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https://www.readbyqxmd.com/read/27909144/bone-area-provides-a-responsive-outcome-measure-for-bone-changes-in-short-term-knee-osteoarthritis-studies
#1
Michael A Bowes, Rose A Maciewicz, John C Waterton, David J Hunter, Philip G Conaghan
OBJECTIVE: To analyze the 3-D bone area from an osteoarthritis (OA) cohort demonstrating no change in cartilage thickness. METHODS: Twenty-seven women with painful medial knee OA had magnetic resonance images at 0, 3, and 6 months. Images were analyzed using active appearance models. RESULTS: At 3 and 6 months, the mean change in medial femoral bone area was 0.34% (95% CI 0.04-0.64) and 0.61% (95% CI 0.32-0.90), respectively. Forty-one percent of the subjects had progression greater than the smallest detectable difference at 6 months...
December 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27833291/a-case-report-of-acampomelic-campomelic-dysplasia-and-operative-difficulties-in-cleft-palate-reconstruction
#2
M Pasupathy, Vasant Radhakrishnan, Hirji Sorab Adenwalla, Puthucode V Narayanan
Acampomelic campomelic dysplasia (CD) is a type of CD (CD; OMIM #114290), a rare form of congenital short-limbed dwarfism and is due to mutations in SOX9 gene family. Characteristic phenotypes of CD include bowing of the lower limbs, a narrow thoracic cage, 11 pairs of ribs, hypoplastic scapulae, macrocephaly, flattened supraorbital ridges and nasal bridge, cleft palate and micrognathia. The bending of the long bones is not an obligatory feature and is absent in about 10% of cases, referred to as acampomelic CD...
May 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/27809640/loss-of-functional-osteoprotegerin-more-than-a-skeletal-problem
#3
Corinna Grasemannn, Nicole Unger, Matthias Hövel, Diana Arweiler-Harbeck, Ralf Herrmann, Michael M Schündeln, Oliver Müller, Bernd Schweiger, Ekkehart Lausch, Thomas Meissner, Cordula Kiewert, Berthold P Hauffa, Nick J Shaw
INTRODUCTION: Juvenile Pagets disease (JPD), an ultra-rare, debilitating bone disease stemming from unopposed RANKL action due to loss of functional osteoprotegerin (OPG) is caused by recessive mutations in TNFRSF11B. A genotype-phenotype correlation spanning from mild to very severe forms is described. AIM: To describe the complexity of the human phenotype of OPG deficiency in more detail and to investigate heterozygous mutation carriers for clinical signs of JPD...
November 3, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27803753/diagnostic-implications-of-computed-tomography-pulmonary-angiography-in-patients-with-pulmonary-embolism
#4
Ayman El-Menyar, Syed Nabir, Nadeem Ahmed, Mohammad Asim, Gaby Jabbour, Hassan Al-Thani
INTRODUCTION: Pulmonary embolism (PE) is a serious cardiovascular and pulmonary complication worldwide. We aimed to assess the implications of different computed tomography pulmonary angiography (CTPA) parameters in patients with acute PE. METHODS: A retrospective observational study to include patients presented with clinical suspicious of PE who underwent CTPA was conducted. Patients' demographics, clinical presentation, risk factors, laboratory investigations, management, and outcome were analyzed...
October 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27787584/dynamic-perception-of-dynamic-affordances-walking-on-a-ship-at-sea
#5
Hannah Walter, Jeffrey B Wagman, Nick Stergiou, Nurtekin Erkmen, Thomas A Stoffregen
Motion of the surface of the sea (waves, and swell) causes oscillatory motion of ships at sea. Generally, ships are longer than they are wide. One consequence of this structural difference is that oscillatory ship motion typically will be greater in roll (i.e., the ship rolling from side to side) than in pitch (i.e., the bow and stern rising and falling). For persons on ships at sea, affordances for walking on the open deck should be differentially influenced by ship motion in roll and pitch. Specifically, the minimum width of a walkable path should be greater when walking along the ship's short, or athwart axis than when walking along its long, or fore-aft axis...
October 27, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27678342/the-effectiveness-acceptability-and-cost-effectiveness-of-psychosocial-interventions-for-maltreated-children-and-adolescents-an-evidence-synthesis
#6
REVIEW
Geraldine Macdonald, Nuala Livingstone, Jennifer Hanratty, Claire McCartan, Richard Cotmore, Maria Cary, Danya Glaser, Sarah Byford, Nicky J Welton, Tania Bosqui, Lucy Bowes, Suzanne Audrey, Gill Mezey, Helen L Fisher, Wendy Riches, Rachel Churchill
BACKGROUND: Child maltreatment is a substantial social problem that affects large numbers of children and young people in the UK, resulting in a range of significant short- and long-term psychosocial problems. OBJECTIVES: To synthesise evidence of the effectiveness, cost-effectiveness and acceptability of interventions addressing the adverse consequences of child maltreatment. STUDY DESIGN: For effectiveness, we included any controlled study...
September 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27515058/position-97-of-hla-b-a-residue-implicated-in-pathogenesis-of-ankylosing-spondylitis-plays-a-key-role-in-cell-surface-free-heavy-chain-expression
#7
Liye Chen, Hui Shi, Jack Yuan, Paul Bowness
OBJECTIVE: Association of position 97 (P97) residue polymorphisms in human leucocyte antigen (HLA)-B, including HLA-B*27, with ankylosing spondylitis (AS) has recently been reported. We studied the effect of P97 variations on cell surface expression of the AS-associated HLA-B*27 and HLA-B*51, and the AS-protective HLA-B*7. METHODS: Flow cytometry was used to measure surface expression of HLA-B*27 in C1R/HeLa cells expressing HLA-B*27 (N97) and six mutants at P97 (N97T, N97S, N97V, N97R, N97W and N97D)...
August 11, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27478655/maxillofacial-changes-in-melnick-needles-syndrome
#8
Leilane Larissa Albuquerque do Nascimento, Monica da Consolação Canuto Salgueiro, Mariana Quintela, Victor Perez Teixeira, Ana Carolina Costa Mota, Camila Haddad Leal de Godoy, Sandra Kalil Bussadori
Background. Melnick-Needles Syndrome is rare congenital hereditary skeletal dysplasia caused by mutations in the FLNA gene, which codifies the protein filamin A. This condition leads to serious skeletal abnormalities, including the stomatognathic region. Case Presentation. This paper describes the case of a 13-year-old girl diagnosed with Melnick-Needles Syndrome presenting with different forms of skeletal dysplasia, such as cranial hyperostosis, short upper limbs, bowed long bones, metaphyseal thickening, genu valgum (knock-knee), shortened distal phalanges, narrow pelvis and shoulders, rib tapering and irregularities, elongation of the vertebrae, kyphoscoliosis, micrognathia, hypoplastic coronoid processes of the mandible, left stylohyoid ligament suggesting ossification, and dental development anomalies...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27466190/ift52-mutations-destabilize-anterograde-complex-assembly-disrupt-ciliogenesis-and-result-in-short-rib-polydactyly-syndrome
#9
Wenjuan Zhang, S Paige Taylor, Lisette Nevarez, Ralph S Lachman, Deborah A Nickerson, Michael Bamshad, Deborah Krakow, Daniel H Cohn
The short-rib polydactyly syndromes (SRPS) encompass a radiographically and genetically heterogeneous group of skeletal ciliopathies that are characterized by a long narrow chest, short extremities, and variable occurrence of polydactyly. Radiographic abnormalities include undermineralization of the calvarium, shortened and bowed appendicular bones, trident shaped acetabula and polydactyly. In a case of SRPS we identified compound heterozygosity for mutations in IFT52, which encodes a component of the anterograde intraflagellar transport complex...
July 27, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27422725/identifying-multiple-stressor-controls-on-phytoplankton-dynamics-in-the-river-thames-uk-using-high-frequency-water-quality-data
#10
M J Bowes, M Loewenthal, D S Read, M G Hutchins, C Prudhomme, L K Armstrong, S A Harman, H D Wickham, E Gozzard, L Carvalho
River phytoplankton blooms can pose a serious risk to water quality and the structure and function of aquatic ecosystems. Developing a greater understanding of the physical and chemical controls on the timing, magnitude and duration of blooms is essential for the effective management of phytoplankton development. Five years of weekly water quality monitoring data along the River Thames, southern England were combined with hourly chlorophyll concentration (a proxy for phytoplankton biomass), flow, temperature and daily sunlight data from the mid-Thames...
November 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27415328/search-for-microscopic-and-macroscopic-biaxiality-in-the-cybotactic-nematic-phase-of-new-oxadiazole-bent-core-mesogens
#11
Young-Ki Kim, Greta Cukrov, Francesco Vita, Eric Scharrer, Edward T Samulski, Oriano Francescangeli, Oleg D Lavrentovich
The possibility of biaxial orientational order in nematic liquid crystals is a subject of intense current interest. We explore the tendencies toward local and global biaxial ordering in the recently synthesized trimethylated oxadiazole-based bent-core mesogens with a pronounced asymmetric (bow-type) shape of molecules. The combination of x-ray diffraction and optical studies suggests that the biaxial order is expressed differently at the short- and long-range scales. Locally, at the scale of a few molecules, x-ray-diffraction data demonstrate biaxial packing...
June 2016: Physical Review. E
https://www.readbyqxmd.com/read/27311649/ultrasound-diagnosis-and-percutaneous-treatment-of-achilles-tendon-tethering-a-case-series
#12
Lulu He, Jason Genin, Patricia Delzell
The purpose of this article is to report 3 cases of Kager's fat pad scarring and tethering to the deep surface of the Achilles tendon in patients with Achilles tendinosis symptomatology. The 3 patients were diagnosed sonographically by the use of a dynamic maneuver we described and named the "Kager's squeeze" technique. The key finding for diagnosis is the deformation and bowing of the deep fibers of the Achilles tendon during dynamic squeezing of Kager's fat pad. After diagnosis, the patients were treated with ultrasound-guided hydrodissection and scar release to restore normal motion between Kager's fat pad and the Achilles tendon...
September 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27233067/novel-compound-heterozygous-mutations-in-inositol-polyphosphate-phosphatase-like-1-in-a-family-with-severe-opsismodysplasia
#13
Cori Feist, Paul Holden, Jamie Fitzgerald
This study aimed to identify the genetic basis of a severe skeletal lethal dysplasia. The main clinical features of two affected fetuses included short limbs with flared metaphyses, bowed radii, femora and tibiae, irregular ossification of hands and feet, and marked platyspondyly. Affected and nonaffected family members were subjected to whole-exome sequencing, followed by immunoblot analysis on amniocytes isolated from one of the affected individuals. Unique compound heterozygous variants in the inositol polyphosphate phosphatase-like 1 (INPPL1) gene encoding the SHIP2 protein were identified in both affected individuals...
October 2016: Clinical Dysmorphology
https://www.readbyqxmd.com/read/27230784/successfully-treated-transoral-crossbow-injury-to-the-axial-spine-causing-mild-neurologic-deficit-case-presentation
#14
Viktor Zsolt Kovari
PURPOSE: To detail the management, complications and results of a crossbow arrow injury, where the broadhead went through the mouth, tongue, soft palate, C2 vertebra, spinal canal, dural sack, exiting the neck posteriorly and the arrow shaft lodged in the spine causing mild spinal cord injury. METHODS: Case presentation. RESULTS: A penetrating axial cervical spine crossbow injury was treated successfully in spite of the following interdisciplinary complications: meningitis, cerebrospinal fluid leakage, re-bleeding, and cardiac arrest...
May 26, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27026435/location-of-fractures-and-the-characteristics-of-patients-with-atypical-femoral-fractures-analyses-of-38-japanese-cases
#15
Kojiro Hyodo, Tomofumi Nishino, Hiroshi Kamada, Daisuke Nozawa, Hajime Mishima, Masashi Yamazaki
The purpose of this study was to determine fracture location and the characteristics of patients with atypical femoral fractures (AFFs). We studied 38 AFFs in 34 patients admitted to our institution between November 2007 and July 2013. The diagnostic criteria for the AFFs were based on 2014 American Society of Bone and Mineral Research guidelines. We classified the fracture location as proximal, middle, or distal to trisect the femoral diaphysis from just distal to the lesser trochanter to just proximal to the supracondylar flare...
March 29, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27006594/beetle-and-plant-arrow-poisons-of-the-ju-hoan-and-hai-om-san-peoples-of-namibia-insecta-coleoptera-chrysomelidae-plantae-anacardiaceae-apocynaceae-burseraceae
#16
Caroline S Chaboo, Megan Biesele, Robert K Hitchcock, Andrea Weeks
The use of archery to hunt appears relatively late in human history. It is poorly understood but the application of poisons to arrows to increase lethality must have occurred shortly after developing bow hunting methods; these early multi-stage transitions represent cognitive shifts in human evolution. This paper is a synthesis of widely-scattered literature in anthropology, entomology, and chemistry, dealing with San ("Bushmen") arrow poisons. The term San (or Khoisan) covers many indigenous groups using so-called 'click languages' in southern Africa...
2016: ZooKeys
https://www.readbyqxmd.com/read/26684106/neutron-star-black-hole-binaries-produced-by-binary-driven-hypernovae
#17
Chris L Fryer, F G Oliveira, J A Rueda, R Ruffini
Binary-driven hypernovae (BdHNe) within the induced gravitational collapse paradigm have been introduced to explain energetic (E_{iso}≳10^{52}  erg), long gamma-ray bursts (GRBs) associated with type Ic supernovae (SNe). The progenitor is a tight binary composed of a carbon-oxygen (CO) core and a neutron-star (NS) companion, a subclass of the newly proposed "ultrastripped" binaries. The CO-NS short-period orbit causes the NS to accrete appreciable matter from the SN ejecta when the CO core collapses, ultimately causing it to collapse to a black hole (BH) and producing a GRB...
December 4, 2015: Physical Review Letters
https://www.readbyqxmd.com/read/26520720/a-new-technique-to-characterize-ct-scanner-bow-tie-filter-attenuation-and-applications-in-human-cadaver-dosimetry-simulations
#18
Xinhua Li, Jim Q Shi, Da Zhang, Sarabjeet Singh, Atul Padole, Alexi Otrakji, Mannudeep K Kalra, X George Xu, Bob Liu
PURPOSE: To present a noninvasive technique for directly measuring the CT bow-tie filter attenuation with a linear array x-ray detector. METHODS: A scintillator based x-ray detector of 384 pixels, 307 mm active length, and fast data acquisition (model X-Scan 0.8c4-307, Detection Technology, FI-91100 Ii, Finland) was used to simultaneously detect radiation levels across a scan field-of-view. The sampling time was as short as 0.24 ms. To measure the body bow-tie attenuation on a GE Lightspeed Pro 16 CT scanner, the x-ray tube was parked at the 12 o'clock position, and the detector was centered in the scan field at the isocenter height...
November 2015: Medical Physics
https://www.readbyqxmd.com/read/26446305/bent-bone-dysplasia-bbd-fgfr2-type-the-radiologic-manifestations-in-early-gestation
#19
Atsuhiko Handa, Yuka Okajima, Noriko Izumi, Michiko Yamanaka, Yasuyuki Kurihara
Bent bone dysplasia-fibroblast growth factor receptor 2 type (BBD-FGFR2) is a recently identified skeletal dysplasia caused by specific FGFR2 mutations, characterized by craniosynostosis and prenatal bowing of the long bones. Only a few cases have been published. We report an affected fetus terminated at 21 weeks of gestation. The clinical and radiologic manifestations mostly recapitulate previous descriptions; however we suggest additional hallmarks of this disorder in early gestation. These hallmarks include distinctive short, thick clavicles and wavy ribs, as well as vertebral bodies that showed striking anteroposterior shortening...
February 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/26429606/plate-fixation-of-proximal-fifth-metatarsal-fracture
#20
Assaf Kadar, Ran Ankory, Ronen Karpf, Elhanan Luger, Shlomo Elias
BACKGROUND: Intramedullary screw fixation of fractures of the proximal fifth metatarsal bone may not be satisfactory in comminuted fractures or when the lateral metatarsal bowing has to be restored. We report our experience with plate fixation in these circumstances. METHODS: Between June 1, 2009, and January 31, 2013, 13 patients who had comminuted fracture or nonunion of fracture of the proximal fifth metatarsal bone underwent plate fixation. Study patients were followed up for a mean of 500 days (range, 51-1238 days)...
September 2015: Journal of the American Podiatric Medical Association
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