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Minimal ovarian stimulation

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https://www.readbyqxmd.com/read/28693957/follicle-stimulating-hormone-encapsulation-in-the-cholesterol-modified-chitosan-nanoparticles-via-molecular-dynamics-simulations-and-binding-free-energy-calculations
#1
Mohammad Yahyaei, Faramarz Mehrnejad, Hossein Naderi-Manesh, Ali Hossein Rezayan
Follicle-stimulating hormone (FSH) is widely applied in the modern ovarian stimulation techniques. However, it must be administered daily because of its short half-life. Recently, the cholesterol (CS) modified chitosan (CTS) nanogels have attracted significant interest as promising controlled release protein delivery because of their ability to minimize the aggregation and irreversible denaturation of proteins. Herein, we report a molecular dynamics (MD) simulation investigation on the molecular mechanisms of FSH encapsulation in the CS-CTS nanogels...
July 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28629583/ex%C3%A2-vivo-retrieval-and-cryopreservation-of-oocytes-from-oophorectomized-specimens-for-fertility-preservation-in-a-brca1-mutation-carrier-with-ovarian-cancer
#2
Nigel Pereira, Andrea G Hubschmann, Jovana P Lekovich, Glenn L Schattman, Zev Rosenwaks
OBJECTIVE: To report a case of ex vivo oocyte retrieval from oophorectomized specimens in a BRCA1 mutation carrier undergoing surgical staging for ovarian cancer. DESIGN: Video case report and literature review. SETTING: University-affiliated center. PATIENT(S): A 37-year-old single woman, gravida 0, with a known BRCA1 mutation, presented to her oncologist with a complex right ovarian mass and elevated CA-125 level...
June 16, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28506951/pharmacokinetic-pharmacodynamic-and-clinical-aspects-of-ovulation-induction-agents-a-review-of-the-literature
#3
Serkan Kahyaoğlu, Bülent Yılmaz, Ahmet Zeki Işık
Controlled ovarian hyperstimulation is a key step for successful outcomes of assisted reproductive technique cycle outcomes. Many medications are available, which are commonly useed solely or in combination to achieve multiple follicular development. Pharmacokinetic, pharmacodynamic, and clinical information of ovulation induction drugs deserve to be elucidated for every individual patient before commencing infertility treatment. New concepts and new treatment protocols are introduced as ovulation physiology is understood by infertility specialists...
March 15, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28505290/supraphysiologic-estradiol-is-an-independent-predictor-of-low-birth-weight-in-full-term-singletons-born-after-fresh-embryo-transfer
#4
N Pereira, R T Elias, P J Christos, A C Petrini, K Hancock, J P Lekovich, Z Rosenwaks
STUDY QUESTION: Is supraphysiologic estradiol (E2) an independent predictor of low birth weight (LBW) in singletons born after fresh IVF-embryo transfer (ET) cycles? SUMMARY ANSWER: Our results suggest that E2 > 2500 pg/ml is an independent predictor for LBW in full-term singletons born to normal responder patients undergoing fresh IVF-ET cycles. WHAT IS KNOWN ALREADY: The pathogenesis of LBW in IVF singletons remains unknown. However, recent studies have suggested that the hyperestrogenic milieu generated during ovarian stimulation may create a sub-optimal peri-implantation environment, leading to placental dysfunction, and therefore, LBW...
May 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28461237/-ovarian-hyperstimulation-syndrome-after-stimulation-with-highly-purified-hmgfor-in-vitro-fertilization-observational-study-shoview
#5
P Barrière, D Dewailly, A Duhamel, V Gayet
OBJECTIVE: Data on the incidence and severity of ovarian hyperstimulation syndrome (OHSS) in France are limited. METHODS: Prospective observational multicentric study (23 French centers of IVF) in a cohort of 421 women treated with highly purified hMG (HP-hMG) for the first or second cycle of IVF with or without ICSI. The primary objective was to assess the incidence of moderate to severe OHSS in this cohort. RESULTS: At inclusion, 172 patients (40...
May 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28344194/an-administration-of-tak-683-at-a-minimally-effective-dose-for-luteinizing-hormone-stimulation-under-the-absence-of-the-ovary-induces-luteinizing-hormone-surge-in-ovary-intact-goats
#6
Nahoko Kanai, Natsumi Endo, Satoshi Ohkura, Yoshihiro Wakabayashi, Hisanori Matsui, Hirokazu Matsumoto, Kaori Ishikawa, Akira Tanaka, Tatsuya Watanabe, Hiroaki Okamura, Tomomi Tanaka
The present study aimed to evaluate hormonal responses and their association with the TAK-683 blood concentrations in goats administered TAK-683 at a low dose, which had been previously determined as the minimally effective dose for luteinizing hormone (LH) stimulation in ovariectomized goats. In Experiment 1, 5 µg of TAK-683 treatment had no significant stimulatory effect on LH secretion in ovariectomized Shiba goats (n = 4). In Experiment 2, cycling goats received the treatment of prostaglandin F2α and progesterone-releasing controlled internal drug releasing (CIDR) to induce the follicular phase, then they were treated with 5 µg of TAK-683 (hour 0) intravenously (n = 4, IV) or subcutaneously (n = 3, SC) or with vehicle intravenously (n = 4, control) at 12 h after CIDR removal...
June 21, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28322539/a-review-on-ovarian-hyperstimulation-syndrome-ohss-management-strategies
#7
Ashley M Eskew, Kenan R Omurtag
Ovarian hyperstimulation syndrome (OHSS) is one of the most frequent, serious and potentially lethal iatrogenic complications of controlled ovarian stimulation. Despite extensive research, the exact pathogenesis of this syndrome remains less clear, but there appears to be a relationship of increased vascular permeability mediated by HCG and other downstream mediators. Adequate experience with ovulation induction therapy and identifying patients with known risk factors are essential in preventing OHSS. As this is a completely iatrogenic disease numerous strategies have been investigated to help decrease the risk of OHSS and their effects on pregnancy and live birth rate...
March 21, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28235465/ovarian-reserve-testing-a-user-s-guide
#8
REVIEW
Reshef Tal, David B Seifer
Ovarian reserve is a complex clinical phenomenon influenced by age, genetics, and environmental variables. Although it is challenging to predict the rate of an individual's ovarian reserve decline, clinicians are often asked for advice about fertility potential and/or recommendations regarding the pursuit of fertility treatment options. The purpose of this review is to summarize the state-of-the-art of ovarian reserve testing, providing a guide for the obstetrician/gynecologist generalist and reproductive endocrinologist...
February 21, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28120035/the-role-of-nrf2-and-atf2-in-resistance-to-platinum-based-chemotherapy
#9
Jianli Chen, Charalambos Solomides, Fiona Simpkins, Henry Simpkins
PURPOSE: Nrf2 and its role in controlling levels of the AKR family of aldo-keto reductases which have been implicated in resistance to platinum-based chemotherapy was studied in ovarian, cervical and lung cell lines. METHODS: Nrf2 shRNA knockdowns of cells from different tumor origins were prepared to determine the role of this factor in producing resistance to platinum chemotherapy. RESULTS: Nrf2 knockdowns resulted in marked decreases in AKR1C1, AKR1C2 and to a lesser extent AKR1C3...
February 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27827818/oocyte-embryo-and-blastocyst-cryopreservation-in-art-systematic-review-and-meta-analysis-comparing-slow-freezing-versus-vitrification-to-produce-evidence-for-the-development-of-global-guidance
#10
Laura Rienzi, Clarisa Gracia, Roberta Maggiulli, Andrew R LaBarbera, Daniel J Kaser, Filippo M Ubaldi, Sheryl Vanderpoel, Catherine Racowsky
BACKGROUND: Successful cryopreservation of oocytes and embryos is essential not only to maximize the safety and efficacy of ovarian stimulation cycles in an IVF treatment, but also to enable fertility preservation. Two cryopreservation methods are routinely used: slow-freezing or vitrification. Slow-freezing allows for freezing to occur at a sufficiently slow rate to permit adequate cellular dehydration while minimizing intracellular ice formation. Vitrification allows the solidification of the cell(s) and of the extracellular milieu into a glass-like state without the formation of ice...
March 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/27685935/oocyte-cryopreservation-for-fertility-preservation-in-women-with-cancer
#11
Javier Domingo, Juan A Garcia-Velasco
PURPOSE OF REVIEW: It is necessary to clarify the fertility preservation-related points of concern that often frighten patients or physicians when it comes to deciding about oocyte cryopreservation for fertility preservation, which are often perceived as procedure limitations, are sometimes real and often theoretical and may make the prognosis worse. RECENT FINDINGS: Letrozole added to gonadotrophins for controlled ovarian stimulation is safe when applied to hormone-sensitive cancer patients as it avoids associated high estradiol levels...
December 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/27651724/a-novel-approach-using-a-minimal-number-of-injections-during-the-ivf-icsi-cycle-luteal-half-dose-depot-gnrh-agonist-following-corifollitropin-alfa-versus-the-corifollitropin-alfa-with-a-gnrh-antagonist-cycle
#12
Bülent Haydardedeoğlu, Esra Bulgan Kılıçdağ
OBJECTIVE: Corifollitropin alfa is a good choice for assisted reproductive technology (ART) cycles because fewer injections are needed than with other agents. In this retrospective cohort, we analyzed luteal injected half-dose depot gonadotropin hormone-releasing hormone (GnRH) agonist cycles in women who received corifollitropin alfa and those who underwent a conventional corifollitropin alfa cycle with a GnRH antagonist. MATERIAL AND METHODS: In this retrospective cohort, we analyzed luteal injected half-dose depot GnRH agonist cycles in women who received corifollitropin alfa and those who underwent a conventional corifollitropin alfa cycle with a GnRH antagonist at the Division of Reproductive Endocrinology and IVF Unit, Obstetrics and Gynecology Department, Başkent University School of Medicine, Adana, Turkey, from March 2014 to August 2015...
2016: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/27563236/pivet-rfsh-dosing-algorithms-for-individualized-controlled-ovarian-stimulation-enables-optimized-pregnancy-productivity-rates-and-avoidance-of-ovarian-hyperstimulation-syndrome
#13
John L Yovich, Birgit Alsbjerg, Jason L Conceicao, Peter M Hinchliffe, Kevin N Keane
The first PIVET algorithm for individualized recombinant follicle stimulating hormone (rFSH) dosing in in vitro fertilization, reported in 2012, was based on age and antral follicle count grading with adjustments for anti-Müllerian hormone level, body mass index, day-2 FSH, and smoking history. In 2007, it was enabled by the introduction of a metered rFSH pen allowing small dosage increments of ~8.3 IU per click. In 2011, a second rFSH pen was introduced allowing more precise dosages of 12.5 IU per click, and both pens with their individual algorithms have been applied continuously at our clinic...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27486273/getting-older-women-pregnant-contemporary-thoughts
#14
Gautam N Allahbadia
For women of advanced age with abnormally increased FSH levels, standardized hormonal stimulation often represents a cost-intensive procedure with a low success rate. It is well established now that with mild ovarian stimulation, there is a greater percentage of good-quality eggs (although a smaller number) than with higher-dose conventional stimulation. Mild stimulation protocols reduce the mean number of days of stimulation, the total amount of gonadotropins used and the mean number of oocytes retrieved. The proportion of high-quality and euploid embryos seems to be higher compared with conventional stimulation protocols, and the pregnancy rate per embryo transfer is comparable...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27441046/resurgence-of-minimal-stimulation-in-vitro-fertilization-with-a-protocol-consisting-of-gonadotropin-releasing-hormone-agonist-trigger-and-vitrified-thawed-embryo-transfer
#15
REVIEW
John Zhang
Minimal stimulation in vitro fertilization (mini-IVF) consists of a gentle controlled ovarian stimulation that aims to produce a maximum of five to six oocytes. There is a misbelief that mini-IVF severely compromises pregnancy and live birth rates. An appraisal of the literature pertaining to studies on mini-IVF protocols was performed. The advantages of minimal stimulation protocols are reported here with a focus on the use of clomiphene citrate (CC), gonadotropin releasing hormone (GnRH) ago- nist trigger for oocyte maturation, and freeze-all embryo strategy...
July 2016: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/27385972/comparison-pregnancy-outcomes-between-minimal-stimulation-protocol-and-conventional-gnrh-antagonist-protocols-in-poor-ovarian-responders
#16
Shamim Pilehvari, Ensieh ShahrokhTehraninejad, Batool Hosseinrashidi, Fatemeh Keikhah, Fedyeh Haghollahi, Elham Aziminekoo
OBJECTIVE: To compare the pregnancy outcomes achieved by in vitro fertilization (IVF) between minimal stimulation and conventional antagonist protocols in poor ovarian responders (PORs). MATERIALS AND METHODS: In this randomized controlled trial, 77 PORs undergoing IVF were selected and divided into two groups. First group was the minimal stimulation group (n = 42) receiving 100 mg/day clomiphene citrate on day 2of the cycle for 5 day that was followed by150IU/day human menopausal gonadotropin (hMG) on day 5 of the cycle...
March 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/27337842/-minimal-and-mild-endometriosis-which-impact-on-fertility
#17
REVIEW
G Brichant, A Audebert, M Nisolle
Minimal and mild endometriosis (stages I/II) is frequently identified in subfertile patients, especially in case of unexplained infertility. The impact of those lesions on fecundity is still debatted and they have been considered as paraphysiological by some experts. In addition, they are heterogenous with variable spread, biological activity, induced inflammation and, sometimes, the presence of associated mild adhesions. Stages I/II endometriosis are the most frequent endometriotic lesions encountered in subfertile women...
May 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/27312534/ovarian-injury-during-cryopreservation-and-transplantation-in-mice-a-comparative-study-between-cryoinjury-and-ischemic-injury
#18
Jaewang Lee, Hyun Sun Kong, Eun Jung Kim, Hye Won Youm, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
STUDY QUESTION: What is the main cause of ovarian injury during cryopreservation and transplantation in mice: cryoinjury or ischemic injury? SUMMARY ANSWER: Post-transplantation ischemia is the main cause of ovarian injury during cryopreservation and transplantation for restoring ovarian function. WHAT IS KNOWN ALREADY: During cryopreservation and the transplantation of ovaries, cryoinjury and ischemic injury inevitably occur, which has a detrimental effect on ovarian quality and reserve...
August 2016: Human Reproduction
https://www.readbyqxmd.com/read/27246873/melittin-mil-2-fusion-protein-as-a-candidate-for-cancer-immunotherapy
#19
Mingjun Liu, Haitao Wang, Linjie Liu, Bin Wang, Guirong Sun
BACKGROUND: Cytokine fusion protein that modulates the immune response holds great potential for cancer immunotherapy. IL-2 is an effective treatment against advanced cancers. However, the therapeutic efficacy of IL-2 is limited by severe systemic toxicity. Several mutants recombinant IL-2 can increase antitumor activity and minimize systemic toxicity. Melittin is an attractive anticancer candidate because of its wide-spectrum lytic properties. We previously generated a bifunctional fusion protein melittin-MIL-2, composed of melittin and a mutant IL-2...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27196085/hysterectomy-for-benign-disease-clinical-practice-guidelines-from-the-french-college-of-obstetrics-and-gynecology
#20
Xavier Deffieux, Bertrand de Rochambeau, Gautier Chene, Tristan Gauthier, Samantha Huet, Géry Lamblin, Aubert Agostini, Maxime Marcelli, François Golfier
OBJECTIVE: The objective of the study was to draw up French College of Obstetrics and Gynecology (CNGOF) clinical practice guidelines based on the best available evidence concerning hysterectomy for benign disease. METHODS: Each recommendation for practice was allocated a grade, which depends on the level of evidence (clinical practice guidelines). RESULTS: Hysterectomy should be performed by a high-volume surgeon (>10 hysterectomy procedures per year) (gradeC)...
July 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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