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https://www.readbyqxmd.com/read/28750474/potential-misdiagnosis-of-von-willebrand-disease-and-haemophilia-caused-by-ineffective-mixing-of-thawed-plasma
#1
E J Favaloro, S Oliver, S Mohammed, M Ahuja, E Grzechnik, S Azimulla, J McDonald, G Lima-Oliveira, G Lippi
INTRODUCTION: von Willebrand disease (VWD) reflects a loss or dysfunction in von Willebrand factor (VWF), while haemophilia represents a loss or dysfunction of clotting factors such as factor VIII (FVIII) or FIX. Their diagnosis requires laboratory testing, with this potentially compromised by preanalytical events, including poor sample quality. This study assessed the effect of inadequate mixing as a potential cause of VWD and haemophilia misdiagnosis. METHODS: After completion of requested testing, 48 consecutive patient samples comprising separate aliquots from single collections were individually pooled, appropriately mixed, then frozen in separate aliquots, either at -20°C or -80°C for 2-7 days...
July 27, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28750471/modulation-of-the-activated-protein-c-pathway-in-severe-haemophilia-a-patients-the-effects-of-thrombomodulin-and-a%C3%A2-factor-v-stabilizing-fab
#2
D F Brophy, E J Martin, B M Mohammed, J C Barrett, J G Kuhn, M E Nolte, B Wiinberg, H L Holmberg, J Lund, R Salbo, E K Waters
INTRODUCTION: The thrombomodulin (TM)/activated protein C (APC) system is a key regulator of haemostasis, limiting amplification and propagation of the formed blood clot to the injury site. Dampening APC's inhibition of factor V (FV) and factor VIII (FVIII) may be a future strategy in developing next-generation therapeutic targets for haemophilia treatment. AIMS: To determine ex vivo the respective concentration-dependent effects of TM and a FV-stabilizing Fab on the APC regulatory pathway in severe FVIII-deficient blood and plasma...
July 27, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28750369/matrix-metalloproteinase-polymorphisms-in-patients-with-floppy-mitral-valve-mitral-valve-prolapse-fmv-mvp-and-fmv-mvp-syndrome
#3
Sarah M Lima, Antonios A Pitsis, Timotheos G Kelpis, Mohamed H Shahin, Taimour Y Langaee, Larisa H Cavallari, Efstratios K Theofilogiannakos, Harisios Boudoulas, Konstantinos Dean Boudoulas
BACKGROUND: It has been suggested that collagen abnormalities of the mitral valve are present in patients with floppy mitral valve (FMV)/mitral valve prolapse (MVP). Genetic factors determining collagen synthesis and degradation have not been well defined in these patients. This study was undertaken to determine whether selective polymorphisms of matrix metalloproteinase-2 (MMP2) or transforming growth factor-β (TGFβ), with known or putative effects on collagen turnover, are more frequent in FMV/MVP...
July 28, 2017: Cardiology
https://www.readbyqxmd.com/read/28750331/the-study-of-protein-biomarkers-to-understand-the-biochemical-processes-underlying-beef-color-development-in-young-bulls
#4
Mohammed Gagaoua, E M Claudia Terlouw, Brigitte Picard
This study investigates relationships between 21 biomarkers and meat color traits of Longissimus thoracis muscles of young Aberdeen Angus and Limousin bulls. The relationships found allowed to propose metabolic processes underlying meat color. The color coordinates were related with several biomarkers. The relationships were in some cases breed-dependent and the variability explained in the regression models varied between 31 and 56%. The correlations between biomarkers and color parameters were sometimes opposite between breeds...
July 18, 2017: Meat Science
https://www.readbyqxmd.com/read/28750312/synthesis-of-2-imino-and-2-hydrazono-thiazolo-4-5-d-pyrimidines-as-corticotropin-releasing-factor-crf-antagonists
#5
Mohamed Teleb, Bhimanna Kuppast, Katerina Spyridaki, George Liapakis, Hesham Fahmy
Corticotropin-releasing factor (CRF) is an important neuropeptide hormone which controls the body's overall response to stress. It plays a crucial role in regulating the behavioral, cardiovascular, immune and gastrointestinal systems. Over-activation of the CRF system has been implicated in many disorders including anxiety, depression, drug addiction, hypertension, Irritable Bowel Syndrome (IBS), peptic ulcers, inflammation and others. Thus, binding of CRF to its receptors is an attractive target to develop new medications which aim at treating ailments associated with chronic stress...
July 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28750308/an-innovative-validated-spectrofluorimetric-method-for-determination-of-lisinopril-in-presence-of-hydrochlorothiazide-application-to-content-uniformity-testing
#6
Sayed M Derayea, Khalid M Badr El-Din, Fatma F Mohammed
A new sensitive and discriminating spectrofluorimetric method has been developed and validated for determination of Lisinopril, one of the angiotensin converting enzyme inhibitors, in its pure bulk form and pharmaceutical tablets. The reaction of Lisinopril with ethylacetoacetate and formaldehyde in acidic buffered medium (pH3.8) has yielded a pale yellow product that exhibited a high fluorescence measured at 438nm after excitation at 350nm. All the experimental parameters affecting the formation and stability of the produced fluorophore were carefully investigated and optimized to give the maximum sensitivity...
July 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28750210/phosphorylated-neurofilament-h-pnf-h-as-a-potential-diagnostic-marker-for-neurological-disorders-in-horses
#7
A R Intan-Shameha, Thomas J Divers, Jennifer K Morrow, Amy Graves, Emil Olsen, Amy L Johnson, Hussni O Mohammed
The current study aimed at the investigating the potential use of phosphorylated neurofilament H (pNF-H) as a diagnostic biomarker for neurologic disorders in the horse. Paired serum and cerebrospinal fluid (CSF) samples (n=88) and serum only (n=30) were obtained from horses diagnosed with neurologic disorders and clinically healthy horses as control. The neurologic horses consisted of equine protozoal myeloencephalitis (EPM) (38 cases) and cervical vertebral malformation (CVM) (23 cases). Levels of pNF-H were determined using an ELISA...
July 18, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28750203/synthesis-%C3%AE-glucosidase-inhibitory-activity-and-in-silico-study-of-tris-indole-hybrid-scaffold-with-oxadiazole-ring-as-potential-leads-for-the-management-of-type-ii-diabetes-mellitus
#8
Muhammad Taha, Fazal Rahim, Syahrul Imran, Nor Hadiani Ismail, Hayat Ullah, Manikandan Selvaraj, Muhammad Tariq Javid, Uzma Salar, Muhammad Ali, Khalid Mohammed Khan
Discovery of α-glucosidase inhibitors has been actively pursued with the aim to develop therapeutics for the treatment of type-II diabetes mellitus and the other carbohydrate mediated disease. In continuation of our drug discovery research on potential antidiabetic agents, we synthesized novel tris-indole-oxadiazole hybrid analogs (1-21), structurally characterized by various spectroscopic techniques such as (1)H NMR, EI-MS, and (13)C NMR. Elemental analysis was found in agreement with the calculated values...
July 18, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28749963/expression-of-intra-and-extracellular-granzymes-in-patients-with-typhoid-fever
#9
Hanna K de Jong, Maria Isabel Garcia-Laorden, Arie J Hoogendijk, Christopher M Parry, Rapeephan R Maude, Arjen M Dondorp, Mohammed Abul Faiz, Tom van der Poll, Willem Joost Wiersinga
BACKGROUND: Typhoid fever, caused by the intracellular pathogen Salmonella (S.) enterica serovar Typhi, remains a major cause of morbidity and mortality worldwide. Granzymes are serine proteases promoting cytotoxic lymphocytes mediated eradication of intracellular pathogens via the induction of cell death and which can also play a role in inflammation. We aimed to characterize the expression of extracellular and intracellular granzymes in patients with typhoid fever and whether the extracellular levels of granzyme correlated with IFN-γ release...
July 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28749945/quantitative-computed-tomography-determined-regional-lung-mechanics-in-normal-nonsmokers-normal-smokers-and-metastatic-sarcoma-subjects
#10
Jiwoong Choi, Eric A Hoffman, Ching-Long Lin, Mohammed M Milhem, Jean Tessier, John D Newell
OBJECTIVES: Extra-thoracic tumors send out pilot cells that attach to the pulmonary endothelium. We hypothesized that this could alter regional lung mechanics (tissue stiffening or accumulation of fluid and inflammatory cells) through interactions with host cells. We explored this with serial inspiratory computed tomography (CT) and image matching to assess regional changes in lung expansion. MATERIALS AND METHODS: We retrospectively assessed 44 pairs of two serial CT scans on 21 sarcoma patients: 12 without lung metastases and 9 with lung metastases...
2017: PloS One
https://www.readbyqxmd.com/read/28749784/concentrations-of-leptin-adiponectin-and-other-metabolic-parameters-in-non-obese-children-with-down-syndrome
#11
Nikhil Tenneti, Devi Dayal, Sheetal Sharda, Inusha Panigrahi, Mohammed Didi, Savita Verma Attri, Naresh Sachdeva, Anil Kumar Bhalla
BACKGROUND: Recent data indicates that adults with Down syndrome (DS) are at increased risk for cardiovascular disease (CVD) that significantly contributes to their morbidity and mortality. Although identification of cardiometabolic risk factors during childhood is desirable to design preventive interventions, the data on such risk factors in children with DS is scarce. The aim of this study was to study the cardiometabolic risk factors such as insulin resistance (IR), leptin and adiponectin concentrations, lipid abnormalities and leptin resistance in non-obese children with DS...
July 27, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28749773/hemolytic-potential-of-tafenoquine-in-female-volunteers-heterozygous-for-glucose-6-phosphate-dehydrogenase-g6pd-deficiency-g6pd-mahidol-variant-versus-g6pd-normal-volunteers
#12
Ronnatrai Rueangweerayut, Germana Bancone, Emma J Harrell, Andrew P Beelen, Supornchai Kongpatanakul, Jörg J Möhrle, Vicki Rousell, Khadeeja Mohamed, Ammar Qureshi, Sushma Narayan, Nushara Yubon, Ann Miller, François H Nosten, Lucio Luzzatto, Stephan Duparc, Jörg-Peter Kleim, Justin A Green
Tafenoquine is an 8-aminoquinoline under investigation for the prevention of relapse in Plasmodium vivax malaria. This open-label, dose-escalation study assessed quantitatively the hemolytic risk with tafenoquine in female healthy volunteers heterozygous for the Mahidol(487A) glucose-6-phosphate dehydrogenase (G6PD)-deficient variant versus G6PD-normal females, and with reference to primaquine. Six G6PD-heterozygous subjects (G6PD enzyme activity 40-60% of normal) and six G6PD-normal subjects per treatment group received single-dose tafenoquine (100, 200, or 300 mg) or primaquine (15 mg × 14 days)...
July 24, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28749763/outbreak-of-sudden-death-with-acute-encephalitis-syndrome-among-children-associated-with-exposure-to-lychee-orchards-in-northern-bangladesh-2012
#13
Mohammed Saiful Islam, Ahmad Raihan Sharif, Hossain M S Sazzad, A K M Dawlat Khan, Murshid Hasan, Shirina Akter, Mahmudur Rahman, Stephen P Luby, James D Heffelfinger, Emily S Gurley
Recurrent outbreaks of acute encephalitis syndrome (AES) among children in lychee growing areas in Asia highlight the need to better understand the etiology and the context. We conducted a mixed-methods study to identify risk factors for disease, and behaviors and practices around lychee cultivation in an AES outbreak community in northern Bangladesh in 2012. The outbreak affected 14 children; 13 died. The major symptoms included unconsciousness, convulsion, excessive sweating, and frothy discharge. The median time from illness onset to unconsciousness was 2...
July 24, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28749548/c-myc-positive-relapsed-and-refractory-diffuse-large-b-cell-lymphoma-impact-of-additional-hits-and-outcomes-with-subsequent-therapy
#14
Narendranath Epperla, Kami J Maddocks, Mohammed Salhab, Julio C Chavez, Nishitha Reddy, Reem Karmali, Elvira Umyarova, Veronika Bachanova, Cristiana Costa, Martha Glenn, Oscar Calzada, Ana C Xavier, Zheng Zhou, Nasheed M Hossain, Francisco J Hernandez-Ilizaliturri, Zeina Al-Mansour, Stefan K Barta, Saurabh Chhabra, Frederick Lansigan, Amitkumar Mehta, Michael V Jaglal, Andrew Evans, Christopher R Flowers, Jonathon B Cohen, Timothy S Fenske, Mehdi Hamadani, Luciano J Costa
BACKGROUND: The impact of MYC proto-oncogene, basic helix-loop-helix (MYC) translocations (with or without additional rearrangements involving the B-cell lymphoma 2 [BCL2] or BCL6 genes) on the response to salvage therapy and survival in patients with diffuse large B-cell lymphoma (DLBCL) who experience primary treatment failure is not well defined. METHODS: This was a multicenter, retrospective study of the impact of MYC, BCL2, and BCL6 rearrangements in patients with DLBCL who failed to achieve complete remission or relapsed within 6 months after they completed upfront chemoimmunotherapy...
July 27, 2017: Cancer
https://www.readbyqxmd.com/read/28749478/molecular-autopsy-in-maternal-fetal-medicine
#15
Hanan E Shamseldin, Wesam Kurdi, Fatima Almusafri, Maha Alnemer, Alya Alkaff, Zeneb Babay, Amal Alhashem, Maha Tulbah, Nada Alsahan, Rubina Khan, Bahauddin Sallout, Elham Al Mardawi, Mohamed Zain Seidahmed, Niema Meriki, Yasser Alsaber, Alya Qari, Ola Khalifa, Wafaa Eyaid, Zuhair Rahbeeni, Ahmed Kurdi, Mais Hashem, Tarfa Alshidi, Eman Al-Obeid, Firdous Abdulwahab, Niema Ibrahim, Nour Ewida, Karen El-Akouri, Mariam Al Mulla, Tawfeg Ben-Omran, Matthias Pergande, Sebahattin Cirak, Saeed Al Tala, Ranad Shaheen, Eissa Faqeih, Fowzan S Alkuraya
PurposeThe application of genomic sequencing to investigate unexplained death during early human development, a form of lethality likely enriched for severe Mendelian disorders, has been limited.MethodsIn this study, we employed exome sequencing as a molecular autopsy tool in a cohort of 44 families with at least one death or lethal fetal malformation at any stage of in utero development. Where no DNA was available from the fetus, we performed molecular autopsy by proxy, i.e., through parental testing.ResultsPathogenic or likely pathogenic variants were identified in 22 families (50%), and variants of unknown significance were identified in further 15 families (34%)...
July 27, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28749158/a-wait-list-controlled-study-of-a-trauma-focused-cognitive-behavioral-treatment-for-intermittent-explosive-disorder-in-timor-leste
#16
Kalhari Hewage, Zachary Steel, Mohammed Mohsin, Alvin Kuowei Tay, Jose Carlos De Oliveira, Marcio Da Piedade, Natalino Tam, Derrick Silove
We tested a trauma-focused, cognitive-behavior therapy treatment (TF-CBT-anger) for intermittent explosive disorder (IED) and related dimensions of anger adapted to the local culture in postconflict Timor-Leste. The intention-to-treat sample (n = 78) comprised Timorese nationals (women = 49; men = 29), ages 18 years and older, meeting Diagnostic and Statistical Manual of Mental Disorders (4th ed.) criteria for IED, with equal numbers (n = 39 each) being randomized to the treatment group (TG) and wait-list (WL)...
July 27, 2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28749119/antitumor-exopolysaccharides-derived-from-novel-marine-bacillus-isolation-characterization-aspect-and-biological-activity
#17
Salma M Abdelnasser, Shaymaa M M Yahya, Wafaa F Mohamed, Mohsen MS Asker, Hala M Abu Shady, Manal G Mahmoud, Magdy A Gadallah
Objective: Exopolysaccharides gained attention as new source for cancer treatment as recent treatments cause side effects and multidrug resistance. Polysaccharides containing sulfur and uronic acids exhibited antioxidant activity, by restoring cell redox regulation, thus inhibiting cell proliferation and cancer formation. Following this context, our study was performed to assess the cytotoxic activity of exopolysaccharides produced by novel Egyptian marine bacterial strains on HepG2 cells. Methods: Bacteria were isolated, purified and cultured through routine microbiological techniques...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749066/donor-dependent-and-other-nondefined-factors-have-greater-influence-on-the-hepatic-phenotype-than-the-starting-cell-type-in-induced-pluripotent-stem-cell-derived-hepatocyte-like-cells
#18
James A Heslop, Richard Kia, Christopher S Pridgeon, Rowena L Sison-Young, Triantafillos Liloglou, Mohamed Elmasry, Stephen W Fenwick, John S Mills, Neil R Kitteringham, Chris E Goldring, B Kevin Park
No abstract text is available yet for this article.
August 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28748901/renal-manifestations-in-hypocomplementic-urticarial-vasculitis-syndrome-is-it-a-distinct-pathology
#19
Badriya AlHermi, Zakiya Al Mosawi, Deena Mohammed
Hypocomplementic urticarial vasculitis syndrome (HUVS) is an autoimmune disease characterized by recurrent urticaria, arthritis, and glomerulonephritis (GN). Anti-C1q antibody is the marker of HUVS together with low levels of classical pathway complements which are C2, C3, C4, and C1q. We report a case of a 6-year-old boy who presented with episodes of rashes, injected conjunctiva, abdominal pain, and arthritis, diagnosed as HUVS. He had low C3, low CH50, normal C4, and positive C1q antibody. His urinalysis showed intermittent microscopic hematuria only...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748888/childhood-idiopathic-steroid-resistant-nephrotic-syndrome-at-a-single-center-in-khartoum
#20
El-Tigani M A Ali, Hanna F K Makki, Mohamed B Abdelraheem, Salwa O Makke, Rashid A Allidir
Prevalence, clinicopathological features, and outcome of childhood idiopathic steroid-resistant nephrotic syndrome (ISRNS) vary in different countries. We report on these parameters in a single center in Khartoum. We retrospectively reviewed all the records of children with idiopathic nephrotic syndrome (INS) followed up in the pediatric renal unit, Soba Hospital, Khartoum between 2001 and 2012. ISRNS was defined as no remission within four weeks of daily prednisolone at a dose of 60 mg/m2. In 430 children with INS 130 (28%) had SRNS with a mean age of 7...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
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