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Therapeutic ultrasound

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https://www.readbyqxmd.com/read/29933275/incidence-of-venous-air-embolism-during-endoscopic-retrograde-cholangiopancreatography
#1
Lubana K Afreen, Ayesha S Bryant, Tetsuzo Nakayama, Timothy J Ness, Keith A Jones, Charity J Morgan, Charles M Wilcox, Mark C Phillips
BACKGROUND: Known complications of endoscopic retrograde cholangiopancreatography (ERCP) include pancreatitis, bleeding, duodenal perforation, and venous air embolism (VAE). The aim of this study was to determine the incidence of VAE during ERCP and be able to differentiate high-risk versus low-risk ERCP procedures. METHODS: This is a prospective cohort study consisting of patients who underwent ERCP and were monitored with a precordial Doppler ultrasound (PDU) for VAE...
June 20, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29927437/-morphological-changes-in-tumor-and-nontumor-tissue-in-the-treatment-of-prostate-adenocarcinoma-with-high-intensity-focused-ultrasound-in-combination-with-androgen-deprivation
#2
M A Bakarev, V P Levin, I V Kachesov, A I Neimark
OBJECTIVE: To investigate structural changes in the tumor and nontumor tissues of the prostate in patients with its cancer (PC) after treatment with high-intensity focused ultrasound (HIFU) in combination with androgen deprivation to clarify criteria for evaluating the efficiency of treatment. SUBJECT AND METHODS: Comparative morphological, immunohistochemical, and morphometric analyses were carried out to examine 253 pre- and postoperative biopsy specimens, as well as transurethral resection specimens from 32 patients with localized PC and with or without a local recurrence within 3 years after a HIFU session...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29925125/-technical-specification-for-clinical-application-of-critical-ultrasonography
#3
M G Yin, X T Wang, D W Liu, Y G Chao, X D Guan, Y Kang, J Yan, X C Ma, Y Q Tang, Z J Hu, K J Yu, D C Chen, Y H Ai, L N Zhang, H M Zhang, J Wu, L X Liu, R Zhu, W He, Q Zhang, X Ding, L Li, Y Li, H T Liu, Q B Zeng, X Si, H Chen, J W Zhang, Q H Xu, W J Chen, X K Chen, D Z Huang, S H Cai, X L Shang, J Guan, J Du, L Zhao, M J Wang, S Cui, X M Wang, R Zhou, X Y Zeng, Y P Wang, L W Lyu, W H Zhu, Y Zhu, J Duan, J Yang, H Yang
Critical ultrasonography(CUS) is different from the traditional diagnostic ultrasound, the examiner and interpreter of the image are critical care medicine physicians. The core content of CUS is to evaluate the pathophysiological changes of organs and systems and etiology changes. With the idea of critical care medicine as the soul, it can integrate the above information and clinical information, bedside real-time diagnosis and titration treatment, and evaluate the therapeutic effect so as to improve the outcome...
June 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29924202/glaucoma-due-to-ciliary-body-cysts-and-pseudoplateau-iris-a-systematic-review-of-the-literature
#4
Tiago Ribeiro Schmalfuss, Egidio Picetti, Helena Messinger Pakter
The diagnosis of angle-closure glaucoma secondary to iridociliary cysts is challenging and lacks compiled literature support. We present a rare case of bilateral angle-closure glaucoma associated with pseudoplateau iris due to multiple ciliary cysts and conducted a systematic review of the literature to find similar case reports published between November 2006 and November 2016. Only 19 case reports present treatment modalities, and most cases required more than one therapeutic approach for controlling the intraocular pressure...
June 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29922765/therapeutic-intranodal-lymphangiography-for-refractory-chylous-ascites-complicating-acute-necrotic-pancreatitis
#5
Thomas Jardinet, Len Verbeke, Lawrence Bonne, Geert Maleux
Chylous ascites is a rare complication of acute pancreatitis. However, the incidence of intraperitoneal chyle leakage related to severe pancreatitis may be much higher. This is probably the result of direct damage to the cisterna chyli or its tributaries by pancreatic enzymes. In this case, conservative treatment failed to resolve the chyle leak. For the first time, to our knowledge, ultrasound guided therapeutic intranodal lymphangiography was shown to be a successful, minimally invasive treatment option in chylous ascites complicating acute necrotic pancreatitis...
June 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/29922635/late-seed-migration-after-prostate-brachytherapy-with-iod-125-permanent-implants
#6
Philipp Maletzki, Christoph Schwab, Patrick Markart, Daniel Engeler, Johann Schiefer, Ludwig Plasswilm, Hans-Peter Schmid
Background: Seed migration is a common finding after low dose rate brachytherapy of the prostate. It has often been assessed soon after implantation, but little is known about late seed migration. We evaluated the incidence, site, symptoms, and therapeutic consequences of late seed migration more than 3 years postoperatively. Materials and methods: We retrospectively examined the data of 63 unselected patients with transrectal ultrasound-guided, transperineal low dose rate brachytherapy of the prostate with stranded seeds between 2001 and 2010...
June 2018: Prostate International
https://www.readbyqxmd.com/read/29921611/smggds-prevents-thoracic-aortic-aneurysm-formation-and-rupture-by-phenotypic-preservation-of-aortic-smooth-muscle-cells
#7
Masamichi Nogi, Kimio Satoh, Shinichiro Sunamura, Nobuhiro Kikuchi, Taijyu Satoh, Ryo Kurosawa, Junichi Omura, Md Elias Al-Mamun, Mohammad Abdul Hai Siddique, Kazuhiko Numano, Shun Kudo, Satoshi Miyata, Masatoshi Akiyama, Kiichiro Kumagai, Shunsuke Kawamoto, Yoshikatsu Saiki, Hiroaki Shimokawa
Background -Thoracic aortic aneurysm (TAA) and dissection (TAD) are fatal diseases, which cause aortic rupture and sudden death. The small GTP-binding protein GDP dissociation stimulator (SmgGDS) is a crucial mediator of the pleiotropic effects of statins. Previous studies revealed that reduced force generation in AoSMCs causes TAA and TAD. Methods -To examine the role of SmgGDS in TAA formation, we employed an angiotensin II (AngII, 1,000 ng/min/kg, 4 weeks)-induced TAA model. Results -33% Apoe-/- SmgGDS+/- mice died suddenly due to TAA rupture, whereas there was no TAA rupture in Apoe-/- control mice...
June 19, 2018: Circulation
https://www.readbyqxmd.com/read/29921317/bone-marrow-mesenchymal-stem-cells-do-not-enhance-intra-synovial-tendon-healing-despite-engraftment-and-homing-to-niches-within-the-synovium
#8
Mohammad R Khan, Jayesh Dudhia, Frederic H David, Roberta De Godoy, Vedika Mehra, Gillian Hughes, Stephanie G Dakin, Andrew J Carr, Allen E Goodship, Roger K W Smith
BACKGROUND: Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon repair with autologous mesenchymal stem cells (MSCs) although the effects of the intra-synovial environment on the distribution, engraftment and functionality of implanted MSCs is not known. This study utilised a novel sheep model which, although in an anatomically different location, more accurately mimics the mechanical and synovial environment of the human rotator cuff, to determine the effects of intra-synovial implantation of MSCs...
June 19, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29910847/dissolved-oxygen-scavenging-by-acoustic-droplet-vaporization-using-intravascular-ultrasound
#9
Kevin J Haworth, Bryan H Goldstein, Karla P Mercado-Shekhar, Rohan Srivastava, P Arunkumar, Haili Su, Ellena M Privitera, Christy K Holland, Andrew N Redington
Modification of dissolved gas content by acoustic droplet vaporization (ADV) has been proposed for several therapeutic applications. Reducing dissolved oxygen (DO) during reperfusion of ischemic tissue during coronary interventions could inhibit reactive oxygen species production and rescue myocardium. The objective of this study was to determine whether intravascular ultrasound (IVUS) can trigger ADV and reduce DO. Perfluoropentane emulsions were created using high-speed shaking and microfluidic manufacturing...
September 2017: IEEE International Ultrasonics Symposium: [proceedings]
https://www.readbyqxmd.com/read/29909121/modeling-ultrasound-propagation-through-material-of-increasing-geometrical-complexity
#10
Maryam Odabaee, Mostafa Odabaee, Matthew Pelekanos, Gerhard Leinenga, Jürgen Götz
Ultrasound is increasingly being recognized as a neuromodulatory and therapeutic tool, inducing a broad range of bio-effects in the tissue of experimental animals and humans. To achieve these effects in a predictable manner in the human brain, the thick cancellous skull presents a problem, causing attenuation. In order to overcome this challenge, as a first step, the acoustic properties of a set of simple bone-modeling resin samples that displayed an increasing geometrical complexity (increasing step sizes) were analyzed...
June 1, 2018: Ultrasonics
https://www.readbyqxmd.com/read/29908129/the-role-of-microrna-181a-in-myocardial-fibrosis-following-myocardial-infarction-in-a-rat-model
#11
Peng Chen, Jialin Pan, Xinming Zhang, Zhewei Shi, Xiangjun Yang
BACKGROUND The role of miR-181a in the development of cardiac disease and in particular, myocardial fibrosis following myocardial infarction (MI) remains unknown. The aim of this study was to explore the role of miR-181a in myocardial fibrosis in a rat model of MI and the expression of TGF-β receptor III (TβRIII). MATERIAL AND METHODS Forty adult male Wistar rats were randomly divided into an MI model group (n=30) and a control group with (n=10). The rat MI model involved ligating the left anterior descending (LAD) coronary artery in the model group; the control group was treated with a sham operation...
June 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29906737/achilles-tendon-loading-during-weight-bearing-exercises
#12
Naghmeh Gheidi, Thomas W Kernozek, John D Willson, Andrew Revak, Keith Diers
OBJECTIVE: Compare the estimated Achilles tendon (AT) loading using a musculoskeletal model during commonly performed weight bearing therapeutic exercises. DESIGN: Controlled laboratory study. SETTING: University biomechanics laboratory. PARTICIPANTS: Eighteen healthy males (Age:22.1 ± 1.8 years, height:177.7 ± 8.4 cm, weight = 74.29 ± 11.3 kg). MAIN OUTCOME MEASURE(S): AT loading was estimated during eleven exercises: tandem, Romberg, and unilateral standing, unilateral and bilateral heel raising, unilateral and bilateral jump landing, squat, lunge, walking, and running...
May 10, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29906277/can-ultrasound-measures-of-intrinsic-foot-muscles-and-plantar-soft-tissues-predict-future-diabetes-related-foot-disease-a-systematic-review
#13
Troy Morrison, Sara Jones, Ryan S Causby, Kerry Thoirs
INTRODUCTION: Diabetes mellitus (DM) is associated with hyperglycaemia and advanced glycosylation end-products. In the foot, the consequences of chronic or uncontrolled diabetes are micro and macrovascular disease, neuropathy, reduced joint mobility and structural and soft tissue changes that increase the risk of ulcer development and amputation. Diabetes foot assessment currently includes a comprehensive history, neurological and vascular assessments and examination focussed on dermatological and musculoskeletal abnormalities...
2018: PloS One
https://www.readbyqxmd.com/read/29905630/ultrasound-guided-percutaneous-peripheral-nerve-stimulation-neuromodulation-of-the-sciatic-nerve-for-postoperative-analgesia-following-ambulatory-foot-surgery-a-proof-of-concept-study
#14
Brian M Ilfeld, Rodney A Gabriel, Engy T Said, Amanda M Monahan, Jacklynn F Sztain, Wendy B Abramson, Bahareh Khatibi, John J Finneran, Pia T Jaeger, Alexandra K Schwartz, Sonya S Ahmed
BACKGROUND AND OBJECTIVES: Percutaneous peripheral nerve stimulation (PNS) is an analgesic modality involving the insertion of a lead through an introducing needle followed by the delivery of electric current. This modality has been reported to treat chronic pain as well as postoperative pain the day following knee surgery. However, it remains unknown if this analgesic technique may be used in ambulatory subjects following foot procedures beginning within the recovery room immediately following surgery, and with only short series of patients reported to date, the only available data are derived from strictly observational studies...
June 13, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29904636/is-accurate-n-staging-for-gastric-cancer-possible
#15
Chrysovalantis Vergadis, Dimitrios Schizas
Node stage (N stage) is of paramount importance for gastric cancer staging. Radiologically node status implies detection and characterization of suspect malignant lymph nodes. Clinically it might determine survival and alter therapeutic plans. A number of modalities, including computerized tomography, MRI, PET and endoscopic ultrasound are currently available. Using a multimodality strategy, accuracy ranges between 50-90% across various studies. Specificity and sensitivity varies with respect to method, number of positive lymph nodes, their location and other characteristics...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29903054/ultrasound-triggered-drug-delivery-for-breast-tumor-therapy-through-irgd-targeted-paclitaxel-loaded-liposome-microbubble-complexes
#16
Jing Zhang, Song Wang, Zhiting Deng, Li Li, Guanghong Tan, Xin Liu, Hairong Zheng, Fei Yan
Liposome-microbubble complexes (LMC) have become a promising therapeutic carrier for ultrasound-triggered local drug release. However, it is still desirable for the released drugs to be delivered to tumors as effectively as possible. Here, we fabricated iRGD-targeted paclitaxel-loaded liposome-microbubble complexes (iRGD-PTX-LMC) and investigated the feasibility of enhancing the local drug delivery to breast tumors by using these complexes along with ultrasound irradiation. Our results showed that iRGD-modified PTX-loaded liposomes (iRGD-PTX-PL) were successfully conjugated to the surface of microbubbles (MBs) through biotin-avidin linkage...
August 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29901986/ultrasound-triggered-conversion-of-porphyrin-camptothecin-fluoroxyuridine-triad-microbubbles-into-nanoparticles-overcomes-multidrug-resistance-in-colorectal-cancer
#17
Min Chen, Xiaolong Liang, Chuang Gao, Ranran Zhao, Nisi Zhang, Shumin Wang, Wen Chen, Bo Zhao, Jinrui Wang, Zhifei Dai
Multidrug resistance remains a major obstacle to efficient chemotherapy of colorectal cancer. Herein, an efficient drug delivery and combination therapeutic strategy is proposed based on porphyrin/camptothecin-fluxoridine triad microbubbles (PCF-MBs), which show remarkably high drug loading content, highly stable co-delivery drug combinations and no premature release. The triad PCF-MBs can act not only as a contrast agent for ultrasound/fluorescence bi-modal imaging but also a multi-modal therapeutic agent for synergetic combined chemo-photodynamic therapy...
June 14, 2018: ACS Nano
https://www.readbyqxmd.com/read/29900064/induction-of-enhanced-immunogenic-cell-death-through-ultrasound-controlled-release-of-doxorubicin-by-liposome-microbubble-complexes
#18
Feng-Ying Huang, Jing Lei, Yan Sun, Fei Yan, Bin Chen, Liming Zhang, Zhuoxuan Lu, Rong Cao, Ying-Ying Lin, Cai-Chun Wang, Guang-Hong Tan
Immunogenic cell death (ICD) is a specific kind of cell death that stimulates the immune system to combat cancer cells. Ultrasound (US)-controlled targeted release of drugs by liposome-microbubble complexes is a promising approach due to its non-invasive nature and visibility through ultrasound imaging. However, it is not known whether this approach can enhance ICD induced by drugs, such as doxorubicin. Herein, we prepared a doxorubicin-liposome-microbubble complex (MbDox), and the resultant MbDox was then characterized and tested for US-controlled release of Dox (MbDox+US treatment) to enhance the induction of ICD in LL/2 and CT26 cancer cells and in syngeneic murine models...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29899537/preliminary-investigation-of-focused-ultrasound-facilitated-drug-delivery-for-the-treatment-of-leptomeningeal-metastases
#19
Meaghan A O'Reilly, Tricia Chinnery, My-Linh Yee, Sheng-Kai Wu, Kullervo Hynynen, Robert S Kerbel, Gregory J Czarnota, Kathleen I Pritchard, Arjun Sahgal
Leptomeningeal metastases (LM) are a serious complication of cancer in the central nervous system (CNS) and are diagnosed in approximately 5% of patients with solid tumors. Effective treatment using systemically administered therapeutics is hindered by the barriers of the CNS. Ultrasound can mediate delivery of drugs through these barriers. The goal of this study was to test the feasibility of using ultrasound-mediated drug delivery to improve the treatment of LM. LM was induced in the spinal cord of athymic rats by injecting HER2-expressing breast cancer cells into the subarachnoid space of the thoracic spine...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29897053/listening-in-on-the-microbubble-crowd-advanced-acoustic-monitoring-for-improved-control-of-blood-brain-barrier-opening-with-focused-ultrasound
#20
EDITORIAL
Catherine M Gorick, Natasha D Sheybani, Colleen T Curley, Richard J Price
Non-invasive drug and gene delivery to the brain to treat central nervous system pathologies has long been inhibited by the blood-brain barrier. The activation of microbubbles with focused ultrasound has emerged as a promising non-invasive approach to circumvent this obstacle, by transiently disrupting the blood-brain barrier and permitting passage of systemically administered therapeutics into the tissue. Clinical trials are underway to evaluate the safety of this technique; however, concerns remain regarding the potential for the treatment to induce sterile inflammation or petechiae...
2018: Theranostics
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