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Minimal ovarian stimulation

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https://www.readbyqxmd.com/read/29387409/fertility-preservation-in-post-pubescent-female-cancer-patients-a-practical-guideline-for-clinicians
#1
Amirrtha Srikanthan, Eitan Amir, Philippe Bedard, Meredith Giuliani, David Hodgson, Stephanie Laframboise, Anca Prica, Karen Yee, Ellen Greenblatt, Jeremy Lewin, Abha Gupta
Increasing accessibility of fertility preservation (FP) options has permitted women to retain fertility following anticancer therapies. Several published guidelines have made recommendations for FP however their implementation into practice is currently unknown. In this review, we aim to provide oncology clinicians practical information about FP options for post-pubescent female cancer patients and recommendations for care delivery in order to answer preliminary questions and help triage whether FP referral is appropriate...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29386467/alkaloids-from-stephania-venosa-as-chemo-sensitizers-in-skov3-ovarian-cancer-cells-via-akt-nf-%C3%AE%C2%BAb-signaling
#2
May Thuu Mon, Supachai Yodkeeree, Wanisa Punfa, Wilart Pompimon, Pornngarm Limtrakul
Crebanine (CN), tetrahydropalmatine (THP), O-methylbulbocapnine (OMBC) and N-methyl tetrahydropalmatine (NMTHP) are isoquinoline derived natural alkaloids isolated from tubers of Stephania venosa. We investigated chemo-sensitizing effects of these alkaloids in ovarian cancer cells and evaluated underlying molecular mechanisms involved in chemo-sensitivity. Detection of cell apoptosis was evaluated by using flow cytometry. Cell viability was analyzed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29365049/reproductive-failure-in-mice-expressing-transgenic-follicle-stimulating-hormone-is-not-caused-by-loss-of-oocyte-quality
#3
Dannielle H Upton, Kirsty A Walters, Kirsten J McTavish, Janet Holt, David J Handelsman, Charles M Allan
Human female reproductive aging features declining ovarian follicle reserve and oocyte quality, and rising levels of circulating follicle stimulating hormone (FSH). We determined the effects of elevated FSH on oocyte-embryo development in mature mice exhibiting premature infertility caused by progressively rising transgenic human FSH (TgFSH) levels. Oocyte-embryo developmental competence and quality were examined using oocyte maturation and aneuploidy rates, biomarkers of oocyte quality, and reciprocal embryo transfers assessed for implantation and pregnancy...
January 22, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29338139/occurrence-of-ovarian-follicular-dominance-during-stimulation-for-ivm-impacts-usable-blastocyst-yield
#4
Sergio Romero, Ricardo Pella, Francisco Escudero, Ygor Pérez, Mario García, Patricia Orihuela
OBJECTIVE: To evaluate the influence of ovarian follicular dominance on the outcome of oocyte in-vitro maturation. METHODS: This retrospective cohort study included 21 patients with polycystic ovaries or polycystic ovary syndrome (Rotterdam criteria, 2004) subjected to 24 in-vitro maturation (IVM) cycles between October 2015 and January 2017. Patients undergoing IVM received minimal gonadotropin stimulation starting on day 2 or 3 of the cycle; ovum pick-up typically occurred on days 6 to 8...
January 17, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29247565/oocyte-oxidative-dna-damage-may-be-involved-in-minimal-mild-endometriosis-related-infertility
#5
Michele Gomes Da Broi, Alceu Afonso Jordão-Jr, Rui Alberto Ferriani, Paula Andrea Navarro
Early endometriosis is associated with infertility, and oxidative stress may play a role in the pathogenesis of disease-related infertility. This prospective case-control study aimed to compare the presence of oxidative stress markers in the follicular microenvironment and systemic circulation of infertile women with minimal/mild endometriosis (EI/II) versus individuals undergoing controlled ovarian stimulation for intracytoplasmic sperm injection (ICSI). Seventy-one blood samples (27 from infertile women with EI/II and 44 controls with tubal and/or male infertility factor) and 51 follicular fluid samples (19 EI/II and 32 controls) were obtained on the day of oocyte retrieval...
December 16, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29198847/first-delivery-in-a-leukemia-survivor-after-transplantation-of-cryopreserved-ovarian-tissue-evaluated-for-leukemia-cells-contamination
#6
Moran Shapira, Hila Raanani, Iris Barshack, Ninette Amariglio, Sanaz Derech-Haim, Meital Nagar Marciano, Eyal Schiff, Raoul Orvieto, Dror Meirow
OBJECTIVE: To describe a successful autologous ovarian tissue re-transplantation in a sterile leukemia survivor after evaluation for minimal residual disease and provide a review of the current literature. DESIGN: Presentation of a carefully designed workup taken to evaluate tissue for minimal residual disease, its limitations, and applicability to other patients. To date, there have not been any publications of auto-transplantations in leukemia survivors, owing to an estimated high risk for malignancy induction...
November 29, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29129407/finding-a-place-for-corifollitropin-within-the-pivet-fsh-dosing-algorithms
#7
John L Yovich, Kevin N Keane, Gayatri Borude, Satvinder S Dhaliwal, Peter M Hinchliffe
PIVET recombinant FSH (rFSH) dosing algorithms have been designed for rFSH injection pens, providing optimal pregnancy and live birth productivity rates whilst minimizing risk and occurrence of ovarian hyperstimulation syndrome (OHSS). Recently, long-acting recombinant gonadotrophin corifollitropin (Elonva) was approved for use in assisted reproduction, and welcomed by patients as the single injection allowed ovarian stimulation over 7 days without need for multiple injections. Consequently, another rFSH dosing algorithm was devised to incorporate Elonva, and these cycles were compared to standard rFSH agents, Gonal-f and Puregon...
October 31, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28925272/-fertility-preserving-methods-in-women-with-breast-cancer-before-gonadotoxic-therapy
#8
N Halászová, I Crha, M Huser, V Weinberger, J Žáková, M Ješeta, E Lousová, E Filipinská, P Ventruba
OBJECTIVE: To present current options and own experiences with ovarian stimulation in young women with breast cancer before gonadotoxic therapy. DESIGN: Review article with own experiencies. METHODS: Literary search, analysis of own experiences with complex therapy in women with breast cancer planning pregnancy, definitions of stimulating protocols, using methods of assisted reproduction. SETTING: Department of Obstetrics and Gynecology, Faculty of Medicine, Masaryk University and University Hospital Brno...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28870891/lidocaine-stimulates-the-function-of-natural-killer-cells-in-different-experimental-settings
#9
REVIEW
Juan P Cata, Maria F Ramirez, Jose F Velasquez, A I Di, Keyuri U Popat, Vijaya Gottumukkala, Dahlia M Black, Valerae O Lewis, Jean N Vauthey
BACKGROUND: One of the functions of natural killer (NK) cells is to eliminate cancer cells. The cytolytic activity of NK cells is tightly regulated by inhibitory and activation receptors located in the surface membrane. Lidocaine stimulates the function of NK cells at clinically relevant concentrations. It remains unknown whether this effect of lidocaine has an impact on the expression of surface receptors of NK cells, can uniformly stimulate across different cancer cell lines, and enhances the function of cells obtained during oncological surgery...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870217/controlled-ovulation-of-the-dominant-follicle-using-progestin-in-minimal-stimulation-in-poor-responders
#10
Qiuju Chen, Yun Wang, Lihua Sun, Shaozhen Zhang, Weiran Chai, Qingqing Hong, Hui Long, Li Wang, Qifeng Lyu, Yanping Kuang
BACKGROUND: The use of progestin (P) during ovarian stimulation is effective in blocking the luteinizing hormone (LH) surge in women with normal ovarian reserve, however, its effects have not been determined in poor responders. This study aimed to explore the follicular dynamics in P-primed minimal stimulation in poor responders. METHODS: A total of 204 infertile women with diminished ovarian reserve were allocated into the medroxyprogesterone acetate (MPA) group or the natural-cycle control group in an alternating order...
September 5, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28854580/ovarian-response-to-controlled-ovarian-hyperstimulation-what-does-serum-fsh-say
#11
Simone C Oudshoorn, Theodora C van Tilborg, Ouijdane Hamdine, Helen L Torrance, Marinus J C Eijkemans, Eef G W M Lentjes, Cornelis B Lambalk, Frank J M Broekmans
STUDY QUESTION: Do serum FSH levels on day of hCG trigger differ between women with a poor, normal or hyper response to a fixed daily dose of 150 IU recombinant FSH (rFSH)? SUMMARY ANSWER: There is no consistent relationship between ovarian response and serum FSH levels on day of hCG trigger in a 150 IU fixed dose treatment protocol. WHAT IS KNOWN ALREADY: When ovarian response to stimulation for IVF/ICSI is suboptimal, the FSH dose is often adjusted in a subsequent cycle, thereby assuming that serum FSH levels were inadequate for optimal stimulation...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28693957/follicle-stimulating-hormone-encapsulation-in-the-cholesterol-modified-chitosan-nanoparticles-via-molecular-dynamics-simulations-and-binding-free-energy-calculations
#12
Mohammad Yahyaei, Faramarz Mehrnejad, Hossein Naderi-Manesh, Ali Hossein Rezayan
Follicle-stimulating hormone (FSH) is widely applied in the modern ovarian stimulation techniques. However, it must be administered daily because of its short half-life. Recently, the cholesterol (CS) modified chitosan (CTS) nanogels have attracted significant interest as promising controlled release protein delivery because of their ability to minimize the aggregation and irreversible denaturation of proteins. Herein, we report a molecular dynamics (MD) simulation investigation on the molecular mechanisms of FSH encapsulation in the CS-CTS nanogels...
July 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28629583/ex%C3%A2-vivo-retrieval-and-cryopreservation-of-oocytes-from-oophorectomized-specimens-for-fertility-preservation-in-a-brca1-mutation-carrier-with-ovarian-cancer
#13
Nigel Pereira, Andrea G Hubschmann, Jovana P Lekovich, Glenn L Schattman, Zev Rosenwaks
OBJECTIVE: To report a case of ex vivo oocyte retrieval from oophorectomized specimens in a BRCA1 mutation carrier undergoing surgical staging for ovarian cancer. DESIGN: Video case report and literature review. SETTING: University-affiliated center. PATIENT(S): A 37-year-old single woman, gravida 0, with a known BRCA1 mutation, presented to her oncologist with a complex right ovarian mass and elevated CA-125 level...
August 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28506951/pharmacokinetic-pharmacodynamic-and-clinical-aspects-of-ovulation-induction-agents-a-review-of-the-literature
#14
Serkan Kahyaoğlu, Bülent Yılmaz, Ahmet Zeki Işık
Controlled ovarian hyperstimulation is a key step for successful outcomes of assisted reproductive technique cycle outcomes. Many medications are available, which are commonly useed solely or in combination to achieve multiple follicular development. Pharmacokinetic, pharmacodynamic, and clinical information of ovulation induction drugs deserve to be elucidated for every individual patient before commencing infertility treatment. New concepts and new treatment protocols are introduced as ovulation physiology is understood by infertility specialists...
March 15, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28505290/supraphysiologic-estradiol-is-an-independent-predictor-of-low-birth-weight-in-full-term-singletons-born-after-fresh-embryo-transfer
#15
N Pereira, R T Elias, P J Christos, A C Petrini, K Hancock, J P Lekovich, Z Rosenwaks
STUDY QUESTION: Is supraphysiologic estradiol (E2) an independent predictor of low birth weight (LBW) in singletons born after fresh IVF-embryo transfer (ET) cycles? SUMMARY ANSWER: Our results suggest that E2 > 2500 pg/ml is an independent predictor for LBW in full-term singletons born to normal responder patients undergoing fresh IVF-ET cycles. WHAT IS KNOWN ALREADY: The pathogenesis of LBW in IVF singletons remains unknown. However, recent studies have suggested that the hyperestrogenic milieu generated during ovarian stimulation may create a sub-optimal peri-implantation environment, leading to placental dysfunction, and therefore, LBW...
July 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28461237/-ovarian-hyperstimulation-syndrome-after-stimulation-with-highly-purified-hmgfor-in-vitro-fertilization-observational-study-shoview
#16
P Barrière, D Dewailly, A Duhamel, V Gayet
OBJECTIVE: Data on the incidence and severity of ovarian hyperstimulation syndrome (OHSS) in France are limited. METHODS: Prospective observational multicentric study (23 French centers of IVF) in a cohort of 421 women treated with highly purified hMG (HP-hMG) for the first or second cycle of IVF with or without ICSI. The primary objective was to assess the incidence of moderate to severe OHSS in this cohort. RESULTS: At inclusion, 172 patients (40...
May 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28344194/an-administration-of-tak-683-at-a-minimally-effective-dose-for-luteinizing-hormone-stimulation-under-the-absence-of-the-ovary-induces-luteinizing-hormone-surge-in-ovary-intact-goats
#17
Nahoko Kanai, Natsumi Endo, Satoshi Ohkura, Yoshihiro Wakabayashi, Hisanori Matsui, Hirokazu Matsumoto, Kaori Ishikawa, Akira Tanaka, Tatsuya Watanabe, Hiroaki Okamura, Tomomi Tanaka
The present study aimed to evaluate hormonal responses and their association with the TAK-683 blood concentrations in goats administered TAK-683 at a low dose, which had been previously determined as the minimally effective dose for luteinizing hormone (LH) stimulation in ovariectomized goats. In Experiment 1, 5 µg of TAK-683 treatment had no significant stimulatory effect on LH secretion in ovariectomized Shiba goats (n = 4). In Experiment 2, cycling goats received the treatment of prostaglandin F2α and progesterone-releasing controlled internal drug releasing (CIDR) to induce the follicular phase, then they were treated with 5 µg of TAK-683 (hour 0) intravenously (n = 4, IV) or subcutaneously (n = 3, SC) or with vehicle intravenously (n = 4, control) at 12 h after CIDR removal...
June 21, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28322539/a-review-on-ovarian-hyperstimulation-syndrome-ohss-management-strategies
#18
Ashley M Eskew, Kenan R Omurtag
Ovarian hyperstimulation syndrome (OHSS) is one of the most frequent, serious and potentially lethal iatrogenic complications of controlled ovarian stimulation. Despite extensive research, the exact pathogenesis of this syndrome remains less clear, but there appears to be a relationship of increased vascular permeability mediated by HCG and other downstream mediators. Adequate experience with ovulation induction therapy and identifying patients with known risk factors are essential in preventing OHSS. As this is a completely iatrogenic disease numerous strategies have been investigated to help decrease the risk of OHSS and their effects on pregnancy and live birth rate...
March 21, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28235465/ovarian-reserve-testing-a-user-s-guide
#19
REVIEW
Reshef Tal, David B Seifer
Ovarian reserve is a complex clinical phenomenon influenced by age, genetics, and environmental variables. Although it is challenging to predict the rate of an individual's ovarian reserve decline, clinicians are often asked for advice about fertility potential and/or recommendations regarding the pursuit of fertility treatment options. The purpose of this review is to summarize the state-of-the-art of ovarian reserve testing, providing a guide for the obstetrician/gynecologist generalist and reproductive endocrinologist...
August 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28120035/the-role-of-nrf2-and-atf2-in-resistance-to-platinum-based-chemotherapy
#20
Jianli Chen, Charalambos Solomides, Fiona Simpkins, Henry Simpkins
PURPOSE: Nrf2 and its role in controlling levels of the AKR family of aldo-keto reductases which have been implicated in resistance to platinum-based chemotherapy was studied in ovarian, cervical and lung cell lines. METHODS: Nrf2 shRNA knockdowns of cells from different tumor origins were prepared to determine the role of this factor in producing resistance to platinum chemotherapy. RESULTS: Nrf2 knockdowns resulted in marked decreases in AKR1C1, AKR1C2 and to a lesser extent AKR1C3...
February 2017: Cancer Chemotherapy and Pharmacology
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