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https://www.readbyqxmd.com/read/28454422/the-role-of-mrp1-in-the-multidrug-resistance-of-colorectal-cancer
#1
Dongxing Cao, Shaolan Qin, Yifei Mu, Ming Zhong
The role of multidrug resistance associated protein 1 (MRP1) in the multidrug resistance (MDR) of colorectal cancer (CRC) remains unclear. The present study aimed to investigate the effect of MRP1 in MDR CRC and its therapeutic potential for the treatment of patients with this disease. The human MDR CRC cell lines HCT-8 and Colo205 were established through stable exposure to 5-florouracil (5-FU) over a 5-month period. MRP1 was knocked-down in MDR CRC cells through the transfection of short hairpin RNA targeting MRP1 (shMRP1)...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28448852/reproducibility-of-scapular-muscle-activity-in-isokinetic-shoulder-flexion-and-extension
#2
Monique Wochatz, Sophie Rabe, Martin Wolter, Tilman Engel, Steffen Mueller, Frank Mayer
Repetitive overhead movements have been identified as a main risk factor to develop shoulder complaints with scapular muscle activity being altered. Reliable assessment of muscle activity is essential to differentiate between symptomatic and asymptomatic individuals. Therefore, the present study aimed to investigate the intra- and inter-session reliability of scapular muscle activity during maximal isokinetic shoulder flexion and extension. Eleven asymptomatic adults performed maximum effort isokinetic shoulder flexion and extension (concentric and eccentric at 60°/s) in a test-retest design...
April 13, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28446376/comparison-of-virtual-reality-exergaming-and-home-exercise-programs-in-patients-with-subacromial-impingement-syndrome-and-scapular-dyskinesis-short-term-effect
#3
Nihan Ozunlu Pekyavas, Nevin Ergun
OBJECTIVE: The aim of this study was to compare the short term effects of home exercise program and virtual reality exergaming in patients with subacromial impingement syndrome (SAIS). METHODS: A total of 30 patients with SAIS were randomized into two groups which are Home Exercise Program (EX Group) (mean age: 40.6 ± 11.7 years) and Virtual Reality Exergaming Program (WII Group) (mean age: 40.33 ± 13.2 years). Subjects were assessed at the first session, at the end of the treatment (6 weeks) and at 1 month follow-up...
April 24, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28425817/intrarater-reliability-of-assessing-strength-of-the-shoulder-and-scapular-muscles
#4
Derya Celik, Ahmet Dirican, Gul Baltaci
No abstract text is available yet for this article.
January 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28424466/the-role-of-the-brown-adipose-tissue-in-%C3%AE-3-adrenergic-receptor-activation-induced-sleep-metabolic-and-feeding-responses
#5
Éva Szentirmai, Levente Kapás
Brown adipose tissue (BAT) is regulated by the sympathetic nervous system via β3-adrenergic receptors (β3-AR). Here we tested the hypothesis that pharmacological stimulation of β3-ARs leads to increased sleep in mice and if this change is BAT dependent. In wild-type (WT) animals, administration of CL-316,243, a selective β3-AR agonist, induced significant increases in non-rapid-eye movement sleep (NREMS) lasting for 4-10 h. Simultaneously, electroencephalographic slow-wave activity (SWA) was significantly decreased and body temperature was increased with a delay of 5-6 h...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420897/in-vivo-analysis-of-three-dimensional-dynamic-scapular-dyskinesis-in-scapular-or-clavicular-fractures
#6
Eugene Kim, Jai Hyung Park, Byeong-Ryong Han, Hee Jin Park, So Yeon Lee, Tsuyoshi Murase, Kazumi Sugamoto, Sumika Ikemoto, Se-Jin Park
The three-dimensional (3D) kinematics of the scapula were analyzed in vivo in 10 patients with scapular and 10 patients with clavicular fracture. Both the injured shoulder and normal contralateral shoulder were evaluated by computed tomography in the neutral and fully elevated positions. 3D rotational and translational movements of the scapula relative to the thorax during arm elevation were analyzed. A computer simulation program was used to compare rotational elevation/depression in the coronal plane, anterior/posterior tilting in the sagittal plane and protraction/retraction in the axial plane between the normal and affected sides...
April 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28416022/specific-or-general-exercise-strategy-for-subacromial-impingement-syndrome-does-it-matter-a-systematic-literature-review-and-meta-analysis
#7
Alison R Shire, Thor A B Stæhr, Jesper B Overby, Mathias Bastholm Dahl, Julie Sandell Jacobsen, David Høyrup Christiansen
BACKGROUND: Exercise is frequently suggested as a treatment option for patients presenting with symptoms of subacromial impingement syndrome. Some would argue implementing a specific exercise strategy with special focus on correction of kinematic deficits would be superior to general exercise strategy. There is however a lack of evidence comparing such exercise strategies to determine which is the most effective in the treatment of subacromial impingement syndrome. The aim of this review is to evaluate whether implementing specific exercise strategies involving resistive exercises are more effective than a general exercise strategy for the treatment of patients with subacromial impingement syndrome...
April 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28408254/midterm-outcomes-of-bone-grafting-in-glenoid-defects-treated-with-reverse-shoulder-arthroplasty
#8
Yaiza Lopiz, Carlos García-Fernández, Alvaro Arriaza, Belen Rizo, Hector Marcelo, Fernando Marco
BACKGROUND: Large glenoid defects are a difficult reconstructive problem for shoulder surgeons. The purpose of this study was to determine the complications, rate of healing, and functional results of glenoid bone grafting in primary or revision surgery with reverse shoulder arthroplasty. METHODS: We retrospectively reviewed 23 patients with glenoid bone loss who underwent primary or revision surgery using a glenoid bone graft with a minimum follow-up of 2 years...
April 10, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28406877/scapulothoracic-dissociation-evaluation-and-management
#9
Andrew M Choo, Patrick C Schottel, Andrew R Burgess
Scapulothoracic dissociation is a rare, potentially limb- and life-threatening injury of the shoulder girdle. The injury is characterized by lateral displacement of the scapula resulting from traumatic disruption of the scapulothoracic articulation. The typical physical examination findings consist of substantial swelling of the shoulder girdle, along with weakness, numbness, and pulselessness in the ipsilateral upper extremity. Radiographic evaluation includes measurement of the scapular index on a nonrotated chest radiograph and assessment for either a distracted clavicle fracture or a disrupted acromioclavicular or sternoclavicular joint...
May 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28405603/mtor-inhibition-by-everolimus-does-not-impair-closure-of-punch-biopsy-wounds-in-renal-transplant-patients
#10
Shelley B Dutt, Josephine Gonzales, Megan Boyett, Anne Costanzo, Peggy P Han, Steven Steinberg, Dianne B McKay, Julie M Jameson
BACKGROUND: Mammalian target of rapamycin (mTOR) inhibitors are approved to prevent allograft rejection and control malignancy. Unfortunately, they are associated with adverse effects, such as wound healing complications that detract from more extensive use. There is a lack of prospective wound healing studies to monitor patients treated with mTOR inhibitors, such as everolimus or sirolimus, especially in nondiabetics. METHODS: Patients receiving everolimus with standard immunosuppressant therapy or standard immunosuppressant therapy without everolimus were administered 3-mm skin biopsy punch wounds in the left scapular region...
April 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28405223/electromyographic-activity-of-the-shoulder-muscles-during-rehabilitation-exercises-in-subjects-with-and-without-subacromial-pain-syndrome-a-systematic-review
#11
REVIEW
Rita Kinsella, Tania Pizzari
BACKGROUND: Subacromial pain syndrome (SPS) is a common cause of shoulder pain and muscle activity deficits are postulated to contribute to the development and progression of the disorder. The purpose of this systematic review was to definitively determine whether evidence exists of differences in electromyography (EMG) characteristics between subjects with and without SPS. METHODS: Six key databases were searched: MEDLINE, EMBASE, CINAHL, SPORTdiscus, PEDro and The Cochrane Library (inception to May 2016)...
April 2017: Shoulder & Elbow
https://www.readbyqxmd.com/read/28396962/elevated-%C3%AE-hcg-associated-with-aggressive-osteoblastoma
#12
Carol D Morris, Meera R Hameed, Narasimhan P Agaram, Sinchun Hwang
We present a unique case of an aggressive scapular osteoblastoma that produced β-hCG as a paraneoplastic manifestation in a 20-year-old woman. Serum β-hCG was found to be elevated during presurgical workup and consequently delayed surgical resection of the increasingly painful tumor because of suspected pregnancy. The paraneoplastic production of β-hCG was later proven by positive immunohistochemical stain of β-hCG in a curettage specimen and normalization of β-hCG levels after surgical resection of the aggressive osteoblastoma...
April 10, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28395752/efficacy-of-a-new-spot-on-formulation-of-selamectin-plus-sarolaner-for-cats-against-adult-ctenocephalides-felis-flea-egg-production-and-adult-flea-emergence
#13
Adriano F Vatta, William R Everett, Susan J Holzmer, Judith A Cherni, Vickie L King, Douglas Rugg, Thomas Geurden
A new spot-on formulation of selamectin plus sarolaner was evaluated against fleas for adulticidal efficacy, and for the effect on egg production and hatching when applied to flea-infested cats. Ten male and ten female adult domestic shorthair cats were randomly assigned to one of two treatment groups based on pre-treatment flea counts. Cats received topical treatment on Day 0 in a single spot to the dorsal scapular area with either a placebo formulation or with the combination formulation at the minimal dose of 6...
April 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28392950/diffuse-subcutaneous-emphysema-and-pneumomediastinum-secondary-to-a-minor-blunt-chest-trauma
#14
Maximilian Andreas Storz, Eric P Heymann, Aristomenis K Exadaktylos
Full medical evaluation is paramount for all trauma patients. Minor traumas are often overlooked, as they are thought to bear low injury potential. In this case report, we describe the case of a 48-year-old man presenting to our Emergency Department with mild to moderate right-sided shoulder and scapular pain following a fall from his own height ten days previously. Clinical and paraclinical investigations (CT) revealed diffuse right shoulder pain, with crepitations on palpation of the neck, right shoulder, and right lateral chest wall...
2017: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/28382716/identical-presentation-of-scapular-osteolysis-in-two-patients-with-thoracic-kaposiform-hemangioendothelioma
#15
Verónica Alonso Arroyo, Juan Carlos Lopez-Gutierrez, Rox Martinez, Israel Fernandez-Pineda
Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor that does not metastasize. We report two unique cases of KHE involving the right hemithorax and the upper ipsilateral extremity. Kasabach-Merrit phenomenon and osteolytic lesions in the scapula were observed in both cases.
April 6, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28376941/systematic-evaluation-of-skeletal-fractures-caused-by-induction-of-electroconvulsive-seizures-in-rat-state-a-need-for-attention-and-refinement-of-the-procedure
#16
Maria Ekemohn, Marie Kjær Nielsen, Matilda Grahm, Anders Tingström, Birgitte Kousholt, Gregers Wegener, Cecilie Bay-Richter
OBJECTIVE: Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects of ECT. As the treatment itself serves as an instant anaesthetic and anaesthetic agents may affect memory functions and behaviour, ECS is traditionally administered without muscle relaxation and anaesthesia. A major problem of unmodified ECS, which has only been addressed peripherally in the literature, is that some animals sustain spinal fractures and subsequent hind leg paralysis (paraplegia)...
April 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28372968/interest-in-the-glenoid-hull-method-for-analyzing-humeral-subluxation-in-primary-glenohumeral-osteoarthritis
#17
Soufyane Bouacida, Marc-Olivier Gauci, Bertrand Coulet, Cyril Lazerges, Catherine Cyteval, Pascal Boileau, Michel Chammas
BACKGROUND: Posterior humeral subluxation is the main cause of failure of total shoulder arthroplasty. We aimed to compare humeral head subluxation in various reference planes and to search for a correlation with retroversion, inclination, and glenoid wear. MATERIALS AND METHODS: We included 109 computed tomography scans of primary glenohumeral osteoarthritis and 97 of shoulder problems unrelated to shoulder osteoarthritis (controls); all computed tomography scans were reconstructed in the anatomic scapular plane and the glenoid hull plane that we defined...
March 31, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28372964/glenoid-bone-grafting-in-primary-reverse-total-shoulder-arthroplasty
#18
Lukas Ernstbrunner, Jean-David Werthel, Eric Wagner, Taku Hatta, John W Sperling, Robert H Cofield
BACKGROUND: Severe glenoid bone loss remains a challenge in patients requiring shoulder arthroplasty and may necessitate glenoid bone grafting. The purpose of this study was to determine results, complications, and rates of failure of glenoid bone grafting in primary reverse shoulder arthroplasty. METHODS: Forty-one shoulders that underwent primary reverse arthroplasty between 2006 and 2013 with a minimum follow-up of 2 years (mean, 2.8 years; range, 2-6 years) were reviewed...
March 31, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28370473/-half-folded-pedicled-scapular-bone-flap-for-nonunion-after-humeral-neck-fracture-a-case-report
#19
Gen Matsumae, Makoto Motomiya, Naoya Watanabe, Norimasa Iwasaki
Treatment of a nonunion of the proximal humerus remains a challenge because of the small proximal fragment and poor central cancellous bone stock of the humeral head. In this report, we describe our experience using a "half-folded" pedicled scapular bone flap with an anatomical locking plate to treat an atrophic nonunion of the proximal humerus in a 64-year-old right-handed woman. The patient had fallen and experienced a common humeral neck fracture 2.5 years previously. During the operation, we elevated the pedicled scapular bone flap, which measured 8...
March 28, 2017: Microsurgery
https://www.readbyqxmd.com/read/28370186/neoplastic-pleural-effusion-and-intrathoracic-metastasis-of-a-scapular-osteosarcoma-in-a-dog-a-multidisciplinary-integrated-diagnostic-approach
#20
Luis Mesquita, Jeremy Mortier, Lorenzo Ressel, Riccardo Finotello, Paolo Silvestrini, Martina Piviani
A 10-year-old, female spayed mixed-breed or cross-bred dog was referred to the Small Animal Teaching Hospital of the University of Liverpool due to tachypnea, dyspnea, and pleural effusion not responding to diuretics and antibiotics. The chest was drained and cytology of the pleural fluid was consistent with a modified transudate with presence of atypical cells initially attributed to mesothelial hyperplasia and dysplasia. Computed tomography detected, in addition to the bilateral pleural effusion, diffuse pleural thickening, multiple pleural and pulmonary nodules, and a mineralized and lytic mass in the left scapula...
March 29, 2017: Veterinary Clinical Pathology
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