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https://www.readbyqxmd.com/read/29142305/assay-interference-and-off-target-liabilities-of-reported-histone-acetyltransferase-inhibitors
#1
Jayme L Dahlin, Kathryn M Nelson, Jessica M Strasser, Dalia Barsyte-Lovejoy, Magdalena M Szewczyk, Shawna Organ, Matthew Cuellar, Gurpreet Singh, Jonathan H Shrimp, Nghi Nguyen, Jordan L Meier, Cheryl H Arrowsmith, Peter J Brown, Jonathan B Baell, Michael A Walters
Many compounds with potentially reactive chemical motifs and poor physicochemical properties are published as selective modulators of biomolecules without sufficient validation and then propagated in the scientific literature as useful chemical probes. Several histone acetyltransferase (HAT) inhibitors with these liabilities are now routinely used to probe epigenetic pathways. We profile the most commonly used HAT inhibitors and confirm that the majority of them are nonselective interference compounds. Most (15 out of 23, 65%) of the inhibitors are flagged by ALARM NMR, an industry-developed counter-screen for promiscuous compounds...
November 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29138046/novel-cremochylomicrons-for-improved-oral-bioavailability-of-the-antineoplastic-phytomedicine-berberine-chloride-optimization-and-pharmacokinetics
#2
Manal A Elsheikh, Yosra S R Elnaggar, Dalia A Hamdy, Ossama Y Abdallah
Berberine chloride (BER) is an antineoplastic phytomedicine that combat non-Hodgkin lymphoma. BER suffers from low oral bioavailability due to P-glycoprotein efflux and first-pass metabolism. Lymphatic drug targeting recently gained a profound attention due to circumventing hepatic first-pass metabolism and targeting lymph diseases. Therefore, novel BER-loaded cremochylomicrons were elaborated to mitigate BER drawbacks and enhance its lymphatic targeting and bioavailability. Optimized cremochylomicron was prepared with 2...
November 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29137531/-i-honestly-would-not-have-known-what-to-do-an-exploratory-study-of-perspectives-on-client-suicide-among-vocational-rehabilitation-support-staff
#3
Emily M Lund, Jared C Schultz, Katie B Thomas, Michael R Nadorff, Christina M Sias, Dalia Chowdhury, Nicole R DeTore, Kate Galbraith
Despite the high prevalence of suicide both overall and among people with disabilities in particular, little research has explored suicide in the context of the vocational rehabilitation (VR) system or in counseling support staff in general. We analyzed the responses of 14 VR support staff who responded to an open-ended qualitative prompt regarding their experiences with suicide training and competency. Key themes included a perceived lack of and desire for more training regarding suicide, seeking and receiving suicide training outside of VR, and a perceived lack of resources for working with suicidal clients...
January 1, 2017: Omega
https://www.readbyqxmd.com/read/29130475/immunological-interaction-between-giardia-cyst-extract-and-experimental-toxoplasmosis
#4
Dalia S Ashour, Abeer E Saad, Lamees M Dawood, Yomna Zamzam
Toxoplasmosis is mostly associated with other intestinal parasitic infections especially Giardia due to shared mode of peroral infection. Toxoplasma and Giardia induce a strong T-helper 1- immune response. Our aim is to induce a protective immune response that results in significant impact on intestinal and extra-intestinal phases of Toxoplasma infection. This study was conducted in experimental animals and assessment of Giardia cyst extract effect on Toxoplasma infection was investigated by histopathological examination of small intestine and brain, Toxoplasma cyst count and iNOS staining of the brain, measurement of IFN-γ and TGF-β in intestinal tissues...
November 12, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/29125006/unilateral-hippocampal-wasting-after-combined-modality-therapy-for-glioblastoma
#5
Tyler M Seibert, Yoseph Dalia, Roshan Karunamuni, David Piccioni, Carrie R McDonald, Nikdokht Farid, Jona A Hattangadi-Gluth
No abstract text is available yet for this article.
November 10, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29124884/utility-of-cremophor-rh-40-as-a-micellar-improvement-for-spectrofluorimetric-estimation-of-sorafenib-in-pure-form-commercial-preparation-and-human-plasma
#6
Dalia W Zidan, Manal S Elmasry, Wafaa S Hassan, Abdalla A Shalaby
An easy, quick, simple and accurate spectrofluorimetric method was recognized and validated for evaluation of sorafenib (SOR) in pure form and biologically in plasma. Cremophor RH 40 (Cr RH 40) used for enhancing the fluorescence activity of SOR in phosphate buffer (pH 7). Cr RH 40 improved the native fluorescence of SOR remarkably in water. The fluorescence spectrum of SOR was observed at 405 nm after excitation at 265 nm. The linearity appeared to be in the range of 5 to 600 ng ml(-1) for pure and from 9 to 500 ng ml(-1) for plasma using the protein precipitation (ppt) method while from 10 to 500 ng ml(-1) for plasma using liquid-liquid extraction method...
November 10, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29123631/comparison-between-311-312-nm-narrow-band-ultraviolet-b-phototherapy-and-308-nm-monochromatic-excimer-light-phototherapy-in-treatment-of-vitiligo-a-histopathological-study
#7
Manal Mohamed Salah Eldin, Nevein Ahmed Sami, Dalia Gamal Aly, Noha Sami Hanafy
Introduction: Recently, the monochromatic excimer light (MEL) of 308 nm wavelength has shown some advantages in comparison to narrow band ultraviolet B (NB-UVB) for the treatment of vitiligo. To histopathologically compare the early effects of NB-UVB and 308-nm MEL phototherapy on vitiliginous patches using H&E and HMB-45. Methods: Thirty subjects with non-segmental vitiligo lesions were treated twice a week for 6 weeks with 308-nm MEL, while NB-UVB was used to treat lesions contra laterally. Skin biopsies were taken from lesional areas before and after 6 weeks of treatment by either modality...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29122864/complete-genome-sequences-of-mycobacteriophages-clautastrophe-kingsolomon-krypton555-and-nicholas
#8
Hui-Min Chung, Tom D'Elia, Joseph F Ross, Samuel M Alvarado, Molly-Catherine Brantley, Lydia P Bricker, Courtney R Butler, Carson Crist, Julia M Dane, Brett W Farran, Sierra Hobbs, Michelle Lapak, Conner Lovell, Nicholas Ludergnani, Allison McMullen, Sohail A Mirza, Noah Thrift, Donald P Vaughan, Grace Worley, Amara Ejikemeuwa, May Zaw, Claude F Albritton, Sarah C Bertrand, Shanzay S Chaudhry, Vzair A Cheema, Camilla Do, Michael L Do, Huyen M Duong, Dalia H El-Desoky, Kelsey M Green, Rhea N Lee, Lauren A Thornton, James M Vu, Mah Noor Zahra, Steven G Cresawn, Ty H Stoner, Rebecca A Garlena, Deborah Jacobs-Sera, Welkin H Pope, Daniel A Russell, Graham F Hatfull
We report here the complete genome sequences of four subcluster L3 mycobacteriophages newly isolated from soil samples, using Mycobacterium smegmatis mc(2)155 as the host. Comparative genomic analyses with four previously described subcluster L3 phages reveal strong nucleotide similarity and gene conservation, with several large insertions/deletions near their right genome ends.
November 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29117218/compatible-bacterial-mixture-tolerant-to-desiccation-improves-maize-plant-growth
#9
Dalia Molina-Romero, Antonino Baez, Verónica Quintero-Hernández, Miguel Castañeda-Lucio, Luis Ernesto Fuentes-Ramírez, María Del Rocío Bustillos-Cristales, Osvaldo Rodríguez-Andrade, Yolanda Elizabeth Morales-García, Antonio Munive, Jesús Muñoz-Rojas
Plant growth-promoting rhizobacteria (PGPR) increase plant growth and crop productivity. The inoculation of plants with a bacterial mixture (consortium) apparently provides greater benefits to plant growth than inoculation with a single bacterial strain. In the present work, a bacterial consortium was formulated containing four compatible and desiccation-tolerant strains with potential as PGPR. The formulation had one moderately (Pseudomonas putida KT2440) and three highly desiccation-tolerant (Sphingomonas sp...
2017: PloS One
https://www.readbyqxmd.com/read/29110792/anesthetic-management-of-the-patient-undergoing-heart-transplantation
#10
REVIEW
Liem Nguyen, Dalia A Banks
Cardiac transplantation is the treatment of choice for patients with end-stage heart failure. Over the years, significant advances in patient selection, donor optimization and selection, and optimization of immunosuppression strategies have markedly improved outcomes. In this review, we highlight patient selection, donor management and procurement, heart transplantation procedure, and intraoperative and postoperative management of heart transplants.
June 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/29107545/infectious-complications-of-ventricular-assist-device-use-in-children-in-the-united-states-data-from-the-pediatric-interagency-registry-for-mechanical-circulatory-support-pedimacs
#11
Scott R Auerbach, Marc E Richmond, Kurt R Schumacher, Dalia Lopez-Colon, Max B Mitchell, Mark W Turrentine, Ryan S Cantor, Robert A Niebler, Pirooz Eghtesady
BACKGROUND: Infections are frequent in pediatric ventricular assist device (VAD) patients. In this study we aimed to describe infections in durable VAD patients reported to Pedimacs. METHODS: Durable VAD data from the Pedimacs registry (September 19, 2012 to December 31, 2015) were analyzed. Infections were described with standard descriptive statistics, Kaplan-Meier analysis and competing outcomes analysis. RESULTS: There were 248 implants in 222 patients, with a mean age and a median follow-up of 11 ± 6...
October 3, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29105655/pre-metastatic-cancer-exosomes-induce-immune-surveillance-by-patrolling-monocytes-at-the-metastatic-niche
#12
Michael P Plebanek, Nicholas L Angeloni, Elena Vinokour, Jia Li, Anna Henkin, Dalia Martinez-Marin, Stephanie Filleur, Reshma Bhowmick, Jack Henkin, Stephen D Miller, Igal Ifergan, Yesung Lee, Iman Osman, C Shad Thaxton, Olga V Volpert
Metastatic cancers produce exosomes that condition pre-metastatic niches in remote microenvironments to favor metastasis. In contrast, here we show that exosomes from poorly metastatic melanoma cells can potently inhibit metastasis to the lung. These "non-metastatic" exosomes stimulate an innate immune response through the expansion of Ly6C(low) patrolling monocytes (PMo) in the bone marrow, which then cause cancer cell clearance at the pre-metastatic niche, via the recruitment of NK cells and TRAIL-dependent killing of melanoma cells by macrophages...
November 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29098711/child-fatalities-in-dammam-a-call-for-child-fatality-reviews-in-arab-countries
#13
Dalia Mohammed Alsaif, Osama M Almadani, Salah Ali Almoghannam, Dina Hamdi, Maram A Al-Farayedhi, Magdy A Kharosha
Identifying children's risk exposure is the first step toward mortality prevention. This retrospective study determined the causes of child fatalities in Dammam, Saudi Arabia. Death reports of children and adolescents from 1999 to 2015 (N = 157) were analyzed. Boys represented most cases (69%) and there were two age peaks (1-5 years and 16-18 years). Accidents (typically immersion) defined the main death circumstance (51%) followed by homicide (25%). Only 33% of cases underwent autopsy, and the most common cause of death was head injury (27%) followed by firearm injury...
November 3, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29094684/study-of-the-relation-between-two-common-cyclooxygenase-2-gene-polymorphisms-with-risk-of-developing-and-subtypes-of-vitiligo-in-egyptian-patients
#14
Samar Abdallah M Salem, Dalia Gamal Aly, Khalda Sayed Amr, Mahmound Fawzy Abdel-Hamid
BACKGROUND/PURPOSE: Genetic factors play an important role in the pathogenesis of vitiligo. Cyclooxygenase 2 (COX2) gene induced by ultraviolet radiation controls the synthesis of prostaglandins, which are are found to be beneficial in treating vitiligo. COX2 gene polymorphism has been previously evaluated in Chinese population. We aimed to study the relation between two common COX2 gene polymorphisms with vitiligo and its subtypes amongEgyptian patients. PATIENTS AND METHODS: This study included 200 participants (100 vitiligo patients and 100 healthy controls)...
November 1, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29094481/cxcl-10-and-interleukin-6-are-reliable-serum-markers-for-vitiligo-activity-a-multicenter-cross-sectional-study
#15
Marwa Abdallah, Medhat El-Mofty, Tag Anbar, Hoda Rasheed, Samia Esmat, Amira Al-Tawdy, Marwa M Fawzy, Dalia Abdel-Halim, Rehab Hegazy, Heba Gawdat, Dalia Bassiouny, Mona A Ibrahim, Iman Sany, Mahy El-Bassiouny, Mohamed Khalil, Abeer Abdel-Aziz, Zeinab M El Maadawi, Wedad Z Mostafa
This cross-sectional multicenter study aimed to evaluate serum CXCL-10, as an activity marker for vitiligo and compare it with other putative serum and tissue markers. Serum CXCL-10 was compared to interferon gamma (IFN-γ), interleukin 6 (IL-6) and IL-17 using ELISA in 55 non-segmental vitiligo patients (30 active and 25 stable) and 30 healthy controls. Marginal skin biopsy was taken for immunohistochemical evaluation of CD8+T-cells and CXCL-10 +ve cells. Serum levels of CXCL-10, IL-17 and IL-6 were elevated in all vitiligo patients compared to controls (P<0...
November 1, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29094459/a-novel-spectrofluorimetric-method-for-determination-of-imatinib-in-pure-pharmaceutical-preparation-human-plasma-and-human-urine
#16
Dalia W Zidan, Wafaa S Hassan, Manal S Elmasry, Abdalla A Shalaby
The following paper represents a simple, highly sensitive, responsive validated and developed spectrofluorimetric method for estimation of imatinib (IMB) in its pure, commercial preparation, human urine and human blood plasma. The calibration curve was in the range 4-900 ng ml(-1) for pure form and urine and 8-900 ng ml(-1) for plasma in a medium contains carboxymethyl cellulose (CMC) and acetate buffer (pH 5) with excitation wavelength (λex ) 230 nm and emission wavelength (λem ) 307 nm. The limit of detection (LOD) was 0...
November 2, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29093335/novel-6-phenylnicotinohydrazide-derivatives-design-synthesis-and-biological-evaluation-as-a-novel-class-of-antitubercular-and-antimicrobial-agents
#17
Dalia Hussein Soliman, Wagdy Mohamed Eldehna, Hazem Ahmed Ghabbour, Maha Mamdouh Kabil, Marwa Mostafa Abdel-Aziz, Hatem Abdel-Kader Abdel-Aziz
In our ongoing efforts to develop potent antitubercular agents based on the 6-phenylnicotinohydrazide, herein we report the design, synthesis and biological evaluation of three sets of 6-phenylnicotinohydrazide derivatives 8a-g, 12 and 16a, b. The designed compounds were synthesized and in vitro evaluated for their antitubercular activity. In addition, their antifungal and antibacterial activities were evaluated as well. The nicotinohydrazide class displayed different levels of antimicrobial activity and possessed a distinctive pattern of selectivity against the tested microorganisms...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29091037/a-quality-improvement-project-what-first-year-nursing-students-include-in-their-nursing-care-plans-for-patients-with-acute-or-chronic-wounds
#18
Barbara Pieper, Janean Monahan, Mary Kathryn Keves-Foster, Julia Farner, Dalia Alhasanat, Maha Albdour
Nursing education research is lacking with regard to nursing care plans for patients who have a wound and use of the nursing diagnosis impaired skin integrity. The purpose of this quality improvement project was to inform teaching about nursing care planning for patients with wounds by examining what rst-year nursing students attending a fundamentals of nursing course in a Bachelor of Science in Nursing program included in a nursing process assignment when caring for an assigned patient who had an acute or chronic wound...
October 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/29084071/a-study-of-red-cell-distribution-width-in-neonatal-sepsis
#19
Dalia Monir Ellahony, Muhammad S El-Mekkawy, Marwa M Farag
OBJECTIVES: The objective of this study was to evaluate a new nontraditional value of the red cell distribution width (RDW) in predicting the clinical outcome of neonatal sepsis. METHODS: In this retrospective study, data were collected from the medical files of 500 full-term neonates with a diagnosis of early onset or late onset sepsis. Baseline RDW and other traditional biomarkers, including C-reactive protein (CRP), total leucocytic count, and platelet count were analyzed in light of the clinical data...
October 27, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29080858/tailored-first-line-and-second-line-cdk4-targeting-treatment-combinations-in-mouse-models-of-pancreatic-cancer
#20
Angela Chou, Danielle Froio, Adnan M Nagrial, Ashleigh Parkin, Kendelle J Murphy, Venessa T Chin, Dalia Wohl, Angela Steinmann, Rhys Stark, Alison Drury, Stacey N Walters, Claire Vennin, Andrew Burgess, Mark Pinese, Lorraine A Chantrill, Mark J Cowley, Timothy J Molloy, Nicola Waddell, Amber Johns, Sean M Grimmond, David K Chang, Andrew V Biankin, Owen J Sansom, Jennifer P Morton, Shane T Grey, Thomas R Cox, John Turchini, Jaswinder Samra, Stephen J Clarke, Paul Timpson, Anthony J Gill, Marina Pajic
OBJECTIVE: Extensive molecular heterogeneity of pancreatic ductal adenocarcinoma (PDA), few effective therapies and high mortality make this disease a prime model for advancing development of tailored therapies. The p16-cyclin D-cyclin-dependent kinase 4/6-retinoblastoma (RB) protein (CDK4) pathway, regulator of cell proliferation, is deregulated in PDA. Our aim was to develop a novel personalised treatment strategy for PDA based on targeting CDK4. DESIGN: Sensitivity to potent CDK4/6 inhibitor PD-0332991 (palbociclib) was correlated to protein and genomic data in 19 primary patient-derived PDA lines to identify biomarkers of response...
October 28, 2017: Gut
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