the use of a dynamic maneuver we described and named the "Kager's squeeze" technique. The key finding for diagnosis is the deformation and bowing of the deep fibers of the Achilles tendon during dynamic squeezing of Kager's fat pad. After diagnosis, the patients were treated with ultrasound-guided hydrodissection and scar release to restore normal motion between Kager's fat pad and the Achilles tendon...
September 2016: Skeletal Radiology
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